Publications

pulmonary cryptococcosis.	cryptococcosis is an invasive fungal infection (ifi), caused predominantly by cryptococcus neoformans or cryptococcus gattii, that affects both immunocompromised (ic) and non-ic patients. although the most serious disease manifestation is meningoencephalitis, cryptococcal pneumonia is underdiagnosed and may disseminate to the central nervous system (cns) and other sites depending upon host defenses and administration of appropriate antifungal therapy. the clinical presentation of pulmonary crypt ...	2011	22167400
cryptococcus gattii comparative genomics and transcriptomics: a nih/niaid white paper.	cryptococcus gattii is an emerging global pathogen. recent reports suggest that c. gattii cryptococcosis is more common in immunocompetent as well as hiv-infected aids patients than earlier estimated. an ongoing outbreak of c. gattii in vancouver, canada, and the us pacific northwest has heightened public health awareness in north america. we have few clues as to what causes emergence or re-emergence of highly pathogenic strains, why c. gattii split up from its sibling pathogen c. neoformans, wh ...	2011	22179781
Fatal Disseminated Cryptococcus gattii Infection in New Mexico.	We report a case of fatal disseminated infection with Cryptococcus gattii in a patient from New Mexico. The patient had no history of recent travel to known C. gattii-endemic areas. Multilocus sequence typing revealed that the isolate belonged to the major molecular type VGIII. Virulence studies in a mouse pulmonary model of infection demonstrated that the strain was less virulent than other C. gattii strains. This represents the first documented case of C. gattii likely acquired in New Mexico.	2011	22194869
capsules from pathogenic and non-pathogenic cryptococcus spp. manifest significant differences in structure and ability to protect against phagocytic cells.	capsule production is common among bacterial species, but relatively rare in eukaryotic microorganisms. members of the fungal cryptococcus genus are known to produce capsules, which are major determinants of virulence in the highly pathogenic species cryptococcus neoformans and cryptococcus gattii. although the lack of virulence of many species of the cryptococcus genus can be explained solely by the lack of mammalian thermotolerance, it is uncertain whether the capsules from these organisms are ...	2012	22253734
temperate climate niche for cryptococcus gattii in northern europe.	to the editor: cryptococcus gattii was considered to be geographically restricted to countries with tropical and subtropical climates until 1999, when an outbreak of cryptococcosis in humans and animals occurred in the temperate climate of vancouver island, british columbia, canada (1). montagna et al. reported the first environmental c. gattii in europe from the mediterranean region of italy; these authors isolated it from 11 (4.3%) of 255 samples of plant detritus of eucalyptus camaldulensis t ...	2012	22261398
cryptococcus gattii vgiii isolates causing infections in hiv/aids patients in southern california: identification of the local environmental source as arboreal.	ongoing cryptococcus gattii outbreaks in the western united states and canada illustrate the impact of environmental reservoirs and both clonal and recombining propagation in driving emergence and expansion of microbial pathogens. c. gattii comprises four distinct molecular types: vgi, vgii, vgiii, and vgiv, with no evidence of nuclear genetic exchange, indicating these represent distinct species. c. gattii vgii isolates are causing the pacific northwest outbreak, whereas vgiii isolates frequent ...	2014	25144534
molecular epidemiology and in vitro antifungal susceptibility testing of 108 clinical cryptococcus neoformans sensu lato and cryptococcus gattii sensu lato isolates from denmark.	cryptococcosis is mainly caused by members of the cryptococcus gattii/cryptococcus neoformans species complexes. here, we report the molecular characterisation and in vitro antifungal susceptibility of danish clinical cryptococcal isolates. species, genotype, serotype and mating type were determined by amplified fragment length polymorphism (aflp) fingerprinting and qpcr. eucast e.def 7.2 mics were determined for amphotericin b, flucytosine, fluconazole, voriconazole and isavuconazole. most isol ...	2016	27061834
mlst and whole-genome-based population analysis of cryptococcus gattii vgiii links clinical, veterinary and environmental strains, and reveals divergent serotype specific sub-populations and distant ancestors.	the emerging pathogen cryptococcus gattii causes life-threatening disease in immunocompetent and immunocompromised hosts. of the four major molecular types (vgi-vgiv), the molecular type vgiii has recently emerged as cause of disease in otherwise healthy individuals, prompting a need to investigate its population genetic structure to understand if there are potential genotype-dependent characteristics in its epidemiology, environmental niche(s), host range and clinical features of disease. multi ...	2016	27494185
current status of taxonomy of pathogenic yeasts.	fungal taxonomy has been reconstructed on the basis of genome information, and new nomenclatural rules have been enacted from 2013. it has been proposed that cryptococcus neoformans and cryptococcus gattii be reclassified into two species (c. neoformans and cryptococcus deneoformans) and five species (c. gattii, cryptococcus bacillisporus, cryptococcus deuterogattii, cryptococcus tetragattii, and cryptococcus decagattii), respectively. the genus trichosporon has been reclassified into five gener ...	2017	28855483