Publications

establishment of multiplex rt-pcr for differentiation between rabies virus with and that without mutation at position 333 of glycoprotein.	rabid raccoon dogs (nyctereutes procyonoides koreensis) have been responsible for animal rabies in south korea since the 1990s. a recombinant rabies vaccine strain, designated as erags, was constructed for use as a bait vaccine. therefore, new means of differentiating erags from other rabies virus (rabv) strains will be required in biological manufacturing and diagnostic service centers. in this study, we designed two specific primer sets for differentiation between erags and other rabvs based o ...	2020	32233130
cav-2-mediated gfp and lrrk2g2019s expression in the macaca fascicularis brain.	parkinson's disease is characterized by motor and nonmotor symptoms that gradually appear as a consequence of the selective loss of dopaminergic neurons in the substantia nigra pars compacta. currently, no treatment can slow parkinson's disease progression. inasmuch, there is a need to develop animal models that can be used to understand the pathophysiological mechanisms underlying dopaminergic neuron death. the initial goal of this study was to determine if canine adenovirus type 2 (cav-2) vect ...	2020	32269512
molecular evidence for vaccine-induced canine distemper virus and canine adenovirus 2 coinfection in a fennec fox.	a 61-d-old fennec fox (vulpes zerda), 11 d after receiving a multivalent, modified-live virus vaccine containing canine distemper virus (cdv), canine adenovirus 2 (cadv-2), parainfluenza virus, parvovirus, and canine coronavirus, developed oculonasal discharge, and subsequently convulsions, and hemoptysis, and died. microscopic changes in the cerebrum were evident, including neuronal degeneration and necrosis; intracytoplasmic eosinophilic inclusion bodies were observed in astrocytes. cdv was de ...	2020	32560597
first detection of canine parvovirus 2b dna in a crab-eating fox pup (cerdocyon thous, linnaeus, 1766).	the crab-eating fox (cerdocyon thous) is a small wild mammal present in all brazilian biomes and in some countries of south america. this study aimed to verify the involvement of viral infectious agents in the death of a wild crab-eating fox pup (cerdocyon thous) in brazil. the center for medicine and research of wild animals of the universidade estadual paulista received a free-living crab-eating fox aged approximately 21 days and apparently healthy. after 13 days, the animal presented anorexia ...	2020	33095410
wolf (canis lupus) as canine adenovirus type 1 (cadv-1) sentinel for the endangered cantabrian brown bear (ursus arctos arctos).	canine adenovirus type 1 (cadv-1) causes infectious canine hepatitis (ich) and has recently been described as a cause of death among endangered populations of european brown bear (ursus arctos arctos) in the cantabrian mountain range in asturias, spain. sympatric wild and domestic carnivores can act as reservoirs of the virus and likely spread it into the environment and subsequently transmit it to brown bears. the present work investigates the prevalence and geo-temporal distribution of cadv-1 ...	2021	33527683
patterns and processes of pathogen exposure in gray wolves across north america.	the presence of many pathogens varies in a predictable manner with latitude, with infections decreasing from the equator towards the poles. we investigated the geographic trends of pathogens infecting a widely distributed carnivore: the gray wolf (canis lupus). specifically, we investigated which variables best explain and predict geographic trends in seroprevalence across north american wolf populations and the implications of the underlying mechanisms. we compiled a large serological dataset o ...	2021	33580121
naturally acquired infectious canine hepatitis in two captive maned wolf (chrysocyon brachyurus) puppies.	we report the clinicopathological manifestations of canine adenovirus type 1 (cav 1) infection in captive-born naturally infected maned wolves (chrysocyon brachyurus). two 3-month-old maned wolves presented with lethargy, emesis, dehydration, pallor, hypothermia, leucocytosis, neutrophilia, lymphopaenia and thrombocytopaenia. one of the puppies died shortly after admission, with gross changes that included marked gastrointestinal petechiae, splenomegaly, hepatomegaly and pulmonary haemorrhage. h ...	2021	34340805