Publications

TitleAbstractYear
Filter
PMID(sorted ascending)
Filter
laboratory-based surveillance of pertussis using multitarget real-time pcr in japan: evidence for bordetella pertussis infection in preteens and teens.between january 2013 and december 2014, we conducted laboratory-based surveillance of pertussis using multitarget real-time pcr, which discriminates among bordetella pertussis, bordetella parapertussis, bordetella holmesii and mycoplasma pneumoniae. of 355 patients clinically diagnosed with pertussis in japan, b. pertussis, b. parapertussis and m. pneumoniae were detected in 26% (n = 94), 1.1% (n = 4) and 0.6% (n = 2), respectively, whereas b. holmesii was not detected. it was confirmed that b.  ...201527076914
acute mycoplasma pneumoniae infection presenting with unilateral anterior uveitis and perineuritis.we report a case of confirmed mycoplasma pneumoniae infection in the setting of unilateral anterior uveitis and perineuritis without coexisting systemic manifestations. we hypothesize a causal association between acute m. pneumoniae infection and this patient's ocular presentation. delay in identification of m. pneumoniae infection in this case prompted treatment with systemic and topical steroids for presumed autoimmune etiology. the rapid resolution of symptoms without concurrent antibiotic tr ...201627079602
relationship among chlamydia and mycoplasma pneumoniae seropositivity, ikzf1 genotype and chronic obstructive pulmonary disease in a general japanese population: the nagahama study.chronic obstructive pulmonary disease (copd) is a possible risk factor for cardiovascular disease. the association of copd with the pathogenicity of infection with chlamydia pneumoniae and mycoplasma pneumoniae is controversial. we conducted a cross-sectional study to clarify the association between atypical pneumoniae seropositivity and copd in a general population. we also investigated genetic polymorphisms conferring susceptibility to a pneumonia titer. the study included 9040 japanese subjec ...201627082601
[a case of eosinophilic bronchiolitis complicated with bronchial asthma and chronic eosinophilic pneumonia].a 62-year-old man was admitted to our hospital because of wheezing and dyspnea. chest computed tomography showed ground-glass opacity and some centrilobular nodules. chronic eosinophilic pneumonia complicated with mycoplasma pneumoniae infection was diagnosed on the basis of bronchoalveolar lavage eosinophilia and blood findings. however, based on the clinical course, the patient was suspected to have eosinophilic bronchiolitis. this case suggests the possibility that eosinophilic inflammation c ...201627086960
rapid and combined detection of mycoplasma pneumoniae, epstein-barr virus and human cytomegalovirus using allglo quadruplex quantitative pcr.acute respiratory infections (aris) cause substantial morbidity and mortality worldwide. the causes of ari are dynamic, and co-infections of mycoplasma pneumoniae, epstein-barr virus and human cytomegalovirus are recently developed causes of ari. here, we established a quadruplex quantitative pcr (qpcr) method to rapidly identify and simultaneously detect a single infection or co-infection of these three pathogens and an internal control in a single tube using allglo probes. the analysis demonst ...201627093597
is there any relationship between extra-pulmonary manifestations of mycoplasma pneumoniae infection and atopy/respiratory allergy in children?mycoplasma pneumoniae is a common cause of respiratory infections in children, but sometimes extra-pulmonary diseases can be observed. the immunological mechanisms involved in these extra-respiratory complications are unknown. here, we report a small case series of mycoplasma-related diseases including 5 children who developed: i) aseptic meningitis; ii) urticarial rash and pericardial effusion; iii) pleural effusion with severe eosinophilia; iv) stevens-johnson syndrome; v) multiform erythema. ...201627114818
chlamydia pneumoniae, and mycoplasma pneumoniae: are they related to severe asthma in childhood?mycoplasma pneumoniae and chlamydia pneumoniae are frequent agents of acute respiratory diseases and they have been recognized as infectious triggers of asthma.201627120360
bilateral intermediate uveitis with appearance of frosted branch angiitis and association with mycoplasma pneumoniae infection: case report and review of the literature.a 12-year-old girl presented with acute bilateral visual loss following a mild upper respiratory tract infection. clinical examination revealed bilateral severe peripheral retinal vasculitis with an appearance of frosted branch angiitis and cystoid macular edema. all tests for etiological diagnosis were negative, apart from positive igm and igg antibodies for mycoplasma pneumoniae. she was treated with broad-spectrum antibiotics and intravenous corticosteroids. she responded to treatment, with d ...201627132140
designing, expression and immunological characterization of a chimeric protein of mycoplasma pneumoniae.mycoplasma pneumoniae is thought to be the simplest and smallest cell wall-deficient bacterium which can cause chronic respiratory infections. recently vaccination has been a possible and reliable way to reduce the spreading and infection effectively. in this study, the transmembrane proteins p116n (the n-terminal of p116), p1c (the c-terminal of p1), p30, and p116n-p1c-p30 (mp559 for short), a chimeric protein were expressed using prokaryotic expression system. the four purified recombinant pro ...201627137129
a compendium for mycoplasma pneumoniae.historically, atypical pneumonia was a term used to describe an unusual presentation of pneumonia. currently, it is used to describe the multitude of symptoms juxtaposing the classic symptoms found in cases of pneumococcal pneumonia. specifically, atypical pneumonia is a syndrome resulting from a relatively common group of pathogens including chlamydophila sp., and mycoplasma pneumoniae. the incidence of m. pneumoniae pneumonia in adults is less than the burden experienced by children. transmiss ...201627148202
study of two separate types of macrolide-resistant mycoplasma pneumoniae outbreaks.to study the complete natural process of a mycoplasma pneumoniae outbreak in a semiclosed room such as a primary school room, we investigated two separate m. pneumoniae outbreaks involving 81 students in total in two primary schools in hangzhou, china. m. pneumoniae isolates from pharyngeal swabs were detected by fluorescence quantitative real-time pcr (rt-pcr) and culture. the class in school m had 39 students, with 12 (30.8%) with positive m. pneumoniae detection results. the class from school ...201627161643
acute respiratory distress syndrome caused by mycoplasma pneumoniae without elevated pulmonary vascular permeability: a case report.sporadic patients with acute respiratory distress syndrome (ards) caused by mycoplasma pneumoniae have been reported. however, knowledge about the pathophysiology and pharmacological treatment of this condition is insufficient. moreover, the pulmonary vascular permeability in ards related to m. pneumoniae infection has not been reported. we report a case of ards caused by mycoplasma pneumoniae without elevated pulmonary vascular permeability, which was successfully treated using low-dose short-t ...201627162691
an atypical case of hemoptysis.hemoptysis, a common sign of diffuse alveolar hemorrhage, can be caused by multiple factors, both infectious and noninfectious. a 45-year-old male with hypertension, obstructive sleep apnea, and stage iv pulmonary sarcoidosis with cardiac involvement, presented with a two-month history of cough and acute nonmassive hemoptysis with hypoxia. a chest ct showed ground glass consolidation and interlobular septal thickening, concerning for diffuse alveolar hemorrhage. flexible bronchoscopy confirmed d ...201627169298
molecular identification and epidemiological features of human adenoviruses associated with acute respiratory infections in hospitalized children in southern china, 2012-2013.acute respiratory infections (ari) are the major worldwide health problem associated with high morbidity and mortality rates. human adenovirus (hadv) is one of the most common pathogens associated with viral ari, and thus calls for specific diagnosis and better understanding of the epidemiology and clinical characteristics.201627171486
early serologic diagnosis of mycoplasma pneumoniae pneumonia: an observational study on changes in titers of specific-igm antibodies and cold agglutinins.there have been some limitations on early diagnosis of mycoplasma pneumoniae (mp) infection because of no immunoglobulin m (igm) responses and variable detection rates of polymerase chain reaction in the early stage of the disease. we wanted to discuss regarding early diagnostic method using short-term paired titration of mp-specific igm and cold agglutinins (cas) in the early stage of mp pneumonia.the participants of this study were 418 children with mp pneumonia during 2 recent epidemics (2006 ...201627175666
insights on the virulence of swine respiratory tract mycoplasmas through genome-scale metabolic modeling.the respiratory tract of swine is colonized by several bacteria among which are three mycoplasma species: mycoplasma flocculare, mycoplasma hyopneumoniae and mycoplasma hyorhinis. while colonization by m. flocculare is virtually asymptomatic, m. hyopneumoniae is the causative agent of enzootic pneumonia and m. hyorhinis is present in cases of pneumonia, polyserositis and arthritis. the genomic resemblance among these three mycoplasma species combined with their different levels of pathogenicity ...201627178561
simulated acute central mycoplasma infections in rats induce fever, anorexia, body mass stunting and lethargy but spare memory.despite the documented post-infectious neurological complications of a central nervous system (cns) mycoplasma infection in humans, very few studies have investigated the acute inflammatory responses and sickness behaviours induced by cns mycoplasma infections. we therefore determined the effect of acute central administration of fibroblast-stimulating lipopeptide-1 (fsl-1), derived from mycoplasma salivarium, and fam-20 from a more pathogenic species, namely mycoplasma pneumoniae, on behavioura ...201627180133
roles of t-cell immunoglobulin and mucin domain genes and toll-like receptors in wheezy children with mycoplasma pneumoniae pneumonia.the study aimed to explore possible factors influencing wheezing in children with mycoplasma pneumoniae pneumonia (mpp).201627185658
complete occlusion of the right middle cerebral artery associated with mycoplasma pneumoniae pneumonia.we report a case of a 5-year-old girl who developed left hemiparesis and left facial palsy, 6 days after the initiation of fever and respiratory symptoms due to pneumonia. chest radiography, conducted upon admission, showed pneumonic infiltration and pleural effusion in the left lung field. brain magnetic resonance imaging showed acute ischemic infarction in the right middle cerebral artery territory. brain magnetic resonance angiography and transfemoral cerebral angiography revealed complete oc ...201627186223
optic neuritis as a presenting symptom of mycoplasma pneumoniae infection.a broad range of neurologic disorders has been described in children infected with mycoplasma pneumoniae, of which encephalitis is among the most common. in contrast, the association between optic neuritis and mycoplasma pneumoniae infection has been rarely described in children. we report a case of a 12-year-old girl who was seropositive for antibodies against mycoplasma pneumoniae and presented with optic neuritis without respiratory symptoms or other neurologic findings.201727186706
increased concentrations of soluble b7-h3 and interleukin 36 in bronchoalveolar lavage fluid of children with mycoplasma pneumoniae pneumonia.the purpose of this study is to explore the correlations of interleukin 36 (il-36) and soluble b7-h3 (sb7-h3) levels in bronchoalveolar lavage fluid (balf) with clinical characteristics and laboratory findings.201627188891
identification of bacterial and viral codetections with mycoplasma pneumoniae using the taqman array card in patients hospitalized with community-acquired pneumonia.mycoplasma pneumoniae was detected in a number of patients with community-acquired pneumonia in a recent prospective study. to assess whether other pathogens were also detected in these patients, taqman array cards were used to test 216 m pneumoniae-positive respiratory specimens for 25 additional viral and bacterial respiratory pathogens. it is interesting to note that 1 or more codetections, predominantly bacterial, were identified in approximately 60% of specimens, with codetections being mor ...201627191004
severe pneumonia by mycoplasma as an adverse event of everolimus therapy in patients with tuberous sclerosis complex.epilepsy is one of the most common symptoms in tuberous sclerosis complex (tsc), appearing mainly in the first year of life and often resistant to therapy. several studies have demonstrated the effectiveness of everolimus but its safety in children has not yet been well reported. we present two cases of severe pneumonia caused by mycoplasma in two children receiving everolimus for epilepsy secondary to tsc.201627215926
the clinical characteristics and predictors of refractory mycoplasma pneumoniae pneumonia in children.to analyze the clinical characteristics of refracory mycoplasma pneumoniae pneumonia (rmpp), and explore the related factors predicting rmpp.201627227519
clinically mild encephalitis/encephalopathy with a reversible splenial lesion associated with mycoplasma pneumoniae infection.clinically mild encephalitis/encephalopathy with a reversible splenial lesion (mers) is a clinico-radiological syndrome characterized by transient mild symptoms of encephalopathy and a reversible lesion in the splenium of the corpus callosum on magnetic resonance imaging (mri). it is often triggered by infection. the common pathogens of mers are viruses, especially influenza virus. however, mycoplasma pneumoniae (m.pneumoniae) are relatively rare pathogens for mers.201627230114
insights into the mechanisms of basal coordination of transcription using a genome-reduced bacterium.coordination of transcription in bacteria occurs at supra-operonic scales, but the extent, specificity, and mechanisms of such regulation are poorly understood. here, we tackle this problem by profiling the transcriptome of the model organism mycoplasma pneumoniae across 115 growth conditions. we identify three qualitatively different levels of co-expression corresponding to distinct relative orientations and intergenic properties of adjacent genes. we reveal that the degree of co-expression bet ...201627237741
increased frequency of th17 cells in children with mycoplasma pneumoniae pneumonia.mycoplasma pneumoniae (m. pneumoniae, mp) is recognized globally as a significant cause of primary atypical pneumonia in humans, particularly in children. overzealous host immune responses are viewed as key mediators of the pathogenesis of m. pneumoniae infection. although th17 cells have been identified as key modulators in the clearance of pathogens and induction of autoimmunity caused by excessive immune responses, little is known about the role of th17 cells in patients with m. pneumoniae in ...201627240139
increased prevalence of mycoplasma pneumoniae serological positivity in chilean young children.mycoplasma pneumoniae is a frequent cause of respiratory infections in school children and adolescents. epidemiological suspicion is important, since there are no specific symptoms or signs to help in diagnosing infection caused by this agent.201727240442
epidemiology of mycoplasma pneumoniae infections in japan and therapeutic strategies for macrolide-resistant m. pneumoniae.pneumonia caused by mycoplasma pneumoniae (m. pneumoniae pneumonia) is a major cause of community-acquired pneumonia worldwide. the surveillance of m. pneumoniae pneumonia is important for etiological and epidemiological studies of acute respiratory infections. in japan, nation-wide surveillance of m. pneumoniae pneumonia has been conducted as a part of the national epidemiological surveillance of infectious diseases (nesid) program. this surveillance started in 1981, and significant increases i ...201627242718
correlation between radiological and pathological findings in patients with mycoplasma pneumoniae pneumonia.studies focused on the pathological-radiological correlation of human mycoplasma (m) pneumoniae pneumonia have rarely been reported. therefore, we extensively reviewed the literature regarding pathological and radiological studies of mycoplasma pneumonia, and compared findings between open lung biopsy specimen and computed tomography (ct). major three correlations were summarized. (1) peribronchial and perivascular cuffing characterized by mononuclear cells infiltration was correlated with bronc ...201627242720
coinfections with influenza virus and atypical bacteria: implications for severe outcomes? 201627249224
no detection of macrolide-resistant mycoplasma pneumoniae from swedish patients, 1996-2013.mycoplasma pneumoniae is a common cause of respiratory infections which can cause life-threatening pneumonia and serious extrapulmonary manifestations. since the year 2000, the emergence of macrolide-resistant m. pneumoniae strains has increased with varying incidences across countries. in china more than 90% of the strains are resistant. m. pneumoniae diagnostics is mostly done with molecular methods, and in sweden antibiotic resistance surveillance is not routinely performed. the prevalence of ...201627258207
[skin necrosis with vitamin k antagonists: an imbalance between coagulant and anticoagulant factors].skin necrosis with vitamin k antagonists are rare. they affect more frequently middle-aged and obese women, often within 10 days after initiating of treatment. they occur most often in a context of thrombophilia.201727263119
epidemiology of community-acquired pneumonia and implications for vaccination of children living in developing and newly industrialized countries: a systematic literature review.this systematic review evaluated the epidemiology of community-acquired pneumonia in children <6 y of age within 90 developing and newly industrialized countries. literature searches (1990-2011), based on medline, embase, cochrane, cab global health, who, unicef, country-specific websites, conferences, health-technology-assessment agencies, and the reference lists of included studies, yielded 8,734 records; 62 of 340 studies were included in this review. the highest incidence rate among included ...201627269963
community-acquired pneumonia related to intracellular pathogens.community-acquired pneumonia (cap) is associated with high rates of morbidity and mortality worldwide; the annual incidence of cap among adults in europe has ranged from 1.5 to 1.7 per 1000 population. intracellular bacteria are common causes of cap. however, there is considerable variation in the reported incidence between countries and change over time. the intracellular pathogens that are well established as causes of pneumonia are legionella pneumophila, mycoplasma pneumoniae, chlamydophila ...201627276986
bilateral iliac and popliteal arterial thrombosis in a child with focal segmental glomerulosclerosis.thromboembolic complications (tecs) are clinically important sequelae of nephrotic syndrome (ns). the incidence of tecs in children is approximately 2%-5%. the veins are the most commonly affected sites, particularly the deep veins in the legs, the inferior vena cava, the superior vena cava, and the renal veins. arterial thrombosis, which is less common, typically occurs in the cerebral, pulmonary, and femoral arteries, and is associated with the use of steroids and diuretics. popliteal artery t ...201627279890
mycoplasma pneumoniae and streptococcus pneumoniae caused different microbial structure and correlation network in lung microbiota.pneumonia is one of the most serious diseases for children, with which lung microbiota are proved to be associated. we performed 16s rdna analysis on broncho-alveolar lavage fluid (balf) for 32 children with tracheomalacia (c group), pneumonia infected with streptococcus pneumoniae (s. pneumoniae) (d1 group) or mycoplasma pneumoniae (m. pneumoniae) (d2 group). children with tracheomalacia held lower microbial diversity and accumulated lactococcus (mean ± sd, 45.21%±5.07%, p value <0.05), porphyr ...201627293852
etiology of parapneumonic effusion and pleural empyema in children. the role of conventional and molecular microbiological tests.an increasing incidence of parapneumonic effusion and pleural empyema (ppe/pe) has been reported in recent studies. as only few data on etiology of ppe/pe in central europe have been reported, we undertook a study on the etiology of ppe/pe in children, using both standard culture and molecular techniques.201627296817
increased rates of intensive care unit admission in patients with mycoplasma pneumoniae: a retrospective study.mycoplasma pneumoniae is a leading cause of respiratory disease. in the intensive care unit (icu) setting m. pneumoniae is not considered a common pathogen. in 2010-13 an epidemic of m. pneumoniae-associated infections was reported and we observed an increase of m. pneumoniae patients admitted to icu. we analysed the cohort of all m. pneumoniae-positive patients' admissions during 2007 to 2012 at the hadassah-hebrew university medical centre (a 1100-bed tertiary medical centre). mycoplasma pneum ...201627297319
neurological manifestations of mycoplasma pneumoniae infection in hospitalized children and their long-term follow-up.objective in this retrospective study, we aimed to assess frequency, types, and long-term outcome of neurological disease during acute mycoplasma pneumoniae (m. pneumoniae) infection in pediatric patients. materials and methods medical records of patients hospitalized with acute m. pneumoniae infection were reviewed. possible risk factors were analyzed by uni- and multivariate regression. patients with neurological symptoms were followed up by expanded disability status score (edss) and the cogn ...201627299367
clinical features of severe or fatal mycoplasma pneumoniae pneumonia.mycoplasma pneumoniae is one of the most common causes of community-acquired pneumonia in children and young adults. the incidence of fulminant m. pneumoniae pneumonia (mpp) is relatively rare despite the high prevalence of m. pneumoniae infection. this literature review highlights the clinical features of fulminant mpp by examining the most recent data in epidemiology, clinical presentation, pathogenesis, and treatment. fulminant mpp accounts for 0.5-2% of all mpp cases and primarily affects yo ...201627313568
atypical aetiology in patients hospitalised with community-acquired pneumonia is associated with age, gender and season; a data-analysis on four dutch cohorts.microorganisms causing community-acquired pneumonia (cap) can be categorised into viral, typical and atypical (legionella species, coxiella burnetii, mycoplasma pneumoniae, and chlamydia species). extensive microbiological testing to identify the causative microorganism is not standardly recommended, and empiric treatment does not always cover atypical pathogens. in order to optimize epidemiologic knowledge of cap and to improve empiric antibiotic choice, we investigated whether atypical microor ...201627317257
the epidemiology and clinical features of mycoplasma pneumoniae infection in neonates.this retrospective study was aimed to explore the epidemiological and clinical profiles of mycoplasma pneumoniae infection in neonates.201727320858
structural study of mpn387, an essential protein for gliding motility of a human-pathogenic bacterium, mycoplasma pneumoniae.mycoplasma pneumoniae is a human pathogen that glides on host cell surfaces with repeated catch and release of sialylated oligosaccharides. at a pole, this organism forms a protrusion called the attachment organelle, which is composed of surface structures, including p1 adhesin and the internal core structure. the core structure can be divided into three parts, the terminal button, paired plates, and bowl complex, aligned in that order from the front end of the protrusion. to elucidate the glidi ...201627325681
identification of pathogens by comprehensive real-time pcr versus conventional methods in community-acquired pneumonia in japanese adults.community-acquired pneumonia (cap) has high morbidity and mortality. unfortunately, the pathogen detection rate using conventional culture methods is relatively low. we compared comprehensive real-time polymerase chain reaction (real-time pcr) analysis of nasopharyngeal swab specimens (nps) and sputum samples against conventional methods for ability to detect causative pathogens of cap.201727329337
prevalence of pulmonary infections caused by atypical pathogens in non-hiv immunocompromised patients.although atypical bacteria are important causes of lower airway infections, data on their role in immunocompromised patients are scarce. the aim of the study was to evaluate the prevalence of atypical pulmonary infections in patients with various types of immunosuppression, and to analyze clinical characteristics of these infections. eighty non-hiv immunocompromised patients with different underlying diseases and clinical and radiological signs of pulmonary infection were enrolled. due to incomp ...201627334731
mycoplasma pneumoniae infection: risk factor for childhood stroke. 201527335969
directed binding of gliding bacterium, mycoplasma mobile, shown by detachment force and bond lifetime.mycoplasma mobile, a fish-pathogenic bacterium, features a protrusion that enables it to glide smoothly on solid surfaces at a velocity of up to 4.5 µm s(-1) in the direction of the protrusion. m. mobile glides by a repeated catch-pull-release of sialylated oligosaccharides fixed on a solid surface by hundreds of 50-nm flexible "legs" sticking out from the protrusion. this gliding mechanism may be explained by a possible directed binding of each leg with sialylated oligosaccharides, by which the ...201627353751
role of anti-inflammatory cytokines in pathogenesis of pediatric mycoplasma pneumoniae pneumonia.through detection and analysis of the changes of interleukin (il)-2 and il-10 in children with mycoplasma pneumoniae pneumonia (mpp), this study aimed to explore the role of cytokines in the pathogenesis of pediatric mpp as well as immunological pathogenesis of mpp, to provide guidance for clinical diagnosis, assessment and treatment of mpp. enzyme linked immunosorbent adsorption (elisa) analysis was applied to determine the expression level of il-2 and il-10 in serum. according to the experimen ...201627358146
underdiagnosing of mycoplasma pneumoniae infections as revealed by use of a respiratory multiplex pcr panel.we compared a multiplex pcr diagnostic approach against specific pcr diagnosis for detection of mycoplasma pneumoniae infection. seventy-five percent of all m. pneumoniae infections were only detected "unintentionally" by the use of the multiplex pcr indicating underdiagnosing of m. pneumoniae due to absence of clinical suspicion.201627377674
community-acquired pneumonia caused by mycoplasma pneumoniae: how physical and radiological examination contribute to successful diagnosis.mycoplasma pneumoniae is one of the most common causes of community-acquired pneumonia (cap), particularly in young adults. vital signs are usually normal except for temperature. on physical examination, general appearance is normal compared with that of typical pneumonia such as pneumococcal pneumonia patients. mycoplasma sometimes causes ear infections such as otitis media. it is important to distinguish between typical pneumonia and atypical pneumonia such as mycoplasma pneumonia because havi ...201627379238
chronic infection and severe asthma.chronic bacterial infection is implicated in both the development and severity of asthma. the atypical bacteria mycoplasma pneumoniae and chlamydophila pneumoniae have been identified in the airways of asthmatics and correlated with clinical features such as adult onset, exacerbation risks, steroid sensitivity, and symptom control. asthmatic patients with evidence of bacterial infection may benefit from antibiotic treatment directed towards these atypical organisms. examination of the airway mic ...201627401621
[distribution characteristics of mycoplasma pneumoniae, chlamydia pneumoniae, and legionella pneumophila in hospitalized children with acute respiratory tract infection: an analysis of 13 198 cases].to investigate the distribution characteristics of mycoplasma pneumoniae (mp), chlamydia pneumoniae (cp), and legionella pneumophila (lp) in hospitalized children with acute respiratory tract infection (arti).201627412543
[bronchitis obliterans associated with bronchiolitis obliterans with organizing pneumonia in a child and literature review].to investigate the clinical-radiologic-pathologic features of bronchitis obliterans that complicated with bronchiolitis obliterans with organizing pneumonia (boop).201627412744
[community acquired pneumonia - treatment options according to the international recommendations].pneumonia remains one of the main reasons of heath care system utilization. quick diagnosis and prompt treatment initiation determine favorable outcome. empirical antibiotic treatment allows to achieve treatment success in most patients. treatment recommendations are based on big epidemiological trials. nevertheless, it is sometimes necessary to know the definite etiologic factor of pneumonia. in these cases microbiological diagnostics is useful, i.e. sputum microscopy and culture, blood culture ...201627421128
effects of traditional chinese medicine qinbai qingfei concentrated pellet on cellular infectivity of mycoplasma pneumoniae.aim. to study the effect and mechanism of traditional chinese medicine qinbai qingfei concentrated pellet (qqcp) against mycoplasma pneumoniae (mp). methods. rat airway smooth muscle (asm) cells were used to examine the antimycoplasmal activity of qqcp via four drug-adding modes: pre- and postadding drugs, simultaneous-adding after drug and mp mixed, and simultaneous-adding drug and mp; taking roxithromycin dispersive tablets (rdt) as positive control, the cellular a 570 values were determined b ...201427433528
mycoplasmal pneumonia.preview mycoplasmal pneumonia can present with a variety of clinical and laboratory findings. diagnosis may be complicated by an atypical presentation and by extrapulmonary manifestations, which occur in about one third of patients. drs stogner and anderson provide valuable insights into recognition and treatment of this common atypical pneumonia in their discussion of two cases that illustrate the varied aspects of infection with mycoplasma pneumoniae.199027434069
measurement of lipocalin-2 and syndecan-4 levels to differentiate bacterial from viral infection in children with community-acquired pneumonia.in this study, we evaluated the lipocalin-2 (lip2) and syndecan-4 (syn4) levels in children who were hospitalized for radiologically confirmed cap in order to differentiate bacterial from viral infection. the results regarding the lip2 and syn4 diagnostic outcomes were compared with the white blood cell (wbc) count and c reactive protein (crp) levels.201627439403
integrated information and prospects for gliding mechanism of the pathogenic bacterium mycoplasma pneumoniae.mycoplasma pneumoniae forms a membrane protrusion at a cell pole and is known to adhere to solid surfaces, including animal cells, and can glide on these surfaces with a speed up to 1 μm per second. notably, gliding appears to be involved in the infectious process in addition to providing the bacteria with a means of escaping the host's immune systems. however, the genome of m. pneumoniae does not encode any of the known genes found in other bacterial motility systems or any conventional motor p ...201627446003
mycoplasma pneumoniae: current knowledge on macrolide resistance and treatment.mycoplasma pneumoniae causes community-acquired respiratory tract infections, particularly in school-aged children and young adults. these infections occur both endemically and epidemically worldwide. m. pneumoniae lacks cell wall and is subsequently resistant to beta-lactams and to all antimicrobials targeting the cell wall. this mycoplasma is intrinsically susceptible to macrolides and related antibiotics, to tetracyclines and to fluoroquinolones. macrolides and related antibiotics are the fir ...201627446015
isolation of chlamydia abortus from a laboratory worker diagnosed with atypical pneumonia.identifying the aetiological agent of atypical pneumonia in human can sometimes be a tedious process, especially in cases where mycoplasma pneumoniae, legionella species and chlamydia pneumoniae are ruled out. in such cases, a correct anamnesis of the patient is basic to clarify which pathogens might have produced the infection. for this reason, health professionals including veterinarians and laboratory personnel working with zoonotic pathogens should keep their doctors informed.201527446530
viral etiology in adult influenza-like illness/acute respiratory infection and predictivity of c-reactive protein.influenza-like illness (ili) and acute respiratory infection (ari) are common presentations during winter and indiscriminate antibiotic use contributes significantly to the emerging post-antibiotic era.201627482806
mycoplasma pneumoniae triggering the guillain-barré syndrome: a case-control study.guillain-barré syndrome (gbs) is an acute postinfectious immune-mediated polyneuropathy. although preceding respiratory tract infections with mycoplasma pneumoniae have been reported in some cases, the role of m. pneumoniae in the pathogenesis of gbs remains unclear. we here cultured, for the first time, m. pneumoniae from a gbs patient with antibodies against galactocerebroside (galc), which cross-reacted with the isolate. this case prompted us to unravel the role of m. pneumoniae in gbs in a c ...201627490360
acute pancreatitis and pneumonia due to mycoplasma pneumoniae: a case report.mycoplasma pneumoniae is a bacterium responsible for 15 to 40 % of acute community-acquired pneumonia in children and 20 % of adult cases. several extrapulmonary manifestations have been reported. we report a rare case of an adult patient suffering from pneumonia associated with an acute pancreatitis in the setting of mycoplasma pneumoniae infection.201627506562
changes in the levels of interleukin-17 between atopic and non-atopic children with mycoplasma pneumoniae pneumonia.as previous study showed that mycoplasma pneumoniae (mp) induced a cellular immune response associated with interleukin-17 (il-17), we designed this study to explore il-17 in mp pneumonia patients with atopic sensitization and 144 patients were evaluated and divided into three groups: atopic mp pneumonia group (n = 38), non-atopic mp pneumonia group (n = 74), and atopic non-mp pneumonia group (n = 32). serum il-17 was measured at admission acute phase and at recovery phase. we found il-17 levels ...201627531365
characterization and evaluation of a novel immunochromatographic assay for pharyngeal mycoplasmapneumoniae ribosomal protein l7/l12 antigens.point-of-care testing for mycoplasma pneumoniae infection may be ideal and useful because significant numbers of the cases will be seen as outpatients. recently, a new immunochromatographic method (icm) targeting m. pneumoniae ribosomal protein l7/l12 (rp-l7/l12) in pharyngeal swabs became available in japan, although clinical data and basic information regarding efficacy and characterization of this icm are limited. the present study examined the fate of m. pneumoniae rp-l7/l12 during in vitro ...201627542383
refractory wheezing in chinese children under 3 years of age: bronchial inflammation and airway malformation.wheezing is a common symptom in early childhood. however, refractory wheezing is difficult to treat, and it may thus account for extensive use of medical resources. it is therefore important to improve our understanding of the pathophysiology of refractory childhood wheezing.201627568177
alice in wonderland syndrome associated with mycoplasma infection.alice in wonderland syndrome (aiws) is a rare condition in which patients report distorted size perception of objects and their own bodies. although specific causes and pathology have not been elucidated, an association between aiws and infection has been suggested. to our knowledge, mycoplasma-induced aiws has not been examined. a girl aged 7 years 11 months presented with fever (temperature, 40°c) and cough. although the fever disappeared after approximately 10 days, she complained that her mo ...201627577175
prevalence of macrolide-resistant mycoplasma pneumoniae in south australia. 201627596238
mpn491, a secreted nuclease of mycoplasma pneumoniae, plays a critical role in evading killing by neutrophil extracellular traps.neutrophils play an important role in antimicrobial defense as the first line of innate immune system. recently, the release of neutrophil extracellular traps (nets) has been identified as a killing mechanism of neutrophils against invading microbes. mycoplasma pneumoniae, a causative agent of respiratory infection, has been shown to be resistant to in vitro killing by neutrophils, suggesting that the bacterium might circumvent bactericidal activity of nets. in this study, we investigated whethe ...201727603754
plasmodium falciparum and mycoplasma pneumoniae co-infection presenting with cerebral malaria manifesting orofacial dyskinesia and haemophagocytic lymphohistiocytosis.malaria is a mosquito-borne infectious disease with diverse clinical manifestations caused by a parasitic protozoan of the genus plasmodium. complex inter-relationships between mycoplasma species and plasmodium parasites have been previously noted in vitro. this is the first report of plasmodium falciparum and mycoplasma pneumoniae co-infection in a human host presenting with cerebral malaria manifesting orofacial dyskinesias and haemophagocytic lymphohistiocytosis.201627609213
kawasaki disease associated with mycoplasma pneumoniae.kawasaki disease (kd) is an illness of unknown etiology that mostly occurs in children under 5 years of age and is the leading cause of acquired heart disease all over the world. mycoplasma pneumoniae (mp) was one of the likely causative agents of kd. however, the etiologic effect of mp in kd has not been fully recognized.201627609267
interactions of surface-displayed glycolytic enzymes of mycoplasma pneumoniae with components of the human extracellular matrix.mycoplasma pneumoniae is a major cause of community-acquired respiratory infections worldwide. due to the strongly reduced genome, the number of virulence factors expressed by this cell wall-less pathogen is limited. to further understand the processes during host colonization, we investigated the interactions of the previously confirmed surface-located glycolytic enzymes of m. pneumoniae (pyruvate dehydrogenase a-c [pdha-c], glyceraldehyde-3-phosphate dehydrogenase [gapa], lactate dehydrogenase ...201627616280
mycoplasma pneumonia-associated choroidal neovascularization-bevacizumab intravitreal injection and laser treatment.to report a rare case of bilateral subretinal granulomas with choroidal neovascularization after mycoplasma pneumoniae atypical pneumonia.201627648584
two case reports: whole genome sequencing of two clinical macrolide-resistant mycoplasma pneumoniae isolates with different responses to azithromycin.cases of macrolide-resistant mycoplasma pneumoniae have increased rapidly since 2000, especially in asia. patients infected with macrolide-resistant m pneumoniae usually present with severe m pneumoniae pneumonia. the aim of this study was to identify indicators for whether children at an early stage of m pneumoniae infection develop mild or severe pneumonia.201627661056
[childhood postinfectious erythema multiforme].postinfectious erythema multiforme is an uncommon skin disease in childhood that can have a strong impact, especially in infants if there is involvement of the mucous membranes. the lesion is targeted (central bullous lesions with three concentric circles). its diagnosis is typically made clinically. atypical forms are the highly inflammatory, mainly bullous type, with exclusive involvement of the mucous membrane, or recurrent erythema multiforme. the diagnosis of erythema multiforme is frequent ...201627663464
insights into the pathogenesis of mycoplasma pneumoniae (review).mycoplasma are the smallest prokaryotic microbes present in nature. these wall‑less, malleable organisms can pass through cell filters, and grow and propagate under cell‑free conditions in vitro. of the pathogenic mycoplasma mycoplasma pneumoniae has been examined the most. in addition to primary atypical pneumonia and community‑acquired pneumonia with predominantly respiratory symptoms, m. pneumoniae can also induce autoimmune hemolytic anemia and other diseases in the blood, cardiovascular sys ...201627667580
in vitro activities of omadacycline (ptk 0796) and other antimicrobial agents against human mycoplasmas and ureaplasmas.in vitro activities of omadacycline, a new aminomethylcycline, were determined for mycoplasma and ureaplasma spp. and compared with those of azithromycin, clindamycin, moxifloxacin, tetracycline, and doxycycline. all omadacycline mics were <2 μg/ml. mic90s were 0.063 μg/ml for mycoplasma hominis, 0.25 μg/ml for mycoplasma pneumoniae, and 2 μg/ml for ureaplasma spp. omadacycline had the lowest mic90 among all drugs tested against m. hominis omadacycline activity was not affected by macrolide, tet ...201627671057
prediction of bronchial mucus plugs formation in patients with refractory mycoplasma pneumoniae pneumonia.we aimed to find the relationship between the clinical characteristics and mucus plug formation and developed models to predict mucus plug formation in refractory mycoplasma pneumoniae pneumonia (rmpp) infection.201627686558
to study the association between anti-chlamydia pneumoniae antibodies (igg), anti-mycoplasma pneumoniae antibodies (igg) and coronary artery disease (cad). 201627727592
association between infectious burden, socioeconomic status, and ischemic stroke.infectious diseases contribute to stroke risk, and are associated with socioeconomic status (ses). we tested the hypotheses that the aggregate burden of infections increases the risk of ischemic stroke (is) and partly explains the association between low ses and ischemic stroke.201627728851
inter- and intra-strain variability of tandem repeats in mycoplasma pneumoniae based on next-generation sequencing data.to characterize inter- and intra-strain variability of variable-number tandem repeats (vntrs) in mycoplasma pneumoniae to determine the optimal multilocus vntr analysis scheme for improved strain typing.201727728978
[application of mycoplasma pneumoniae antibody and load index in the diagnosis of mycoplasma pneumoniae pneumonia in children].to study the role of mycoplasma pneumoniae (mp) load and antibody measurements in the diagnosis of mp pneumonia.201627751216
community-acquired pneumonia in the post 13-valent pneumococcal conjugate vaccine era.this review covers the outpatient management of pediatric community-acquired pneumonia (cap), discussing the changing microbiology of cap since the introduction of the 13-valent pneumococcal conjugate vaccine in 2010, and providing an overview of national guideline recommendations for diagnostic evaluation and treatment.201627755118
role of serum mycoplasma pneumoniae iga, igm, and igg in the diagnosis of mycoplasma pneumoniae-related pneumonia in school-age children and adolescents.mycoplasma pneumoniae is an important causative pathogen of community-acquired pneumonia in children. rapid and reliable laboratory diagnosis of m. pneumoniae infection is important so that appropriate antibiotic treatment can be initiated to reduce the misuse of drugs and resistance rates. anti-m. pneumoniae immunoglobulin m (igm) is an indicator of recent primary infection but can persist for several months after initial infection. it has been suggested that anti-m. pneumoniae immunoglobulin a ...201727760779
microbial etiology of community-acquired pneumonia among infants and children admitted to the pediatric hospital, ain shams university.while recognizing the etiology of community-acquired pneumonia is necessary for formulating local antimicrobial guidelines, limited data is published about this etiology in egyptian pediatric patients.201627766169
bacterial co-infection in hospitalized children with mycoplasma pneumoniae pneumonia.to describe the frequency and impact of bacterial co-infections in children hospitalized with mycoplasma pneumoniae pneumonia.201627771667
respiratory microbes present in the nasopharynx of children hospitalised with suspected pulmonary tuberculosis in cape town, south africa.lower respiratory tract infection in children is increasingly thought to be polymicrobial in origin. children with symptoms suggestive of pulmonary tuberculosis (ptb) may have tuberculosis, other respiratory tract infections or co-infection with mycobacterium tuberculosis and other pathogens. we aimed to identify the presence of potential respiratory pathogens in nasopharyngeal (np) samples from children with suspected ptb.201627776489
predicting the presence of bacterial pathogens in the airways of primary care patients with acute cough.bacterial testing of all patients who present with acute cough is not feasible in primary care. furthermore, the extent to which easily obtainable clinical information predicts bacterial infection is unknown. we evaluated the diagnostic value of clinical examination and testing for c-reactive protein and procalcitonin for bacterial lower respiratory tract infection.201727777252
cortical blindness in a child secondary to mycoplasma pneumoniae infection.our objective is to present a case of an uncommon complication associated with mycoplasma pneumoniae infection in a child where cortical blindness was the main clinical feature. stroke due to an infection by m. pneumoniae is very uncommon. no consensus has been reached on the pathogenesis, although several pathogenic mechanisms have been proposed. occlusion of posterior cerebral circulation is the most uncommon central nervous system complication of m. pneumoniae infection being reported. sympto ...201727789154
development of an endpoint genotyping assay to detect the mycoplasma pneumoniae 23s rrna gene and distinguish the existence of macrolide resistance-associated mutations at position 2063.the prevalence of macrolide-resistant mycoplasma pneumoniae harboring a mutation in the 23s rrna gene is increasing, and rapid detection assays are needed for clinical management. we developed an endpoint genotyping assay to detect the m. pneumoniae 23s rrna gene and determine the existence of macrolide resistance-associated mutations at position 2063 (a2063g, a2063t and a2063c mutations). this a2063b genotyping assay detected more than 50 copies/reaction of the m. pneumoniae gene in every nucle ...201627789313
infectious burden and semen parameters.to investigate the relationship between chronic infections detected in serum and semen quality. the pathogen burden is a concept consisting in the observation that, in patients with heart disease, damaging effects of the coronary arteries increase concomitantly with the number of agents responsible for chronic infections to which patients mounted a serological response. previous observations that helicobacter pylori infection may reduce the semen quality prompted us to perform the present study.201727793655
prevalence and seasonal distribution of respiratory viruses during the 2014 - 2015 season in istanbul.acute respiratory tract infection (arti) is one of the most common infections worldwide, causing significant morbidity and mortality.201627800148
role of atypical bacteria in hospitalized patients with nursing home-acquired pneumonia.background: nursing home-acquired pneumonia (nhap) has been identified as one of the leading causes of mortality and hospitalization for long-term care residents. however, current and previous pneumonia guidelines differ on the appropriate management of nhap in hospitalized patients, specifically in regard to the role of atypical bacteria such as chlamydiae pneumonia, mycoplasma pneumoniae, and legionella. objectives: the purpose of this review is to evaluate clinical trials conducted in hospita ...201627803507
[association between wheezing and mycoplasma pneumoniae infection in infants and young children].to study the association between wheezing and mycoplasma pneumoniae (mp) infection in infants and young children.201627817771
cytokines as the good predictors of refractory mycoplasma pneumoniae pneumonia in school-aged children.excessive immune response against pathogens may play an important role in refracory mycoplasma pneumoniae pneumonia (rmpp). the aim of this study was to elucidate the associations between cytokines and the prediction of rmpp in school-aged patients. retrospective analysis was performed on school-aged children with mycoplasma pneumoniae pneumonia (mpp) hospitalized in our hospital between january 1, 2011 and december 31, 2015. the clinical charcteristics, including the cytokines in serum between ...201627833154
comparison of mycoplasma pneumoniae genome sequences from strains isolated from symptomatic and asymptomatic patients.mycoplasma pneumoniae is a common cause of respiratory tract infections (rtis) in children. we recently demonstrated that this bacterium can be carried asymptomatically in the respiratory tract of children. to identify potential genetic differences between m. pneumoniae strains that are carried asymptomatically and those that cause symptomatic infections, we performed whole-genome sequence analysis of 20 m. pneumoniae strains. the analyzed strains included 3 reference strains, 3 strains isolated ...201627833597
mycoplasma pneumoniae-associated mild encephalitis/encephalopathy with a reversible splenial lesion: report of two pediatric cases and a comprehensive literature review.no literature review exists on mycoplasma pneumoniae-associated mild encephalitis/encepharopathy with a reversible splenial lesion (mers).201627836006
adult onset still's disease associated with mycoplasma pneumoniae infection and hemophagocytic lymphohistiocytosis.adult onset still's disease (aosd) is a systemic inflammatory disorder that can be associated with hemophagocytic lymphohistiocytosis (hlh), a rare but potentially fatal disease of overactive histiocytes and lymphocytes. we present a unique case of aosd complicated by mycoplasma pneumonia infection and hlh. a 28-year-old female developed joint pains followed by a diffuse, erythematous, pruritic skin rash that quickly spread throughout the body. the patient deteriorated and developed fever, chill ...201627847518
in vitro activities of lefamulin and other antimicrobial agents against macrolide-susceptible and macrolide-resistant mycoplasma pneumoniae from the united states, europe, and china.lefamulin, an investigational pleuromutilin, was tested against a collection of 18 macrolide-susceptible and 42 macrolide-resistant mycoplasma pneumoniae strains, and the results were compared with those of azithromycin, erythromycin, tetracycline, doxycycline, and moxifloxacin testing. lefamulin was highly active against all strains tested, with all mics at ≤0.008 μg/ml. the lefamulin mic90 (0.002 μg/ml) for macrolide-resistant strains was the lowest among all drugs tested. minimum bactericidal ...201727855075
Refresh
firstprev
...51525354555657
nextlast
Displaying items 5401 - 5500 of 5647