Publications
| Title | Abstract | Year Filter | PMID(sorted ascending) Filter |
|---|
| genome-wide screening identifies phosphotransferase system permease bepa to be involved in enterococcus faecium endocarditis and biofilm formation. | enterococcus faecium is a common cause of nosocomial infections, of which infective endocarditis is associated with substantial mortality. in this study, we used a microarray-based transposon mapping (m-tram) approach to evaluate a rat endocarditis model and identified a gene, originally annotated as "frua" and renamed "bepa," putatively encoding a carbohydrate phosphotransferase system (pts) permease (biofilm and endocarditis-associated permease a [bepa]), as important in infective endocarditis ... | 2016 | 26984142 |
| complete genome sequence of enterococcus faecium commensal isolate e1002. | the emergence of vancomycin-resistant enterococci (vre) has been associated with an increase in multidrug-resistant nosocomial infections. here, we report the 2.614-mb genome sequence of the enterococcus faecium commensal isolate e1002, which will be instrumental in further understanding the determinants of the commensal and pathogenic lifestyle of e. faecium. | 2016 | 26988041 |
| food borne bacterial models for detection of benzo[a]pyrene-dna adducts formation using rapd-pcr. | random amplified polymorphic dna (rapd) pcr is a feasible method to evaluate genotoxin-induced dna damage and mutations. in this study, lactobacillus plantarum atcc 14917t, enterococcus faecium dsmz 20477t, escherichia coli pq37 and saccharomyces cerevisiae s441 were screened for dna genetic alterations by dna fingerprinting using m13 and la1 primers after treatment with three compounds forming covalent adducts with dna [benzo[a]pyrenediol epoxide (bpde), methyl methanesulfonate and 1,2,3,4-diep ... | 2016 | 26991971 |
| synthesis of e. faecium wall teichoic acid fragments. | the first synthesis of different enterococcus faecium wall teichoic acid (wta) fragments is presented. the structure of these major cell wall components was elucidated recently and it was shown that these glycerolphosphate (grop) based polymers are built up from -6-(galnac-α(1-3)-galnac-β(1-2)-grop)- repeating units. we assembled wta fragments up to three repeating units in length, in two series that differ in the stereochemistry of the glycerolphosphate moiety. the key galnac-galnac-grop syntho ... | 2016 | 26993744 |
| oritavancin activity tested against molecularly characterized staphylococci and enterococci displaying elevated linezolid mic results. | oritavancin (mic50/90, 0.03/0.06 to 0.12 μg/ml) had potent activity against linezolid-resistant staphylococci, as well as enterococcus faecalis and enterococcus faecium (oritavancin mic50/90, 0.015/0.12 μg/ml against both species). all linezolid-resistant isolates were inhibited by oritavancin at ≤0.12 μg/ml. these results confirmed the absence of cross-resistance between linezolid and oritavancin in staphylococci and enterococci. | 2016 | 27001823 |
| in vitro activity of a polyhexanide-betaine solution against high-risk clones of multidrug-resistant nosocomial pathogens. | to determine the in vitro activity of a polyhexanide-betaine solution against collection strains and multidrug-resistant (mdr) nosocomial isolates, including high-risk clones. | 2017 | 27004429 |
| thymidylate limitation potentiates cephalosporin activity toward enterococci via an exopolysaccharide-based mechanism. | multidrug resistant enterococci are major causes of nosocomial infections. prior therapy with cephalosporins increases the risk of developing an enterococcal infection due to the intrinsic resistance of enterococci to these antibiotics. while progress has been made toward understanding the genetic and biochemical mechanisms of cephalosporin resistance, available data indicate that as-yet-unidentified resistance factors must exist. here, we describe results of a screen to identify small molecules ... | 2016 | 27008338 |
| susceptibility of contemporary isolates to fosfomycin: a systematic review of the literature. | the aim of this review was to evaluate the susceptibility of contemporary gram-positive and gram-negative bacteria to fosfomycin. pubmed and scopus databases were systematically searched to identify studies published in print or electronically from january 2010 until june 2015. in total, 84 studies were selected. susceptibility to fosfomycin of staphylococcus aureus ranged between 33.2% and 100% (frequency=91.7%, 95% confidence interval 88.7-94.9%), of enterococcus spp. from 30% to 100% (enteroc ... | 2016 | 27013000 |
| draft genome sequence of the bacteriocin-producing strain enterococcus faecium m3k31, isolated from griffon vultures (gyps fulvus subsp. fulvus). | enterococcus faeciumm3k31 is a bacteriocinogenic lactic acid bacterium (lab) isolated from griffon vulture (gyps fulvussubsp.fulvus) feces. the draft genome sequence of this strain provides genetic data that support its biotechnological potential. | 2016 | 27013035 |
| community acquired enterococcal urinary tract infections and antibiotic resistance profile in north india. | urinary tract infections (utis) remain a major problem both in hospitalized and outdoor patients. multidrug-resistant enterococci are emerging as a major nosocomial pathogen with increasing frequency. however, the incidence of community-acquired enterococcal infections and species prevalent in india is not thoroughly investigated. | 2017 | 27013814 |
| molecular characterization of virulence genes in vancomycin-resistant and vancomycin-sensitive enterococci. | the aim of this study was to find out the correlation between presence of virulence (gelatinase [gel e], enterococcal surface protein [esp], cytolysin a [cyl a], hyaluronidase [hyl], and aggregation substance [asa1]) and vancomycin-resistant genes (van a and van b) in enterococci, with their phenotypic expression. | 2017 | 27013840 |
| prebiotics and age, but not probiotics affect the transformation of 2-amino-3-methyl-3h-imidazo[4,5-f]quinoline (iq) by fecal microbiota - an in vitro study. | heterocyclic aromatic amines (haas) are carcinogens which are formed in meat cooked using high-temperature methods. the human gastrointestinal (gi) microbiota plays a crucial role in maintaining health in humans of different ages, and especially in the elderly. however, the gi microbiota, whose metabolism and composition changes with age, may also be responsible for the activation of mutagenic substances reaching the colon with diet. probiotics and prebiotics are promising in terms of reducing t ... | 2016 | 27034248 |
| emergence of a daptomycin-non-susceptible enterococcus faecium strain that encodes mutations in dna repair genes after high-dose daptomycin therapy. | an increasing number of reports have documented the emergence of daptomycin-nonsusceptible enterococcus in patients during daptomycin therapy. even though several mechanisms for daptomycin-nonsusceptibility have been suggested, the potential genetic mutations which might contribute to the daptomycin-nonsusceptibility are not fully understood. | 2016 | 27036708 |
| influence of minimum inhibitory concentration in clinical outcomes of enterococcus faecium bacteremia treated with daptomycin: is it time to change the breakpoint? | daptomycin has become a front-line antibiotic for multidrug-resistant enterococcus faecium bloodstream infections (bsis). we previously showed that e. faecium strains with daptomycin minimum inhibitory concentrations (mics) in the higher end of susceptibility frequently harbor mutations associated with daptomycin resistance. we postulate that patients with e. faecium bsis exhibiting daptomycin mics of 3-4 µg/ml treated with daptomycin are more likely to have worse clinical outcomes than those ex ... | 2016 | 27045126 |
| beware of rim-enhancing lesions: a rare case of multiple scedosporium apiospermum and vancomycin-resistant enterococcus faecium intra-cranial abscesses. | the aim of this submission is to demonstrate the need for broad antimicrobial therapy, including empiric anti-fungal therapy, if rim-enhancing lesions are noted on cerebral imaging. | 2016 | 27045172 |
| involvement of the eukaryote-like kinase-phosphatase system and a protein that interacts with penicillin-binding protein 5 in emergence of cephalosporin resistance in cephalosporin-sensitive class a penicillin-binding protein mutants in enterococcus faecium. | the intrinsic resistance of enterococcus faecium to ceftriaxone and cefepime (here referred to as "cephalosporins") is reliant on the presence of class a penicillin-binding proteins (pbps) pbpf and pona. mutants lacking these pbps exhibit cephalosporin susceptibility that is reversible by exposure to penicillin and by selection on cephalosporin-containing medium. we selected two cephalosporin-resistant mutants (cro1 and cro2) of class a pbp-deficient e. faecium cv598. genome analysis revealed ch ... | 2016 | 27048803 |
| characteristics and outcomes of anti-infective de-escalation during health care-associated intra-abdominal infections. | de-escalation is strongly recommended for antibiotic stewardship. no studies have addressed this issue in the context of health care-associated intra-abdominal infections (hciai). we analyzed the factors that could interfere with this process and their clinical consequences in intensive care unit (icu) patients with hciai. | 2016 | 27052675 |
| validation of baking to control salmonella serovars in hamburger bun manufacturing, and evaluation of enterococcus faecium atcc 8459 and saccharomyces cerevisiae as nonpathogenic surrogate indicators. | this study was conducted to validate a simulated commercial baking process for hamburger buns to destroy salmonella serovars and to determine the appropriateness of using nonpathogenic surrogates (enterococcus faecium atcc 8459 or saccharomyces cerevisiae) for in-plant process validation studies. wheat flour was inoculated (∼6 log cfu/g) with three salmonella serovars (typhimurium, newport, or senftenberg 775w) or with e. faecium. dough was formed, proofed, and baked to mimic commercial manufact ... | 2016 | 27052857 |
| copper-coated textiles: armor against mdr nosocomial pathogens. | soft surfaces in the health-care setting harbor potentially pathogenic bacteria and fungi that can be transferred to patients and personnel. we evaluated the in vitro antimicrobial efficacy of two types of innovative copper-coated textiles against a variety of nosocomial multi-drug resistant (mdr) pathogens. five isolates each of mdr staphylococcus aureus, klebsiella pneumoniae, pseudomonas aeruginosa, acinetobacter baumannii and enterococcus faecium as well as three candida parapsilosis were te ... | 2016 | 27055400 |
| draft genome sequence of a vancomycin-resistant and vancomycin-dependent enterococcus faecium isolate. | vancomycin-resistant enterococci have emerged as major nosocomial pathogens worldwide. while antimicrobial pressure promotes nosocomial colonization with these enterococci, prolonged exposure to vancomycin may foster the transition from vancomycin resistance to vancomycin dependence. here, we report the draft genome sequence of a vancomycin-dependententerococcus faeciumisolate showing partial teicoplanin dependence. | 2016 | 27056211 |
| [role of bacteriobilia in postoperative complications]. | at present there is a controversy regarding the impact of positive bile cultures on morbidity and mortality rates, and on the incidence of readmissions in patients with biliar disease. the aim of this study was to evaluate the role of bacteriobilia in postoperatory infections, mortality or readmissions in these patients. | 2016 | 27062981 |
| paradoxical effect of polymyxin b: high drug exposure amplifies resistance in acinetobacter baumannii. | administering polymyxin antibiotics in a traditional fashion may be ineffective against gram-negative eskape (enterococcus faecium, staphylococcus aureus, klebsiella pneumoniae, acinetobacter baumannii, pseudomonas aeruginosa, and enterobacter species) pathogens. here, we explored increasing the dose intensity of polymyxin b against two strains of acinetobacter baumannii in the hollow-fiber infection model. the following dosage regimens were simulated for polymyxin b (t1/2 = 8 h): non-loading do ... | 2016 | 27067330 |
| antibiofilm peptides: potential as broad-spectrum agents. | the treatment of bacterial diseases is facing twin threats, with increasing bacterial antibiotic resistance and relatively few novel compounds or strategies under development or entering the clinic. bacteria frequently grow on surfaces as biofilm communities encased in a polymeric matrix. the biofilm mode of growth is associated with 65 to 80% of all clinical infections. it causes broad adaptive changes; biofilm bacteria are especially (10- to 1,000-fold) resistant to conventional antibiotics an ... | 2016 | 27068589 |
| genomic features and niche-adaptation of enterococcus faecium strains from korean soybean-fermented foods. | certain strains of enterococcus faecium contribute beneficially to human health and food fermentation. however, other e. faecium strains are opportunistic pathogens due to the acquisition of virulence factors and antibiotic resistance determinants. to characterize e. faecium from soybean fermentation, we sequenced the genomes of 10 e. faecium strains from korean soybean-fermented foods and analyzed their genomes by comparing them with 51 clinical and 52 non-clinical strains of different origins. ... | 2016 | 27070419 |
| comparison of clinical outcomes and risk factors in polymicrobial versus monomicrobial enterococcal bloodstream infections. | enterococcal bloodstream infections (ebsis) are frequently polymicrobial but scant data describe the outcomes and risk factors of polymicrobial ebsi. this study describes the outcomes and risk factors of polymicrobial versus monomicrobial ebsi. | 2016 | 27079241 |
| characterization of a genomic island harbouring a new vand allele from enterococcus faecium n15-508 isolated in canada. | 2016 | 27084917 | |
| oral pristinamycin for the treatment of resistant gram-positive infections in patients with cancer: evaluation of clinical outcomes. | pristinamycin has been used to treat a range of gram-positive infections, but reported experience in patients with malignancy is limited. this study aimed to evaluate the use of pristinamycin in patients with cancer at an australian centre. all patients commenced on oral pristinamycin therapy at the peter maccallum cancer centre between january 2005 and december 2014 were identified using the hospital pharmacy dispensing system. information on demographics, co-morbidities, cancer diagnosis, infe ... | 2016 | 27089829 |
| intestinal microbiota and oral administration of enterococcus faecium associated with the growth performance of new-born piglets. | the oral administration of enterococcus faecium ef1 to new-born suckling and weaning piglets along with their growth performances and intestinal microbiota was investigated in this study. twenty-four new-born piglets were initially divided into 2 groups. the probiotics group received 2 ml of 10% sterilised skimmed milk by oral gavage supplemented with 6×10(8) cfu/ml viable e. faecium ef1 at the first, the third and the fifth day after birth, while the control group received 2 ml of 10% sterilise ... | 2016 | 27089950 |
| β-lactam resistance mechanisms: gram-positive bacteria and mycobacterium tuberculosis. | the value of the β-lactam antibiotics for the control of bacterial infection has eroded with time. three gram-positive human pathogens that were once routinely susceptible to β-lactam chemotherapy-streptococcus pneumoniae, enterococcus faecium, and staphylococcus aureus-now are not. although a fourth bacterium, the acid-fast (but not gram-positive-staining) mycobacterium tuberculosis, has intrinsic resistance to earlier β-lactams, the emergence of strains of this bacterium resistant to virtually ... | 2016 | 27091943 |
| results of four-year rectal vancomycin-resistant enterococci surveillance in a pediatric hematology-oncology ward: from colonization to infection. | to investigate the clinical impact of vancomycin-resistant enterococci (vre) colonization in patients with hematologic malignancies and associated risk factors. | 2016 | 27094847 |
| extensively drug-resistant bacteria are an independent predictive factor of mortality in 130 patients with spontaneous bacterial peritonitis or spontaneous bacteremia. | to evaluate the epidemiology and outcomes of culture-positive spontaneous bacterial peritonitis (sbp) and spontaneous bacteremia (sb) in decompensated cirrhosis. | 2016 | 27099449 |
| investigation of hungarian mushrooms for antibacterial activity and synergistic effects with standard antibiotics against resistant bacterial strains. | this study aimed to screen the antibacterial activity of 160 extracts of 40 mushroom species, collected in hungary, against 11 standard bacterial strains and 9 clinical isolates. the further objective of this work was to evaluate the capacity of active fungal extracts to potentiate the action of antibiotics against resistant pathogens. disc-diffusion method was applied for screening of antibacterial activity of extracts. microdilution method was used to determine minimum inhibitory concentration ... | 2016 | 27100065 |
| effect of short-term probiotic enterococcus faecium sf68 dietary supplementation in overweight and obese cats without comorbidities. | obesity in cats is associated with metabolic abnormalities and increased susceptibility to diseases such as diabetes mellitus. studies in mouse models and human beings have shown that probiotics can reduce food intake, promote weight loss and improve metabolic profile. studies assessing the effects of probiotics on these same parameters are absent in cats. therefore, the aim of this study was to determine if probiotic enterococcus faecium strain sf68 dietary supplementation reduces food intake, ... | 2016 | 27110373 |
| vancomycin-resistant enterococci carriage in an acute irish hospital. | ireland has been shown to have the highest rate of vancomycin-resistant enterococci (vre) in cases of bacteraemia in europe, according to a report in 2014 from the european antimicrobial resistance surveillance system network. | 2016 | 27112046 |
| antibacterial activity of blue light against nosocomial wound pathogens growing planktonically and as mature biofilms. | the blue wavelengths within the visible light spectrum are intrinisically antimicrobial and can photodynamically inactivate the cells of a wide spectrum of bacteria (gram positive and negative) and fungi. furthermore, blue light is equally effective against both drug-sensitive and -resistant members of target species and is less detrimental to mammalian cells than is uv radiation. blue light is currently used for treating acnes vulgaris and helicobacter pylori infections; the utility for deconta ... | 2016 | 27129967 |
| screening municipal wastewater effluent and surface water used for drinking water production for the presence of ampicillin and vancomycin resistant enterococci. | the emergence of clinical enterococcal isolates that are resistant to both ampicillin and vancomycin is a cause of great concern, as therapeutic alternatives for the treatment of infections caused by such organisms are becoming limited. aquatic environments could play a role in the dissemination of antibiotic resistant enterococci. this study investigated the presence of ampicillin and vancomycin resistant enterococci in the treated effluent of six wastewater treatment plants (wwtps) and in surf ... | 2016 | 27134040 |
| a silenced vana gene cluster on a transferable plasmid caused an outbreak of vancomycin-variable enterococci. | we report an outbreak of vancomycin-variable vana(+) enterococci (vve) able to escape phenotypic detection by current guidelines and demonstrate the molecular mechanisms for in vivo switching into vancomycin resistance and horizontal spread of the vana cluster. forty-eight vana(+) enterococcus faecium isolates and one enterococcus faecalis isolate were analyzed for clonality with pulsed-field gel electrophoresis (pfge), and their vana gene cluster compositions were assessed by pcr and whole-geno ... | 2016 | 27139479 |
| virulence genes among enterococcus faecalis and enterococcus faecium isolated from coastal beaches and human and nonhuman sources in southern california and puerto rico. | most enterococcus faecalis and e. faecium are harmless to humans; however, strains harboring virulence genes, including esp, gele, cyla, asa1, and hyl, have been associated with human infections. e. faecalis and e. faecium are present in beach waters worldwide, yet little is known about their virulence potential. here, multiplex pcr was used to compare the distribution of virulence genes among e. faecalis and e. faecium isolated from beaches in southern california and puerto rico to isolates fro ... | 2016 | 27144029 |
| genome sequence of the multiantibiotic-resistant enterococcus faecium strain c68 and insights on the plrm23 colonization plasmid. | enterococcus faecium infections are a rising concern in hospital settings. vancomycin-resistant enterococci colonize the gastrointestinal tract and replace nonresistant strains, complicating the treatment of debilitated patients. here, we present a polished genome of the multiantibiotic-resistant strain c68, which was obtained as a clinical isolate and is a useful experimental strain. | 2016 | 27151808 |
| draft genome sequence of vancomycin-susceptible, ampicillin-intermediate enterococcus faecium strain d344rrf. | enterococcus faecium is an important nosocomial pathogen, causing a substantial health burden due to high resistance to antibiotics and its ability to colonize the gastrointestinal tract. here, we present the draft genome of vancomycin-susceptible, ampicillin-intermediate strain d344rrf, a rifampicin/fusidic acid-resistant and commonly used laboratory strain, which is useful in studying the transfer of antibiotic resistance. | 2016 | 27151809 |
| identification of subclinical transmission of vancomycin-resistant enterococcus within an intensive care unit in taiwan. | colonization, infection, and clonal dissemination of vancomycin-resistant enterococcus (vre) have been reported in the literature. we aimed to investigate the incidence rate of vre acquisition and route of transmission of vre within the medical intensive care unit (icu) to prove whether subclinical transmission occurs in medical icus. | 2016 | 27156242 |
| characterization and rapid control of a vancomycin-resistant enterococcus faecium (vref) outbreak in a renal transplant unit in spain: the environment matters. | to describe a clonal outbreak due to vancomycin-resistant enterococcus faecium (vref) in the nephrology and renal transplant unit of a tertiary teaching hospital in barcelona, spain, and to highlight how active patient and environment surveillance cultures, as well as prompt and directed intervention strategies, mainly environmental, helped to successfully bring it under control. | 2017 | 27156245 |
| effects of microbial enzymes on starch and hemicellulose degradation in total mixed ration silages. | this study investigated the association of enzyme-producing microbes and their enzymes with starch and hemicellulose degradation during fermentation of total mixed ration (tmr) silage. | 2017 | 27165015 |
| antibacterial potential and genetic profile of enterococcus faecium strains isolated from human normal flora. | enterococci have a widespread attendance in the circumference and belongs to the enteric commensal microbiota. most of them produce the antimicrobial compounds and have an inhibition effect on pathogenic microorganisms. the objective of this study was to characterize the enterococcal strains isolated from human normal flora and assess their antibacterial activity. enterococcal isolates were obtained from the feces of eighteen healthy humans. all enterococcal species were identified by biochemica ... | 2016 | 27165538 |
| detection of vancomycin resistance in enterococcus species isolated from clinical samples and feces of colonized patients by phenotypic and genotypic methods. | the aim of this study was to find out the clinical correlation between the presence of vancomycin-resistant genes (van a and van b) and their expression as detected by phenotypic tests in colonized patients and in clinical isolates. | 2017 | 27166038 |
| macrolide, glycopeptide resistance and virulence genes in enterococcus species isolates from dairy cattle. | the genus enterococcus is known to possess the capacity to acquire and disseminate antimicrobial resistant determinants alongside the ability to produce various virulence genes that enables it to establish infections. we assessed the prevalence and antibiogram profiles of enterococcus spp. in faecal samples of dairy cattle. faecal swab samples were collected from 400 dairy cattle from two commercial cattle farms in two rural communities in the eastern cape, south africa. confirmation of enteroco ... | 2016 | 27166215 |
| inactivation of salmonella, listeria monocytogenes and enterococcus faecium nrrl b-2354 in a selection of low moisture foods. | the aims of this study were to obtain data on survival and heat resistance of cocktails of salmonella, listeria monocytogenes and the surrogate enterococcus faecium (nrrl b-2354) in four low moisture foods (confectionery formulation, chicken meat powder, pet food and savoury seasoning) during storage before processing. inoculated samples were stored at 16°c and cell viability examined at day 0, 3, 7 and 21. at each time point, the heat resistance at 80°c was determined. the purpose was to determ ... | 2016 | 27174678 |
| co-infection with three linezolid-resistant enterococcus faecium st117 strain variants: what are we missing in diagnosis? | 2016 | 27179813 | |
| groel/es inhibitors as potential antibiotics. | we recently reported results from a high-throughput screening effort that identified 235 inhibitors of the escherichia coli groel/es chaperonin system [bioorg. med. chem. lett.2014, 24, 786]. as the groel/es chaperonin system is essential for growth under all conditions, we reasoned that targeting groel/es with small molecule inhibitors could be a viable antibacterial strategy. extending from our initial screen, we report here the antibacterial activities of 22 groel/es inhibitors against a pane ... | 2016 | 27184767 |
| real time application of whole genome sequencing for outbreak investigation - what is an achievable turnaround time? | whole genome sequencing (wgs) is increasingly employed in clinical settings, though few assessments of turnaround times (tat) have been performed in real-time. in this study, wgs was used to investigate an unfolding outbreak of vancomycin resistant enterococcus faecium (vre) among 3 patients in the icu of a tertiary care hospital. including overnight culturing, a tat of just 48.5 h for a comprehensive report was achievable using an illumina miseq benchtop sequencer. wgs revealed that isolates fr ... | 2016 | 27185645 |
| in vitro emergence of high persistence upon periodic aminoglycoside challenge in the eskape pathogens. | health care-associated infections present a major threat to modern medical care. six worrisome nosocomial pathogens-enterococcus faecium, staphylococcus aureus, klebsiella pneumoniae, acinetobacter baumannii, pseudomonas aeruginosa, and enterobacter spp.-are collectively referred to as the "eskape bugs." they are notorious for extensive multidrug resistance, yet persistence, or the phenotypic tolerance displayed by a variant subpopulation, remains underappreciated in these pathogens. importantly ... | 2016 | 27185802 |
| preliminary survey of local bacteriophages with lytic activity against multi-drug resistant bacteria. | bacteriophages (phages) represent a potential alternative for combating multi-drug resistant bacteria. because of their narrow host range and the ever emergence of novel pathogen variants the continued search for phages is a prerequisite for optimal treatment of bacterial infections. here we performed an ad hoc survey in the surroundings of a university hospital for the presence of phages with therapeutic potential. to this end, 16 aquatic samples of different origins and locations were tested s ... | 2016 | 27194637 |
| hybrid potential simulation of the acylation of enterococcus faecium l,d-transpeptidase by carbapenems. | the l,d-transpeptidases, ldts, catalyze peptidoglycan cross-linking in β-lactam-resistant mutant strains of several bacteria, including enterococcus faecium and mycobacterium tuberculosis. although unrelated to the essential d,d-transpeptidases, which are inactivated by the β-lactam antibiotics, they are nevertheless inhibited by the carbapenem antibiotics, making them potentially useful targets in the treatment of some important diseases. in this work, we have investigated the acylation mechani ... | 2016 | 27196382 |
| complete genome sequence of enterococcus faecium atcc 700221. | we report the complete genome sequence of a vancomycin-resistant isolate of enterococcus faecium derived from human feces. the genome comprises one chromosome of 2.9 mb and three plasmids. the strain harbors a plasmid-borne vana-type vancomycin resistance locus and is a member of multilocus sequencing type (mlst) cluster st-17. | 2016 | 27198022 |
| sequence-based characterization of tn5801-like genomic islands in tetracycline-resistant staphylococcus pseudintermedius and other gram-positive bacteria from humans and animals. | antibiotic resistance in pathogens is often associated with mobile genetic elements, such as genomic islands (gi) including integrative and conjugative elements (ices). these can transfer resistance genes within and between bacteria from humans and/or animals. the aim of this study was to investigate whether tn5801-like gis carrying the tetracycline resistance gene, tet(m), are common in staphylococcus pseudintermedius from pets, and to do an overall sequences-based characterization of tn5801-li ... | 2016 | 27199912 |
| bacterial adhesion to suture material in a contaminated wound model: comparison of monofilament, braided, and barbed sutures. | contaminated suture material plays an important role in the physiopathology of surgical site infections. recently, suture material has been developed characterized by barbs projecting from a monofilament base. claimed advantages for barbed sutures are a shortened wound closure time and reduced maximum wound tension. it has also been suggested that these sutures would be advantageous microbiologically. the aim of this study was to test the microbiological characteristics of the barbed quill in co ... | 2016 | 27208547 |
| clearance of infant vancomycin-resistant enterococcus faecium carriage after a neonatal inpatient outbreak. | a follow-up cohort study was undertaken to document clearance of fecal vancomycin-resistant enterococcus faecium carriage in 19 infants colonized during a hospital outbreak. by the conclusion of the 14-month study period, all participants had returned terminal negative fecal specimens, supporting the hypothesis that carriage is transient in this population. | 2016 | 27209094 |
| evaluation of technological properties of enterococcus faecium cect 8849, a strain isolated from human milk, for the dairy industry. | in this work, a variety of biochemical properties of enterococcus faecium cect 8849, which had been isolated from breast milk, were analyzed. its acidifying capacity and proteolytic activity were low but, in contrast, remarkable peptidase and esterase activities were observed. ethanol and 3-hydroxy-2-butanone were the most abundant volatile compounds found in experimental model cheese manufactured with e. faecium cect 8849. this strain inhibited the growth of several listeria monocytogenes and l ... | 2016 | 27216614 |
| growth behavior of e. coli, enterococcus and staphylococcus species in the presence and absence of sub-inhibitory antibiotic concentrations: consequences for interpretation of culture-based data. | culture-based approaches are used to monitor, e.g., drinking water or bathing water quality and to investigate species diversity and antibiotic resistance levels in environmental samples. for health risk assessment, it is important to know whether the growing cultures display the actual abundance of, e.g., clinically relevant antibiotic resistance phenotypes such as vancomycin-resistant enterococcus faecium/enterococcus faecalis (vre) or methicillin-resistant staphylococcus aureus. in addition, ... | 2016 | 27220972 |
| postneurosurgical central nervous system infection due to enterococcus faecalis successfully treated with intraventricular vancomycin. | infections from enterococcus faecalis and enterococcus faecium are uncommon in the post-neurosurgical intervention setting., [1, 2, 3, 4] intraventricular antibiotics are recommended when standard intravenous therapy fails. [5] here we present a case of post-neurosurgical ventriculitis, meningitis, and cerebritis in an oncology patient caused by refractory enterococcus faecalis successfully treated with intraventricular vancomycin. | 2016 | 27226704 |
| biofilm-forming capacity in biogenic amine-producing bacteria isolated from dairy products. | biofilms on the surface of food industry equipment are reservoirs of potentially food-contaminating bacteria-both spoilage and pathogenic. however, the capacity of biogenic amine (ba)-producers to form biofilms has remained largely unexamined. bas are low molecular weight, biologically active compounds that in food can reach concentrations high enough to be a toxicological hazard. fermented foods, especially some types of cheese, accumulate the highest ba concentrations of all. the present work ... | 2016 | 27242675 |
| synthetically tuning the 2-position of halogenated quinolines: optimizing antibacterial and biofilm eradication activities via alkylation and reductive amination pathways. | agents capable of eradicating bacterial biofilms are of great importance to human health as biofilm-associated infections are tolerant to our current antibiotic therapies. we have recently discovered that halogenated quinoline (hq) small molecules are: 1) capable of eradicating methicillin-resistant staphylococcus aureus (mrsa), methicillin-resistant staphylococcus epidermidis (mrse) and vancomycin-resistant enterococcus faecium (vre) biofilms, and 2) synthetic tuning of the 2-position of the hq ... | 2016 | 27245927 |
| molecular epidemiology of vancomycin resistant enterococci in a tertiary care hospital in saudi arabia. | vancomycin-resistant enterococci (vre) are a major cause of nosocomial infections with high mortality and morbidity. there is limited data on the molecular characterization of vre in saudi arabia. this study was carried out to investigate the premise that a shift in vre epidemiology is occurring in our setting. | 2016 | 27247096 |
| enterococcus xinjiangensis sp. nov., isolated from yogurt of xinjiang, china. | a gram-strain-positive bacterial strain 48(t) was isolated from traditional yogurt in xinjiang province, china. the bacterium was characterized by a polyphasic approach, including 16s rrna gene sequence analysis, polymerase α subunit (rpoa) gene sequence analysis, determination of dna g+c content, dna-dna hybridization with the type strain of enterococcus ratti and analysis of phenotypic features. strain 48(t) accounted for 96.1, 95.8, 95.8, and 95.7 % with enterococcus faecium cgmcc 1.2136(t), ... | 2016 | 27260143 |
| virulence traits and antibiotic resistance among enterococci isolated from dogs with periodontal disease. | periodontal disease - pd - is one of the most widespread diseases in dogs, but the role of this odontogenic infection in the dissemination of pathogenic bacteria present in the oral mucosa to other animals or pet owners is understudied. trying to unveil the putative pathogenicity of enterococci present in the gums of dogs diagnosed with pd, thirty-two animals were investigated during routine visits to a private veterinary clinic. seventy-one enterococci were recovered and characterized regarding ... | 2016 | 27260807 |
| the prevalence of aminoglycoside-modifying enzyme and virulence genes among enterococci with high-level aminoglycoside resistance in inner mongolia, china. | this study highlights the prevalence of aminoglycoside-modifying enzyme genes and virulence determinants among clinical enterococci with high-level aminoglycoside resistance in inner mongolia, china. screening for high-level aminoglycoside resistance against 117 enterococcal clinical isolates was performed using the agar-screening method. out of the 117 enterococcal isolates, 46 were selected for further detection and determination of the distribution of aminoglycoside-modifying enzyme-encoding ... | 2017 | 27268115 |
| substrate inhibition of vana by d-alanine reduces vancomycin resistance in a vanx-dependent manner. | the increasing resistance of clinical pathogens against the glycopeptide antibiotic vancomycin, a last-resort drug against infections with gram-positive pathogens, is a major problem in the nosocomial environment. vancomycin inhibits peptidoglycan synthesis by binding to the d-ala-d-ala terminal dipeptide moiety of the cell wall precursor lipid ii. plasmid-transferable resistance is conferred by modification of the terminal dipeptide into the vancomycin-insensitive variant d-ala-d-lac, which is ... | 2016 | 27270282 |
| mechanisms of antimicrobial resistance in eskape pathogens. | the eskape pathogens (enterococcus faecium, staphylococcus aureus, klebsiella pneumoniae, acinetobacter baumannii, pseudomonas aeruginosa, and enterobacter species) are the leading cause of nosocomial infections throughout the world. most of them are multidrug resistant isolates, which is one of the greatest challenges in clinical practice. multidrug resistance is amongst the top three threats to global public health and is usually caused by excessive drug usage or prescription, inappropriate us ... | 2016 | 27274985 |
| nutritional requirements in multiple auxotrophic lactic acid bacteria: genetic lesions affecting amino acid biosynthetic pathways in lactococcus lactis, enterococcus faecium, and pediococcus acidilactici. | in a study of genetic lesions responsible for amino acid requirements in multiple auxotrophic lactic acid bacteria, a systematic attempt was made to isolate mutants that could synthesize each of the amino acids required by the parental strains of lactococcus lactis, enterococcus faecium, and pediococcus acidilactici. after treatment with appropriate mutagens or, in some cases, spontaneously, such mutants could indeed be obtained with respect to many but not all essential amino acids. successful ... | 1992 | 27280812 |
| tigecycline antimicrobial activity tested against clinical bacteria from latin american medical centres: results from sentry antimicrobial surveillance program (2011-2014). | bacterial organisms (n = 13,494) were consecutively collected in 2011-2014 from 21 latin american medical centres (11 nations). antimicrobial susceptibility was determined by broth microdilution at a central laboratory. tigecycline was very active against gram-positive organisms, with mic50/90 values of 0.06/0.06 µg/ml for staphylococcus aureus (n = 2878), 0.06/0.12 µg/ml for coagulase-negative staphylococci (n = 880), 0.06/0.06 µg/ml for enterococci (n = 708) and ≤0.03/≤0.03-0.06 µg/ml for stre ... | 2016 | 27291285 |
| prevalence, antimicrobial resistance, and genotypic characterization of vancomycin-resistant enterococci in meat preparations. | a total of 160 samples of poultry (80), pork (40), and beef (40) preparations (red sausages, white sausages, hamburgers, meatballs, nuggets, minced meat, escalope, and crepes) were tested in northwestern spain to determine the prevalence of vancomycin-resistant enterococci (vre). vre were detected in 38 (23.8%) samples (37.5% of poultry, 15.0% of pork, and 5.0% of beef samples). one strain per food sample was further characterized. isolates were identified as enterococcus faecium (14 strains), e ... | 2016 | 27296421 |
| a novel way of treating multidrug-resistant enterococci. | daptomycin is the only antibiotic available with in vitro bactericidal activity against vancomycin-resistant enterococci (vre). its increased use has resulted in cases of decreased daptomycin efficacy. recent in vitro studies have shown effective use of beta (β)-lactam and daptomycin antibiotics, as a combination therapy, in the treatment of vre. we describe a case of effective treatment in a patient with vre infection using dual ampicillin and daptomycin therapy that shows bench-to-bedside appl ... | 2016 | 27298819 |
| molecular analysis of vancomycin-resistant enterococci isolated from regional hospitals in trinidad and tobago. | geographic spread of vancomycin-resistant enterococci (vre) clones in cities, countries, or even continents has been identified by molecular techniques. this study aimed at characterizing virulent genes and determining genetic relatedness of 45 vre isolates from trinidad and tobago using molecular tools, including polymerase chain reaction, pulsed-field gel electrophoresis (pfge), and random amplification polymorphic dna (rapd). the majority (84%) of the isolates were enterococcus faecium posses ... | 2016 | 27299153 |
| global emergence and dissemination of enterococci as nosocomial pathogens: attack of the clones? | enterococci are gram-positive bacteria that are found in plants, soil and as commensals of the gastrointestinal tract of humans, mammals, and insects. despite their commensal nature, they have also become globally important nosocomial pathogens. within the genus enterococcus, enterococcus faecium, and enterococcus faecalis are clinically most relevant. in this review, we will discuss how e. faecium and e. faecalis have evolved to become a globally disseminated nosocomial pathogen. e. faecium has ... | 2016 | 27303380 |
| simultaneous antibiofilm and antiviral activities of an engineered antimicrobial peptide during virus-bacterium coinfection. | antimicrobial-resistant infections are an urgent public health threat, and development of novel antimicrobial therapies has been painstakingly slow. polymicrobial infections are increasingly recognized as a significant source of severe disease and also contribute to reduced susceptibility to antimicrobials. chronic infections also are characterized by their ability to resist clearance, which is commonly linked to the development of biofilms that are notorious for antimicrobial resistance. the us ... | 2017 | 27303744 |
| revealing the combined effects of lactulose and probiotic enterococci on the swine faecal microbiota using 454 pyrosequencing. | demand for the development of non-antibiotic growth promoters in animal production has increased in recent years. this report compared the faecal microbiota of weaned piglets under the administration of a basal diet (con) or that containing prebiotic lactulose (lac), probiotic enterococcus faecium ncimb 11181 (pro) or their synbiotic combination (syn). at the phylum level, the firmicutes to bacteroidetes ratio increased in the treatment groups compared with the con group, and the lowest proporti ... | 2016 | 27305897 |
| comparison of two chromogenic media for the detection of vancomycin-resistant enterococcal carriage by nursing home residents. | we compared chromid vre and brilliance vre media for the detection of vancomycin-resistant enterococci (vre). using a panel of 28 enterococcal isolates, 10 vana enterococcus faecium and three vana enterococcus faecalis isolates grew as per manufacturers' instructions whilst growth of two vanc and eight vancomycin-susceptible enterococci was inhibited on both media. important differences were noted in the selectivity and chromogenic properties of the two media for vana enterococcus raffinosus and ... | 2016 | 27312688 |
| a novel approach to prove bacterial leakage of implant-abutment connections in vitro. | bacterial leakage from the implant-abutment-interface (iai) is suspected of contributing to the development of peri-implantitis. the aim of the study was to develop a straightforward test setup to evaluate the bacterial leakage of the iai of 2-piece implant systems under laboratory conditions. a test suspension of enterococcus faecium was injected into 7 implants (periotype rapid implants) prior to abutment fixation. the iai was covered by kanamycin aesculn azide agar (kaaa), which serves as an ... | 2016 | 27327361 |
| comprehensive characterization of ligand-induced plasticity changes in a dimeric enzyme. | an enzyme's inherent structural plasticity is frequently associated with substrate binding, yet detailed structural characterization of flexible proteins remains challenging. this study employs complementary biophysical methods to characterize the partially unfolded structure of substrate-free aac(6')-ii, an n-acetyltransferase of the gcn5-related n-acetyltransferase (gnat) superfamily implicated in conferring broad-spectrum aminoglycoside resistance on enterococcus faecium. the x-ray crystal st ... | 2016 | 27333541 |
| the crystal structure of the ligand-binding region of serine-glutamate repeat containing protein a (sgra) of enterococcus faecium reveals a new protein fold: functional characterization and insights into its adhesion function. | antimicrobial-resistant and hospital-adapted enterococcus faecium represents a clinical problem in immunocompromised patients in hospitals worldwide. understanding the molecular pathogenesis of e. faecium infections may provide novel therapies to treat or prevent infections. a potential target for novel treatment therapies is the serine-glutamate repeat containing protein a (sgra), which is a cell wall-anchored lpxtg surface protein implicated in binding to fibrinogen and nidogen. here, we repor ... | 2016 | 27334767 |
| antimicrobial activity against a global collection of skin and skin structure pathogens: results from the tigecycline evaluation and surveillance trial (t.e.s.t.), 2010-2014. | as part of the tigecycline evaluation and surveillance trial (t.e.s.t.) we report antimicrobial resistance among gram-positive and gram-negative isolates collected globally from integumentary sources between 2010 and 2014. | 2016 | 27343986 |
| characteristics of vancomycin-resistant enterococcus strains in the west balkans: a first report. | vancomycin-resistant enterococci are among the major causes of nosocomial infections and represent a growing problem in many european countries. among the most common enterococcal isolates, enterococcus faecium is considered to be the reservoir of vana and vanb-mediated resistance to glycopeptides. enterococci with vana-mediated resistance can transfer resistance genes to other enterococci and gram-positive bacteria. hence, monitoring and surveillance of vancomycin-resistant enterococci (vres) a ... | 2017 | 27351410 |
| in vitro spectrum of pexiganan activity; bactericidal action and resistance selection tested against pathogens with elevated mic values to topical agents. | pexiganan, in phase 3 clinical development for topical use, exhibited bactericidal activity in vitro against gram-positive and -negative isolates and was also shown to have a low potential for resistance development in broth serial passage experiments. susceptibility studies were performed against bacterial isolates (110 total from 2004 to 2013; primarily from skin and soft tissue infections) selected for elevated mic values (non-wildtype [wt] distributions) to bacitracin, polymyxin b, neomycin, ... | 2016 | 27352729 |
| sequential steps of daptomycin resistance in enterococcus faecium and reversion to hypersusceptibility through is-mediated inactivation of the liafsr operon. | to improve understanding of mechanisms of daptomycin resistance and to dissect the genetic basis of reversion to daptomycin hypersusceptibility in enterococcus faecium. | 2016 | 27353469 |
| pitfalls in the identification of enterococcus species and the detection of vana and vanb genes. | the aims were to assess the performance of vitek 2 in identifying enterococcal species and the implementation of genexpert(®) vana/vanb pcr for the detection of vancomycin-resistant enterococci (vre). gram-positive cocci from clinical and environmental specimens (n = 431) suspicious of being enterococci by conventional methods were evaluated by vitek 2. this system identified 296 enterococcus faecium, 87 enterococcus faecalis, 10 enterococcus villorum, 9 enterococcus gallinarum, 9 enterococcus d ... | 2016 | 27367648 |
| biosynthesis of zno nanoparticles using jacaranda mimosifolia flowers extract: synergistic antibacterial activity and molecular simulated facet specific adsorption studies. | the naturally occurring biomolecules present in the plant extracts have been identified to play an active role in the single step formation of nanoparticles with varied morphologies and sizes which is greener and environmentally benign. in the present work, spherical zinc oxide nanoparticles (zno nps) of 2-4nm size were synthesized using aqueous extract of fallen jacaranda mimosifolia flowers (jmfs), treated as waste. the microwave assisted synthesis was completed successfully within 5min. there ... | 2016 | 27380295 |
| bacterial population in intestines of litopenaeus vannamei fed different probiotics or probiotic supernatant. | the interactions of microbiota in the gut play an important role in promoting or maintaining the health of hosts. in this study, in order to investigate and compare the effects of dietary supplementation with lactobacillus pentosus hc-2 (hc-2), enterococcus faecium nrw-2, or the bacteria-free supernatant of a hc-2 culture on the bacterial composition of litopenaeus vannamei, illumina sequencing of the v1-v2 region of the 16s rrna gene was used. the results showed that unique species exclusively ... | 2016 | 27381338 |
| impact of the bacteriology of diabetic foot ulcers in limb loss. | infections in feet of patients with diabetes mellitus is common, complex and costly. the aim of this study to investigate the isolated microorganisms in infected diabetic foot ulcers, and the impact of these infectious agents in limb loss in a tertiary medical center in mexico city. we conducted a retrospective review in diabetic patients with infected foot ulcers from 1997 to 2014. diabetic foot was defined according to the world health organization (who), the bacteriology of wound cultures and ... | 2016 | 27388112 |
| aglycone isoflavones and exopolysaccharides produced by lactobacillus acidophilus in fermented soybean paste. | bioconversion of aglycone-formed isoflavones from glycoside-formed isoflavones by commercial lactic acid bacteria in fermented soybean paste was evaluated. enterococcus faecium kctc 13410 showed the most resistant capacity and lactobacillus acidophilus kctc 3925 had a sensitive susceptibility at a high nacl concentration (13.2%) in fermented soybean paste. among the 5 strains tested, lac. acidophilus kctc 3925 showed the highest relative ratio of aglycone-formed isoflavones to total isoflavones ... | 2016 | 27390728 |
| improvement of peroxyl radical scavenging bioassay based on bactericidal action of tert-butyl peroxyl radical. | an improved bioassay for measurement of peroxyl radical scavenging activity(1,2)) is described. the modifications included the use of (1) enterococcus faecium strain s, (2) 25% dimethyl sulfoxide, (3) l-ascorbic acid for the termination of the bactericidal reaction, and (4) the concentration of antioxidants that gives 75% of the log (colony forming unit/ml) of the control reaction (without methemoglobin or tert-butyl hydroperoxide), for the expression of antioxidant activity. | 1999 | 27393264 |
| polybrominated diphenyl ethers: structure determination and trends in antibacterial activity. | antibacterial-guided fractionation of the dictyoceratid sponges lamellodysidea sp. and two samples of dysidea granulosa yielded 14 polybrominated, diphenyl ethers including one new methoxy-containing compound (8). their structures were elucidated by interpretation of spectroscopic data of the natural product and their methoxy derivatives. most of the compounds showed strong antimicrobial activity with low- to sub-microgram ml(-1) minimum inhibitory concentrations against drug-susceptible and dru ... | 2016 | 27399938 |
| epidemiology and control of the first reported vancomycin-resistant enterococcus outbreak at a tertiary-care hospital in bangkok, thailand. | this retrospective study described the first reported vancomycin-resistant enterococci (vre) outbreak from june 2013 through january 2014 at a tertiary-care hospital in bangkok, thailand. after the index case was detected in an 18-bed medical intermediate care unit, a number of interventions was implemented, including targeted active surveillance for vre, strict contact precautions, enhanced standard precautions, dedicated units for vre cases, extensive cleaning of the environment and the restri ... | 2016 | 27405133 |
| bacteriocinogenic potential of enterococcus faecium isolated from wine. | a total of 145 lactic acid bacteria isolated from a variety of turkish red wines during malolactic fermentation were screened to find bacteriocin-producing strains. among them, 14 isolates of enterococcus faecium were identified to produce bacteriocins. pcr screening revealed that some isolates harbored enta and entb genes while some harbored enta, entb and entp genes. an isolate designated as ent. faecium h46 was selected to characterize its bacteriocins. the bacteriocins were purified to homog ... | 2016 | 27406790 |
| bacteriocinogenic bacteria isolated from raw goat milk and goat cheese produced in the center of méxico. | currently, there are few reports on the isolation of microorganisms from goat milk and goat cheese that have antibacterial activity. in particular, there are no reports on the isolation of microorganisms with antibacterial activity from these products in central mexico. our objective was to isolate bacteria, from goat products, that synthesized antimicrobial peptides with activity against a variety of clinically significant bacteria. we isolated and identified lactobacillus rhamnosus, l. plantar ... | 2016 | 27407294 |
| surveillance and control of antibiotic resistance in the mediterranean region. | antibiotic resistance is one of the most relevant problems in the healthcare: the growth of resistant microorganisms in healthcare settings is a worrisome threat, raising length to stay (los), morbidity and mortality in those patients. the importance of the antibiotic resistance and its spread around the world, gave rise to the activation of several surveillance systems, based especially on the collection of laboratory data to local or national level. the objective of this work is to carry out a ... | 2016 | 27413528 |
| evaluation of low-dose ultraviolet light c for reduction of select eskape pathogens in a canine skin and muscle model. | this study aimed at comparing the ability of low-dose uvc, 0.05% chlorhexidine, and combined uvc with 0.05% chlorhexidine to reduce colony-forming units (cfus) on select eskape pathogens (staphylococcus aureus, klebsiella pneumoniae, and enterococcus faecium) in a canine skin and muscle model. | 2016 | 27415773 |
| effect of extracted galactoglucomannan oligosaccharides from pine wood (pinus brutia) on salmonella typhimurium colonisation, growth performance and intestinal morphology in broiler chicks. | an in vitro and in vivo study was conducted to evaluate the fermentability of isolated galactoglucomannan oligosaccharides (ggms) and the influence of their feeding on shedding and colonisation of salmonella typhimurium, growth performance and intestinal morphology in broiler chicks. the in vitro data demonstrated that three probiotic lactic acid bacteria namely lactobacillus casei, l. plantarum and enterococcus faecium were able to ferment the extracted oligosaccharides and other tested sugars ... | 2016 | 27419477 |
| effect of dietary supplementation with a probiotic (enterococcus faecium) on production performance, excreta microflora, ammonia emission, and nutrient utilization in isa brown laying hens. | the ban on the use of antibiotics as growth promoters due to resistance issues has urged scientists to find alternatives to antibiotics. entercoccus faecium is one of the probiotics which have been used as an alternative to antibiotics in the livestock industry. this study was conducted to evaluate the effect of probiotic (enterococcus faecium dsm 7134) supplementation on production performance, feed intake, egg quality, excreta microflora, ammonia emission, and nutrient utilization in laying he ... | 2016 | 27422665 |
| vancomycin-resistant enterococci and bacterial community structure following a sewage spill into an aquatic environment. | sewage spills can release antibiotic-resistant bacteria into surface waters, contributing to environmental reservoirs and potentially impacting human health. vancomycin-resistant enterococci (vre) are nosocomial pathogens that have been detected in environmental habitats, including soil, water, and beach sands, as well as wildlife feces. however, vre harboring vana genes that confer high-level resistance have infrequently been found outside clinical settings in the united states. this study foun ... | 2016 | 27422829 |
| lactobacillus rhamnosus gg outcompetes enterococcus faecium via mucus-binding pili: evidence for a novel and heterospecific probiotic mechanism. | vancomycin-resistant enterococci (vre) have become a major nosocomial threat. enterococcus faecium is of special concern, as it can easily acquire new antibiotic resistances and is an excellent colonizer of the human intestinal tract. several clinical studies have explored the potential use of beneficial bacteria to weed out opportunistic pathogens. specifically, the widely studied lactobacillus rhamnosus strain gg has been applied successfully in the context of vre infections. here, we provide ... | 2016 | 27422834 |