Publications
| Title | Abstract | Year Filter | PMID(sorted ascending) Filter |
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| the structure and biological aspects of peptide antibiotic microcin j25. | microcin j25 (mccj25) is a plasmid-encoded peptide of 21 l-amino acids (g1-g-a-g-h5-v-p-e-y-f10-v-g-i-g-t15-p-i-s-f-y20-g), excreted to the medium by an escherichia coli strain. mccj25 is active on gram-negative bacteria related to the producer strain, including some pathogenic strains. the four-plasmid genes mcjabcd, are involved in mccj25 production: mcja encodes a 58-residue precursor, mcjb and mcjc codify two processing enzymes required for the in vivo synthesis of the mature peptide and mcj ... | 2009 | 19199920 |
| molecular characterization of antimicrobial resistance in salmonella isolated from animals in japan. | aims: to investigate the prevalence of integrons and antimicrobial resistance genes in salmonella recovered from animals in japan. methods and results: forty-eight out of ninety-four (51.1%) salmonella isolates showed multidrug resistance phenotypes and harboured at least one antimicrobial resistance gene. twenty-two out of forty-seven (46.8%) salmonella enterica serovar typhimurium that were multidrug-resistant were of definitive phage type dt104. class 1 integrons were identified in 34/94 isol ... | 2009 | 19200308 |
| distribution and genotypic characterization of salmonella serovars isolated from tropical seafood of cochin, india. | to determine the distribution of salmonella serovars in seafood and to examine the intraserovar genetic variations in salmonella enterica subsp. enterica serovar rissen and salmonella weltevreden by polymerase chain reaction (pcr)-ribotyping and enterobacterial repetitive intergenic consensus (eric)-pcr methods. | 2009 | 19200318 |
| expression of porcine toll-like receptor 2, 4 and 9 gene transcripts in the presence of lipopolysaccharide and salmonella enterica serovars typhimurium and choleraesuis. | salmonella enterica serovar typhimurium (st) and choleraesuis (sc) are among the most frequently isolated salmonellae serovars causing enteric disease in swine. enteric disease in young pigs is of major concern in modern production systems due to the negative implications on animal health, food safety and economic return. epithelial cells express toll-like receptors (tlr) that recognize conserved microbial structures and act as mediators of innate and adaptive immune responses. however, little i ... | 2009 | 19200608 |
| methods to monitor autophagy of salmonella enterica serovar typhimurium. | autophagy is an important component of the mammalian innate immune system and is able to specifically target intracellular bacterial pathogens. salmonella enterica serovar typhimurium is an intracellular pathogen that causes gastroenteritis in humans. autophagy has been shown to target s. typhimurium during in vitro infection of mammalian cultured cells and protects the cytosol of these cells from bacterial colonization. here we discuss autophagic sequestration of s. typhimurium and how it can b ... | 2009 | 19200891 |
| expression profile of toll-like receptors within the gastrointestinal tract of 2-day-old salmonella enteriditis-infected broiler chickens. | salmonella enterica serovar enteriditis (se) causes a majority of foodborne illness in the u.s. a more productive avian innate immune response could reduce bacterial colonization and the incidence of infection in humans. however, quantification and comparison of the toll-like receptors (tlr), a component of the innate immune system that recognize bacterial pathogens, and their response to se colonization across the avian gastrointestinal (gi) tract has not been reported. therefore, we assessed t ... | 2009 | 19201111 |
| distribution of mutation frequencies among salmonella enterica isolates from animal and human sources and genetic characterization of a salmonella heidelberg hypermutator. | hypermutation is an important mechanism used by different salmonella enterica subspecies enterica to regulate genetic stability in adaptation to changing environments, including antimicrobial treatments and industrial processes. strong hypermutator strains generally contain a mutation in genes of the methyl mismatch repair (mmr) system and have mutation frequencies up to 1000-fold higher than wild type strains. the objectives of this study were to determine the distribution of mutation frequenci ... | 2009 | 19201550 |
| a conserved alpha-helix essential for a type vi secretion-like system of francisella tularensis. | francisella tularensis harbors genes with similarity to genes encoding components of a type vi secretion system (t6ss) recently identified in several gram-negative bacteria. these genes include igla and iglb encoding igla and iglb, homologues of which are conserved in most t6sss. we used a yeast two-hybrid system to study the interaction of the igl proteins of f. tularensis lvs. we identified a region of igla, encompassing residues 33 to 132, necessary for efficient binding to iglb, as well as f ... | 2009 | 19201795 |
| innate immunity mediated by myd88 signal is not essential for induction of lipopolysaccharide-specific b cell responses but is indispensable for protection against salmonella enterica serovar typhimurium infection. | salmonella organisms are gram negative and facultative anaerobic bacteria that cause typhoid fever in humans. in this study, we evaluated lps-specific adaptive immunity in innate immune-deficient mice after oral administration of attenuated salmonella enterica serovar typhimurium (s. typhimurium) strains. of interest, identical levels of lps-specific igg and iga abs were elicited in the systemic (i.e., serum and spleen) and mucosal (i.e., fecal extract and small intestine) compartments of wild-t ... | 2009 | 19201885 |
| prevalence and characterization of salmonellae in commercial ground beef in the united states. | commercially produced ground beef samples (n = 4,136) were collected from seven regions of the united states over a 24-month period (july 2005 to june 2007) and analyzed for the presence of salmonella enterica by using methods that concurrently provided total prevalence and enumerable levels. the overall prevalence of salmonella strains was 4.2%. enumeration showed that 94.2% were present at levels below 2 cfu/g. regional monthly prevalences of salmonella strains varied from 1.8% to 6.5% but wer ... | 2009 | 19201965 |
| gfp plasmid-induced defects in salmonella invasion depend on plasmid architecture, not protein expression. | we have investigated the impact of plasmids and gfp expression on invasion of cultured epithelial cells by salmonella enterica typhimurium strain sl1344. the invasiveness of sl1344 carrying plasmids derived from pbr322, encoding promoterless gfp or constitutively expressed rpsm-gfp, was compared under optimal growth conditions with that of sl1344(pbr322), unmodified sl1344 and a strain with chromosome-integrated rpsm-gfp. the strain carrying pbr322 exhibited normal invasion, but the presence of ... | 2009 | 19202094 |
| surface display of the receptor-binding domain of the f17a-g fimbrial adhesin through the autotransporter aida-i leads to permeability of bacterial cells. | surface exposure of antigens on bacterial cells can be critical for eliciting an effective antibody response. therefore, we investigated the cellular localization of the fimbrial f17a-g receptor-binding domain, fused to the translocator domain of the aida-i autotransporter. synthesis of the fusion protein, under the control of the l-arabinose-inducible pbad promoter, was shown to permeabilize escherichia coli k-12 and salmonella enterica serovar typhimurium cells. the presence of permeable cells ... | 2009 | 19202095 |
| a novel phop-regulated locus encoding the cytolysin clya and the secreted invasin taia of salmonella enterica serovar typhi is involved in virulence. | salmonella enterica serovar typhi causes a human-restricted systemic infection called typhoid fever. we have identified a typhi genomic region encoding two orfs, sty1498 and sty1499, that are expressed during infection of human macrophages and organized in an operon. sty1498 corresponds to clya, which encodes a pore-forming cytolysin, and sty1499 encodes a 27 kda protein, without any attributed function, which we have named taia (typhi-associated invasin a). in order to evaluate the roles of the ... | 2009 | 19202096 |
| effects of mesalamine (5-aminosalicylic acid) on bacterial gene expression. | 5-aminosalicylic acid (5-asa) is a well-established treatment for inflammatory bowel disease (ibd) and may reduce the risk of colon cancer in patients with chronic colitis, but the mechanisms underlying these effects have not been fully elucidated. although 5-asa delivery is targeted to the distal gut, little is known about its effects on the luminal bacteria that reside there. intestinal bacteria are believed play a role in causing or perpetuating ibd, and bioremediation has been studied as a t ... | 2009 | 19202572 |
| salmonella administration induces a reduction of wheel-running activity via a tlr5-, but not a tlr4, dependent pathway in mice. | in general, systemic bacterial infections induce sickness behavior. in mice, lipopolysaccharide (lps), a component of gram-negative bacteria, strongly reduces physical activity via toll-like receptor (tlr) 4. however, gram-negative bacteria, such as salmonella, also express flagella containing flagellin (fg) which binds to tlr5 and induces pro-inflammatory cytokine production. it is unclear whether fg induces sickness behavior. to determine whether salmonella administration regulates the reducti ... | 2008 | 19203083 |
| paracoccidioides brasiliensis vaccine formulations based on the gp43-derived p10 sequence and the salmonella enterica flic flagellin. | paracoccidioidomycosis (pcm) is a systemic granulomatous disease caused by the dimorphic fungus paracoccidioides brasiliensis. anti-pcm vaccine formulations based on the secreted fungal cell wall protein (gp43) or the derived p10 sequence containing a cd4(+) t-cell-specific epitope have shown promising results. in the present study, we evaluated new anti-pcm vaccine formulations based on the intranasal administration of p. brasiliensis gp43 or the p10 peptide in combination with the salmonella e ... | 2009 | 19204092 |
| dna recognition by the salmonella enterica serovar typhimurium transcription factor slya. | the salmonella regulatory protein slya is implicated in virulence, survival in macrophages and resistance to oxidative stress and anti-microbial peptides. slya is a member of the marr family of winged-helix transcription factors. systematic mutational analysis of the slya operator sequence and of the predicted dna-binding region of slya shows that no single base pair in the palindromic slya operator sequence is essential for dna binding, and identifies amino acid residues required to allow slya ... | 2008 | 19204896 |
| control of foodborne pathogens and soft-rot bacteria on bell pepper by three strains of bacterial antagonists. | forty-two representative strains of native bacteria associated with fresh peeled baby carrots were isolated and characterized. two of these strains, identified as pseudomonas fluorescens ag3a (pf ag3a) and bacillus yd1, were evaluated in conjunction with another known antagonist, p. fluorescens 2-79 (pf 2-79), for their potential as biocontrol agents of human pathogens (listeria monocytogenes, yersinia enterocolitica, salmonella enterica, and escherichia coli o157:h7) and soft-rot bacteria (erwi ... | 2009 | 19205468 |
| a method for investigating protein-protein interactions related to salmonella typhimurium pathogenesis. | we successfully modified an existing method to investigate protein-protein interactions in the pathogenic bacterium salmonella enterica serovar typhimurium (salmonella typhimurium). this method includes (i) addition of a histidine-biotin-histidine tag to the bait proteins via recombinant dna techniques, (ii) in vivo cross-linking with formaldehyde, (iii) tandem affinity purification of bait proteins under fully denaturing conditions, and (iv) identification of the proteins cross-linked to the ba ... | 2009 | 19206470 |
| pathogen trafficking pathways and host phosphoinositide metabolism. | phosphoinositide (pi) glycerolipids are key regulators of eukaryotic signal transduction, cytoskeleton architecture and membrane dynamics. the host cell pi metabolism is targeted by intracellular bacterial pathogens, which evolved intricate strategies to modulate uptake processes and vesicle trafficking pathways. upon entering eukaryotic host cells, pathogenic bacteria replicate in distinct vacuoles or in the host cytoplasm. vacuolar pathogens manipulate pi levels to mimic or modify membranes of ... | 2009 | 19208094 |
| hydrophobic peptides: novel regulators within bacterial membrane. | identification of short coding sequences is challenging, both experimentally and in silico, and functional natural peptides (< 50 amino acids) have to a large extent been overlooked in gram-negative bacteria. recent results have converged to highlight the role of hydrophobic peptides that form a novel class of active molecules in escherichia coli and salmonella enterica serovar typhimurium. these peptides can play a regulatory role by interacting with protein partners at the inner membrane and b ... | 2009 | 19210615 |
| sequence analysis of escherichia coli o157:h7 bacteriophage phiv10 and identification of a phage-encoded immunity protein that modifies the o157 antigen. | bacteriophage phiv10 is a temperate phage, which specifically infects escherichia coli o157:h7. the nucleotide sequence of the phiv10 genome is 39 104 bp long and contains 55 predicted genes. phiv10 is closely related to two previously sequenced phages, the salmonella enterica serovar anatum (group e1) phage epsilon15 and a prophage from e. coli apec o1. the attachment site of phiv10, like those of its two closest relatives, overlaps the 3' end of guaa in the host chromosome. phiv10 encodes an o ... | 2009 | 19210675 |
| antimicrobial properties of the equine alpha-defensin defa1 against bacterial horse pathogens. | defensins are small effector molecules of the innate immune system, synthesised by various organisms including plants and animals. the peptides act as endogenous antibiotics with an antimicrobial activity against a broad spectrum of microbes including bacteria, fungi and viruses. alpha-defensins are a subgroup of the defensin family, their synthesis is limited to some tissues and furthermore to some mammalian species including the horse. equine defa1 is an enteric alpha-defensin exclusively prod ... | 2009 | 19211153 |
| re-emerging chloramphenicol sensitivity and emerging low level ciprofloxacin resistance among salmonella enterica serotype typhi isolates in north india. | ciprofloxacin has become the antibiotic of choice for the treatment of typhoid fever with the emergence and worldwide spread of salmonella enterica typhi strains resistant to chloramphenicol. however, the rampant use of ciprofloxacin gradually led to an increase in its minimum inhibitory concentration against s. enterica typhi. this threatened its therapeutic efficacy and resulted in the re-emergence of chloramphenicol-sensitive s. enterica typhi strains. | 2009 | 19211419 |
| effect of a direct-fed microbial (primalac) on structure and ultrastructure of small intestine in turkey poults. | the effects of dietary supplementation of the direct-fed microbial (dfm) primalac in mash or crumbled feed on histological and ultrastructural changes of intestinal mucosa was determined in 2 populations of poults; 1 with and 1 without a salmonella spp. challenge. three hundred thirty-six 1-d-old female large white turkey poults were randomly distributed into 8 treatment groups with 6 replicates of 7 poults in each pen. the poults were placed on 1 of 4 dietary treatments in a 2 x 2 x 2 factorial ... | 2009 | 19211517 |
| intestinal mmc-related electric fields and pancreatic juice control the adhesion of gram-positive and gram-negative bacteria to the gut epithelium--in vitro study. | the adhesion of six different lactobacillus and lactococcus and three pathogenic escherichia and salmonella strains was studied using caco-2 cell line. in this in vitro model system the influence of weak electric field (ef) on bacterial adhesion was tested. the ef source was the in vitro reconstruction of spiking potentials recorded in the duodenum of a healthy calf during one myoelectrical migration complex (mmc) cycle. the ability to adhere to caco-2 cells of bacteria belonging to two groups, ... | 2008 | 19212012 |
| construction of highly attenuated salmonella enterica serovar typhimurium live vectors for delivering heterologous antigens by chromosomal integration. | attenuated live salmonella enterica serovar typhimurium is a versatile organism for the generation of live recombinant vaccines for mucosal immunization and various approaches were devised for the stable and efficient expressions of heterologous antigens by attenuated s. enterica strains. phage lamda red recombinase has recently been devised for gene replacements in s. enterica after introduction of pcr products as a one-step deletion approach and flp-mediated recombination allows the subsequent ... | 2008 | 19216101 |
| a comparison of two pcr-based typing methods with pulsed-field gel electrophoresis in salmonella enterica serovar enteritidis. | two novel molecular typing methods, multiple-locus variable-number tandem repeats (vntr) analysis (mlva) and multiple amplification of phage loci typing (maplt), were compared with pulsed-field gel electrophoresis (pfge) for the discrimination of 128 salmonella enterica serovar enteritidis (s. enteritidis) isolates. selected epidemiologically unrelated isolates represented a cross-section of phage types routinely isolated in australia and included 28 isolates that could not be assigned a phage t ... | 2009 | 19217348 |
| [evolutionary engineering in salmonella: emergence of hybrid virulence-resistance plasmids in non-typhoid serotypes]. | an example of evolutive engineering in bacterial pathogens is the emergence of hybrid virulence-resistance (vr) plasmids in salmonella enterica, resulting from an association between antimicrobial resistance determinants and specific virulence plasmids of the s. typhimurium and s. choleraesuis serotypes. vr plasmids all possess the spv (salmonella plasmid virulence) operon, which is involved in systemic infection; however, they differ in the presence of other virulence determinants and in the re ... | 2009 | 19218002 |
| subspecies iiia and iiib salmonellae are defective for colonization of murine models of salmonellosis compared to salmonella enterica subsp. i serovar typhimurium. | non-subspecies i salmonellae are commensals of cold-blooded vertebrates and cause sporadic disease in mammals. the reasons why non-subspecies i salmonellae do not circulate in populations of warm-blooded vertebrates, but instead only cause occasional disease in this niche, are unknown. we examined the ability of salmonella enterica subsp. iiia (subsp. arizonae) and subsp. iiib (subsp. diarizonae) isolates to grow competitively with subspecies i (serovar typhimurium) atcc 14028 in vitro, to colon ... | 2009 | 19218378 |
| role of fimw, fimy, and fimz in regulating the expression of type i fimbriae in salmonella enterica serovar typhimurium. | type i fimbriae in salmonella enterica serovar typhimurium are surface appendages that facilitate binding to eukaryotic cells. expression of the fim gene cluster is known to be regulated by three proteins--fimw, fimy, and fimz--and a trna encoded by fimu. in this work, we investigated how these proteins and trna coordinately regulate fim gene expression. our results indicate that fimy and fimz independently activate the p(fima) promoter which controls the expression of the fim structural genes. ... | 2009 | 19218381 |
| regulation of igaa and the rcs system by the mvia response regulator in salmonella enterica. | igaa is a membrane protein that prevents overactivation of the rcs regulatory system in enteric bacteria. here we provide evidence that igaa is the first gene in a sigma(70)-dependent operon of salmonella enterica serovar typhimurium that also includes yrfg, yrfh, and yrfi. we also show that the lon protease and the mvia response regulator participate in regulation of the igaa operon. our results indicate that mvia regulates igaa transcription in an rpos-dependent manner, but the results also su ... | 2009 | 19218385 |
| antimicrobial susceptibility profiles of salmonella enterica serotypes recovered from pens of commercial feedlot cattle using different types of composite samples. | salmonella enterica in cattle production systems may be associated with important human and animal disease issues. however, tremendous diversity exists among salmonella recovered, and more information is needed about strains of greatest potential health concern, particularly those that are multidrug resistant (mdr). by characterizing salmonella isolates from commercial feedlot pens, this study aimed to evaluate the strain diversity and prevalence of mdr salmonella from different types of composi ... | 2009 | 19219500 |
| global regulators and environmental adaptation in gram-negative pathogens. | a powerful combination of single-gene studies and whole genome approaches has provided a wealth of information about the regulatory circuits used by bacteria to adapt to the environmental changes that are encountered during infection. the facultative intracellular pathogen salmonella enterica will be used to illustrate how global regulators such as the nucleoid-associated proteins fis and h-ns collaborate with fluctuations in the superhelicity of the dna template to modify the gene expression pr ... | 2009 | 19220355 |
| osmoregulated periplasmic glucans are needed for competitive growth and biofilm formation by salmonella enterica serovar typhimurium in leafy-green vegetable wash waters and colonization in mice. | osmoregulated periplasmic glucans (opgs) are major periplasmic constituents of gram-negative bacteria. the role of opgs has been postulated in symbiotic as well as pathogenic host-microorganism interactions. here, we report the role of opgs from salmonella enterica serovar typhimurium during growth and biofilm formation in leafy-green vegetable wash water. the opggh mutant strain, which was defective in opg biosynthesis, initiated the growth at a slower rate in wash waters obtained from spinach, ... | 2009 | 19222578 |
| development of non-antibiotic-resistant, chromosomally based, constitutive and inducible expression systems for aroa-attenuated salmonella enterica serovar typhimurium. | live-vaccine delivery systems expressing two model antigens from mycoplasma hyopneumoniae, f2(p97) (adh) and nrdf, were constructed using salmonella enterica serovar typhimurium aroa (stm-1), and immunogenicity in mice was evaluated. recombinant plasmid-based expression (pbe) and chromosomally based expression (cbe) systems were constructed. the pbe system was formed by cloning both antigen genes into pjla507 to create an operon downstream of temperature-inducible promoters. constitutive cbe was ... | 2009 | 19223478 |
| emergence of plasmid-mediated quinolone resistance among non-typhi salmonella enterica isolates from humans in the united states. | plasmid-mediated quinolone resistance determinants are emerging among gram-negative pathogens. here we report results of a retrospective study investigating the prevalence of aac(6')-ib-cr, qepa, and qnr genes among 19,010 human isolates of non-typhi salmonella enterica collected in the united states from 1996 to 2006. | 2009 | 19223618 |
| screening and characterization of monoclonal antibodies to the surface antigens of listeria monocytogenes serotype 4b. | this study aims to develop and characterize monoclonal antibodies (mabs) with high specificity and affinity for surface antigens of an epidemiologically important serotype 4b of listeria monocytogenes. | 2009 | 19226395 |
| coordinated regulation of virulence during systemic infection of salmonella enterica serovar typhimurium. | to cause a systemic infection, salmonella must respond to many environmental cues during mouse infection and express specific subsets of genes in a temporal and spatial manner, but the regulatory pathways are poorly established. to unravel how micro-environmental signals are processed and integrated into coordinated action, we constructed in-frame non-polar deletions of 83 regulators inferred to play a role in salmonella enteriditis typhimurium (stm) virulence and tested them in three virulence ... | 2009 | 19229334 |
| salmonella paratyphi c: genetic divergence from salmonella choleraesuis and pathogenic convergence with salmonella typhi. | background: although over 1400 salmonella serovars cause usually self-limited gastroenteritis in humans, a few, e.g., salmonella typhi and s. paratyphi c, cause typhoid, a potentially fatal systemic infection. it is not known whether the typhoid agents have evolved from a common ancestor (by divergent processes) or acquired similar pathogenic traits independently (by convergent processes). comparison of different typhoid agents with non-typhoidal salmonella lineages will provide excellent models ... | 2009 | 19229335 |
| genome-wide analysis of the prea/preb (qseb/qsec) regulon of salmonella enterica serovar typhimurium. | the salmonella prea/preb two-component system (tcs) is an ortholog of the qsebc tcs of escherichia coli. in both salmonella and e. coli, this system has been shown to affect motility and virulence in response to quorum-sensing and hormonal signals, and to affect the transcription of the salmonella enterica serovar typhimurium (s. typhimurium) pmrab operon, which encodes an important virulence-associated tcs. | 2009 | 19236707 |
| risk factors for salmonella enterica subsp. enterica contamination in 519 french laying hen flocks at the end of the laying period. | a cross-sectional study was carried out to identify risk factors for salmonella spp. contamination in french laying hen flocks at the end of the laying period. five hundred and nineteen flocks were studied between october 2004 and september 2005. the salmonella status of the flocks was assessed from 5 faeces samples (pooled faeces samples from cage flocks and foot swabs from flocks kept on the floor, i.e. in a barn, outdoors and on organic farms) and 2 dust samples analysed using a classical bac ... | 2009 | 19237216 |
| contribution of flagellin pattern recognition to intestinal inflammation during salmonella enterica serotype typhimurium infection. | salmonella enterica serotype typhimurium causes acute inflammatory diarrhea in humans. flagella contribute to intestinal inflammation, but the mechanism remains unclear since most mutations abrogating pattern recognition of flagellin also prevent motility and reduce bacterial invasion. to determine the contribution of flagellin pattern recognition to the generation of innate immune responses, we compared in two animal models a nonmotile, but flagellin-expressing and -secreting serotype typhimuri ... | 2009 | 19237529 |
| interactions of salmonella enterica with lettuce leaves. | to investigate the interactions of salmonella enterica with abiotic and plant surfaces and their effect on the tolerance of the pathogen to various stressors. | 2009 | 19239550 |
| integron-mediated multidrug resistance in a global collection of nontyphoidal salmonella enterica isolates. | salmonella enterica bacteria have become increasingly resistant to antimicrobial agents, partly as a result of genes carried on integrons. clonal expansion and horizontal gene transfer may contribute to the spread of antimicrobial drug-resistance integrons in these organisms. we investigated this resistance and integron carriage among 90 isolates with the acssut phenotype (resistance to ampicillin, chloramphenicol, streptomycin, sulfamethoxazole, and tetracycline) in a global collection of s. en ... | 2009 | 19239750 |
| cross-protective effect of acid-adapted salmonella enterica on resistance to lethal acid and cold stress conditions. | to evaluate the cross-protected salmonella enterica cells under acid and cold stress conditions. | 2008 | 19241522 |
| salmonella sofia differs from other poultry-associated salmonella serovars with respect to cell surface hydrophobicity. | salmonella enterica is one of the most important foodborne pathogens. salmonella enterica subsp. ii 4,12:b:- (salmonella sofia) is commonly found in australian poultry. it has been suggested that physicochemical properties such as surface charge and hydrophobicity may affect bacterial attachment to surfaces and their ability to persist in food systems. a possible link between hydrophobicity cell surface charge and persistence of salmonella from the poultry system was examined. hydrophobicity of ... | 2008 | 19244894 |
| splenic abscess due to salmonella enterica serotype typhi in a young adult. | 2008 | 19245162 | |
| rpoe fine tunes expression of a subset of ssrb-regulated virulence factors in salmonella enterica serovar typhimurium. | the survival of salmonella enterica within the intracellular host niche requires highly co-ordinated expression of virulence effectors predominantly regulated by the ssrab two-component regulatory system. s. enterica serovar typhimurium mutants lacking the ssrab genes are avirulent in mice, highlighting the importance of this regulatory system in vivo. mutants lacking the gene encoding the alternative sigma factor sigmae (rpoe) are also highly attenuated for intracellular survival, pointing to a ... | 2009 | 19245712 |
| salmonella enterica serovar typhimurium htra: regulation of expression and role of the chaperone and protease activities during infection. | htra is a bifunctional stress protein required by many bacterial pathogens to successfully cause infection. salmonella enterica serovar typhimurium (s. typhimurium) htra mutants are defective in intramacrophage survival and are highly attenuated in mice. transcription of htra in escherichia coli is governed by a single promoter that is dependent on sigma(e) (rpoe). s. typhimurium htra also possesses a sigma(e)-dependent promoter; however, we found that the absence of sigma(e) had little effect o ... | 2009 | 19246758 |
| polyserositis due to salmonellaenterica serovar enteritidis. | salmonella enterica serovar enteritidis (s. enteritidis), a non-typhoid salmonella, is an important emerging pathogen that usually causes gastroenteritis. here, we report polyserositis with right-sided pleural effusion and loculated collection of fluid in the peritoneum caused by s. enteritidis in a 60-year-old man from southern india. the patient was immunocompetent and did not have preceding gastroenteritis or any local structural abnormality. malnutrition and old age might have been the predi ... | 2009 | 19251293 |
| transcription factor function and promoter architecture govern the evolution of bacterial regulons. | evolutionary changes in ancestral regulatory circuits can bring about phenotypic differences between related organisms. studies of regulatory circuits in eukaryotes suggest that these modifications result primarily from changes in cis-regulatory elements (as opposed to alterations in the transcription factors that act upon these sequences). it is presently unclear how the evolution of gene regulatory circuits has proceeded in bacteria, given the rampant effects of horizontal gene transfer, which ... | 2009 | 19251636 |
| identification of escherichia coli and salmonella enterica organisms with reduced susceptibility to ceftriaxone from fecal samples of cows in dairy herds. | to estimate the relationship between therapeutic use of ceftiofur and recovery of escherichia coli and salmonella spp with reduced susceptibility to ceftriaxone from feces of dairy cattle. | 2009 | 19254152 |
| a multiplex real-time pcr for differential detection and quantification of salmonella spp., salmonella enterica serovar typhimurium and enteritidis in meats. | salmonella (s.) typhimurium and s. enteritidis are the major causative agents of food-borne illnesses worldwide. currently, a rapid detection system using multiplex real-time polymerase chain reaction (pcr) has been applied for other food-borne pathogens such as escherichia coli, staphylococcus aureus and streptococcus spp. a multiplex real-time pcr was developed for the simultaneous detection of salmonella spp., especially s. typhimurium and s. enteritidis, in beef and pork. for the specific an ... | 2009 | 19255523 |
| genotyping and antimicrobial susceptibility of salmonella enterica serotype panama isolated in taiwan. | previous studies have indicated that salmonella enterica serotype panama causes systemic infections in humans. the present study was undertaken to gain more understanding of the molecular epidemiology and antimicrobial resistance of salmonella panama. | 2008 | 19255695 |
| rapid detection of salmonella in foods using real-time pcr. | conventional methods for detection of salmonella serovars in foods are generally time-consuming and labor intensive. a real-time pcr method has been developed with custom designed primers and a taqman probe to detect the presence of a 262-bp fragment of the salmonella-specific inva gene. the method has been tested with a total of 384 field-isolated salmonella serovars and non-salmonella stock strains, as well as 420 u.s. food and drug administration food samples, comprising a variety of food mat ... | 2008 | 19256088 |
| a case of multidrug-resistant salmonella enterica serovar typhi treated with a bench to bedside approach. | we report a relapsed case of a 25 year-old man with multi-drug resistant salmonella serovar typhi (mdrst) bacteremia who had recently returned from travel in india. due to unresponsiveness to ciprofloxacin and ceftriaxone, we examined the strain's resistance to quinolones and extended-spectrum beta-lactamases (esbls). the strain had a single gyra mutation at codon 83 (ser83phe), which explains its decreased susceptibility to fluoroquinolone and resistance to nalidixic acid. in the screening test ... | 2009 | 19259362 |
| pseudoinfection due to mislabeling. | 2009 | 19260813 | |
| comparative functional analysis of the rcsc sensor kinase from different enterobacteriaceae. | the rcs phosphorelay is an important signalling pathway that is conserved throughout the enterobacteriaceae. the rcs phosphorelay is composed of the rcsc sensor kinase, a membrane-localized hpt-containing protein rcsd and the cytoplasmic response regulator rcsb. in this study we were interested in studying the degree of functional conservation between the different enteric rcsc homologues. therefore, we tested for the ability of rcsc homologues from pathogenic escherichia coli, salmonella enteri ... | 2009 | 19260968 |
| high-throughput molecular determination of salmonella enterica serovars by use of multiplex pcr and capillary electrophoresis analysis. | salmonella enterica is a leading cause of food-borne illness worldwide and is also a major cause of morbidity and mortality in domestic and wild animals. in the current study, a high-throughput molecular assay was developed to determine the most common clinical and nonhuman serovars of s. enterica in the united states. sixteen genomic targets were identified based on their differential distribution among common serovars. primers were designed to amplify regions of each of these targets in a sing ... | 2009 | 19261787 |
| [reptile-associated salmonellosis in infants in germany]. | salmonellosis is an important disease in childhood. increasing infections caused by meat and raw egg consumption starts in the second year of life. the transmission from reptiles to infants is an alternative route. reptile-associated salmonellosis is becoming more significant for pediatricians and microbiologists due to the increasing numbers of household exotic pets. investigations of routes of infections in connection with the local health authorities including microbiological, serological and ... | 2009 | 19263324 |
| [reptile-associated salmonellosis in a breastfed infant]. | although salmonellosis is one of the most common childhood illnesses associated with enteric bacteria, breastfed babies do not often get infected with salmonella. in such cases it is therefore necessary to look carefully for the source of infection. | 2009 | 19263326 |
| cytoprotective function of heme oxygenase 1 induced by a nitrated cyclic nucleotide formed during murine salmonellosis. | signaling mechanisms of no-mediated host defense are yet to be elucidated. in this study, we report a unique signal pathway for cytoprotection during salmonella infection that involves heme oxygenase 1 (ho-1) induced by a nitrated cyclic nucleotide, 8-nitroguanosine 3',5'-cyclic monophosphate (8-nitro-cgmp). wild-type c57bl/6 mice and c57bl/6 mice lacking inducible no synthase (inos) were infected with salmonella enterica serovar typhimurium lt2. ho-1 was markedly up-regulated during the infecti ... | 2009 | 19265153 |
| fate of the h-ns-repressed bgl operon in evolution of escherichia coli. | in the enterobacterial species escherichia coli and salmonella enterica, expression of horizontally acquired genes with a higher than average at content is repressed by the nucleoid-associated protein h-ns. a classical example of an h-ns-repressed locus is the bgl (aryl-beta,d-glucoside) operon of e. coli. this locus is "cryptic," as no laboratory growth conditions are known to relieve repression of bgl by h-ns in e. coli k12. however, repression can be relieved by spontaneous mutations. here, w ... | 2009 | 19266030 |
| purified recombinant phage lysin lysmp: an extensive spectrum of lytic activity for swine streptococci. | bacteriophage lysin has attracted considerable attentions as possible antimicrobial agents for solution of antibiotic resistance. smp was a streptococcus suis serotype 2 bacteriophage isolated from nasal swabs of healthy bama minipigs. the putative smp bacteriophage lysin, designated lysmp, was recombinantly expressed in escherichia coli bl21, and chromatographically purified. treated with 0.8% of beta-mercaptoethanol, lysmp exhibited an extensive lysin spectrum than those of whole phage against ... | 2009 | 19267155 |
| a filtration-based real-time pcr method for the quantitative detection of viable salmonella enterica and listeria monocytogenes in food samples. | we developed a novel filtration-based method that can eliminate dead or severely damaged salmonella enterica and listeria monocytogenes in food samples. this new method can recover all viable bacteria in less than 30 min, and can be coupled with a subsequent bacterial dna extraction and real-time pcr. no statically significant differences (p<0.01) were found between real-time pcr results obtained separately from s. enterica and l. monocytogenes when different ratios of living and dead cells were ... | 2009 | 19269574 |
| bilateral periprosthetic joint infection caused by salmonella enterica serotype enteritidis, and identification of salmonella sp using molecular techniques. | salmonella septic arthritis is rare. our objective was to identify bacterial species from joint fluid using a broad-range real-time pcr and pyrosequencing technique. we describe a case of bilateral salmonella enterica serotype enteritidis infection of right and left total knee arthroplasties. dna was extracted from the joint fluid of the left knee, amplified by pcr, and the amplicons were evaluated by pyrosequencing. the patient was treated with ciprofloxacin, and the polyethylene liners were re ... | 2009 | 19269872 |
| percolation and survival of escherichia coli o157:h7 and salmonella enterica serovar typhimurium in soil amended with contaminated dairy manure or slurry. | the effect of cattle manure and slurry application on percolation and survival of escherichia coli o157:h7 and salmonella enterica serovar typhimurium was investigated for different soil depths after the addition of water. four treatments were chosen for the first set of experiments: (i) addition of inoculated farmyard manure on the soil surface, (ii) mixing of inoculated farmyard manure with the top 10 cm of soil, (iii) addition of inoculated slurry on the soil surface, and (iv) injection of in ... | 2009 | 19270130 |
| influence of a probiotic strain of enterococcus faecium on salmonella enterica serovar typhimurium dt104 infection in a porcine animal infection model. | the beneficial effects of probiotic enterococcus spp. in different hosts, such as mice and humans, have previously been reported in several studies. however, studies of large domestic animals, as well as challenge studies with pathogenic microorganisms, are very rare. here, we investigated the influence of oral treatment of pigs with the probiotic bacterium enterococcus faecium ncimb 10415 on salmonella enterica serovar typhimurium dt104 infections in weaning piglets. clinical symptoms, fecal ex ... | 2009 | 19270131 |
| ciprofloxacin selects for multidrug resistance in salmonella enterica serovar typhimurium mediated by at least two different pathways. | the aim of this study was to understand the role of rama in conferring multidrug resistance (mdr) in salmonella enterica serovar typhimurium. | 2009 | 19270312 |
| environmental salmonella surveillance in the ohio state university veterinary teaching hospital. | sampling was conducted at the ohio state university's veterinary teaching hospital (osu-vth) to evaluate the extent of environmental contamination with salmonella enterica, at 1-week intervals beginning march 19, 2007, through may 21, 2007. environmental samples were collected from various surface and floor locations in the equine and food animal areas using sterile moistened gauze sponges. all samples were processed using standard bacteriologic culture to identify the presence of salmonella spp ... | 2009 | 19272003 |
| development of triclosan and antibiotic resistance in salmonella enterica serovar typhimurium. | the possible association between the use of triclosan and the development of antibiotic resistance was examined in triclosan-resistant mutants of salmonella enterica serovar typhimurium. these mutants were obtained from a sensitive parental strain and from ciprofloxacin-resistant isogenic strains using spontaneous mutagenesis or selection after one short exposure or continuous exposure to low concentrations of triclosan. the results showed that triclosan in the environment does not increase the ... | 2009 | 19273638 |
| novel plasmid-encoded ceftazidime-hydrolyzing ctx-m-53 extended-spectrum beta-lactamase from salmonella enterica serotypes westhampton and senftenberg. | we describe the characterization of a novel ctx-m beta-lactamase from salmonella enterica. four s. enterica isolates (three of serotype westhampton and one of serotype senftenberg) resistant to extended-spectrum cephalosporins (cefotaxime and ceftazidime) were recovered in 2004 from living cockles in three supermarkets located in distant geographic areas in france, which got their supplies from the same fishery. the isolates were found to produce a novel extended-spectrum beta-lactamase (esbl) b ... | 2009 | 19273683 |
| chromosomal integration of the extended-spectrum beta-lactamase gene blactx-m-15 in salmonella enterica serotype concord isolates from internationally adopted children. | we report the emergence of salmonella enterica isolates of serotype concord (and its monophasic variant 6,7:l,v:-) producing the extended-spectrum beta-lactamases (esbls) shv-12 and ctx-m-15 in france and norway between 2001 and 2006 (43 in france and 26 in norway). the majority of these isolates were from adopted children from ethiopia, most of whom were healthy carriers. several symptomatic secondary cases were found in the adoptive families and health care facilities in france. serotype conco ... | 2009 | 19273688 |
| genetic lines differ in toll-like receptor gene expression in spleens of chicks inoculated with salmonella enterica serovar enteritidis. | toll-like receptors (tlr) recognize evolutionarily conserved molecular motifs (pathogen-associated molecular patterns) of infectious microbes and initiate innate immune response upon activation with relevant pathogens. this study investigated the acute effect of salmonella enteritidis challenge on tlr mrna expression in cecum and spleen of birds from 3 distinct genetic lines. chicks from broiler, leghorn, and fayoumi lines were inoculated or mock-inoculated with salmonella enteritidis. the mrna ... | 2009 | 19276417 |
| antimicrobial susceptibilities, phage types, and molecular characterization of salmonella enterica serovar enteritidis from chickens and chicken meat in turkey. | thirty-eight salmonella enteritidis isolates from chickens and chicken meat in turkey were examined for antimicrobial susceptibility, xbai pulsed-field gel electrophoresis (pfge) patterns, phage types, plasmid profiles, and resistance genes. seven different pfge patterns were observed, with the most common accounting for 71% (x1). the most common phage type was pt4, followed by pt7, pt16, pt1, pt6, and pt35. different phage types shared the same pfge pattern. twenty-one isolates were susceptible ... | 2009 | 19278340 |
| nontyphoidal salmonella serovars cause different degrees of invasive disease globally. | 2009 | 19281309 | |
| multistate outbreak of salmonella typhimurium and saintpaul infections associated with unpasteurized orange juice--united states, 2005. | infection due to salmonella species causes an estimated 1.4 million illnesses and 400 deaths annually in the united states. orange juice is a known vehicle of salmonellosis, for which regulatory controls have recently been implemented. we investigated a nationwide outbreak of salmonella infection to determine the magnitude of the outbreak and to identify risk factors for infection. | 2009 | 19281328 |
| bacteriological detection of salmonella enteritidis in eggs: a review. | the detection of salmonella enterica serovar enteritidis (se) in eggs is hampered by a typically low prevalence of contaminated eggs, the low number of se organisms in such eggs, and the presence of inhibitory substances in the egg albumin. for these reasons, the analysis of large pools of eggs is normally necessary, which presents logistic and microbiological challenges associated with a low number of target organisms from a large volume of sample matrix. in some studies using artificially inoc ... | 2008 | 19284035 |
| regulation of expression of the tricarballylate utilization operon (tcuabc) of salmonella enterica. | the tricarballylate utilization locus (tcurabc) of salmonella enterica serovar typhimurium is comprised of a 3-gene operon (tcuabc) that encodes functions that allow this bacterium to use tricarballylate as a source of carbon and energy, and the tcur gene, which encodes a putative lysr-type transcriptional regulator. in our studies, transcription of the tcuabc operon peaked at mid-log phase, and declined moderately during stationary phase. this pattern was not due to a change in the amount of tc ... | 2009 | 19284970 |
| an increase in enteric fever cases due to salmonella paratyphi a in & around chandigarh. | enteric fever is a major public health problem in india. it is classically caused by salmonella enterica serotype typhi. salmonella enterica serotype paratyphi a which had been reported less frequently from cases of enteric fever has shown an increasing trend since 1996 in india. there is also variation in the antimicrobial susceptibility of salmonella paratyphi a from different parts of the country. an attempt is therefore made to study the rate of isolation and antimicrobial susceptibility pat ... | 2009 | 19287065 |
| an additional novel antimicrobial resistance gene cluster in salmonella genomic island 1 of a salmonella enterica serovar typhimurium dt104 human isolate. | the multi-antimicrobial resistance gene cluster and its derivatives have been detected in salmonella genomic island 1 (sgi1), which has been identified in the salmonella enterica serovar typhimurium, phage types dt104, dt12, dt120, and u302, as well as other salmonella serovars, including agona, paratyphi b, albany, meleagridis, newport, cerro, derby, dusseldorf, infantis, kiambu, and emek. we acquired 53 salmonella typhimurium dt104 isolates from diarrheal patients in korea. from these isolates ... | 2009 | 19292580 |
| emergence, distribution, and molecular and phenotypic characteristics of salmonella enterica serotype 4,5,12:i:-. | salmonella spp. represent one of the most common causes of bacterial foodborne illnesses around the world. the species salmonella enterica contains more than 2500 serotypes, and emergence of new human pathogenic salmonella strains and serotypes represents a major public health issue. salmonella enterica subsp. enterica serotype 4,5,12:i:- represents a monophasic variant of salmonella typhimurium, which has rarely been identified before the mid-1990 s. the prevalence of this serotype among human ... | 2009 | 19292687 |
| characterization of pathogenic and resistant genome repertoire reveals two clonal lines in salmonella enterica subsp. enterica serovar paratyphi b (+)-tartrate positive. | a total of 36 contemporary human, animal, and environmental (+)-tartrate-fermenting (dt+) salmonella enterica serovar paratyphi b isolates, formerly called salmonella serovar java, and five related monophasic s. enterica serovar 4,5,12:b:- isolates from belgium, germany, the netherlands, and the united kingdom were investigated for clonality and antimicrobial resistance profiles, as well as their virulence and resistance gene repertoire. two major clonal lines, which could be phenotypically diff ... | 2009 | 19292689 |
| investigation of an outbreak of salmonella enterica serovar newport infection. | a large outbreak of salmonella enterica serotype newport infection occurred in northern ireland during september and october 2004. typing of isolates from patients confirmed that this strain was indistinguishable from that in concurrent outbreaks in regions of england, in scotland and in the isle of man. a total of 130 cases were distributed unequally across local government district areas in northern ireland. the epidemic curve suggested a continued exposure over about 4 weeks. a matched case-c ... | 2009 | 19296871 |
| differential il-23 requirement for il-22 and il-17a production during innate immunity against salmonella enterica serovar enteritidis. | early activation of the il-12/ifn-gamma axis has been shown following salmonella enterica serovar enteritidis (s. enteritidis) infection. we were interested to study whether il-22 and il-17a production is initiated early in response to s. enteritidis. we demonstrate here that il-22 was strongly elevated in the peritoneal lavage fluid and in serum already 1 day post-intraperitoneal infection (d.p.i.) of mice; not only il-22 but also il-17a was produced ex vivo by activated peritoneal exudate cell ... | 2009 | 19297659 |
| novel approach to control salmonella enterica by modern biophotonic technology: photosensitization. | salmonellosis is one of the most common foodborne diseases in the world. the aim of this study was to evaluate the antibacterial efficiency of 5-aminolevulinic acid (ala) based photosensitization against one of food pathogens salmonella enterica. | 2009 | 19302098 |
| phagocytic superoxide specifically damages an extracytoplasmic target to inhibit or kill salmonella. | the phagocytic oxidative burst is a primary effector of innate immunity that protects against bacterial infection. however, the mechanism by which reactive oxygen species (ros) kill or inhibit bacteria is not known. it is often assumed that dna is a primary target of oxidative damage, consistent with known effects of endogenously produced ros in the bacterial cytoplasm. but most studies fail to distinguish between effects of host derived ros versus damage caused by endogenous bacterial sources. ... | 2009 | 19305502 |
| mesoscopic and microstructural characterization of liposomes formed by the lipooligosaccharide from salmonella minnesota strain 595 (re mutant). | large unilamellar liposomes formed by the re lps (from here below named los) from salmonella enterica serotype minnesota strain 595 (re mutant) have been prepared by the extrusion techniques. the physico-chemical investigation of these systems has been performed by a combined experimental strategy, which has allowed a characterization at different observation scales, from the morphological to the micro-structural level. particularly, dynamic light scattering (dls) measurements have revealed the ... | 2009 | 19305906 |
| unusual class 1 integron-associated gene cassette configuration found in inca/c plasmids from salmonella enterica. | inca/c plasmids carrying an unusual cassette configuration in a class 1 integron and five further shared resistance genes, aacc4, apha1, hph, sul2, and teta(d) were found in salmonella enterica serovars senftenberg and ohio. a deletion formed using a short region of homology in the 5' conserved segment and the orff cassette created an array with only part of orff followed by the aada2 cassette. the inca/c plasmids were not recoverable by conjugation, but additional conjugative resistance plasmid ... | 2009 | 19307357 |
| omeprazole antagonizes virulence and inflammation in salmonella enterica-infected raw264.7 cells. | the proton pump inhibitor omeprazole reduced the intracellular replication of salmonella enterica serovar typhimurium in raw264.7 cells without affecting bacterial growth in vitro or the viability of the host cells. the mechanism was bacteriostatic and interfered with replication mediated by the virulence-associated spi2 type iii secretion system. the proton pump inhibitor bafilomycin a(1), in contrast, mediated killing of intracellular bacteria and imposed a marked cytotoxicity on raw264.7 cell ... | 2009 | 19307359 |
| invited review: breaking barriers--attack on innate immune defences by omptin surface proteases of enterobacterial pathogens. | the omptin family of gram-negative bacterial transmembrane aspartic proteases comprises surface proteins with a highly conserved beta-barrel fold but differing biological functions. the omptins ompt of escherichia coli, pgte of salmonella enterica, and pla of yersinia pestis differ in their substrate specificity as well as in control of their expression. their functional differences are in accordance with the differing pathogenesis of the infections caused by e. coli, salmonella, and y. pestis, ... | 2009 | 19318417 |
| microarray analysis of antimicrobial resistance genes in salmonella enterica from preharvest poultry environment. | to detect antimicrobial resistance genes in salmonella isolates from turkey flocks using the microarray technology. | 2009 | 19320942 |
| functions exerted by the virulence-associated type-three secretion systems during salmonella enterica serovar enteritidis invasion into and survival within chicken oviduct epithelial cells and macrophages. | salmonella enterica serovar enteritidis (se) infection of chickens is a major contributing factor to non-typhoidal salmonellosis. the roles of the type-three secretion systems (t3ss-1 and t3ss-2) in the pathogenesis of se infection of chickens are poorly understood. in this study, the functions of t3ss-1 and t3ss-2 during se infection of primary chicken oviduct epithelial cells (coec) and macrophages were characterized. the t3ss-1 and t3ss-2 mutants (sipb and ssav), impaired in translocation and ... | 2009 | 19322708 |
| in vitro evaluation of a new cefixime-clavulanic acid combination for gram-negative bacteria. | the study was conducted to evaluate a new cefixime-clavulanic acid combination for in vitro susceptibility towards gram-negative bacteria. a total of 220 isolates of escherichia coli, klebsiella pneumoniae, pseudomonas aeroginosa, acinetobacter spp, salmonella enterica serovar typhi and salmonella enterica serovar typhimurium were included in the study. the isolates were tested for susceptibility towards the new combination antimicrobial molecule cefixime with clavulanic acid by disk diffusion a ... | 2009 | 19323045 |
| role of pre-a motif in nitric oxide scavenging by truncated hemoglobin, hbn, of mycobacterium tuberculosis. | mycobacterium tuberculosis truncated hemoglobin, hbn, is endowed with a potent nitric-oxide dioxygenase activity and has been found to relieve nitrosative stress and enhance in vivo survival of a heterologous host, salmonella enterica typhimurium, within the macrophages. these findings implicate involvement of hbn in the defense of m. tuberculosis against nitrosative stress. the protein carries a tunnel system composed of a short and a long tunnel branch that has been proposed to facilitate diat ... | 2009 | 19329431 |
| interaction of candida albicans with an intestinal pathogen, salmonella enterica serovar typhimurium. | candida albicans is an opportunistic human fungal pathogen that normally resides in the gastrointestinal tract and on the skin as a commensal but can cause life-threatening invasive disease. salmonella enterica serovar typhimurium is a gram-negative bacterial pathogen that causes a significant amount of gastrointestinal infection in humans. both of these organisms are also pathogenic to the nematode caenorhabditis elegans, causing a persistent gut infection leading to worm death. in the present ... | 2009 | 19329669 |
| myxinidin, a novel antimicrobial peptide from the epidermal mucus of hagfish, myxine glutinosa l. | fish epidermal mucus contains innate immune components that provide a first line of defense against various infectious pathogens. this study reports the bioassay-guided fractionation and characterization of a novel antimicrobial peptide, myxinidin, from the acidic epidermal mucus extract of hagfish (myxine glutinosa l.). edman sequencing and mass spectrometry revealed that myxinidin consists of 12 amino acids and has a molecular mass of 1,327.68 da. myxinidin showed activity against a broad rang ... | 2009 | 19330556 |
| aquaculture and florfenicol resistance in salmonella enterica serovar typhimurium dt104. | 2009 | 19331756 | |
| emergence and evolution of multiply antibiotic-resistant salmonella enterica serovar paratyphi b d-tartrate-utilizing strains containing sgi1. | the first australian isolate of salmonella enterica serovar paratyphi b d-tartrate-utilizing (dt(+)) that is resistant to ampicillin, chloramphenicol, florfenicol, streptomycin, spectinomycin, sulfonamides, and tetracycline (apcmflsmspsutc) and contains sgi1 was isolated from a patient with gastroenteritis in early 1995. this is the earliest reported isolation globally. the incidence of infections caused by these sgi1-containing multiply antibiotic-resistant s. enterica serovar paratyphi b dt(+) ... | 2009 | 19332668 |