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swainsonine inhibits growth and potentiates the cytotoxic effect of paclitaxel in hepatocellular carcinoma in vitro and in vivo.swainsonine, an extract from astragalus membranaceus, exhibits broad inhibition of growth and pro-apoptotic activity in a number of tumor types. however, the underlying mechanism involved remains unclear. to investigate the effects and mechanisms of swainsonine on hepatocellular carcinoma (hcc), we performed experiments on hepg2, smcc7721, huh7 and mhcc97-h human hepatoma and hl-7702 human hepatocyte cells. we observed that swainsonine significantly inhibited the viability of human hepatoma cell ...201222993037
[expression of inducible nitric oxide synthase in restenosis rats and function of astragalus membranaceus and angelica sinensis].to explore the expression of inducible nitric oxide synthase (inos) in restenosis rats and function of astragalus membranaceus and angelica sinensis.201222994002
astragalus polysaccharides enhance immune responses of hbv dna vaccination via promoting the dendritic cell maturation and suppressing treg frequency in mice.astragalus polysaccharides (aps), an extract from a kind of chinese traditional herb astragalus membranaceus, was proved to have strong immunoregulatory properties. in this study, aps was employed as an adjuvant of hepatitis b virus (hbv) dna vaccine (pcds2) and its' effects on immune system of mice were investigated. our data demonstrated that aps as an adjuvant could increase the hbsag-specific antibody level as well as the proliferating activity of t cells. aps also could induce cd4(+) t cell ...201223006659
novel anti-angiogenic effects of formononetin in human colon cancer cells and tumor xenograft.formononetin is a novel herbal isoflavonoid isolated from astragalus membranaceus, a medicinal plant that possesses antitumorigenic properties. our previous findings demonstrated that formononetin initiates growth-inhibitory and pro-apoptotic activities in human colon cancer cells. in the present study, we aimed to further examine the potential of formononetin in controlling angiogenesis and tumor cell invasiveness in human colon cancer cells and tumor xenografts. the results showed that formono ...201223023137
therapeutic effects of astragaloside iv on myocardial injuries: multi-target identification and network analysis.astragaloside iv (ags-iv) is a main active ingredient of astragalus membranaceus bunge, a medicinal herb used for cardiovascular diseases (cvd). in this work, we investigated the therapeutic mechanisms of ags-iv at a network level by computer-assisted target identification with the in silico inverse docking program (invdock). targets included in the analysis covered all signaling pathways thought to be implicated in the therapeutic actions of all cvd drugs approved by us fda. a total of 39 putat ...201223028693
effect of a derived herbal recipe from an ancient chinese formula, danggui buxue tang, on ovariectomized rats.radix astragali (root of astragalus membranaceus (fisch.) bge. var. mongholicus (bge.) hsiao, ra), radix angelicae sinensis (root of angelica sinensis (oliv.) diels, ras) and folium epimedii (leaves of epimedium brevicomum maxim., fe) are three of the extensively applied herbal remedies among traditional chinese medicines for gynecological disorders and osteoporosis. a derivative herbal recipe-rrf, composed of the three medicines with a weight ratio of 5:1:5, is derived from a famous chinese her ...201223036809
[effects of the combination of active component extracts from astragalus membranaceus and panax notoginseng on apoptosis, reactive oxygen species and mitochondrial membrane potential of pc12 cells with oxidative injury].to explore the effects and mechanisms of combining astragaloside iv (the effective component of astragalus membranaceus) with notoginsenoside r1, ginsenoside rb1 and ginsenoside rg1 (the effective components of panax notoginseng) against oxidative injury in pc12 cells induced by cobalt chloride (cocl₂).201223073196
effects of topical application of astragalus membranaceus on allergic dermatitis.astragalus membranaceus (am) is one of the most popular health-promoting herbs in east asia, and has been used in traditional medicine for more than 2000 years. this study was performed to examine whether am suppresses atopic dermatitis (ad)-like skin lesions in balb/c mice. seven-week-old female balb/c mice were sensitized with 1-chloro-2,4-dinitrobenzene (dncb) to induce allergic dermatitis. skin sections were stained with hematoxylin and eosin (h&e) to assess epidermal and dermal hyperplasia, ...201323083228
astragalus polysaccharide stimulates glucose uptake in l6 myotubes through ampk activation and as160/tbc1d4 phosphorylation.to establish the mechanism responsible for the stimulation of glucose uptake by astragalus polysaccharide (aps), extracted from astragalus membranaceus bunge, in l6 myotubes in vitro.201323103623
effects of astragalus membranaceus with supplemental calcium on bone mineral density and bone metabolism in calcium-deficient ovariectomized rats.it has been reported that astragalus membranaceus, an asian traditional herb, has an estrogenic effect in vitro. to examine the possible role of a. membranaceus extract with supplemental calcium (ca) on bone status in calcium-deficient (lca) ovariectomized (ovx) rats, a total of 48 female rats were divided into six groups: (1) normal control, (2) sham operation with lca (sham-lca), (3) ovx with lca (ovx-lca), (4) a. membranaceus supplementation with ovx-lca (ovx-mlca), (5) ca supplementation wit ...201323136088
herbal medicines for viral myocarditis.herbal medicines are being used as a treatment for viral diseases such as viral myocarditis and numerous clinical trials have been conducted to investigate their efficacy. despite this wealth of evidence, the role of herbal medicines in the treatment of viral myocarditis is yet to be established. this is an update of the review published in 2010.201223152220
xiang-qi-tang and its active components exhibit anti-inflammatory and anticoagulant properties by inhibiting mapk and nf-κb signaling pathways in lps-treated rat cardiac microvascular endothelial cells.xiang-qi-tang (xqt) is a chinese herbal formula containing cyperus rotundus, astragalus membranaceus and andrographis paniculata. alpha-cyperone (cyp), astragaloside iv (as-iv) and andrographolide (and) are the three major active components in this formula. xqt may modulate the inflammatory or coagulant responses. we therefore assessed the effects of xqt on lipopolysaccharide (lps)-induced inflammatory model of rat cardiac microvascular endothelial cells (rcmecs). xqt, cyp, as-iv and and inhibit ...201323171279
cd4+cd25+foxp3+ t cells contribute to the antiasthmatic effects of astragalus membranaceus extract in a rat model of asthma.astragalus membranaceus (am), a traditional chinese medicinal herb, has been widely used for centuries to treat asthma in china. previous studies demonstrated that am had inhibitory effects on airway hyperresponsiveness, inflammation and airway remodeling in murine models of asthma. however, it remained unclear whether the beneficial effects of am on asthma were associated with cd4(+)cd25(+)foxp3(+) treg cells; this issue is the focus of the present work. an asthma model was established in sprag ...201323186751
effect of sanqi oral liquid on the expressions of cd4⁺, cd8⁺ and cd68⁺ cells in 5/6 nephrectomized rats with chronic renal failure.to explore the mechanisms of chinese herbal medicine sanqi oral liquid, composed of astragalus membranaceus and panpax notoginseng, in alleviating renal injury by observing its effect on the expressions of cd4(+), cd8(+) and cd68(+) cells in 5/6 nephrectomized rats with chronic renal failure.201323212567
inhibitory effect of astragalus membranaceus root on matrix metalloproteinase-1 collagenase expression and procollagen destruction in ultraviolet b-irradiated human dermal fibroblasts by suppressing nuclear factor kappa-b activity.the root of astragalus membranaceus, regarded as a tonic in traditional korean medicine, has been prescribed for long periods to treat chronic illness by boosting the immune system. ultraviolet (uv) irradiation causes damage to skin connective tissue by degrading collagen, which is a major structural component of the extracellular matrix. such damage is considered to be a cause of the wrinkling observed in premature ageing of the skin. this study has investigated the photo-protective effect of a ...201323215697
the experimental study of astragalus membranaceus on meridian tropsim: the distribution study of astragaloside iv in rat tissues.according to traditional chinese medicine (tcm) theories, tcm with different meridian tropism have different therapeutic effects. in view of the meridian tropism of astragalus membranaceus (huangqi), astragaloside iv, one of the effective phytochemicals of huangqi, was appointed and observed its distribution in rat tissues following a single intravenous (i.v.) dose. a simple and accurate lc-esi-ms/ms method was developed and validated for astragaloside iv quantification in heart, liver, spleen, ...201223217309
effects of astragalus membranaceus root processed to different particle sizes on growth performance, antioxidant status, and serum metabolites of broiler chickens.the objectives of this study were to assess the effects of supplementation of astragalus membranaceus root powder (amp) and amp processed to different particle sizes on growth performance, antioxidant status, and serum metabolites of broiler chickens. the experiment was conducted with one hundred twenty 1-d-old arbor acres broilers in 5 groups of 4 cages and for both starter (0 to 21 d) and grower (22 to 42 d) phases. the treatments were basal diet only (control) and basal diet supplemented with ...201323243245
astragalus extract attenuates allergic airway inflammation and inhibits nuclear factor κb expression in asthmatic mice.background:: astragalus membranaceus from traditional chinese herbal medicines previously showed that it possesses a strong anti-inflammatory activity. the purpose of this study was to elucidate the effect of astragalus on allergen-induced airway inflammation and airway hyperresponsiveness and investigate its possible molecular mechanisms. methods:: female balb/c mice sensitized and challenged with ovalbumin (ova) developed airway inflammation. bronchoalveolar lavage fluid was assessed for total ...201223267235
[effect of astragalus membranaceus var. mongholicus seed extracts on seed germination and seedling growth of different codonopsis pilosula caltiver].to reveal the allelopathy effect of astragalus membranaceus var. mongholicus seeds and provide information for the intercrop production.201223373205
[separation and purification of total flavonids of astragalus membranaceus with ethanol/phosphate aqueous two-phase system].to study separation and purification of flavonids with ethanol/phosphate aqueous two-phase system.201223373209
astragaloside content in the periderm, cortex, and xylem of astragalus membranaceus root.astragalosides are among the most predominant of the bioactive compounds in the root of astragalus membranaceus and are differentially concentrated depending on the anatomical part of the root in question. the aim of this study was to analyse astragaloside contents in the periderm, cortex, and xylem of a. membranaceus root, and to compare the contents between peeled and unpeeled roots. total astragalosides in the periderm were about 8-fold more concentrated than in the cortex, and 28-fold more c ...201323381847
[isoflavonoids from roots of astragalus membranaceus var. mongholicus].to study the isoflavonoid constituents of the roots of astragalus membranaceus var. mongholicus.201223397722
astragaloside iv ameliorates renal injury in streptozotocin-induced diabetic rats through inhibiting nf-κb-mediated inflammatory genes expression.accumulating evidence suggests that inflammatory processes are involved in the development of diabetic nephropathy (dn). however, there are no effective interventions for inflammation in the diabetic kidneys. here, we tested the hypothesis that astragaloside iv(as-iv), a novel saponin purified from astragalus membranaceus (fisch) bge, ameliorates dn in streptozotocin (stz)-induced diabetic rats through anti-inflammatory mechanisms. diabetes was induced with stz (65 mg/kg) by intraperitoneal inje ...201323434274
the role of traditional chinese medicines in osteogenesis and angiogenesis.the article aims to review various traditional chinese medicines (tcms) with both osteogenic and angiogenic effects, alone and in combination, and to consider whether these tcms promote osteogenesis via angiogenesis and vascular endothelial growth factor (vegf). each of the tcms involving in osteogenesis was searched through pubmed and cbmdisc using its latin name and english name, and keywords such as 'osteogenesis', 'bone', 'osteoblast', 'angiogenesis', 'vegf' were used. a total of 241 article ...201423494901
anti-inflammatory and immunoregulatory effects of yupingfeng powder on chronic bronchitis rats.to investigate the anti-inflammatory and immunoregulatory effects of yupingfeng (, ypf) powder and its components in rats.201323504545
rapid separation, identification and analysis of astragalus membranaceus fisch using liquid chromatography-tandem mass spectrometry.a rapid, sensitive and selective liquid chromatography-tandem mass spectrometry (hplc-ms-ms) method has been developed for the rapid separation and structural identification of constituents in astragali radix (ar) the analysis was conducted on an acquity hplc chromatographic instrument and a mass spectrometer using positive electrospray ionization. using a fast hplc system with an acquity hplc beh c18 column, the total analysis time for this complex herb was less than 30 min. the method used a c ...201423519564
astragaloside ii triggers t cell activation through regulation of cd45 protein tyrosine phosphatase activity.to investigate the immunomodulating activity of astragalosides, the active compounds from a traditional tonic herb astragalus membranaceus bge, and to explore the molecular mechanisms underlying the actions, focusing on cd45 protein tyrosine phosphatase (cd45 ptpase), which plays a critical role in t lymphocyte activation.201323524573
anti-inflammatory cycloartane-type saponins of astragalus membranaceus.a new cycloartane-type triterpene glycoside, agroastragaloside v (1) was isolated from the roots of astragalus membranaceus. the structure was identified as 3-o-β-(2'-o-acetyl)-d-xylopyranosyl-6-o-β-d-glucopyranosyl-(24s)-3β,6α,24α,25-tetrahydroxy- 9,19-cyclolanostane, by means of spectroscopic methods, including hr-fab/ms, 1d nmr (1h, 13c, dept), 2d nmr (gcosy, ghsqc, ghmbc, noesy), and ir spectroscopy. four known cycloartane glycosides, namely, agroastragaloside i (2), agroastragaloside ii (3) ...201323529032
effects of astragaloside iv on action potentials and ionic currents in guinea-pig ventricular myocytes.astragaloside iv (as-iv) is one of the main active constituents of astragalus membranaceus, which has various actions on the cardiovascular system. however, its electrophysiological mechanisms are not clear. in the present study, we investigated the effects of as-iv on action potentials and membrane currents using the whole-cell patch clamp technique in isolated guinea-pig ventricular myocytes. as-iv prolonged the action potential duration (apd) at all three tested concentrations. the peak effec ...201323546288
rt-qpcr analysis of dexb and gale gene expression of streptococcus alactolyticus in astragalus membranaceus fermentation.streptococcus alactolyticus strain fgm, isolated from chicken cecum, was used to increase the extract yield of polysaccharides during astragalus membranaceus fermentation. it was previously demonstrated that polysaccharides from fermented a. membranaceus by s. alactolyticus had some similar properties to those from a. membranaceus in terms of its ability to help heal hepatic fibrosis in rats and modulate immunopotentiation of broiler chicken. however, methods to increase the yield of the polysac ...201323563988
anti-inflammatory activities of an active fraction isolated from the root of astragalus membranaceus in raw 264.7 macrophages.the root of astragalus membranaceus (ar), which has been widely used in traditional chinese herbal formulae for treating foot ulcer, was found to exhibit anti-inflammatory property, but its molecular mechanism still remains unknown. we previously identified the anti-inflammatory sub-fraction using bioassay-guided fractionation. the objective of the present study was to investigate the anti-inflammatory mechanism of the major active fraction (maf) (0.039 to 0.156 mg/ml) using lipopolysaccharide ( ...201423640962
synergistic promotion of blood vessel regeneration by astragaloside iv and ferulic acid from electrospun fibrous mats.the promotion of blood vessel initiation and growth plays an important role in the realization of therapeutic vascularization and regeneration of functional tissues. astragalus membranaceus and angelica sinensis are commonly used traditional chinese medicines for enriching the blood. in the current study astragaloside iv (at, the main active ingredient of astragalus) and ferulic acid (fa, the main ingredient of angelica) were loaded into electrospun fibrous scaffolds to provide abundant and sust ...201323651405
structural features of a polysaccharide from astragalus membranaceus (fisch.) bge. var. mongholicus (bge.) hsiao.a polysaccharide astragalus polysaccharide (aps) was obtained from the boiling water extract of astragalus membranaceus (fisch.) bge. var. mongholicus (bge.) hsiao. the results of gas chromatography (gc) indicated that aps consisted of l-rhamnose (l-rha), d-xylose (d-xyl), d-glucose (d-glc), and d-galactose (d-gal) in the molar ratio of 1:4:5:1.5. its molecular weight was determined to be 3.01 × 10(5) by high-performance gel filtration chromatography. the results of (1)h nmr and (13)c nmr spectr ...201323659640
astragaloside iv attenuates glycated albumin-induced epithelial-to-mesenchymal transition by inhibiting oxidative stress in renal proximal tubular cells.in diabetic kidney disease (dkd), epithelial-to-mesenchymal transition (emt) is a classic pathological process in tubular damage. oxidative stress is considered to play an important role in dkd. astragaloside iv (a-iv), one of the main active ingredients of astragalus membranaceus, exhibits a wide range of biological activities. however, the effect of a-iv on regulating emt in tubular cells is unclear. this study aims to determine whether a-iv could attenuate glycated albumin (ga)-induced emt in ...201423719694
astragaloside iv reduces cerebral edema post-ischemia/reperfusion correlating the suppression of mmp-9 and aqp4.cerebral edema is a critical complication after intravascular thrombolysis post-acute stroke. however, clinical options remained limited for treating cerebral edema after cerebral ischemia/reperfusion (i/r) injury. in the present study, astragaloside iv, a purified extract from astragalus membranaceus, was used in the focal i/r rat model, aimed to investigate its effect on the cerebral edema. we found that astragaloside iv (10 and 20mg/kg) significantly attenuated the cerebral water content (p<0 ...201323747593
effect of formononetin on mechanical properties and chemical composition of bones in rats with ovariectomy-induced osteoporosis.formononetin is a naturally occurring isoflavone, which can be found in low concentrations in many dietary products, but the greatest sources of this substance are astragalus membranaceus, trifolium pratense, glycyrrhiza glabra, and pueraria lobata, which all belong to fabaceae family. due to its structural similarity to 17 β -estradiol, it can mimic estradiol's effect and therefore is considered as a "phytoestrogen." the aim of this study was to examine the effect of formononetin on mechanical ...201323762138
flavonoids from astragalus membranaceus and their inhibitory effects on lps-stimulated pro-inflammatory cytokine production in bone marrow-derived dendritic cells.radix astragali (astragalus membranaceus) is an important traditional chinese medicine that is widely used as a tonic to enhance the body's natural defense mechanisms. in this phytochemical study, 12 flavonoids, isoliquiritigenin (1), liquiritigenin (2), calycosin (3), calycosin 7-o-β-d-glucoside (4), formononetin (5), formononetin 7-o-β-d-glucoside (6), daidzein (7), daidzein 7-o-β-d-glucoside (8), methylnissolin (9), methylnissolin 3-o-β-d-glucoside (10), isomucronulatol (11), and isomucronula ...201423771500
a stable fixed-dose combination tablet of pseudoephedrine and kob extracts for the extended release.allergic rhinitis (ar) is characterized by inflammation of the nasal mucosa with hypersensitivity resulting from seasonal or perennial responses to specific environmental allergens and by symptoms like nasal rubbing, sneezing, rhinorrhea, lacrimation, nasal congestion and obstruction, and less frequently cough. kob extracts, which is a polyherbal medicine consisting of 5 different herbs (atractylodes macrocephala, astragalus membranaceus, saposhnikovia divaricata, ostericum koreanum and scutella ...201323780499
nf-κb inhibitory activity of sucrose fatty acid esters and related constituents from astragalus membranaceus.twelve compounds, including six sucrose fatty acid esters (1-6), four galactosyl acylglycerols (7-10), and two sphingolipids (11 and 12), were isolated from the roots of astragalus membranaceus . their structures were identified on the basis of spectroscopic analysis. among the isolated sucrose fatty acid esters, 6'-o-linoleyl sucrose (1) was identified as a new compound, and 6'-o-palmitoyl sucrose (2) and 6-o-palmitoyl sucrose (3) were isolated from nature for the first time. this is the first ...201323815760
astragalus polysaccharide improves muscle atrophy from dexamethasone- and peroxide-induced injury in vitro.astragalus polysaccharide (aps) is an important bioactive component of astragalus membranaceus bunge (leguminosae) that has been used in traditional chinese medicine for treating muscle wasting, a serious complication with complex mechanism manifested as myofibers atrophy and satellite cells apoptosis. in this study, the anti-atrophy and anti-apoptotic activity of astragalus polysaccharide (aps) was characterized in c2c12 skeletal muscle myotubes and myoblasts. aps inhibited dexamethasone-induce ...201323817095
a new herbal formula, ksg-002, suppresses breast cancer growth and metastasis by targeting nf- κ b-dependent tnf α production in macrophages.tumor-associated macrophages (tams) in tumor microenvironment regulate cancer progression and metastases. in breast cancer, macrophage infiltration is correlated with a poor prognosis. while metastatic breast cancer is poor prognostic with a severe mortality, therapeutic options are still limited. in this study, we demonstrate that ksg-002, a new herbal composition of radices astragalus membranaceus and angelica gigas, suppresses breast cancer via inhibiting tam recruitment. ksg-002, an extract ...201323818931
bibliometric and content analysis of the cochrane complementary medicine field specialized register of controlled trials.the identification of eligible controlled trials for systematic reviews of complementary and alternative medicine (cam) interventions can be difficult. to increase access to these difficult to locate trials, the cochrane collaboration complementary medicine field (cam field) has established a specialized register of citations of cam controlled trials. the objective of this study is to describe the sources and characteristics of citations included in the cam field specialized register.201323826877
first report of fingerprinting dried herbal products using a subtractive diversity array.introduction sequence - independent microarrays have never been used to identify and authenticate dried herbal plants.201323828332
extracts from astragalus membranaceus limit myocardial cell death and improve cardiac function in a rat model of myocardial ischemia.the root of astragalus membranaceus, known as "huang-qi", is one of the most widely used chinese herbal medicines for the prevention and treatment of myocardial ischemic diseases. however, the mechanisms governing its therapeutic effects are largely unknown.201323968862
effects of chinese herbal recipes on immunity in immunosuppressive mice.the chinese herbal formula consisting of astragalus membranaceus, epimedium brevicornum, paeoniae alba radix and radix ophiopogonis in proper proportions were adopted in order to investigate the immunoenhancing properties of the herbal formula. fifty icr mice were randomly divided into 5 groups (ns- ns+hy-l+hy-m+hy-h+hy ). the mice in hydrocortisone (hy) groups were injected with hydrocortisone i.p. to induce the immunosuppressive condition. the mice in group ns were administered with normal sal ...201223983391
herbal medicines for viral myocarditis.herbal medicines are used as treatment for viral diseases such as viral myocarditis, and numerous clinical trials have been conducted to investigate their efficacy. despite this wealth of evidence, the role of herbal medicines in the treatment of viral myocarditis has yet to be established. this is an update of a review published in 2012.201323986406
a standardized extract from paeonia lactiflora and astragalus membranaceus induces apoptosis and inhibits the proliferation, migration and invasion of human hepatoma cell lines.paeonia lactiflora and astragalus membranaceus are two traditional chinese medicines, which are commonly used in chinese herb prescription to treat liver diseases. the protective effects of the extract prepared from the roots of paeonia lactiflora and astragalus membranaceus (pae) on liver fibrosis have been demonstrated in previous studies. however, its effect on hepatocellular carcinoma (hcc) has not been investigated to date. in this study, the effects of pae on the apoptosis, proliferation, ...201324002667
identification of multiple ingredients for a traditional chinese medicine preparation (bu-yang-huan-wu-tang) by liquid chromatography coupled with tandem mass spectrometry.bu-yang-huan-wu-tang (byhwt) is a popular traditional chinese medicine formula consisting of seven herbal medicines (astragalus membranaceus, angelica sinensis, paeonia lactiflora, ligusticum chuanxiong, carthamus tinctorius, amygdalus persica and pheretima aspergillum), that has been used in china for centuries to overcome stroke-induced disability. to ensure the consistency of quality, a reliable analytical method is required, therefore, we developed a liquid chromatography with tandem mass sp ...201324036516
antitumor and immunomodulatory activity of astragalus membranaceus polysaccharides in h22 tumor-bearing mice.in the present study, we investigated the antitumor and immunomodulatory activity of astragalus membranaceus polysaccharide (amp) on liver cancer using murine h22 hepatocarcinoma model. the results showed that amp (100 and 400 mg/kg) could effectively inhibit the solid tumor growth of h22 hepatocarcinoma transplanted in balb/c mice. besides, the body weight, spleen/thymus indexes and phagocytotic function of macrophage of h22 tumor bearing mice were also improved in two amp treated groups. furth ...201324060282
[optimized treatment program for unstable angina by integrative medicine based on partially observable markov decision process].to initially optimize comprehensive treatment program for treating and preventing unstable angina (ua) by integrative medicine (im).201324063205
assessment of peeling of astragalus roots using 1h nmr- and uplc-ms-based metabolite profiling.a metabolomic analysis was performed to examine the postharvest processing of astragalus membranaceus roots with a focus on the peeling procedure using (1)h nmr and uplc-ms analyses. principal component analysis (pca) score plots from the (1)h nmr and uplc-ms data showed clear separation between peeled and unpeeled astragalus roots. peeled roots exhibited significant losses of several primary metabolites, including acetate, alanine, arginine, caprate, fumarate, glutamate, histidine, n-acetylaspa ...201324073592
pharmacokinetics and hepatic uptake of gliquidone affected by huangqi injection.the root of astragalus membranaceus also known as huang qi in china is a common traditional chinese herb with extensive pharmacological activities. huangqi injection (hi), a common preparation of huang qi, was wildly co-administered with gliquidone to treat diabetes mellitus and diabetic nephropathy in clinic of china. the aim of the study was to investigate the effect of hi on the pharmacokinetics and hepatic uptake of gliquidone and related mechanism to ensure the safety and efficacy of their ...201424085486
microscopic research on a multi-source traditional chinese medicine, astragali radix.astragali radix is a widely and commonly used chinese herbal medicine, which is derived from roots of astragalus membranaceus var. mongholicus and astragalus membranaceus. to find a quick and reliable method of distinguishing these two species of astragali radix and of determining the age of a sample, microscopic characteristics of the two species were compared using light microscopy. the results showed that the microscopic characteristics, such as number of layers of phellem, continuing lignifi ...201424085529
astragaloside iv stimulates angiogenesis and increases nitric oxide accumulation via jak2/stat3 and erk1/2 pathway.astragaloside iv (as-iv), one of the major active constituents of astragalus membranaceus in traditional chinese medicine, has been widely used to treat ischemic diseases. however, the potential mechanism is this action is unclear. in this study, we tested the hypothesis that as-iv might promote angiogenesis through multiple signaling pathways. our data indicate that as-iv treatment promotes umbilical vein endothelial cells (huvec) proliferation, migration, and tube formation. as-iv treatment al ...201324135938
astragalus saponins affect proliferation, invasion and apoptosis of gastric cancer bgc-823 cells.astragalus memebranaceus is a traditional chinese herbal medicine used in treatment of common cold, diarrhea, fatigue, anorexia and cardiac diseases. recently, there are growing evidences that astragalus extract may be a potential anti-tumorigenic agent. some research showed that the total saponins obtained from astragalus membranaceus possess significant antitumorigenic activity. gastric cancer is one of the most frequent cancers in the world, almost two-thirds of gastric cancer cases and death ...201324152941
metabolic signatures of kidney yang deficiency syndrome and protective effects of two herbal extracts in rats using gc/tof ms.kidney yang deficiency syndrome (kds-yang), a typical condition in chinese medicine, shares similar clinical signs of the glucocorticoid withdrawal syndrome. to date, the underlying mechanism of kds-yang has been remained unclear, especially at the metabolic level. in this study, we report a metabolomic profiling study on a classical model of kds-yang in rats induced by hydrocortisone injection to characterize the metabolic transformation using gas chromatography/time-of-flight mass spectrometry ...201324159348
effect of ht042, herbal formula, on longitudinal bone growth in spontaneous dwarf rats.ht042 is a new herbal prescription consisting of astragalus membranaceus, phlomis umbrosa and eleutherococcus senticosus, which are used in korean medicine to stimulate growth in children. we investigated the effects of ht042 on the body weight, longitudinal bone growth, and bone length in spontaneous dwarf rats (sdr). male and female sdrs were divided into three groups: the control group (dw, 10 ml/kg/day), the recombinant human gh group (rhgh; 500 µg/kg/day), and the ht042 (100 mg/kg/day) grou ...201324169467
compound astragalus and salvia miltiorrhiza extract suppresses hepatocellular carcinoma progression by inhibiting fibrosis and pai-1 mrna transcription.astragalus membranaceus and salvia miltiorrhiza have been used for centuries in china to treat liver diseases. previous studies have shown that these herbs and their extracts inhibit the development of liver fibrosis and the proliferation and invasion of human hepatoma hepg2 cells. further study of their pharmacological effects on hepatocellular carcinoma (hcc) is needed. to investigate the effects of compound astragalus and salvia miltiorrhiza extract (case) on diethylinitrosamine (den)-induced ...201424247078
in vitro and in vivo anti-cancer activity of formononetin on human cervical cancer cell line hela.worldwide, cervical cancer (cc) is the third most common malignancy in women, and it remains a leading cause of cancer-related death of women. genomic studies indicate that phosphoinositide 3-kinase (pi3k)/akt signaling is one of the most frequently deregulated pathways in several human cancers, including cc. this signaling pathway has an important role in cancer cell proliferation, survival, motility, and metabolism, and therefore could be an attractive therapeutic target. in a previous study, ...201424272199
chemical composition and synergistic antioxidant activities of essential oils from atractylodes macrocephala and astragalus membranaceus.chemical composition of the essential oils derived from atractylodes macrocephala (ama), astragalus membranaceus (ame) and ama-ame herb pair was investigated using gas chromatography-mass spectrometry (gc-ms). antioxidant activities were evaluated by 1,1-diphenyl-2-picyrlhydrazyl (dpph) radical-scavenging and trolox equivalent antioxidant capacity (teac) assays. forty-five, ten and forty-three components were identified in ama, ame and ama-ame essential oils, respectively. ama-ame essential oil ...201324273876
a refined-jinqi-jiangtang tablet ameliorates prediabetes by reducing insulin resistance and improving beta cell function in mice.refined-jq (jq-r) is a mixture of refined extracts from three major herbal components of jinqi-jiangtang tablet: coptis chinensis (ranunculaceae), astragalus membranaceus (leguminosae), and lonicera japonica (caprifoliaceae). our previous studies have indicated that jq-r could decrease fasting blood glucose levels in diabetic mice and insulin resistance mice. investigating the hypoglycemic effect of jq-r on prediabetes has practical application value for preventing or delaying insulin resistance ...201424286962
structural features and biological activities of the polysaccharides from astragalus membranaceus.recently, a great deal of interest has been developed to isolate and investigate novel bioactive components with health benefit effects from natural resources. the dried root of astragalus membranaceus, one of the most popular health-promoting herbal medicines, has been used historically as an immunomodulating agent for the treatment of common cold, diarrhea, fatigue and anorexia for more than 2000 years. modern phytochemistry and pharmacological experiments have proved that polysaccharide is on ...201424325861
compound astragalus and salvia miltiorrhiza extracts suppress hepatocarcinogenesis by modulating transforming growth factor-β/smad signaling.previous studies showed compound astragalus and salvia miltiorrhiza extract (case), extract from astragalus membranaceus and salvia miltiorhiza, significantly suppresses hepatocellular carcinoma (hcc) in rats induced by diethylinitrosamine (den), and in vitro experiments further demonstrated that case's anti-hepg2 cell invasion is associated with transforming growth factor-β (tgf-β). we hypothesized that case's suppression of hcc is modulated by tgf-β/smad signaling, and we conducted this in viv ...201424329763
effect of the combinatory mixture of rubus coreanus miquel and astragalus membranaceus bunge extracts on ovariectomy-induced osteoporosis in mice and anti-rank signaling effect.postmenopausal osteoporosis is one of the most common disorders in women after menopause, which is linked to an estrogen deficiency and characterized by an excessive loss of trabecular bone. rubus coreanus and astragalus membranaceus have been used for their various pharmacological properties in asia as a traditional medicine. the present study evaluated the anti-osteoporotic effects of the optimal combination of rubus coreanus and astragalus membranaceus in 7:3 mixture (ram) in ovariectomized ( ...201424333364
folfox 4 combined with herbal medicine for advanced colorectal cancer: a systematic review.this systematic review evaluates the clinical evidence for the addition of herbal medicines (hms) to folfox 4 for advanced colorectal cancer (acrc) in terms of tumor response rate (trr), survival, quality of life and reduction in adverse events (aes). seven electronic databases were searched for randomized controlled trials (rcts) of folfox4 combined with hms compared to folfox4 alone. outcome data for 13 randomized controlled trials were analysed using review manager 5.1. risk of bias for objec ...201424343974
recent advances in astragalus membranaceus anti-diabetic research: pharmacological effects of its phytochemical constituents.the disease burden of diabetes mellitus is increasing throughout the world. the need for more potent drugs to complement the present anti-diabetic drugs has become an imperative. astragalus membranaceus, a key component of most chinese herbal anti-diabetic formulas, has been an important prospect for lead anti-diabetic compounds. it has been progressively studied for its anti-diabetic properties. ethnopharmacological studies have established its potential to alleviate diabetes mellitus. recent s ...201324348714
the clinical value of huangqi injection in the treatment of leucopenia: a meta-analysis of clinical controlled trials.huangqi injection is derived from astragalus membranaceus root. in china, recent reports of huangqi injection for the treatment of leucopenia have emerged. however, a systematic review of these reports has not been performed. thus, we conducted a meta-analysis of clinical controlled trials to assess the clinical value of huangqi injection in the treatment of leucopenia.201324349444
astragaloside iv inhibits doxorubicin-induced cardiomyocyte apoptosis mediated by mitochondrial apoptotic pathway via activating the pi3k/akt pathway.doxorubicin (dox) is a widely used antitumor drug whose application is seriously limited by its cardiotoxicity. mitochondria-mediated cardiomyocyte apoptosis plays a critical role in dox-induced cardiotoxicity (dic). the aim of the present study was to investigate the protective effect of astragaloside iv (3-o-beta-d-xylopyranosyl-6-o-beta-d-glucopyranosyl-cycloastragenol, as-iv), a pure saponin isolated from astragalus membranaceus, against dox-induced cardiomyocyte apoptosis in primary culture ...201424390491
astragaloside iv attenuates inflammatory cytokines by inhibiting tlr4/nf-кb signaling pathway in isoproterenol-induced myocardial hypertrophy.astragaloside iv (as iv) is one of the main effective components isolated from the traditional chinese medical herb astragalus membranaceus. the protective effect of astragalus membranaceus on myocardial hypertrophy has been extensively proved. to test the hypothesis that astragaloside iv can ameliorate the myocardial hypertrophy and inflammatory effect induced by β-adrenergic hyperactivity, we carried out in vivo and in vitro experiments.201324432369
[treatment of severe active systemic lupus erythematosus by pmc therapy combined langchuang fuzheng jiedu capsule: a clinical observation].to evaluate the efficacy and safety of pmc therapy (prednisone, methotrexate, chloroquine) combined langchuang fuzheng jiedu capsule (lfjc), thus choosing a better therapy of integrative medicine for sle in the period of glucocorticoid use.201324432670
pharmacokinetic interaction of astragaloside iv with atractylenolide i and prim-o-glucosylcimifugin in male sprague dawley rats.astragaloside iv, atractylenolide i, and prim-o-glucosylcimifugin are main medicinal components of the traditional chinese medicine prescription yu-ping-feng which is composed of three herbs: astragalus membranaceus, atractylodes macrocephala, and saposhnikovia divaricata. this study is aimed to assess the influence of atractylenolide i and prim-o-glucosylcimifugin on the pharmacokinetic profile of astragaloside iv so as to investigate the pharmacokinetic mechanisms of the yu-ping-feng prescript ...201424452462
astragaloside iv possesses antiarthritic effect by preventing interleukin 1β-induced joint inflammation and cartilage damage.the saponin astragaloside iv (ast) is one of major active components purified from astragalus membranaceus (fisch) bge, which has been used in traditional chinese medicine to treat immune disorders including rheumatoid arthritis (ra). the effects of ast on the suppression of experimental arthritis and its possible mechanisms are unknown. we measured the paw swelling of ankle joints, splenocyte proliferation, interleukin 1β (il-1β), tumor necrosis factor α (tnfα) and nitric oxide (no) formation b ...201424469603
astragaloside iv attenuates inflammatory cytokines by inhibiting tlr4/nf-кb signaling pathway in isoproterenol-induced myocardial hypertrophy.astragaloside iv(as iv) is one of the main effective components isolated from the traditional chinese medical herb astragalus membranaceus. the protective effect of astragalus membranaceus on myocardial hypertrophy has been extensively proved. to test the hypothesis that astragaloside iv can ameliorate the myocardial hypertrophy and inflammatory effect induced by β-adrenergic hyperactivity, we carried out in vivo and in vitro experiments.201324513635
nonsteroidal anti-inflammatory drug activated gene-1 (nag-1) modulators from natural products as anti-cancer agents.natural products are rich sources of gene modulators that may be useful in prevention and treatment of cancer. recently, nonsteroidal anti-inflammatory drug (nsaid) activated gene-1 (nag-1) has been focused as a target of action against diverse cancers like colorectal, pancreatic, prostate, and breast. a variety of natural agents have been reported to play a pivotal role in regulation of nag-1 through multiple transcriptional mechanisms. the aim of this paper is to review the nag-1 modulators de ...201424530873
qu feng xuan bi formula attenuates anaphylactic rhinitis-asthma symptoms via reducing eos count and regulating t cell function in rat ara models.aqueous extract of qu feng xuan bi formula (qfxbf, a chinese herb formula) which composed of radix glycyrrhizae, radix glycyrrhizae preparata, paeonia sterniana fletcher in journ, pheretima, allium macrostemon bunge, astragalus membranaceus (fisch) bunge and divaricate saposhnikovia root has been used in treatment of allergic rhinitis and asthma (ara) as an approved hospital prescription for many years in jiangsu province hospital of traditional chinese medicine, china. the present study was des ...201424548751
the in vivo and in vitro study of polysaccharides from a two-herb formula on ulcerative colitis and potential mechanism of action.lycium barbarum and astragalus membranaceus are two traditional medicinal herbs widely used in china for nourishing yin and reinforcing qi. the purpose of the study was to investigate the prophylactic and curative effects of crude polysaccharides (qhps) extracted from a two-herb formula composed of lycium barbarum and astragalus membranaceus at a ratio of 2:3 in colitis rats, and to further elucidate the potential mechanism of action in epithelial cell proliferation in vitro.201424548752
astragalus membranaceus improves exercise performance and ameliorates exercise-induced fatigue in trained mice.astragalus membranaceus (am) is a popular "qi-tonifying" herb with a long history of use as a traditional chinese medicine with multiple biological functions. however, evidence for the effects of am on exercise performance and physical fatigue is limited. we evaluated the potential beneficial effects of am on ergogenic and anti-fatigue functions following physiological challenge. male icr strain mice were randomly assigned to four groups (n = 10 per group) for treatment: (1) sedentary control an ...201424595275
oral chinese herbal medicine combined with pharmacotherapy for stable copd: a systematic review of effect on bode index and six minute walk test.this systematic review evaluated the effects of chinese herbal medicine (chm) plus routine pharmacotherapy (rp) on the objective outcome measures bode index, 6-minute walk test (6mwt), and 6-minute walk distance (6mwd) in individuals with stable chronic obstructive pulmonary disease (copd). searches were conducted of six english and chinese databases (pubmed, embase, central, cinahl, cnki and cqvip) from their inceptions until 18th november 2013 for randomized controlled trials involving oral ad ...201424622390
beneficial effects of astragaloside iv for hair loss via inhibition of fas/fas l-mediated apoptotic signaling.apoptosis with premature termination of hair follicle growth induces several types of hair loss and is one of the crucial factors of hair loss. astragaloside iv, which is a major component of astragalus membranaceus, is a cycloartane triterpene saponin. although an anti-apoptotic effect of astragaloside iv has been reported, its effects against hair loss have not been investigated. to explore the underlying mechanisms of astragaloside iv on apoptotic signaling in hair follicle, the dorsal skin o ...201424676213
anti-stress effect of astragaloside iv in immobilized mice.astragaloside iv, a major component extracted from the roots of astragalus membranaceus (am), possesses anti-inflammatory, anti-oxidative, anti-fibrotic, anti-infarction and immunoregulatory effects. to clarify anti-stress effect of am, anxiolytic and anti-inflammatory effects of 80% ethanol extract of am and astragaloside iv were investigated in immobilization stress model.201424709311
functional assessment of pharmacological telomerase activators in human t cells.telomeres are structures at the ends of chromosomes that shorten during cell division and eventually signal an irreversible state of growth arrest known as cellular senescence. to delay this cellular aging, human t cells, which are critical in the immune control over infections and cancer, activate the enzyme telomerase, which binds and extends the telomeres. several different extracts from the astragalus membranaceus root have been documented to activate telomerase activity in human t cells. th ...201324709644
antihepatoma and liver protective potentials of ganoderma lucidum ( ling zhi) fermented in a medium containing black soybean ( hēi dòu) and astragalus membranaceus ( shēng huáng qí).the antihepatoma activity and liver protective function of the fermentation products (5 l fermenator) of ganoderma lucidum (gl; ling zhi) cultivated in a medium containing black soybean (bs; hēi dòu) and astragalus membranaceus (am; shēng huáng qí) at different fermentation temperatures were investigated in this study. hep 3b cells pretreated with lovastatin were used to study the antihepatoma activity, and possible active components were analyzed by reverse-phase high-performance liquid chromat ...201324716165
the effect of astragalus polysaccharide on the epstein-barr virus lytic cycle.effects of a polysacharide from chinese herbal plant astragalus membranaceus (aps) on the expression of epstein-barr virus (ebv) immediate early proteins zta, rta and ea-d in raji cells were examined. ebv switch from latent to lytic cycle in raji cells was induced by 12-o-tetradecanoylphorbol-13-acetate (tpa) and sorbol butyrate (sb) and the effects of aps were examined by immunofluorescence, western blotting and flow cytometry. aps in a non-cytotoxic concentration of 30 μg/ml significantly supp ...201424717032
a chinese 2-herb formula (nf3) promotes hindlimb ischemia-induced neovascularization and wound healing of diabetic rats.diabetic foot ulcer is closely associated with peripheral vascular disease. enhancement of tissue oxidative stress, reduction of nitric oxide (no) and angiogenic growth factors, and abnormal matrix metalloproteinase (mmp) activity are pathophysiological factors in post-ischemic neovascularization and diabetic wound healing. our previous study demonstrated that the chinese 2-herb formula, nf3, showed significant wound healing effects on diabetic foot ulcer rats. a novel rat diabetic foot ulcer wi ...201624731763
astragalus saponin attenuates the expression of fibrosis-related molecules in irradiated cardiac fibroblasts.the main pathological change of radiation-induced heart disease is fibrosis. emerging evidence has indicated that astragalus membranaceus and its extractant, astragalus saponin (ast), were used for treating fibrosis diseases. in the present study, the effects of ast on fibrosis damage induced by irradiation were determined. after being irradiated with 1 or 2-gy x-rays, obvious changes of endoplasmic reticulum morphology were observed in cardiac fibroblasts (cfs), suggesting that its protein proc ...201424739634
astragalus membranaceus as a cause of increased ca19-9 and liver and kidney cysts: a case report.astragalus membranaceus, one of the most common chinese herbs, is widely used to prevent and treat a variety of diseases. very few adverse reactions, caused by a. membranaceus, have been reported in the literature. the purpose of this article was to report a case of marked increase in carbohydrate antigen 19-9 (ca19-9) and the formation of liver and kidney cysts following oral administration of a. membranaceus.201424806627
in vitro synergistic antioxidant activity and identification of antioxidant components from astragalus membranaceus and paeonia lactiflora.many traditionally used herbs demonstrate significantly better pharmacological effects when used in combination than when used alone. however, the mechanism underlying this synergism is still poorly understood. this study aimed to investigate the synergistic antioxidant activity of astragalus membranaceus (ame) and paeonia lactiflora (pl), and identify the potential antioxidant components by 1,1-diphenyl-2-picrylhydrazine (dpph) radical spiking test followed by a high performance liquid chromato ...201424816851
a network pharmacology study of chinese medicine qishenyiqi to reveal its underlying multi-compound, multi-target, multi-pathway mode of action.chinese medicine is a complex system guided by traditional chinese medicine (tcm) theories, which has proven to be especially effective in treating chronic and complex diseases. however, the underlying modes of action (moa) are not always systematically investigated. herein, a systematic study was designed to elucidate the multi-compound, multi-target and multi-pathway moa of a chinese medicine, qishenyiqi (qsyq), on myocardial infarction. qsyq is composed of astragalus membranaceus (huangqi), s ...201424817581
high-throughput analysis and characterization of astragalus membranaceus transcriptome using 454 gs flx.astragalus membranaceus (fisch.) bge (ar), one of the most important medicinal plants in asia, was found to exhibit various bioactivities. due to limited genomic and transcriptomic data, the biosynthetic pathway of the major bioactive compound in ar, is currently unclear. in this study, 454 gs flx technology was employed to produce a substantial expressed sequence tag (est) dataset from the ar. in all, 742721 high-quality reads from the ar were produced using roche gs flx titanium. a total of 98 ...201424828103
identification of angelica oil as a suppressor for the biological properties of danggui buxue tang: a chinese herbal decoction composes of astragali radix and angelica sinensis radix.danggui buxue tang (dbt), a chinese herbal decoction commonly used in treating women׳s ailments, contains two herbs: angelica sinensis radix (asr) and astragali radix (ar). traditionally, asr had to be pre-treated with yellow wine before the herbal preparation, which reduced the amount of volatile oil in water extract of asr and dbt, and meanwhile the volatile oil-reduced dbt processed better bioactivities in cell cultures. the present study aimed to investigate the effect of volatile oil from a ...201424837305
an integrated analysis for determining the geographical origin of medicinal herbs using icp-aes/icp-ms and (1)h nmr analysis.icp-ms and (1)h nmr are commonly used to determine the geographical origin of food and crops. in this study, data from multielemental analysis performed by icp-aes/icp-ms and metabolomic data obtained from (1)h nmr were integrated to improve the reliability of determining the geographical origin of medicinal herbs. astragalus membranaceus and paeonia albiflora with different origins in korea and china were analysed by (1)h nmr and icp-aes/icp-ms, and an integrated multivariate analysis was perfo ...201424837936
selenium-dependent antitumor immunomodulating activity of polysaccharides from roots of a. membranaceus.roots of astragalus membranaceus (fish.) bge. var. mongholicus (bge.) hsiao (a. membranaceus) have been long used as an auxiliary reagent supporting cancer treatment. here, we compared the chemical composition and antitumor immunomodulating activity of polysaccharides from roots of a. membranaceus (pams) from five major habitats in inner mongolia, pr china. we revealed that compositions of monosaccharides and amino acids were comparable among pams from different habitats. however, amounts of sel ...201424857867
accumulation of flavonoids and related gene expressions in different organs of astragalus membranaceus bge.astragalus membranaceus is one of the important medicinal plant in china and korea. it is used to increase metabolism and digestion, enhance the immune system, and promote the healing of wounds and injuries. in the present study, we used quantitative real-time pcr to investigate the expression of genes related to the biosynthesis of flavonoids, in addition to high-performance liquid chromatography to assess calycosin and calycosin-7-o-β-d-glucoside accumulation, in the different plant organs of ...201424903957
protective effects of astragaloside iv against amyloid beta1-42 neurotoxicity by inhibiting the mitochondrial permeability transition pore opening.mitochondrial dysfunction caused by amyloid β-peptide (aβ) plays an important role in the pathogenesis of alzheimer disease (ad). substantial evidence has indicated that the mitochondrial permeability transition pore (mptp) opening is involved in aβ-induced neuronal death and reactive oxygen species (ros) generation. astragaloside iv (as-iv), one of the major active constituents of astragalus membranaceus, has been reported as an effective anti-oxidant for treating neurodegenerative diseases. ho ...201424905226
myelo-enhancement by astragalus membranaceus in male albino rats with chemotherapy myelo-suppression. histological and immunohistochemical study.myelosuppression is the most common toxicity encountered in the oncology clinic today. this study was planned to investigate the possible protective and therapeutic role of the traditional chinese medicinal herb; astragalus membranaceus (am), on chemotherapy-induced myelosuppression.201424921023
astragalus membranaceus up-regulate cosmc expression and reverse iga dys-glycosylation in iga nephropathy.decreased core i β3-gal-t-specific molecular chaperone (cosmc) expression induced iga1 aberrant glycosylation is the main characteristic of iga nephropathy (igan). this study tried to elucidate the effect of astragalus membranaceus on cosmc expression and iga o-glycosylation of peripheral b lymphocytes in igan patients.201424942185
astragalus polysaccharide inhibits isoprenaline-induced cardiac hypertrophy via suppressing ca²⁺-mediated calcineurin/nfatc3 and camkii signaling cascades.pathological cardiac hypertrophy induced by increased sympathetic drive can subsequently lead to congestive heart failure, which represents the major cause of morbidity and mortality worldwide. astragalus polysaccharide (aps) is an active compound extracted from chinese herb astragalus membranaceus (am), a frequently used "qi-invigorating" herbal medicine in traditional medicine broadly used for the treatment of cardiovascular and other diseases. currently, little is known about the effect of ap ...201424975447
herbal extract sh003 suppresses tumor growth and metastasis of mda-mb-231 breast cancer cells by inhibiting stat3-il-6 signaling.cancer inflammation promotes cancer progression, resulting in a high risk of cancer. here, we demonstrate that our new herbal extract, sh003, suppresses both tumor growth and metastasis of mda-mb-231 breast cancer cells via inhibiting stat3-il-6 signaling path. our new herbal formula, sh003, mixed extract from astragalus membranaceus, angelica gigas, and trichosanthes kirilowii maximowicz, suppressed mda-mb-231 tumor growth and lung metastasis in vivo and reduced the viability and metastatic abi ...201424976685
formononetin inhibits migration and invasion of mda-mb-231 and 4t1 breast cancer cells by suppressing mmp-2 and mmp-9 through pi3k/akt signaling pathways.formononetin is a naturally existing isoflavone, which can be found in the roots of astragalus membranaceus, trifolium pratense, glycyrrhiza glabra, and pueraria lobata. it was found to be associated with inhibition of cell proliferation and cell cycle progression, as well as induction of apoptosis in various cancer cell lines. however, the effect of formononetin on breast cancer cell metastasis remains unclear. in this study, we examined the effect of formononetin on the migration and invasion ...201424977660
astragaloside iv inhibits progression of lung cancer by mediating immune function of tregs and ctls by interfering with ido.tumor cells have developed multiple mechanisms to escape immune recognition mediated by t cells. indoleamine 2,3-dioxygenase (ido), a tryptophan-catabolizing enzyme inducing immune tolerance, is involved in tumor escape from host immune systems in mice. astragaloside iv (as-iv), an extract from a commonly used chinese medicinal plant astragalus membranaceus, has been shown to be capable of restoring the impaired t-cell functions in cancer patients. the purpose of this study was to investigate th ...201424980548
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