Publications
| Title | Abstract | Year Filter | PMID(sorted ascending) Filter |
|---|
| salmonella typhimurium arthritis in rheumatoid disease. | septic arthritis is a well recognized complication of rheumatoid arthritis (british medical journal, 1976; mitchell et al., 1976), particularly after joint replacement (freeman, 1976). we report here infection with an unusual organism--salmonella typhimurium. | 1977 | 333539 |
| an epidemic of salmonella typhimurium infection among aircraft passengers. | in february 1976 an outbreak of gastroenteritis occurred among 819 aircraft passengers to and from gran canaria. 360 of them had gastroenteritis and 88 were hospitalized. fecal specimens were collected from 710 of the passengers and 344 of them were positive for salmonella typhimurium phage type 15. food served on the flight was the source of infection. the repeated incidences of this kind support the necessity of laying down rules and recommendations for the control of air catering services. | 1977 | 333553 |
| mutagenicity studies with praziquantel, a new anthelmintic drug: tissue-, host-, and urine-mediated mutagenicity assays. | praziquantel, a new anthelmintic drug with activity against all species of schistosomes pathogenic to man, and against a wide range of cestodes, was tested for mutagenic potential. for the detection of both base substitutions and frameshift mutations, salmonella typhimurium ta 100 and ta 98 were used as tester strains. using the plate assay with and without added s-9, host-mediated assay and urine-mediated assay without and after incubation with beta-glucuronidase/arylsulfatase, no mutagenic act ... | 1977 | 334117 |
| the separation and properties of two penicillin-binding proteins from salmonella typhimurium. | 1977 | 334539 | |
| [salmonella typhimurium--test system for detecting the mutagenic activity of environmental pollutants. ii. mutagenic effect of heavy metal salts in an in vitro system with metabolic activation]. | mutagenic effect of zinc chloride on salmonella typhimurium strain was detected using in vitro metabolic activation system. cadmium chloride showed no significant mutagenic activity in the same system. it is recommended to use both in vitro and in vivo metabolic activation systems in mutagenicity testing of chemicals. | 1977 | 334635 |
| periplasmic space in salmonella typhimurium and escherichia coli. | the volume of the periplasmic space in escherichia coli and salmonella typhimurium cells was measured. this space, in cells grown and collected under conditions routinely used in work with these bacteria, was shown to comprise from 20 to 40% of the total cell volume. further studies were conducted to determine the osmotic relationships between the periplasm, the external milieu, and the cytoplasm. results showed that there is a donnan equilibrium between the periplasm and the extracellular fluid ... | 1977 | 334768 |
| sugar transport. a pleiotropic membrane mutant of salmonella typhimurium. | 1977 | 334769 | |
| enzymatic degradation of polygalacturonic acid by yersinia and klebsiella species in relation to clinical laboratory procedures. | as scored by several specified plating procedures, clinical and environmental strains of yersinia enterocolitica, yersinia pseudotuberculosis, and klebsiella pneumoniae "oxytocum" showed detectable, albeit generally weak, ability to digest polygalacturonic (pectic) acid. none of these bacterial strains had the vigorous and rapid pectolytic activity on these polygalacturonic acid-containing media that is typical of soft-rot erwinia species, although some of the oxytocum strains came fairly close. ... | 1977 | 334794 |
| virulence of salmonella typhimurium harbored in the feces of carrier-dog for mice. | 1977 | 335142 | |
| spontaneous, ultraviolet and ionizing radiation mutagenesis in two auxotrophic strains of salmonella typhimurium carrying an r plasmid. | ultraviolet-induced, gamma-induced and spontaneous mutation yields were studied in two different auxotrophic strains of salmonella typhimurium in the presence and absence of the uv-protecting drug resistance transfer factor r-utrecht. one strain, carrying the hisc527 (amber) mutation, showed significantly increased spontaneous, uv- and gamma-induced mutability in the presence of the r-utrecht plasmid. the other strain, carrying the trpd1 mutation (thought to be a missense mutation), also showed ... | 1977 | 335234 |
| mandelonitrile beta-glucuronide: synthesis and characterization. | mandelonitrile beta-glucuronide, the compound patented as laetrile, has been synthesized from rabbit liver uridine diphosphate-glucuronosyl transferase immobilized on beaded sepharose, has been analyzed by thin-layer chromatography, nuclear magnetic resonance, and gas chromatography-mass spectrometry, and has been tested for cytotoxicity and mutagenic activity with salmonella typhimurium strains ta 98 and ta 100. several commercial laetrile preparations contained no glucuronide; they contained a ... | 1977 | 335509 |
| properties of the ames salmonella mutants lodged in the gastrointestinal tract of gnotobiotic rats. | an association of the histidine auxotroph of salmonella typhimurium (strain ta1538) within the gastrointestinal tract of otherwise germ-free sprague-dawley rats is maintained during observations for up to 7 months. the bacteria exceed concentrations of 10(7)/g in the forestomach and exceed concentrations of 10(8)/g in the lower bowel and feces. when carcinogens are ingested, the number of revertants in the feces increases. the ingestion of structurally related compounds which are not mutagenic t ... | 1977 | 335870 |
| transport of [14c]gly-pro in a proline peptidase mutant of salmonella typhimurium. | the transport of [14c]gly-pro was examined using a mutant of salmonella typhimurium (strain tn87) deficient in an x-pro dipeptidase and an x-pro-y iminopeptidase. the dipeptide was taken up by one saturable transport system having a km of 5.3-10(-7)m and a v of 1.4 nmol/mg dry wt cell per min. the uptake of gly-pro was not inhibited by amino acids or tripeptides and the transport system exhibited a rather broad side chain specificity for dipeptides. dipeptides containing hydrophobic residues wer ... | 1977 | 336092 |
| complex medium toxicity to some dna repair-deficient strains of salmonella typhimurium. | the recovery of several strains of salmonella typhimurium lt-2 which had first been grown in minimal medium varies when the organisms are grown on minimal medium agar and complex medium agar. the strains tested included mutants with deficiencies in dna-repair systems (uvrb-and rec-), a deep rough (rfa-) mutant, and a double mutant carrying both the uvrb- and the rfa-mutation. the uvrb- and rec-mutations imparted sensitivity to complex medium agar. the rfa-mutation suppressed the sensitivity of t ... | 1977 | 336166 |
| inhibitory effects of selenium on 1,2-dimethylhydrazine and methylazoxymethanol colon carcinogenesis: correlative studies on selenium effects on the mutagenicity and sister chromatid exchange rates of selected carcinogens. | selenium (se) inhibition of either the activation of test compounds and/or mutagenic events elicited by activated compounds is suggested by experimental rat assays, mutagenesis assays, and assays with human lymphocytes in culture. the colon tumor incidence in 1,2-dimethylhydrazine (dmh)-treated rats was reduced from 87% to 40% by 4 ppm se supplements in the drinking water. supplemental se decreased the total number of colon tumors induced by dmh more than three-fold and by methylazoxymethanol (m ... | 1977 | 336188 |
| mutagenesis by 4-nitrobenzofurazans and furoxans. | 15 nitrobenzofurazans and 10 nitrobenzofuroxans synthesized primarily for testing as potential anti-rheumatic drugs were also tested for mutagenicity in salmonella typhimurium strains ta98 and ta100. the method used involved placing each compound in a "well" cut out of a plate of selective medium previously seeded with the appropriate tester strain, and then adding a rat liver microsome/cofactor mixture to one of the two wells on each plate. this method is considerably cheaper and more convenien ... | 1977 | 336231 |
| effect of salmonella typhimurium on myoelectrical activity in the rabbit ileum. | 1978 | 336451 | |
| liability to hydrophobic and charge interaction of smooth salmonella typhimurium 395 ms sensitized with anti-ms immunoglobulin g and complement. | sensitization of smooth salmonella typhimurium 395 ms bacteria with hyper-immune anti-ms immunoglobulin g (igg) antibodies increased the liability to hydrophobic interaction as assessed by the affinity for a column of octyl-sepharose. after sensitization, the material originally eluted with 1 m (nh4)so4 in a 0.01 m phosphate buffer (ph 6.8) was not desorbed until the ionic strength was reduced to nil, and 0.1% (vol/vol) triton x-100 in the 0.01 m phosphate buffer was used as eluant. furthermore, ... | 1977 | 336538 |
| effect of some r factors on the sensitivity of rough enterobacteriaceae to human serum. | eight plasmids out of 26 tested confer partial serum resistance to escherichia coli k-12 strains (bhs character). four bhs+ plasmids were tested in a rough salmonella typhimurium host, and three conferred partial serum resistance to this host as well. plasmids representative of 19 different incompatibility groups were examined; the bhs+ property was found in some (but not all) representatives of groups n, o, s, t, w, and f'lac (fi), and there was no apparent association between other plasmid mar ... | 1977 | 336539 |
| mouse virulence of salmonella typhimurium mutants deficient in two major outer membrane proteins. | the role of several outer membrane components as virulence factors is well established. we have now isolated spontaneous mutants and conjugational hybrids of smooth mouse virulent salmonella typhimurium deficient in two major outer-membrane proteins. the lack of the 34,000- and/or 36,000-dalton proteins was confirmed by sodium dodecyl sulfate-polyacrylamide gel electrophoresis. mutants and recombinants were then tested for their mouse virulence by intraperitoneal inoculation and were found to be ... | 1977 | 336546 |
| salmonella-associated conjunctivitis in a cat. | salmonella typhimurium-associated conjunctivitis in an adult female cat was characterized by epiphora and blepharospasm. the cat also harbored intestinal s typhimurium, as did one other cat in the same shipment of 7 cats obtained from a commercial cat dealer. the 3 isolates were resistant to ampicillin, cephaloridine, cephalothin, streptomycin, triple sulfonamides, and tetracycline. all 3 isolates were capable of transferring a part of the antibiotic resistance pattern to an escherichia coli k-1 ... | 1977 | 336590 |
| survival of salmonella eastbourne and salmonella typhimurium in milk chocolate prepared with artificially contaminated milk powder. | milk chocolate mass containing salmonellas was prepared by mixing artificially contaminated milk powder with the other ingredients at a temperature of about 40 degrees c. from this mass bars were made. two series were prepared, with s. eastbourne and s. typhimurium respectively. the number of surviving salmonellas was counted after various periods of storage, up to 19 months. s. eastbourne was reduced in numbers during 19 months from an initial count of ca. 3 x 10(4) to ca. 3 x 10(2) per 100 g o ... | 1977 | 336788 |
| effects of antibiotics on the survival of salmonella in the american cockroach. | the faecal survival of salmonella typhimurium orally administered to restrained american cockroaches maintained on an antibiotic diet was investigated. significant reductions in median numbers of total aerobic faecal microorganisms were noted in insects fed antibiotics daily, and when salmonella was introduced to this modified micro-environment, it persisted for 44 days in all specimens. multiplication of the pathogen was also observed in these insects, with numbers often exceeding 10(3) times t ... | 1977 | 336789 |
| clonal distribution of resistance plasmid-carrying salmonella typhimurium, mainly in the middle east. | strains of salmonella typhimurium of predominantly middle eastern origin, but distributed from england to india, were found to carry at least three types of resistance plasmid. the most important was initially identified as an f(i) plasmid by compatibility tests, but differs from the f factor on the one hand and the f(i) factors r162 and colv on the other. the three groups of f(i) plasmids can be distinguished by their compatibility reactions with the mp10 plasmid of s. typhimurium (smith, humph ... | 1977 | 336792 |
| a salmonella typhimurium endonuclease that converts native dna to fragments of about 8 x 10(5) daltons. | crude extracts of salmonella typhimurium were found to contain an endonuclease that degraded double-stranded linear dna from bacteria and phages to fragments with a molecular weight of about 8 x 10(5). the nuclease did not have an absolute requirement for mg2+. one discrete intermediate product had a molecular weight of 6-6 x 10(6). extracts from two different mutants were tested: one completely lacked the endonuclease activity (strain db5575), and the other showed an absolute requirement for mg ... | 1977 | 336842 |
| the utilization of pentoses and pentitols by different biotypes of salmonella typhimurium. | 1977 | 336843 | |
| genetic studies of hybrids between coliphage lambda and salmonella phage p22: genetic analysis of the p22-lambda hybrid class. | p22-lambda hybrids which retain the protein coat of p22 have been isolated and characterized into two types. type 1 hybrids which have the c through o-p genes of lambda are unable to grow lytically on salmonella typhimurium. on the other hand, type 2 hybrids which contain only the c region of lambda, plated on s. typhimurium. both hybrid types retained the generalized transducing and antigenic conversion capabilities of p22. | 1977 | 337122 |
| identification of the sid outer membrane receptor protein in salmonella typhimurium sl1027. | a protein of molecular weight 78,000 daltons, missing in albomycin and phage es18 resistant mutants, has been identified in the outer membrane of salmonella typhimurium sl1027. mutants with a tonb like resistance and over production of outer membrane proteins due to iron shortage were also isolated. the mutation which leads to the protein deficiency maps in the sid gene region, the mutation related to overproduction of proteins maps near trp. although the s. typhimurium and the e. coli protein m ... | 1977 | 337132 |
| transcription termination at the trp operon attenuators of escherichia coli and salmonella typhimurium: rna secondary structure and regulation of termination. | transcription termination at the attenuators of the trp operons of escherichia coli and salmonella typhimurium was studied in vitro using dna restriction fragments as templates. readthrough transcription beyond the terminators occurred with 5 and 30% efficiency, respectively, in e. coli and s. typhimurium. this difference is correlated with the stability of proposed secondary structures of the respective trp leader transcripts. secondary structure analyses of the two leader transcripts revealed ... | 1977 | 337297 |
| [iron overload: effect on specific and nonspecific immunity]. | acute overload with an iron salt in mice enhanced the virulence of a relatively avirulent type of salmonella typhimurium in a dose-dependent fashion. iron administration also partly abolished specific immunity. ferritin iron did not display the virulence-enhancing effect. | 1977 | 337471 |
| saccharin and other sweeteners: mutagenic properties. | saccharin preparations commonly distributed as artificial sweeteners exhibited mutagenic activity in bacterial tests. when administered orally to mice, mutagenic activity was demonstrable in the urines of these animals as well as in a host-mediated assay. highly purified saccharin was not mutagenic in the direct assay, but the urines of mice to which this material had been administered exhibited mutagenic effects on one tester strain (salmonella typhimurium ta100). two other sweeteners, neohespe ... | 1977 | 337489 |
| properties of the cell envelope and a cell-envelope protein of pseudomonas facilis. | the molecular weight of the protein moiety of a phospholipoprotein complex isolated from pseudomonas facilis has been examined with a variety of sodium dodecylsulfate-polyacrylamide gel electrophoretic systems. a molecular weight of 35 000 was determined for the protein in all analyses. a 35 000-dalton protein was present in the edta extract of p. facilis and in the cytoplasmic and outer membrane fractions, but not in the lipopolysaccharide and peptidoglycan. prior inoculation of mice with the p ... | 1977 | 337920 |
| selection of an in vitro carcinogenicity test for derivatives of the carcinogen hexamethylphosphoramide. | the demonstration that hexamethylphosphoramide (hmpa) possesses potent carcinogenic properties has raised doubts about the safety of exposure to other phosphoric amides. in order to define a suitable short-term test with which to evaluate such analogues, the response of the salmonella typhimurium mutation assay of ames and cell transformation assay of styles to hmpa and 3 selected analogues has been studied. these analogues were the related leukaemogen phosphoramide, the putative non-carcinogen, ... | 1977 | 337998 |
| a mutant of the antibiotic resistance factor r124 with altered copy number. | a mutation conferring increased antibiotic resistance on salmonella typhimurium strain 11g carrying r124 was plasmid determined; strains harbouring the mutant plasmid contained more dna as ccc plasmid than those harbouring r124. the increased copy number was manifested at all growth rates tested. | 1977 | 338336 |
| role of phagocytosis in mouse virulence of salmonella typhimurium recombinants with o antigen 6,7 or 4,12. | the quality of lipopolysaccharide has previously been shown to influence the mouse virulence of salmonella so that strains with o antigen 4,12 were more virulent than their o-9,12 sister strains. immunosuppression did not alter this o-antigen-dependent difference in virulence. i have now constructed smooth o-4,12 and o-6,7 sister hybrid strains of salmonella typhimurium. no other phenotypic differences were found between these strains; they were all "common antigen" positive. in intraperitoneal ... | 1977 | 338484 |
| nitramino acids. synthesis and biological evaluation of 1-nitroproline, 1-nitropipecolic acid, and n-nitrosarcosine. | the n-nitro derivatives of secondary alpha-amino acids, viz., 1-nitroproline (1a) (l and d), 1-nitro-dl-pipecolic acid (2a), and n-nitrosarcosine (3a), were prepared by the oxidation of the corresponding nitrosamino acids with peroxytrifluoroacetic acid. these nitramino acids (1a-3a) were not active against escherichia coli, candida albicans, pseudomonas aeruginosa, or mycobacterium smegmatis, and 1a and 2a did not show mutagenic activity in a salmonella typhimurium ta-100 system, with or withou ... | 1977 | 338899 |
| intrasanguine host-mediated assay with salmonella typhimurium. | 1977 | 339068 | |
| carcinogen activation by human liver enzymes in the ames mutagenicity test. | liver post-mitochondrial supernatants derived from 10 individuals were used as the source of metabolic activation for carcinogens in the ames quantitative mutagenicity test using salmonella typhimurium ta 100. the liver samples were obtained from brain-dead donors and autopsy cases. the ability of human enzymes to activate aromatic amines ranged from the undetectable to highly active for 2-acetylaminofluorene. none of the samples exhibited any ability to activate benzidine. a generally low activ ... | 1977 | 339071 |
| mutagenicity screening of five methyl carbamate insecticides and their nitroso derivatives using mutants of salmonella typhimurium lt2. | the mutagenic activity of five methyl carbamate insecticides-carbaryl, baygon, bux-ten, landrin and methomyl-and their nitroso derivatives were investigated using histidine auxotrophs-his ta98, his ta100, his ta1535, his ta1537 and his ta1538--of salmonella typhimurium lt2 derived by ames. the methyl carbamate insecticides did not cause a signficant increase in the number of revertant colonies in any of the strains used. in contrast, the nitroso derivatives of the carbamate insecticides greatly ... | 1977 | 339072 |
| mutagenicity of hydroxamic acids for salmonella typhimurium. | p-butoxyphenylacethydroxamic acid, benzohydroxamic acid, salicylhydroxamic acid, 2-naphthohydroxamic acid, indole-2-carbohydroxamic acid and benzoylaminoacethydroxamic acid were synthesized, and their mutagenicity for salmonella typhimurium strains ta98 and ta100 were determined. except for p-butoxyphenylacethydroxamic acid, all the hydroxamic acids were mutagenic for both strains. the mutagenicity progressed in the following order: 2-naphthohydroxamic acid greater than benzohydroxamic acid and ... | 1977 | 339075 |
| mutagenicity of fume particles from stainless steel welding. | welding fume particles collected from different welding procedures were tested for mutagenicity in escherichia coli, with the inhibition zone in pol a- as compared to pol a+, and in salmonella typhimurium, ta 100 strain. while no mutagenicity was found with mild steel welding, a mutagenic effect was established with samples from stainless steel welding. this mutagenicity was particularly associated with manual metal arc (mma) welding, and less so with metal inert-gas welding. a decrease in or an ... | 1977 | 339336 |
| [r-factor distribution and characteristics of the e. coli isolated from pigs]. | studied was the occurrence of the r-factors in escherichia coli isolated from pigs. it was demonstrated that in 73.3 per cent of the cases drug resistance could be transmitted to citrobacter. in this instance an occasional drop-out of the markers of resistance to kanamycin, neomycin, ampicillin, tetracycline, and chloramphenicol was observed. in the author's experiments no transmission of the marker of resistance to furazolidon was established. the transmission of the signs of resistance to kana ... | 1977 | 339513 |
| silver sulfadiazine: lack of mutagenic activity. | silver sulfadiazine was found to be devoid of mutagenic potential in a sensitive mutagenicity assay using salmonella typhimurium. in view of the close relationship between mutagenicity in this system and carcinogenicity in animals, these findings suggest that silver sulfadiazine is apparently also devoid of carcinogenic properties. | 1978 | 340170 |
| increased susceptibility of trypanosoma lewisi infected, or decomplemented rats to salmonella typhimurium. | rats infected with trypanosoma lewisi or decomplemented by injection of cobra venom factor or complement activating factor of trypanosomes were found to be more susceptible to infection with salmonella typhimurium. decomplemented rats subsequently infected with t. lewisi developed higher blood parasitemia than did normal t. lewisi infected rats. | 1978 | 340247 |
| mutagenic activity of thiocarbamate herbicides in salmonella typhimurium. | 1978 | 340488 | |
| the effect of defined lipopolysaccharide core defects upon antibiotic resistances of salmonella typhimurium. | 1977 | 340606 | |
| quinoline: conversion to a mutagen by human and rodent liver. | quinoline, a hepatocarcinogen in rats, and 23 quinoline derivatives were tested for mutagenic activity with the ames salmonella typhimurium assay. quinoline, 5-hydroxyquinoline, and 8-hydroxyquinoline were mutagenic in strain ta 100 when aroclor 1254-induced rat (male outbred sprague-dawley) liver homogenate was present in the incubation mixture. enzyme preparations from rats pretreated with p-448-dependent aryl hydrocarbon hydroxylase inducers [3-methylcholanthrene (mca) and beta-naphthoflavone ... | 1978 | 340706 |
| biochemical characteristics and in-vitro drug sensitivity of salmonella typhimurium, copenhagen variety isolated from domestic and feral pigeons, crows, a kite, chickens and animals in japan. | 1977 | 340743 | |
| an effect of f-like plasmids on the maintenance of flac in a dnac mutant of salmonella typhimurium. | flac maintenance was aberrant at permissive temperature in a temperature-sensitive dnac mutant of salmonella typhimurium when the normally resident plt2 plasmid was present. flac was, however, efficiently transferred into the dnac plt2+ strain and the resulting flac derivative was almost as efficient in transferring flac as was dnac+ plt2+ flac strains indicating that aberrant flac maintenance was not associated with appreciable inhibition of transfer replication. a range of f-like plasmids beha ... | 1977 | 340909 |
| the structure of the cyscdhij region in unstable cysteine or methionine requiring mutants of salmonella typhimurium. | a genetic method was devised to test the hypothesis that in some cysteine or methionine requiring (cym) mutants of salmonella typhimurium suppression of auxotrophy is due to an insertion at the site of the cym mutation. it was found that suppressed strains have an insertion of about 9kb in the cyscdhij region and that in unstable suppressed strains it is the instability of this insertion which results in the segregation of cym auxotrophs. | 1977 | 340911 |
| association of some enterobacteria with the intestinal mucosa of mouse in relation to their partition in aqueous polymer two-phase systems. | the association of enterobacteria with mouse intestinal mucosa has been investigated by pumping heat-killed, radioactively-labelled bacteria through the gut lumen in vitro. approximately 20 cm of the small intestine proximal to the ileo-caecal valve was rinsed, excised and maintained in an organ bath. by using two different bacteria labelled with different radioactive isotopes, the relative association of the two bacterial pumped through the same piece of gut was determined. cross-labelling show ... | 1977 | 341643 |
| endocytosis of salmonella typhimurium 395 ms and mr10 by hela cells. | monolayer of hela cells were examined for their ability to endocytose salmonella typhimurium 395 ms (wild) and mr10 (chemotype rd). monolayers treated with the glycolytic inhibitors iodoacetic acid (iaa) or n-ethylmaleimide (nem) or the respiratory inhibitor sodium azide (nan3) or cytochalasin b (cb) were incubated with s. typhimurium. the numbers of cell-associated (intracellular plus cell-membrane attached extracellular) and intracellular bacteria were determined by viable counts, together wit ... | 1977 | 341644 |
| [physiological characteristics of salmonella typhimurium treated with penicillin]. | growing bacteria of the two strains of salmonella typhimurium differing in the sensitivity levels to uv-light formed multinuclear non-septal filaments in the penicillin-containing nutrient medium. the maximum number of the lifefull filaments was formed by the 4th hour of incubation in the beaf-peptone broth at a temperature of 37 degrees c in the presence of 5 gamma/ml of penicillin. the strains exposed to penicillin were less sensitive to uv-light. exclusion of penicillin from the nutrient medi ... | 1978 | 341800 |
| the response of foetal sheep to the somatic and flagellar antigens of salmonella typhimurium. | following the injection of polymeric flagellin (pol), foetal sheep older than 70 days gestation produced haemagglutinating antibody and synthesized igm. the maximum titre of antibody in the blood increased with the age at which the foetus was injected. all foetuses synthesized 2-mercapto-ethanol-sensitive antibodies, while older foetuses (approximately 120 days gestation) also produced 2-mercaptoethanol-resistant antibodies and synthesized igg1. during the primary immune response, there was a po ... | 1977 | 341873 |
| sodium-dependent binding of p-nitrophenyl alpha-d-galactopyranoside to membrane vesicles isolated from salmonella typhimurium. | 1978 | 341975 | |
| mutagenicity of some congeners of benzidine in the salmonella typhimurium assay system. | the analogs of benzidine were assay for mutagenicity using salmonella typhimurium ta-98 and ta-100 and a mouse liver enzyme preparation. only 4-aminobiphenyl produced both frameshift and base pair substitution mutations and 3,3'-dichlorobenzidine was the only compound which was mutagenic without the mammalian enzyme factor. when hydrochloride salts of the parent compounds were made to improve their stability for animal feeding experiments, the mutagenicity for the salmonella tester strains was r ... | 1978 | 342090 |
| mutagenicity of carcinogenic mycotoxins in salmonella typhimurium. | 1978 | 342092 | |
| deficiency of serum bactericidal activity against salmonella typhimurium in sickle cell anaemia. | systemic salmonellosis is a recognized complication of sickle cell anemia (sca). in our initial study of sca host defences against salmonella, we evaluated the bactericidal activity of serum against salmonella typhimurium. when compared to controls, sera from eight out of nineteen sca patients were deficient in bactericidal function. levels of factor b, haemolytic complement and agglutinating antibody were similar in sca and control sera. however, abnormalities that might theoretically account f ... | 1977 | 342154 |
| antimutagenic effects of caffeine during nitrosoguanidine-induced mutagenesis of salmonella typhimurium cells and phages. | the effect of caffeine on nitrosoguanidine-induced mutagenesis of salmonella typhimurium and its p22 and l phages was studied. the detected mutations included phage "clear" mutations, reversions of phage "amber" mutation, and prototrophic reversions of the his- auxotroph of salmonella typhimurium. neither the reca mutation of the host nor the erf mutation of the phage genome were found to affect the nitrosoguanidine-induced mutagenesis of the phage during vegetative growth. beginning with a conc ... | 1978 | 342372 |
| o antigen as virulence factor in mouse typhoid: effect of b-cell suppression. | immunosuppression by cyclophosphamide was used to make mice incapable of b-lymphocyte responses; they could not make an antibody response to nip-ficoll. these mice, as well as untreated mice, were challenged intraperitoneally with graded doses of isogenic o-4,12 or o-6,7 salmonella typhimurium derivatives. the 50% lethal dose of the o-6,7 strains was 35- to 70-fold higher than that of the o-4,12 strains, both in the normal and the immunosuppressed animals, although the latter were approximately ... | 1978 | 342413 |
| influence of oral antibiotic feeding on the duration and severity of clinical disease, growth performance, and pattern of shedding in swine inoculated with salmonella typhimurium. | 1978 | 342469 | |
| expression of escherichia coli fol alleles in salmonella typhimurium. | studies of the expression of escherichia coli fol alleles in salmonella typhimurium indicated that fol regulatory functions are highly conserved between these bacterial species. | 1978 | 342487 |
| chemotaxis of salmonella typhimurium to amino acids and some sugars. | patterns of chemotaxis by salmonella typhimurium strain lt-2 to l-amino acids and to several sugars were quantitated by the adler capillary procedure. competition experiments indicated that lt-2 possesses three predominant receptors, or interacting sets of receptors, for amino acids. these were termed the aspartate, serine, and alanine classes, respectively. studies with strains carrying point and deletion mutations affecting components of the phosphoenolpyruvate: glycose phosphotransferase syst ... | 1978 | 342504 |
| regulation of the major proline permease gene of salmonella typhimurium. | the structural gene for the major proline permease is located in a tight cluster with genes coding for the proline degradative enzymes, proline oxidase and pyrroline-5-carboxylic acid dehydrogenase. expression of the permease is regulated in parallel with the two degradative enzymes, and all three functions are subject to catabolite repression. regulatory mutants (putc) have constitutively high levels of all three activities, suggesting that all are regulated by a single mechanism. | 1978 | 342506 |
| cluster of genes controlling proline degradation in salmonella typhimurium. | a cluster of genes essential for degradation of proline to glutamate (put) is located between the pyrc and pyrd loci at min 22 of the salmonella chromosome. a series of 25 deletion mutants of this region have been isolated and used to construct a fine-structure map of the put genes. the map includes mutations affecting the proline degradative activities, proline oxidase and pyrroline-5-carboxylic dehydrogenase. also included are mutations affecting the major proline permease and a regulatory mut ... | 1978 | 342507 |
| promoter- and attenuator-related metabolic regulation of the salmonella typhimurium histidine operon. | expression of the histidine (his) operon in salmonella typhimurium was found to be positively correlated with the intracellular level of guanosine tetraphosphate (ppgpp). limitation for amino acids other than histidine elicited a histidine-independent metabolic regulation of the operon. in bacteria grown at decreased growth rates, his operon expression was metabolically regulated up to a point, after which further decreases in growth rate no longer resulted in further enhancement of operon expre ... | 1978 | 342509 |
| incomplete flagellar structures in nonflagellate mutants of salmonella typhimurium. | incomplete flagellar structures were detected in osmotically shocked cells or membrane-associated fraction of many nonflagellate mutants of salmonella typhimurium by electron microscopy. the predominant types of these structures in the mutants were cistron specific. the incomplete basal bodies were detected in flafi, flafiv, flafviii, and flafix mutants, the structure homologous to a basal body in flafv mutants, the polyhook-basal body complex in flar mutants, and the hook-basal body complex in ... | 1978 | 342514 |
| threonine deaminase from salmonella typhimurium. effect of regulatory ligands on the binding of substrates and substrate analogues to the active sites and the differentiation of the activator and inhibitor sites from the active sites. | 1978 | 342520 | |
| biosynthesis of lipid a. enzymatic incorporation of 3-deoxy-d-mannooctulosonate into a precursor of lipid a in salmonella typhimurium. | the cell envelope fraction of salmonella typhimurium contains an enzyme system which catalyzes transfer of 3-deoxyoctulosonate (kdo) from cmp-kdo to an incomplete, kdo-deficient precursor of lipid a. the enzyme system is firmly membrane-bound, but has been solubilized by treatment with nonionic detergent at alkaline ph and partially purified. both the particulate and partially purified fractions catalyzed formation of a single reaction product containing 2 residues of kdo. periodate oxidation of ... | 1978 | 342527 |
| the epidemiology and genetics of antibiotic resistance of salmonella typhimurium isolated from diseases animals in new york. | only 12% of 249 strains of salmonella typhimurium isolated during the period 1973-1976 from diseased animals were sensitive to six commonly used antibiotics. isolates from calves exhibited the highest frequency of resistance as well as a steadily increasing frequency of resistance to ampicillin and chloramphenicol. the majority of strains from horses, dogs, and cats were also resistant to more than one antibiotic, a finding which was interpreted as primarily an effect of therapeutic rather than ... | 1978 | 342636 |
| the use of strain lt2-ml in identifying the protective antigens in a salmonella typhimurium-derived ribosomal vaccine. | 1978 | 342689 | |
| immunological properties of vibrio cholerae lipopolysaccharides. | immunological effects of wall lipopolysaccharide (lps) preparations obtained from vibrio cholerae inaba 569b, ogawa nih 41 and nag 4715 strains by the hot phenol-water procedure were examined in mice. although these lps lack kdo, which are basic components of the core region of most gram-negative lps, they still have potencies as b-cell mitogens, adjuvants, immunosuppressants, polyclonal b-cell activators and phagocytic stimulants for macrophages. the activities of these v. cholerae lps on murin ... | 1977 | 342874 |
| re-initiation of tryptophan operon expression in a promoter deletion strain of salmonella typhimurium. | a genetic and enzymological study was made of five spontaneous prototrophic revertants of a tryptophan auxotroph of salmonella typhimurium which carries a deletion extending from the closely linked supx locus into the trp operator-promoter region. the revertants were found to have regained initiation of expression of all five trp genes. recombinational tests showed that in each case the genetic change responsible for re-initiation is cotransducible with the trp-cysb region of the chromosome. two ... | 1978 | 342912 |
| high mutagenicity of n-(alpha-acyloxy)alkyl-n-alkylnitrosamines in s. typhimurium: model compounds for metabolically activated n,n-dialkylnitrosamines. | a series of n,n-dialkylnitrosamines (alkyl means methyl, ethyl, n-propyl, n-butyl or tert-butyl group) mono-substituted at the alpha-carbon with an acetoxy group, were tested for their mutagenic action in salmonella typhimurium ta1530 in the presence or absence of a rat-liver supernatant from 9000 x g. the presumed released of methyl, ethyl, n-butyl and n-propyl carbonium ions from the corresponding alpha-acetoxy derivatives, either by enzymic cleavage or by non-enzymic hydrolysis of the ester g ... | 1978 | 342933 |
| evaluation of the mutagenic potential of mycotoxins using salmonella typhimurium and saccharomyces cerevisiae. | the mutagenic effects of fiteen mycotoxins on salmonella typhimurium strains ta1535, ta1537 and ta1538 and saccharomyces cerevisiae strain d-3 were tested. only aflatoxin b1 and sterigmatocystin were mutagenic. both were active against s. typhimurium strain ta1538 and s. cerevisiae strain d-3; however, both required activation by the hepatic s-9 enzyme preparation. a positive correlation between the other mycotoxins reported to be carcinogenic and the two in vitro test systems employed was not d ... | 1978 | 342938 |
| mutagenicity of alkyl-(omega-hydroxyalkyl) nitrosamines related to dibutylnitrosamine. | various alkyl-(omega-hydroxyalkyl) derivatives related to dibutylnitrosamine (dbn) were investigated for mutagenicity in the absence of liver-activation system. butyl-(4-hydroxybutyl)-, butyl-(3-hydroxypropyl)-, and butyl-(2-hydroxyethyl)-nitrosamines were so tested and found to be mutagenic for ta 1535 strain of salmonella typhimurium. in all cases, a simple dose-response relationship was observed. furthermore, no significant (p less than 0.05) differences in the mutagenicity of the various tes ... | 1978 | 342939 |
| mutagenic effect of dichloromethane on salmonella typhimurium. | the possible mutagenicity of the organic solvent dichloromethane was investigated with the mutation test as described by ames et al. the compound was mutagenic in both tester strains used, namely ta98 and ta100. the administration of rat-liver homogenate did not appear to be essential though it slightly increased the number of mutations. | 1978 | 342942 |
| mutagenicity in salmonella typhimurium mutants of the benzene-soluble organic matter derived from air-borne particulate matter and its five fractions. | air-borne particulate matter was collected on a filter, then extracted with benzene. the benzene-soluble material was separated into 5 fractions, namely acidic, basic, alipathic, polyaromatic and oxygenated fractions. the mutagenic activities of these fractions were examined with a set of salmonella typhimurium mutants. the 6 mutants were from the ta1535 series, deep rough strains without excision repair, namely ta100 and ta98 (having a resistance-transfer factor) and the standard strain ta1535, ... | 1978 | 342944 |
| mutagenicities of the pyrolyzates of peptides and proteins. | pyrolyzates of 10 peptides, 10 proteins and 5 naturally-occurring materials were tested for mutagenicity in the histidine-requiring mutants salmonella typhimurium ta98 and ta100. significant mutagenic activity was detected with pyrolyzates of most of these materials. the pyrolyzates requred a liver microsomal fraction, as representative of mammalian metabolism, for their detection as mutagens. among the pyrolyzates tested, the highest mutagenic activity was observed with that of a tryptophan-con ... | 1978 | 342945 |
| mutagenicity induced by lyophilization or storage of urine from isoniazid-treated rats. | urine collected during 24 h after treatment of rats with 90--550 mg/kg isonicotinic acid hydrazide (isoniazid, inh) was after lyophilization, mutagenic for salmonella typhimurium ta1535. urine collected directly from bladders of inh-treated rats was not mutagenic, and solutions of inh in water or urine became mutagenic only after lyophilization. in the absence of lyophilization, sterile urine from inh-treated rats became mutagenic after 8--14 days' storage at room temperature. | 1978 | 342946 |
| degeneration of the mucosal surface of the small intestine of the chicken in salmonella infection. | day-old chicks were infected with salmonella typhimurium. the impact on the intestinal mucosa was observed by scanning and transmission electron microscopy. salmonella infected birds were characterized as having areas on their intestinal mucosal cells devoid of microvilli. the absence of microvilli probably interferes with absorption of the digesta. | 1977 | 343083 |
| effect of low level feeding chlortetracycline on subsequent therapy of chicks infected with salmonella typhimurium. | a six-week trial was conducted to determine if therapeutic use of chlortetracycline (ctc) would be affected by previous use of the same antibiotics at subtherapeutic levels in the feed. results indicated therapeutic effect of ctc on mortality was not compromised by the previous use of the low level antibiotic. | 1977 | 343088 |
| quantitative forward mutation assay in salmonella typhimurium using 8-azaguanine resistance as a genetic marker. | we have developed a quantitative forward mutation assay using salmonella typhimurium, in which resistance to the purine analog 8-azaguanine is used as a genetic marker. we present the assay protocol, the concentration-dependent toxicity and mutagenicity of five known mutagens (n-methyl-n'-nitro-n-nitrosoguanidine, icr-191, 9-aminoacridine, dimethylnitrosamine, and benzo[a]pyrene), and reconstruction experiments testing the assay for possible bias. the relative merits of forward versus reverse mu ... | 1978 | 343109 |
| [further studies on the metabolic changes in salmonella typhimurium and yersinia pseudotuberculosis strains after treatment with detergents and lipid solvents]. | 1977 | 343513 | |
| nematospiroides dubius as a vector for salmonella typhimurium. | salmonella typhimurium within the 3rd stage larvae of nematospiroides dubius was shown to infect mice, evidenced by prolonged shedding of salmonellae in the feces. numbers of s typhimurium needed to infect mice were approximately 1,000- fold less if incorporated within the 3rd-stage larvae of n dubius. results of these experiments demonstrate that nematode parasites may act as a vector for pathogenic species of enteric bacteria. | 1978 | 343664 |
| [ulterior acquisitions regarding the salmonellosis (author's transl)]. | the authors report the results of the bacteriological researches on the incidence of the salmonella of our zone, after a brief consideration of general aspects salmonellosis. our observations are refered to 1005 samples of feces of which 84 cases proved positive to salmonella. it is pointed out that morbidity, represented by salmonella typhi, paratyphi a and b is low, while it is high for the salmonella typhimurium and salmonella enteritidis. the authors conclude stating that epidemiological sit ... | 1977 | 343729 |
| vaccination control of an outbreak of salmonella typhimurium infection in suckler cows and calves. | 1977 | 343876 | |
| experimental infection of point-of-lay and in-lay pullets with salmonella typhimurium. | 1978 | 343883 | |
| comparative efficacy and toxicity of a ribosomal vaccine, acetone-killed cells, lipopolysaccharide, and a live cell vaccine prepared from salmonella typhhimurium. | the protective and toxic properties of a ribosomal vaccine prepared from salmonella typhimurium w118-2 were systematicaly compared with those of an acetone-killed whole cell vaccine, purified lipopolysaccharide, and living cells in cd-1 mice. tests of graded immunizing doses of each vaccine against several challenge doses of live strain w118-2 showed that, although the protection given by ribosomes approached the levels of protection conferred by living organisms, acetone-killed cells administe ... | 1978 | 344216 |
| the effect of antimicrobial feed additives on the colonization of the alimentary tract of chickens by salmonella typhimurium. | groups of 33 chickens were fed continuously on diets containing feed additives that are employed commercially for a variety of purposes, and were infected orally when 4 days old with a nalidixic acid-resistant mutant of salmonella typhimurium. the amount of s. typhimurium organisms excreted in their faeces was estimated by culturing them at intervals and in a standard manner on brilliant green agar containing sodium nalidixate; when the chickens were killed their caecal contents were examined by ... | 1978 | 344789 |
| tandem chromosomal duplications in salmonella typhimurium: fusion of histidine genes to novel promoters. | 1978 | 344891 | |
| molecular studies of fime resistance plasmids, particularly in epidemic salmonella typhimurium. | 1978 | 345079 | |
| superinfection exclusion and changes in cellular transport processes in phage infected salmonella typhimurium. | the changes induced by bacteriophage p22 in the cellular transport process(es) of the host salmonella typhimurium (taneja et al., 1975; khandekar et al., 1975; bandyopadhyay and chakravorty, 1976) involve interactions between the superinfection exclusion system of the resident prophage and the c immunity region of the superinfecting phage. the sie a gene of the prophage interferes with the changes in the cellular transport process induced by the superinfecting phage. however, if the superinfecti ... | 1978 | 345099 |
| chloramphenicol-resistant salmonella typhimurium. | 1978 | 345599 | |
| [transfer of multi-drug resistance in vivo by salmonellae and shigella in white mice]. | the oral infection accomplished by 0.3 cm3 x 10(10) microbial bodies of salmonella heidelberg and shigella sonnei in albino mice the pathogens were found to localize in the intestines. the salmonellae were detected up to the 10th day, and the shigellae--up to the 14th day. both shigella and salmonella transferred multi-drug resistance to some enterobacteria--e. coli and proteus as well as to salmonella typhimurium when the latter was also present in the intestinal tract; of these some 10--40 per ... | 1977 | 345607 |
| sulphate permease of escherichia coli k12. | some properties of the sulphate transport system and the isolation of sulphate permease mutants in e. coli k12 are described. the gene coding for sulphate permease is located in the same region as the cysa gene in salmonella typhimurium. | 1977 | 345700 |
| salmonella typhimurium pancreatic abscess: report of a case. | a case of pancreatic abscess from salmonella typhimurium is reported. after surgical drainage of the abscess, positive stool cultures persisted. finally, after intensive antimicrobial therapy with tetracycline and chloramphenicol, and cholecystectomy, stool cultures became negative. this is, to our knowledge, the first published case of s. typhimurium pancreative abscess. | 1978 | 345903 |
| recovery of sublethally heat-injured salmonella typhimurium on supplemented plating media. | the efficacy of 32 additives to levine eosin-methylene blue-salts agar medium (embs) for the recovery of sublethally heat-injured salmonella typhimurium was evaluated. in order of decreasing effectiveness, lactate, mannitol, and alpha-glycerophosphate mediated 90% or more recovery of injured cells; similar levels of recovery were obtained on embs supplemented with 1% (wt/vol) tryptic soy broth, protease peptone, or plate count agar. other additives showed little or no capacity for repair or stro ... | 1978 | 345969 |
| mechanisms of bacterial mutagenesis and properties of mutagenesis tester strains. | bacterial tester strains are available which can detect base pair substitution, frameshift and deletion mutations. i consider possible mechanisms for these types of event. i describe the four main types of dna repair process operating in escherichia coli and salmonella typhimurium and how they may influence mutation: means of modifying repair processes to increase the sensitivity of tester strains are discussed. the properties of some current strains are briefly described. i comment adversely on ... | 1978 | 346007 |
| the measurement of bacterial translation by photon correlation spectroscopy. | photon correlation spectroscopy is shown to be a practical technique for the accurate determination of translational speeds of bacteria. though other attempts have been made to use light scattering as a probe of various aspects of bacterial motility, no other comprehensive studies to establish firmly the basic capabilities and limitations of the technique have been published. the intrinsic accuracy of the assay of translational speeds by photon correlation spectroscopy is investigated by analysi ... | 1978 | 346073 |