Publications
| Title | Abstract | Year Filter | PMID(sorted ascending) Filter |
|---|
| shaken or stirred?: comparison of methods for dispersion of mycoplasma pneumoniae aggregates for persistence in vivo. | mycoplasma pneumoniae (mpn), one of the smallest self-replicating prokaryotes, is known to readily adhere to host cells and to form aggregates in suspension. having only one cell membrane and no cell wall, mycoplasmas present questions as to optimal aggregate disruption method while minimizing cell death in vitro. we compared conventional vortex mixing with other methods for disruption of bacterial aggregates and for its effect on cell viability. | 2017 | 27865739 |
| valuable hematological indicators for the diagnosis and severity assessment of chinese children with community-acquired pneumonia: prealbumin. | chest x-ray is a "golden standard" for the diagnosis and severity assessment of community-acquired pneumonia (cap). however, it cannot be used as routine examination of cap in children. the present study aims to investigate the roles of prealbumin (pa) in cap in children and further determine the usefulness of pa in diagnosis and severity assessment of cap in children.this was a retrospective analysis of 174 cases of hospitalized children with cap. the following indicators were recorded: vital s ... | 2016 | 27893691 |
| stevens-johnson syndrome in childhood. | stevens-johnson syndrome and toxic epidermal necrolysis are two serious immune diseases within the context of bullous mucocutaneous syndrome. these have varying degrees of involvement of the skin and usually at least two mucous membranes. | 2016 | 27899204 |
| a case of urticarial vasculitis in a female patient with lupus: mycoplasma pneumoniae infection or lupus reactivation? | a 17-year-old female patient affected by systemic lupus erythematosus (sle) (who had been taking 300 mg/die of hydroxychloroquine for 3 years), graves' disease (treated with 10 mg/die of tapazole), and celiac disease came to our attention for urticarial vasculitis. she had been taking prednisone (25 mg/die) for 3 days, and her blood tests showed high levels of mycoplasma pneumoniae igm and igg antibodies. the association between urticaria and m. pneumoniae infections can be present in up to 7% o ... | 2016 | 27921149 |
| annular leukocytoclastic vasculitis and infection by mycoplasma pneumoniae. | 2016 | 27923463 | |
| development of a multiplex taqman real-time pcr assay for typing of mycoplasma pneumoniae based on type-specific indels identified through whole genome sequencing. | we developed a multiplex real-time pcr assay for simultaneously detecting m. pneumoniae and typing into historically-defined p1 types. typing was achieved based on the presence of short type-specific indels identified through whole genome sequencing. this assay was 100% specific compared to existing methods and may be useful during epidemiologic investigations. | 2017 | 27923522 |
| relationships between th1/th2 cytokine profiles and chest radiographic manifestations in childhood mycoplasma pneumoniae pneumonia. | mycoplasma pneumoniae pneumonia (mpp) is one of the most common childhood community-acquired pneumonias, and the chest radiograph usually shows bronchial pneumonia, segmental/lobar pneumonia, or segmental/lobar pneumonia with pleural effusion. the imbalance of th1/th2 function after mycoplasma pneumoniae infection is an important immunological mechanism of mpp. in this study, we aimed to evaluate the correlations between th1/th2 cytokine profiles and chest radiographic manifestations in mpp chil ... | 2016 | 27956836 |
| role of atypical pathogens in the etiology of community-acquired pneumonia. | atypical pneumonia has been described for over 100 years, but some of the pathogens attributed to it have been identified only in the past decades. the most common pathogens are chlamydia pneumoniae, mycoplasma pneumoniae, and legionella pneumophila. the epidemiology and pathophysiology of these three pathogens have been studied since their discovery, and are reviewed herein to provide better insight when evaluating these patients, which hopefully translates into improved care. the incidence of ... | 2016 | 27960206 |
| community-acquired pneumonia in the asia-pacific region. | community-acquired pneumonia (cap) is an important cause of mortality and morbidity worldwide. aging population, dense urbanization, and poor access to health care make the asia-pacific region vulnerable to cap. the high incidence of cap poses a significant health and economic burden in this region. common etiologic agents in other global regions including streptococcus pneumoniae, mycoplasma pneumoniae, haemophilus influenzae, chlamydophila pneumoniae, staphylococcus aureus, and respiratory vir ... | 2016 | 27960208 |
| [association of t lymphocyte subsets and allergens with mycoplasma pneumoniae infection complicated by wheezing in infants and young children]. | to investigate the percentage of t lymphocyte subsets and allergen screening results in infants and young children with mycoplasma pneumoniae (mp) infection complicated by wheezing. | 2016 | 27974117 |
| [risk factors for recurrent wheezing in infants and young children suffering from dust mite allergy after their first wheezing]. | to investigate the risk factors for recurrent wheezing in infants and young children suffering from dust mite allergy after their first wheezing. | 2016 | 27974118 |
| an itraq-based quantitative proteomics study of refractory mycoplasma pneumoniae pneumonia patients. | mycoplasma pneumoniae(mp) is a leading cause of community-acquired pneumonia in children and young adults. although mp pneumonia is usually benign and self-limited, in some cases it can develop into a life-threating refractory mp pneumonia(rmpp). however, the pathogenesis of rmpp is poorly understood. the identification and characterization of proteins related to rmpp could provide "proof of principle" to facilitate appropriate diagnostic and therapeutic strategies for mp patients. in this study ... | 2016 | 28003598 |
| the clinical characteristics of corticosteroid-resistant refractory mycoplasma pneumoniae pneumonia in children. | to analyze the clinical characteristics of corticosteroid-resistant refractory mycoplasma pneumoniae pneumonia (rmpp) and explore the related factors that predict corticosteroid-resistant rmpp. retrospective analysis of 183 children with rmpp in our hospital admitted between january 1, 2012, and december 31, 2014 was performed. of the 183 rmpp cases, 36 (19.7%) were corticosteroid-resistant rmpp cases. corticosteroid-resistant rmpp cases had a longer duration of fever and hospitalization compare ... | 2016 | 28008989 |
| screening and identification of apoc1 as a novel potential biomarker for differentiate of mycoplasma pneumoniae in children. | background: although mycoplasma pneumoniae (mp) is a common cause of community-acquired pneumonia (cap) in children, the currently used diagnostic methods are not optimal. proteomics is increasingly being used to study the biomarkers of infectious diseases. methods: label-free quantitative proteomics and liquid chromatography-mass/mass spectrometry were used to analyze the fold change of protein expression in plasma of children with mp pneumonia (mpp), infectious disease control (idc), and healt ... | 2016 | 28018301 |
| characterization of the neurological diseases associated with mycoplasma pneumoniae infection and anti-glycolipid antibodies. | mycoplasma pneumoniae infection often causes various neurological complications of both the central nervous system (cns) and the peripheral nervous system. we retrospectively investigated the igm and igg antibodies to nine glycolipids [gm1, gm2, gm3, gd1a, gd1b, gd3, gt1b, gq1b, and gal-c (galactocerebroside)] and clinical features in neurological diseases associated with m. pneumoniae infection diagnosed in multiple hospitals throughout japan between september 2010 and march 2012. of the 46 pat ... | 2017 | 28025664 |
| mannose-binding lectin and l-ficolin polymorphisms in patients with community-acquired pneumonia caused by intracellular pathogens. | community-acquired pneumonia (cap) is the leading infectious disease requiring hospitalization in the western world. genetic variability affecting the host response to infection may play a role in susceptibility and outcome in patients with cap. mannose-binding lectin (mbl) and l-ficolin (l-fcn) are two important activators of the complement system and they can enhance phagocytosis by opsonization. in a prospective cohort of 505 dutch patients with cap and 227 control participants we studied whe ... | 2017 | 28032346 |
| clinical effect of treating secondary asthma attacks of children mycoplasma pneumoniae with combined therapy of montelukast and azithromycin. | to discuss the clinical effects of treating secondary asthma attacks of children mycoplasma pneumoniae with combined therapy of montelukast and azithromycin. | 2016 | 28051240 |
| increased serum interleukin-10 but not interleukin-4 level in children with mycoplasma pneumoniae pneumonia. | mycoplasma pneumoniae (mp) is a common cause of community-acquired pneumonia in children, and it has been associated with wheezing. the aim of this study was to examine the serum level of interleukin (il)-4 and il-10 in children with mycoplasma pneumoniae pneumonia (mpp) and to analyse them in relation to the presence of wheezing. | 2017 | 28057814 |
| epidemiology and molecular characteristics of mycoplasma pneumoniae during an outbreak of m. pneumoniae-associated stevens-johnson syndrome. | an increase in mycoplasma pneumoniae-associated stevens-johnson syndrome (sjs) cases at a colorado pediatric hospital led to an outbreak investigation. we describe the epidemiologic and molecular characteristics of m. pneumoniae among sjs case-patients and surrounding community members during the outbreak. | 2017 | 28060039 |
| a comprehensive analysis and immunobiology of autoimmune neurological syndromes during the zika virus outbreak in cúcuta, colombia. | we have focused on the epidemiology and immunobiology of zika virus (zikv) infection and factors associated with the development of guillain-barré syndrome (gbs) and other neurological syndromes in cúcuta, the capital of north santander department, colombia. data of patients with zikv disease reported to the national population-based surveillance system were used to calculate the basic reproduction number (r0) and the attack rates (ars) as well as to develop epidemiological maps. patients with n ... | 2017 | 28062188 |
| prevalence of chlamydophila pneumoniae and mycoplasma pneumoniae igm and igg antibodies in tunisian patients presenting with exacerbation of chronic obstructive pulmonary disease. | we aimed to assess the prevalence of chlamydophila pneumoniae and mycoplasma pneumoniae acute infections, using serological testing, in patients admitted to the emergency department for acute exacerbations of chronic obstructive pulmonary disease (copd). | 2017 | 28062246 |
| the effect of platycodin d on the expression of cytoadherence proteins p1 and p30 in mycoplasma pneumoniae models. | platycodin d is one of the most important monomers of the qinbaiqingfei pellet (qinbai), which has already been approved as the first effective new traditional chinese medicine used to fight against mycoplasma pneumoniae (m. pneumoniae) in clinic in china. in previous studies, pharmacodynamics experiment has proved that platycodin d has anti-m. pneumoniae effect and the minimum inhibitory concentration (mic) is 16mμg/ml. this paper further clarified that the mechanism underlying the anti-m. pneu ... | 2017 | 28073091 |
| in vitro antibacterial activity of α-methoxyimino acylide derivatives against macrolide-resistant pathogens and mutation analysis in 23s rrna. | we characterized in vitro activities of α-methoxyimino acylides against macrolide-resistant clinical isolates of streptococcus pneumoniae, streptococcus pyogenes and mycoplasma pneumoniae with ribosome modification or substitution and selected acylide-resistant mutants to clarify the binding point of the acylides. the acylides had low mics against erm(b) gene-containing s. pneumoniae and s. pyogenes (mic90s, 1-4 μg ml(-1)). for m. pneumoniae, although they had poor potencies against macrolide-re ... | 2017 | 28074049 |
| pseudotumour cerebri in children: aetiology, clinical features, and progression. | the definition, associated aetiologies, diagnosis, and treatment of idiopathic intracranial hypertension, or pseudotumour cerebri (ptc), are constantly being revised in the paediatric population. | 2017 | 28081975 |
| broad-range detection of microorganisms directly from bronchoalveolar lavage specimens by pcr/electrospray ionization-mass spectrometry. | the clinical demand on rapid microbiological diagnostic is constantly increasing. pcr coupled to electrospray ionization-mass spectrometry, pcr/esi-ms, offers detection and identification of over 750 bacteria and candida species directly from clinical specimens within 6 hours. in this study, we investigated the clinical performance of the iridica bac lrt assay for detection of bacterial pathogens in 121 bronchoalveolar lavage (bal) samples that were received consecutively at our bacterial labora ... | 2017 | 28085931 |
| changes in molecular characteristics of mycoplasma pneumoniae in clinical specimens from children in beijing between 2003 and 2015. | the molecular characteristics of 480 mycoplasma pneumoniae polymerase chain reaction-positive specimens (331 were previously reported and 149 were newly reported) collected from pediatric patients in beijing, china, between 2003 and 2015 were analyzed. genotype m4-5-7-2/p1 were the most prevalent across the 13-year study period, although the isolation and mutation rates for this genotype varied between the periods 2003-2007, 2008-2013, and 2014-2015. in addition, there was a close association be ... | 2017 | 28107399 |
| corrigendum to "imbalance of peripheral blood th17 and treg responses in children with refractory mycoplasma pneumoniae pneumonia" [j infect chemother 22 (2016) 162-166]. | 2017 | 28117170 | |
| acute respiratory distress syndrome related to mycoplasma pneumoniae infection. | m. pneumoniae respiratory infection is usually mild and self-limiting. we report a case of acute respiratory distress syndrome (ards) due to m. pneumoniae infection in a 60 years old woman. quick diagnosis was established by multiplex pcr assay for detection of pneumonia-causing bacteria. outcome was favorable. the factors accounting for the severity of pneumonia caused by m. pneumoniae are discussed. | 2017 | 28119816 |
| prospective etiological investigation of community-acquired pulmonary infections in hospitalized people living with hiv. | the study of the etiological agents of community-acquired pulmonary infections is important to guide empirical therapy, requires constant updating, and has a substantial impact on the prognosis of patients. the objective of this study is to determine prospectively the etiology of community-acquired pulmonary infections in hospitalized adults living with hiv. patients were submitted to an extended microbiological investigation that included molecular methods. the microbiological findings were eva ... | 2017 | 28121925 |
| [a case of bronchiolitis obliterans secondary to human metapneumovirus bronchiolitis]. | human metapneumovirus (hmpv), formerly classified in paramyxoviridae family is now moved into pneumoviridae, which was described as a novel family. it causes upper and lower respiratory tract infections (lrtis) usually in children younger than five years old. the recent epidemiological studies indicated that hmpv is the second most frequently detected virus in lrtis of young children, following the respiratory syncytial virus (rsv). bronchiolitis obliterans (bo) is a chronic obstructive lung dis ... | 2016 | 28124966 |
| high prevalence of mycoplasma pneumoniae and chlamydia pneumoniae in children with acute respiratory infections from lima, peru. | mycoplasma pneumoniae and chlamydia pneumoniae are atypical pathogens responsible for pneumonia and a leading cause of morbidity and mortality in low income countries. the study objective is to determine the prevalence of this pathogens in peruvian children with acute respiratory infections. | 2017 | 28129377 |
| effects of methylprednisolone or immunoglobulin when added to standard treatment with intravenous azithromycin for refractory mycoplasma pneumoniae pneumonia in children. | the prevalence of mycoplasma pneumoniae pneumonia has increased considerably in recent years. to evaluate the effi cacy of combined treatment of azithromycin with intravenous immunoglo-bulin (ivig) or methylprednisolone in children with refractory mycoplasma pneumoniae pneumonia (rmpp). | 2017 | 28130749 |
| differences in inflammatory marker patterns for adult community-acquired pneumonia patients induced by different pathogens. | the inflammatory marker patterns of community-acquired pneumonia (cap) induced by different microorganisms in adult patients remained unclear. | 2017 | 28139879 |
| a severe mycoplasma pneumoniae pneumonia inducing an acute antibody-mediated pulmonary graft rejection. | a 40-year-old cystic fibrosis woman with a history of double-lung transplantation 2 years previously was admitted for a progressive respiratory distress. physical examination revealed fever (39°c) and diffuse bilateral lung crackles. laboratory findings included severe hypoxemia and inflammatory syndrome. bronchoalveolar lavage and serological test were positive for mycoplasma pneumonia. as the patient did not improve after 3 days of antibiotics and donor-specific hla antibodies had been detecte ... | 2017 | 28144069 |
| pattern and significance of asymptomatic elevation of liver enzymes in mycoplasma pneumonia in children. | mycoplasma infection is on the rise in recent times. it usually infects any system, including liver. this study aims to show the significance of elevated liver enzymes in mycoplasma pneumonia and to have a look at future prospects. this is a single-center retrospective study involving 105 children serologically positive for mycoplasma igm and igg antibodies and 50 with community-acquired pneumonia caused by organisms other than mycoplasma and epstein-barr virus from june 2015 to june 2016 and al ... | 2017 | 28155329 |
| procalcitonin accurately identifies hospitalized children with low risk of bacterial community-acquired pneumonia. | lower procalcitonin (pct) concentrations are associated with reduced risk of bacterial community-acquired pneumonia (cap) in adults, but data in children are limited. | 2017 | 28158460 |
| a preliminary study on the potential of mycoplasma pneumoniae to induce dyskaryotic change in respiratory epithelium in adult community-acquired pneumonia. | this study aimed to explore the cellular morphology of respiratory epithelium in mycoplasma pneumonia (mpp) patients. | 2016 | 28163727 |
| diagnosis and treatment of mycoplasma pneumoniae in children. | mycoplasma pneumoniae is a common cause of community-acquired respiratory tract infections and accounts for up to 40% of cases of pneumonia in children over age 5. this article seeks to provide a general overview of the current recommended management of mycoplasma pneumoniae infection in children. | 2017 | 28178776 |
| etiology of severe pneumonia in ecuadorian children. | in latin america, community-acquired pneumonia remains a major cause of morbidity and mortality among children. few studies have examined the etiology of pneumonia in ecuador. | 2017 | 28182741 |
| prevalence of mycoplasma pneumoniae infection in malagasy children. | childhood community acquired pneumonia (cap) is a leading cause of childhood morbidity in low-income countries. the etiologic agents are usually staphylococcus aureus, streptococcus pneumoniae and mycoplasma pneumoniae. m. pneumoniae was recognized as co-factor in asthmatic disease. high asthma prevalence was reported in madagascar. our aim was to clarify the prevalence of m. pneumoniae infection in this country and its relationship with asthma. | 2017 | 28187063 |
| utility of assessing cytokine levels for the differential diagnosis of pneumonia in a pediatric population. | although pneumonia is easily diagnosed, determining the causative agent is difficult due to low pathogen detection rates. we performed a prospective observational study to evaluate the utility of measuring inflammatory cytokine levels to discriminate between pneumonia caused by typical bacteria, respiratory syncytial virus, or mycoplasma pneumoniae in a pediatric population. | 2017 | 28198756 |
| mycoplasma pneumoniae cards toxin elicits a functional ige response in balb/c mice. | mycoplasma pneumoniae is strongly associated with new onset asthma and asthma exacerbations. until recently, the molecular mechanisms utilized by m. pneumoniae to influence asthma symptoms were unknown. however, we recently reported that an adp-ribosylating and vacuolating toxin called the community acquired respiratory distress syndrome toxin, cards toxin, produced by m. pneumoniae was sufficient to promote allergic inflammation and asthma-like disease in mice. a mouse model of cards toxin expo ... | 2017 | 28199385 |
| the surface-displayed chaperones groel and dnak of mycoplasma pneumoniae interact with human plasminogen and components of the extracellular matrix. | 2017 | 28204467 | |
| autoimmunity in guillain-barré syndrome associated with zika virus infection and beyond. | autoimmune diseases share common immunopathogenic mechanisms (i.e., the autoimmune tautology), which explain the clinical similarities among them as well as their familial clustering. guillain-barré syndrome (gbs), an autoimmune peripheral neuropathy, has been recently associated with zika virus (zikv) infection. based on a series of cases, this review article provides a comparative analysis of gbs associated with zikv infection, contrasted with the general characteristics of gbs in light of the ... | 2017 | 28216074 |
| evaluation of rv0220, rv2958c, rv2994 and rv3347c of mycobacterium tuberculosis for serodiagnosis of tuberculosis. | tuberculosis (tb), the leading cause of death among infectious diseases worldwide, is caused by mycobacterium tuberculosis (m. tuberculosis). early accurate diagnosis means earlier prevention, treatment and control of tb. to confirm efficient diagnostic antigens for m. tuberculosis, the serodiagnosis value of four recombinant proteins including rv0220, rv2958c, rv2994 and rv3347c was evaluated in this study. the specificities and sensitivities of four recombinant proteins were determined based o ... | 2017 | 28217905 |
| a rare case of bilateral optic neuritis and guillain-barré syndrome post mycoplasma pneumoniae infection. | neurological complications are the most commonly encountered extra-pulmonary manifestation of infection with mycoplasma pneumoniae (m. pneumoniae). here the authors report the case of a 39-year-old woman who was admitted with acute-onset bilateral visual loss coinciding with ascending numbness. clinical examination, neurological imaging, and nerve conduction studies revealed a syndrome of bilateral optic neuritis and guillain-barré syndrome (gbs). serological testing confirmed recent exposure to ... | 2017 | 28228838 |
| complete genome sequence of mycoplasma pneumoniae type 2 reference strain fh using single-molecule real-time sequencing technology. | mycoplasma pneumoniae type 2 strain fh was previously sequenced with illumina (fh-illumina) and 454 (fh-454) technologies according to xiao et al. (2015) and krishnakumar et al. (2010). comparative analyses revealed differences in genomic content between these sequences, including a 6-kb region absent from the fh-454 submission. here, we present a complete genome sequence of fh sequenced with the pacific biosciences rsii platform. | 2017 | 28232437 |
| simultaneous detection of nine key bacterial respiratory pathogens using luminex xtag(®) technology. | early diagnosis and treatment are crucial to the outcome of lower respiratory tract infections (lrtis). in this study, we developed an assay combining multiplex pcr and luminex technology (mplt) for the detection of nine important respiratory bacterial pathogens, which frequently cause lrtis. these were streptococcus pneumoniae, moraxella catarrhalis, staphylococcus aureus, streptococcus pyogenes, haemophilus influenzae, mycoplasma pneumoniae, legionella spp., pseudomonas aeruginosa, and klebsie ... | 2017 | 28241513 |
| p40 and p90 from mpn142 are targets of multiple processing events on the surface of mycoplasma pneumoniae. | mycoplasma pneumoniae is a significant cause of community acquired pneumonia globally. despite having a genome less than 1 mb in size, m. pneumoniae presents a structurally sophisticated attachment organelle that (i) provides cell polarity, (ii) directs adherence to receptors presented on respiratory epithelium, and (iii) plays a major role in cell motility. the major adhesins, p1 (mpn141) and p30 (mpn453), are localised to the tip of the attachment organelle by the surface accessible cleavage f ... | 2015 | 28248283 |
| fluorocycline tp-271 is potent against complicated community-acquired bacterial pneumonia pathogens. | tp-271 is a novel, fully synthetic fluorocycline antibiotic in clinical development for the treatment of respiratory infections caused by susceptible and multidrug-resistant pathogens. tp-271 was active in mic assays against key community respiratory gram-positive and gram-negative pathogens, including streptococcus pneumoniae (mic90 = 0.03 µg/ml), methicillin-sensitive staphylococcus aureus (mssa; mic90 = 0.25 µg/ml), methicillin-resistant s. aureus (mrsa; mic90 = 0.12 µg/ml), streptococcus pyo ... | 2017 | 28251179 |
| defined chromosome structure in the genome-reduced bacterium mycoplasma pneumoniae. | dna-binding proteins are central regulators of chromosome organization; however, in genome-reduced bacteria their diversity is largely diminished. whether the chromosomes of such bacteria adopt defined three-dimensional structures remains unexplored. here we combine hi-c and super-resolution microscopy to determine the structure of the mycoplasma pneumoniae chromosome at a 10 kb resolution. we find a defined structure, with a global symmetry between two arms that connect opposite poles, one bear ... | 2017 | 28272414 |
| meteorological factors on the incidence of mp and rsv pneumonia in children. | pneumonia is common in children and mostly caused by many pathogens. the aim of this study was to investigate whether the incidence of pediatric mycoplasma pneumoniae (mp) pneumonia and respiratory syncytial virus (rsv) pneumonia was associated with meteorological factors in hangzhou, china. | 2017 | 28282391 |
| therapeutic efficacy of azithromycin, clarithromycin, minocycline and tosufloxacin against macrolide-resistant and macrolide-sensitive mycoplasma pneumoniae pneumonia in pediatric patients. | to clarify therapeutic effects of azithromycin, clarithromycin, minocycline and tosufloxacin against macrolide-resistant mycoplasma pneumoniae (mrmp) pneumonia and against macrolide-sensitive mycoplasma pneumoniae (msmp) pneumonia in pediatric patients. | 2017 | 28288170 |
| transcriptome analysis of bronchoalveolar lavage fluid from children with severe mycoplasma pneumoniae pneumonia reveals novel gene expression and immunodeficiency. | a growing number of severe mycoplasma pneumoniae pneumonia (mpp) cases have been reported recently. however, the pathogenesis of severe mpp is not clear. in the current study, transcriptome sequencing was used to identify gene expression and alternative splicing profiles to provide insights into the pathogenesis of severe mpp. | 2017 | 28302172 |
| diagnostic value of nasopharyngeal aspirates in children with lower respiratory tract infections. | the accuracy of nasopharyngeal aspirate (npa) specimens in detecting lower respiratory pathogens remains controversial. the objective of this study was to evaluate the diagnostic accuracy of aspirates (npas) specimen in lower respiratory tract infections (lrtis) in children. | 2017 | 28303845 |
| multi-center evaluation of one commercial and 12 in-house real-time pcr assays for detection of mycoplasma pneumoniae. | detection of mycoplasma pneumoniae by real-time pcr is not yet standardized across laboratories. we have implemented a standardization protocol to compare the performance of thirteen commercial and in-house approaches. despite differences on threshold values of samples, all assays were able to detect at least 20m. pneumoniae genomes per reaction. | 2017 | 28318608 |
| isolated optic neuritis associated with mycoplasma pneumoniae infection: report of two cases and literature review. | mycoplasma pneumonia is a major pathogen of primary atypical pneumonia and has been known to cause various kinds of extrapulmonary manifestations involving almost all organs of the human body. optic neuritis associated with m. pneumoniae infection has rarely been described and mostly, it combined other neurological complications including meningitis, meningoencephalitis, myelitis, and peripheral neuropathy. we report two patients who presented with isolated optic neuritis due to m. pneumoniae in ... | 2017 | 28321515 |
| acute pancreatitis caused by mycoplasma pneumoniae: an unusual etiology. | it is well known that the most important etiologies of acute pancreatitis are gallstones and alcohol consumption. once these causes have been ruled out, especially in young adults, it is important to consider less frequent etiologic factors such as drugs, trauma, malformations, autoimmunity or systemic diseases. other rare and less well studied causes of this pathology are infections, among which mycoplasma pneumoniae has been reported to cause acute pancreatitis as an unusual extrapulmonary man ... | 2017 | 28324273 |
| familial acute necrotizing encephalopathy with ranbp2 mutation: the first report in northeast asia. | acute necrotizing encephalopathy (ane) is a rare but rapidly progressing encephalopathy following a febrile illness, commonly a viral infection. it is characterized by the features of acute encephalopathy such as seizure, alteration of consciousness, and symmetric involvement of the bilateral thalamus on neuroimaging tests. although most ane cases have occurred sporadically, familial or recurrent ane has been reported in caucasian patients, with genetic susceptibility to ane noted in some patien ... | 2017 | 28336122 |
| comparison of the protective effects of individual components of particulated trans-sialidase (ptcts), ptc and ts, against high cholesterol diet-induced atherosclerosis in rabbits. | previous studies showed the presence of mycoplasma pneumoniae (m. pneumoniae) and membrane-shed microparticles (mps) in vulnerable atherosclerotic plaques. h&s science and biotechnology developed ptcts, composed by natural particles from medicinal plants (ptc) combined with trans-sialidase (ts), to combat mps and mycoplasma pneumoniae. our aim was to determine the effects of the different components of ptcts in a rabbit model of atherosclerosis. rabbits were fed with high cholesterol diet for 12 ... | 2017 | 28337456 |
| clinical evaluation of a new single-tube multiplex reverse transcription pcr assay for simultaneous detection of 11 respiratory viruses, mycoplasma pneumoniae and chlamydia in hospitalized children with acute respiratory infections. | respiratory pathogen 13 detection kit (13× kit) is able to simultaneously detect 11 respiratory viruses, mycoplasma pneumoniae (mp) and chlamydia in a single reaction. using 572 nasopharyngeal aspirates collected from hospitalized children, the clinical performance of 13× kit for detecting 11 respiratory viruses was evaluated in comparison with a routinely used 2-tube multiplex reverse transcription pcr assay (2-tube assay) at provincial centers for disease control and prevention in china. the c ... | 2017 | 28365060 |
| [fatal swine influenza a h1n1 and mycoplasma pneumoniae coinfection in a child]. | one of the most common causes of death in influenza patients is secondary bacterial pneumonia and the most common pathogens involved are streptococcus pneumoniae, staphylococcus aureus, and haemophilus influenza. to diagnose co infection with bacteria in a h1n1 case can be difficult but should be strongly suspected in a child who present with influenza like illness and lower respiratory tract signs or symptoms. we report coinfection of mycoplasma pneumoniae in swine influenza a h1n1 child who pr ... | 2016 | 28366159 |
| the variable internal structure of the mycoplasma penetrans attachment organelle revealed by biochemical and microscopic analyses: implications for attachment organelle mechanism and evolution. | although mycoplasmas have small genomes, many of them, including the hiv-associated opportunist mycoplasma penetrans, construct a polar attachment organelle (ao) used for both adherence to host cells and gliding motility. however, the irregular phylogenetic distribution of similar structures within the mycoplasmas as well as compositional and ultrastructural differences among these aos suggest that aos have arisen several times by convergent evolution. we investigated the ultrastructure and prot ... | 2017 | 28373274 |
| prevalence of atypical pathogens in patients with cough and community-acquired pneumonia: a meta-analysis. | community-acquired pneumonia (cap), acute cough, bronchitis, and lower respiratory tract infections (lrti) are often caused by infections with viruses or streptococcus pneumoniae. the prevalence of atypical pathogens mycoplasma pneumoniae, chlamydophila pneumoniae, legionella pneumophila, and bordetella pertussis among patients with these illnesses in the ambulatory setting has not been previously summarized. we set out to derive prevalence information from the existing literature. | 2016 | 28376442 |
| fatal swine influenza a h1n1 and mycoplasma pneumoniae coinfection in a child. | one of the most common causes of death in influenza patients is secondary bacterial pneumonia and the most common pathogens involved are streptococcus pneumoniae, staphylococcus aureus, and haemophilus influenza. to diagnose co infection with bacteria in a h1n1 case can be difficult but should be strongly suspected in a child who present with influenza like illness and lower respiratory tract signs or symptoms. we report coinfection of mycoplasma pneumoniae in swine influenza a h1n1 child who pr ... | 2016 | 28393730 |
| [importance of respiratory virus in immunocompetent adult patients hospitalized with community-acquired pneumonia]. | community-acquired pneumonia (cap) is a relevant worldwide cause of morbidity and mortality in adult population, however its etiology is often not identified and therapy is empirical. | 2016 | 28393985 |
| prevalence of mycoplasma pneumoniae infection in malagasy children. | childhood community-acquired pneumonia is a leading cause of childhood morbidity in low-income countries. the etiologic agents are usually staphylococcus aureus, streptococcus pneumoniae and mycoplasma pneumoniae. m. pneumoniae was recognized as a cofactor in asthmatic disease. high asthma prevalence was reported in madagascar. our aim was to clarify the prevalence of m. pneumoniae infection in this country and its relationship with asthma. | 2017 | 28403048 |
| association of the ace, gstm1, il-6, nos3, and cyp1a1 polymorphisms with susceptibility of mycoplasma pneumoniae pneumonia in chinese children. | mycoplasma pneumoniae is a common cause of community-acquired pneumonia (cap) and the clinical presentation of mycoplasma pneumoniae pneumonia (mpp) varies widely. genetic variability affecting the host response may also influence the susceptibility to mpp. several studies have investigated the association between single nucleotide polymorphism (snp) of some genes and the risks of cap; however, the results were inconsistent. here, we investigated the association of 5 functional genes and the ris ... | 2017 | 28403117 |
| evaluation of a taqman array card for detection of central nervous system infections. | infections of the central nervous system (cns) are often acute, with significant morbidity and mortality. routine diagnosis of such infections is limited in developing countries and requires modern equipment in advanced laboratories that may be unavailable to a number of patients in sub-saharan africa. we developed a taqman array card (tac) that detects multiple pathogens simultaneously from cerebrospinal fluid. the 21-pathogen cns multiple-pathogen tac (cns-tac) assay includes two parasites (ba ... | 2017 | 28404679 |
| comprehensive bioinformatics analysis of mycoplasma pneumoniae genomes to investigate underlying population structure and type-specific determinants. | mycoplasma pneumoniae is a significant cause of respiratory illness worldwide. despite a minimal and highly conserved genome, genetic diversity within the species may impact disease. we performed whole genome sequencing (wgs) analysis of 107 m. pneumoniae isolates, including 67 newly sequenced using the pacific biosciences rs ii and/or illumina miseq sequencing platforms. comparative genomic analysis of 107 genomes revealed >3,000 single nucleotide polymorphisms (snps) in total, including 520 ty ... | 2017 | 28410368 |
| an interesting case of mycoplasma pneumonia associated multisystem involvement and diffuse alveolar hemorrhage. | severe mycoplasma pneumonia is a rare entity with only 0.5-2% of cases having a fulminant course. we present a 74-year-old woman with hypertension, diabetes mellitus and remote history of marginal zone b-cell lymphoma admitted with abdominal pain and diarrhea of 1-2 days associated with body-aches, dyspnea, dry cough and weight loss for 2-3 weeks. on physical exam, she was febrile, tachypneic, tachycardic and hypoxic on room air. chest examination revealed diffuse crackles and end-expiratory whe ... | 2017 | 28413775 |
| nrf2 regulates the inflammatory response, including heme oxygenase-1 induction, by mycoplasma pneumoniae lipid-associated membrane proteins in thp-1 cells. | a series of inflammatory responses caused by mycoplasma pneumoniae largely depend on the lipid-associated membrane proteins (lamps). nuclear factor e2-related factor 2 (nrf2), a transcription factor, is considered to be a critical modulator of inflammatory responses and cellular redox homeostasis. monocytes play an important role in the invasion and immunity to resist pathogens. here, we investigated the role of nrf2 in the anti-inflammatory response stimulated by lamps using the human monocyte ... | 2017 | 28430965 |
| infectious agents is a risk factor for myxomatous mitral valve degeneration: a case control study. | the etiology of myxomatous mitral valve degeneration (mvd) is not fully understood and may depend on time or environmental factors for which the interaction of infectious agents has not been documented. the purpose of the study is to analyze the effect of mycoplasma pneumoniae (mp), chlamydophila pneumoniae (cp) and borrelia burgdorferi (bb) on myxomatous mitral valve degeneration pathogenesis and establish whether increased in inflammation and collagen degradation in myxomatous mitral valve deg ... | 2017 | 28431520 |
| inflammatory responses regulating alveolar ion transport during pulmonary infections. | the respiratory epithelium is lined by a tightly balanced fluid layer that allows normal o2 and co2 exchange and maintains surface tension and host defense. to maintain alveolar fluid homeostasis, both the integrity of the alveolar-capillary barrier and the expression of epithelial ion channels and pumps are necessary to establish a vectorial ion gradient. however, during pulmonary infection, auto- and/or paracrine-acting mediators induce pathophysiological changes of the alveolar-capillary barr ... | 2017 | 28458673 |
| mycoplasma pneumoniae: a cross-sectional population-based comparison of disease severity in pre-school and school-age children. | mycoplasma pneumoniae (mp) causes epidemics of upper respiratory disease and pneumonia. it is thought that mp usually causes milder upper respiratory disease in pre-school children, with a greater chance of pneumonia in school-age children. in this population-based cross-sectional study, we present evidence that severe mp infection is more common in pre-school children than previously thought. | 2017 | 28471864 |
| evolution of acute infection with atypical bacteria in a prospective cohort of children with community-acquired pneumonia receiving amoxicillin. | atypical bacteria are treatable causative agents of community-acquired pneumonia (cap). however, there is no conclusive evidence that a child with cap should receive empirical treatment against such agents. | 2017 | 28475737 |
| influence of antibiotics on the detection of bacteria by culture-based and culture-independent diagnostic tests in patients hospitalized with community-acquired pneumonia. | specimens collected after antibiotic exposure may reduce culture-based bacterial detections. the impact on culture-independent diagnostic tests is unclear. we assessed the effect of antibiotic exposure on both of these test results among patients hospitalized with community-acquired pneumonia (cap). | 2017 | 28480285 |
| molecular characterization of mycoplasma pneumoniae infections in two rural populations of thailand from 2009 to 2012. | studies on mycoplasma pneumoniae in thailand have focused on urban centers and have not included molecular characterization. in an attempt to provide a more comprehensive understanding of this organism, we conducted a systematic random sampling to identify 3,000 nasopharyngeal swab specimens collected from january 2009 through july 2012 during population-based surveillance for influenza-like illness in two rural provinces. m. pneumoniae was detected by real-time pcr in 175 (5.8%) specimens. geno ... | 2017 | 28490485 |
| the seroprevalence of mycoplasma pneumoniae igm and igg antibodies in patients with ischemic stroke. | association between mycoplasma pneumoniae infection and increased risk for brain stroke has been well understood. hence, the value of serologic tests for assessing causative relationship between this infection and brain stroke seems to be high. the present study aimed to determine serum level of anti-mycoplasma pneumoniae antibodies in patients with brain stroke and to compare it with non-stroke patients. | 2016 | 28491249 |
| versatile methodology for glycosurfaces: direct ligation of nonderivatized reducing saccharides to poly(pentafluorophenyl acrylate) grafted surfaces via hydrazide conjugation. | in this work, we report a convenient and versatile strategy for surface-grafted glycopolymer constructs with the goal of surface modification that controls the chemical presentation and grafting density of carbohydrate side chains. this approach employs a difunctional hydrazine linker, chemically modified to an active ester containing poly(pentafluorophenyl acrylate) grafted scaffold, to conjugate a variety of saccharides through the reducing end. the successive conjugation steps are carried out ... | 2017 | 28492327 |
| development of immunochromatographic colloidal gold test strip for rapid detection of haemophilus influenzae in clinical specimens. | a simple and fast test strip for simultaneous detection of haemophilus influenzae, based on the theory of colloidal gold immunochromatography was developed. | 2017 | 28497596 |
| macrolide resistance and its impacts on m. pneumoniae pneumonia in children: comparison of two recent epidemics in korea. | the aim of this study was to investigate the change in macrolide resistance rate in pediatric mycoplasma pneumoniae pneumonia and to evaluate the influence of macrolide-resistant m. pneumoniae (mrmp) on the clinical course of disease, by comparing 2 recent, consecutive epidemics in korea. | 2017 | 28497921 |
| encephalopathy and axonal neuropathy associated with mycoplasma pneumoniae infection: response to intravenous immunoglobulin therapy. | mycoplasma pneumoniae infection frequently presents as a self-limited process, however, severe cases and even fatalities have been reported. the authors present a case of mycoplasma pneumoniae infection associated with both encephalopathy and peripheral neuropathy that responded to intravenous immunoglobulin therapy. to our knowledge, this is the first documented case of mycoplasma pneumoniae related to encephalitis and peripheral axonal neuropathy. to date, there is insufficient data on the eff ... | 2017 | 28503607 |
| histological findings in severe mycoplasma pneumoniae pneumonia. | 2017 | 28513419 | |
| delayed stevens-johnson syndrome secondary to the use of lamotrigine in bipolar mood disorder. | lamotrigine is a mood-stabilizing drug used in maintenance treatment of bipolar i disease. there are adverse effects with lamotrigine such as a headache, blurred vision, diplopia, somnolence, ataxia, dizziness, rash, stevens-johnson syndrome (sjs), and toxic epidermal necrolysis. sjs is a life-threatening, blistering mucocutaneous disease. sjs is characterized by the presence of flat, diffuse erythematous maculopapular rashes with the involvement of <10% of the body surface area. standard trigge ... | 2017 | 28515564 |
| evaluation of a real-time method of simultaneous amplification and testing in diagnosis of mycoplasma pneumoniae infection in children with pneumonia. | mycoplasma pneumoniae (m. pneumoniae) infection can cause community acquired pneumonia in children. a real-time method of simultaneous amplification and testing of m. pneumoniae (sat-mp) was developed to diagnose m. pneumoniae targeting a region of the ribosomal rna. the sat-mp assay can accurately identify m. pneumoniae with a detection range from 101 to 107 cfu/ml. in this study, the specimens from 315 children with pneumonia were collected and analyzed by sat-mp in parallel with real-time pcr ... | 2017 | 28520818 |
| [bronchopulmonary infections caused by atypical pathogens in children : myth or reality?] | mycoplasma pneumoniae and chlamydia pneumoniae are the most common atypical pathogens seen in respiratory infections in children. currently, the management of atypical pneumonia due to these pathogens is blurry. the clinical features are hardly specific ; it appears that m. pneumoniae respiratory infect ions are associated with chest pain and the absence of wheezing, however, further confirmations are needed. hoarseness is frequently seen with c. pneumoniae infection. co-infections with viruses, ... | 2016 | 28525234 |
| mycoplasma pneumoniae from the respiratory tract and beyond. | mycoplasma pneumoniae is an important cause of respiratory tract infections in children as well as adults that can range in severity from mild to life-threatening. over the past several years there has been much new information published concerning infections caused by this organism. new molecular-based tests for m. pneumoniae detection are now commercially available in the united states, and advances in molecular typing systems have enhanced understanding of the epidemiology of infections. more ... | 2017 | 28539503 |
| whole genome analysis reveals new insights into macrolide resistance in mycoplasma pneumoniae. | mutations in 23s rrna gene are known to be associated with macrolide resistance in mycoplasma pneumoniae (m. pneumoniae). however, these mutations alone do not fully explain the high resistance rates in asia. the aim of this study was to investigate other possible mutations involved in macrolide resistance in m. pneumoniae. | 2017 | 28549490 |
| mycoplasma pneumoniae-induced rash and mucositis (mirm): an unusual mild skin rash associated with severe mucosal involvement. | 2017 | 28551607 | |
| fuchs syndrome: medical treatment of 1 case and literature review. | fuchs syndrome is a particular type of erythema multiforme major; the lesions are only found on the mucosae and specifically affect oral, ocular, and genital mucosae. the cause is not always immediately apparent, which is why this pathology requires a rigorous, detailed clinical examination to eliminate a differential diagnosis. the severity of the symptoms, particularly of oral and ocular symptoms, requires immediate treatment. the treatment of this pathology requires a multiple-drug regime. th ... | 2017 | 28559809 |
| life-threatening pneumopathy and u urealyticum in a stat3-deficient hyper-ige syndrome patient. | a deficiency in signal transducer and activator of transcription 3 (stat3) is responsible for autosomal dominant hyperimmunoglobulin e syndrome, an immunodeficiency syndrome causing staphylococcus aureus, streptococcus pneumonia, haemophilus influenzae, and, rarely, pseudomonas aeruginosa and aspergillus sp infections. currently, intracellular pathogens are not targeted in the management of severe infections. the pathophysiologic mechanism of hyperimmunoglobulin e syndrome immunodeficiency has r ... | 2017 | 28562253 |
| association of mycoplasma pneumoniae infection with increased risk of asthma in children. | the present study was conducted to investigate the relationship between mycoplasma pneumoniae (mp) infection and the risk of asthma among children by detecting the rate of mp immunoglobulin m (mp-igm) and the eosinophil (eos) count. a total of 139 asthmatic children were enrolled as the case group and assigned into three groups: group a (aged <3 years, n=42), group b (aged 3-8 years, n=45) and group c (aged >8 years, n=52). additionally, 115 healthy children were enrolled in the control group. e ... | 2017 | 28565772 |
| mucositis secondary to chlamydia pneumoniae infection: expanding the mycoplasma pneumoniae-induced rash and mucositis concept. | the term mycoplasma pneumoniae-induced rash and mucositis (mirm) was recently proposed to identify the mucocutaneous condition secondary to m. pneumoniae infection that had historically been regarded among the more confusing pathologies of erythema multiforme and stevens-johnson syndrome. based on a number of previous reports, these syndromes require differentiation since they have different prognoses and specific treatment requirements. we report a case of oral and genital erosions that strongl ... | 2017 | 28568680 |
| killing kinetics of minocycline, doxycycline and tosufloxacin against macrolide-resistant mycoplasma pneumoniae. | macrolide-resistant mycoplasma pneumoniae (mrmp) has emerged and is increasing worldwide. in a 2011 outbreak of mrmp infections in japan, symptoms failed to improve in many patients who initially received macrolides; the therapeutic agent was then changed to minocycline (min), doxycycline (dox) or tosufloxacin (tfx). in this study, the bactericidal effects of these three agents against mrmp were evaluated. time-kill kinetics against mrmp and macrolide-susceptible m. pneumoniae (msmp) were determ ... | 2017 | 28579455 |
| radiologic findings as a determinant and no effect of macrolide resistance on clinical course of mycoplasma pneumoniae pneumonia. | with the emergence of macrolide resistance, concerns about the efficacy of macrolides for the treatment of mycoplasma pneumoniae (mp) pneumonia in children have been raised. this study aimed to determine the effect of macrolide resistance on the outcome of children who were hospitalized with mp pneumonia. | 2017 | 28592263 |
| prevalence and clinical manifestations of macrolide resistant mycoplasma pneumoniae pneumonia in korean children. | macrolide resistance rate of mycoplasma pneumoniae has rapidly increased in children. studies on the clinical features between macrolide susceptible-m. pneumoniae (msmp) and macrolide resistant-m. pneumoniae (mrmp) are lacking. the aim of this study was to identify the macrolide resistance rate of m. pneumoniae in korean children with m. pneumoniae penupmonia in 2015 and compare manifestations between msmp and mrmp. | 2017 | 28592978 |
| macrolide therapy for community-acquired pneumonia due to atypical pathogens: outcome assessment at an early time point. | therapy directed against atypical pathogens in patients with community-acquired pneumonia (cap) is often recommended. this post-hoc analysis evaluated the effect of addition of a macrolide to ceftaroline fosamil or ceftriaxone treatment in atypical cap. | 2017 | 28599867 |
| microorganisms associated with pneumonia in children <5 years of age in developing and emerging countries: the gabriel pneumonia multicenter, prospective, case-control study. | pneumonia, the leading infectious cause of child mortality globally, mainly afflicts developing countries. this prospective observational study aimed to assess the microorganisms associated with pneumonia in children aged <5 years in developing and emerging countries. | 2017 | 28605562 |
| peculiar cold-induced leukoagglutination in mycoplasma pneumoniae pneumonia. | 2017 | 28611012 |