Publications
| Title | Abstract | Year Filter | PMID(sorted ascending) Filter |
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| diagnostic sensitivity of a rapid antigen test for the detection of mycoplasma pneumoniae: comparison with real-time pcr. | a rapid antigen kit for the detection of the mycoplasma pneumoniae ribosomal protein l7/l12 using an immunochromatographic assay, ribotest mycoplasma, became available in japan in 2013. to determine the sensitivity of ribotest compared with real-time polymerase chain reaction (pcr), we prospectively performed these two tests simultaneously in adolescent and adult patients with community-acquired pneumonia (cap). in addition, we retrospectively analyzed the theoretical sensitivity of ribotest usi ... | 2015 | 25818195 |
| macroscopic haemoglobinuria associated with mycoplasma pneumoniae infection successfully treated by clarithromycin. | a 25-year-old man developed macroscopic haemoglobinuria after a persistent dry cough. although chest radiograph findings were normal, since the serum antibody for mycoplasma pneumoniae was significantly elevated, a diagnosis infection with this organism was made. despite the absence of apparent anaemia, a marked increase in serum haemolytic markers and positive result for urine haemoglobin indicated the haemolysis of red blood cells, which was likely to have occurred secondarily to m. pneumoniae ... | 2015 | 25819056 |
| in vitro antibacterial activity of azd0914 against human mycoplasmas and ureaplasmas. | in this study, susceptibilities were determined for azd0914, a spiropyrimidinetrione dna gyrase inhibitor, azithromycin, doxycycline, and levofloxacin against mycoplasma and ureaplasma species. the activity of azd0914 was comparable to that of levofloxacin and doxycycline against mycoplasma genitalium and mycoplasma pneumoniae. the azd0914 mic90 against mycoplasma hominis was 8-fold greater than that for levofloxacin. the azd0914 mic90 against ureaplasma species was 4-fold less than that for azi ... | 2015 | 25824220 |
| characteristics of respiratory syncytial virus-induced bronchiolitis co-infection with mycoplasma pneumoniae and add-on therapy with montelukast. | the influence of mycoplasma pneumoniae (mp) infection on bronchiolitis remains unclear. additionally, reports on the efficacies of leukotriene receptor antagonists in the treatment of bronchiolitis have been inconclusive. | 2016 | 25846070 |
| structure of cards toxin, a unique adp-ribosylating and vacuolating cytotoxin from mycoplasma pneumoniae. | mycoplasma pneumoniae (mp) infections cause tracheobronchitis and "walking" pneumonia, and are linked to asthma and other reactive airway diseases. as part of the infectious process, the bacterium expresses a 591-aa virulence factor with both mono-adp ribosyltransferase (mart) and vacuolating activities known as community-acquired respiratory distress syndrome toxin (cards tx). cards tx binds to human surfactant protein a and annexin a2 on airway epithelial cells and is internalized, leading to ... | 2015 | 25848012 |
| surveillance for seasonal influenza virus prevalence in hospitalized children with lower respiratory tract infection in guangzhou, china during the post-pandemic era. | influenza a(h1n1)pdm09, a(h3n2) and b viruses have co-circulated in the human population since the swine-origin human h1n1 pandemic in 2009. while infections of these subtypes generally cause mild illnesses, lower respiratory tract infection (lrti) occurs in a portion of children and required hospitalization. the aim of our study was to estimate the prevalence of these three subtypes and compare the clinical manifestations in hospitalized children with lrti in guangzhou, china during the post-pa ... | 2015 | 25867910 |
| thrombocytopenia associated with mycoplasma pneumonia during pregnancy: case presentation and approach for differential diagnosis. | thrombocytopenia during pregnancy has many different causes, but mycoplasma pneumoniae is not usually considered one of the several pathogens that induce thrombocytopenia. herein, we present a case of severe thrombocytopenia that was associated with m. pneumoniae during pregnancy. the patient experienced fever, cough, and cytopenia with m. pneumoniae-specific igm antibody increasing from 40-fold to 160-fold during the 2 weeks of illness. a diagnosis was made after excluding other diseases that c ... | 2015 | 25873353 |
| bronchiectasis exacerbations: the role of atypical bacteria, respiratory syncytial virus and pulmonary function tests. | aside from the known role of common bacteria, there is a paucity of data regarding the possible role of atypical bacteria and viruses in exacerbations of non-cystic fibrosis bronchiectasis. | 2015 | 25874735 |
| [a case report of pulmonary embolism associated with mycoplasma pneumoniae pneumonia]. | 2015 | 25876692 | |
| mycoplasma pneumoniae and chlamydophila pneumoniae in hospitalized children with bronchiolitis. | bronchiolitis is an acute lower respiratory tract infection in early childhood caused mainly by different viruses. etiology of bronchiolitis have been studied in different environments and populations. respiratory syncytial virus (rsv), human metapneumovirus (hmpv), human bocavirus (hbov), human rhinoviruses (hrv) have consistently been shown to predominate. few studies however have attempted to determine whether other pathogens, particularly mycoplasma pneumoniae (mp) and chlamydophila pneumoni ... | 2015 | 25879563 |
| severe acute respiratory infection in children in a densely populated urban slum in kenya, 2007-2011. | reducing acute respiratory infection burden in children in africa remains a major priority and challenge. we analyzed data from population-based infectious disease surveillance for severe acute respiratory illness (sari) among children <5 years of age in kibera, a densely populated urban slum in nairobi, kenya. | 2015 | 25879805 |
| the aetiology of community associated pneumonia in children in nanjing, china and aetiological patterns associated with age and season. | viral and atypical bacterial pathogens play an important role in respiratory tract infection. using the pneumoslide igm test, the presented study explored the aetiology of community-acquired pneumonia and investigated further whether there was an association between age or season and aetiological organisms. | 2015 | 25879996 |
| mycoplasma iowae: relationships among oxygen, virulence, and protection from oxidative stress. | the poultry-associated bacterium mycoplasma iowae colonizes multiple sites in embryos, with disease or death resulting. although m. iowae accumulates in the intestinal tract, it does not cause disease at that site, but rather only in tissues that are exposed to atmospheric o2. the activity of m. iowae catalase, encoded by kate, is capable of rapid removal of damaging h2o2 from solution, and kate confers a substantial reduction in the amount of h2o2 produced by mycoplasma gallisepticum kate trans ... | 2015 | 25880161 |
| absence of inferior vena cava in 14-year old boy associated with deep venous thrombosis and positive mycoplasma pneumoniae serum antibodies--a case report. | absence of the inferior vena cava is a rare vascular anomaly, which usually remains asymptomatic in childhood. it is recognized as the risk factor for deep venous thrombosis, since the collateral circulation does not provide adequate drainage of the lower limbs. mycoplasma pneumoniae is a common cause of community-acquired pneumonia in school-aged children and adolescents. mycoplasma pneumoniae infection might be associated with deep venous thrombosis but its pathophysiology remains unknown. acc ... | 2015 | 25880637 |
| etiology of community-acquired pneumonia and diagnostic yields of microbiological methods: a 3-year prospective study in norway. | despite recent advances in microbiological techniques, the etiology of community-acquired pneumonia (cap) is still not well described. we applied polymerase chain reaction (pcr) and conventional methods to describe etiology of cap in hospitalized adults and evaluated their respective diagnostic yields. | 2015 | 25887603 |
| left ventricular thrombus in a patient with cutaneous t-cell lymphoma, hypereosinophilia and mycoplasma pneumoniae infection - a challenging diagnosis: a case report. | differential diagnoses of cardiac masses include primary benign and malignant neoplasms, secondary neoplasms, and non-neoplastic masses, such as thrombi. owing to different therapeutic approaches and the way these affect the prognosis, the early and correct diagnostic determination of the etiology of a cardiac mass is of utmost importance and essential for the appropriate management of patients.we report a case of a 52-year-old woman with a left ventricular mass in the setting of a recent mycopl ... | 2015 | 25889614 |
| catalase enhances growth and biofilm production of mycoplasma pneumoniae. | mycoplasma pneumoniae causes chronic respiratory disease in humans. factors thought to be important for colonization include the ability of the mycoplasma to form a biofilm on epithelial surfaces and the production of hydrogen peroxide to damage host tissue. almost all of the mycoplasmas, including m. pneumoniae, lack superoxide dismutase and catalase and a balance should exist between peroxide production and growth. we show here that the addition of catalase to cultures enhanced the formation o ... | 2015 | 25894997 |
| [determination of th9 cells and il-9 in children with mycoplasma pneumoniae infection]. | to investigate the clinical significance of t helper type 9 (th9) cells and interleukin-9 (il-9) in children suffering from mycoplasma pneumoniae (mp) infection. | 2015 | 25919545 |
| 50 years ago in the journal of pediatrics: mycoplasma pneumoniae (eaton atypical pneumonia agent) in children's respiratory infections. | 2015 | 25919730 | |
| design of pcr-based method for detection of a gene-encoding mycoplasma arthritidis mitogen superantigen in synovial fluid of rheumatoid arthritis patients. | mycoplasma arthritidis mitogen (mam) superantigen has been shown to induce chronic arthritis, which resembles human rheumatoid arthritis (ra) in a rodent model. however, its role as a causative agent in human ra is not well understood yet. the aim of this study was to investigate the presence of mam superantigen gene in the synovial fluid (sf) of ra patients. | 2014 | 25926960 |
| reactive arthritis in relation to internal derangements of the temporomandibular joint: a case control study. | the aim of this study was to find out if reactive arthritis was involved in the aetiology of chronic closed lock of the temporomandibular joint (tmj) by looking for bacterial antigens in the synovial membrane of the tmj, and by studying the antibody serology and carriage of human leucocyte antigen (hla) b27 in patients with chronic closed lock. patients with reciprocal clicking and healthy subjects acted as controls. we studied a total of 43 consecutive patients, 15 with chronic closed lock, 13 ... | 2015 | 25957137 |
| genetic variation in sp-a2 leads to differential binding to mycoplasma pneumoniae membranes and regulation of host responses. | mycoplasma pneumoniae is an extracellular pathogen that colonizes mucosal surfaces of the respiratory tract and is associated with asthma exacerbations. previous reports demonstrate that surfactant protein-a (sp-a) binds live m. pneumoniae and mycoplasma membrane fractions (mmf) with high affinity. humans express a repertoire of single-amino acid genetic variants of sp-a that may be associated with lung disease, and our findings demonstrate that allelic differences in sp-a2 (gln223lys) affect th ... | 2015 | 25957169 |
| epidemiology and clinical profiles of mycoplasma pneumoniae infection in hospitalized infants younger than one year. | mycoplasma pneumoniae (m. pneumoniae) is an important pathogen of community-acquired pneumonia in children, but the epidemiology and clinical features of m. pneumoniae infection in infants are reported in only a few studies. this study aims to evaluate possible age-related differences in the presenting clinical features in infants with m. pneumoniae infection. | 2015 | 25957828 |
| bordetella pertussis is an uncommon pathogen in children hospitalized with bronchiolitis during the winter season. | in the united states (u.s.), bordetella pertussis incidence has increased. cough and apnea are common findings in pertussis and also in bronchiolitis, the most common cause of hospitalization in u.s. infants. the objective was to determine the prevalence of b. pertussis infection in children hospitalized with bronchiolitis and to describe its clinical course. | 2015 | 25970109 |
| reversible bilateral striatal lesions following mycoplasma pneumoniae infection associated with elevated levels of interleukins 6 and 8. | reversible bilateral striatal necrosis associated with mycoplasma pneumoniae (m. pneumoniae) infection is a rare neurological disease. the exact pathogenic mechanism remains unknown. | 2016 | 25972305 |
| subunits of the pyruvate dehydrogenase cluster of mycoplasma pneumoniae are surface-displayed proteins that bind and activate human plasminogen. | the dual role of glycolytic enzymes in cytosol-located metabolic processes and in cell surface-mediated functions with an influence on virulence is described for various micro-organisms. cell wall-less bacteria of the class mollicutes including the common human pathogen mycoplasma pneumoniae possess a reduced genome limiting the repertoire of virulence factors and metabolic pathways. after the initial contact of bacteria with cells of the respiratory epithelium via a specialized complex of adhes ... | 2015 | 25978044 |
| viral and atypical bacterial aetiologies of infection in hospitalised patients admitted with clinical suspicion of influenza in thailand, vietnam and indonesia. | influenza constitutes a leading cause of morbidity and mortality worldwide. there is limited information about the etiology of infection presenting clinically as influenza in hospitalized adults and children in southeast asia. such data are important for future management of respiratory infections. | 2015 | 25980749 |
| cutaneous vasculitis and renal involvement in mycoplasma pneumoniae infection. | 2015 | 25995672 | |
| enzymatic amplification-free nucleic acid hybridisation sensing on nanostructured thick-film electrodes by using covalently attached methylene blue. | amplification-free (referring to enzymatic amplification step) detection methodologies are increasing in biosensor development due to the need of faster and simpler protocols. however, for maintaining sensitivity without this step, highly detectable molecules or very sensitive detection techniques are required. the nanostructuration of transducer surfaces with carbon nanotubes (cnts), gold nanoparticles (aunps) or both in nanohybrid configurations has been employed in this work for dna hybridisa ... | 2015 | 26003686 |
| pathogenesis and association of mycoplasma pneumoniae infection with cardiac and hepatic damage. | the aim of this study was to investigate the pathogenesis of mycoplasma pneumoniae (mp) infection and its association with cardiac and hepatic damage. between march 2013 and march 2014, 59 children with mp pneumonia (mpp) and 30 healthy children were enrolled. serum titers of tlr4, t cell immunoglobulin and mucin-domain (tim) 3, il-10, tnf-α, and ifn-γ were measured both in children with mpp and healthy children. additionally, mp-specific antibody titer and creatine kinase-mb (ck-mb), and alanin ... | 2015 | 26011190 |
| [prognostic judgment of children with mycoplasma pneumoniae pneumonia associated with airway mucous plug formation]. | to investigate the clinical characteristics and treatment defects in slow-to-recover children with mycoplasma pneumoniae pneumonia (mpp) associated with airway mucous plug formation, and to provide a basis for prognostic judgment and therapeutic guidance. | 2015 | 26014701 |
| volatile organic compounds generated by cultures of bacteria and viruses associated with respiratory infections. | respiratory infections (ri) can be viral or bacterial in origin. in either case, the invasion of the pathogen results in production and release of various volatile organic compounds (vocs). the present study examines the vocs released from cultures of five viruses (influenza a, influenza b, adenovirus, respiratory syncitial virus and parainfluenza 1 virus), three bacteria (moraxella catarrhalis, haemophilus influenzae and legionella pneumophila) and mycoplasma pneumoniae isolated colonies. our r ... | 2015 | 26033043 |
| mycoplasma pneumoniae pneumonia associated with methemoglobinemia and anemia: an overlooked association? | we report a case of acute methemoglobinemia and anemia in a patient with mycoplasma pneumoniae pneumonia. we suggest that m. pneumoniae secretes a putative protein that can induce methemoglobin in red blood cells. thus, mycoplasma pneumoniae may induce methemoglobinemia in patients who have low oxygen saturation and anemia. | 2015 | 26034771 |
| avian influenza a h5n1 virus: a continuous threat to humans. | we report the first case of severe pneumonia due to co-infection with the emerging avian influenza a (h5n1) virus subclade 2.3.2.1 and mycoplasma pneumoniae. the patient was a returning traveller who had visited a poultry market in south china. we then review the epidemiology, virology, interspecies barrier limiting poultry-to-human transmission, clinical manifestation, laboratory diagnosis, treatment and control measures of h5n1 clades that can be transmitted to humans. the recent controversy r ... | 2012 | 26038430 |
| [neurological symptoms due to mycoplasma pneumoniae infection in nine children]. | mycoplasma pneumoniae infection is common in children. extrapulmonary symptoms usually reveal as neurological symptoms, mainly as encephalitis with significant morbidity and mortality. various other neurological presentations have also been reported. we describe a cohort of nine children with neurological manifestations due to m. pneumoniae infection, including five cases of encephalitis, one of polyradiculoneuritis, one of ophthalmoplegia, one of optic neuritis, and one of myositis. progression ... | 2015 | 26047743 |
| mycoplasma pneumoniae infection in adults with acute and chronic urticaria. | 2015 | 26057513 | |
| simultaneous detection of mycoplasma pneumoniae, mycoplasma hominis and mycoplasma arthritidis in synovial fluid of patients with rheumatoid arthritis by multiplex pcr. | it has been recognized that infectious agents, such as different bacteria and viruses, may play a role in the developing of rheumatoid arthritis (ra). recently, the mycoplasma species has been implicated in the pathogenesis of ra. | 2015 | 26058928 |
| lactate dehydrogenase as a biomarker for prediction of refractory mycoplasma pneumoniae pneumonia in children. | corticosteroids have been used for refractory mycoplasma pneumoniae pneumonia and have beneficial effects. the aim of this study was to identify the biomarkers for predicting refractory m. pneumoniae pneumonia in a timely fashion to initiate steroid therapy. | 2015 | 26060318 |
| changes of serum tnf-α, il-5 and ige levels in the patients of mycoplasma pneumonia infection with or without bronchial asthma. | this study aimed to investigate the changes of serum levels of tnf-α, il-5 and ige in mycoplasma pneumonia (mp) infection patients with or without bronchial asthma and explore its clinical importance. | 2015 | 26064291 |
| unusual eruptions associated with mycoplasma pneumoniae respiratory infections: review of the literature. | maculopapular or urticarial eruptions and erythema multiforme sometimes occur in patients affected with mycoplasma pneumoniae respiratory infections. further eruptions have also been reported. | 2015 | 26067570 |
| hemorrhagic encephalitis caused by mycoplasma pneumoniae in an 11-year-old boy: a rare case report. | 2015 | 26068367 | |
| eeg extreme delta brush: an ictal pattern in patients with anti-nmda receptor encephalitis. | the anti-nmda receptor (nmdar) encephalitis-associated syndrome includes neuropsychiatric symptoms, impaired consciousness, seizures, autonomic instability, and hypoventilation. the electroencephalographic (eeg) activity throughout the course of the disease has still not been well documented. we reviewed electroclinical data of patients with nmdar encephalitis to characterize their eeg and its clinical correlation. | 2015 | 26071995 |
| association of targeted multiplex pcr with resequencing microarray for the detection of multiple respiratory pathogens. | a large number of viral and bacterial organisms are responsible for community-acquired pneumonia (cap) which contributes to substantial burden on health management. a new resequencing microarray (rpm-ivdc1) associated with targeted multiplex pcr was recently developed and validated for multiple respiratory viruses detection and discrimination. in this study, we evaluated the capability of rpm-ivdc1 for simultaneous identification of multiple viral and bacterial organisms. the nasopharyngeal aspi ... | 2015 | 26074910 |
| [coexistence of pulmonary hydatid cyst and mycoplasma pneumoniae pnömonia in a child]. | hydatid cyst is a zoonotic disease and endemic in turkey. the disease can involve any organ. the most common involved organ is lung in childhood. hydatid cyst of lung may be asymptomatic or may be sometimes ruptured or infected. secondary bacterial infections associated with the hydatid cyst are well known. a previously not reported pediatric case of hydatid cyst with mycoplasma pneumoniae pneumonia is described in this report. it is emphasized that m. pneumoniae should be kept in mind as a caus ... | 2015 | 26081892 |
| [advantages and disadvantages of microbiological methods used in the diagnosis of mycoplasmapneumoniae infections in selected clinical situation]. | mycoplasma pneumoniae is one of the most common causes of community-acquired pneumonia in children and adults. correct and rapid laboratory diagnosis of m pneumoniae infections is important to introduce appropriate antibiotic treatment. diagnosis for m. pneumoniae usually relies on serological tests and/or molecular investigations. both methods have some advantages but also limitations. this paper presents advantages and disadvantages of microbiological methods used in m. pneumoniae infection an ... | 2015 | 26084074 |
| synergistic effects of mycoplasma pneumoniae infection and drug reaction on the development of atypical stevens-johnson syndrome in adults. | 2016 | 26084288 | |
| neurological complications of pcr-proven m. pneumoniae infections in children: prodromal illness duration may reflect pathogenetic mechanism. | the spectrum of neurologic disease attributable to mycoplasma pneumoniae in children is incompletely understood in part because of limitations of microbiologic diagnostic methods. our objective was to characterize the neurologic complications of m. pneumoniae in children using stringent diagnostic criteria. | 2015 | 26084846 |
| severe childhood guillain-barré syndrome associated with mycoplasma pneumoniae infection: a case series. | we report seven children with recent mycoplasma pneumoniae infection and severe guillain-barré syndrome (gbs) that presented to two european medical centres from 1992 to 2012. severe gbs was defined as the occurrence of respiratory failure, central nervous system (cns) involvement, or death. five children had gbs, one bickerstaff brain stem encephalitis (bbe), and one acute-onset chronic inflammatory demyelinating polyneuropathy (a-cidp). the five patients with severe gbs were derived from an or ... | 2015 | 26115201 |
| specificity and strain-typing capabilities of nanorod array-surface enhanced raman spectroscopy for mycoplasma pneumoniae detection. | mycoplasma pneumoniae is a cell wall-less bacterial pathogen of the human respiratory tract that accounts for > 20% of all community-acquired pneumonia (cap). at present the most effective means for detection and strain-typing is quantitative polymerase chain reaction (qpcr), which can exhibit excellent sensitivity and specificity but requires separate tests for detection and genotyping, lacks standardization between available tests and between labs, and has limited practicality for widespread, ... | 2015 | 26121242 |
| epidemiological comparison of three mycoplasma pneumoniae pneumonia epidemics in a single hospital over 10 years. | mycoplasma pneumoniae (mp) pneumonia epidemics have occurred in 3- to 4-year cycles in korea. we evaluated the epidemiologic characteristics of mp pneumonia in daejeon, korea, from 2003 to 2012. | 2015 | 26124847 |
| clinical features of post-infectious bronchiolitis obliterans in children undergoing long-term azithromycin treatment. | the aim of the present study was to outline any predisposing factors and clinical and radiological features of post-infectious bronchiolitis obliterans (pibo) in pediatric patients, and to determine the effect of long-term azithromycin treatment on these factors. in total, 16 cases of children with pibo were retrospectively reviewed. adenovirus and mycoplasma pneumoniae were the most common etiological agents (12/16) in the children with pibo. the patients presented with persistent dyspnea, a ch ... | 2015 | 26136991 |
| infection as a trigger for portal hypertension. | microbial infections are a relevant problem for patients with liver cirrhosis. different types of bacteria are responsible for different kinds of infections: escherichia coli and klebsiella pneumoniae are frequently observed in spontaneous bacterial peritonitis or urinary tract infections, and streptococcus pneumoniae and mycoplasma pneumoniae in pulmonary infections. mortality is up to 4-fold higher in infected patients with liver cirrhosis than in patients without infections. key messages: inf ... | 2015 | 26159275 |
| regional differences in prevalence of macrolide resistance among pediatric mycoplasma pneumoniae infections in hokkaido, japan. | recently, macrolide-resistant (mr) mycoplasma pneumonia appeared, and prevalence of macrolide resistance among m. pneumoniae infections varies by country. however, reports on regional differences in the prevalence of mr m. pneumonia within a country are scarce. in this study, 617 nasopharyngeal swab samples were collected from 617 pediatric patients, and dna of m. pneumoniae was identified in 95 samples. in 51 of the 95 m. pneumonia positive samples, we detected the presence of mutation a2063g m ... | 2016 | 26166502 |
| significance of lipopolysaccharide detection in children with pulmonary infections. | the present study aimed to observe the alterations of lipopolysaccharide (lps) and some other laboratory indexes in children suffering from pulmonary infections, and to investigate the condition of gram-negative bacterial infection. | 2015 | 26166651 |
| lung abscess caused by mycoplasma pneumoniae. | a 10-year-old boy with west syndrome was referred to hospital because of high fever and cough. chest x-ray and computed tomography showed consolidation with an abscess in the right upper lobe. laboratory data indicated cytokine storm. various antibacterial agents and additional corticosteroid were unable to control the hypercytokinemia, which was suppressed after cyclosporine a was started. the lung abscess remained, however, and right upper lobectomy was performed. culture from the abscess show ... | 2015 | 26177124 |
| activation of inflammasomes in dendritic cells and macrophages by mycoplasma salivarium. | interleukin-1β (il-1β) plays crucial roles in the pathogenesis of periodontal disease. it is produced after the processing of pro-il-1β by caspase-1, which is activated by the inflammasome-a multiprotein complex comprising nucleotide-binding domain leucine-rich repeat-containing receptor (nlr), the adaptor protein apoptosis-associated speck-like protein containing a caspase-recruitment domain (asc), and procaspase-1. mycoplasma salivarium preferentially inhabits the gingival sulcus and the incid ... | 2016 | 26177301 |
| isothermal detection of mycoplasma pneumoniae directly from respiratory clinical specimens. | mycoplasma pneumoniae is a leading cause of community-acquired pneumonia (cap) across patient populations of all ages. we have developed a loop-mediated isothermal amplification (lamp) assay that enables rapid, low-cost detection of m. pneumoniae from nucleic acid extracts and directly from various respiratory specimen types. the assay implements calcein to facilitate simple visual readout of positive results in approximately 1 h, making it ideal for use in primary care facilities and resource-p ... | 2015 | 26179304 |
| acute childhood encephalitis at 2 tertiary care children's hospitals in israel: etiology and clinical characteristics. | the clinical characteristics, pathogens, and outcome were analyzed to investigate the etiology of acute pediatric encephalitis in 2 tertiary pediatric medical centers in israel. | 2016 | 26181499 |
| diagnosing mycoplasma pneumoniae-induced rash and mucositis (mirm) in the emergency room. | 2015 | 26184002 | |
| reply to: "diagnosing mycoplasma pneumoniae-induced rash and mucositis (mirm) in the emergency room". | 2015 | 26184003 | |
| changes in levels of il-9, il-17, ifn-γ, dendritic cell numbers and tlr expression in peripheral blood in asthmatic children with mycoplasma pneumoniae infection. | mycoplasma pneumoniae (mp) infection in children with asthma resulted in a more severe allergic state compared with a non-mp infected group. the infection rate of children with asthma was higher than that of the other groups, suggesting that being asthmatic may be a predisposing factor for mp infection and that the infection itself is an important co-factor in the disease progression of asthma. the number of dendritic cells (dcs) and the expression of tlr2 and tlr4 were compared in 22 asthmatic ... | 2015 | 26191227 |
| macrolide-resistant mycoplasma pneumoniae, united states. | macrolide-resistant mycoplasma pneumoniae (mrmp) is highly prevalent in asia and is now being reported from europe. few data on mrmp are available in the united states. using genotypic and phenotypic methods, we detected high-level mrmp in 13.2% of 91 m. pneumoniae--positive specimens from 6 us locations. | 2015 | 26196107 |
| [mycoplasma pneumoniae-induced meningoencephalitis]. | in clinical practice, secondary infections of the central nervous system (cns) represent rare yet severe complications of their respective primary infections. in this case report, we describe a 22-year-old patient with a medical history of asthma bronchiale, who developed significant neurological deficits after a respiratory infection. the neurological symptoms progressed despite antibiotic therapy with vancomycin, ampicillin and ceftriaxone. the patient's cerebrospinal fluid and a cranial magne ... | 2015 | 26200044 |
| molecular epidemiology of mycoplasma pneumoniae: genotyping using single nucleotide polymorphisms and snapshot technology. | molecular typing of mycoplasma pneumoniae is an important tool for identifying grouped cases and investigating outbreaks. in the present study, we developed a new genotyping method based on single nucleotide polymorphisms (snps) selected from the whole-genome sequencing of eight m. pneumoniae strains, using the snapshot minisequencing assay. eight snps, localized in housekeeping genes, predicted lipoproteins, and adhesin p1 genes were selected for genotyping. these snps were evaluated on 140 m. ... | 2015 | 26202117 |
| development of a multilocus sequence typing scheme for molecular typing of mycoplasma pneumoniae. | mycoplasma pneumoniae is a major human respiratory pathogen causing both upper and lower respiratory disease in humans of all ages, and it can also result in other serious extrapulmonary sequelae. a multilocus sequence typing (mlst) scheme for m. pneumoniae was developed based on the sequences of eight housekeeping genes (ppa, pgm, gyrb, gmk, glya, atpa, arcc, and adk) and applied to 55 m. pneumoniae clinical isolates and the two type strains m129 and fh. a total of 12 sequence types (sts) resul ... | 2015 | 26202118 |
| pathogen transcriptional profile in nasopharyngeal aspirates of children with acute respiratory tract infection. | acute respiratory tract infections (ari) present a significant morbidity and pose a global health burden. patients are frequently treated with antibiotics although ari are most commonly caused by virus, strengthening the need for improved diagnostic methods. | 2015 | 26209405 |
| [a case of acute disseminated encephalomyelitis (adem) with an anti-galactocerebroside antibody]. | acute disseminated encephalomyelitis (adem) with an anti-galactocerebroside antibody is very rare. we report a case of 82-year-old man with adem associated with anti-galactocerebroside antibody in serum. he was admitted to our hospital after developing disturbed consciousness and respiratory failure. a cerebrospinal fluid examination disclosed an albuminocytologic dissociation and elevation of myelin basic protein. magnetic resonance images revealed lesions in the medulla oblongata, pons, midbra ... | 2015 | 26211664 |
| hepatitis associated with mycoplasma pneumoniae infection in korean children: a prospective study. | mycoplasma pneumoniae (mp) infection is a major cause of respiratory infection in school-aged children. extrapulmonary manifestations of mp infection are common, but liver involvement has been rarely reported. the aim of this study was to determine the clinical characteristics of mp-associated hepatitis. | 2015 | 26213549 |
| outbreak of mycoplasma pneumoniae-associated stevens-johnson syndrome. | stevens-johnson syndrome (sjs) is an uncommon, sporadic disease and outbreaks are rare. in november 2013, an outbreak of sjs was identified at children's hospital colorado. | 2015 | 26216320 |
| nonbullous erythema multiforme in hospitalized children: a 10-year survey. | nonbullous erythema multiforme (nbem) is an acute, immune-mediated, self-limiting skin disease with distinctive target lesions. its pathogenesis is unclear, but most cases are considered to be infection related or drug related. in adults, the main precipitating factor is infection. this study reviewed a 10-year experience with hospitalized children with nbem in a tertiary pediatric medical center in israel with a focus on precipitating factors. | 2015 | 26223537 |
| mycoplasma pneumoniae and chlamydophila pneumoniae: a comparative study in patients with nasal polyposis and healthy controls. | the role played by mycoplasma pneumoniae and chlamydophila pneumoniae in the pathogenesis of chronic rhinosinusitis with nasal polyps has been the object of ongoing debate. we used real-time polymerase chain reaction to investigate the prevalence of both microorganisms in the nasal tissue samples of patients and controls. | 2015 | 26223662 |
| community-acquired pneumonia: an overview. | community-acquired pneumonia is still a significant cause of morbidity and mortality and is often misdiagnosed and inappropriately treated. although it can be caused by a wide variety of micro-organisms, the pneumococcus, atypicals, such as mycoplasma pneumoniae and chlamydophila pneumoniae, staphylococcus aureus and certain gram-negative rods are the usual pathogens encountered. the site-of-care decision is critical in determining the site and type of care as well as the extent of diagnostic wo ... | 2015 | 26224210 |
| international mycoplasma pneumoniae typing study: interpretation of m. pneumoniae multilocus variable-number tandem-repeat analysis. | typing of mycoplasma pneumoniae by multiple-locus variable-number tandem repeat analysis (mlva) is increasingly in use. however, no specific internationally agreed guidance is available. thirty m. pneumoniae dna samples including serial dilutions of a type strain were sent to six international laboratories to perform mlva and results were compared. good correlation was observed, indicating that this methodology can be robustly performed in multiple sites. however, differences due to interpretati ... | 2015 | 26236493 |
| serum level of c-reactive protein is not a parameter to determine the difference between viral and atypical bacterial infections. | c-reactive protein (crp) is an acute-phase reactant that increases in the circulation in response to a variety of inflammatory stimuli. elevated levels in serum during several infectious diseases have been reported. in this study, a highly sensitive crp enzyme immunoassay was used to evaluate serum crp values in patients with viral and atypical bacterial infections. patients (n = 139) with different viral or atypical bacterial infections (systemic or respiratory) and healthy controls (n = 40) we ... | 2016 | 26241406 |
| acute postinfectious glomerulonephritis with a large number of crescents caused by mycoplasma pneumoniae. | mycoplasma pneumoniae-induced acute postinfectious glomerulonephritis has various pathological changes and relatively poor prognosis. it often occurs in children, barely in adults. currently, no clear treatment guidelines have been established for its treatment using glucocorticoid and immunosuppressive. in this study, we report an adult who admitted to our hospital due to fever and gross hematuria. the patient presented with nephritic syndrome and renal failure and confirmed to have m. pneumoni ... | 2015 | 26275270 |
| comparative genome analysis of mycoplasma pneumoniae. | mycoplasma pneumoniae is a common pathogen that causes upper and lower respiratory tract infections in people of all ages, responsible for up to 40% of community-acquired pneumonias. it also causes a wide array of extrapulmonary infections and autoimmune phenomena. phylogenetic studies of the organism have been generally restricted to specific genes or regions of the genome, because whole genome sequencing has been completed for only 4 strains. to better understand the physiology and pathogenici ... | 2015 | 26275904 |
| molecular detection and characterization of mycoplasma pneumoniae among patients hospitalized with community-acquired pneumonia in the united states. | background. mycoplasma pneumoniae is a common cause of community-acquired pneumonia (cap). the molecular characteristics of m pneumoniae detected in patients hospitalized with cap in the united states are poorly described. methods. we performed molecular characterization of m pneumoniae in nasopharyngeal/oropharyngeal swabs from children and adults hospitalized with cap in the centers for disease control and prevention etiology of pneumonia in the community (epic) study, including p1 typing, m ... | 2015 | 26284257 |
| lipschütz ulcers: should we rethink this? an analysis of 33 cases. | to describe the presentation and characteristics of patients with lipschütz ulcers (lu) and to evaluate the role of a standard protocol in the aetiological diagnosis. | 2016 | 26297242 |
| utility of serum ferritin and lactate dehydrogenase as surrogate markers for steroid therapy for mycoplasma pneumoniae pneumonia. | patients with severe mycoplasma pneumonia having very high serum interleukin-18 levels may require systemic corticosteroid treatment. however, we know of no laboratory markers that have been identified to assess the precise severity of mycoplasma pneumoniae pneumonia. thus, we investigated the usefulness of four clinical laboratory tests as severity indicators and surrogate markers for initiation of steroid therapy in these patients. | 2015 | 26298038 |
| diagnostic delay and amniotic membrane transplantation in a child with atypical stevens-johnson syndrome. | a 4-year-old boy presented with a 6-day history of severe non-limbic-sparing conjunctivitis. atypical stevens-johnson syndrome with a possible cause of mycoplasma pneumoniae was suspected as the precipitant of the clinical symptoms. the patient recovered with amniotic membrane transplantation and intravenous immunoglobulin therapy despite an initial delay in diagnosis. | 2015 | 26301401 |
| new insights in the outbreak pattern of mycoplasma pneumoniae. | since a well-documented incidence peak in 2011/12 in european countries, infections due to the cell wall-less bacterium mycoplasma pneumoniae have gained the increased attention of clinicians, microbiologists and health authorities. despite the mild or asymptomatic clinical course of most m. pneumoniae infections, the microorganism is responsible for severe interstitial pneumonia and extra-pulmonary complications. here, we report the time-dependence of 5545 notified cases of laboratory-confirmed ... | 2015 | 26319941 |
| comparative "-omics" in mycoplasma pneumoniae clinical isolates reveals key virulence factors. | the human respiratory tract pathogen m. pneumoniae is one of the best characterized minimal bacterium. until now, two main groups of clinical isolates of this bacterium have been described (types 1 and 2), differing in the sequence of the p1 adhesin gene. here, we have sequenced the genomes of 23 clinical isolates of m. pneumoniae. studying snps, non-synonymous mutations, indels and genome rearrangements of these 23 strains and 4 previously sequenced ones, has revealed new subclasses in the two ... | 2015 | 26335586 |
| emergence of macrolide-resistant mycoplasma pneumoniae in hong kong is linked to increasing macrolide resistance in multilocus variable-number tandem-repeat analysis type 4-5-7-2. | macrolide-resistant mycoplasma pneumoniae (mrmp) is rapidly emerging in asia, but information on the temporal relationship between the increase in macrolide resistance and changes in strain types is scarce. between 2011 and 2014, m. pneumoniae infection was diagnosed by pcr as part of routine care in a health care region in hong kong. testing was initiated by clinicians, mainly in patients with suspected m. pneumoniae pneumonia. specimens positive for m. pneumoniae were retrospectively investiga ... | 2015 | 26338857 |
| correction: sp-a preserves airway homeostasis during mycoplasma pneumoniae infection in mice. | 2015 | 26342104 | |
| overview of antimicrobial options for mycoplasma pneumoniae pneumonia: focus on macrolide resistance. | community-acquired pneumonia (cap) is a common infectious disease affecting children and adults of any age. mycoplasma pneumoniae has emerged as leading causative agent of cap in some region, and the abrupt increasing resistance to macrolide that widely used for management of m. pneumoniae has reached to the level that it often leads to treatment failures. | 2015 | 26365811 |
| comparison of molecular characteristics of mycoplasma pneumoniae specimens collected from the united states and china. | mycoplasma pneumoniae-positive clinical specimens obtained from the united states and china during the same period were studied for their molecular characteristics. we found much more diverse genotypes and a lower prevalence of macrolide resistance in the u.s. specimens. data from the study also showed an association of the resistance with certain genotypes. | 2015 | 26400785 |
| new epidemiological and clinical signatures of 18 pathogens from respiratory tract infections based on a 5-year study. | respiratory tract infections (rtis) are a heavy burden on society. however, due to the complex etiology of rtis, the clinical diagnosis, treatment, and prevention of these infections remain challenging, especially in developing countries. | 2015 | 26406339 |
| [clinical significance of mp-dna from endotracheal aspirates in diagnosis of mycoplasma pneumoniae pneumonia in children]. | to compare the detection rates of mycoplasma pneumoniae (mp) from nasopharyngeal aspirates (npa) and bronchoalveolar lavage fluid (balf) in children with pneumonia. | 2015 | 26412174 |
| the determinant of periodicity in mycoplasma pneumoniae incidence: an insight from mathematical modelling. | until the early 1990 s, incidences of mycoplasma pneumoniae (mp) infection showed three to five year epidemic cycles in multiple countries, however, the mechanism for the mp epidemic cycle has not been understood. here, we investigate the determinant of periodicity in mp incidence by employing a mathematical model describing mp transmission dynamics. three candidates for the determinant of periodicity were evaluated: school-term forcing, minor variance in the duration of immunity, and epidemiolo ... | 2015 | 26412506 |
| in silico approaches for the identification of virulence candidates amongst hypothetical proteins of mycoplasma pneumoniae 309. | mycoplasma pneumoniae type 2a strain 309 is a simplest known bacterium and is the primary cause of community acquired pneumonia in the children. it mainly causes severe atypical pneumonia as well as several other non-pulmonary manifestations such as neurological, hepatic, hemolytic anemia, cardiac diseases and polyarthritis. the size of m. pneumoniae genome (accession number: nc_016807.1) is relatively smaller as compared to other bacteria and contains 707 functional proteins, in which 204 are c ... | 2015 | 26414949 |
| role of atypical pathogens and the antibiotic prescription pattern in acute bronchitis: a multicenter study in korea. | the role of atypical bacteria and the effect of antibiotic treatments in acute bronchitis are still not clear. this study was conducted at 22 hospitals (17 primary care clinics and 5 university hospitals) in korea. outpatients (aged ≥ 18 yr) who had an acute illness with a new cough and sputum (≤ 30 days) were enrolled in 2013. multiplex real-time polymerase chain reaction (rt-pcr) was used to detect five atypical bacteria. a total of 435 patients were diagnosed as having acute bronchitis (vs. p ... | 2015 | 26425041 |
| acute generalized exanthematous pustulosis induced by mycoplasma pneumoniae infection. | 2016 | 26427049 | |
| in vitro subminimum inhibitory concentrations of macrolide antibiotics induce macrolide resistance in mycoplasma pneumoniae. | this study aims to investigate the inducing effect of subminimum inhibitory concentrations of macrolide antibiotics on mycoplasma pneumoniae (m. pneumoniae) resistance to drugs. | 2017 | 26435649 |
| epidemiological and clinical profiles of respiratory syncytial virus infection in hospitalized neonates in suzhou, china. | this study was designed to explore the epidemiological and clinical profiles of respiratory syncytial virus (rsv) infection in neonates from the suzhou area of china, taking into consideration how climate factors influence disease. | 2015 | 26470889 |
| acute necrotizing pancreatitis associated with mycoplasma pneumoniae infection in a child. | mycoplasma pneumoniae is responsible for approximately 20% to 30% of community-acquired pneumonia, and is well known for its diverse extrapulmonary manifestations. however, acute necrotizing pancreatits is an extremely rare extrapulmonary manifestation of m. pneumoniae infection. a 6-year-old girl was admitted due to abdominal pain, vomiting, fever, and confused mentality. acute necrotizing pancreatitis was diagnosed according to symptoms, laboratory test results, and abdominal computed tomograp ... | 2015 | 26473143 |
| [distribution of pathogenic microorganisms and its relationship with clinical features in children with community-acquired pneumonia]. | to study the distribution of pathogenic microorganisms in different genders, age groups and seasons in children with community-acquired pneumonia (cap) and the relationship between the distribution of pathogenic microorganisms and clinical features. | 2015 | 26483223 |
| pertussis accompanying recent mycoplasma infection in a 10-year-old girl. | recently, the incidence of pertussis has been increasing; however, reports on mixed infection of pertussis with other respiratory pathogens are rare in highly immunized populations. we report the case of a 10-year-old girl who presented with cough, post-tussive emesis, and fever. she was subsequently diagnosed with bronchopneumonia. although she had received five doses of diphtheria-tetanus-acellular pertussis vaccine, polymerase chain reaction of her nasopharyngeal aspirate confirmed bordetella ... | 2015 | 26483996 |
| rapid diagnosis of mycoplasma pneumoniae in children with pneumonia by an immuno-chromatographic antigen assay. | mycoplasma pneumoniae is a particularly important pathogen that causes community acquired pneumonia in children. in this study, a rapid test was developed to diagnose m. pneumoniae by using a colloidal gold-based immuno-chromatographic assay which targets a region of the p1 gene. 302 specimens were analyzed by the colloidal gold assay in parallel with real-time pcr. interestingly, the colloidal gold assay allowed m. pneumoniae identification, with a detection limit of 1 × 10(3) copies/ml. 76 sam ... | 2015 | 26486047 |
| [severe haemolysis caused by mycoplasma pneumoniae]. | mycoplasma pneumoniae is naturally resistant to betalactamase antibiotics but is sensitive to macrolides. occasionally, infections with m. pneumoniae can lead to severe anaemia due to its ability to cause haemolysis when cold agglutination occurs. increasing bacterial resistance to macrolid antibiotics is a growing concern worldwide. we present two cases where infection with m. pneumoniae caused severe haemolysis, one of which was macrolide-resistant. | 2015 | 26509456 |
| culture-independent detection and genotyping of mycoplasma pneumoniae in clinical specimens from beijing, china. | a duplex real-time pcr assay was designed for simultaneous detection and genotyping of mycoplasma pneumoniae (m. pneumoniae). the detection/typing performance of this duplex pcr method, targeting specific genes for m. pneumoniae type 1 (mpn 459) and type 2 (mpna 5864), was compared to that of the previously published mpp1 real-time pcr assay and the genotyping method for the adhesin p1 gene (mpn 141). a total of 1,344 throat swab specimens collected from patients in beijing, china were tested fo ... | 2015 | 26509651 |