Publications
| Title | Abstract | Year Filter | PMID(sorted ascending) Filter |
|---|
| comparative prognostic value of hpv16 e6 mrna compared with in situ hybridization for human oropharyngeal squamous carcinoma. | a significant proportion of oropharyngeal squamous cell carcinomas (oscc) are associated with the human papilloma virus (hpv), particularly hpv16. the optimal method for hpv determination on archival materials however, remains unclear. we compared a quantitative real-time polymerase chain reaction (qrt-pcr) assay for hpv16 mrna to a dna in situ hybridization (ish) method, and evaluated their significance for overall (os) and disease-free (dfs) survival. | 2009 | 19884544 |
| actual vs preferred sources of human papillomavirus information among black, white, and hispanic parents. | 2009 | 19884601 | |
| vaccinate or not? poep says physicians don't always suggest hpv vaccine. | even though the human papillomavirus vaccine has preventive benefits, a texas medical association survey shows texas physicians are slow to recommend it consistently to their young female patients. | 2009 | 19885756 |
| association of cystic neck metastases and human papillomavirus-positive oropharyngeal squamous cell carcinoma. | human papillomavirus is an established cause of oropharyngeal squamous cell carcinoma. similar to cervical cancer, these cancers are usually caused by high-risk human papillomavirus types 16 and 18 and are associated with high-risk sexual behaviors. human papillomavirus-associated oropharyngeal squamous cell carcinoma typically affects the palatine and lingual tonsils and frequently results in cystic neck metastases. the histopathology of this subset of head and neck squamous cell carcinoma is u ... | 2009 | 19886714 |
| erythema multiforme following vaccination for human papillomavirus. | erythema multiforme (em) is an acute self-limited immune-mediated reaction manifested by target skin lesions with mucous membrane involvement. the most common causes are infections and drugs. vaccinations have been reported as a triggering factor, and they may be a frequent cause of em in childhood. a 19-year-old female developed several target lesions of the hands and feet 10 days after the second dose of human papillomavirus (hpv) vaccine. clinico-histologically, a diagnosis of em minor was ma ... | 2010 | 19887766 |
| artistic: a randomised trial of human papillomavirus (hpv) testing in primary cervical screening. | primary cervical screening uses cytology to detect cancer precursor lesions [cervical intraepithelial neoplasia stage 3 or beyond (cin3+)]. human papillomavirus (hpv) testing could add sensitivity as an adjunct to cytology or as a first test, reserving cytology for hpv-positive women. this study addresses the questions: does the combination of cytology and hpv testing achieve a reduction in incident cin3+?; is hpv testing cost-effective in primary cervical screening?; is its use associated with ... | 2009 | 19891902 |
| human papillomavirus genotypes in invasive cervical cancer in jordan. | 2010 | 19892334 | |
| women >or=30 years of age with low grade squamous intraepithelial lesion (lsil) have low positivity rates when cotested for high-risk human papillomavirus: should we reconsider hpv triage for lsil in older women? | high-risk human papillomavirus (hr-hpv) testing for colposcopy triage of low grade squamous intraepithelial lesion (lsil) is not recommended because of high positive rates in young women. it remains unclear whether hr-hpv testing may be useful for triage of older women. we compiled hr-hpv data for women aged >or=30 years with lsil for the period march 1, 2006 to february 28, 2008. follow-up cervical biopsy information was collected for the period march 1, 2006 to august 15, 2008. we used the hyb ... | 2010 | 19894254 |
| cost-effectiveness analysis of human papillomavirus (hpv) vaccination in the netherlands: recent publication reinforces favorable cost-effectiveness despite misleading conclusion. | 2010 | 19896454 | |
| no evidence for a pathogenic role of human papillomavirus infection in ocular surface squamous neoplasia in germany. | the etiology of ocular surface squamous neoplasia is unknown. possible etiologic factors are physical and/or viral damage by human papillomavirus (hpv), especially in sub-saharian populations. this study focused on the presence of human papillomavirus in ocular surface squamous neoplasia in comparison to pterygia and normal conjunctiva. | 2009 | 19899994 |
| production of immunogenic human papillomavirus-16 major capsid protein derived virus like particles. | recombinant dna technology allows expression of the human papillomavirus (hpv) major capsid protein (l1) in heterologous expression systems and the recombinant protein self assembles to virus-like particles (vlp). we took up this study to produce recombinant hpv-16 l1 in yeast, establish the process of recombinant l1 derived vlp preparation and develop an elisa using vlp as the antigen for serological evaluation of anti hpv-16 l1 antibody status. | 2009 | 19901429 |
| infection of human papillomaviruses in cancers of different human organ sites. | clinico-epidemiological and molecular studies have established the casual link between human papillomavirus (hpv) infection and cervical cancer as also association of hpv infection with several other cancers. in india, cervical cancer is a leading cancer among women and almost all cases of cervical cancer show prevalence of high risk (hr)-hpv infection. hpv has been also detected in a significant proportion of oral, esophageal, anal, vaginal, vulvar, and penile cancer and in a small percentage o ... | 2009 | 19901431 |
| human papillomavirus infection (hpv) & screening strategies for cervical cancer. | the incidence of cervical cancer is declining slowly necessitating concerted and organized control measures. control through primary prevention has become a distinct reality though a prophylactic vaccine, which may take quite some time for its widespread use. thus control of cervical cancer through secondary preventive measures is the only viable solution now. while high quality cytology screening may not be feasible for widescale implementation in developing countries because of lack of necessa ... | 2009 | 19901432 |
| genotypes of the human papillomavirus: relevance to indian field trials of the vaccine. | highly effective hpv vaccines are likely to become available for use in india shortly. the availability and validation of the vaccines to prevent oncogenic hpv infection associated lesions from progressing to cancer has clearly offered a cost effective long-term strategy to reduce the cervical cancer burden, particularly for developing countries where effective screening programmes are not available. the enthusiasm for these new vaccines duly justified, are we in reality targeting the actual del ... | 2009 | 19901434 |
| human papillomavirus infection, cancer & therapy. | infection with human papillomaviruses (hpvs) is a major public health burden worldwide and is associated with a variety of epithelial lesions, including benign warts and several types of anogenital tumours, particularly cervical carcinoma. from available data it is clear that members of the hpv family are important human pathogens. prevention or elimination of these infections would not only benefit the numerous patients with benign lesions, but ultimately should reduce the incidence of cervical ... | 2009 | 19901437 |
| human papillomavirus vaccines: current issues & future. | cervical cancer is the leading cause of cancer mortality among women in worldwide. some 99 per cent of cervical cancer cases are linked to genital infection with human papillomaviruses (hpvs) comprised of approximately 15 oncogenic genital hpv types. most hpv infections resolve spontaneously. but, the remainder persist and may then progress to cervical cancer in some women. in high-resource countries, the best way to prevent cervical cancer is to implement organised gynaecological screening prog ... | 2009 | 19901444 |
| development of a soluble ptd-hpv18e7 fusion protein and its functional characterization in eukaryotic cells. | though accumulated evidence has demonstrated the transformation capacity of human papillomavirus (hpv) type 18 protein e7, the underlying mechanism is still arguable. developing a protein transduction domain (ptd)-linked e7 molecule is a suitable strategy for assessing the biological functions of the protein. in the present study, hpv18 e7 protein fused to an n-terminal ptd was expressed in the form of glutathione s-transferase fusion protein in escherichia coli with pgex-4t- 3 vector. after glu ... | 2009 | 19902124 |
| selective targeting of hpv-16 e6/e7 in cervical cancer cells with a potent oncolytic adenovirus and its enhanced effect with radiotherapy in vitro and vivo. | recent studies have shown that oncolytic adenovirus specifically targeted tumor cells while sparing normal cells. here, we report a novel e1a-mutant adenovirus (m6) with antisense hpv16 e6 e7 dna inserted into the deleted 6.7k/gp19k region of e3. the target effects of m6 on hpv16-positive cervical cancer cells were evaluated in vivo and in vitro. by using cytopathic effect (cpe) and viral replication assays, we verified m6 was competent to selectively replicate in cervical cancer cells in vitro. ... | 2010 | 19903581 |
| age-specific evaluation of primary human papillomavirus screening vs conventional cytology in a randomized setting. | human papillomavirus (hpv) dna testing has shown higher sensitivity than cytology for detecting cervical lesions, but it is uncertain whether the higher sensitivity is dependent on the age of the woman being screened. we compared the age-specific performance of primary hpv dna screening with that of conventional cytology screening in the setting of an organized population-based cervical cancer screening program in finland. | 2009 | 19903804 |
| women with hiv are more commonly infected with non-16 and -18 high-risk hpv types. | to review and summarize evidence from clinical, translational and epidemiologic studies which have examined the clinically relevant aspects of hpv type prevalence and cervical dysplasia in hiv-infected women. | 2010 | 19906410 |
| prevalence of human papillomavirus genotypes, and mucosal iga anti-viral responses in women with cervical ectopy. | data on the prevalence of different human papillomavirus (hpv) genotypes and the associated mucosal immune response in women with cervical ectopy are scarce. | 2010 | 19906557 |
| biomarkers in cervical screening: quantitative reverse transcriptase pcr analysis of p16ink4a expression. | molecular insights into the human papillomavirus (hpv)-induced cervical carcinogenesis led to the discovery of biomarkers for cervical disease. the detection of cellular proteins that are overexpressed by hpv-infected cells, such as tumor suppressor protein p16(ink4a), might play an important role in future cervical cancer screening strategies. p16(ink4a) immunostaining correlates with the severity of cytological and histological abnormalities, but shows some methodological shortcomings such as ... | 2010 | 19910796 |
| substituted tetrahydro-beta-carbolines as potential agents for the treatment of human papillomavirus infection. | the identification and optimization of a series of substituted tetrahydro-beta-carbolines with potent activity against human papillomavirus is described. structure-activity studies focused on the substitution pattern and chirality of the beta-carboline ring system are discussed. optimization of these parameters led to compounds with antiviral activities in the low nanomolar range. | 2010 | 19914830 |
| a 25-year analysis of veterans treated for tonsillar squamous cell carcinoma. | to determine the recurrence and survival outcome based on treatment date, type of treatment, stage of disease, and comorbidity and the recurrence and survival differences based on smoking status as a surrogate for human papillomavirus status in veterans treated for tonsillar squamous cell carcinoma (scc). | 2009 | 19917929 |
| formation of 8-nitroguanine, a nitrative dna lesion, in inflammation-related carcinogenesis and its significance. | chronic infection and inflammation contribute to a substantial part of environmental carcinogenesis. recently, it has been estimated that chronic inflammation accounts for approximately 25% of cancer cases. various infectious diseases and physical, chemical, and immunological factors participate in inflammation-related carcinogenesis. under inflammatory conditions, reactive oxygen and nitrogen species, which are generated from inflammatory and epithelial cells, may play an important role in carc ... | 2009 | 19921494 |
| eligibility and willingness of first-year students entering university to participate in a hpv vaccination catch-up program. | in france, human papillomavirus (hpv) vaccine is routinely recommended for 14-year-old girls; a catch-up vaccination should be offered to girls and women 15-23 years of age before the first time they have sex or within the first year after sexual activity begins. the aim of the present study was to examine the eligibility and willingness of first-year college students of toulouse university (france) to participate in a hpv vaccination catch-up program, and to estimate their knowledge of hpv vacc ... | 2010 | 19926199 |
| hpv vaccine protein l1 predicts disease outcome of high-risk hpv+ early squamous dysplastic lesions. | prediction of the clinical outcome of nonadvanced, early dysplastic lesions is one of the unresolved problems of cervical cancer screening programs. we examined the influence of human papillomavirus (hpv) l1 capsid protein detection in a randomized, prospective study of 187 high-risk hpv+ early dysplastic lesions during 36 to 46 months. the difference in the clinical outcome of the hpv l1- cases and the hpv l1+ cases was highly statistically significant (p < .0001) and independent of the classif ... | 2009 | 19926574 |
| high level protein expression in plants through the use of a novel autonomously replicating geminivirus shuttle vector. | we constructed a novel autonomously replicating gene expression shuttle vector, with the aim of developing a system for transiently expressing proteins at levels useful for commercial production of vaccines and other proteins in plants. the vector, pric, is based on the mild strain of the geminivirus bean yellow dwarf virus (beydv-m) and is replicationally released into plant cells from a recombinant agrobacterium tumefaciens ti plasmid. pric differs from most other geminivirus-based vectors in ... | 2010 | 19929900 |
| assessing knowledge of human papillomavirus and collecting data on sexual behavior: computer assisted telephone versus face to face interviews. | education campaigns seeking to raise awareness of human papillomavirus (hpv) and promoting hpv vaccination depend on accurate surveys of public awareness and knowledge of hpv and related sexual behavior. however, the most recent population-based studies have relied largely on computer-assisted telephone interviews (cati) as opposed to face to face interviews (ftfi). it is currently unknown how these survey modes differ, and in particular whether they attract similar demographics and therefore le ... | 2009 | 19930668 |
| prevalence of sexually transmitted infections among female adolescents aged 14 to 19 in the united states. | most young women initiate sexual activity during adolescence; risk for sexually transmitted infections (stis) accompanies this initiation. in this study we estimated the prevalence of the most common stis among a representative sample of female adolescents in the united states. | 2009 | 19933728 |
| update on quadrivalent human papillomavirus vaccination and pregnancy outcomes: is contraception advisable? | 2009 | 19935015 | |
| human papillomavirus prevalence and cytopathology correlation in young ugandan women using a low-cost liquid-based pap preparation. | screening for hpv-driven cervical dysplasia and neoplasia is a significant public health concern in the developing world. the purpose of this study was to use a manual, low-cost liquid-based pap preparation to determine hpv prevalence in hiv-positive and hiv-negative young women in kampala, uganda and to correlate cervical cytopathology with hpv-dna genotype. about 196 post-partum women aged 18-30 years underwent rapid hiv testing and pelvic examination. liquid-based cervical cytology samples we ... | 2010 | 19937939 |
| annual disease burden due to human papillomavirus 16 and 18 infections in finland. | apart from cancers of the lower female genital tract, human papillomaviruses (hpv) are associated with a large number of benign, premalignant and malignant lesions at different anatomic sites in both genders. malignant tumours and their precursors are usually attributed to the oncogenic (high-risk, hr) hpv types, whereas benign lesions (mostly papillomas) are ascribed to the low-risk (lr) hpv types, most notably hpv6 and hpv11. to date, the main interest has been focused on hr-hpv types and thei ... | 2009 | 19939209 |
| an analysis on the combination expression of hpv l1 capsid protein and p16ink4a in cervical lesions. | human papillomavirus (hpv) infection in cervix is the most important reason for cervical cancer, but only 2% cervical hpv infection will develop into cervical cancer. so how to identify patients at risk of progressive cervical lesions from those infected with hpv to avoid over treatment is a big issue in clinic. the aims of this study were to detect the expression of hpv l1 capsid protein and p16(ink4a) in cervical lesions and to investigate the combination expression of hpv l1 capsid protein an ... | 2010 | 19941368 |
| anal-rectal cytology: a review. | the incidence of invasive anal squamous cell carcinoma, a human papilloma virus (hpv) related cancer, is on the rise, especially in hiv positive men who have sex with men (msm). like cervical cancer, anal cancer is associated with precursor lesions detectable on exfoliative cytology as squamous intraepithelial lesions and on biopsy as intraepithelial neoplasia. anal-rectal cytology screening programs, similar to cervical cytology screening programs, have been developed in an effort to detect and ... | 2010 | 19941374 |
| currently approved prophylactic hpv vaccines. | cervarix and gardasil are two prophylactic hpv vaccines designed primarily for cervical cancer prevention. cervarix is effective against hpv-16, -18, -31, -33 and -45, the five most common cancer-causing types, including most causes of adenocarcinoma for which we cannot screen adequately. gardasil is effective against hpv-16, 18 and 31, three common squamous cell cancer-causing types. in addition, gardasil is effective against hpv-6 and -11, causes of genital warts and respiratory papillomatosis ... | 2009 | 19943762 |
| causes of oral cancer--an appraisal of controversies. | major risk factors for oral cancer are cigarette smoking and alcohol misuse. among asian populations, regular use of betel quid (with or without added tobacco) increases oral cancer risks. dentists should be aware of some emerging risk factors for oral, and particularly oropharyngeal cancer such as the role of the human papillomavirus infection (hpv). decreases in risk could be achieved by encouraging high fruit and vegetable consumption. some controversies related to the aetiology of this disea ... | 2009 | 19946320 |
| immunization for hiv-positive individuals. | this review summarizes recent literature addressing immunization in the setting of hiv infection, with a specific focus on emerging evidence that can guide the care of hiv-positive adults. | 2010 | 19949327 |
| enhancing the scope of conventional cervical cytology for detecting hpv infection. | cervical neoplasia is attributed to a persistent human papilloma virus infection. the pap smear being the mainstay of cervical cancer screening in low-resource settings, we studied the nonclassical features which might indicate hpv infection. these included abortive koilocytes, mild dyskeratosis, parakeratosis, mild nuclear hyperchromasia, bi/multinucleation, measles cells, and keratohyaline-like granules. two hundred and eight women with a satisfactory pap smear and a hybrid capture ii test wer ... | 2010 | 19950400 |
| persistent antibodies to hpv virus-like particles following natural infection are protective against subsequent cervicovaginal infection with related and unrelated hpv. | whether persistent human papillomavirus (hpv) igg antibodies following natural infection are protective against subsequent infection is unknown. in a cohort of 508 college women followed for 3 y, persistent seropositivity was defined as the presence of type-specific hpv virus-like particle (vlp) antibodies at > or = 2 consecutive visits 1 y apart. protection from incident infection with any hpv was conferred by persistent antibodies to hpv16 (p = 0.02), hpv31 (p < 0.001), hpv33 (p = 0.03), hpv35 ... | 2009 | 19951181 |
| adherence to cervical cancer screening guidelines for u.s. women aged 25-64: data from the 2005 health information national trends survey (hints). | although it is widely accepted that papanicolaou (pap) screening can reduce cervical cancer mortality, many women still do not maintain regular cervical cancer screenings. | 2009 | 19951209 |
| hpv vaccine acceptance among latina mothers by hpv status. | we investigated whether latina mothers who were and were not human papillomavirus (hpv) positive differed in their knowledge and acceptance of the hpv vaccine for their children. | 2009 | 19951213 |
| human papillomavirus knowledge and vaccine acceptability among a national sample of heterosexual men. | if approved for use in young males in the united states, prophylactic human papillomavirus (hpv) vaccine may reduce the incidence of hpv-related disease in vaccinated males and their sexual partners. we aimed to characterise heterosexual men's willingness to get hpv vaccine and identify correlates of vaccine acceptability. | 2010 | 19951936 |
| [effect of hpv16e6 on sensitivity of chemotherapy for cervical carcinoma in different p53 genotype cell lines]. | to investigate the effect of human papillomavirus types 16e6 on the sensitivity of chemotherapy for cervical carcinoma in different p53 genotype cell lines. | 2009 | 19952400 |
| interaction of immunological genes on chromosome 2q33 and ifng in susceptibility to cervical cancer. | cervical cancer is caused by persistent infection with human papillomavirus and genetic susceptibility factors may augment disease risk. the immune response consists of complex interactions and it was recently proposed that the association of combinations of genotypes at several genes should be examined. in support of this the combination cd28+17(tt)/ifng+874(aa) was shown to increase cervical cancer risk in a brazilian population (vb guzman et al. new approach reveals cd28 and ifng gene interac ... | 2010 | 19959217 |
| type-specific human papillomavirus oncogene messenger rna levels correlate with the severity of cervical neoplasia. | this study aimed to evaluate whether quantitation of high-risk human papillomavirus (hr-hpv) e6 messenger rna (mrna) can be a potential biomarker for detecting the severity of cervical lesions. hpv genotyping was performed using a modified my11/gp6+ pcr for hpv dna amplification, followed by hpv genotype-specific hybridization with on a gene chip. e6 type-specific pcr was used to validate multiple infections. quantitative real-time reverse transcriptase (qrt-pcr) and real-time pcr used to measur ... | 2010 | 19960432 |
| [preparation and identification of type specific and conformation dependent hpv16 l1 protein monoclonal antibody.]. | to generate type specific and conformation dependent monoclonal antibodies against human papillomavirus 16 major capsid l1 protein (hpv16 l1). | 2009 | 19961800 |
| appendix to: "pcr detection rates of high risk human papillomavirus dna in paired self-collected urine and cervical scrapes after laser co(2) conization for high-grade cervical intraepithelial neoplasia". | 2010 | 19969337 | |
| should boys receive the human papillomavirus vaccine? yes. | 2009 | 19969602 | |
| human papilloma virus and female lung adenocarcinoma. | lung cancer is the leading cause of cancer among women worldwide, and adenocarcinoma is the most common histological subtype among non-smoking women. previous studies showed that human papillomavirus (hpv) infection may relate to the tumorigenesis of pulmonary adenocarcinoma. women with anogenital malignancy have a higher risk of lung cancer, which raises the possibility of hpv transmission from the cervix to the lung. two postulated pathways are discussed in this work. first, hpv may infect the ... | 2009 | 19995646 |
| bowen's disease of the nail matrix presenting as melanonychia: detection of human papillomavirus type 56. | 2009 | 19997699 | |
| hpv in adolescents. making the wake-up call. | 2007 | 19998883 | |
| the role of human papillomavirus testing in cervical cancer screening. | 2009 | 19999172 | |
| [expression of gelatinases a and b and their endogenous regulators in immortal and transformed fibroblasts]. | matrix metalloproteinases (mmp) play a critical role in tumor invasion and metastasis. the aim of this study was to elucidate peculiarity of expression of gelatinases a and b (mmp-2 and mmp-9), membrane type mmp (mt1-mmp) and tissue inhibitor of mmp (timp-2) in immortal (if) and transformed fibroblasts (tf).the study was carried out using embryo rat fibroblasts, sequentially immortalized with the polyomavirus lt gene and transformed with the e7 gene of human papilloma virus (hpv-16). papilloma v ... | 2009 | 20000122 |
| integrating clinical, community, and policy perspectives on human papillomavirus vaccination. | infection with genital human papillomavirus (hpv) may cause anogenital cancers, oropharyngeal cancers, anogenital warts, and respiratory papillomas. two prophylactic vaccines (a bivalent and a quadrivalent vaccine) are now licensed and currently in use in a number of countries. both vaccines prevent infection with hpv-16 and hpv-18, which together cause approximately 70% of cervical cancers, and clinical trials have demonstrated 90%-100% efficacy in preventing precancerous cervical lesions attri ... | 2010 | 20001821 |
| an analysis of the human papilloma virus vaccine debate on myspace blogs. | the roll out of hpv immunization programs across the united states was hindered by controversy. we tracked the debate in the united states through myspace, then the most popular social networking site, in order to better understand the public's reaction to the vaccine. | 2010 | 20003922 |
| invited commentary: human papillomavirus infection and risk of cervical precancer--using the right methods to answer the right questions. | epidemiologists are well aware of the negative consequences of measurement error in exposure and outcome variables to their ability to detect putative causal associations. however, empirical proof that remedying the misclassification problem improves estimates of epidemiologic effect is seldom examined in detail. of all areas in cancer epidemiology, perhaps the best example of the consequences of misclassification and of the steps taken to circumvent them was the pursuit, beginning in the mid-19 ... | 2010 | 20007675 |
| human papillomavirus types 16 and 18 mrna levels and not dna levels may be associated with advancing stages of cervical cancer. | human papillomavirus (hpv) contributes to the development of cervical cancer. we hypothesize that hpv dna and messenger rna (mrna) levels may be associated with increasing stages of cervical cancer. | 2009 | 20009900 |
| naturally occurring systemic immune responses to hpv antigens do not predict regression of cin2/3. | essentially all squamous cervical cancers and their precursor lesions, high grade cervical intraepithelial neoplasia (cin2/3), are caused by persistent human papillomavirus (hpv) infection. however, not all cin2/3 lesions progress to cancer. in a brief, observational study window monitoring subjects with cin2/3 from protocol entry (biopsy diagnosis) to definitive therapy (cervical conization) at week 15, in a cohort of 50 subjects, we found that 26% of cin2/3 lesions associated with hpv16, the g ... | 2010 | 20012604 |
| the precancerous effect of emitted cooking oil fumes on precursor lesions of cervical cancer. | although cooking emission from high-temperature frying has been deemed a group 2a carcinogen by the international agency for research on cancer, little is known about its impact on cervical tumorigenesis. to investigate the precancerous consequence of cooking oil fumes on cervical intraepithelial neoplasm (cin), a community-based case-control study, which takes all known risk factors into consideration, was conducted in taiwan. from 2003 to 2008, in a pap smear screening and biopsy examination n ... | 2010 | 20013811 |
| atypical glandular cells (agc): thinprep imaging system (tis), manual screening (ms), and correlation with hybrid capture 2 (hc2) hpv dna testing. | the aim of the study was to determine if the thinprep imaging system (t1s) improves the positive predictive value (ppv) of atypical glandular cell (agc) diagnosis for identifying hpv-related squamous and/or glandular lesions over manual screening (ms), and if human papilloma virus (hpv)-dna testing improves the diagnostic yield. | 2010 | 20014311 |
| malignant transformation of a highly aggressive human papillomavirus type 11-associated recurrent respiratory papillomatosis. | the objective is to present an uncommon case of squamous cell carcinoma (scc) arising from extensive recurrent respiratory papillomatosis (rrp) involving the upper and lower airway and temporal bone. | 2010 | 20015762 |
| association of polymorphism in fcgr3a gene and progression of low-grade precursor lesions of cervical carcinoma. | polymorphisms in receptors of the constant part of antibodies (fcr) have been associated with susceptibility to disease and viral infections but have not been studied in cervical carcinogenesis. the distribution of the polymorphism v158f (rs396991) in fcgr3a in cervical smears was detected in a group of 84 women with stable or regressed low-grade squamous intraepithelial lesions (group i) and a group of 54 women with high-grade squamous intraepithelial lesions (hsil) (group ii). human papillomav ... | 2010 | 20018222 |
| prophylactic hpv vaccines: the finnish perspective. | finland is a country with a dual role in the human papillomavirus (hpv) field. finnish scientists have pioneered in hpv research and participated in international hpv vaccine trials, but officially finland is reluctant to implement hpv vaccines into its national vaccination program owing to the reasons discussed in this article. in contrast to other european countries, finnish authorities were reluctant to initiate the evaluation process for hpv vaccines after licensure. instead of prompt implem ... | 2010 | 20021305 |
| communication challenges of hpv vaccination. | the uk has introduced a national human papillomavirus (hpv) immunisation programme for girls aged 12-13 from autumn 2008. previous research has explored public understanding of the causes of cervical cancer and found little awareness of the role of hpv. | 2010 | 20022908 |
| the cyclin-dependent kinase inhibitor p21 is a crucial target for histone deacetylase 1 as a regulator of cellular proliferation. | histone deacetylases (hdacs) are chromatin-modifying enzymes that are involved in the regulation of proliferation, differentiation and development. hdac inhibitors induce cell cycle arrest, differentiation, or apoptosis in tumor cells and are therefore promising antitumor agents. numerous genes were found to be deregulated upon hdac inhibitor treatment; however, the relevant target enzymes are still unidentified. hdac1 is required for mouse development and unrestricted proliferation of embryonic ... | 2010 | 20028735 |
| ccl2 blockade augments cancer immunotherapy. | altering the immunosuppressive microenvironment that exists within a tumor will likely be necessary for cancer vaccines to trigger an effective antitumor response. monocyte chemoattractant proteins (such as ccl2) are produced by many tumors and have both direct and indirect immunoinhibitory effects. we hypothesized that ccl2 blockade would reduce immunosuppression and augment vaccine immunotherapy. anti-murine ccl2/ccl12 monoclonal antibodies were administered in three immunotherapy models: one ... | 2010 | 20028856 |
| recombination of human papillomavirus-16 and host dna in exfoliated cervical cells: a pilot study of l1 gene methylation and chromosomal integration as biomarkers of carcinogenic progression. | human papillomavirus-16 dna replicates in productive infections in circular form, but is found in most carcinomas integrated into the host cell dna. because this transition is essential for carcinogenesis, detailed research is desirable and may help to triage patients with abnormal pap smears. previous studies addressed the chromosomal integration of hpv-16 dna in biopsies of tumors by an indirect biomarker, methylation of the viral l1 gene and by reverse ligation polymerase chain reaction (rlip ... | 2010 | 20029805 |
| the basaloid cell is the best tissue marker for human papillomavirus in invasive penile squamous cell carcinoma: a study of 202 cases from paraguay. | human papillomavirus (hpv) has been reported in 12-82% of penile squamous cell carcinomas (scc). there is an association of the virus with basaloid and warty carcinomas but the reported prevalence is variable. the causes of these variations are not clear. they may be owing to geographic differences, the use of different techniques to detect hpv, the status of the original paraffin blocks, or to variable criteria in tumor classification. the aims of the study were to determine the prevalence of h ... | 2010 | 20035150 |
| [perspective of cervical cancer prevention and control in developing countries and areas]. | cervical cancer ranks the second common cancer in women, affecting women severely in developing countries. it is a critical issue to develop simple, rapid, accurate, safe, acceptable, and inexpensive screening tests which can be used in cervical cancer prevention programs in developing countries. due to the shortage of funding and qualified cytological professionals in most developing countries, who has been actively promoting visual inspection with acetic acid/iodine solution (via/vili) as the ... | 2010 | 20038301 |
| adverse events and quadrivalent human papillomavirus recombinant vaccine. | 2009 | 20040547 | |
| marketing and the hpv vaccine. | 2009 | 20040550 | |
| colposcopic characteristics of high-risk human papillomavirus-related cervical lesions. | because high-risk human papillomavirus (hrhpv) is the necessary factor in the development of high-grade cervical lesions, knowing the colposcopic differences between hrhpv-positive and hrhpv-negative lesions could be of value. we have evaluated whether there are colposcopic differences between lesions testing hrhpv-positive or hrhpv-negative. | 2010 | 20040836 |
| major clinical research advances in gynecologic cancer 2009. | in this review, we summarized nine major clinical advances in gynecology which occurred in 2009. for cervical cancer, the role of human papillomavirus (hpv) test as a screening test, the efficacy of hpv vaccine for middle-aged women, randomized controlled trial (rct) regarding concurrent chemoradiation using gemcitabine plus cisplatin, and the efficacy of pazopanib for metastatic or recurrent disease were chosen. for endometrial cancer, the necessity of systematic pelvic lymphadenectomy in early ... | 2009 | 20041096 |
| cost-effectiveness analysis of cervical cancer prevention based on a rapid human papillomavirus screening test in a high-risk region of china. | this study assessed the cost-effectiveness of a new, rapid human papillomavirus (hpv)-dna screening test for cervical cancer prevention in the high-risk region of shanxi, china. using micro-costing methods, we estimated the resources needed to implement preventive strategies using cervical cytology or hpv-dna testing, including the hybrid capture 2 (hc2) test (qiagen corp., gaithersburg, md) and the rapid hpv-dna carehpv test (qiagen). data were used in a previously published model and empirical ... | 2010 | 20049838 |
| [summary of the practice guideline 'prevention and early diagnosis of cervical cancer' of the dutch college of general practitioners]. | a persistent infection with human papillomavirus (hpv) underlies all cases of cervical cancer. hpv testing is repeated 6 months after initial pap smears 2 or 3a1. as vaccination against hpv is now included in the national immunisation programme of the netherlands, yearly cervical cancer morbidity and mortality rates are expected to be cut by half. after vaccination against hpv, women still need to participate in the cervical cancer screening programme. breastfeeding is no longer a contraindicati ... | 2009 | 20051149 |
| hpv prevalence in colombian women with cervical cancer: implications for vaccination in a developing country. | human papillomavirus (hpv) vaccines have been considered potentially cost-effective for the reduction of cervical cancer burden in developing countries; their effectiveness in a public health setting continues to be researched. we conducted an hpv prevalence survey among colombian women with invasive cancer. paraffin-embedded biopsies were obtained from one high-risk and one low-middle-risk regions. gp5+/gp6+ l1 primers, rlb assays, and e7 type specific pcr were used for hpv-dna detection. 217 c ... | 2009 | 20052389 |
| clinical and prognostic significance of human papillomavirus dna in the sperm or exfoliated cells of infertile patients and subjects with risk factors. | to evaluate human papillomavirus (hpv) sperm infection and its correlation with sperm parameters in infertile patients and subjects with risk factors. | 2010 | 20056213 |
| cost-effectiveness of human papillomavirus vaccination for prevention of cervical cancer in taiwan. | human papillomavirus (hpv) infection has been shown to be a major risk factor for cervical cancer. vaccines against hpv-16 and hpv-18 are highly effective in preventing type-specific hpv infections and related cervical lesions. there is, however, limited data available describing the health and economic impacts of hpv vaccination in taiwan. the objective of this study was to assess the cost-effectiveness of prophylactic hpv vaccination for the prevention of cervical cancer in taiwan. | 2010 | 20064239 |
| re: cost-effectiveness analysis of human papillomavirus vaccination in the netherlands. | 2010 | 20068192 | |
| the pdz domain binding motif (pbm) of human t-cell leukemia virus type 1 tax can be substituted by heterologous pbms from viral oncoproteins during t-cell transformation. | several tumor viruses, such as human t-cell leukemia virus (htlv), human papilloma virus (hpv), human adenovirus, have high-oncogenic and low-oncogenic subtypes, and such subtype-specific oncogenesis is associated with the pdz-domain binding motif (pbm) in their transforming proteins. htlv-1, the causative agent of adult t-cell leukemia, encodes tax1 with pbm as a transforming protein. the tax1 pbm was substituted with those from other oncoviruses, and the transforming activity was examined. tax ... | 2010 | 20069350 |
| immunomodulatory activity of a plant extract containing human papillomavirus 16-e7 protein in human monocyte-derived dendritic cells. | this study reports the immunomodulatory activity on human monocyte derived dendritic cells (mddcs) of a vaccine preparation shown to be effective against an hpv16-related tumour in an animal model. the vaccine is composed of extract from nicotiana benthamiana leaves containing hpv16 e7 protein expressed by a potato virus x-derived vector (nbpvx-e7). the effect of the extract was evaluated on mddc differentiation and maturation by monitoring the phenotypic expression of specific markers. the resu ... | 2009 | 20074460 |
| prevalence and genotype identification of human papillomavirus in women undergoing voluntary cervical cancer screening in molise, central italy. | we examined the prevalence of hr- and lr-hpv by linear array genotyping test in 299 women aged 18-63 years who consecutively visited molise region main hospitals for routine pap smear between february and august 2008. ninety women were positive for any hpv (30.1%), and 66 for any hr-hpv (22.1%). the most prevalent hr-hpv types were hpv 16 (22.2% of all women with hpv infection), hpv 53 (14.4%), and hpv 66 (14.4%). hpv infections increased from 15.8% in the 18-20 years group to 50.0% in the 21-23 ... | 2010 | 20080070 |
| [vaccination in paediatric oncohaematology]. | one of the most important elements in prophylaxis of infectious diseases of children, is vaccination. it is essential that vaccination should be used correctly and safely in children in immunosupression, including the patients suffering from haematological malignancies. oncological diseases as well as anticancer therapy disturb the functioning of the immunological system. particulary deep immunosupression is observed in patients who have undergone stem cell transplantation. for this reason most ... | 2009 | 20081279 |
| p634a4 and tap73 immunocytochemistry in liquid-based cervical cytology--potential biomarkers for diagnosis and progress prediction of cervical neoplasia. | p63 and p73 are two homologues of the important tumor suppressor gene p53. in this study, we investigated p63 and p73 expression by immunocytochemistry using antibodies for tap73 and p634a4 isoforms in 91 high-grade and 107 low-grade squamous intraepithelial lesions, 212 atypical squamous cells of undetermined significance, 9 squamous cell carcinomas and 63 normal samples from an asian screening population together with 47 hospital samples of carcinomas. there was significant correlation between ... | 2010 | 20081800 |
| common genetic variants and risk for hpv persistence and progression to cervical cancer. | hpv infrequently persists and progresses to cervical cancer. we examined host genetic factors hypothesized to play a role in determining which subset of individuals infected with oncogenic human papillomavirus (hpv) have persistent infection and further develop cervical pre-cancer/cancer compared to the majority of infected individuals who will clear infection.we evaluated 7140 tag single nucleotide polymorphisms (snps) from 305 candidate genes hypothesized to be involved in dna repair, viral in ... | 2010 | 20084279 |
| the cost effectiveness of a quadrivalent human papillomavirus vaccine (6/11/16/18) in hungary. | a transmission dynamic model was used to assess the epidemiological and economic impact of a quadrivalent human papillomavirus (hpv) (6/11/16/18) vaccine in preventing cervical cancer, cervical intraepithelial neoplasia grades 2 and 3 (cin 2/3), cin 1 and genital warts in hungary. | 2010 | 20085477 |
| inverted immature metaplasia of the uterine cervix. | 2010 | 20085521 | |
| [the statement of polish gynecological society experts about human papillomavirus (hpv) vaccine use to prevent cervical cancer (state of the art from the 19th of september 2009)]. | 2009 | 20088404 | |
| mechanisms of cell entry by human papillomaviruses: an overview. | as the primary etiological agents of cervical cancer, human papillomaviruses (hpvs) must deliver their genetic material into the nucleus of the target cell. the viral capsid has evolved to fulfil various roles that are critical to establish viral infection. the particle interacts with the cell surface via interaction of the major capsid protein, l1, with heparan sulfate proteoglycans. moreover, accumulating evidence suggests the involvement of a secondary receptor and a possible role for the min ... | 2010 | 20089191 |
| the risk of cin ii or greater in a one-year follow-up period in patients with asc-h interpreted with cytology. | to explore the risk of cin ii or greater in patients with cytologically interpreted atypical squamous cells, cannot exclude high grade squamous intraepithelial lesion (asc-h) in a one-year follow-up period. | 2010 | 20089347 |
| prevalence, distribution and correlates of endocervical human papillomavirus types in brazilian women. | we determined the prevalence, distribution and correlates of human papillomavirus (hpv) types in 386 mixed-income, sexually active women in são paulo, brazil. endocervical samples were tested for hpv dna with l1 primers my09 and my11; negative and indeterminate samples were retested using gp 5+/6+ consensus primers. hpv was detected in 35% of all women; high-risk/probable high-risk types in 20%; low-risk types in 7%; and an indeterminate type in 10%. twenty-five hpv types were found overall: 17 ... | 2010 | 20089995 |
| antibody detection against hpv16 e7 & gp96 fragments as biomarkers in cervical cancer patients. | cervical cancer is the second most frequent cancer among females worldwide, especially human papilloma viruses (hpv) types 16 and 18. in viral systems the identification of serological markers would facilitate the diagnosis of hpv infections and virus-related disease. the aim of the present investigation was to determine and search for serologic markers in cervical cancer patients associated with hpv. | 2009 | 20090101 |
| protein p 16ink4a expression in cervical intraepithelial neoplasia and invasive squamous cell carcinoma of uterine cervix. | the association of human papilloma virus (hpv) infection and cervical intraepithelial neoplasia (cin) is well recognized. interaction of hpv oncogenic proteins with cellular regulatory proteins leads to up regulation of p16 ink4a , a cdk inhibitor, which is a biomarker for hpv infection. we investigated p16 expression in cin and invasive squamous cell carcinoma (scc) which has not been reported in the indian population previously. | 2010 | 20090213 |
| relationship of atypical glandular cell cytology, age, and human papillomavirus detection to cervical and endometrial cancer risks. | to quantify the age-specific and reproductive organ-specific cancer risk after an atypical glandular cell (agc) cytologic interpretation in large clinic-based sample in which routine high-risk human papillomavirus (hpv) testing is conducted. | 2010 | 20093895 |
| surgical treatment of epidermodysplasia verruciformis. | epidermodysplasia verruciformis (ev) is a genodermatosis, characterized by human papilloma virus infection, with polymorphic and disseminated lesions that develop malignant transformation in approximately half of patients. | 2010 | 20100263 |
| association of hiv infection with distribution and viral load of hpv types in kenya: a survey with 820 female sex workers. | human papillomavirus (hpv) and hiv are each responsible for a considerable burden of disease. interactions between these infections pose substantial public health challenges, especially where hiv prevalence is high and hpv vaccine coverage low. | 2010 | 20102630 |
| [construction and immunogenicity evaluation of chimerical dna vaccine of human papillomavirus type 11]. | to construct chimerical dna vaccine plasmid of human papillomavirus type 11 (hpv11) l1-e7, and to evaluate its immunogenicity. | 2009 | 20104772 |
| human papilloma virus and cervical preinvasive disease. | cervical cancer lesions represent a major threat to the health of the women worldwide. human papillomavirus (hpv) is responsible for 99.7% of cervical cancer cases, the infectious etiology giving the possibility of preventing cervical cancer by vaccination. the most aggressive hpv types are 16 and 18, which cause about 70% of cases of invasive cancer. the vaccination is recommended to the girls aged 11-12. the diagnosis and the treatment of cervical preinvasive disease allow the doctor to preven ... | 2009 | 20108750 |
| [expression, purification and immunogenicity of human papillomavirus type 11 virus-like particles from escherichia coli]. | to produce human papillomavirus type 11 virus-like particles (hpv11 vlps) from escherichia coli and to investigate its immunogenicity and type cross neutralization nature. | 2009 | 20112683 |