Publications
| Title | Abstract | Year Filter | PMID(sorted ascending) Filter |
|---|
| the usefulness of measles haemagglutination inhibition test in detecting rinderpest antibodies in cattle and sheep after inoculation of tissue culture rinderpest vaccine. | 1979 | 536029 | |
| [subacute sclerosing panencephalitis. a case with a prolonged course in an adult. isolation and characteristics of a "defective" measles virus (author's transl)]. | a 33-year-old man had a 6-year history of clinical signs suggesting multiple sclerosis : visual lesion at 27 years of age, cerebellar and visual disturbances at 31, which partly regressed, lymphocytosis and increased-gammaglobulin levels in the cerebrospinal fluid. biological and anatomical (optical and ultrastructural) examinations gave results typical of a subacute sclerosing panencephalitis. a cytopathogenic measles virus was isolated from a cerebral biopsy specimen. the agent was transmissab ... | 1979 | 538383 |
| subacute sclerosing panencephalitis in chandigarh. | 1979 | 541000 | |
| detection of igg antibody to measles virus by radioimmunoassay technique. | a highly sensitive procedure of solid-phase radioimmunoassay (ria) was developed for the detection of measles igg antibody. hela cells persistently infected with measles virus were used as a solid-phase antigen. this technique was applied to the detection of measles igg antibody in patients with subacute sclerosing panencephalitis (sspe) and multiple sclerosis. normal subjects having experienced natural measles or measles vaccination and patients with various neurological diseases of non-virus n ... | 1979 | 541873 |
| the accelerated storage test applied in the study of thermal stability of haemagglutinating measles virus antigen. | 1979 | 546374 | |
| [multiple sclerosis: immunological aspects in relation with the measles virus]. | 1979 | 550223 | |
| [the actual aspects of measles vaccinations (author's transl)]. | following a brief introduction to measles epidemiological aspects and complications, the authors expound on the essential characteristics of various types of vaccinations. they then synthesize the effects, indications, contraindications and duration of the immunization in relation to measles vaccinations. | 1979 | 554554 |
| the present prophylactic trends of rubella and measles. | starting from the epidemiological investigation on a sample of 22.560 subjects of different chronological age classes in the latium region with the research of hemoagglutinoinhibiting antibodies of the rubella virus, and of 9.800 subjects with the research of hemoagglutinoinhibiting antibodies of the measles virus, the authors observe that the diffusion of the seroprotection presents on an average 82.5% for rubella and 79.8% for measles. on the strength of the results, referred also according to ... | 1979 | 555675 |
| antibodies against latent neurotropic viruses in serum and cerebrospinal fluid samples from patients with multiple sclerosis. | 1979 | 556120 | |
| persistent measles virus infection in a calf kidney cell line. note i. establishment of calf kidney cell lines chronically infected with measles virus and some of their biological characteristics. | several types of persistent measles virus infection resulting in lytic infections could be established in a calf kidney cell line, according to the passage level of the substrate and to the virus strain inoculated. persistent measles virus infection in calf kidney cells was characterized by the limited proportion of infected cells, the large amount of infectant virus, and the alteration of morphological and growth characteristics of the cells. the mechanism of this persistent infection is discus ... | 1977 | 559370 |
| immunofluorescence study of brain plaques from two patients with multiple sclerosis. | immunofluorescence studies were performed on selected plaques from two multiple sclerosis patients. positive staining revealed the corresponding presence of immunoglobulin g and complement fraction c1q within the plaque areas. these components could be removed only after low ph washing. on the basis of these observations, we discuss the possibility of the presence of immunocomplexes within the multiple sclerosis brain. | 1977 | 559966 |
| [isolation of a measles-like agent from the brain of the autopsy specimen of subacute sclerosing panencephalitis (sspe). clinical manifestations and immunological and virological evaluations]. | 1977 | 560272 | |
| negative seroconversion and circulating interferon in children vaccinated with live measles vaccine. | in none of the examined children, regardless of whether they manifested negative (17 children) or positive (25 children) seroconversion after vaccination with live measles vaccine, interferon activity could be demonstrated in the serum (starting with 1:4 dilution) withdrawn at the time of the vaccine administration. | 1977 | 562373 |
| measles virus mutants and their implications in basic and applied virology. | 1977 | 565182 | |
| ["late onset disease" (congenital german measles) (author's transl)]. | the paper reports on a case of "late onset disease" (congenital german measles). diagnostically significant for this disease in an infant appearing perfectly healthy when new-born, were mainly the findings of an interstitial pneumonia, hepatosplenomegaly, as well as findings indicating the presence of a meningoencephalitis and retinopathy. the diagnosis of this rare course of congenital german measles was finally established via the identification of specific igm rubeola antibodies, of a raised ... | 1978 | 565431 |
| measles antibodies and hla. | 1978 | 566295 | |
| cell-mediated immunity to measles, myelin basic protein, and central nervous system extract in multiple sclerosis. a longitudinal study employing direct buffy coat migration inhibition assays. | cell-mediated immunity to myelin basic protein, to an extract of central nervous system white matter, and to measles virus nuclear core, was studied nine patients with multiple sclerosis in a serial longitudinal fashion using in vitro inhibition of buffy coat migration. the mean migration index to all antigens at various times before, during, and after exacerbation of multiple scelrosis in the patients did not differ from the index in a reference group of normal subjects. the incidence of inhibi ... | 1978 | 567297 |
| the occurrence, specificity, and role of neuroelectric blocking factors in multiple sclerosis. | 1978 | 568750 | |
| notes on the pathogenesis of multiple sclerosis. | 1978 | 568754 | |
| [age of measles vaccination in lombardy from the results of a seroepidemiological survey in milan]. | in view of the introduction of measles vaccination in lombardy and since the age of vaccination is of paramount importance, measles h.i.a. were titrated in sera from 209 children between 0 and 6 years of age (of whom 171/0--2) and from 40 woman in the child-bearing age. as it could be expected from the high prevalence of adults with antibody (95%), 90% of umbelical cord sera have h.ia.,, over 50% of children 15 days-3 months of age are still positive and afterwards the positivity decreases progr ... | 1978 | 570046 |
| increased csf igm in multiple sclerosis. | csf igm levels have been measured by radioimmunoassay in 56 patients with ms, 62 patients with other neurologic diseases, and 31 normal controls. forty-eight percent of the patients with ms had a raised csf igm level compared with 5 percent of the patients with other diseases. the igm level did not correlate with the igg level. forty percent of the ms patients with normal igg levels had high igm levels. no relationship was found between the csf igm level and length or severity of the ms, relapse ... | 1978 | 570665 |
| lymphocyte adherence in multiple sclerosis. | it has been reported that peripheral blood lymphocytes from patients with multiple sclerosis (ms) adhere to measles-infected human epithelial cells in significantly greater numbers than do lymphocytes from healthy volunteers or patients with other neurologic diseases. we have confirmed this observation in three separate studies, and have investigated the relationship of lymphocyte adherence to the clinical state. lymphocyte adherence determination values correlated with the degree of certainty o ... | 1979 | 571067 |
| [specific cytolytic activity of human lymphocytes following vaccination with vaccinia virus and measles virus]. | human peripheral lymphocytes harvested 7 days after vaccination with vaccinia virus or measles virus lyse specifically target cells infected with the corresponding virus. this cytotoxic activity is found in a subpopulation of lymphocytes depleted of t-cells and containing lymphocytes bearing fc receptor. the activity can also be transferred by supernatant of immune lymphocytes on addition of normal lymphocyte. these results suggest that two types of cell are involved: an antibody-secreting cell ... | 1978 | 571140 |
| adherence of human peripheral blood lymphocytes to measles-virus infected cells: modulation by solubilized rhesus erythrocyte membranes and carbohydrates. | the adherence of human peripheral blood lymphocytes to hela cells persistently infected with measles virus (hela-k11) was studied. the following data were observed. (i) the proportion of hela-k11 cells with adherent human peripheral blood lymphocytes of rhesus monkey erythrocytes was similar over a wide range of ratios of hela-k11 cells to lymphocytes or erythrocytes. (ii) the great majority of human peripheral blood lymphocytes and erythrocytes reacted with the same hela-k11 cell (iii). the adh ... | 1979 | 572346 |
| evaluation of the eight-year period of compulsory measles vaccination in the czech socialist republic (csr). | the object of the study is the evaluation of a more than 8-year period of compulsory vaccination against measles in the csr. so far, a total of 1,850,000 children have been vaccinated. a pronounced decrease has been achieved in morbidity while mortality and lethality reached zero values as early as in 1973. changes occur in the epidemiological characteristic of measles manifested primarily by the shift of the age distribution of notified cases into older age groups, by continuous prolongation of ... | 1979 | 575149 |
| persistent measles virus infection in a calf kidney cell line. note iii. cellular alterations in the selected chronically infected k-2 cell line. | marked morphological, growth and chromosome alterations pointing to in vitro cellular transformation were made evident in a selected calf kidney cell line (k-2) chronically infected with measles virus. the transformed cell line released infectant virus and had no oncogenic potential for the hamster. | 1979 | 575453 |
| measles immunization. successes and failures. | as a result of a large outbreak of measles, measles hemagglutination inhibition (hi) titers were measured in 465 immunized children. titers of less than 1:4 were found in 14.6% of children immunized at 12 months of age as compared to 5.2% of those immunized at 13 months of age or later. measles antibody titers were higher in the mothers of seronegative children who had been immunized at 11 or 12 months of age than in the mothers of seroposotive children. measles hi titers of 1:4 or more were pre ... | 1977 | 576165 |
| measles immunization: new recommendation. | 1977 | 576171 | |
| failure of attenuated viral vaccine in prevention of atypical measles. | 1977 | 579203 | |
| [comparison between productive and latent infection by measles virus in subacute panencephalitis]. | 1977 | 588779 | |
| lymphocyte stimulation in multiple sclerosis patients untreated and treated with transfer factor. long-term studies on the effect of different stimulants on myo-(2-3h)inositol incorporation into phosphatidylinositol of lymphocytes. | the lymphocytes from controls, untreated ms and ms patients treated with transfer factor were stimulated with pha, pwm, ppd, lps and ma and the increased incorporation of myoinositol into phosphatidylinositides was determined. as compared with controls, the untreated ms patients revealed significantly lower index of stimulation with pha, lps, ppd and ma. the response of lymphocytes from ms patients treated with transfer factor was intermediate. no correlation between disease progression and stim ... | 1977 | 605771 |
| the effect of the dna-suppressing factor (dsf) on host dna synthesis in synchronized cell cultures. | purified host dna-suppressing factor (dsf) produced into culture fluid of hela c-9 cells infected with measles virus inhibited cellular dna synthesis in hela cells. when purified dsf was added into cultures of synchronous hela cells at the early g1-phase, cellular dna synthesis was irreversibly inhibited. however, dsf did not affect the stability of native double-stranded dna nor the chain-elongation of single-stranded dna in cells of the s-phase. | 1977 | 607094 |
| subacute sclerosing panencephalitis: paramyxovirus-like nucleocapsid observed in brain homogenate. | 1977 | 609029 | |
| agents affecting health of mother and child in a rural area of kenya. iii. the epidemiology of measles. | between april 1974 and march 1976 surveillance of measles has been conducted by 12 fieldworkers making fortnightly home visits among a total population of 24,000 living in nearly 4000 households scattered in variable density throughout an area of 87 sq km in the northern division of the machakos district, kenya. the diagnosis of measles was verified by one of the project's physicians according to standardized procedures and was, whenever possible, supported by virus isolation and serum antibody ... | 1977 | 610029 |
| [vaccination against measles]. | 1977 | 610938 | |
| multiple sclerosis and malabsorption. | malabsorption tests were studied in 52 patients with multiple sclerosis. the stools were examined microscopically for fat and undigested meat fibers and were found to be abnormal in 41.6 and 40.9% respectively. abnormally low five hour excretion of d-xylose was demonstrated in 26.6% cases. malabsorption of vitamin b12 was found in 11.9% cases. the jejunal mucosa was examined histologically and by tissue immune technic including viral studies. histology showed normal mucosa in all except seven pa ... | 1977 | 612212 |
| is multiple sclerosis an age-dependent host response to measles? | a hypothesis is presented that multiple sclerosis (ms) may represent an unusual host response to measles virus, dependent upon when the measles virus is acquired. if acquired late in childhood or near adolescence, the risk of ms is increased. evidence to support this hypothesis is still meager, but there is ample support from many types of infection for the idea that a host's response may vary with age at the time of infection. as measles virus titers are somewhat increased in ms, evidence for a ... | 1977 | 616540 |
| virological and immunological studies in experimental sspe. | subacute sclerosing panencephalitis (sspe) is a progressive, fatal inclusion cell encephalitis of children and adolescents caused by persistent measles virus within the central nervous system (cns). because studies in man have failed to elucidate the pathogenesis of this condition, animal studies are necessary. persistent infection of the hamster cns can be achieved with a hamster adapted sspe agent. animals inoculated intracerebrally with this virus raise antibodies to all known antigens of mea ... | 1977 | 616550 |
| immunological response of subacute sclerosing panencephalitis patients to measles virus. | the immunological responses of patients with clinical signs of sspe were examined by the direct migration inhibition, complement-mediated antibody cytoxicity and the lymphocyte-mediated cytotoxicity assay techniques. peripheral lymphocytes migrated similarly to controls when exposed to measles antigen. lymphocytes from sspe patients responded to a sspe strain of measles infected cells in a manner similar to lymphocytes from controls. a factor which interfered with the expected activity of sensit ... | 1977 | 616551 |
| immunologic injury in measles virus infection. iv. antigens modulation and abrogation oflymphocyte lysis of virus-infected cells. | 1978 | 618410 | |
| the relationship between direct migration inhibition with measles antigen and e rosettes in normals and patients with multiple sclerosis. | 1978 | 618411 | |
| [formation of dna-proviruses in cells of a human transplantable lymphoid line during infection with tick-borne encephalitis viruses or measles virus]. | 1978 | 620634 | |
| intracellular synthesis of measles virus-specified polypeptides. | the intracellular synthesis of measles-specified polypeptides was examined by means of polyacrylamide gel electrophoresis of cell extracts. since measles virus does not efficiently shut off host-cell protein synthesis, high multiplicities of infection were used to enable viral polypeptides to be detected against the high background of cellular protein synthesis. the cytoplasm of infected cells contained viral structural polypeptides with estimated molecular weights of 200,000, 80,000, 70,000, 60 ... | 1978 | 621777 |
| radioimmunoassay of measles virus antigen and antibody in sspe brain tissue. | 1978 | 622392 | |
| measles virus vaccine should not be used in pups. | 1978 | 624660 | |
| glycoproteins of measles virus under reducing and nonreducing conditions. | measles virus has two glycoproteins. the larger glycoprotein (ha) is composed of 76,000-dalton subunits that are bound by disulfide bonds. the smaller glycoprotein (f) appears to contain a glucosamine-rich portion that is linked to an unglycosylated protein by disulfide bonds. | 1978 | 625090 |
| immunosuppressive measles encephalopathy. | a case of measles infection without a rash, which was followed by a severe encephalopathy after two months, is described in a 2 1/2 year old boy. at the age of 8 months he had been irradiated for an inoperable intrathoracic neuroblastoma, and at the time of exposure to measles he was being treated with cyclophosphamide and vincristine. this case closely resembles other cases recently described and termed immunosuppressive measles encephalopathy. the syndrome is believed to represent the effect o ... | 1978 | 626062 |
| evidence for reinstatement of infants 12 to 14 months of age into routine measles immunization programs. | the hemagglutination inhibition (hi) serologic responses of 851 measles-susceptible infants and children to the live, further-attenuated measles virus vaccine were evaluated over a ten-year period. the response by age at 23-day intervals was determined. infants inoculated at 12 through 14 months of age demonstrated seroconversion rates by hi assay comparable to those in infants and children inoculated at 15 months of age or older. this finding does not support the recent recommendation that rout ... | 1978 | 626182 |
| measles revaccination. persistence and degree of antibody titer by type of immune response. | during a measles immunization campaign 203 children were enrolled in an antibody response study. of this group, follow-up clinical data and sera samples were available from 125 children three weeks after immunization and from 90 children ten months later. seventy-six of the children had been previously vaccinated, ten had a history of measles and 39 denied vaccination or illness. twenty-six of the children had prevaccination hemagglutination inhibiting antibody titers of less than 5. of this gro ... | 1978 | 629246 |
| human colostral macrophages as indicator cells in migration inhibition test. | the macrophage inhibition test was carried out using colostral macrophages obtained from ppd sensitive and measles and mycoplasma pneumoniae antigen insensitive woman. the macrophage migration was inhibited by ppd but neither by measles nor by mycoplasma pneumoniae antigen. human colostral macrophages can be used as indicator cells in migration inhibition tests. | 1978 | 631918 |
| immunoglobulin class distribution of measles virus antibodies in serum and spinal fluids of patients with subacute sclerosing panencephalitis. | sera and cerebrospinal fluids (csf) from patients with subacute sclerosing panencephalitis (sspe) were tested by indirect immunofluorescence for the presence of measles virus specific antibodies of the various heavy chain classes. igg and iga antibodies were detected in the csf while igg, igm, iga, igd and ige measles virus antibodies were found in a significant number of the patient sera. sera from sspe patients had slightly elevated levels of igg, igm, igd and ige while iga was decreased. the ... | 1978 | 631919 |
| differences between the intracellular polypeptides of measles and subacute sclerosing panencephalitis virus. | 1978 | 634370 | |
| membrane proteins of subacute sclerosing panencephalitis and measles viruses. | 1978 | 634371 | |
| significance of some immunochemical data for the viral pathogeny of multiple sclerosis. | cerebrospinal fluid (csf) samples from 124 patients with different neurological diseases (35 having an ascertained diagnosis of multiple sclerosis (ms) and 20--of subacute sclerosing panencephalitis (sspe)) were investigated by immunoelectrophoresis. the correlation between the "secretory" immunoelectrophoretic pattern of csf proteins in ms and sspe patients and the incidence of antimeasles hi antibodies in the csf is analysed. the results point to a different pathogenic significance of the pres ... | 1978 | 636308 |
| antimeasles serum antibodies in multiple sclerosis patients as compared with their relatives and cose contacts. | 1978 | 636312 | |
| immunoglobulins and viral antibodies in psychiatric patients. | the serum and csf of 66 patients with functional psychoses were tested for immunoglobulins and antibodies to measles, hsv-i, cmv, and rubella viruses. ten surgical and 80 neurological patients were controls. there were no significant findings in the serum, consistent with most previous studied. in the csf 6 of 17 multiple admission schizophrenic patients had definite elevations of igg or measles antibody and differed significantly from the surgical controls. immunologically this group resembled ... | 1978 | 638387 |
| establishment and characterization of a subacute sclerosing panencephalitis (measles) virus persistent infection in bgm cells. | infection of bgm cells with the halle isolate of subacute sclerosing panencephalitis (sspe) gave rise to a persistent infection (bgm/halle), whereas infection of another african green monkey kidney cell line (vero) under identical conditions led to a lytic infection. the bgm/halle cells multiplied more slowly than the non-infected cells (even when the medium was changed daily). under such conditions 10(7) to 10(8) p.f.u./ml/24 h of measles virus was released into the medium. it was established t ... | 1978 | 641529 |
| characterization of an rna-dependent rna polymerase activity associated with measles virus. | an rna-dependent rna polymerase activity has been found copurifying with measles virus infectivity and complement-fixing antigen in three vero cell-grown variants of measles virus: the attenuated edmonston b strain, the natural non-attenuated edmonston strain, and a subacute sclerosing panencephalitis isolate, ip-3. incubation of purified measles virions with immunoglobulin g derived from sera of monkeys hyperimmunized against measles specifically removes activity sedimenting in the density regi ... | 1978 | 642073 |
| structural polypeptides of measles virus. | the structural polypeptides of two strains of measles virus grown in vero cells were analysed in sds-page slab gels. six major polypeptides were identified with mol. wt. of 79000, 72000, 60000, 43000, 40000 and 36000. the largest polypeptide was sensitive to trypsin digestion and was the dominant glycosylated polypeptide identified when the virus was grown in medium containing 3h-fucose or 3h-glucosamine or when the virus was treated with galactose oxidase and labelled with 3h-sodium borohydride ... | 1978 | 650174 |
| n-acetylneuraminic acid (nana) in measles virus. | 1978 | 652801 | |
| studies on the mechanism of measles virus-induced suppression of lymphocyte functions in vitro: lack of a role for interferon and monocytes. | 1978 | 657287 | |
| measles virus out as possible cause of ms. | 1978 | 660797 | |
| measles virus polypeptides synthesis in infected cells. | 1978 | 664228 | |
| [associated action of the measles and mumps viruses on the lymphatic apparatus of guinea pigs]. | the immunomorphological and cytopathological properties of vaccine strains of measles and epidemic mumps viruses inoculated individually and together were studied in experiments in guinea pigs. the optimal doses of measles and mumps monovaccines were found to produce morphological changes of similar intensity in the lymphatic apparatus of guinea pigs. measles virus stimulated increased alterative changes in lymphoid elements with increased inoculations; mumps virus produced maximum degeneration ... | 1978 | 664623 |
| a biological perspective of slow virus infection and chronic disease. | sequential events characterize the interaction of viruses with parenchymal cells, and acute lytic infections of tissues and organs have broad biological attributes. a knowledge of these permits a keener understanding of persistent, intermittent herpesvirus infections and persistent, continuous respiratory virus infections. in addition to unique biochemical mechanisms which may permit the latter chronic infections to evolve, the roles of defective and mutant strains of virus, viral interference, ... | 1978 | 664641 |
| the sero-epidemiology of measles in rwanda. | 1978 | 665238 | |
| the preparation of latex particles with covalently bound polyamines, igg and measles agglutinins and their use in visual agglutination tests. | carboxylated latex particles were substituted with side arms terminating in primary amine and hydrazine groups. the particles were coupled to aldehyde groups generated on glycoproteins which were treated with sodium periodate. particles having the alipathic primary amine putrescine hapten as the sole substituent and particles linked to glycoproteins such as measles agglutinins and igg were used to detect the presence of the corresponding antibodies or antigens in biological fluids by agglutinati ... | 1978 | 670724 |
| complement-dependent cytotoxicity of sera obtained from subacute sclerosing panencephalitis patients. | human lymphoid cells (nc-37) persistently infected with either measles virus (schwarz and tycsa strains) or subacute sclerosing panencephalitis (sspe) virus (halle and mantooth strains) were destroyed in the presence of complement by anti-measles sera as well as by sera from sspe patients. the cytotoxic activity was demonstrated in both igg and igm fractions of measles convalescent sera, but only in igg fraction of sspe sera. measles convalescent sera completely lost the cytotoxic activity to al ... | 1978 | 672673 |
| persistent measles virus infection in a calf kidney cell line. note ii. study of some biological markers of the measles virus isolated from a selected chronically infected cell line. | the biological characteristics of a measles virus strain (co-69/pi) isolated from a selected chronically infected calf kidney cell line (k-2) are studied in comparison with those of thw wild parental co-69 and of the attenuated schwarz measles virus strain. co-69/pi is a variant of the parental co-69 virus and has characteristics of an attenuated strain. some of the characteristics acquired by the co-69/pi strain (cytopathogenicity, size of plaques) proved to be stable in the course of passages ... | 1978 | 676071 |
| pulmonary nodular "pneumonia" during the acute atypical measles illness. | 1978 | 677746 | |
| [a 3d type of measles encephalitis?]. | 1978 | 678026 | |
| lymphocyte-mediated cytotoxicity to cells infected with measles virus. i. use of in vitro infected leukocytes as autologous target cells; absence of virus-specific cytotoxic lymphocytes. | 1978 | 679280 | |
| paramyxovirdae. | iit is proposed that the family paramyxovirdae shall comprise three genera: paramyxovirus, morbillivirus, and pneumovirus. | 1978 | 681143 |
| cell-mediated cytotoxicity against virus-infected target cells in humans. i. characterization of the effector lymphocyte. | in a 51chromium release assay performed without immune sera, purified lymphocytes from randomly selected healthy donors killed significantly more allogeneic virus-infected than noninfected fibroblasts. an incubation period of 18 to 20 hr was optimal for determining cytotoxicity, but increased cytotoxic activity against infected cells was observed as early as 6 hr from the start of the test. no correlation could be found between donors' antibody titers to any virus tested and the cytotoxic effici ... | 1978 | 681748 |
| separate pathways of c activation by measles virus cytotoxic antibodies: subclass analysis and capacity of f(ab) molecules to activate c via the alternative pathway. | 1978 | 690438 | |
| a semi-continuous system for the production of human interferon in lymphoblastoid cell cultures. | the simultaneous occurrence of virus replication and of interferon production in namalva lymphoblastoid cell cultures infected with measles virus has allowed the development of a semi-continuous production system yielding about 10(4) units of interferon for each 10(6) cells. | 1978 | 690609 |
| severe demyelinating diseases in childhood: a clinicopathological study. | case reports of six children seen by the author were selected to emphasize that severe demyelinating diseases occur in childhood, even if rarely. cases include measles encephalitis, acute and chronic, subacute sclerosing panencephalitis, neuromyelitis optica, and multiple sclerosis, confirmed by pathologic findings, and, finally, a case of multiple sclerosis in a living child. emphasis is directed to the clinical and pathological findings of demyelinating diseases associated with viral encephali ... | 1978 | 691079 |
| [state of measles immunity in mulitple sclerosis]. | 1978 | 695518 | |
| immunogenicity of uv-inactivated measles virus. | by means of the antigen extinction limit test it was shown that a triple dose vaccination of guinea pigs with uv-inactivated measles virus gave better results, than a single dose vaccination which was proved by the very low immunogenicity index. for both vaccination schemes (single and triple) the immune response was only slightly influenced by a change of dose from 10(5) to 10(6) hadu50/ml or by the addition of aluminum adjuvant. in the antigen extinction limit test the antibody levels were det ... | 1978 | 696055 |
| comparison of wild-type and subacute sclerosing panencephalitis strains of measles virus. neurovirulence in ferrets and biological properties in cell cultures. | the neurovirulence of two wild type (wt) and seven subacute sclerosing panencephalitis (sspe) measles virus strains was tested in young adult ferrets by intracerebral (ic) inoculation of infected vero cell suspensions. wt strains edmonston and woodfolk and sspe strains mantooth, halle, and lec-s did not produce a detectable encephalitis in the ferrets, but caused a significant formation of serum antibodies against measles virus. sspe strains lec, ip-3, biken, and d.r., on the other hand, were al ... | 1978 | 702052 |
| activation of measles virus from silently infected human lymphocytes. | lymphocytes were incubated with measles virus for 4 days in the absence of a lymphocyte stimulating agent. such nonstimulated lymphocytes, infected with measles virus, did not express the virus antigens that are detectable by cytotoxic antibodies. approximately 1 out of 5,000, or even fewer, of such lymphocytes produced virus as demonstrated by the infectious center assay; in the supernate only 10--100 infectious viruses per milliliter were detected. no virus structures could be observed by mean ... | 1978 | 702064 |
| solid-phase radioimmunoassay determination of virus-specific igm antibody levels in a follow-up patients with naturally acquired measles infections. | the question of the exact disappearance time or possible persistence of measles-specific igm antibodies after naturally acquired measles virus infections was studied with a sensitive solid-phase radioimmunoassay (ria) method. a total of 30 patients were analyzed with follow-up times varying from 4.5 to 8 months; all were measles igm positive in the first serum specimen obtained after the onset of rash. in 29 of 30 patients, the measles igm declined to undetectable levels by approximately 90 days ... | 1978 | 702117 |
| analysis of immunoprecipitated surface glycoproteins in measles virions and in membranes of infected cells. | measles viral envelope proteins were immune precipitated from membranes of infected cells and from purified virus and analyzed by polyacrylamide gel electrophoresis. under reducing conditions, specific precipitates contained two major polypeptide bands, designated virus glycopeptides 1 and 2 (vgp-1 and vgp-2). both polypeptides appeared to be glycosylated, as indicated by their incorporation of [(14)c]glucosamine in infected cells. vgp-2 appeared as a single band in specific precipitates of infe ... | 1978 | 702652 |
| absence of measles proviral dna in systemic lupus erythematosus. | 1978 | 703833 | |
| viral antibodies in multiple sclerosis. | 1978 | 704893 | |
| susceptibility of mice to acute and persistent measles infection. | intracerebral inoculation of neonatal mice with the edmonston strain of measles virus produced an acute, lethal encephalitis and thymic dysplasia in susceptible mice. there was an age-related development of resistance to infection. this resistance was strain-dependent and appeared to be associated with the extent of virus growth in the brain. studies on the genetic basis for susceptibility, using hybrid and backcross mice, revealed that the principal determinant of host resistance to acute infec ... | 1978 | 711331 |
| a ten-year follow-up study on measles vaccination in japan: evaluation of the efficacy analyzed on a computer system. | a long-term surveillance system using a computer system was established for the follow-up study on the protective effect of measles vaccination. more than 3,000 children, 3 to 6 years of age, who were immunized with measles vaccines by various methods have been registered in the system since 1971, and their outcomes with regard to measles have been followed up every year. the subjects were divided into three groups by the vaccination method: live vaccine alone (l), further attenuated live vaccin ... | 1978 | 713161 |
| electron microscopic study of measles virus infection: cell fusion and hemadsorption. | virus-induced cell fusion has been studied after infection of vero cells with measles virus. scanning and transmission electron microscopy were combined with immunoperoxidase labeling of measles antigens to correlate viral production and distribution of virus-induced erythrocyte binding sites with progress of fusion. release of infectious virus started before syncytia were detected and decreased while the number and size of syncytia were increasing. most virions were seen budding from mononuclea ... | 1978 | 722861 |
| the use of a measles latex reagent for the determination of measles antibodies and in a specific test for multiple sclerosis. | measles virus antigens covalently linked to latex spheres were used for measuring measles-specific antibodies in a direct agglutination test either in microtitre plates or as a rapid slide-agglutination test. the titres were compared to that obtained by conventional assays. the measles-latex spheres were also used as the antigen for a radio-immuno assay. by incorporating a 14c-radioactive marker into the measles-latex spheres their interaction with lymphocytes from multiple sclerosis and control ... | 1978 | 723785 |
| generation of virus-specific cytolytic activity in human peripheral lymphocytes after vaccination with vaccinia virus and measles virus. | human peripheral blood lymphocytes (pbl) harvested after vaccination with vaccinia or measles virus showed a specific activity against virus-infected target cells. this activity peaked on day 7 and was specific for the target cells infected with the virus used for the vaccination. the cytotoxic activity was not related to hla markers. the cells involved in the cytolytic process were lymphocytes bearing fc receptors. in addition, the cytotoxic activity was abrogated by more than 90% by rabbit fab ... | 1978 | 723792 |
| subacute sclerosing panencephalitis. | subacute sclerosing panencephalitis (sspe) is now considered to be caused by measles virus. there are four diagnostic criteria, namely the clinical picture, a characteristic eeg, serology of serum and csf and brain histology. a register of cases in the u.k. has been kept since 1971, and up to september 1977, ninety-six patients have been reported. the male/female ratio is 2 : 1. the disease most commonly affects children between the ages of nine and eleven years who usually have had measles at a ... | 1978 | 724581 |
| measles virus polypeptides in purified virions and in infected cells. | a wild-type measles virus was radiolabeled during growth in vero cells and purified by two successive potassium tartrate gradient centrifugations. the virion polypeptide composition was determined by sds-polyacrylamide gel electrophoresis employing two different buffer systems. six virus-specific polypeptides were consistently detected. the largest (l) had a molecular weight (mw) of greater than 150,000. the second largest polypeptide, g (mw 79,000), was the only glycoprotein found. the proteins ... | 1978 | 726895 |
| immunological events in acute measles influencing outcome. | 77% of 30 children with measles who had severe lymphopenia (less than 2000/mm3; less than 2.0 x 10(9)/1) within 2 days of appearance of rash (group a) subsequently died or progressed to chronic chest disease. this was significantly worse than the outcome in 30 children with measles who had lymphocyte counts more than 2000/mm3 (more than 2.0 x 10(9)/1) (group b) of whom 67% recovered. in group a children the persistence of severe lymphopenia (caused by a reduction in t- and b-cells) for at least ... | 1978 | 727809 |
| subacute encephalitis and hydrocephalus in hamsters caused by measles virus from persistently infected cell cultures. | newborn hamsters were inoculated intracerebrally with measles virus materials from lu 106 and vero carrier cell lines. extracellular and cell-associated materials from cultures incubated at 37 degrees c and at 33 degrees c were used. the lower temperature allows accentuated virus replication. no animals contracted acute encephalitis, but 8 animals developed advanced neurological disease (unsteady gait, serial myoclonic jerks, hypoactivity) 79 to 212 days after injection. seven out of these 8 ani ... | 1978 | 731212 |
| cns disease following dissemination of sspe measles virus from intraperitoneal inoculation of suckling hamsters. | acute encephalitis was observed in suckling golden syrian hamsters following intraperitoneal (ip) inoculation of a hamster brain adapted strain of subacute sclerosing panencephalitis (sspe) measles virus (hbs). virus was isolated from the brains of all encephalitic animals by cocultivation of tissue with vero cells. the histopathology of the encephalitis was characterized by perivascular mononuclear infiltrates, necrosis, eosinophilic inclusion bodies, and rare giant cells. association of enceph ... | 1978 | 731213 |
| [an atypical case of subacute sclerosing panencephalitis (sspe), (with special reference to psychiatric and psychological evaluations)]. | an atypical case of subacute sclerosing panencephalitis is described, with particular reference to its psychiatric and psychological aspects in the light of the neurological and laboratory data: slow-gamma electrophoresis of the spinal fluid, periodic delta signs in the eeg over about 6 yr, 1/160 blood titre of anti-measles virus antibodies. the history displayed an ingravescent dementia course and the patient's continuing survival for more than 11 yr makes the case the longest recorded in the l ... | 1978 | 733063 |
| interferon induction and action in human lymphoblastoid cells infected with measles virus. | virus replication, cytopathic effect and interferon production were measured in namalva lymphoblastoid cells infected with measles viruses. eight virus strains of different origin or passage history were compared. an inverse relationship seemed to exist between the abilities of strains to induce interferon and to replicate to high titres. two representative strains were found to be highly sensitive to lymphoblastoid cell interferon, when tested in a line of monkey kidney cells (vero). in contras ... | 1978 | 745008 |
| on early diagnosis of subacute sclerosing panencephalitis. | 1978 | 752897 | |
| subacute sclerosing panencephalitis: cerebrospinal fluid, neuropathologic and thymic findings in one case. | 1978 | 752899 | |
| chromosome changes in subacute sclerosing panencephalitis. | in two out of a total of 6 cases of subacute sclerosing panencephalitis with manifest chromosome alterations, chromosome studies were repeated 4 and 5 years of standing, respectively, after manifestation of the disease. in one case the incidence of chromosome alterations increased while in the other no change was found. both cases were clinically similar in their history with remission. | 1978 | 754518 |