Publications
| Title | Abstract | Year Filter | PMID(sorted ascending) Filter |
|---|
| historical study: johann gregor mendel 1822-1884. | the life and personality of johann gregor mendel (1822-1884), the founder of scientific genetics, are reviewed against the contemporary background of his times. at the end are weighed the benefits for mendel (as charged by sir ronald fisher) to have documented his results on hand of falsified data. mendel was born into a humble farm family in the "kuhländchen", then a predominantly german area of northern moravia. on the basis of great gifts mendel was able to begin higher studies; however, he f ... | 1991 | 1887835 |
| a brain-stem lesion in the miller fisher syndrome demonstrated by ct and mri. | 2005 | 1895158 | |
| selective heparinization of venous anastomosis in latissimus dorsi free flaps to cover lower-extremity soft-tissue defects. | two groups of consecutive patients treated with latissimus dorsi free myocutaneous flaps to cover lower-extremity soft-tissue defects were compared for postoperative vascular occlusion. in the first group of 13 patients (group i), there were five (38%) venous occlusions and no arterial occlusions. the second group of 15 patients (group ii) was treated with selective heparinization of each venous anastomosis via a 0.35" catheter sutured into the serratus branch of the donor vein. in this group on ... | 2007 | 1895940 |
| [late recurrence of miller-fischer syndrome. physiopathogenic reflections about a case]. | the physiopathology of the syndrome of ophtalmoplegia-ataxia-areflexia-hyperproteinorachia, firstly described by fisher in 1956, remains a matter of controversy among neurologists. we report a new case of recurrence of a miller-fisher's syndrome. the involvement of peripheral and central structures is discussed according to recent knowledges about the immunopathology of inflammatory polyneuropathies. | 2016 | 1896715 |
| treatment of corneal allograft rejection with the cytotoxin il-2-pe40. | il-2-pe40 is a recombinant chimeric protein composed of il-2, fused to a modified pseudomonas exotoxin. this molecule is extremely toxic to activated t cells expressing high-affinity il-2r. we used this new molecule for selective immunosuppression to treat corneal allograft rejection in the rat, using fisher and lewis rats, a strain combination differing only in medial and minor histocompatibility antigens. the effect of il-2-pe40 on the immunologic response was studied using both a heterotopic ... | 1991 | 1897019 |
| does exercise stress alter susceptibility to bacterial infections? | swimming was used for evaluating alterations in performance capacity and as a means for studying the influence of exercise stress on susceptibility to streptococcus pneumoniae and francisella tularensis infections in two strains of rats, i.e. fisher-dunning (fd) and sprague-dawley (sd). the performance capacity was reduced by both diseases and was correlated to the dose of the given micro-organism. fd rats, however, were more susceptible to the infection and showed a greater deterioration than s ... | 1991 | 1897063 |
| the role of cytophilic igg3 antibody in t cell-mediated resistance to infection with the extracellular bacterium, pseudomonas aeruginosa. | previous studies have demonstrated that t lymphocytes from mice immunized with a high m.w. polysaccharide ag from fisher-devlin immunotype i pseudomonas aeruginosa can adoptively transfer protection against challenge with the homologous bacterial strain to susceptible mice. this t cell-mediated resistance has been found to be b cell dependent, although serum from immunized mice is incapable of passively transferring protection to nonimmune mice. the current studies demonstrate that t cells from ... | 1991 | 1898604 |
| the effect of duodenojejunal alimentation on gastric ph and hormones in intensive care unit patients. | we evaluated effects of duodenojejunal (dj) feeding on gastric ph and selected gastrointestinal hormones in 13 randomly selected patients in an intensive care unit (icu). to obtain baseline values for gastric ph, a nasogastric (ng) tube was placed in each patient and gastric ph was measured every 30 minutes for 2 hours. to obtain control values, a dobbhoff tube was placed fluoroscopically and 0.45 percent saline solution (nacl), 75 ml, was infused for 1 hour and gastric ph was measured again; th ... | 1991 | 1899823 |
| norepinephrine and isoproterenol increase the phosphorylation of synapsin i and synapsin ii in dentate slices of young but not aged fisher 344 rats. | a number of recent reports have suggested that norepinephrine (ne) produces a form of synaptic enhancement that resembles long-term potentiation (ltp). ltp, thought to be an electrophysiological correlate of memory, in part involves an augmentation of transmitter release. although the effects of ne have not been unequivocally linked to ltp, it is clear that ne can produce increased transmitter release in the dentate gyrus of the hippocampus. the purpose of this study was to determine whether ne ... | 1991 | 1900942 |
| growth characteristics and metastatic potential of seven intestinal carcinoma lines serially passaged in syngeneic rats. | transplantable tumour lines were obtained from one duodenal carcinoma induced by n-methyl-n'-nitro-n-nitrosoguanidine in the lewis rat and from six colonic carcinomas induced by 1,2 dimethylhydrazine in bdix or fisher rats. the tumours were serially transplanted by the subcutaneous route into homologous syngeneic rats. the seven tumours differ from one another in their histological structure, five of them being well or moderately differentiated adenocarcinomas, and in their capacity to produce n ... | 1991 | 1900965 |
| antiphospholipid antibodies and recurrent abortion. | we examined the association between anticardiolipin antibodies, lupus anticoagulant, and the risk of recurrent spontaneous abortion in a case-control study conducted in a network of general and teaching hospitals in northern italy. subjects consisted of 220 women with two or more unexplained consecutive spontaneous abortions and 193 controls admitted for acute conditions other than immunologic, infective, gynecologic, or cardiovascular. lupus anticoagulant was detected in 16 of 220 cases (7%, 95 ... | 1991 | 1903191 |
| organochlorine insecticide and polychlorinated biphenyl residues in martens and fishers from the algonquin region of south-central ontario. | 1991 | 1903314 | |
| structural characterization of the lipid a component of pseudomonas aeruginosa wild-type and rough mutant lipopolysaccharides. | the structure of the lipid a component of lipopolysaccharides isolated from two wild-type strains (fisher 2 and 7) and one rough mutant (pac 605) of pseudomonas aeruginosa was investigated using chemical analysis, methylation analysis, combined gas-liquid chromatography/mass spectrometry, laser-desorption mass spectrometry and nmr spectroscopy. the lipid a backbone was found to consist of a pyranosidic beta 1,6-linked d-glucosamine disaccharide [beta-d-glcpn-(1----6)-d-glcpn], phosphorylated in ... | 1991 | 1904818 |
| variable selection for the classification of postoperative cardiac patients. | a set of 13 extensively used hemodynamic, ventilatory and gas analysis variables are measured (on-line or off-line) on 200 patients in an intensive care unit (icu) during the 6 h immediately following cardiac surgery. since the existence of two well-separated classes of low- and high-risk patients has been previously shown the divergence criterion is then used to identify those variables which, at three equidistant observation times, possess the greatest separation power. such variables always i ... | 2013 | 1904843 |
| characterization of the mutation responsible for aspartylglucosaminuria in three finnish patients. amino acid substitution cys163----ser abolishes the activity of lysosomal glycosylasparaginase and its conversion into subunits. | the mutation that causes a deficiency of the lysosomal amidase, glycosylasparaginase, has been characterized in fibroblasts from three finnish patients diagnosed with aspartylglucosaminuria (agu). the polymerase chain reaction was used to amplify the glycosylasparaginase protein coding sequence from the three agu patients in order to compare them to the normal sequence from a full-length human placenta cdna clone hpasn.6 (fisher, k.j., tollersrud, o.k., and aronson, n.n., jr. (1990) febs lett. 2 ... | 1991 | 1904874 |
| prevention of vasospasm by clot removal and intrathecal bolus injection of tissue-type plasminogen activator: preliminary report. | in this study, we evaluated the efficacy of postoperative intrathecal injections of tissue-type plasminogen activator (tpa) in preventing cerebral vasospasm in cases with a diffuse severe subarachnoid hemorrhage. all 10 cases were graded group 3 according to the classification of fisher and associates, and the ct number (hounsfield number) of the subarachnoid clot was over 75. after clipping the aneurysm and removing the clot, three cisternal drainage catheters were inserted into both sylvian ci ... | 1991 | 1906142 |
| phase i trial of tissue plasminogen activator for the prevention of vasospasm in patients with aneurysmal subarachnoid hemorrhage. | recent laboratory studies have demonstrated that intracisternal administration of recombinant tissue plasminogen activator (rt-pa) can facilitate the normal clearing of blood from the subarachnoid space and prevent or ameliorate delayed arterial spasm. the results of a preliminary phase i trial of intracisternal rt-pa in 10 patients are reported with documented aneurysmal subarachnoid hemorrhage (sah). all patients enrolled were classified as clinical grade iii or iv (according to hunt and hess) ... | 1991 | 1906534 |
| functional enhancement of intrastriatal dopamine-containing grafts by the co-transplantation of sciatic nerve tissue in 6-hydroxydopamine-lesioned rats. | peripheral nerve "bridges" demonstrate the ability to facilitate axonal growth and regenerate adult and fetal central nervous system tissue. the purpose of this study was to determine if co-grafted peripheral nerve tissue could enhance the ability of fetal dopamine (da) cell transplants to reinnervate host striatum that had been denervated unilaterally. male fisher-344 rats were unilaterally lesioned with 6-hydroxydopamine to eliminate the nigrostriatal da pathway. a total of 31 rats demonstrate ... | 1991 | 1907926 |
| enhancement of pulmonary tumour seeding by human coagulation factors ii, ix, x--an investigation into the possible mechanisms involved. | warfarin inhibits metastasis in the animal model and injection of the warfarin-dependent coagulation factor complex ii, ix, x enhances pulmonary metastasis in the same model. we have studied two possible mechanisms responsible for the observed effect. mtln3, rat mammary carcinoma cells, radiolabelled with 5-(125) iodo-2'-deoxyuridine (iudr) were injected intravenously in female fisher 344 rats either alone or in combination with factor complex ii, ix, x or bovine serum albumin. following sacrifi ... | 1991 | 1911192 |
| successful 2-week treatment with terbinafine (lamisil) for moccasin tinea pedis and tinea manuum. | a new orally active antifungal agent, terbinafine, was used in the treatment of tinea pedis ('dry type' or moccasin type) and tinea manuum. fifty-three adults over the age of 16 years with fungal infections of the feet and/or hands were treated with either oral terbinafine, 250 mg, or placebo, once daily for 2 weeks. the diagnosis of fungal infection was confirmed by examination of skin scrapings by microscopy and culture. of these, 28 patients were evaluable for efficacy. at 8 weeks, 12 out of ... | 1991 | 1911319 |
| elective oral tracheal intubation in cervical spine-injured adults. | there is controversy regarding the optimal mode of elective tracheal intubation in the patient with an unstable cervical spine following trauma. a ten-year review of 150 patients with traumatic cervical spine injuries with well-preserved neurological function, presenting for operative stabilization, was conducted to compare neurological outcome with the mode of tracheal intubation. preoperative neurological deficits were identified in 49 patients (33%); most were single-level radiculopathies. in ... | 2007 | 1914066 |
| the structure of genealogies and the distribution of fixed differences between dna sequence samples from natural populations. | when two samples of dna sequences are compared, one way in which they may differ is in the presence of fixed differences, which are defined as sites at which all of the sequences in one sample are different from all of the sequences in a second sample. the probability distribution of the number of fixed differences is developed. the theory employs wright-fisher genealogies and the infinite sites mutation model. for the case when both samples are drawn randomly from the same population it is foun ... | 1991 | 1916247 |
| hearing loss and ear disorders in malaysian school children. | in malaysia 1,307 randomly selected primary school children were screened to find out the prevalence of hearing loss and middle ear disorders. seventy-six students (5.81%) failed the screening audiometric test. there were 95 students (7.26%) with middle ear disorders. history of ear discharge was absent in 24 out of 57 cases with csom (42.11%) (p less than 0.001). forty-three out of 95 children having middle ear disorders passed the screening audiometric test (p less than 0.01 fisher exact test) ... | 1991 | 1917340 |
| biochemical quantitation and histochemical localization of glucose-6-phosphate dehydrogenase activity in the olfactory system of adult and aged rats. | the activity of glucose-6-phosphate dehydrogenase, the rate-limiting enzyme of the hexose monophosphate shunt, was examined in olfactory epithelium, respiratory epithelium, olfactory bulb, and occipital cortex in fisher 344 rats aged 4 and 24 months. marked differences in this enzyme were found in olfactory compared to nonolfactory tissues. olfactory epithelium and olfactory bulb have much greater glucose-6-phosphate dehydrogenase activity than respiratory epithelium and occipital cortex at both ... | 1991 | 1922658 |
| the effect of hypertonic saline resuscitation on bacterial translocation after hemorrhagic shock in rats. | translocation of enteric bacteria occurs in rats after hemorrhagic shock. a proposed mechanism involves intestinal mucosal injury by hypoperfusion. recent work suggests that moderate hypovolemia causes gut arteriolar constriction, which is ameliorated by hypertonic saline resuscitation. bacterial translocation should, therefore, be reduced when hypertonic saline (hs) is used as the resuscitative fluid. seventy-eight sprague-dawley rats were anesthetized and subjected to 30 minutes of hemorrhagic ... | 1991 | 1925957 |
| strain-related differences in airway smooth muscle and airway responsiveness in the rat. | the purpose of this study was to evaluate the possible role of the quantity of airway smooth muscle (awsm) as a determinant of differences in responsiveness between inbred rat strains. to do this, we studied several batches of 8- to 10-wk-old lewis and fisher 344 rats. animals were anesthetized intraperitoneally with pentobarbital (30 mg/kg) and xylazine (7 mg/kg). the peak value of pulmonary resistance (rl) was measured after progressively doubling concentrations of inhaled aerosolized methacho ... | 1991 | 1928950 |
| [recurrent miller-fisher associated with non-defined systemic disease]. | 2004 | 1931107 | |
| absence of lutropin (lh) receptor mrna in the rat thyroid: further evidence for specificity cross-over at the thyroid-stimulating hormone receptor level. | chorionic gonadotropin (cg) and purified lutropin (lh) activate intact thyroid tissue and isolated thyroid cells. a recent report has suggested that the presence of aberrant lh/cg receptors in human and rat thyroid tissue may interact with gonadotropin thus explaining the mechanisms of thyroid cell stimulation. to detect putative thyroidal lh receptor mrna, a segment of the transmembrane region containing domains 3 through 6 of the rat (r) lh receptor was targeted for amplification using the pol ... | 1991 | 1936543 |
| lewontin and kojima meet fisher: linkage in a symmetric model of sex determination. | the effect of linkage and epistasis on the evolution of the sex-ratio is studied in a symmetric two-locus model of autosomal sex determination closely related to the symmetric viability model of r. c. lewontin and k. kojima. r. a. fisher's expectation of an even sex ratio for autosomal sex determination by a single gene governs the dynamics when the loci are tightly linked. however, recombination may preclude optimization of the sex ratio just as occurs in viability selection models. many of the ... | 1991 | 1936963 |
| single-dose tumor necrosis factor protection against endotoxin-induced shock and tissue injury in rats. | tumor necrosis factor (tnf), a macrophage product released in response to endotoxin and other stimuli, has been shown to be a central mediator of endotoxin or septic shock. however, its highly conserved and wide-ranging physiological effects suggest that it may also be an essential cytokine in the host defense against acute bacterial infection or sepsis. a single nontoxic dose of human recombinant tnf administered intravenously 24 h prior to a lethal infusion of escherichia coli lipopolysacchari ... | 1991 | 1937748 |
| isonymy in records of births and deaths in ferrara. | surname distributions were studied in records of male and female births in ferrara in the period 1982-89, and in records of male and female deaths in the same period. average year of birth and standard deviation was 1985 +/- 2.3 for the birth series, and 1912 +/- 14.4 for the death series. then the surname distributions, in two independent samples at an average distance of 73 years, were compared. it was observed that random isonymy within series, which depends on the shape of the distribution, ... | 1991 | 1952797 |
| influence of proliferation on dna repair rates in liver. | to test the hypothesis that the proliferative status of a mammalian cell determines the rate of removal of oxidative dna damage, pre- and posthepatectomized livers in adult male fisher 344 rats were irradiated in situ with 15.5 gy of 137cs-gamma-rays. at 10 and 45 min after irradiation, the livers were removed and dissociated into single cell suspensions, and the dna damage in the isolated quiescent or proliferative liver cells was assayed by alkaline elution. proliferative liver cells irradiate ... | 1991 | 1959564 |
| aging does not alter muscarinic receptor-mediated inhibition of cyclic amp formation in the striatum and hippocampus. | the effects of aging on the inhibition of forskolin-stimulated cyclic amp formation by muscarinic receptors were investigated. there were no detectable changes in the magnitude of maximal inhibition by carbamylcholine or the potency of the agonist in inducing this response in either the striatum or hippocampus obtained from young or old fisher 344 rats. | 1990 | 1963561 |
| miller-fisher syndrome and pontine abnormalities on mri: a case report. | the authors report a patient with miller-fisher syndrome in whom mri of the brain stem showed increased signal density on t2 sequence anterior to the fourth ventricle, on the right and the left. the authors discuss the relation between these mri abnormalities and some clinical features of the syndrome. the authors believe that the cardinal features of miller-fisher syndrome are due to peripheral nervous system dysfunction, but that this does not preclude a possible central nervous system involve ... | 1990 | 1963636 |
| reduced high-affinity alpha 1-adrenoceptors in liver of senescent rats: implications of assessment at various temperatures. | 1. we investigated the changes occurring as a result of aging in alpha 1-adrenoceptors in the livers of fisher 344 females rats. for comparison, we also measured beta-adrenoceptors in this tissue. three age groups were studied, including young adults (aged 6 months), mature adults (aged 16 months) and senescent animals (aged 25 months). 2. the density of alpha 1-receptors was measured by use of [3h]-prazosin and was found to be reduced 39% (p less than 0.01) at 25 months compared with 6 months. ... | 1990 | 1963803 |
| treatment of humoral hypercalcemia of malignancy in rats with inhibitors of carbonic anhydrase. | the enzyme carbonic anhydrase has been suggested as a critical participant in osteoclast-mediated bone resorption. in humoral hypercalcemia of malignancy (hhm) intense osteoclastic bone resorption is principally responsible for the observed hypercalcemia. we therefore undertook to examine the effect of the carbonic anhydrase inhibitor acetazolamide on the hypercalcemia induced by the h500 leydig cell tumor in fisher rats, a well-described model of hhm. acetazolamide treatment for 10 h at 10 mg/h ... | 1990 | 1964358 |
| hemodynamic effects of 1-[3,4-dihydroxyphenyl]-1,2-diaminoethane versus norepinephrine during ventricular fibrillation and cardiopulmonary resuscitation. | we hypothesized that substitution of the hydroxyl group (oh) on the beta carbon of norepinephrine (ne) with an amino group would yield a compound, 1-(3,4-dihydroxyphenyl)-1,2-diaminoethane (dhpdae), that would maintain the hemodynamic properties of ne during cpr, but would decrease the rate of post-defibrillation dysrhythmias. six mixed breed swine weighing greater than 28 kg were studied. the animals were instrumented for cerebral (cbf) and myocardial blood flow (mbf) measurements. ventricular ... | 1990 | 1965347 |
| evidence for tripeptide-proton symport in renal brush border membrane vesicles. studies in a novel rat strain with a genetic absence of dipeptidyl peptidase iv. | we have investigated the transport characteristics of l-phenylalanyl-l-prolyl-l-alanine in renal brush-border membrane vesicles isolated from japan fisher 344 rats. this particular rat strain genetically lacks dipeptidyl peptidase iv. owing to the absence of this enzyme, the tripeptide was found to be completely resistant to hydrolysis by the renal brush-border membrane vesicles. uptake of the tripeptide into these membrane vesicles in the presence of an inwardly directed na+ gradient was slight ... | 1990 | 1967607 |
| chemical structure and genotoxic activity of the hepatocarcinogenic beta-blocker dl-zami 1305. | a single administration of the sex-dependent hepatocarcinogenic beta-blocker dl-1-(2-nitro-3-methyl-phenoxy)3-tert-butylamino-propan-2-ol (dl-zami 1305) induces liver dna damage, as evaluated by alkaline sucrose gradient analysis, in female but not in male fisher 344 rats. the shift of the methyl-group from the 3-position of the aromatic ring of dl-zami 1305 to the 4- and 5-position causes the progressive decrease of the genotoxic activity of the molecule. no effect on the dna-damaging capacity ... | 1990 | 1967984 |
| cloning of malignantly transformed rat thyroid (frtl) cells with thyrotropin receptors and their growth inhibition by 3',5'-cyclic adenosine monophosphate. | differentiated rat thyroid cells, designated frtl, are totally dependent on tsh for their growth. we continuously cultured frtl cells in the absence of tsh and found that another type of cell appeared in the culture. the new cells were large, flattened and epithelial-like, and none of them exhibited thyroglobulin immunoreactivity. since they grew independently of tsh, we further cloned these mutated cells by the limited dilution method in the absence of tsh. camp production in the cloned cells ( ... | 1990 | 1968381 |
| absence of h-ras point mutation at codon 12 in n-methyl-n-nitrosourea-induced hepatocellular neoplasms in the rat. | in order to assess the possibility that activated ras-associated hepatic carcinomas might be much rarer in rats than mice because of the more frequent or rapid occurrence of powerful carcinogenic event(s) other than ras point mutations in the former animals, precancerous lesions and hepatocellular carcinomas induced by a weak hepatocarcinogen n-methyl-n-nitrosourea (mnu) in the rat liver were analyzed for the presence or absence of ras point mutations. mnu was chosen because it is well known tha ... | 1990 | 1975252 |
| the degree of genetic disparity between donor and host correlates with survival of intraventricular substantia nigra grafts. | we have evaluated the degree of genetic disparity that permits survival of intraventricular brain tissue grafts without additional immunosuppression. fisher 344 rats (n = 100) with unilateral substantia nigra lesions were used as hosts. donors consisted of fischer 344 rats (isografts), sprague-dawley rats (allografts), mice, hamsters, and rabbits (xenografts). grafts were obtained from the ventral mesencephalon of embryonic animals. the functional properties of the grafts were measured by behavi ... | 1990 | 1977465 |
| effect of age and monosodium-l-glutamate (msg) treatment on neurotransmitter content in brain regions from male fischer-344 rats. | peripheral administration of monosodium-l-glutamate (msg) has been found to be neurotoxic in neonatal rats. when administered in an acute, subconvulsive dose (500 mg/kg i.p.), msg altered neurotransmitter content in discrete brain regions of adult (6 month old) and aged (24 month old) male fischer-344 rats. norepinephrine (ne) content was reduced in both the hypothalamus (16%) and cerebellum (11%) of adult rats, but was increased in both the hypothalamus (7%) and cerebellum (14%) of aged rats af ... | 1990 | 1980344 |
| development of lung metastases after curative intraperitoneal chemotherapy in a rat colon cancer model. | a model of colon peritoneal carcinomatosis was developed by injecting 5 x 10(7) viable tumor cells intraperitoneally into fisher 344 rats. all 40 control rats developed bulky abdominal tumor with ascites and died of peritoneal carcinomatosis and bowel obstruction (median survival 5 weeks). one day after tumor implantation, treatment group rats received a single intraperitoneal injection of single agent or combination chemotherapy. the most active intraperitoneal single agents were 5-fluorouracil ... | 1991 | 1990226 |
| acute effects of interleukin-2 on lung mechanics and airway responsiveness in rats. | we studied the acute effects of interleukin-2 (il-2), the principal lymphokine responsible for lymphocyte proliferation, on lung mechanics and airway responsiveness to methacholine (mch) in rats. lewis (n = 12) and fisher 344 (n = 13) rats were anesthetized and intubated, and intravenous and intra-arterial lines were inserted. il-2 (750,000 u/kg) was infused intravenously over 2 to 4 min into seven lewis and seven fisher rats, and vehicle alone was administered to five lewis and six fisher rats. ... | 1991 | 1990957 |
| spinal cord injury: prognosis for ambulation based on sensory examination in patients who are initially motor complete. | the purpose of this retrospective study was to document that patients with motor complete injury, but preserved pin appreciation, in addition to light touch, below the zone of injury have better prognoses with regard to ambulation than patients with only light touch preserved. medical records were examined of all spinal cord injury (sci) patients admitted between 1982 and 1988. twenty-seven frankel b patients with upper motor neuron lesions admitted within 72 hours of injury were identified. the ... | 1991 | 1991012 |
| treatment of anorectal abscess with or without primary fistulectomy. results of a prospective randomized trial. | to determine whether primary fistulectomy should be performed or not at the time of incision and drainage, a prospective, randomized study in 70 patients with anorectal abscess was conducted. thirty-six patients underwent incision, drainage and fistulectomy with primary partial internal spincterectomy (group i), whereas in 34 patients anorectal abscess was treated by incision and drainage alone (group ii). after a median follow-up of 42.5 months, the combined recurrence or persistence rate was 2 ... | 1991 | 1991422 |
| interstitial lung disease: impact of postprocessing in digital storage phosphor imaging. | the ability to resolve the fine linear structures of interstitial lung disease is one measure of the limiting performance characteristics of an imaging system. conventional screen-film radiography was compared with six algorithms of isodose storage phosphor digital radiography (0.2-mm x 10-bit pixel matrix) in the detection of interstitial lung abnormality documented by means of computed tomography in 40 patients with abnormalities and 25 healthy control subjects. performance was evaluated with ... | 1991 | 1994410 |
| experimental intravesical therapy for superficial transitional cell carcinoma in a rat bladder tumor model. | a rodent bladder cancer model that is induced by intravesical instillation of n-methyl-n-nitrosourea (mnu) was characterized. cohorts of four to five week old female fisher 344 rats received four biweekly 1.5 mg. doses of intravesical mnu and were sacrificed at various intervals. by week 13 all animals had flat atypia and/or papillary transitional cell tumors, and 67% of the lesions were moderately (grade ii) or poorly differentiated (grade iii). by week 20, 83% had gross muscle invasive tumors ... | 1991 | 1997724 |
| when genius errs: r.a. fisher and the lung cancer controversy. | r.a. fisher's work on lung cancer and smoking is critically reviewed. the controversy is placed in the context of his career and personality. although fisher made invaluable contributions to the field of statistics, his analysis of the causal association between lung cancer and smoking was flawed by an unwillingness to examine the entire body of data available and prematurely drawn conclusions. his views may also have been influenced by personal and professional conflicts, by his work as a consu ... | 1991 | 2000852 |
| rorschach assessment of psychological functioning in sexually abused girls. | we measured psychological functioning in a group of 79 black females between the ages of 5 and 16 and a comparison group of nonabused girls using the rorschach. in addition to exner's (1985) comprehensive system, the elizur (1949) rorschach content test scale (rct), the mutuality of autonomy scale (moa; urist, 1977; urist & shill, 1982), and the barrier and penetration scales (fisher & cleveland, 1968) were used. sexually abused girls were found to show more disturbed thinking, to experience a h ... | 1991 | 2002437 |
| distribution of chromium within cells of the blood. | although a number of investigators have examined the uptake of chromium in red blood cells (rbc) or whole blood, little is known about chromium uptake in white blood cells (wbc). radiolabeled chromium (51cr) was used to determine chromium uptake and distribution. isolated rbc and enriched wbc populations were exposed in vitro to potassium chromate (cr+6) and uptake was determined over a 2-hr time period. exposure of either rat or human blood cells to 50 microm k2cro4 for 2 hr resulted in greater ... | 1991 | 2006503 |
| age-related effects of chronic ethanol intake on vitamin a status in fisher 344 rats. | the present study was designed to investigate the interaction of age and ethanol on vitamin a status in rats. rats aged 2 and 19 mo were fed a liquid diet containing 36% of total energy as ethanol or pair-fed a diet containing isoenergetic carbohydrate in place of ethanol. after 3 wk older rats had lower serum retinol (p = 0.04) and higher vitamin a concentrations in liver (p = 0.0001), esophagus (p = 0.0001) and the proximal (p = 0.03) and distal (p = 0.0001) colon than younger animals. hepatic ... | 1991 | 2007903 |
| physiologic studies of cerebral ischemia. | using the technology of his day, limited to direct observation and histological techniques, fisher conclusively established the importance of the atherosclerotic carotid plaque in stroke. recognizing the limits of his observations, he raised a number of questions as regards the degree of carotid disease necessary to adversely affect the brain and the effects of silent carotid occlusion. he also suggested the possible beneficial effects of revascularization. these questions have been addressed an ... | 1991 | 2009695 |
| [effects of contrast media products on erythrocyte aggregation. an ex vivo study]. | it has been suggested (fisher and al., rainiko and al.) that contrast media could interfere with a red blood cell aggregation, low-osmolarity and non ionic contrast media leading to red blood cell aggregates in vitro. clinical significance of this phenomenon is not known. we have studied 21 consecutive patients admitted in x ray department for pyelography. sodium and meglumine ioxitalamate (telebrix 38 r; guerbet) osmolarity 2 100 mosm kg--viscosity 8.5 cp at 37 degrees c is used for contrast. r ... | 1991 | 2010708 |
| urinary calcium as an early marker for preeclampsia. | women who develop preeclampsia during pregnancy excrete less calcium than healthy pregnant women. whether this reduction in calcium excretion precedes or follows hypertension is unknown. we prospectively measured urinary calcium excretion in 103 consecutive nulliparous women at risk for preeclampsia and presenting for prenatal care before 24 weeks' gestation. serial 24-hour urine specimens were obtained at 10-24 weeks, 25-32 weeks, and 33 weeks to term. after delivery, the charts were reviewed f ... | 1991 | 2014080 |
| amiodarone- and desethylamiodarone-induced pulmonary phospholipidosis, inhibition of phospholipases in vivo, and alteration of [14c]amiodarone uptake by perfused lung. | amiodarone (am) pulmonary phospholipidosis in patients receiving this drug is well recognized. we investigated the in vivo phospholipidosis-inducing potency of am and its major nonpolar metabolite, desethylamiodarone (dea), in rats, their ability to inhibit phospholipases, and also the effects on pulmonary uptake of [14c] am. fisher-344 male rats (200 to 250 g) were given am or dea (100 mg/kg/d orally) for 2, 7, or 21 d. food consumption and body weight gain were significantly reduced by both am ... | 1991 | 2015101 |
| does the duration of n2o administration affect postoperative nausea and vomiting? | nausea and vomiting are the most frequent postoperative complications in the ambulatory surgical setting. in the present study, data were obtained from 184 adult ambulatory cosmetic surgery patients to determine if the use of nitrous oxide (n2o) was associated with an increased incidence of postoperative nausea and/or vomiting (pnv). anesthesia was induced with thiopental and maintained with an opioid (fentanyl or sufentanil) and isoflurane with or without n2o. data were analyzed statistically u ... | 1991 | 2021655 |
| effect of dietary menhaden, canola and partially hydrogenated soy oil supplemented with vitamin e upon plasma lipids and platelet aggregation. | male fisher rats were fed chow diets for two weeks after which they were divided into seven groups of ten rats each and fed 20% canola, 20% menhaden, 20% partially hydrogenated soy oil (phso) or chow only, with or without 500 mg/kg dietary vitamin e in chow containing 2% cholesterol for six weeks. triglycerides were lower in the menhaden group and were essentially the same in the e supplemented groups as in their unsupplemented cohorts. plasma cholesterol was higher in the canola, and lower in t ... | 1991 | 2028442 |
| effects of perinatal alcohol exposure and dietary calcium supplements on skeletal and dental growth in rats. | osteoporosis, hypocalcemia and skeletal size reduction are all common correlates of perinatal alcohol exposure. the present study assesses the effects of dietary calcium supplements on reversing perinatal alcohol-induced osteopenia. one hundred and twenty-nine offspring from fisher 344 rats received 14% v/v alcohol in tap water from conception to weaning or 3 months of age followed by dietary calcium supplements (230 mg/kg/day) to 6 months of age. significant group effects (p less than 0.001) we ... | 1991 | 2028725 |
| strategies to support the new nurse in practice. | the literature supports the importance of the first job in an individual's chosen profession (andrews, 1987; benner & benner, 1979; huey, 1988). clearly, first job interventions designed to socialize the new graduate nurse into the profession also benefit the employer organization. since the employer organization spends money, time, and energy on orientation but can expect tenure to be short (fisher & connelly, 1989), the use of strategies that increase retention would be desirable both for the ... | 2007 | 2030408 |
| bacillus calmette-guérin immunization in infants born to hiv-1-seropositive mothers. | during the prospective follow-up of 64 babies at risk for perinatal hiv-1 infection because their mothers were seropositive, and of 130 control babies whose mothers were seronegative, we studied the occurrence of complications of bacillus calmette-guérin (bcg) immunization and its ability to induce cutaneous reactivity to tuberculin. babies born both to hiv-1-positive and hiv-1-negative mothers received bcg immunization during their first month of life according to the expanded programme on immu ... | 1991 | 2031692 |
| differential dna-protein crosslinking in lymphocytes and liver following chronic drinking water exposure of rats to potassium chromate. | carcinogenic chromium (vi) compounds are persistent environmental contaminants with potential for human exposure through drinking water. one lesion associated with chromium (vi) exposure is the formation of dna-protein crosslinks (dpc). in an attempt to develop markers of chromium exposure, the formation of dpc in lymphocytes was investigated. fisher 344 rats were exposed to k2cro4 in their drinking water for 3 and 6 weeks at concentrations of 100 and 200 ppm chromium. no dpc could be detected i ... | 1991 | 2038750 |
| central regulation of stress responses: regulation of the autonomic nervous system and visceral function by corticotrophin releasing factor-41. | our understanding of the role of crf in mediating integrated endocrine, autonomic and visceral stress responses is rudimentary at best. delineating the large number of neurochemical factors that influence the activity of crf-containing hypophyseotrophic neurones offers one direction for future research in this area. another approach might be to examine the neuropharmacological actions of transmitters which are co-localized within crf-containing neurones. for example, crf and dynorphin-related pe ... | 1991 | 2039427 |
| expression of p53 mutant protein(s) in diethylnitrosamine-induced foci of enzyme-altered hepatocytes in male fischer-344 rats. | several types of human and animal tumors have been shown to carry mutations in the p53 gene. while the translation product of the wild type gene has tumor suppressor properties, mutant alleles of the gene produce proteins that can cooperate with other oncogene products in transforming cells. in this paper, evidence is presented indicating that a p53 gene mutation(s) occurs in foci of enzyme-altered hepatocytes induced by diethylnitrosamine in male fisher-344 rats. the evidence was obtained by me ... | 1991 | 2044196 |
| increased frequency of infection after open reduction of fractures in patients who are seropositive for human immunodeficiency virus. | in a prospective study of 214 patients who had elective extensive operations for fractures, we compared the relative frequencies of postoperative infections in the seventeen patients who were seropositive for human immunodeficiency virus and had associated clinical symptoms, in the twenty-six patients who were seropositive and had no associated clinical symptoms, and in the 171 patients who were seronegative. the relative frequency of postoperative infection was significantly higher in patients ... | 1991 | 2045392 |
| natural antibodies against bone marrow cells of a concordant xenogeneic species. | hyperacute rejection does not occur when vascularized organs are transplanted between rat and mouse, and this species combination is considered to be concordant. since hyperacute rejection is believed to reflect the presence of pre-existing antibodies (usually of the igm class), and lymphocytotoxic antibodies against rat cells have not been detected in normal mouse sera, it has previously been concluded that mouse anti-rat natural antibody (nab) does not exist. however, studies have not been rep ... | 1991 | 2051029 |
| metabolic responses to swimming exercise in streptococcus pneumoniae infected rats. | the present study was performed to determine whether alterations in fuel reserves or energy substrate utilization might explain the performance decrements that occur in bacterial infections. male fisher-dunning rats were studied at 24, 48, and 72 h after inoculation with streptococcus pneumoniae. rats were either sedentary or subjected to a 2-h swimming session at these three time points (n = 10 in each group). a more than 60% reduction (p less than 0.01) in performance capacity was observed on ... | 1991 | 2056898 |
| the 72-hour examination as a predictor of recovery in motor complete quadriplegia. | twenty-nine c4 to c7 motor-complete spinal cord injured subjects were evaluated to determine whether the manual muscle test (mmt) performed within 24 hours of injury or at 72 hours after injury better predicts short-term functional muscle recovery. a single muscle in the zone of injury that had a muscle grade between 1 and 3, inclusive, was evaluated serially in each patient from admission to three months. increase in muscle strength to grade 4 or better was defined as success. outcomes were eva ... | 1991 | 2059130 |
| renal response to boxing: an investigation of changes in the urine in amateur boxers. | it has been well established that self-limited, benign changes frequently occur in the urine following exercise. this study was undertaken to evaluate potential changes in the urine of amateur boxers. demographic data, a boxing history, a complete medical history, and a physical examination were obtained for each subject. prefight and postfight urine specimens were examined for comparison. the data were subjected to statistical analysis in order to evaluate the significance of mean changes by us ... | 1991 | 2061101 |
| working memory and the aged rat: deficient two-choice win-stay water-escape acquisition and retention. | twelve aged (22 months), 12 adult (12 months) and 12 young (3 months) male fisher 344 rats were compared on acquisition of a two-choice win-stay (spatial delayed matching-to-sample) water-escape working memory task. the 7 aged, 10 adult and 10 young animals that attained criterion were then compared on performance of the task when the retention interval (ri) was 5, 15, 30, 60 and 120 min. they were also compared on retention after being forced to perform an unsolvable water-escape task in a seco ... | 1991 | 2062901 |
| high-dose epinephrine improves the return of spontaneous circulation rates in human victims of cardiac arrest. | to evaluate the return of spontaneous circulation (rsc) rates in human victims of cardiac arrest treated with standard doses of epinephrine (sde) or high-dose epinephrine (hde). | 1991 | 2064091 |
| synthesis and in vivo photodynamic activity of some bacteriochlorin derivatives against bladder tumors in rodents. | bacteriochlorins have been suggested as potential photosensitizers for use in photodynamic therapy. we have shown that bacteriochlorin-like macrocycles can be generated through cyclization of either 5,10- or 5,15-bis[(ethoxycarbonyl)vinyl]porphyrins; however, the resulting products are rapidly decomposed on exposure to air. more stable systems can be generated by diels-alder reactions between dienophiles such as dimethyl acetylenedicarboxylate or tetracyanoethylene, and vinylporphyrinones. altho ... | 1991 | 2066985 |
| immobilization of fishers (martes pennanti) with ketamine hydrochloride and xylazine hydrochloride. | a combination of 100 mg ketamine hydrochloride (kh) and 20 mg xylazine hydrochloride (xh) was used to immobilize fishers (martes pennanti). four adult males were intramuscularly injected a total of five times at dosages between 22.4 to 29.0 mg/kg kh and 4.1 to 6.6 mg/kg xh. mean (+/- se) induction time and arousal time were 3.3 +/- 0.5 min and 76.8 +/- 12.1 min, respectively. respiration, heart rate, and body temperature in response to sedation appeared normal. a 5:1 mixture of kh-xh appears to ... | 1991 | 2067055 |
| effect of mild hyperthermia on the ischemic infarct volume after middle cerebral artery occlusion in the rat. | we investigated the effect of mild whole-body hyperthermia (40 degrees c) on a permanent middle cerebral artery occlusion (mcao) model in fisher rats by subjecting them to mcao under the following conditions: (1) normothermia (n = 20); (2) hyperthermia (n = 14) before (1 hour), during, and after (1 hour) mcao; and (3) post-mcao hyperthermia (n = 14) for 1 hour. we measured brain and body temperatures during the experiment using micro-thermocouples and blood-brain-barrier (bbb) permeability using ... | 1991 | 2067642 |
| photocytotoxicity of anthracyclines upon laser excitation in their long-wavelength absorption bands. | newly synthesized daunomycin derivatives with red-shifted absorption compared to the parent molecule are shown to be able to photosensitize cells in vitro upon excitation with either argon or argon-pumped dye laser. administering 86 j/cm2 total fluence (1 h irradiation) to fisher rat thyroid cells during 2 h incubation with either daunomycin (excitation wavelength: 488 nm) or 5-iminodaunomycin (595 nm) produced cell killing at doses (about 2.7 x 10(-7) m for 50% cell survival) which were not tox ... | 1991 | 2068268 |
| alveolar epithelial cell injuries by subchronic exposure to low concentrations of ozone correlate with cumulative exposure. | electron microscopy morphometry has been used to study the effects of cumulative exposure of low levels of inhaled o3 on lung proximal alveolar tissue. six-week-old fisher 344 rats were exposed to o3 in two different subchronic low-level exposure patterns. the first was a 12 hr/day exposure for 6 weeks and included two o3 concentrations, 0.12 and 0.25 ppm. the second consisted of an exposure profile having a background level of 0.06 ppm with an exposure peak 5 days each week that went from 0.12 ... | 1991 | 2068723 |
| [determination of the activity of extracts of echinaceae and sabal in the treatment of idiopathic megabladder in women]. | 30 patients (25 to 76 years old), suffering from incontinence (18), pollakiuria (6) and dysuria (6) reveal at the urodynamic investigation (urovideo 2100 and neuromatic 2000m) an idiopathic large hypotonic bladder. 20 have been treated by echinaceae (84 to 112 mg/a day) and sabalae (78 to 104 mg/a day) extracts (urgenin: 90 to 120 drops/a day) during a mean time of 77 days. 10 have received 90 to 120 drops/a day of a placebo during a mean time of 52 days. the statistical evaluations have been ca ... | 1990 | 2073038 |
| first person account: a mother's view. | the article that follows is part of the schizophrenia bulletin's ongoing first person accounts series. we hope that mental health professionals--the bulletin's primary audience--will take this opportunity to learn about the issues and difficulties confronted by consumers of mental health care. in addition, we hope that these accounts will give patients and families a better sense of not being alone in confronting the problems that can be anticipated by persons with serious emotional difficulties ... | 1990 | 2077645 |
| [diagnosis of ischemic cardiopathy in ambulatory care patients. multivariate analysis of clinical and electrocardiographic data]. | this study was done on 113 subjects, 93 men and 20 women, whose ages ranged between 32 and 70 years (average 52.9 years). males varied between 35 and 70 years (average 53.7) and females between 32 and 67 years (average 49.5). our objective is: to give an account of the different discriminatory methods with mixed data usually used in medical applications, to apply these methods to all the subjects studied with the purpose of comparing their performance and, to develop a protocol for diagnosing co ... | 2006 | 2077836 |
| enantioselective gas chromatographic assay with electron-capture detection for dl-ritalinic acid in plasma. | enantioselective gas chromatographic assays for the quantitation of methylphenidate and its major metabolite ritalinic acid in plasma are described. the procedures involved the extraction of methylphenidate enantiomers from alkanised plasma. the plasma was then washed to ensure complete removal of methylphenidate before saturation with sodium carbonate to promote the extraction of ritalinic acid enantiomers with ethyl acetate-isopropanol (60:40) solvent mixture. subsequently, ritalinic acid enan ... | 1990 | 2079507 |
| effects of gossypol on the hepatic drug metabolizing system in rats. | gossypol, a polyphenolic pigment found in cotton plants, has been implicated as an antifertility agent. this pigment has been shown to alter myriad metabolic pathways. the objective of this study was to determine the effect of gossypol acetic acid on the hepatic microsomal drug metabolizing enzyme system in adult female fisher 344 rats. subcutaneous administration in both low (15 mg/kg) and high (30 mg/kg) doses of gossypol acetic acid for five consecutive days significantly (p less than 0.00001 ... | 1990 | 2083490 |
| r. a. fisher. twice professor of genetics: london and cambridge or "a fairly well-known geneticist". | 1990 | 2085638 | |
| r.a. fisher's contributions to genetical statistics. | r. a. fisher (1890-1962) was a professor of genetics, and many of his statistical innovations found expression in the development of methodology in statistical genetics. however, whereas his contributions in mathematical statistics are easily identified, in population genetics he shares his preeminence with sewall wright (1889-1988) and j. b. s. haldane (1892-1965). this paper traces some of fisher's major contributions to the foundations of statistical genetics, and his interactions with wright ... | 1990 | 2085639 |
| fisher's contributions to genetics and heredity, with special emphasis on the gregor mendel controversy. | r. a. fisher is widely respected for his contributions to both statistics and genetics. for instance, his 1930 text on the genetical theory of natural selection remains a watershed contribution in that area. fisher's subsequent research led him to study the work of (johann) gregor mendel, the 19th century monk who first developed the basic principles of heredity with experiments on garden peas. in examining mendel's original 1865 article, fisher noted that the conformity between mendel's reporte ... | 1990 | 2085640 |
| eeg cartography before and after visual stimulation: a group study with descriptive non-parametric analysis of eeg data. | ten right-handed students were submitted to a protocol of cognitive visual stimulations based on six successive sequences: ec1, eo, b1, b2, b3, ec2. following a first "eyes closed" (ec1) multiple eeg recording (16 eeg leads, plus polygraphy), and an "eyes-open" recording (eo) with central visual fixation, 60 computer-controlled slides were presented successively for each of three successive recordings (b1, b2, b3) before the last "eyes-closed" recording (ec2). in b1, the subjects were asked to l ... | 1990 | 2094300 |
| multidisciplinary analysis of patients with extratemporal complex partial seizures. i. intertest agreement. | in 15 patients we hypothesized the origin of epilepsies to be 'extratemporal' based on videotaped seizures and surface eeg. neuropsychological tests and neuroimaging (cat, mri, and pet scans) were then compared to the hypothesized ictal sites. neuropsychological tests were abnormal in 86.6% and fdg-pet scans were abnormal in 73%. the neuropsychological tests and pet localized or lateralized areas of dysfunction to the same sites as electroclinical characteristics did in 85% of patients (p less t ... | 1990 | 2105881 |
| production and characterization of monoclonal antibodies against the lethal factor component of bacillus anthracis lethal toxin. | the lethal toxin of bacillus anthracis consists of two components, protective antigen and lethal factor. protective antigen is cleaved after binding to cell receptors, yielding a receptor-bound fragment that binds lethal factor. sixty-one monoclonal antibodies to the lethal factor protein have been characterized for specificity, antibody subtype, and ability to neutralize lethal toxin. three monoclonal antibodies (10g3, 2e7, and 3f6) neutralized lethal toxin in fisher 344 rats. however, in a mac ... | 1990 | 2111283 |
| intrinsic tryptophan fluorescence measurements suggest that polylactosaminyl glycosylation affects the protein conformation of the gelatin-binding domain from human placental fibronectin. | glycosylation can affect the physical and biochemical properties of the polypeptide chain in glycoproteins. asparagine-n-linked polylactosaminyl glycosylation of the chymotryptic 44-kda gelatin-binding domain from human placental fibronectin confers protease resistance [zhu, b. c. r., fisher, s. f., panda, h., calaycay, j., shively, j. e. & laine, r. a. (1984) j. biol. chem. 259, 3962-3970] and weaken the binding to gelatin [zhu, b. c. r. & laine, r. a. (1985) j. biol. chem. 260, 4041-4045]. int ... | 1990 | 2112461 |
| randomized comparative study of cefixime versus cephalexin in acute bacterial exacerbations of chronic bronchitis. | patients with purulent exacerbation of chronic bronchitis were randomized to receive either a single 400-mg daily dose of cefixime or 250 mg of cephalexin, orally, four times a day. patients were males with a mean age of 63 years. of the 86 patients, 71 (82%) had bronchitis caused by a single organism (29 by haemophilus influenzae, 27 by branhamella catarrhalis, 9 by gram-negative enteric organisms, 6 by streptococcus pneumoniae), while more than one pathogen was implicated in 15 patients (18%). ... | 1990 | 2118322 |
| [measurement of gamma-interferon in sera and csf in patients with multiple sclerosis and inflammatory neurological diseases]. | we examined whether gamma-interferon (gamma-ifn) can be detected in serum and csf of patients with multiple sclerosis and other inflammatory neurological diseases. gamma-ifn was assayed by solid phase radioimmunoassay on the forward sandwich principle. in 7 serum samples in acute stage of multiple sclerosis without corticosteroid, in 2 csf samples in acute stage, gamma-ifn was not detected. in stable stage there was no case with positive gamma-ifn. the patient with tuberculous meningitis showed ... | 1990 | 2119268 |
| effect of miso (japanese soybean paste) and nacl on dmba-induced rat mammary tumors. | an ain-76a diet supplemented with miso (japanese soybean paste) reduced the incidence (p = 0.05, fishers exact test) and delayed the appearance (p = 0.04, log rank test) of dimethylbenz[a]anthracene (dmba)-induced mammary adenocarcinomas in female sprague-dawley rats. a nacl-supplemented ain-76a diet (containing the same amount of nacl as in the miso-supplemented diet) also delayed the appearance of tumors (p = 0.02, log rank test) compared with the ain-76a control diet. the miso- and nacl-suppl ... | 1990 | 2120681 |
| [experimental anthrax infection in laboratory animals with differing species susceptibility to the causative agent]. | in guinea pigs and noninbred white mice, infected subcutaneously with anthrax which resulted in their death, characteristic generalized infection with the hematogenic contamination of their organs and the signs of intoxication and shock could be observed. in inbred white rats (fisher 344) the invasion and dissemination of b. anthracis are relatively slightly pronounced, the phenomena of intoxication and shock being clearly prevalent. | 1990 | 2120875 |
| physiological and biochemical indices of neurohypophyseal function in the aging fischer rat. | in order to resolve conflicting reports in the literature on the effect of aging on the hypothalamo neurohypophyseal system (hns) in rats, multiple parameters associated with the hns were evaluated in young (4 months), fully mature (14 months), and old (25 months) fischer 344 rats under basal and stimulated conditions. the hypothalamic hormones oxytocin and vasopressin were compared in radioimmunoassay of serum, urine, brain and pituitary. information on body weight, water intake, urine output, ... | 1990 | 2125706 |
| effect of ageing on adenylate cyclase activity and g-proteins in rat submandibular salivary glands. | membranes were prepared from the submandibular salivary glands of male young (3-months-old) and aged (24-months-old), fisher 344 rats, and assayed for adenylate cyclase activity and for the ribosylation of g-proteins in the presence of [32p]-nad+ and cholera toxin. adenylate cyclase activity (basal, fluoride-, forskolin-, and isoproterenol-stimulated) was significantly lower (p less than 0.01) in the glands of aged rats. the pattern of ribosylation was different between the 2 groups. two cholera ... | 1990 | 2126429 |
| immunocytochemical localization of proteoglycans within normal elastin fibers. | appreciable amounts of glycosaminoglycans have been found by immunocytochemistry within mature elastin fibers of human dermis. on thin sections, elastin fibers showed antigenic sites for monoclonal antibodies recognizing the unsaturated units remaining after digestion of hyaluronic acid with streptomyces hyaluronidase and after digestion of dermatan and chondroitin sulfates with chondroitinase abc. moreover, sectioned elastin fibers were positive towards antibodies raised against synthetic pepti ... | 1990 | 2127920 |
| evaluation of polyvalent anti-pseudomonas aeruginosa vaccine in phagocytic reaction. | in order to obtain immune reaction for all known pseudomonas aeruginosa immunotypes (7 according to fisher), mucoid and nonmucoid variants, rabbits were immunized with polyvalent vaccine consisting of 3 mucoid (1, 3, 5) and 4 nonmucoid (2, 4, 6, 7) immunotypes. the serum of immunized animals induced an increase in normal rabbit granulocyte phagocytosis level as well as intracellular killing of all pseudomonas aeruginosa immunotypes, both mucoid and nonmucoid variants. the serum was also observed ... | 1990 | 2129384 |
| [the miller-fisher syndrome during echo-7 neuro-infection. a case history]. | the authors describe a case of a 36-year old male patient with the miller fisher syndrome of ophthalmoplegia, ataxia and areflexia. an apparent etiopathogenetic factor in this case appears to be echo 7 virus. the pathological process was localized in the brainstem. | 1990 | 2131433 |
| the premorbid personality of patients with different subtypes of an affective illness. statistical analysis of blind assignment of case history data to clinical diagnoses. | on the basis of case history data, the assumption that there exists an association between the 'manic type' of personality and a predominantly manic course of an affective illness, and between the 'melancholic type' of personality and a unipolar depressive course of the illness was examined. premorbid data were extracted from 42 case records, 10 of 'unipolar' manic subjects (the ratio of manic to depressive episodes greater than or equal to 4:1), 11 of typical bipolar i patients, 11 of bipolar i ... | 1958 | 2136868 |
| allergic contact dermatitis to ethylenediamine. a continuing problem. | ethylenediamine would be an infrequent sensitizer if it were not present in a widely prescribed topical corticosteroid preparation that is applied to inflamed skin. occupational allergic contact dermatitis to ethylenediamine is not common. the educational efforts of american dermatologists such as dr. alex fisher have helped lead to the deletion of ethylenediamine from mycolog cream. it is unfortunate that the same pharmaceutical company continues to use ethylenediamine in its products in other ... | 1962 | 2137392 |