Publications

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brucellosis in bison, elk, and moose in elk island national park, alberta, canada. 195817649021
moose "sickness" in nova scotia-i. 195817649063
moose sickness in nova scotia. ii. 195817649069
carnivore repatriation and holarctic prey: narrowing the deficit in ecological effectiveness.the continuing global decline of large carnivores has catalyzed great interest in reintroduction to restore populations and to reestablish ecologically functional relationships. i used variation in the distribution of four holarctic prey species and their behavior as proxies to investigate the pace and intensity by which responses are lost or reinvigorated by carnivore repatriation. by simulating the presence of wolves (canis lupus), tigers (panthera tigris), and brown bears (ursus arctos) at 19 ...200717650259
patterns in the occurrence of saprophytic fungi carried by arthropods caught in traps baited with rotted wood and dung.fungi from approximately 1700 individual arthropods that had been captured in traps set in aspen-dominated woodland in western canada and baited with coyote dung, moose dung, white-rotted wood, brown-rotted wood and fiberglass were isolated in pure culture and identified. these data were analysed with principal components analysis (pca) to determine whether different types of substrate attracted specific arthropods and whether these animals carried unique assemblages of fungi with known proclivi ...200717663118
stable isotopes, ecological integration and environmental change: wolves record atmospheric carbon isotope trend better than tree rings.large-scale patterns of isotope ratios are detectable in the tissues of organisms, but the variability in these patterns often obscures detection of environmental trends. we show that plants and animals at lower trophic levels are relatively poor indicators of the temporal trend in atmospheric carbon isotope ratios (delta13c) when compared with animals at higher trophic levels. first, we tested how differences in atmospheric delta13c values were transferred across three trophic levels. second, w ...200717686730
annual variation in maternal age and calving date generate cohort effects in moose (alces alces) body mass.a general feature of the demography of large ungulates is that many demographic traits are dependent on female body mass at early ages. thus, identifying the factors affecting body mass variation can give important mechanistic understanding of demographic processes. here we relate individual variation in autumn and winter body mass of moose calves living at low density on an island in northern norway to characteristics of their mother, and examine how these relationships are affected by annual v ...200717713790
a new disease of moose. iii. 193217730848
a fossil elk or moose from the quaternary of new jersey. 188517793408
a previously unidentified chorioptes species infesting outer ear canals of moose (alces alces): characterization of the mite and the pathology of infestation.during the past decade, chorioptes mites occupying the outer ear canals have been a common finding at routine necropsies of moose (alces alces) in sweden, but neither the taxonomy of the mites nor lesions from the infestation have been investigated. in this study, the mites are characterized by morphological and molecular techniques, and the histopathology of the skin of the outer ear canal is described.200717825115
the moose in sweden. 192917830749
wolves, moose, and the allometry of population cycles.after a decade of dramatic population fluctuations, protected populations of wolves and moose in isle royale national park in lake superior returned in 1983 to the levels observed in the 1950's. inherent lags in this predator-prey system and the strong recovery of the moose population following a wolf population crash suggest that these populations may continue to cycle with a period length of about 38 (95 percent confidence interval, +/-13) years. such a long-term cycle is consistent with the p ...198417837195
wolves, moose, and tree rings on isle royale.investigation of tree growth in isle royale national park in michigan revealed the influence of herbivores and carnivores on plants in an intimately linked food chain. plant growth rates were regulated by cycles in animal density and responded to annual changes in primary productivity only when released from herbivory by wolf predation. isle royale's dendrochronology complements a rich literature on food chain control in aquatic systems, which often supports a trophic cascade model. this study p ...199417841718
amateur boxing and risk of chronic traumatic brain injury: systematic review of observational studies.to evaluate the risk of chronic traumatic brain injury from amateur boxing.200717916811
fear, human shields and the redistribution of prey and predators in protected areas.protected areas form crucial baselines to judge ecological change, yet areas of africa, asia and north america that retain large carnivores are under intense economic and political pressures to accommodate massive human visitation and attendant infrastructure. an unintended consequence is the strong modulation of the three-way interaction involving people, predators and prey, a dynamic that questions the extent to which animal distributions and interactions are independent of subtle human influe ...200717925272
climatic effects on life-history traits of moose in estonia.weather variables can influence life-history traits of ungulates. in this study, we assessed the suitability of regional climate indices including the nao and two measures of local climate-the maximal extent of ice on the baltic sea (mie) and absolute values of its annual deviations from the multi-year mean (vmie)-to examine how density-independent processes influence moose body size and fecundity. we predicted that both winter severity (large values of mie) and variability (large values of vmie ...200817943317
species barriers for chronic wasting disease by in vitro conversion of prion protein.chronic wasting disease (cwd) is a transmissible spongiform encephalopathy that can affect north american cervids (deer, elk, and moose). using a novel in vitro conversion system based on incubation of prions with normal brain homogenates, we now report that prp(cwd) of elk can readily induce the conversion of normal cervid prp (prp(c)) molecules to a protease-resistant form, but is less efficient in converting the prp(c) of other species, such as human, bovine, hamster, and mouse. however, when ...200717964288
metaanalysis of the effect of antenatal indomethacin on neonatal outcomes.the objective of the study was to determine whether indomethacin used as a tocolytic agent is associated with adverse neonatal outcomes.200717980183
giardia duodenalis cysts isolated from wild moose and reindeer in norway: genetic characterization by pcr-rflp and sequence analysis at two genes.there are few genotyping studies of giardia duodenalis isolates from cervid hosts, although a previous study suggested that cervids may be a source of infection for humans and cattle. giardia duodenalis isolates collected from wild moose (alces alces) and reindeer (rangifer tarandus) in norway during 2002 and 2003 were characterized by polymerase chain reaction-restriction fraction length polymorphism (pcr-rflp) at the beta-giardin gene, and sequence analysis at both the beta-giardin and glutama ...200717984252
traditional food attributes must be included in studies of food security in the canadian arctic.the objective was to explore some typically understudied characteristics of food security in arctic canada: observed changes to traditional food systems, perceived advantages and health benefits of traditional food and traditional food preferences.200718018844
characteristics and frequency of detection of fecal listeria monocytogenes shed by livestock, wildlife, and humans.listeria monocytogenes is a facultative intracellular pathogen that can be carried asymptomatically in various animals and can be shed in feces. we investigated the prevalence and characteristics of l. monocytogenes isolated from livestock, wildlife, and human potential sources of contamination in 2 areas in ontario, canada. from february 2003 to november 2005, a total of 268 fecal samples were collected from different animals. listeria monocytogenes was isolated using selective enrichment, isol ...200718026208
molecular characterization of the rocky mountain elk (cervus elaphus nelsoni) prnp putative promoter.chronic wasting disease (cwd) is a transmissible spongiform encephalopathy (tse) affecting deer (odocoileus spp.), moose (alces alces), and rocky mountain elk (cervus elaphus nelsoni). leucine homozygosity at elk prnp codon 132 has been associated with reduced cwd susceptibility. however, naturally acquired cwd has been detected in elk possessing the 132 leu/leu genotype. recent human and bovine studies indicate that prnp regulatory polymorphisms may also influence tse occurrence. therefore, we ...200718032463
perceived community environment and physical activity involvement in a northern-rural aboriginal community.type 2 diabetes disproportionately affects aboriginal peoples in canada. ample evidence shows that regular physical activity (pa) plays an important role in the prevention and treatment of type 2 diabetes. evidence is beginning to emerge linking pa to the physical environment but little is known about the relationship between remote rural environments and pa involvement in aboriginal peoples. this study's purpose was to investigate the relationship between perceptions of the environment and pa a ...200718053217
factors associated with a second hip fracture: a systematic review.to provide a systematic review of factors associated with subsequent hip fracture among individuals who have fractured a hip.200818057086
dynamics of a discrete population model for extinction and sustainability in ancient civilizations.we analyze a discrete version of a recently developed ratio dependent population-resource model. this model has been used to study the decline of the human and resource populations on easter island and the chaotic dynamics of moose and wolf populations in canada. the dynamical system exhibits a rich behavior of fractal basins of attraction and a neimark-sacker bifurcation route to chaos. the model consists of a coupled pair of logistic equations, with the carrying capacity for the predators prop ...200818157926
canadian-acquired hydatid disease: a case report.echinococcal cysts are unusual in canada, and most cases seen are in immigrants. in northern canadian communities, echinococcus granulosis infection occasionally is acquired from dogs that feed on the entrails of caribou or moose. seventeen patients with canadian-acquired hydatid cysts were seen over an 11-year period. one challenging case is described in detail. an 18-year-old aboriginal woman presented with jaundice, pain, lower extremity edema and coagulopathy from a 26 cm echinococcal hepati ...200118159337
environmental tobacco smoke and fetal health: systematic review and meta-analysis.to determine the effects of environmental tobacco smoke (ets) exposure on birth outcomes.200818218658
[traditional concept of madness and therapeutic difficulties in the moose of kadiogo.].the practice of psychiatry in the south of the sahara in africa collides with many problems of acceptability of care for the ill and their families. the frequent rejection of the psychiatrist's therapeutic approach can often be explained by the inadaptation of the etiopathogenic approach. indeed, in black africa, responsibility of illness differs according to the fact that one has been schooled or not. the western world teaches minorities having the chance to live there or learn about it, that t ...199818253558
first report of echinococcus granulosus g8 in eurasia and a reappraisal of the phylogenetic relationships of 'genotypes' g5-g10.in this study, we investigated the presence of the larval stage of the tapeworm echinococcus granulosus in wild ungulates in estonia, genetically characterized e. granulosus isolates using mitochondrial gene sequences and used the sequence data, together with those available in a public database, to infer the phylogenic relationships of e. granulosus 'genotypes' g5-g10. while 0.8% of the 2038 moose (alces alces) examined were found to be infected with e. granulosus, the parasite was not detected ...200818261256
summer kill rates and predation pattern in a wolf-moose system: can we rely on winter estimates?so far the vast majority of studies on large carnivore predation, including kill rates and consumption, have been based on winter studies. because large carnivores relying on ungulates as prey often show a preference for juveniles, kill rates may be both higher and more variable during the summer season than during the rest of the year leading to serious underestimates of the total annual predation rate. this study is the first to present detailed empirical data on kill rates and prey selection ...200818270746
a systematic review of the accuracy and utility of early markers of ifosfamide-induced proximal tubulopathy in survivors of childhood cancers.this study was conducted to identify and assess the accuracy and utility of any early markers of clinically significant proximal tubulopathy in children treated with ifosfamide chemotherapy. ifosfamide is widely used either as a solitary agent or in conjunction with various other chemotherapeutic agents in treating solid tumors of childhood. it is highly effective but can cause short-term and long-term damage to kidneys, most commonly resulting in a tubular nephropathy and/or glomerular dysfunct ...200818363176
sarcocystis in moose (alces alces): molecular identification and phylogeny of six sarcocystis species in moose, and a morphological description of three new species.muscle tissues from 34 moose from southeastern norway and two moose from canada were examined. sarcocysts were excised and morphologically classified by light microscopy, and some cysts were further examined by scanning electron microscopy or dna amplification and sequencing at the small subunit (ssu) rrna gene. in norwegian moose, three sarcocyst types were recognized, yet five sarcocystis species were found by sequence analysis. new names were proposed for three species which could be characte ...200818369663
enzyme-assisted synthesis and structure characterization of glucuronic acid conjugates of losartan, candesartan, and zolarsartan.three angiotensin ii receptor antagonists--losartan, candesartan, and zolarsartan--were investigated. all the compounds, which are structural analogues, are metabolized via conjugation to glucuronic acid. interestingly, both o- and n-glucuronidation take place, so that regioisomers are formed. one ether o-glucuronide, two acyl o-glucuronides, and five tetrazole-n-glucuronides were biosynthesized, in milligram scale, from the three sartan aglycones. liver microsomes from bovine, moose, rat, and p ...200818378273
a prion disease of cervids: chronic wasting disease.chronic wasting disease (cwd) is a prion disease of deer, elk, and moose, initially recognized in colorado mule deer. the discovery of cwd beyond the borders of colorado and wyoming, in canada and as far east as new york, has led to its emergence as a prion disease of international importance. epidemiological studies indicate that cwd is horizontally transmitted among free-ranging animals, potentially indirectly by prion-containing secreta or excreta contaminating the environment. experimental c ...200818381058
q fever presenting as recurrent, culture-negative endocarditis with aortic prosthetic valve failure: a case report and review of the literature.the present report describes a case of recurrent, culture-negative endocarditis presenting with aortic prosthetic valve dysfunction in a 62-year-old man who required four valve replacement surgeries. on each occasion, he presented with valve failure. fever was only documented during his first presentation. furthermore, no vegetations were detectable on his aortic valve at transesophageal echocardiography. on the occasion of his most recent presentation, a detailed history of animal exposure - in ...200618382649
experimental chronic wasting disease (cwd) in the ferret.chronic wasting disease (cwd), a prion disease of north american deer, elk and moose, affects both free-ranging and captive cervids. the potential host range for cwd remains uncertain. the susceptibility of the ferret to cwd was examined experimentally by administering infectious brain material by the intracerebral (ic) or oral (po) route. between 15 and 20 months after ic inoculation, ferrets developed neurological signs consistent with prion disease, including polyphagia, somnolence, piloerect ...200818387626
[evidence based public health: resources on effectiveness of community interventions].the evaluation of interventions in public health is a key element through the process of developing health policies, but it is not free of controversy. for doing this purpose it is essential the use of research outcomes, although there are sticking points related to the traditional approach of evidence based medicine, dominated by the randomized clinical trial as the gold standard. not always it is possible to develop randomized and controlled studies in public health (sometimes due to ethical l ...200818398548
an approach toward understanding wildlife-vehicle collisions.among the most conspicuous environmental effects of roads are vehicle-related mortalities of wildlife. research to understand the factors that contribute to wildlife-vehicle collisions can be partitioned into several major themes, including (i) characteristics associated with roadkill hot spots, (ii) identification of road-density thresholds that limit wildlife populations, and (iii) species-specific models of vehicle collision rates that incorporate information on roads (e.g., proximity, width, ...200818427884
the first record of elaphostrongylus alces larvae in moose in poland and their development to the invasive stage.this is the first record of the first stage larvae of elaphostrongylus alces in moose in poland.200718441880
breastfeeding among the ontario james bay cree: a retrospective study.although previous unpublished research has demonstrated low breastfeeding rates among the james bay cree of northern ontario, the reasons for this are not immediately clear.201318457281
the scale-dependent impact of wolf predation risk on resource selection by three sympatric ungulates.resource selection is a fundamental ecological process impacting population dynamics and ecosystem structure. understanding which factors drive selection is vital for effective species- and landscape-level management. we used resource selection probability functions (rspfs) to study the influence of two forms of wolf (canis lupus) predation risk, snow conditions and habitat variables on white-tailed deer (odocoileus virginianus), elk (cervus elaphus) and moose (alces alces) resource selection in ...200818481095
the moose throat bot fly cephenemyia ulrichii larvae (diptera: oestridae) found developing in roe deer (capreolus capreolus) for the first time.about fifty larvae of cephenemyia ulrichii brauer (diptera: oestridae), some of them nearly full-grown third instars, were found in the throat of a roe deer (capreolus capreolus) in june 2007 near helsinki in finland. the parasite is considered to be host specific, occurring only in the moose (alces alces), and this paper is apparently the first report of a successful infestation in an aberrant host.200818518973
spatial patterns of polybrominated diphenyl ethers (pbdes) in mosses, herbivores and a carnivore from the norwegian terrestrial biota.the widespread occurrence of polybrominated diphenyl ethers (pbdes) in the environment has attracted considerable attention, leading to concerns about the extent and magnitude of wildlife and human exposure. in this work, we focus on the occurrence and fate of pbdes in a norwegian air-plant-herbivore-carnivore system. specifically, we have analysed for pbdes in moss, livers from various terrestrial herbivores (moose, grouse, and european roe deer) and, for the first time, livers from the top pre ...200818627904
diet shift of a facultative scavenger, the wolverine, following recolonization of wolves.1. wolves canis lupus l. recolonized the boreal forests in the southern part of the scandinavian peninsula during the late 1990s, but so far there has been little attention to its effect on ecosystem functioning. wolf predation increases the availability of carcasses of large prey, especially moose alces alces l., which may lead in turn to a diet switch in facultative scavengers such as the wolverine gulo gulo l. 2. using 459 wolverine scats collected during winter-spring 2001-04 for dna identit ...200818657209
systematic review of orogenital hiv-1 transmission probabilities.the objective was to assess the risk of hiv transmission from orogenital intercourse (oi).200818664564
the human udp-glucuronosyltransferase ugt1a3 is highly selective towards n2 in the tetrazole ring of losartan, candesartan, and zolarsartan.losartan, candesartan, and zolarsartan are at(1) receptor antagonists that inhibit the effect of angiotensin ii. we have examined their glucuronidation by liver microsomes from several animals and by recombinant human udp-glucuronosyltransferases (ugts). large differences in the production of different glucuronide regioisomers of the three sartans were observed among liver microsomes from human (hlm), rabbit, rat, pig, moose, and bovine. however, all the liver microsomes produced one or two n-gl ...200818674515
endovenous therapies of lower extremity varicosities: a meta-analysis.minimally invasive techniques such as endovenous laser therapy, radiofrequency ablation, and ultrasound-guided foam sclerotherapy are widely used in the treatment of lower extremity varicosities. these therapies have not yet been compared with surgical ligation and stripping in large randomized clinical trials.200918692348
moose consort strobe and miame stard remark or how can we improve the quality of reporting studies. 200818728905
the overlap model: a model of letter position coding.recent research has shown that letter identity and letter position are not integral perceptual dimensions (e.g., jugde primes judge in word-recognition experiments). most comprehensive computational models of visual word recognition (e.g., the interactive activation model, j. l. mcclelland & d. e. rumelhart, 1981, and its successors) assume that the position of each letter within a word is perfectly encoded. thus, these models are unable to explain the presence of effects of letter transposition ...200818729592
cadmium in moose kidney and liver--age and gender dependency, and standardisation for environmental monitoring.in the northern hemisphere moose has been found to be suitable as a monitoring animal for the presence of cadmium in the environment. the metal accumulates mainly in the kidney and the liver, with the rate of accumulation dependent on age and possibly also on gender. collection of tissue material often results in sample selections with disparate age and gender composition, which makes comparison between different regions and different studies difficult. a previous large scale investigation of me ...200918758976
persistent bovine viral diarrhea virus infection in wild cervids of colorado.bovine viral diarrhea virus (bvdv) is a significant viral pathogen of domestic cattle. worldwide, there is evidence of bvdv exposure and infection in wild ungulates; however, the frequency and significance of such events are unknown. to determine the prevalence and distribution of colorado deer, elk, and moose persistently infected (pi) with bvdv, a cross-sectional study was conducted using full-thickness ear tissue samples collected from animals presented to the colorado division of wildlife fo ...200818776103
acute yew (taxus) poisoning in moose (alces alces).acute yew (taxus) intoxication in a free-ranging moose (alces alces) is reported. the moose was found dead without any signs of struggle and post mortem examination revealed general congestion, bilateral heart dilatation, and the presence of yew in rumen. the animal was found adjacent to a housing estate with unfenced gardens, surrounded by woods and open fields without native yew. the vast majority of the gardens contained cultivars of yew that had frequently been browsed upon. these were the m ...200818793664
setaria tundra microfilariae in reindeer and other cervids in finland.harmful parasites of the wild northern boreal mammals are still surprisingly poorly studied. in 2003-2006, a peritonitis outbreak caused by the filarioid nematode, setaria tundra, emerged in finland's reindeer population. in order to gain knowledge about the basic biology, epidemiology, and transmission dynamics of this parasite, samples for s. tundra were collected from reindeer and other cervids during the follow-up period 2004-2006. using morphology and molecular biology methods, we describe ...200918810493
lack of compensatory body growth in a high performance moose alces alces population.considerable work has been done on disentangling important factors determining early development in body size, yet our knowledge of the extent to which animals living under varying conditions can achieve catch-up growth for a bad start in life is limited. here, we investigated how body mass at the age of 8 months influenced adult body mass in a moose alces alces population living under excellent environmental conditions on the island of vega in northern norway. we also investigated if mother age ...200818830632
revisiting the classics: considering nonconsumptive effects in textbook examples of predator-prey interactions.predator effects on prey dynamics are conventionally studied by measuring changes in prey abundance attributed to consumption by predators. we revisit four classic examples of predator-prey systems often cited in textbooks and incorporate subsequent studies of nonconsumptive effects of predators (nce), defined as changes in prey traits (e.g., behavior, growth, development) measured on an ecological time scale. our review revealed that nce were integral to explaining lynx-hare population dynamics ...200818831163
population structure and genetic diversity of moose in alaska.moose (alces alces) are highly mobile mammals that occur across arboreal regions of north america, europe, and asia. alaskan moose (alces alces gigas) range across much of alaska and are primary herbivore consumers, exerting a prominent influence on ecosystem structure and functioning. increased knowledge gained from population genetics provides insights into their population dynamics, history, and dispersal of these unique large herbivores and can aid in conservation efforts. we examined the ge ...200918836148
amateur boxing and risk of chronic traumatic brain injury: systematic review of observational studies.to evaluate the risk of chronic traumatic brain injury from amateur boxing.200818988761
large herbivores and aquatic-terrestrial links in southern boreal forests.1. concurrent measurement of population dynamics and associated spatio-temporal patterns of resource flow across aquatic-terrestrial boundaries are rare, yet necessary to understand the consequences of cross-habitat resource flux. long-term study of the moose alces alces (l.) population in isle royale national park (lake superior, usa) provides an opportunity to examine the patterns of resource flux from aquatic to terrestrial habitats over approximately50 years. 2. we analysed the spatio-tempor ...200919021781
traditional foods and physical activity patterns and associations with cultural factors in a diverse alaska native population.to determine the prevalence of traditional food and physical activity use and associations with cultural factors among 3,830 alaska native and american indian (an/ai) people enrolled in the education and research towards health (earth) study in 3 regions of alaska.200819024803
physical characteristics of rumen contents in four large ruminants of different feeding type, the addax (addax nasomaculatus), bison (bison bison), red deer (cervus elaphus) and moose (alces alces).based on morphological and physiological observations, it has been suggested that differences exist in the degree that reticuloruminal (rr) contents are stratified between various ruminant species. however, the occurrence of stratification has hardly been measured in non-domestic species. forestomach contents of free-ranging moose (n=22) and red deer (24) shot during regular hunting procedures, and of captive (but 100% forage fed) addax (6) and bison (10) culled for commercial or management purp ...200919049897
sarcocystis in norwegian roe deer (capreolus capreolus): molecular and morphological identification of sarcocystis oviformis n. sp. and sarcocystis gracilis and their phylogenetic relationship with other sarcocystis species.fresh muscle tissue from six roe deer from southeastern norway was examined for sarcocysts. cysts were excised and morphologically classified by light microscopy, and some cysts were further examined by scanning electron microscopy or dna amplification and sequencing of the small subunit (ssu) rrna gene. two sarcocystis species, sarcocystis gracilis and sarcocystis oviformis n. sp., were found and described by morphological and molecular methods. s. gracilis was found in all animals, whereas s. ...200919050921
age, size, and spatiotemporal variation in ovulation patterns of a seasonal breeder, the norwegian moose (alces alces).in seasonal environments, timing of reproduction is an important fitness component. however, in ungulates, our understanding of this biological process is limited. here we analyze how age and body mass affect spatiotemporal variation in timing of ovulation of 6,178 norwegian moose. we introduced a parametric statistical model to obtain inferences about the seasonal timing of ovulation peak, the degree of synchrony among individuals, and the proportion of individuals that ovulate. these component ...200919072136
microbial thiosulphate reaction arrays: the interactive roles of fe(iii), o2 and microbial strain on disproportionation and oxidation pathways.in this work, we experimentally evaluate ph and so4(2-) dynamics associated with abiotic and microbial s2o3(2-) oxidation under varying [o2], [fe(iii)] and microbial strain/consortia (two pure strains, acidithiobacillus ferrooxidans, acidithiobacillus thiooxidans, their consortia, and two enrichments from an acidic environmental system, moose lake 2002 and moose lake 2003). results of the batch experiments demonstrate highly active microbial processing of s2o3(2-) while abiotic controls under id ...200819076637
transfer parameter values in temperate forest ecosystems: a review.compared to agricultural lands, forests are complex ecosystems as they can involve diverse plant species associations, several vegetative strata (overstorey, shrubs, herbaceous and other annual plant layer) and multi-layered soil profiles (forest floor, hemi-organic and mineral layers). a high degree of variability is thus generally observed in radionuclide transfers and redistribution patterns in contaminated forests. in the long term, the soil compartment represents the major reservoir of radi ...200919100665
pymoose: interoperable scripting in python for moose.python is emerging as a common scripting language for simulators. this opens up many possibilities for interoperability in the form of analysis, interfaces, and communications between simulators. we report the integration of python scripting with the multi-scale object oriented simulation environment (moose). moose is a general-purpose simulation system for compartmental neuronal models and for models of signaling pathways based on chemical kinetics. we show how the python-scripting version of m ...200819129924
strega, strobe, stard, squire, moose, prisma, gnosis, trend, orion, coreq, quorom, remark... and consort: for whom does the guideline toll? 200919181482
sheep-associated malignant catarrhal fever in free-ranging moose (alces alces) in saskatchewan, canada.malignant catarrhal fever (mcf) is a sporadic disease of artiodactyls caused by several viruses in the gammaherpesvirinae. we report two cases of mcf in free-living moose (alces alces) from saskatchewan. one was a thin, dehydrated, adult male found recumbent in 2006. at necropsy, ulcers were found in the intestine, bladder, and corneas. microscopically, there was lymphocytic vasculitis and perivasculitis in many organs with infrequent fibrinoid necrosis. ovine herpes virus-2 (ohv-2) was identifi ...200919204352
polychlorinated dibenzo-p-dioxins, dibenzofurans, and polychlorinated biphenyls in semi-domesticated reindeer (rangifer tarandus tarandus) and wild moose (alces alces) meat in finland.semi-domesticated reindeer and wild moose meat samples were analyzed for polychlorinated dibenzo-p-dioxins and dibenzofurans (pcdd/fs), and polychlorinated biphenyls (pcbs). both calves and adults were studied. individual reindeer and moose meat samples and pooled reindeer calf meat samples were collected from the northern, the middle, and the southern reindeer herding regions in finland. samples represented the edible parts of carcasses. in individual samples of reindeer the fat based who-pcdd/ ...200919217140
detection of cwd prions in urine and saliva of deer by transgenic mouse bioassay.chronic wasting disease (cwd) is a prion disease affecting captive and free-ranging cervids (e.g. deer, elk, and moose). the mechanisms of cwd transmission are poorly understood, though bodily fluids are thought to play an important role. here we report the presence of infectious prions in the urine and saliva of deer with chronic wasting disease (cwd). prion infectivity was detected by bioassay of concentrated, dialyzed urine and saliva in transgenic mice expressing the cervid prp gene (tg[cerp ...200919293928
influence of soil acidification in southern norway on the 137cs exposure of moose?the mean (137)cs activity concentration in 278 liver samples of moose (alces alces) from 16 municipalities located in different parts of norway varied within the range 43-752 bq kg(-1) among the municipalities. in general the geographical variation corresponded to the fallout pattern produced by the chernobyl accident. in three communities in the southernmost part of the country however the transfer factor, defined as the activity in moose liver divided by the corresponding level in surface soil ...200919303135
even-toed but uneven in length: the digits of artiodactyls.in captive ruminants housed in small enclosures, hypertrophy of the outer hooves of the hindlimbs is often observed. we hypothesised that the underlying cause is overload attributable to an asymmetry of the digits, especially with respect to their length. to test this hypothesis, the bones of the digits of four species of artiodactyls, which included 11 wild chamois (rupicapra rupicapra), 11 captive fallow deer (dama dama), 11 captive bison (bison bison) and 11 european moose (alces alces; 9 wil ...200919386479
dermoid cysts in caribou.subcutaneous dermoid cysts were identified in eight wild caribou (rangifer tarandus) from widely dispersed locations in northern canada and in one wild caribou from alaska. the dermoid cysts from canadian caribou were found among 557 diagnostic specimens that had been detected by hunters and submitted by resource officers and biologists between 1 january 1966 and 15 may 2007. all of the cysts were located in the cervical region, and five of nine cysts were found in the throat area. all of the an ...200919395761
association between antioxidant vitamins and asthma outcome measures: systematic review and meta-analysis.epidemiological studies suggest that dietary intake of vitamins a, c and e may be associated with the occurrence of asthma. a systematic review and meta-analysis was conducted in accordance with moose guidelines to determine whether vitamins a, c and e, measured as dietary intakes or serum levels, are associated with asthma.200919406861
management of bartholin duct cysts and abscesses: a systematic review.to review systematically the literature, published in english, on recurrence and healing after treatment of bartholin duct cysts and abscesses.200919445813
synthesis, structure characterization, and enzyme screening of clenbuterol glucuronides.two clenbuterol o-glucuronide diastereomers were synthesized by the koenigs-knorr reaction. structures and glucuronidation sites of the glucuronides were characterized by tandem mass spectrometry and nuclear magnetic resonance spectroscopy. the two diastereomers were used as standard compounds in studies of stereoselective glucuronidation of clenbuterol with liver microsomes from different species and with 15 human recombinant udp-glucuronosyltransferases. in this study, chemical and enzymatic r ...200919447177
no 'bypass' in adult ruminants: passage of fluid ingested vs. fluid inserted into the rumen in fistulated muskoxen (ovibos moschatus), reindeer (rangifer tarandus) and moose (alces alces).in young ruminants, the reticular groove ensures that ingested milk is channelled past the forestomach to avoid malfermentation. it has been speculated that some adult wild ruminants, in particular browsing species, maintain a functional oesophageal (reticular) groove, that soluble nutrients can thus bypass the rumen, and that thus the energetic gain from the diet can be increased. we inserted a fluid marker (co-edta) via cannula into the rumen and simultaneously fed a diet that contained a seco ...200919497382
summer dietary nitrogen availability as a potential bottom-up constraint on moose in south-central alaska.recent studies suggest that the growth and fecundity of northern ungulates may be coupled to their summer nutrition. here, we compare summer dietary nitrogen availability of the five major browse plants (comprising approximately 79% of the diet) of moose (alces alces) in denali national park and nelchina basin, alaska, usa. in recent years the productivity of denali moose has been significantly higher than that of nelchina moose, prompting this comparison. we examined the phenological progressio ...200919537559
the roles of predator maturation delay and functional response in determining the periodicity of predator-prey cycles.population cycles in small mammals have attracted the attention of several generations of theoretical and experimental biologists and continue to generate controversy. top-down and bottom-up trophic regulations are two recent competing hypotheses. the principal purpose of this paper is to explore the relative contributions of a variety of ecological factors to predator-prey population cycles. here we suggest that for some species - collared lemmings, snowshoe hares and moose in particular - matu ...200919563815
preterm birth and low birth weight among in vitro fertilization singletons: a systematic review and meta-analyses.our objective was to determine the risks of preterm birth (ptb) and low birth weight (lbw) in singletons conceived through in vitro fertilization (ivf)+/-intracytoplasmic sperm injection (icsi) compared to spontaneously conceived singletons after matching or controlling for at least maternal age. the moose guidelines for meta-analysis of observational studies were followed. medline and embase were searched using comprehensive search strategies. bibliographies of identified articles were reviewed ...200919577836
[meta-analysis on the correlation of cholecystectomy or cholecystolithiasis to risk of colorectal cancer in chinese population].it is reported that the incidence of colorectal cancer is higher in patients receiving cholecystectomy (che) than in those who did not. however, the correlation of che and cholecystolithiasis (cho) to colorectal cancer is unclear. this study was to investigate the correlation of che or cho to risk of colorectal cancer in chinese population.200919624904
geographical variation in the influence of density dependence and climate on the recruitment of norwegian moose.the effects of variation in climate on population dynamics are likely to differ within the distributional range of a species, yet the consequences of such regional variation on demography and population dynamics are rarely considered. here we examine how density dependence and different climate variables affect spatio-temporal variation in recruitment rates of norwegian moose using data collected over a large geographical area during the hunting season. after accounting for observation error by ...200919657678
conception date affects litter type and foetal sex ratio in female moose in estonia.1. the trivers-willard model of optimal sex ratios predicts that in polygynous species mothers in better condition should produce more male than female offspring. however, empirical support for this hypothesis in mammals and especially ungulates has been equivocal. this may be because the fitness of mothers has been defined in different ways, reflecting morphological, physiological or behavioural measures of condition. in addition, factors other than maternal condition can influence a mother's f ...201019682139
schizophrenia and breast cancer incidence: a systematic review of clinical studies.studies examining the incidence of breast cancer in schizophrenia patients report increased, reduced or similar incidence compared to the general population. we undertook a systematic review of published data to investigate possible reasons for the variable findings.200919695837
experiments on the ectoparasitic deer ked that often attacks humans; preferences for body parts, colour and temperature.the deer ked (lipoptena cervi) can fail in its host search. host search fails when an individual deer ked irreversibly accepts a host unsuitable for its reproduction (e.g. a human) and drops its wings. in northern europe, the main host of the deer ked is the moose (alces alces). the deer ked is increasingly causing serious problems for humans (for example, causing deer ked dermatitis) and is considered a threat for the recreational use of forests. the adult deer ked flies in early and mid-autumn ...201019698197
dna repair gene polymorphisms and risk of cutaneous melanoma: a systematic review and meta-analysis.polymorphisms of dna repair-related genes might modulate cancer predisposition. we performed a systematic review and meta-analysis of the available evidence regarding the relationship between these polymorphisms and the risk of developing cutaneous melanoma. relevant studies were searched using pubmed, medline, embase, cancerlit, cochrane and isi web of knowledge databases. data were gathered according to the meta-analysis of observational studies in epidemiology (moose) guidelines. the model-fr ...200919706646
the effectiveness of hysteroscopy in improving pregnancy rates in subfertile women without other gynaecological symptoms: a systematic review.although hysteroscopy is frequently used in the management of subfertile women, a systematic review of the evidence on this subject is lacking.200919744944
hunting with lead: association between blood lead levels and wild game consumption.wild game hunting is a popular activity in many regions of the united states. recently, the presence of lead fragments in wild game meat, presumably from the bullets or shot used for hunting, has raised concerns about health risks from meat consumption.200919747676
systematic reviews of adverse effects of drug interventions: a survey of their conduct and reporting quality.there is a need for high quality evidence on the adverse effects of medical interventions to inform policy, practice and research. methods to systematically review adverse effects have not been fully developed. we aimed to assess the current methods and reporting used by such reviews.200919757414
periodontal diseases and cardiovascular events: meta-analysis of observational studies.many studies have investigated the relationship between periodontal and cardiovascular diseases but their results are heterogeneous. meta-analyses were conducted to examine the association between exposure to periodontitis and cardiovascular diseases.200919774803
outcome of shoulder hemiarthroplasty in acute proximal humeral fractures: a frustrating meta-analysis experience.limited evidence is available on the optimal treatment of complex fractures of the proximal humerus. no randomized prospective studies have compared hemiarthroplasty, open reduction internal fixation and/or conservative treatment. two systematic reviews are available but they do not include angle-stable plate osteosynthesis or third-generation prosthetic designs. we conducted a systematic review of studies published in the last 10 years. the moose guidelines were followed and we focused on funct ...200919774809
evidence-based medicine, systematic reviews, and guidelines in interventional pain management: part 6. systematic reviews and meta-analyses of observational studies.observational studies provide an important source of information when randomized controlled trials (rcts) cannot or should not be undertaken, provided that the data are analyzed and interpreted with special attention to bias. evidence-based medicine (ebm) stresses the examination of evidence from clinical research and describes it as a shift in medical paradigm, in contrast to intuition, unsystematic clinical experience, and pathophysiologic rationale. while the importance of randomized trials h ...201119787009
susceptibilities of nonhuman primates to chronic wasting disease.chronic wasting disease (cwd) is a transmissible spongiform encephalopathy, or prion disease, that affects deer, elk, and moose. human susceptibility to cwd remains unproven despite likely exposure to cwd-infected cervids. we used 2 nonhuman primate species, cynomolgus macaques and squirrel monkeys, as human models for cwd susceptibility. cwd was inoculated into these 2 species by intracerebral and oral routes. after intracerebral inoculation of squirrel monkeys, 7 of 8 cwd isolates induced a cl ...200919788803
maternal and fetal outcome in women with type 2 versus type 1 diabetes mellitus: a systematic review and metaanalysis.glycemic disturbance is usually less severe in pregnant women with type 2 than in those with type 1 diabetes mellitus (dm). nevertheless, a worse perinatal outcome in women with type 2 dm has been reported in some studies.200919808847
checklists to improve the quality of the orthopaedic literature.several checklists have been developed in an effort to help journals and researchers improve the quality of reporting in research. the consort statement and the clear npt evaluate randomized trials. the moose and quorom checklists evaluate meta-analyses. the strobe checklists assists readers in evaluating observational studies and the stard checklist was developed for diagnostic test evaluation. the checklists presented here provide an invaluable source of guidance to authors, journal editors an ...200819826520
organization of the chemosensory neuroepithelium of the vomeronasal organ of the scandinavian moose alces alces.a functional vomeronasal organ is present in most land-living vertebrates, but not in all. studies in a limited number of mammals have shown that stimulation of the vomeronasal neurons by odorous cues from conspecifics can lead to changes in innate behaviors in association to e.g. mating and aggression. given the role of the organ in detecting odorous molecules important for species-specific communication, investigations of the structure of the vomeronasal organ within the mammalian group are wa ...201019833105
preterm birth and low birth weight among in vitro fertilization twins: a systematic review and meta-analyses.the objective of this systematic review and meta-analyses was to determine the risks of preterm birth (ptb) and low birth weight (lbw) in twins conceived through in vitro fertilization (ivf) or ivf/intracytoplasmic sperm injection (icsi) compared to spontaneously-conceived twins after matching or controlling for at least maternal age.201019833428
plasma lactate concentrations in free-ranging moose (alces alces) immobilized with etorphine.to investigate plasma lactate concentrations of etorphine-immobilized moose in relation to environmental, temporal and physiological parameters.200919845927
postmortal radiographic diagnosis of laminitis in a captive european moose (alces alces).a five year-old bull moose (alces alces) was culled due to chronic hoof overgrowth that required frequent intervention. radiographic examination revealed changes in phalangeal bone structure usually considered indicative for laminitis in domestic cattle; similar changes were absent in the hooves of a free-ranging moose of similar age. the captive animal had been maintained in exhibits whose flooring were much harder than the soil in natural moose habitat, and on a diet with a high proportion of ...200919885800
depression of belowground respiration rates at simulated high moose population densities in boreal forests.large herbivores can affect the carbon cycle in boreal forests by changing productivity and plant species composition, which in turn could ultimately alter litter production, nutrient cycling, and the partitioning between aboveground and belowground allocation of carbon. here we experimentally tested how moose (alces alces) at different simulated population densities affected belowground respiration rates (estimated as co2 flux) in young boreal forest stands situated along a site productivity gr ...200919886482
differential passage of fluids and different-sized particles in fistulated oxen (bos primigenius f. taurus), muskoxen (ovibos moschatus), reindeer (rangifer tarandus) and moose (alces alces): rumen particle size discrimination is independent from contents stratification.ruminant species differ in the degree that their rumen contents are stratified but are similar insofar that only very fine particles are passed from the forestomach to the lower digestive tract. we investigated the passage kinetics of fluid and particle markers (2, 10 and 20 mm) in fistulated cattle (bos primigenius f. taurus), muskoxen (ovibos moschatus), reindeer (rangifer tarandus) and moose (alces alces) on different diets. the distribution of dry matter in the rumen and the viscosity of rum ...201019896552
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