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single low-dose red light is as efficacious as methyl-aminolevulinate--photodynamic therapy for treatment of acne: clinical assessment and fluorescence monitoring.this controlled study investigated single low-dose red light photodynamic therapy and methyl-aminolevulinate (mal) for treatment of moderate to severe facial acne in 19 patients. the right cheek was treated with mal (160 mg/g) for 3 h prior to illumination. the left cheek received red light only. both cheeks were illuminated with narrow-band red light (635 nm) at a light dose of 15 j/cm2. the global severity of acne was assessed at baseline and at follow-up, 10 and 20 weeks after treatment. fluo ...200919688149
5-ala derivative-mediated photoinactivation of propionibacterium acnes. 200919709860
microbiological examination of donated human cardiac tissue in heart valve banking.microbiological examination of donated human cardiac tissue is a necessary procedure for heart valve banks to determine the biological safety of preserved allografts. test protocols must be validated to prevent false-negative outcomes that pose a risk of infection to recipients of the tissue. the heart valve bank in rotterdam evaluated a validated, alternative entry test for donated tissues to compare the performance of its standard microbiological examinations.201019709896
non-purulent low-grade infection as cause of pain following shoulder surgery: preliminary results.low-grade infection was systematically searched for in all revision shoulder surgeries by harvesting tissue samples. ten consecutive patients were identified with a non-purulent low-grade infection of the shoulder. all of these patients suffered from pain and eight were stiff. preoperative aspiration in eight patients yielded bacterial growth in only one case. serum c-reactive protein levels were normal in seven out of 10 cases. propionibacterium acnes was identified in seven, coagulase-negative ...200919711173
detection of bacterial contamination of apheresis platelets in a chinese blood center.bacterial contamination of platelets is considered as the most frequent infectious risk of transfusion. the prevalence of bacterial contamination has been reported and varied considerably in different countries, but the data for bacterial contamination of platelets in china are rarely reported. eight thousand apheresis platelet concentrates (pcs) were analysed by aerobic and anaerobic cultures. ten millilitres of pcs were inoculated into aerobic and anaerobic bottles (5 ml each), followed by the ...200919719475
squalene as a target molecule in skin hyperpigmentation caused by singlet oxygen.based on our previous finding (biochem. biophys. res. commun., 223, 578-582, 1996) of singlet oxygen generation from coproporphyrin excreted on the skin surface from propionibacterium acnes, we hypothesized that singlet oxygen formed in this way under uv exposure would promote peroxidation of skin surface lipids. we found that squalene was oxidized efficiently by singlet oxygen derived from coproporphyrin under uv exposure, and that the rate constant of squalene peroxidation by singlet oxygen wa ...200919721223
comparisons of subgingival microbial profiles of refractory periodontitis, severe periodontitis, and periodontal health using the human oral microbe identification microarray.this study compared the subgingival microbiota of subjects with refractory periodontitis (rp) to those in subjects with treatable periodontitis (grs = good responders) or periodontal health (ph) using the human oral microbe identification microarray (homim).200919722792
postoperative joint infections due to propionibacterium species: a case-control study.we compared 40 patients with propionibacterium acnes postoperative joint infection to a cohort of uninfected patients. infection manifested a median of 210 days after surgery. most patients with joint prostheses underwent hardware removal. prior joint surgery (odds ratio [or], 28.2) and male sex (or, 7.2) were independent risk factors for infection.200919725786
nicotinamide inhibits propionibacterium acnes-induced il-8 production in keratinocytes through the nf-kappab and mapk pathways.propionibacterium acnes (p. acnes) has been implicated in the inflammatory phase of acne vulgaris. it has been shown to activate interleukin-8 (il-8) secretion by interacting with toll-like receptor 2 (tlr-2) on the surface of keratinocytes. nicotinamide has been shown to be an effective treatment for skin inflammation in various conditions, including acne vulgaris.200919726162
in vitro activity of chlorhexidine and pentane-1,5-diol and their combination on candida albicans, staphylococcus aureus and propionibacterium acnes. 200919734980
adjuvant effect of lps and killed propionibacterium acnes on the development of experimental gastrointestinal nematode infestation in sheep.gastrointestinal helminthic infection is an important worldwide sheep disease. the emergence of anthelminthic resistance has led to drives to seek new means of therapeutic control of helminthiasis in sheep. several data demonstrated the adjuvant effect of propionibacterium acnes on resistance to infection. herein, we evaluate the adjuvant effect of the commercial suspension containing lps and p. acnes on experimental helminthiasis. sheep received three doses of lps and p. acnes commercial suspen ...200919751472
antigen-dependent rescue of nose-associated lymphoid tissue (nalt) development independent of ltbetar and cxcr5 signaling.nose-associated lymphoid tissue (nalt) in the rodent upper respiratory tract develops postnatally and is considered to be independent of several factors known to be involved in the organogenesis of ln and peyer's patches (pp). in this study we demonstrate that at least two different pathways result in nalt development. following nalt anlage formation the intrinsic pathway relies on a signaling cascade including those mediated through the chemokine receptor cxcr5 and the lymphotoxin beta receptor ...200919757439
benzoyl peroxide: a review of its current use in the treatment of acne vulgaris.owing to the use of topical and systemic antibiotics for acne vulgaris, the incidence of antibiotic-resistant propionibacterium acnes is increasing worldwide. topical benzoyl peroxide (bpo) is an alternative to antibiotics in the treatment of acne vulgaris.200919761357
lactobacilli and dairy propionibacterium with potential as biopreservatives against food fungi and yeast contamination.naturally fermented and raw foods contain a range of organisms that may have benefit as additives in some foods and food processing. in particular, potential anti-fungal properties of these organisms may be potentially utilised as natural alternatives to chemical additives used to delay and prevent spoilage by fungi and yeast. this study examined 12 novel bacteria previously isolated from food as possible biopreservatives. the bacteria from the lactobacilli and dairy propionibacterium groups wer ...200919764616
emerging drugs for acne.acne vulgaris is a common skin disorder that affects most individuals at some point in their lives. it may result in significant morbidity, including cutaneous scarring and psychological impairment. current treatments include topical retinoids, benzoyl peroxide, topical and systemic antibiotics, and systemic isotretinoin. there are growing concerns of rising antibiotic resistance, significant side effects of isotretinoin therapy, and lack of safe and effective treatment for pregnant females. rec ...200919772370
efficacy of antibiotic therapy for sapho syndrome is lost after its discontinuation: an interventional study.the acronym sapho was introduced in 1987 to unify the various descriptions of a seronegative arthritis associated with skin manifestations and to show synovitis, acne, pustulosis, hyperostosis, and osteitis with and without sterile multifocal osteomyelitis. the etiology of sapho syndrome is unknown, but an association with infection by semipathogenic bacteria like propionibacterium acnes has been suggested. we conducted an interventional study of sapho patients receiving antibiotics.200919772564
new insights into synovitis, acne, pustulosis, hyperostosis, and osteitis (sapho) syndrome.in 1987, synovitis, acne, pustulosis, hyperostosis and osteitis (sapho) syndrome was proposed as an umbrella term for a group of diseases with similar musculoskeletal manifestations, in particular hyperostosis of anterior chest wall, synovitis, and multifocal aseptic osteomyelitis, observed in association with dermatologic conditions such as palmoplantar pustulosis, severe acne, and hidradenitis suppurativa. despite recent advances in our understanding of the epidemiologic, pathophysiologic, and ...200919772827
incidence, clinical features, causative organisms, and visual outcomes of delayed-onset pseudophakic endophthalmitis.to report the incidence, clinical features, causative organisms, and visual outcomes associated with delayed-onset pseudophakic endophthalmitis.200919787601
correlation of nosocomial bloodstream infection incidences: an ecological study.this study aimed to correlate nosocomial bloodstream infections (nbis) across time against the ecological effect of infection control activities. all patients hospitalised >or=48h in the haematology and intensive care departments of a university hospital and discharged between 1 january 2004 and 30 june 2006 were prospectively included. the case definition of nbi infection was: (1) at least one positive blood culture justified by clinical signs, or (2) at least two positive blood cultures when t ...200919788948
photodynamic therapy of acne vulgaris using 5-aminolevulinic acid 0.5% liposomal spray and intense pulsed light in combination with topical keratolytic agents.increasing antibiotic resistance of propionibacterium acnes and growing awareness on the side effects of topical and systemic drugs in the treatment of acne vulgaris by physicians and patients have paved the way for a search into new efficacious and safe treatment modalities such as photodynamic therapy (pdt). although the efficacy of pdt using 20% 5-aminolevulinic acid (ala) cream has been established, phototoxic side effects limit its use. the 5-ala concentration can be lowered by a factor of ...201019796088
interleukin-10 secretion from cd14+ peripheral blood mononuclear cells is downregulated in patients with acne vulgaris.acne is a common chronic inflammatory dermatosis of the pilosebaceous unit. it is characterized by seborrhoea, comedone formation and an inflammatory response consistent with defective cellular immunity to propionibacterium acnes.201019796181
comparative in-vitro activity of ceftazidime (gr-20263) and other beta-lactamase stable cephalosporins against anaerobic bacteria.the in-vitro activity of ceftazidime was determined against 586 clinical isolates of anaerobic bacteria by an agar-dilution technique and compared with that of cefuroxime, moxalactam and cefoxitin. at 16 mg/l, only 60% of all isolates were inhibited by ceftazidime, compared to 79% by cefuroxime, 81% by moxalactam and 80% by cefoxitin. ceftazidime was relatively inactive against bacteroides fragilis group, lactobacillus and clostridium species other than cl. perfringens. peptococcus, peptostrepto ...198119802974
propionibacterium acnes and sebaceous lipogenesis: a love-hate relationship?in this issue, iinuma et al. show that propionibacterium acnes (p. acnes)-conditioned medium and formalin-killed p. acnes augment intracellular lipid formation in hamster sebocytes by increasing the de novo synthesis of triacylglycerols. this commentary summarizes the current knowledge of the association of p. acnes with sebaceous lipogenesis, inflammation, and innate immunity, and points out the concurrent evidence that p. acnes-induced lipids may represent a recruitment of allies and/or enemie ...200919809423
suppressive effects of 1,4-dihydroxy-2-naphthoic acid administration on bone resorption.the main component of the metabolic by-products of fermentation by propionibacterium freudenreichii et-3 is 1,4-dihydroxy-2-naphthoic acid (dhna), which has a naphthoquinone skeleton, as in vitamin k2. this study showed that dhna improved bone mass reduction with osteoporosis model mice caused by fk506.201019813044
rapid identification of propionibacterium acnes from blood cultures by fluorescence in situ hybridization.a newly designed probe for rapid identification of propionibacterium acnes by fluorescence in situ hybridization was evaluated using 111 isolates from subculture and showed 100% sensitivity and specificity. a sensitivity of 95% and a specificity of 100% were achieved with direct application on 55 blood cultures containing gram-positive rods.201019815363
effect of konjac glucomannan hydrolysates and probiotics on the growth of the skin bacterium propionibacterium acnes in vitro.the synbiotic ability of probiotic bacteria and konjac glucomannan hydrolysates (gmh) to inhibit acne-inducing bacterium, propionibacterium acnes growth was studied in vitro. all probiotic bacteria strains tested were able to inhibit the growth of this species of skin bacterium where the inhibition was significantly (p < 0.01) enhanced by the presence of the gmh prebiotic. as the current treatment of acne is based on topical or systemic drugs, it is worth examining further the biotherapeutic act ...201019818083
detection and hazard assessment of pathogenic microorganisms in medical wastes.this study was undertaken to investigate the types and concentrations of microbial agents in various medical wastes as well as to characterize their survivals in these wastes at different temperatures for microbial risk assessment. medical wastes collected from 5 major hospitals in south korea were classified and stored at three different temperatures (-20, 6, and 30 degrees c). presence of various microorganisms such as pathogenic viruses and bacteria were investigated by both cultivation and b ...200919827491
characterization of bacterial flora in persistent apical periodontitis lesions.microorganisms are able to survive and induce persistent infection in periapical tissues. the aim of this study was to investigate the composition of the microflora of persistent apical periodontitis lesions.200919832803
treatment of active acne with an er:glass (1.54 microm) laser: a 2-year follow-up study.to investigate the effects of the 1.54 microm wavelength on active lesions of the face and of the back at the 2-year follow-up.200619839169
taurine bromamine: a new therapeutic option in inflammatory skin diseases.acne vulgaris is a multifactorial inflammatory skin disease. one of the pathogenic factors in acne is propionibacterium acnes (p. acnes). traditional treatment of acne lesions involves topical application of antibiotics with anti-bacterial and anti-inflammatory properties. however, a failure of this therapy is widely associated with emergence of resistant bacteria. therefore, a search for alternative topical anti-acne drugs is necessary. taurine bromamine (taubr), the physiological product of hy ...200919847145
characteristic of milk whey culture with propionibacterium freudenreichii et-3 and its application to the inflammatory bowel disease therapy.after the screening of microorganism culture, the culture of propionibacterium freudenreichii et-3 in the milk whey (milk whey culture) was found to stimulate the growth of our own bifidobacteria in the colon but not the growth of other microorganisms. one of the active substances was identified as 1,4-dihydroxy-2-naphthoic acid (dhna).in healthy volunteers, the ingestion containing milk whey culture significantly increased the population of bifidobacteria to total fecal bacterium. in the tnbs-i ...200719847949
oropharyngeal flora changes after tonsillectomy.we aimed to investigate the effect of tonsillectomy on oropharyngeal flora in children who underwent tonsillectomy for chronic recurrent tonsillitis.200919861199
suture-related complications after cataract surgery: a patient safety issue. 200919878852
antimicrobial activity and stability of rhinacanthins-rich rhinacanthus nasutus extract.rhinacanthins-rich rhinacanthus nasutus (rrn) extract was prepared and standardized to contain total rhinacantins not less than 70% w/w. in this study, antimicrobial activities of the rrn extract as well as rhinacanthin-c against streptococcus mutans, propionibacterium acnes, helicobacter pylori, staphylococcus aureus, s. epidermidis and candida albicans were evaluated by microdilution assay. it was found that the rrn extract exhibited potent bactericidal activity against s. mutans with mic and ...201019879741
bacterial resistance to antibiotics in acne vulgaris: an in vitro study.acne vulgaris is one of the most common skin disorders in youth especially during the puberty.200819882009
propionibacterium acnes infection after shoulder arthroplasty: a diagnostic challenge.this study reviewed a series of patients diagnosed with propionibacterium acnes infection after shoulder arthroplasty in order to describe its clinical presentation, the means of diagnosis, and provide options for treatment.201019884021
sapho syndrome: is a range of pathogen-associated rheumatic diseases extended?sapho syndrome, representing a constellation of synovitis, acne, palmo-plantar pustulosis, hyperostosis, and osteitis, is now recognized as a distinct medical entity: a reactive infectious osteitis. genetic, immunological, and bacterial mechanisms are implicated in the development of the disease. diagnostic problems may arise due to non-complete manifestations of sapho: either acne and arthritis or acne and anterior wall osteitis with an unclear pustulosis history. the interventional study of as ...200919895718
propionibacterium acnes as an etiological agent of arthroplastic and osteosynthetic infections--two cases with specific clinical presentation including formation of draining fistulae.this report describes two patients with orthopaedic implant infections, with specific clinical presentations including formation of draining fistulae. propionibacterium acnes was isolated in multiple cultures in both cases. phenotypic and genetic characterisation of the isolates clearly emphasizes the significance of p. acnes as an etiological agent of implant infections. these infections are insidious with delayed presentation of symptoms and may have been overlooked because of the consideratio ...201019895893
18beta-glycyrrhetinic acid ameliorates acute propionibacterium acnes-induced liver injury through inhibition of macrophage inflammatory protein-1alpha.18beta-glycyrrhetinic acid (ga), the major bioactive component of licorice root extract, has a protective effect on hepatic injury and exhibits antiinflammatory activity. here, we investigate the effect of ga in propionibacterium acnes-induced acute inflammatory liver injury. c57bl/6 mice were primed with p. acnes followed by lipopolysaccharide challenge to induce fulminant hepatitis. ga (75 mg/kg) or vehicle control was administered intraperitoneally daily 1 day after p. acnes priming, and ga s ...201019897483
acne vaccines targeting propionibacterium acnes.acne vulgaris is one of the most common skin diseases and can affect a large number of individuals at some point in their lives. though the disease is multi-factorial, the gram-positive, anaerobic bacterium propionibacterium acnes (p. acnes), a member of resident skin microflora, is implicated in acne inflammation and associated with acne lesions. common treatments such as antibiotic or benzoyl peroxide nonspecifically reduce bacteria population on the skin, which may disrupt homeostasis and cau ...200919907403
tibial chronic osteomyelitis due to propionibacterium acnes in a patient with sickle cell anemia. 201019913448
metabolism of conjugated linoleic acids and 18 : 1 fatty acids by ruminal bacteria: products and mechanisms.cultures of ruminal bacteria known to metabolize unsaturated fatty acids were grown in medium containing 50 microg ml(-1) of geometric and positional isomers of conjugated linoleic acid (cla) or 18 : 1 fatty acids and 37.4 % deuterium oxide to investigate the mechanisms responsible for fatty acid metabolism. butyrivibrio fibrisolvens jw11 converted cis-9,trans-11-18 : 2 and trans-9,trans-11-18 : 2 to trans-11-18 : 1 as the main product, labelled at c-9, and metabolized trans-10,cis-12-18 : 2 to ...201019926650
primary canaliculitis.to review the clinical findings, treatment outcomes, and microbiology of primary canaliculitis.200919935254
in vitro antimicrobial activity of silver-processed catheters for neurosurgery.to investigate the in vitro antibacterial activity of silver-processed catheters for use in neurosurgery using clinically predictive tests.201019942617
an in vitro study on bacterial growth interactions and intestinal epithelial cell adhesion characteristics of probiotic combinations.the aims of this study were to examine long-term growth interactions of five probiotic strains (lactobacillus casei 01, lactobacillus plantarum ha8, lactobacillus rhamnosus gg, lactobacillus reuteri atcc 55730 and bifidobacterium lactis bb12) either alone or in combination with propionibacterium jensenii 702 in a co-culture system and to determine their adhesion ability to human colon adenocarcinoma cell line caco-2. growth patterns of probiotic lactobacillus strains were not considerably affect ...201019949794
suture-related corneal infections: should all sutures be routinely removed after phacoemulsification? 200919969244
suture-related corneal infections. 200919969245
identification of bacteria enduring endodontic treatment procedures by a combined reverse transcriptase-polymerase chain reaction and reverse-capture checkerboard approach.this study identified the bacterial taxa enduring endodontic treatment procedures by using a combined 16s ribosomal rna-based reverse-transcriptase polymerase chain reaction (rt-pcr) and reverse-capture checkerboard hybridization approach.201020003934
sebum free fatty acids enhance the innate immune defense of human sebocytes by upregulating beta-defensin-2 expression.various sebum free fatty acids (ffas) have shown antibacterial activity against a broad range of gram-positive bacteria, resulting in the suggestion that they are accountable, at least partially, for the direct antimicrobial activity of the skin surface. in this study, we examined the effects of sebum ffas on the antimicrobial peptide (amp)-mediated innate immune defense of human sebocytes. incubation of lauric acid, palmitic acid, or oleic acid (oa) with human sebocytes dramatically enhanced th ...201020032992
identification of a secreted lipolytic esterase in propionibacterium freudenreichii, a ripening process bacterium involved in emmental cheese lipolysis.lipolysis plays an important role in the formation of cheese flavor. in emmental cheese, the main part of lipolysis has been associated with the presence of propionibacterium freudenreichii, a species used as a ripening culture. our aim was to identify the most probable lipolytic esterase(s) involved in cheese lipolysis by p. freudenreichii. since cheese lipolysis mainly occurs during p. freudenreichii growth, we hypothesized that p. freudenreichii possesses secreted lipolytic esterase(s). for 1 ...201020038704
progressive macular hypomelanosis is associated with a putative propionibacterium species. 201020043017
in vitro activities of azole antifungal agents against propionibacterium acnes isolated from patients with acne vulgaris.the gram-positive bacterium propionibacterium acnes is the causative agent of acne vulgaris. antibiotics such as tetracycline and macrolide derivatives are used to treat this skin disease; however, the isolation frequency of antibiotic-resistant p. acnes has been increasing. the anti-p. acnes activity of imidazole antifungal agents was reported more than 20 years ago, and since then, new azole antifungal agents have been marketed. thus, this study determined the in vitro activities of azole anti ...201020045949
syntheses of carnosic acid and carnosol, anti-oxidants in rosemary, from pisiferic acid, the major constituent of sawara.carnosic acid (2), a major anti-oxidant in rosemary (rosmarinus officinalis), was synthesized from pisiferic acid (1), the major constituent of sawara (chamaecyparis pisifera), via ortho-oxidation of the phenol using meta-chlorobenzoyl peroxide (mcbpo), chloroacetyl meta-chlorobenzoyl peroxide (camcbpo) or 2-iodoxybenzoic acid (ibx). carnosol (3), another anti-oxidant in rosemary, was synthesized from carnosic acid by oxidation with silver oxide. potent antibacterial activities against propionib ...201020045961
the role of propionibacterium acnes in acne pathogenesis: facts and controversies.we have come a long way since 1896, when it was first suggested that propionibacterium acnes, found in acne lesions, was the cause of acne. although several lines of evidence suggest the direct role of p acnes in acne, the mechanism by which p acnes contributes to the pathogenesis of acne is debated. the importance of p acnes in the induction and maintenance of the inflammatory phase of acne has been established. emerging data that inflammatory events occur in the very earliest stages of acne de ...201020082942
the role of facial sebum secretion in acne pathogenesis: facts and controversies.increased sebum secretion has been known as one of the major pathogenic factors in the development of acne; however, objective sebum measurement methods have been developed only recently. we have limited information about the association of sebum secretion, and the development of acne. there continues to be controversy about the role of sebum in the development of acne. this contribution will discuss sebum measurement techniques and the results of recent studies on the relationship of sebum, fac ...201020082943
production of cis-9,trans-11-conjugated linoleic acid in camelina meal and okara by an oat-assisted microbial process.a method to obtain cis-9,trans-11-conjugated linoleic acid (c9,t11-cla) into camelina meal and okara, the byproducts of plant oil processing, is described. the triacylglycerols in these materials were hydrolyzed with the aid of lipolytically active oat flour for 3 weeks at a water activity of 0.70. the resulting free linoleic acid was then isomerized predominantly to c9,t11-cla by resting cells of propionibacterium freudenreichii ssp. shermanii in 5% aqueous camelina meal and okara slurries. in ...201020088592
bacterial contamination of the vitreous cavity associated with transconjunctival 25-gauge microincision vitrectomy surgery.to evaluate differences in the bacterial contamination rates of the vitreous cavity between patients undergoing transconjunctival 25-gauge microincision vitrectomy surgery (mivs) and conventional 20-gauge pars plana vitrectomy (ppv).201020097429
the management of aortic stent-graft infection: endograft removal versus conservative treatment.aortic stent-graft infections (asgis) are associated with significant mortality. we report our experience of two cases of asgi treated differently and successfully.201020097522
antibacterial effects of minerals from ores indigenous to korea.we tested the antibacterial properties of a mix of minerals consisting mainly of sericite, talc, and halloysite from korea. the preparation showed clear growth inhibition of the gram-negative bacteria escherichia coli and pseudomonas aeruginosa, and the gram-positive bacteria staphylococcus aureus subsp. aureus, s. epidermidis, and bacillus cereus, as well as the anaerobic bacterium propionibacterium acnes. these results indicate that this preparation, made from ore minerals indigenous to korea, ...200920112878
propionibacterium acnes in capsular bag distension syndrome.we report a case of capsular bag distension syndrome that developed 6 years after uneventful phacoemulsification with implantation of a foldable, single-piece acrylic intraocular lens (iol) (acrysof ma60bm). slitlamp microscopy revealed a deep anterior chamber with no flare or cells. the posterior capsular bag was distended by a homogeneous milky substance between the back of the iol and the capsular bag. using a pars plana approach, a 23-gauge bimanual capsulotomy and anterior vitrectomy were p ...201020117721
massive ascites as unique sign of shunt infection by propionibacterium acnes.propionibacterium acnes (p. acnes) has been associated with shunt infection. the signs of infection are mild. we report on a case of p. acnes shunt infection presenting with massive ascites as the unique sign of csf infection. shunt removal, antibiotic therapy and drenaige of ascites were performed with a rapid clinical recovery.201020121383
ifn-gamma is a master regulator of endotoxin shock syndrome in mice primed with heat-killed propionibacterium acnes.hyper-coagulation, hypothermia, systemic inflammatory responses and shock are major clinical manifestations of endotoxin shock syndrome in human. as previously reported, mice primed with heat-killed propionibacterium acnes are highly susceptible to the action of lps to induce tumour necrosis factor (tnf)-alpha and to that of tnf-alpha to trigger lethal shock. here we investigated the mechanisms underlying the p. acnes-induced sensitization to lps and tnf-alpha and the development of individual s ...201020130231
evaluation of the antibacterial activity of rhapontigenin produced from rhapontin by biotransformation against propionibacterium acnes.biotransformation is often used to improve chemical activity. we evaluated the antimicrobial activity of rhapontigenin, converted from rhapontin after treatment with pectinex. rhapontigenin showed 4-16 times higher antimicrobial activity than rhapontin. activity was higher against gram positive strains than gram negative strains. minimum inhibitory concentrations (mics) of rhapontigenin, retinol, and five antibiotics were determined by microbroth dilution method for antibiotic-sensitive and -res ...201020134237
anterior chest wall abscess--an unusual complication of an odontogenic infection.introduction: a majority of odontogenic infections can be successfully managed with routine incision and drainage and empirical antibiotics. sometimes an odontogenic infection may spread to contiguous spaces and descend along the neck causing significant morbidity and rarely even mortality. case report: we report a case of an odontogenic infection which had an unusual spread to the anterior chest wall.201020135335
improving diagnostic criteria for propionibacterium acnes osteomyelitis: a retrospective analysis.the identification of propionibacterium acnes in cultures of bone and joint samples is always difficult to interpret because of the ubiquity of this microorganism. the aim of this study was to propose a diagnostic strategy to distinguish infections from contaminations. this was a retrospective analysis of all patient charts of those patients with >or=1 deep samples culture-positive for p. acnes. every criterion was tested for sensitivity, specificity, and positive likelihood ratio, and then the ...201020141491
biological activities of schefflera leucantha.this study investigated various biological activities of the ethanolic extract of dried ground leaves of schefflera leucantha viguier (araliaceae). the extract possessed very low cytotoxicity to brine-shrimp with the lc(50) of 4,111.15 microg/ml; the significant antioxidant activity on dpph with the ec(50) of 71.90 microg/ml; the inhibitory activity on mushroom tyrosinase with the ic(50) of 10.53 mg/ml using the dopachrome microplate-assay. the extract of 5-20 mg/ml range in the agar dilution as ...200620162087
improved diagnosis of periprosthetic joint infection by multiplex pcr of sonication fluid from removed implants.the microbiological diagnosis of periprosthetic joint infection (pji) is crucial for successful antimicrobial treatment. cultures have limited sensitivity, especially in patients receiving antibiotics. we evaluated the value of multiplex pcr for detection of microbial dna in sonication fluid from removed orthopedic prostheses. cases of pji in which the prosthesis (or part of it) was removed were prospectively included. the removed implant was sonicated, and the resulting sonication fluid was cul ...201020164283
radiant near infrared light emitting diode exposure as skin preparation to enhance photodynamic therapy inflammatory type acne treatment outcome.an alternative approach in the treatment of acne vulgaris is photodynamic therapy (pdt) that uses light and aminolevulinic acid (ala)-induced protoporphyrin ix (ppix) production to eradicate propionibacterium acnes found in acne lesions. ppix formation is dependent on ala percutaneaous penetration. in this study, to enhance ala penetration and subsequent accumulation of ppix, skin temperature was increased with radiant infrared (ir) prior to ala-pdt application and compared to ala-pdt alone in t ...201020166163
[infectious endophthalmitis after cataract extraction, a serious complication].cataract extraction with lens implantation is the most used surgical procedure worldwide and is relatively safe. nevertheless, this procedure carries the risk for infectious complications, since a foreign body is implanted in the eye to which bacteria that may cause endophthalmitis can adhere. acute postoperative endophthalmitis is a potentially devastating disease that prompts immediate recognition and therapy, whereas chronic postoperative endophthalmitis is a low virulent, long-lasting infect ...201020170580
control of escherichia coli o157:h7 in corn silage with or without various inoculants: efficacy and mode of action.this study aimed to evaluate the effectiveness of 3 commercial bacterial inoculants at controlling escherichia coli o157:h7 in corn silages during ensiling and feedout phases of silage production. a second objective was to determine whether the inoculants exhibited and transferred antibacterial activity against e. coli o157:h7 to the silages. chopped corn forage was ensiled after treatment with the following: distilled water (control); 5 x 10(5) cfu/g of e. coli o157:h7 (ec); ec and 1 x 10(6) cf ...201020172231
antimicrobial activity of long-chain (e)-3-alken-2-ones.(e)-3-tridecen-2-one, a compound identified from the interdigital glands of black-tailed deer (odocoileus hemionus columbianus), has been shown to inhibit the growth of bacteria and fungi. homologues of (e)-3-tridecen-2-one were prepared and screened for antimicrobial activity. for the fungus, trichophyton mentagrophytes, the minimum inhibitory concentration (mic) of (e)-3-tetradecen-2-one was 12.5 microg/ml, and for the bacteria, propionibacterium acnes, the mic of (e)-3-heptadecen-2-one was 3. ...201020185306
propionibacterium acnes causing delayed postoperative spine infection: review.propionibacterium acnes was previously considered a contaminant and its role in spine infection has been understated. although rare, such infections are present especially after instrumented spine surgery. they are usually delayed and hard to diagnose. delayed infection should be suspected in patients with pain and a history of spine surgery. in this article, we review the diagnostic challenges associated with delayed p. acnes infection after spine surgery, guided by relevant studies in the lite ...201020199135
a randomized, investigator-blinded trial to assess the antimicrobial efficacy of a benzoyl peroxide 5%/ clindamycin phosphate 1% gel compared with a clindamycin phosphate 1.2%/tretinoin 0.025% gel in the topical treatment of acne vulgaris.combination products in which the individual components have different mechanisms of antimicrobial action have been shown in many disease states to provide the most effective therapy.201020214175
cutaneous induction of corticotropin releasing hormone by propionibacterium acnes extracts.the skin commensal bacillus propionibacterium acnes is known to play a major role in the development of acne vulgaris and it is established that this bacteria is involved both in the induction and maintenance of the inflammatory phase of acne. the corticotropin releasing hormone (crh), a neuropeptide originally isolated from the hypothalamus, is also produced by the skin. crh has been reported to play a role in the inflammation, the production of sebum and finally the differentiation of keratino ...200920224691
correlation of the capsular phenotype in propionibacterium freudenreichii with the level of expression of gtf, a unique polysaccharide synthase-encoding gene.many food-grade bacteria produce exopolysaccharides (eps) that affect the texture of fermented food products and that may be involved in probiotic properties. propionibacterium freudenreichii is a gram-positive food-grade bacterium with reported probiotic capabilities that is widely used as starter in swiss-type cheese. in this study, 68 strains of p. freudenreichii were screened for the beta-glucan capsular phenotype by immunoagglutination with a specific antibody and for the presence of the gt ...201020228100
resolution of pigmented keratic precipitates following treatment of pseudophakic endophthalmitis caused by propionibacterium acnes.propionibacterium acnes is a well-recognized cause of chronic postoperative endophthalmitis after cataract surgery. the subtle clinical signs of this infection and its initial favorable response to topical steroids may lead to delayed diagnosis and treatment. two patients with culture proven p. acnes endophthalmitis after cataract surgery that presented with prominent pigmented keratic precipitates (kps) and low-grade iritis in the involved eye were managed. both cases had initial treatment with ...201020337310
infected giant ophthalmic artery aneurysm remnant following craniotomy for surgical clip ligation. case report.postoperative intracranial infections, although found in only a minority of surgical cases, remain a recognized potential complication following elective craniotomy. in the treatment of intracranial aneurysms, specifically, reports of significant postoperative infections are rare. significant postoperative infections are usually observed in association with foreign bodies, such as aneurysm clips, endovascular coils, or materials used for aneurysm wrapping. the authors present a case in which a p ...201020345224
effective and safe combination therapy for severe acne vulgaris: a randomized, vehicle-controlled, double-blind study of adapalene 0.1%-benzoyl peroxide 2.5% fixed-dose combination gel with doxycycline hyclate 100 mg.there is a paucity of treatment options for severe acne vulgaris aside from oral isotretinoin. this randomized, vehicle-controlled, multicenter, double-blind study evaluated the efficacy and safety of combination therapy using adapalene 0.1%-benzoyl peroxide 2.5% (a/bpo) fixed-dose combination gel with doxycycline hyclate 100 mg in the treatment of severe acne vulgaris. a total of 459 participants were randomized in a 1:1 ratio to receive oral doxycycline hyclate 100 mg once daily and either a/b ...201020349684
inhibitory effects of fortunella japonica var. margarita and citrus sunki essential oils on nitric oxide production and skin pathogens.a number of essential oils from citrus peels are claimed to have biological activities. citrus peel, called 'jin-pi', is used in traditional medicine for digestion, severe cold, and fever. however, the antibacterial activities against skin pathogens and anti-inflammatory effects of the essential oils of citrus sunki (jingyul) and fortunella japonica var. margarita (gumgyul) have not yet been described. therefore, in this study, the essential oils of the citrus species c. sunki (cse) and f. japon ...201020350876
bacterial community associated with healthy and diseased reef coral mussismilia hispida from eastern brazil.in order to characterize the bacterial community diversity associated to mucus of the coral mussismilia hispida, four 16s rdna libraries were constructed and 400 clones from each library were analyzed from two healthy colonies, one diseased colony and the surrounding water. nine bacterial phyla were identified in healthy m. hispida, with a dominance of proteobacteria, actinobacteria, acidobacteria, lentisphaerae, and nitrospira. the most commonly found species were related to the genera azospiri ...201020352207
bacterial colonization and infection of electrophysiological cardiac devices detected with sonication and swab culture.electrophysiological cardiac devices are increasingly used. the frequency of subclinical infection is unknown. we investigated all explanted devices using sonication, a method for detection of microbial biofilms on foreign bodies.201020368521
case report of acremonium intraocular infection after cataract extraction.a 64-year-old woman was referred to our clinic for the treatment of chronic uveitis in her left eye, which had started two weeks after an uncomplicated cataract extraction. she was treated with topical steroids with an initially good response, yet she subsequently developed severe inflammation and plaque-like material around the intraocular lens, despite continuous steroid therapy. she underwent pars plana vitrectomy, smear and culture of the aqueous and vitreous fluids, and intravitreal antibio ...201020379462
transdermal absorption enhancement through rat skin of gallidermin loaded in niosomes.gallidermin (gdm) loaded in anionic niosomes composed of tween 61/chl/dp (1:1:0.05 molar ratio) gave the highest entrapment efficiency (45.06%). this formulation gave antibacterial activity against propionibacterium acnes and staphylococcus aureus with the mic and mbc of 3.75 and 7.5; 7.5 and 15 microg/microl, respectively. gdm loaded in niosomes was more chemically stable than gdm in aqueous solution of about 1.5 times. gdm loaded and unloaded in niosomes were not found in the receiver solution ...201020381599
heart valve allograft decontamination with antibiotics: impact of the temperature of incubation on efficacy.heart valve allografts are typically processed at 4°c in north america, including the step of antibiotic decontamination. in our own experience with heart valve banking, we often observe persistent positive cultures following decontamination at wet ice temperature. we hypothesized that warmer temperatures of incubation might increase the efficacy of the decontamination procedure. in a first series of experiments, 12 different bacterial species were grown overnight, frozen in standardized aliquot ...201020390362
propionibacterium acnes infection induces upregulation of inflammatory genes and cytokine secretion in prostate epithelial cells.the immune stimulating bacterium propionibacterium acnes is a frequent colonizer of benign and malignant prostate tissue. to understand the pathogenesis of the earliest phase of this infection, we examined the p. acnes triggered immune response in cultivated prostate epithelial cells.201020420679
experimental pulmonary granuloma mimicking sarcoidosis induced by propionibacterium acnes in mice.propionibacterium acnes has been implicated as an etiologic agent of sarcoidosis since the isolation of this bacterium from sarcoid lesions. we experimentally produced a murine pulmonary granuloma model using p. acnes with several features that simulate sarcoidosis. mice were sensitized with heat-killed p. acnes and complete freund's adjuvant and were subsequently challenged with heat-killed p. acnes at 2-week intervals. p. acnes-challenged mice developed epitheloid cell granulomas in the lungs. ...201020424662
quantitative pcr of propionibacterium acnes dna in samples aspirated from sebaceous follicles on the normal skin of subjects with or without acne.to elucidate whether people with hair follicles containing many propionibacterium acnes cells are prone to acne, we developed a novel method to count the number of p. acnes in hair follicles. we sampled sebaceous material in hair follicles by aspiration at a constant negative pressure from the nose, forehead, and upper arm of 86 patients with acne vulgaris and 209 control subjects with healthy skin, including 84 subjects age-matched to the patients. genome-equivalents of p. acnes in samples were ...201020437767
a biofilm approach to detect bacteria on removed spinal implants.this is a prospective study comparing the diagnosis of spinal implant infection by conventional peri-implant tissue culture with a technique which uses a combination of vortexing and bath sonication to dislodge bacteria growing as a biofilm on the surface of retrieved spinal implants.201020445479
propionibacterium acidipropionici crl1198 influences the production of acids and the growth of bacterial genera stimulated by inulin in a murine model of cecal slurries.different attempts have been made to improve the health status of humans and animals by increasing the intestinal production of short-chain fatty acids (scfa) derived from non-digestible carbohydrates fermentation. in this paper we investigate the in vitro production of short-chain fatty acids (scfa) after addition of inulin, propionibacteria or a combination of both in an experimental model of mice cecal slurries. the development of bacterial genera which are usually stimulated by inulin additi ...201020451635
bacterial resistance in french acne patients.the percentage of strains of propionibacterium acnes resistant to antibiotics in acne is increasing in many countries, raising the question of the risks associated with bacterial resistance. numerous series of cases have been published on european populations of acne patients, but at the moment we still have very few data regarding france.201020465665
trends in the treatment of acne vulgaris: are measures being taken to avoid antimicrobial resistance?acne vulgaris has been treated with long-term courses of antibiotics since the 1960s. antibiotic-resistance of propionibacterium acnes (p. acnes) was first documented in the late 1970s, and, over 20 years later, the problem of antibiotic resistance still exists.201020480795
evaluation of the bact/alert 3d system for the implementation of in-house quality control sterility testing at canadian blood services.background: until recently, canadian blood services (cbs) was performing quality control sterility testing of blood components using three different processes. this study was conducted in order to standardize sterility testing at all cbs centers in a cost-effective manner using the bact/alert 3d system. methods: blood components including fresh frozen plasma, platelet concentrates, and red blood cells were inoculated with eight bacterial species at target concentrations of 1 and 10 cfu/ml. pre- ...201020482299
[systemic antibiotic therapy of acne vulgaris].inflammatory, medium to severe acne vulgaris is treated with systemic antibiotics worldwide. the rationale is an effect on propionibacterium acnes as well as the intrinsic anti-inflammatory properties of these antibiotics. although there are no correlations between the number of p. acnes and the severity of the disease, associations between the degree of humoral and cellular immune-responses against p. acnes and the severity of acne have been reported. exact data with respect to daily use of the ...201020482690
isotretinoin: state of the art treatment for acne vulgaris.summary isotretinoin (13-cis retinoic acid) is the most potent known inhibitor of sebum production. the multiple modes of action for isotretinoin, including suppression of sebaceous gland activity, normalization of the pattern of keratinization within the sebaceous gland follicle, inhibition of inflammation, reduction of growth of propionibacterium acnes in a secondary manner and, as currently shown, normalization of the expression of matrix tissue metalloproteinases and their inhibitors make th ...201020482692
[modern aspects of acne pathogenesis].acne is worldwide the most common skin disease.201020482694
[postoperative discitis due to propionibacterium acnes]. 201020493657
selective microbial aerosolization in biogas demonstrated by quantitative pcr.aerosolization of bacteria, archaea, synergistes, staphylococcus spp. and propionibacterium acnes was investigated in situ with quantitative real-time pcr of dna isolated from sludge and biogases of anaerobic digesters. the data revealed that in biogas, staphylococcus spp. and p. acnes were, respectively, aerosolized 30 and 220 times more and archaea and synergistes, respectively, 8 and 20 times less aerosolized than bacteria. this is the first demonstration of selective microbial aerosolization ...201020494574
the human nasal microbiota and staphylococcus aureus carriage.colonization of humans with staphylococcus aureus is a critical prerequisite of subsequent clinical infection of the skin, blood, lung, heart and other deep tissues. s. aureus persistently or intermittently colonizes the nares of approximately 50% of healthy adults, whereas approximately 50% of the general population is rarely or never colonized by this pathogen. because microbial consortia within the nasal cavity may be an important determinant of s. aureus colonization we determined the compos ...201020498722
anti-acne-inducing bacterial activity of mangosteen fruit rind extracts.the aims of this study were to determine the most effective solvent extract of mangosteen, anti-acne- inducing bacterial activity and the amount of alpha-mangostin, a major active component in each mangosteen fruit rind extract, using high-performance liquid chromatography (hplc).201020516704
systemic toxicity of non-cell corynebacterium parvum (cp) in monkeys.non-cell corynebacterium parvum product (ncpp) is a new preparation of corynebacterium parvum (cp), an immunomodulator that displays anticancer activities. it is prepared by nanotechnology and is intended to minimize the side effects of cp. the aim of the present study was to evaluate the immunogenicity and systemic toxicity of ncpp compared with cp in animals.201020519835
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