Publications
| Title | Abstract | Year Filter | PMID(sorted ascending) Filter |
|---|
| human papillomavirus genotype specificity of hybrid capture 2 low-risk probe cocktail. | a genotyping study of 285 hybrid capture 2 low-risk probe cocktail-positive specimens showed cross-reactivity with several untargeted human papillomavirus genotypes. cross-reactivity was often clinically beneficial due to the detection of untargeted low-risk genotypes. a total of 8.4% of positive results, usually weak, were due to cross-reactivity with high-risk genotypes. establishment of a gray zone is recommended. | 2009 | 19494080 |
| laser capture microdissection of cervical human papillomavirus infections: copy number of the virus in cancerous and normal tissue and heterogeneous dna methylation. | research on the pathogenicity of human papillomaviruses (hpvs) during cervical carcinogenesis often relies on the study of homogenized tissue or cultured cells. this approach does not detect molecular heterogeneities within the infected tissue. it is desirable to understand molecular properties in specific histological contexts. we asked whether laser capture microdissection (lcm) of archival cervical tumors in combination with real-time polymerase chain reaction and bisulfite sequencing permits ... | 2009 | 19497607 |
| infectious disease: male circumcision for preventing hpv infection. | the role of male circumcision in reducing sexually transmitted infections is controversial. a series of recently published papers add to the growing body of evidence that male circumcision might reduce carriage of penile human papillomavirus (hpv). | 2009 | 19498404 |
| staurosporine induces apoptosis in human papillomavirus positive oral cancer cells at g2/m phase by disrupting mitochondrial membrane potential and modulation of cell cytoskeleton. | our study demonstrates that staurosporine (sts), a protein kinase inhibitor from streptomyces sp., induces apoptosis in human papillomavirus positive oral carcinoma cells (kb) in a dose dependent manner. growth inhibition studies revealed an ic(50) value of approximately 100 nm. sts induced marked nuclear fragmentation and inter-nucleosomal cleavage compared to untreated cells. it also caused dose dependent disruption of mitochondrial membrane potential and activation of caspase-3, indicating in ... | 2009 | 19502099 |
| hpv infection and p53 inactivation in pterygium. | our recent report indicated that tumor suppressor gene (p53) mutations and protein aberrant expression were detected in pterygium. inactivation of p53 by human papillomavirus (hpv) 16/18 e6 plays a crucial role in cervical tumorigenesis. in this study, we further speculate that p53 inactivation may be linked with hpv infection in pterygium pathogenesis. to investigate the involvement of hpv 16/18 e6 in p53 inactivation in pterygium, the association between hpv 16 or hpv 18 infection, the hpv e6 ... | 2009 | 19503739 |
| impact of human papillomavirus vaccination depends on effective vaccination strategy. | 2009 | 19507251 | |
| cell-mediated immune responses to human papillomavirus 16 e6 and e7 antigens as measured by interferon gamma enzyme-linked immunospot in women with cleared or persistent human papillomavirus infection. | cell-mediated immune responses have been thought to be important in the control of human papillomavirus (hpv) infections. we examined cell-mediated immune responses to hpv-16 e6 and e7 in the peripheral blood using interferon gamma (ifn-gamma) enzyme-linked immunospot assay (cellular technology ltd, cleveland, ohio) in women with hpv-16 infection who showed clearance and compared these women to women with hpv-16 persistence. women participating in a longitudinal study of cervical hpv were recrui ... | 2009 | 19509544 |
| patients with usual vulvar intraepithelial neoplasia-related vulvar cancer have an increased risk of cervical abnormalities. | vulvar squamous cell carcinoma (scc) originates the following two pathways, related to differentiated (d) vulvar intraepithelial neoplasia (vin) or to human papillomavirus (hpv)-related usual (u) vin. multicentric hpv infections (cervix, vagina and vulva) are common. we hypothesise that patients with a uvin-related vulvar scc more often have cervical high-grade squamous intraepithelial lesions (hsils) compared with women with dvin-related vulvar scc. | 2009 | 19513077 |
| adsorption of human papillomavirus 16 to live human sperm. | human papillomaviruses (hpvs) are a diverse group of viruses that infect the skin and mucosal tissues of humans. a high-risk subgroup of hpvs is associated with virtually all cases of cervical cancer [1]-[3]. high-risk hpvs are transmitted sexually; however, the exact mechanisms by which sexual contact promotes virus infection remain uncertain. to study this question we asked whether capsids of hpv type 16 (a high-risk hpv) specifically interact with sperm cells. we tested if purified hpv16 viri ... | 2009 | 19513123 |
| [detection of oncoprotein e7 hpv16 in the cancer and normal urinary bladder urothelium]. | oncoprotein e7 hpv16 was detected by immunohistochemical staining with specific polyclonal antiserum [fiedler et al., 2004] in 7 out of the 24 (29.2%) studied bladder cancer specimens. the result is in good agreement with the hypothesis that hpvs take part in the carcinogenesis of the urothelium. however, some of the observations made seem rather hard to be interpreted at present. the latter include the detection of e7 hpv16 in a small number of cancer cells in a few bladder cancer specimens bei ... | 2009 | 19514355 |
| cutaneotropic human beta-/gamma-papillomaviruses are rarely shared between family members. | several cutaneotropic human papillomavirus (hpv) types seem to be involved in the early onset of cutaneous squamous-cell carcinoma. to test the hypothesis that cutaneotropic hpv infections are facilitated because of close and frequent skin contact (for example, between child and mother), we examined hpv prevalence in hair follicle cells from 134 volunteers (1-89 years of age, median 42 years) from 13 families. we used a high-throughput hpv-typing approach with a sensitive beta-/gamma-cutaneous p ... | 2009 | 19516265 |
| expression of p16 in conjunctival intraepithelial neoplasia does not correlate with hpv-infection. | the aim of our study was to identify the frequency of expression of p16(ink4a) (cdkn2a) and hpv (human papilloma virus) in different grades of conjunctival intraepithelial neoplasia (cin).twelve specimens including cin i (2), ii (3), iii (5), and cin with beginning invasion (2), as well as 15 control specimens, were stained with antibodies against p16(ink4a) and mib1. the presence of hpv was examined by pcr.p16 as well as mib1 were significantly elevated in cin compared to control specimens (p<0 ... | 2008 | 19516893 |
| immunogenicity testing in human papillomavirus virus-like-particle vaccine trials. | 2009 | 19519255 | |
| [withdrawal of an advertising campaign to promote the quadrivalent human papilloma virus vaccine in spain]. | the inclusion of the quadrivalent human papilloma virus (hpv) vaccine in the schedule of the spanish national health system sparked the debate over gardasil, which was presented to the public as a "vaccine against cervical cancer". in this context, sanofi pasteur msd was sued for misleading advertising in the campaign "cuentaselo.org". although the complaint was not admitted, the lawsuit triggered five changes in the ownership of the web domain which, although backed by scientific societies, was ... | 2010 | 19523720 |
| "u" shape of age-specific prevalence of high-risk human papillomavirus infection in women attending hospitals in shanghai, china. | the purpose of the present study was to estimate the prevalence of high-risk human papillomavirus infection and the viral load in different age groups, to describe the distribution of human papillomavirus prevalence in women enrolled in two hospitals. | 2009 | 19525056 |
| elimination of high-risk human papillomavirus type hpv16 infection by 'praneem' polyherbal tablet in women with early cervical intraepithelial lesions. | 'praneem', a polyherbal formulation developed by us, has successfully completed phase ii efficacy study for treatment of abnormal vaginal discharge due to reproductive tract infections that act as co-factors for hpv persistence. in the present study we evaluated potential anti-hpv activity of praneem in women infected with high risk hpv type 16. | 2009 | 19526249 |
| prevalence of oncogenic human papillomavirus 16 and 18 in the palatine tonsils of the general adult population. | to determine whether there has been a demonstrable increase in the prevalence of human papillomavirus (hpv)-infected palatine tonsils corresponding to the increase in incidence of hpv-positive oropharyngeal squamous cell carcinoma (scc) over time. | 2009 | 19528402 |
| radiochemotherapy in locally advanced squamous cell carcinomas of the head and neck. | squamous cell carcinoma of the head and neck (scchn) is a common disease that develops in the upper aerodigestive epithelium. the most important risk factors are tobacco and alcohol consumption. there is also increasing evidence that human papillomavirus plays an important role in the cause of scchn. the complex anatomy, the vital functions of the upper aerodigestive tract and the close proximity to vital structures, explain that the goal of treatment is not only to improve survival outcomes, bu ... | 2009 | 19535232 |
| oncogenic activities of human papillomaviruses. | infectious etiologies for certain human cancers have long been suggested by epidemiological studies and studies with experimental animals. important support for this concept came from the discovery by harald zur hausen's group that human cervical carcinoma almost universally contains certain "high-risk" human papillomavirus (hpv) types. over the years, much has been learned about the carcinogenic activities of high-risk hpvs. these studies have revealed that two viral proteins, e6 and e7, that a ... | 2009 | 19540281 |
| human papilloma virus type and recurrence rate after surgical clearance of anal condylomata acuminata. | anal condylomata acuminata (aca) are caused by human papilloma virus (hpv) infection which is transmitted by close physical and sexual contact. the result of surgical treatment of aca has an overall success rate of 71% to 93%, with a recurrence rate between 4% and 29%. the aim of this study was to assess a possible association between hpv type and aca recurrence after surgical treatment. | 2009 | 19543141 |
| [the development and clinical application of papillomavirus genotyping by hpv dna suspension array the development and clinical application of papillomavirus genotyping by hpv dna suspension array]. | to develop a new platform for genotyping human papillomavirus(hpv) and to investigate its effect in clinical application. | 2008 | 19544658 |
| human papillomavirus test after conization in predicting residual disease in subsequent hysterectomy specimens. | to estimate the effectiveness of the human papillomavirus (hpv) test performed after conization in predicting residual disease in patients who subsequently underwent hysterectomy. | 2009 | 19546763 |
| human papillomavirus infection: a concise review of natural history. | persistent infection with oncogenic human papillomavirus (hpv), leading to precancerous lesions and potentially cervical cancer, is a serious health burden. the natural history of infection is one that enables the virus to remain immunoevasive within the cervical epithelium and persist for decades. many studies have provided important information on why some women clear infection and why others do not. the infectious process of hpv may be affected by many cofactors, adding to the complexity of d ... | 2009 | 19546771 |
| cervical cancers after human papillomavirus vaccination. | 2009 | 19546791 | |
| hpv16 tumor associated macrophages suppress antitumor t cell responses. | high-risk human papillomavirus (hpv) is the main etiologic factor for cervical cancer. the severity of hpv-associated cervical lesions has been correlated to the number of infiltrating macrophages. the objective of this work is to characterize the role of tumor-associated macrophages (tam) on the immune cellular response against the tumor. | 2009 | 19549768 |
| treatability by cryotherapy in a screen-and-treat strategy. | we estimated the percentage of women infected with human papillomavirus (hpv+) who cannot be immediately treated with cryotherapy. | 2009 | 19550216 |
| low rate of oral human papillomavirus (hpv) infection in women screened for cervical hpv infection in southern italy: a cross-sectional study of 140 immunocompetent subjects. | even though the natural history of cervical and oral human papillomavirus (hpv) infection has been investigated intensely, the possibility that hpv may infect both sites in the same subject is not well documented. this study investigated the frequency of concurrent oral and cervical hpv infection in southern italian women, in the light of some selected socio-behavioral variables. one hundred forty women (mean age: 36 years), with known cervical hpv status, were analyzed for oral hpv. age, smokin ... | 2009 | 19551817 |
| brd4 regulation of papillomavirus protein e2 stability. | the papillomavirus (pv) e2 protein is an important regulator of the viral life cycle. it has diverse roles in viral transcription, dna replication, and genome maintenance. our laboratory has previously identified the cellular bromodomain protein brd4 as a key interacting partner of e2. brd4 mediates the transcriptional activation function of e2 and plays an important role in viral genome maintenance in dividing cells. e2 interacts with the c-terminal domain (ctd) of brd4, and the ctd functions i ... | 2009 | 19553317 |
| detection and genotyping of human papillomavirus in self-obtained cervicovaginal samples by using the fta cartridge: new possibilities for cervical cancer screening. | this study assesses human papillomavirus (hpv) detection and genotyping in self-sampled genital smears applied to an indicating fta elute cartridge (fta cartridge). the study group consisted of 96 women, divided into two sample sets. all samples were analyzed by the hpv spf(10)-line blot 25. set 1 consisted of 45 women attending the gynecologist; all obtained a self-sampled cervicovaginal smear, which was applied to an fta cartridge. hpv results were compared to a cervical smear (liquid based) t ... | 2009 | 19553570 |
| establishing an anal dysplasia clinic for hiv-infected men: initial experience. | anal dysplasia caused by human papillomavirus (hpv) infection is common in the hiv-infected population and is a precursor to squamous cell carcinoma of the anus (scca). herein, we describe our initial experience in assessing the frequency and severity of anal intraepithelial neoplasia (ain) in a newly formed anal dysplasia clinic in seattle. during a 7-month period, 150 hiv-positive men were evaluated by digital rectal examination and high-resolution anoscopy (hra). forty-seven patients of the 1 ... | 2009 | 19554736 |
| role of human papillomavirus and its detection in potentially malignant and malignant head and neck lesions: updated review. | head and neck malignancies are characterized by a multiphasic and multifactorial etiopathogenesis. tobacco and alcohol consumption are the most common risk factors for head and neck malignancy. other factors, including dna viruses, especially human papilloma virus (hpv), may also play a role in the initiation or development of these lesions. the pathways of hpv transmission in the head and neck mucosal lesions include oral-genital contact, more than one sexual partner and perinatal transmission ... | 2009 | 19555477 |
| serological response to an hpv16 e7 based therapeutic vaccine in women with high-grade cervical dysplasia. | infection with oncogenic human papillomaviruses has been linked to the development of cervical neoplasia and cancer. the exclusive expression of e7, a viral oncogene, in infected cells makes this protein an ideal target for immunotherapy. we recently reported on the results of a trial in women with cervical carcinoma-in-situ using hspe7, a protein vaccine consisting of full length hpv16 e7 linked to a heat shock protein from m. bovis. the stimulating effects of hspe7 on specific cytotoxic t lymp ... | 2010 | 19555999 |
| twenty-year trends in the incidence and prevalence of diagnosed anogenital warts in canada. | a vaccine has recently been licensed in many countries that protects against the human papillomavirus types 6, 11, 16, and 18. types 6 and 11 account for approximately 90% of anogenital warts (agws). we describe the 20-year trends in the incidence and prevalence of agws in manitoba, canada. | 2009 | 19556932 |
| merck aims for male gardasil. | 2009 | 19557939 | |
| proliferative defects in dyskeratosis congenita skin keratinocytes are corrected by expression of the telomerase reverse transcriptase, tert, or by activation of endogenous telomerase through expression of papillomavirus e6/e7 or the telomerase rna component, terc. | dyskeratosis congenita (dc) is characterized by the triad of reticulate skin pigmentation, nail dystrophy and leukoplakia. epidermal atrophy, hair growth defects, bone marrow failure and increased risk of cancer are also common in dc patients. dc is caused by mutations in genes encoding for telomerase complex factors. although there is an association of epidermal abnormalities with dc, epidermal cells from dc donors have not been previously characterized. we have isolated skin keratinocytes from ... | 2010 | 19558498 |
| [a case-control study on the association of rfc-1 polymorphism and cervical cancer]. | to evaluate the possible association between rfc-1 polymorphism and cervix carcinoma, as well as the interaction between polymorphism and human papilloma virus16 (hpv16). | 2009 | 19565885 |
| use of quantum dots to detect human papillomavirus in oral squamous cell carcinoma. | to examine the association of oral squamous cell carcinoma with human papillomavirus (hpv) using quantum dots (qd) in situ hybridization (ish). | 2009 | 19566742 |
| cost-effectiveness analysis of human papillomavirus-vaccination programs to prevent cervical cancer in austria. | the study predicts long-term cervical cancer related population health and economic effects of introducing the hpv-vaccination for 12-year-old girls (and boys) in addition to current screening compared with screening only. | 2009 | 19567244 |
| the etiologic role of hpv in vulvar squamous cell carcinoma fine tuned. | high-risk human papilloma virus (hpv) plays a role in the development of a subset of vulvar squamous cell carcinomas. uncertainty exists about the true impact of hpv in this tumor type because conflicting reports have been published with diverging prevalence rates. this study was done to fine tune the role of high-risk hpv infection in vulvar squamous cell carcinoma development in relation to clinical prognosis. | 2009 | 19567503 |
| expression of heat shock protein 60 kda is upregulated in cervical cancer. | cervical cancer caused by the human papilloma virus (hpv) continues to be the cause of yearly death among women. however, it is a curable disease when diagnosed at an early stage. recently, several researches have reported that heat shock protein (hsp) 60, a chaperone protein of molecular weight of 60 kda, is involved in carcinogenesis and apoptosis. in order to evaluate the prognostic significance of hsp60 in cervical cancer, we examined differences in the hsp60 expression between cervical canc ... | 2009 | 19568603 |
| [clinical analysis of 35 cases of vulvar intraepithelial neoplasia grade iii]. | to evaluate the etiology, clinicopathological characteristics, treatment and prognosis of viniii. | 2009 | 19570437 |
| [analysis of diagnosis and treatment of vaginal intraepithelial neoplasia and correlation to cervical intraepithelial neoplasia]. | to investigate the diagnosis and therapy of vaginal intraepithelial neoplasia (vain) and correlation to cervical intraepithelial neoplasia (cin). | 2009 | 19570439 |
| cost-effectiveness analysis of human papillomavirus vaccination in the netherlands. | in the netherlands, low cervical cancer incidence and mortality rates might limit the cost-effectiveness of vaccination against the human papillomavirus (hpv). we examined the effect on cervical cancer incidence and mortality of adding hpv vaccination to the current dutch cervical cancer screening situation and calculated the cost-effectiveness. | 2009 | 19571256 |
| transoral laser microsurgery (tlm) +/- adjuvant therapy for advanced stage oropharyngeal cancer: outcomes and prognostic factors. | document survival, prognostic variables, and functional outcomes of patients with ajcc stage iii or iv oropharyngeal cancer, treated with transoral laser microsurgery (tlm) +/- adjuvant therapy. | 2009 | 19572271 |
| screening for human papillomavirus: is urine useful? | persistent infection with high-risk human papillomavirus (hr-hpv 16, 18, 31, 33, and 45) is the main risk factor for developing malignant genital lesions. screening methods and follow-up schedules for cervical cancer are well known. a golden standard to screen and monitor men does not exist yet, because hpv-related, life threatening malignancies in men are rare. the importance of male hpv screening lies mainly in hpv vaccination. young females are the target group for hpv, but men are considered ... | 2009 | 19574669 |
| immunogenicity, reactogenicity, and safety of human papillomavirus 16/18 as04-adjuvanted vaccine in japanese women: interim analysis of a phase ii, double-blind, randomized controlled trial at month 7. | a phase ii, double-blind, controlled randomized multicenter study with human papillomavirus (hpv) 16/18 as04 (3-o-desacyl-4'-monophosphoryl lipid a and aluminum hydroxide)-adjuvanted vaccine is ongoing in japanese women aged 20 to 25 years. an interim analysis was performed at month 7 (1 month after the third dose of vaccine) to determine reactogenicity, safety, and immunogenicity of the vaccine and to evaluate the baseline hpv-16/18 seropositivity and dna status of women. in the hpv-16/18 group ... | 2009 | 19574783 |
| distribution of human papillomavirus genotypes in archival cervical lesions in eastern inner mongolian autonomous region, china. | human papillomavirus (hpv) is the main etiologic factor for cervical cancer (cc). to investigate the prevalence of hpv types in archival cc and its precursors collected form tongliao area, which is located in the east of inner mongolian autonomous region, china, and compare the genotype distribution of hpv in cervical lesions between han chinese and mongolian. | 2009 | 19574785 |
| comparison of the hybrid capture ii assay with the human papillomavirus dna chip test for the detection of high-grade cervical lesions. | cervical intraepithelial neoplasia (cin) 2 is used as the threshold for treatment decisions. this study was conducted to evaluate the clinical efficacy of the hybrid capture ii assay (hc2) and the human papillomavirus (hpv) dna chip test (hdc) for detecting hpv in high-grade cervical lesions cin2 or greater, including adenocarcinoma (cin2+). seven hundred forty-one women with abnormal cervical cytology were evaluated with the hc2, the hdc, and histological assessment of the cervix. the overall a ... | 2009 | 19574786 |
| persistent high-risk human papillomavirus infections and other end-point markers of progressive cervical disease among women prospectively followed up in the new independent states of the former soviet union and the latin american screening study cohorts. | new end points are needed in future human papillomavirus (hpv) vaccine efficacy studies that accurately predict disease progression. | 2009 | 19574788 |
| human papillomavirus type 16 oncoprotein e7 suppresses cadherin-mediated cell adhesion via erk and ap-1 signaling. | human papillomaviruses (hpv) are the main etiological factor for cervical carcinoma. hpv-16 is the most prevalent high-risk hpv-genotype found in hpv-associated cancers. we studied the effect of hpv-16 e7 oncoprotein on cadherin-mediated cell adhesion. the expression of e7 strongly suppressed the cadherin-mediated cell adhesion in the rat fibroblast cell line 3y1. this suppression was associated with the decreased expression of n-cadherin at the transcriptional level. the treatment of 3y1 cells ... | 2009 | 19578744 |
| human papillomavirus e7 oncoprotein overrides the tumor suppressor activity of p21cip1 in cervical carcinogenesis. | the e7 oncoprotein of the high-risk human papillomaviruses (hpv) is thought to contribute to cervical carcinogenesis at least in part by abrogating cell cycle regulation. e7 can dysregulate the cell cycle through its interaction with several cellular proteins including the retinoblastoma suppressor protein prb, as well as the cyclin-dependent kinase inhibitor p21(cip1). inactivation of prb in cervical epithelia is not sufficient to explain the ability of e7 to cause cervical cancers in transgeni ... | 2009 | 19584294 |
| the potential impact of human papillomavirus vaccination in contemporary cytologically screened populations may be underestimated: an observational retrospective analysis of invasive cervical cancers. | the aim of this study was to determine the proportion of invasive cervical cancers attributable to human papillomavirus (hpv) types 16 and 18 in a contemporary, cytologically well-screened uk population. this was achieved in a retrospective observational analysis by hpv typing 453 archival invasive cervical cancers diagnosed between january 1, 2000 and september 1, 2006. pathological material was collected from 9 hospitals across wales (uk), and hpv typing and pathology review was conducted at a ... | 2009 | 19585507 |
| efficacy of human papillomavirus (hpv)-16/18 as04-adjuvanted vaccine against cervical infection and precancer caused by oncogenic hpv types (patricia): final analysis of a double-blind, randomised study in young women. | the human papillomavirus (hpv)-16/18 as04-adjuvanted vaccine was immunogenic, generally well tolerated, and effective against hpv-16 or hpv-18 infections, and associated precancerous lesions in an event-triggered interim analysis of the phase iii randomised, double-blind, controlled papilloma trial against cancer in young adults (patricia). we now assess the vaccine efficacy in the final event-driven analysis. | 2009 | 19586656 |
| anal cancer prevention in hiv-positive men and women. | the incidence of human papillomavirus-associated anal cancer is unacceptably high among hiv-positive men who have sex with men, and possibly in hiv-positive women. unlike most other malignancies occurring in the hiv-positive population, anal cancer is potentially preventable, using methods similar to those used to prevent cervical cancer in women. this review discusses the issues around screening to prevent anal cancer. | 2009 | 19587592 |
| age distribution of human papillomavirus infection and cervical neoplasia reflects caveats of cervical screening policies. | although a second age-related peak of human papillomavirus (hpv) infection is observed in many populations, it does not seem to have any impact on cervical screening policies. we examined the age-specific prevalence of hpv infection among 2,604 women enrolled for cervical screening and correlated the age at diagnosis of 2,491 cervical intraepithelial neoplasia grade 2/3 (cin2/3) lesions and 801 invasive cervical cancers (icc). two peaks of hpv infection were detected at 26-30 and 46-50 years, re ... | 2010 | 19588497 |
| dermatologic manifestations of hpv in hiv-infected individuals. | dermatologic human papillomavirus (hpv) infection in hiv patients manifests as both anogenital and nongenital skin disease. anogenital hpv-related disease includes benign condyloma acuminata, the most common cutaneous manifestation of genital hpv infection; intermediate malignancy or premalignant conditions including giant condyloma acuminata (also called buschke-loewenstein tumor), anal intraepithelial neoplasia, penile intraepithelial neoplasia, and vaginal or vulvar intraepithelial neoplasia; ... | 2009 | 19589298 |
| [treatment of respiratory papillomatosis--a case report on systemic treatment with bevacizumab]. | recurrent respiratory papillomatosis (rrp) is a known but rare disease, caused by human papilloma virus and characterised by multiple exophytic lesions and uncontrolled growth of papilloma in the respiratory tract. the most common complication of rrp is stenosis of the trachea. medical therapeutic options have so far been less effective. however, inhibition of vascular endothelial growth factor (vegf) by bevacizumab does appear to be an effective treatment option for rrp. | 2009 | 19591084 |
| cervical dysplasia and associated risk factors in a juvenile detainee population. | canada has licensed a human papilloma virus (hpv) vaccine for adolescent females, with the goal of decreasing the incidence of hpv infection and associated cervical cancer. this study identifies the juvenile detainee population as a high-risk group for hpv infection and therefore an important target for primary prevention. | 2009 | 19592281 |
| giant condyloma with demise secondary to meningococcemia in an infant boy. | human papilloma virus (hpv) is the most common sexually transmitted disease among adults in the usa; however, the presence of hpv in infants is rare. condyloma acuminata, a cutaneous, fungating lesion caused by hpv, has a generally mild course that often resolves spontaneously or can be managed both medically and surgically. typical treatments for condyloma include imiquimoid cream, podofilox gel, podophyllin resin, cryotherapy, laser surgery, tangential shave excision, and electrocautery. rapid ... | 2009 | 19596116 |
| predictors of human papillomavirus persistence among women with equivocal or mildly abnormal cytology. | we investigated short-term persistence of human papillomavirus (hpv) infection among 2,408 women with low-grade or equivocal cytological abnormalities followed for 24 months. odds ratios (ors) for persistence to the next 6-month visit were estimated by a discrete time survival model. prevalent hpv infections persisted longer in older women, but no association with age was found for incident hpv infections. increased likelihood of persistence was found among current smokers of >20 cigarettes per ... | 2010 | 19609952 |
| oral manifestations in human immunodeficiency virus infected children in highly active antiretroviral therapy era. | conducted a literature review to identify studies that reported on the oral manifestations in human immunodeficiency virus (hiv) infected children in highly active antiretrovial therapy (haart) era. | 2009 | 19614862 |
| transitional cell neoplasm of the nasolacrimal duct associated with human papillomavirus type 11. | tumors of the lacrimal sac are rare but noteworthy because of their significant potential to become malignant or life-threatening if treatment is delayed. dermatologists may be the first to encounter such neoplasms. | 2010 | 19615034 |
| identification of nucleolin as a protein that binds to human papillomavirus type 16 dna. | transcription, replication, and segregation of human papillomaviruses (hpvs) are regulated by various host factors, but our understanding of host proteins that bind to the hpv genome is limited. here we report the results of a search of cellular proteins that can associate with specific genomic regions of hpv type 16 (hpv16). we found that human nucleolin, an abundant nucleolar protein, was preferentially captured in vitro by an hpv16 genomic fragment from nucleotide positions (nt) 531-780. elec ... | 2009 | 19615975 |
| administration of hpv dna vaccine via electroporation elicits the strongest cd8+ t cell immune responses compared to intramuscular injection and intradermal gene gun delivery. | dna vaccines are an attractive approach to eliciting antigen-specific immunity. intracellular targeting of tumor antigens through its linkage to immunostimulatory molecules such as calreticulin (crt) can improve antigen processing and presentation through the mhc class i pathway and increase cytotoxic cd8+ t cell production. however, even with these enhancements, the efficacy of such immunotherapeutic strategies is dependent on the identification of an effective route and method of dna administr ... | 2009 | 19622402 |
| age-specific prevalence of hpv genotypes in cervical cytology samples with equivocal or low-grade lesions. | to define the spectrum of human papillomavirus (hpv) types and establish an age limit for triage hpv testing in atypical squamous cells of undetermined significance (ascus) and low-grade squamous intraepithelial lesion (lsil). | 2009 | 19623178 |
| importance of specimen type in detecting human papillomavirus dna from the female genital tract. | hpv testing is a valuable tool in cervical cancer screening and efficacy assessment of hpv vaccines. concordance of specimens from three sites for detection of hpv dna in the female genital tract was evaluated. at a single visit, the following specimens were collected: an endo-ecto-cervical swab (eec), labial/vulvar/perineal/perianal swab (lvpp) and cervicovaginal lavage (cvl). specimens were evaluated with hpv6, hpv11, hpv16, and hpv18 type- and gene-specific pcr assays. of the 898 women evalua ... | 2009 | 19626611 |
| genetic diversity of human papillomavirus type 16 e6, e7, and l1 genes in italian women with different grades of cervical lesions. | high-risk human papillomaviruses (hpvs) are risk factors for the development of cervical cancer. hpv 16 is the most common type, being present in about 60% of cervical cancers worldwide. previous studies have reported upon the association between hpv 16 e6 variants and increased risk of cervical intraepithelial neoplasia and invasive cervical cancer. in this study, the presence of hpv 16 polymorphisms in the e6, e7, and l1 genes was investigated in relation to the presence of high-grade lesions. ... | 2009 | 19626616 |
| [the expressions of ppar-gamma, cox-2 in the lesions of patients with condyloma acuminatum and bowenoid papulosis]. | to investigate the expression of ppar-gamma, cox-2 in the skin lesion of condyloma acuminatum and bowenoid papulosis. | 2009 | 19627000 |
| molecular epidemiology of sexually transmitted human papillomavirus in a self referred group of women in ireland. | human papillomavirus (hpv) causes cervical cancer and external genital warts. the purpose of this study is to document the genotype distribution of hpv in females aged between 18 and 34 who self-referred to an sti clinic with visible external genital warts (egw). scrapings were taken from visible external genital warts (egw). these scrapings were analysed by pcr for the presence of hpv dna. positive samples were then genotyped by means of a commercially available assay (lipa). a comparison of ge ... | 2009 | 19627586 |
| hpv 18 antibody levels, clinical efficacy and induced immune memory: a trio? | 2009 | 19628059 | |
| use of fta card for dry collection, transportation and storage of cervical cell specimen to detect high-risk hpv. | the fta elute micro card, which enable the collection, transport, and archiving of dna could be an attractive alternative to a liquid based collection system for detection of human papillomavirus (hpv). | 2009 | 19628427 |
| [human papillomavirus genotype profile in kinshasa, democratic republic of the congo: implications for vaccination]. | proposed anti-human papillomavirus (hpv) vaccines, i.e., cervarix (glaxomith-kline) and gardasil (merck), are designed to prevent infection by two high-risk hpv types, i.e., 16 and 18, for which estimation mainly in western europe and north america have demonstrated a prevalence 60 to 70%. | 2008 | 19639831 |
| prognostic significance of hpv physical status and integration sites in cervical cancer. | human papilloma virus (hpv) infection is the major cause of cervical cancer and integration of hpv dna into the host cell genome is believed to be essential for malignant transformation. mirnas are a class of 19-24 nt non-coding rnas that regulate gene expression primarily through post transcriptional repression or m-rna degradation in a sequence specific manner. the aim of this study was to determine the frequency of hpv16 and 18 integrated and episomal forms and to evaluate its prognostic sign ... | 2009 | 19640172 |
| epidemiologic natural history and clinical management of human papillomavirus (hpv) disease: a critical and systematic review of the literature in the development of an hpv dynamic transmission model. | natural history models of human papillomavirus (hpv) infection and disease have been used in a number of policy evaluations of technologies to prevent and screen for hpv disease (e.g., cervical cancer, anogenital warts), sometimes with wide variation in values for epidemiologic and clinical inputs. the objectives of this study are to: (1) provide an updated critical and systematic review of the evidence base to support epidemiologic and clinical modeling of key hpv disease-related parameters in ... | 2009 | 19640281 |
| chimeric l1-l2 virus-like particles as potential broad-spectrum human papillomavirus vaccines. | the amino (n) terminus of the human papillomavirus (hpv) minor capsid protein l2 can induce low-titer, cross-neutralizing antibodies. the aim of this study was to improve immunogenicity of l2 peptides by surface display on highly ordered, self-assembled virus-like particles (vlp) of major capsid protein l1, and to more completely characterize neutralization epitopes of l2. overlapping peptides comprising amino acids (aa) 2 to 22 (hereafter, chimera or peptide 2-22), 13 to 107, 18 to 31, 17 to 36 ... | 2009 | 19640991 |
| racial survival disparity in head and neck cancer results from low prevalence of human papillomavirus infection in black oropharyngeal cancer patients. | the burden of squamous cell carcinoma of the head and neck (scchn) is greater for blacks than for whites, especially in oropharyngeal cases. we previously showed retrospectively that disease-free survival was significantly greater in white than in black scchn patients treated with chemoradiation, the greatest difference occurring in the oropharyngeal subgroup. oropharyngeal cancer is increasing in incidence and in its association with human papillomavirus (hpv) infection; hpv-positive oropharyng ... | 2009 | 19641042 |
| down-regulation of grim-19 expression is associated with hyperactivation of stat3-induced gene expression and tumor growth in human cervical cancers. | cervical cancer is the most common malignant disease responsible for the deaths of a large number of women in the developing world. although certain strains of human papillomavirus (hpv) have been identified as the cause of this disease, events that lead to formation of malignant tumors are not fully clear. stat3 is a major oncogenic transcription factor involved in the development and progression of a number of human tumors. however, the mechanisms that result in loss of control over stat3 acti ... | 2009 | 19642906 |
| human papillomavirus genotyping using an automated film-based chip array. | the infiniti hpv-quad assay is a commercially available genotyping platform for human papillomavirus (hpv) that uses multiplex pcr, followed by automated processing for primer extension, hybridization, and detection. the analytical performance of the hpv-quad assay was evaluated using liquid cervical cytology specimens, and the results were compared with those results obtained using the digene high-risk hpv hc2 test (hc2). the specimen types included surepath and preservcyt transport media, as w ... | 2009 | 19644025 |
| obstetrician-gynecologists and the hpv vaccine: practice patterns, beliefs, and knowledge. | human papillomavirus (hpv), the most common sexually transmitted infection in the united states, can be contracted by young girls shortly after sexual debut. human papillomavirus can lead to cervical and anogenital cancers and genital warts. a vaccine has been developed to protect against precancerous lesions. we examined obstetrician-gynecologists' practices, opinions, and knowledge regarding this vaccine. | 2009 | 19646670 |
| principles and analytical performance of abbott realtime high risk hpv test. | abbott realtime high risk (hr) hpv is a new automated, qualitative real-time pcr test for detection of dna from 14 high-risk human papillomavirus (hpv) types (16, 18, 31, 33, 35, 39, 45, 51, 52, 56, 58, 59, 66, and 68) in cervical specimens. the test can also differentiate between hpv 16, hpv 18 and non-hpv 16/18 types in a single reaction. objectives: this article describes the principles of assay design and the analytical performance of abbott realtime hr hpv. | 2009 | 19651363 |
| clinical performance of the aptima hpv assay for the detection of high-risk hpv and high-grade cervical lesions. | human papillomavirus (hpv) dna testing is widely used in conjunction with papanicolaou (pap) testing in cervical cancer screening programs to improve the detection of high-grade lesions. while hpv dna test sensitivity is good, an improvement in specificity is desired. detection of hpv mrna may improve specificity. the aptima hpv assay detects the mrna of 14 high-risk hpv types in liquid-based cytology specimens. | 2009 | 19651370 |
| a comparative review of laboratory-developed tests utilizing invader hpv analyte-specific reagents for the detection of high-risk human papillomavirus. | background: testing for human papillomavirus (hpv) has emerged as an important component of cervical cancer screening and disease management. analytic performance (sensitivity, specificity, positive predictive value, negative predictive value, accuracy) and clinical relevance are important criteria by which any new test must be reviewed. objective: this paper compares laboratory-developed tests, utilizing invader analyte-specific reagents (asrs) for the detection of oncogenic hpv dna, to the dig ... | 2009 | 19651372 |
| the clinical performance of invader technology and surepath when detecting the presence of high-risk hpv cervical infection. | testing for high-risk genotypes of the human papillomavirus (hr hpv) has been fully integrated into the management algorithms for the prevention of cervical cancer. the literature is limited with regard to the evaluation of the clinical performance of laboratory-developed tests (ldt) utilizing invader v2.0 assay (thirdwave/hologic, madison, wi, usa) for the detection of hr hpv. | 2009 | 19651373 |
| commentary on statement on human papillomavirus test utilization. | 2009 | 19653706 | |
| people seeking health information about human papillomavirus via the internet have a very high level of anxiety. | a website with evidence-based information on human papillomavirus (hpv) has been developed at the university of antwerp, belgium. visitors were asked to fill in a web-based form, including the state-trait anxiety inventory (stai), to obtain information on their profile. during the study period, 232 of 3638 (6.4%) visitors filled in the form. in our study, people looking for hpv information on the internet showed high anxiety levels. three determinants contributed to the stai score: a previous hp ... | 2009 | 19653966 |
| ulbp6/raet1l is an additional human nkg2d ligand. | to date five ulbp/raet (ul16-binding protein, also known as retinoic acid early transcript) genes, encoded on human chromosome 6q24.2-q25.3, have been shown to encode ligands of the activating immunoreceptor nkg2d. here, we show that a sixth gene, ulbp6/raet1l, is a polymorphic locus that expresses a functional transcript. ulbp6 had a more restricted expression profile in cell lines and primary human tissues than other nkg2d ligands, but expression was detected in several human papillomavirus-po ... | 2009 | 19658097 |
| epidemiology and risk factors for human papillomavirus infection in a diverse sample of low-income young women. | two hpv vaccines prevent infection with hpv-16 and hpv-18, high-risk (cancer-associated) hpv types which together cause approximately 70% of cervical cancers; one vaccine also prevents hpv-6 and hpv-11, which together cause approximately 90% of anogenital warts. defining type-specific hpv epidemiology in sexually experienced women will help estimate the potential clinical benefits of vaccinating this population. | 2009 | 19665924 |
| carbonic anhydrase ix and human papillomavirus as diagnostic biomarkers of cervical dysplasia/neoplasia in women with a cytologic diagnosis of atypical glandular cells: a gynecologic oncology group study in united states. | high-risk human papillomavirus (h-hpv) infection is strongly linked to cervical neoplasia, but its role in detecting glandular lesions (gls) is unclear. in the cervix, carbonic anhydrase ix (ca-ix) is expressed in cervical neoplasia, but rarely in the benign cervix. the diagnostic utility of these biomarkers was evaluated in women with a cytologic diagnosis of atypical glandular cells (agc). h-hpv was detected using hybrid capture 2 (hc2) in liquid-based cytology, and ca-ix immunoreactivity was ... | 2009 | 19670419 |
| no indications for hpv involvement in the hypertrophic skin lesions of a darier disease case without atp2a2 gene mutations. | darier disease (dd) is a relatively common genodermatosis characterized by impaired differentiation and abnormal cell-to-cell adhesion. haploinsufficiency of the atp2a2 gene product, sarco/endoplasmic reticulum ca(2+) atpase isoform 2 (serca2), is the underlying cause of most cases. although dd may have a papillomatous appearance, few and controversial results have been reported about the role of human papillomavirus (hpv) in this disease. the aim of this study was to determine a possible correl ... | 2009 | 19674205 |
| evaluation of a prototype real-time pcr assay for carcinogenic human papillomavirus (hpv) detection and simultaneous hpv genotype 16 (hpv16) and hpv18 genotyping. | results from a prototype real-time pcr assay that separately detected human papillomavirus genotype 16 (hpv16), hpv18, and 12 other carcinogenic hpv genotypes in aggregate (cobas 4800 hpv test) and results from a pcr assay that detects 37 hpv genotypes individually (linear array) were compared using a convenience sample of cervical specimens (n = 531). the percentage of total agreement between the two assays was 94.7% (95% confidence interval, 92.5 to 96.5%). the linear array test was more likel ... | 2009 | 19675214 |
| concurrent human papillomavirus-associated tonsillar carcinoma in 2 couples. | we describe 2 nonsmoking, nondrinking couples who developed human papillomavirus (hpv)-associated tonsillar cancer within 12 months of each other. after histopathologic evaluation, hpv l1, e2, e6, and lcr regions were amplified, and phylogenetic analysis of amplimers was determined. quantitative polymerase chain reaction targeting hpv-16/18 l1 and e7 regions and p16 immunohistochemistry were performed. tissues were hpv-16 positive, with distinct intercouple nucleotide differences and multiple un ... | 2009 | 19678755 |
| value of p16(ink4a) as a marker of progression/regression in cervical intraepithelial neoplasia grade 1. | the objective of this study was to evaluate the usefulness of p16(ink4a) staining to classify cervical intraepithelial neoplasia grade 1 according to its progression/regression risk. | 2009 | 19683687 |
| digene hpv genotyping rh test ruo: comparative evaluation with inno-lipa hpv genotyping extra test for detection of 18 high-risk and probable high-risk human papillomavirus genotypes. | standardized and validated methods for the specific detection and identification of a spectrum of high-risk (hr) hpv genotypes will be necessary if hpv genotyping gains an important role in the clinical management of hpv-related precancerous lesions and cancers. | 2009 | 19683958 |
| human papillomavirus genotype distributions inform screening and vaccination policy. | 2009 | 19684300 | |
| molecular mechanisms of human papillomavirus-induced carcinogenesis. | approximately 20% of all cancers are associated with infectious agents. among them, human papillomaviruses (hpvs) are very common and are now recognized as the etiological agent of cervical cancer, the second most common cancer in women worldwide, and they are increasingly linked with other forms of dysplasia. carcinogenesis is a complex and multistep process requiring the acquisition of several genetic and/or epigenetic alterations. hpv-induced neoplasia, however, is in part mediated by the int ... | 2009 | 19684440 |
| detection and typing of human papillomavirus nucleic acids in biological fluids. | human papillomaviruses (hpv) are the etiologic agents of cancer of the uterine cervix and several other neoplasias. detection of hpv infection will improve the sensitivity of primary and secondary screening of cervical cancer. the clinical indications for the use of hpv tests will have to consider the natural history of hpv infection and diseases, and the multiplicity of types involved. signal amplification hpv dna tests detect several high-risk hpv types, are standardized, commercially availabl ... | 2009 | 19684443 |
| from causality to prevention - the example of cervical cancer: my personal contribution to this fascinating history. | the history of the generation of an hypothesis linking human papillomavirus to cervical cancer, as well as a summary of the various molecular epidemiological studies undertaken to confirm such hypothesis are described. | 2009 | 19684449 |
| verrucous oral lesions: possibly not so innocuous after all. squamous papilloma. | 2009 | 19685649 | |
| effect of human papillomavirus on cell cycle-related proteins p16, ki-67, cyclin d1, p53, and proex c in precursor lesions of cervical carcinoma: a tissue microarray study. | in-depth study of cell cycle proteins and human papillomavirus (hpv) genotyping can provide useful information about the malignant potential of precursor lesions of cervical carcinoma (cc). immunostaining of cell cycle-related proteins (p16, cyclin d1, ki-67, p53, and proex c) was evaluated using tissue microarrays, and hpv genotypes were identified in 144 cervical tissue specimens encompassing normal or benign epithelial lesions, low- and high-grade squamous intraepithelial lesions (lsil and hs ... | 2009 | 19687314 |
| anal pap smears: should we be doing them? | to identify the need to perform anal papanicolau (pap) smears for diagnosing histologic changes associated with human papilloma virus (hpv) infection in order to provide early intervention for the prevention of anal cancer. to offer the primary care provider information, based on evidence-based research, about identifying the high-risk patient using risk factors, instructions on performing the anal pap smear, interpreting the results, and initiating treatment interventions and/or referrals for c ... | 2009 | 19689440 |