Publications
| Title | Abstract | Year Filter | PMID(sorted ascending) Filter |
|---|
| mycobacterium shottsii sp. nov., a slowly growing species isolated from chesapeake bay striped bass (morone saxatilis). | slowly growing, non-pigmented mycobacteria were isolated from striped bass (morone saxatilis) during an epizootic of mycobacteriosis in the chesapeake bay. growth characteristics, acid-fastness and results of 16s rrna gene sequencing were consistent with those of the genus mycobacterium. a unique profile of biochemical reactions was observed among the 21 isolates. a single cluster of eight peaks identified by analysis of mycolic acids (hplc) resembled those of reference patterns but differed in ... | 2003 | 12710607 |
| experimental mycobacteriosis in striped bass morone saxatilis. | striped bass morone saxatilis were infected intraperitoneally with approximately 10(5) mycobacterium marinum, m. shottsii sp. nov., or m. gordonae. infected fish were maintained in a flow-through freshwater system at 18 to 21 degrees c, and were examined histologically and bacteriologically at 2, 4, 6, 8, 17, 26, 36 and 45 wk post-infection (p.i.). m. marinum caused acute peritonitis, followed by extensive granuloma development in the mesenteries, spleen and anterior kidney. granulomas in these ... | 2003 | 12747636 |
| drosophila melanogaster is a genetically tractable model host for mycobacterium marinum. | mycobacterium marinum is a pathogenic mycobacterial species that is closely related to mycobacterium tuberculosis and causes tuberculosis-like disease in fish and frogs. we infected the fruit fly drosophila melanogaster with m. marinum. this bacterium caused a lethal infection in the fly, with a 50% lethal dose (ld(50)) of 5 cfu. death was accompanied by widespread tissue damage. m. marinum initially proliferated inside the phagocytes of the fly; later in infection, bacteria were found both insi ... | 2003 | 12761139 |
| intracellular replication of mycobacterium marinum within dictyostelium discoideum: efficient replication in the absence of host coronin. | mycobacterium marinum causes tuberculosis-like disease in fish and amphibians and has been used as a model mycobacterial species because of its rapid growth and less stringent containment requirements relative to other mycobacterial species. we demonstrate here that m. marinum grows within dictyostelium discoideum cells, allowing the genetic analysis of host factors that may modulate the replication of mycobacterial species. intracellular growth of m. marinum was shown to mimic the properties pr ... | 2003 | 12761143 |
| [bothersome nodules on the fingers of a musician]. | 2003 | 12762204 | |
| [cutaneous nodules to an aquarist]. | 2003 | 12763180 | |
| mycobacterium marinum infections of the distal upper extremities: clinical course and imaging findings in two cases with delayed diagnosis. | mycobacterium marinum infections cause tenosynovitis of the distal upper extremities and develop as a consequence of skin abrasions acquired in contaminated water. we report on two patients whose mr imaging studies showed tenosynovitis of the distal upper extremity secondary to m. marinum. in one patient sequential mr imaging showed development of bony erosions. appropriate treatment was delayed in both patients because the diagnosis was not considered. we report on and discuss the clinical cour ... | 2003 | 12774175 |
| decolorization of malachite green and crystal violet by waterborne pathogenic mycobacteria. | mycobacterium avium, mycobacterium intracellulare, mycobacterium scrofulaceum, mycobacterium marinum, and mycobacterium chelonae tolerate high concentrations of the dyes malachite green and crystal violet. cells of strains of those species decolorized (reduced) both malachite green and crystal violet. because decolorized malachite green lacked antimicrobial activity, the resistance of these mycobacteria could be due, in part, to their ability to decolorize the dyes. small amounts of malachite gr ... | 2003 | 12821489 |
| [tropical fish salesmen's knowledge and behaviour concerning "fish tank granuloma"]. | mycobacterium marinum is responsible for "fish tank granuloma", a chronic and sometimes disabling skin infection, which in france would be the most frequent "atypical" cutaneous mycobacteriosis. tropical fish salesmen are concerned about this disease because they might sell contaminated fish and be infected themselves. a review of the literature indicated that one quarter of the patients were aquarium workers. this original study tested the salesmen's knowledge and behaviour regarding "fish tank ... | 2003 | 12843853 |
| [wrong diagnosis in the case of skin nodules in a musician?]. | 2003 | 12868364 | |
| [granulomatous skin disease after an exotic injury]. | piranhas are feared freshwater fishes commonly found in the waters of southern venezuela to the north of argentina. at present this species is a favourite domesticated article of our aquarists. the authors describe the histopathologic picture of a cutaneous lesion of the right hand thumb of a 60-year old piranha keeper who was bitten by this predatory fish. a firm node with increasing soreness gradually developed in the area of the lesion, and after 7 months the symptoms of the carpal tunnel syn ... | 2003 | 12874906 |
| a prolonged case of mycobacterium marinum flexor tenosynovitis: radiographic and histological correlation, and review of the literature. | we report on a 30-year-old man with prolonged mycobacterium marinum flexor tenosynovitis. due to low clinical suspicion, diagnosis was not made until 8 years after initial presentation. the history and magnetic resonance and tissue examination findings are consistent with mycobacterial tenosynovitis. these findings are presented, together with a review of the literature. | 2003 | 12879295 |
| fish tank exposure and cutaneous infections due to mycobacterium marinum: tuberculin skin testing, treatment, and prevention. | in the present study, 8 patients with soft tissue infection due to mycobacterium marinum are described, and contemporary data on treatment are reviewed. six patients had positive cultures, all patients had cutaneous exposure to fish tanks, 7 had sporotrichoid lesions, and 2 had deep infection. all 7 tested patients had tuberculin skin test reactions > or =10 mm. six patients with disease limited to the skin were successfully treated with 2-drug combination therapy, including clarithromycin, etha ... | 2003 | 12884164 |
| [pulmonary mycobacterioses--frequency of occurrence, clinical spectrum and predisposing factors]. | various types of non-tuberculous mycobacteria can be the aetiologic factors of chronic lung infections especially in patients with underlying chronic lung diseases. the aim of this study is to present the cases of pulmonary mycobacterioses observed in institute of tuberculosis and lung diseases in the years 1995-2001. there were 23 patients, 12 men and 11 women in the age between 35-77 years, mean 56 years. 16 out of 23 patients had underlying respiratory problems, mainly healed tuberculosis (7) ... | 2002 | 12884564 |
| mycobacteriosis in two captive florida manatees (trichechus manatus latirostris). | two male florida manatees (trichechus manatus latirostris) died at the marine aquarium in inagi city, tokyo, japan. acid-fast bacteria were demonstrated in tuberculoid nodules in the lungs from both manatees. mycobacterium marinum and m. fortuitum were isolated from one manatee; m. marinum and m. kansasii were cultured from the second animal. this report confirms the pathogenicity and potentially fatal outcome of mycobacterial infection in manatees. in addition, the pathologic response to infect ... | 2003 | 12885137 |
| requirement for kasb in mycobacterium mycolic acid biosynthesis, cell wall impermeability and intracellular survival: implications for therapy. | mycobacterium tuberculosis infects one-third of the world's population and causes two million deaths annually. the unusually low permeability of its cell wall contributes to the ability of m. tuberculosis to grow within host macrophages, a property required for pathogenesis of infection. mycobacterium marinum is an established model for discovering genes involved in mycobacterial infection. mycobacterium marinum mutants with transposon insertions in the beta-ketoacyl-acyl carrier protein synthas ... | 2003 | 12950920 |
| zebrafish-mycobacterium marinum model for mycobacterial pathogenesis. | we report here the development of a pathogenesis model utilizing mycobacterium marinum infection of zebrafish (danio rerio) for the study of mycobacterial disease. the zebrafish model mimics certain aspects of human tuberculosis, such as the formation of granuloma-like lesions and the ability to establish either an acute or a chronic infection based upon inoculum. this model allows the genetics of mycobacterial disease to be studied in both pathogen and host. | 2003 | 12951238 |
| mycobacterium marinum infection in connecticut: report of four cases. | mycobacterium marinum is emerging as an important human pathogen in the united states. we report four cases incidentally diagnosed from culture of biopsy specimens of wrist lesions at a connecticut inner city hospital between 1996 and 1999. there was no clear association with aquatic exposure and only one patient recalled prior trauma. all were successfully treated with ethambutol and rifampicin. the current literature on the epidemiology, clinical characteristics and management of mycobacterium ... | 2003 | 12956043 |
| transforming growth factor-beta response to mycobacterial infection in striped bass morone saxatilis and hybrid tilapia oreochromis spp. | striped bass (morone saxatilis) and hybrid tilapia (oreochromis spp.) were experimentally infected with mycobacterium marinum. splenic mononuclear cell transforming growth factor-beta (tgf-beta) mrna was measured by reverse transcription quantitative-competitive pcr (rt-qcpcr). in histologic sections of liver and anterior kidney, the area of each section that was occupied by granulomas and the total area of each section were measured by computer-assisted image analysis and compared as a proporti ... | 2003 | 12963276 |
| a recombinant vaccine expressing a mammalian mycobacterium sp. antigen is immunostimulatory but not protective in striped bass. | a recombinant vaccine was constructed for piscine mycobacteriosis utilizing a brucella abortus strain rb51 vector expressing a mammalian mycobacterium sp. 85a antigen. juvenile striped bass were inoculated with the resulting construct at doses equivalent to 10(6), 10(7), 10(8), 10(9), and 10(10) colony-forming units/fish. blood and tissue samples from these fish demonstrated significant specific humoral and cell-mediated immune responses towards the 85a antigen in a dose-dependent manner. howeve ... | 2003 | 12969635 |
| mycobacterium balnei, a new acid-fast bacillus occurring in swimming pools and capable of producing skin lesions in humans. | 1954 | 13188762 | |
| the pathogenic behavior of mycobacterium ulcerans and mycobacterium balnei in the mouse and the developing chick embryo. | 1956 | 13313952 | |
| [different behavior during a leprous reaction induced by the bcg test and the intradermal reaction with a mycobacterium marinum suspension]. | 1956 | 13341124 | |
| homologous and heterologous immunity in infections of mice with mycobacterium ulcerans and mycobacterium balnei. | 1957 | 13444620 | |
| a comparison of the growth of selected mycobacteria in hela, monkey kidney, and human amnion cells in tissue culture. | hela, monkey kidney, and human amnion cells in tissue cultures were compared as sites for the multiplication of strains of tubercle bacilli or original and reduced pathogenicity, and for several other species of mycobacteria capable of causing disease in humans. the arrangement of the pathogenic species inorder of their growth rates in hela cells was mycobacterium fortuitum, mycobacterium balnei, and the "yellow bacillus," followed closely by the tubercle bacillus. this order was also correct fo ... | 1958 | 13491759 |
| the effect of the medium on the cultivation of mycobacterium balnei at 37 degrees. | 1958 | 13525648 | |
| [not available]. | 1958 | 13534034 | |
| specificity of mycobacterial sensitins. i. studies in guinea pigs with purified "tuberculin" prepared from mammalian and avian tubercle bacilli, mycobacterium balnei, and other acid-fast bacilli. | 1961 | 13765311 | |
| mycobacterium balnei infection. report of two cases. | 1962 | 13915109 | |
| [on a skin infection caused by mycobacterium marinum or balnei]. | 1963 | 13961046 | |
| granulomas of the skin due to mycobacterium balnei after abrasions from a fish tank. | 1962 | 13979715 | |
| resistance to infection with virulent tubercle bacilli in mice immunized with viable mycobacterium balnei and unclassified mycobacteria administered aerogenically. | 1963 | 14068430 | |
| effect of environmental temperatures on infection with mycobacterium marinum (balnei) of mice and a number of poikilothermic species. | clark, h fred (communicable disease center, atlanta, ga.), and charles c. shepard. effect of environmental temperatures on infection with mycobacterium marinum (balnei) of mice and a number of poikilothermic species. j. bacteriol. 86:1057-1069. 1963.-an exploration was made of the effect of environmental temperature on infections with mycobacterium marinum of mice, young opossums, and bats, and of 50 species of poikilothermic animals. in artificial medium (7h9 broth) m. marinum grew most rapidly ... | 1963 | 14080772 |
| prepatellar bursitis caused by mycobacterium marinum (balnei); case report, classification, and review of the literature. | 1965 | 14261813 | |
| [treatment of experimental infection by mycobacterium ulcerans and mycobacterium balnei in mice]. | 1965 | 14319166 | |
| [pseudo-epitheliomatous epitheloid granuloma of the penis (smegma granuloma? pseudotuberculosis caused by mycobacterium balnei?)]. | 1965 | 14335401 | |
| studies on mycobacterium ulcerans and mycobacterium balnei. iii. growth in the semi-synthetic culture media of dubos and drug sensitivity in vitro and in vivo. | 1954 | 14363058 | |
| tuberculin sensitivity in children infected with mycobacterium balnei. | 1962 | 14497955 | |
| a bacteriolgic and histopathologic study of skin granuloma due to mycobacterium balnei. | 1961 | 14497956 | |
| interleukin-8 is differentially expressed by human-derived monocytic cell line u937 infected with mycobacterium tuberculosis h37rv and mycobacterium marinum. | although mycobacterium marinum is closely related to mycobacterium tuberculosis h37rv genomically, the clinical outcome in humans is quite different for m. marinum and m. tuberculosis infections. we investigated possible factors in the host macrophages for determining differential pathological responses to m. tuberculosis and m. marinum using an in vitro model of mycobacterial infection. using suppression-subtractive hybridization, we identified 12 differentially expressed genes in the human mon ... | 2003 | 14500465 |
| the secret lives of the pathogenic mycobacteria. | pathogenic mycobacteria, including the causative agents of tuberculosis and leprosy, are responsible for considerable morbidity and mortality worldwide. a hallmark of these pathogens is their tendency to establish chronic infections that produce similar pathologies in a variety of hosts. during infection, mycobacteria reside in macrophages and induce the formation of granulomas, organized immune complexes of differentiated macrophages, lymphocytes, and other cells. this review summarizes our und ... | 2003 | 14527294 |
| emerging pathologies in aquaculture: effects on production and food safety. | infectious diseases represent a limiting factor for the further development of italian aquaculture. the recent introduction and spreading of new pathogens, along with the global climatic change, has contributed to a considerable decrease in trout production. emerging pathologies in rainbow trout culture include viral diseases, e.g. infectious haematopoietic necrosis (ihn), bacterial diseases, such as lactococcosis and visceral flavobacteriosis, and parasitical diseases, e.g. proliferative kidney ... | 2003 | 14535454 |
| mycobacterium marinum: a case of skin granuloma complicated by tenosynovitis of the extensors. | the authors report the case of a male patient who owned a tropical aquarium and who developed a m. marinum skin infection of the wrist. the clinical findings and microbiological features of the case are described, as are the difficulty in providing a prompt diagnosis, and the need for surgical treatment and the use of antibiotics to treat the infection. | 2003 | 14584321 |
| mycobacterium marinum escapes from phagosomes and is propelled by actin-based motility. | mycobacteria are responsible for a number of human and animal diseases and are classical intracellular pathogens, living inside macrophages rather than as free-living organisms during infection. numerous intracellular pathogens, including listeria monocytogenes, shigella flexneri, and rickettsia rickettsii, exploit the host cytoskeleton by using actin-based motility for cell to cell spread during infection. here we show that mycobacterium marinum, a natural pathogen of fish and frogs and an occa ... | 2003 | 14597736 |
| interferon-gamma and skin test responses of schoolchildren in southeast england to purified protein derivatives from mycobacterium tuberculosis and other species of mycobacteria. | the immune responses of schoolchildren in southeast england to mycobacterium tuberculosis and other species of mycobacteria were studied prior to vaccination with bacille calmette-guérin (bcg). data are presented for tuberculin (heaf) skin test and interferon-gamma (ifn-gamma) responses to m. tuberculosis purified protein derivative (ppd), and ifn-gamma responses to ppds from eight other environmental mycobacteria, measured in 424 schoolchildren (13-15 years of age). responses to m. tuberculosis ... | 2003 | 14616789 |
| subtractive hybridization reveals a type i polyketide synthase locus specific to mycobacterium ulcerans. | mycobacterium ulcerans causes buruli ulcer, the third most prevalent mycobacterial infection of immunocompetent humans after tuberculosis and leprosy. recent work has shown that the production by m. ulcerans of mycolactone, a novel polyketide, may partly explain the pathogenesis of buruli ulcer. to search for the genetic basis of virulence in m. ulcerans, we took advantage of the close genetic relationship between m. ulcerans and mycobacterium marinum by performing genomic suppressive subtractiv ... | 2003 | 14617651 |
| lactococcus garvieae in wild red sea wrasse coris aygula (labridae). | lactococcus garvieae infection in wild wrasse coris aygula is reported, and the serological and molecular characteristics of the isolate are described. this is the first evidence of the presence of this pathogen in the red sea, and it follows the recent diagnosis of mycobacterium marinum and streptococcus iniae in wild fish from the same region. whether all 3 pathogens are strains endemic to the red sea, or recent introductions into the region, remains to be determined, but their appearance over ... | 2003 | 14667040 |
| expression analysis of the toll-like receptor and tir domain adaptor families of zebrafish. | the zebrafish genomic sequence database was analysed for the presence of genes encoding members of the toll-like receptors (tlr) and interleukin receptors (il-r) and associated adaptor proteins containing a tir domain. the resulting predictions show the presence of one or more counterparts for the human tlr1, tlr2, tlr3, tlr4, tlr5, tlr7, tlr8, tlr9, il-1r and il-18r genes and one copy of the adaptor genes myd88, mal, trif and sarm. in contrast to data for the pufferfish fugu rubripes, zebrafish ... | 2004 | 14687934 |
| invasive mycobacterium marinum infections. | 2003 | 14725262 | |
| [cutaneous infection with mycobacterium marinum. successful therapy with rifampicin and clarithromycin]. | we report on two male patients with cutaneous mycobacterium marinum infection. after the diagnosis was established by culture, therapy with rifampicin and clarithromycin over a period of three months led to remarkable improvement. | 2004 | 14749869 |
| macro-array and bioinformatic analyses reveal mycobacterial 'core' genes, variation in the esat-6 gene family and new phylogenetic markers for the mycobacterium tuberculosis complex. | to better understand the biology and the virulence determinants of the two major mycobacterial human pathogens mycobacterium tuberculosis and mycobacterium leprae, their genome sequences have been determined recently. in silico comparisons revealed that among the 1439 genes common to both m. tuberculosis and m. leprae, 219 genes code for proteins that show no similarity with proteins from other organisms. therefore, the latter 'core' genes could be specific for mycobacteria or even for the intra ... | 2004 | 14766927 |
| pimf, a mannosyltransferase of mycobacteria, is involved in the biosynthesis of phosphatidylinositol mannosides and lipoarabinomannan. | phosphatidylinositol mannosides (pims) and their related molecules lipomannan (lm) and lipoarabinomannan (lam) are important components of the mycobacterial cell wall. these molecules mediate host-pathogen interactions and exhibit immunomodulatory activities. the biosynthesis of these lipoglycans is not fully understood. in this study, we have identified a mycobacterial gene (rv1500) that is involved in the synthesis of pims. we have named this gene pimf. transposon mutagenesis of pimf of mycoba ... | 2004 | 14960574 |
| mycobacterium-inducible nramp in striped bass (morone saxatilis). | in mammals, the natural resistance-associated macrophage protein 1 gene, nramp1, plays a major role in resistance to mycobacterial infections. chesapeake bay striped bass (morone saxatilis) is currently experiencing an epizootic of mycobacteriosis that threatens the health of this ecologically and economically important species. in the present study, we characterized an nramp gene in this species and obtained evidence that there is induction following mycobacterium exposure. the striped bass nra ... | 2004 | 14977970 |
| images in clinical medicine. mycobacterium marinum. | 2004 | 14985501 | |
| identification of mycobacterium marinum virulence genes using signature-tagged mutagenesis and the goldfish model of mycobacterial pathogenesis. | mycobacterium marinum, a causative agent of fish tuberculosis, is one of the most closely related mycobacterium species (outside the m. tuberculosis complex) to m. tuberculosis, the etiologic agent of human tuberculosis. signature-tagged mutagenesis was used to identify genes of m. marinum required for in vivo survival in a goldfish model of mycobacterial pathogenesis. screening the first 1008 m. marinum mutants led to the identification of 40 putative virulence mutants. dna sequence analysis of ... | 2004 | 15019737 |
| [sporotrichoid atypical mycobacterial infections. antibiotic monotherapy]. | sporotrichoid forms of atypical mycobacterial infections usually do not show a tendency to spontaneous healing. the therapy of choice in such cases is systemic antibiotics. we report three cases of sporotrichoid atypical mycobacterial infections of the skin which healed completely under long-term monotherapy with modern antibiotics (levofloxacin, clarithromycin, minocycline). we recommend confirming the diagnosis by means of culture, followed by monotherapy with low side-effect antibiotics, base ... | 2004 | 15029437 |
| piscine mycobacteriosis: a literature review covering the agent and the disease it causes in fish and humans. | mycobacterium marinum, m. fortuitum and m. chelonae are the etiological agents of fish mycobacteriosis. fish mycobacteriosis is a disseminated infection reported in more than 150 fish species and is usually accompanied by emaciation and death over a period of months to years. granulomas are formed both externally and scattered throughout the internal organs. treatment is in most cases unsatisfactory and the overall recommendation is to destroy the diseased stock, particularly since these pathoge ... | 2004 | 15066718 |
| atypical presentation of mycobacteriosis in a collection of frogfish (antennarius striatus). | severe systemic mycobacteriosis without typical granuloma formation was diagnosed in a group of six mature, captive, striated frogfish antennarius striatus approximately 5 mo after fish originating from brazil were purchased by mote marine laboratory aquarium. beginning 1 mo after spawning, over a period of 9 mo, individuals began to show a variety of signs including egg retention, ocular opacity, poor buoyancy control, ascites with coelomic distension, skin lesions, and anorexia. two fish died, ... | 2003 | 15077718 |
| [skin infection caused by mycobacterium marinum]. | mycobacterium (m.) marinum is a human opportunistic pathogen, capable of causing skin infections and possibly also affecting deeper tissues. the authors describe a case of skin infection caused by m. marinum in a female patient with an appropriate case history. they emphasize the need of close cooperation of the clinician with a microbiologist when establishing the diagnosis. | 2004 | 15100981 |
| buruni ulcer disease. | 2004 | 15114764 | |
| acquisition of hrs, an essential component of phagosomal maturation, is impaired by mycobacteria. | pathogenic mycobacteria survive within macrophages by precluding the fusion of phagosomes with late endosomes or lysosomes. because the molecular determinants of normal phagolysosome formation are poorly understood, the sites targeted by mycobacteria remain unidentified. we found that hrs, an adaptor molecule involved in protein sorting, associates with phagosomes prior to their fusion with late endosomes or lysosomes. recruitment of hrs required the interaction of its fyve domain with phagosoma ... | 2004 | 15121875 |
| recurrent mycobacterium marinum tenosynovitis of the wrist mimicking extraarticular synovial chondromatosis on mr images. | tenosynovitis caused by atypical mycobacterial infections may produce rice bodies within affected tendon sheaths. we report a case of recurrent m. marinum infection involving the flexor tendons within the carpal tunnel in which the rice bodies were mistaken for synovial chondromatosis on mr images. | 2004 | 15127246 |
| the pathogen mycobacterium marinum, a faster growing close relative of mycobacterium tuberculosis, has a single rrna operon per genome. | although mycobacterium marinum and mycobacterium tuberculosis are very closely related they differ significantly in their growth rates. the type strain of m. marinum and one clinical isolate were investigated and, like m. tuberculosis, were found to have a single rrna (rrn) operon per genome located downstream from mura gene and controlled by two promoters. no sequence differences were found that account for the difference in the growth rates of the two species. we infer that m. tuberculosis has ... | 2004 | 15183875 |
| phenoxazine compounds produced by the reactions with bovine hemoglobin show antimicrobial activity against non-tuberculosis mycobacteria. | we studied the anti-microbial effects of phenoxazines produced by the reaction of o-aminophenol or its derivatives with bovine hemoglobin, on seven species of mycobacteria such as mycobacterium tuberculosis, mycobacterium marinum, mycobacterium intracellulare, mycobacterium scrofulaceum, mycobacterium fortuitum, mycobacterium kansasii and mycobacterium smegmatis and some bacteria such as escherichia coli, pseudomonas aeruginosa, salmonella enterica serovar typhimurium, staphylococcus aureus, lis ... | 2004 | 15185971 |
| mycobacterium marinum: mr imaging and clinical course of a rare soft tissue infection. | mycobacterium marinum is a rare cause of soft tissue infections. the imposing mr appearance of the soft tissue involvement is in contrast to the chronic painless clinical manifestation. | 2004 | 15205928 |
| superinfecting mycobacteria home to established tuberculous granulomas. | a central paradox of tuberculosis immunity is that reinfection and bacterial persistence occur despite vigorous host immune responses concentrated in granulomas, which are organized structures that form in response to infection. prevailing models attribute reinfection and persistence to bacterial avoidance of host immunity via establishment of infection outside primary granulomas. alternatively, persistence is attributed to a gradual bacterial adaptation to evolving host immune responses. we sho ... | 2004 | 15220915 |
| new models for the study of mycobacterium-host interactions. | the outcome of mycobacterium infection is determined by a series of complex interactions between the bacteria and host immunity. traditionally, mammalian models and cultured cells have been used to study these interactions. recently, ameba (dictyostelium), fruit flies (drosophila) and zebrafish, amenable to forward genetic screens, have been developed as models for mycobacterial pathogenesis. infection of these hosts with mycobacteria has allowed the dissection of intracellular trafficking pathw ... | 2004 | 15245746 |
| mycobacterium marinum causing tenosynovitis. 'fish tank finger'. | mycobacterium marinum is an unusual atypical mycobacterium with low pathogenicity for humans in comparison with mycobacterium tuberculosis. among the non-tuberculous mycobacterial pathogens, mycobacterium marinum is the most common pathogen to cause skin infections. mycobacterium marinum infection causes chronic cutaneous lesions and in some cases deeper infections such as tenosynovitis, septic arthritis and rarely osteomyelitis. we report the case of a male patient presenting with tenosynovitis ... | 2004 | 15287410 |
| characterization of a trinucleotide repeat sequence (cgg)5 and potential use in restriction fragment length polymorphism typing of mycobacterium tuberculosis. | the genomes of 28 bacterial strains, including mycobacterial species mycobacterium tuberculosis and mycobacterium bovis, were analyzed for the presence of a special class of microsatellite, that of trinucleotide repeat sequences (trs). results of a search of all 10 possible trs motifs (i.e., cct, cgg, ctg, gaa, gat, gta, gtc, gtg, gtt, and tat) with five or more repeating units showed that (cgg)(5) was highly represented within the genomic dna of m. tuberculosis and m. bovis. most of the (cgg)(5 ... | 2004 | 15297495 |
| images in clinical medicine. tenosynovitis due to mycobacterium marinum. | 2004 | 15329429 | |
| a mycobacterial virulence gene cluster extending rd1 is required for cytolysis, bacterial spreading and esat-6 secretion. | initiation and maintenance of infection by mycobacteria in susceptible hosts are not well understood. a screen of mycobacterium marinum transposon mutant library led to isolation of eight mutants that failed to cause haemolysis, all of which had transposon insertions in genes homologous to a region between rv3866 and rv3881c in mycobacterium tuberculosis, which encompasses rd1 (rv3871-rv3879c), a known virulence gene cluster. the m. marinum mutants showed decreased virulence in vivo and failed t ... | 2004 | 15341647 |
| [detection and identification of mycobacteria with polymerase chain reaction-restriction fragment length polymorphism (pcr-rflp) from patients with mycobacterial skin infections]. | to establish a rapid approach to the detection and identification of mycobacteria from lesions of patients with suspected mycobacterial infections. | 2004 | 15489922 |
| mycobacterium marinum strains can be divided into two distinct types based on genetic diversity and virulence. | mycobacterium marinum causes a systemic tuberculosis-like disease in a large number of poikilothermic animals and is used as a model for mycobacterial pathogenesis. in the present study, we infected zebra fish (danio rerio) with different strains of m. marinum to determine the variation in pathogenicity. depending on the m. marinum isolate, the fish developed an acute or chronic disease. acute disease was characterized by uncontrolled growth of the pathogen and death of all animals within 16 day ... | 2004 | 15501758 |
| in vitro response of the striped bass natural resistance-associated macrophage protein, nramp, to lps and mycobacterium marinum exposure. | mycobacteriosis in chesapeake bay (usa) striped bass morone saxatilis is an ongoing disease problem with important economic implications for a large commercial and recreational fishery. additionally, striped bass serve as a reservoir of potential mycobacterial zoonoses. recently, we described a striped bass gene homolog of the natural resistance-associated macrophage protein family (msnramp), which is responsible for resistance to mycobacterial infections in mice. striped bass msnramp is strongl ... | 2004 | 15533797 |
| myths and misconceptions: not all that glitters under the watch is gold (nickel) dermatitis. | 2004 | 15538087 | |
| identification of two mycobacterium marinum loci that affect interactions with macrophages. | mycobacterium marinum is closely related to mycobacterium tuberculosis, the cause of tuberculosis in humans. m. marinum has become an important model system for the study of the molecular mechanisms involved in causing tuberculosis in humans. through molecular genetic analysis of the differences between pathogenic and nonpathogenic mycobacteria, we identified two loci that affect the ability of m. marinum to infect macrophages, designated mel(1) and mel(2). in silico analyses of the 11 putative ... | 2004 | 15557611 |
| mycobacterium marinum: the generalization and specialization of a pathogenic mycobacterium. | mycobacterium marinum is being used increasingly as a model for understanding pathogenic mycobacteria. however, recently discovered differences between m. marinum and m. tuberculosis suggest that adaptation to specialized niches is reflected in unique strategies of pathogenesis. this review emphasizes the areas in which studying m. marinum has made contributions to the understanding of tuberculosis, as well as the potential for using characteristics unique to m. marinum for understanding general ... | 2004 | 15596129 |
| pulmonary infection due to mycobacterium marinum in an immunocompetent patient. | 2005 | 15614719 | |
| immunogenic and protective effects of a dna vaccine for mycobacterium marinum in fish. | mycobacteriosis, caused by numerous mycobacterium spp., can be a devastating disease of both wild and cultured fishes. as no efficacious treatment exists, a vaccine against fish mycobacteriosis is essential for prevention and control of this disease. thus, a dna vaccine was constructed using the mycobacterium marinum ag85a gene that encodes one of the major secreted fibronectin-binding proteins of mycobacterium spp., which was isolated and then subcloned into a commercially available eukaryotic ... | 2005 | 15621306 |
| ultrastructure of mycobacterium marinum granuloma in striped bass morone saxatilis. | an emerging epizootic of mycobacteriosis currently threatens striped bass morone saxatilis populations in chesapeake bay, usa. several species of mycobacteria, including mycobacterium marinum, species resembling m. avium, m. gordonae, m. peregrinum, m. scrofulaceum and m. terrae, and the new species m. shottsii have been isolated from diseased and healthy bass. in this study, we describe the ultrastructure of developing m. marinum granulomas in experimentally infected bass over a period of 45 wk ... | 2004 | 15648839 |
| [persistent erythematous nodule on the back of the hand]. | 2005 | 15685440 | |
| actin-based motility of intracellular pathogens. | the actin cytoskeleton is harnessed by several pathogenic bacteria that are capable of entering into non-phagocytic cells, the so-called 'invasive bacteria'. among them, a few also exploit the host actin cytoskeleton to move intra- and inter-cellularly. our knowledge of the basic mechanisms underlying actin-based motility has dramatically increased and the list of bacteria that are able to move in this way is also increasing including not only listeria, shigella and rickettsia species but also m ... | 2005 | 15694855 |
| mycobacterium marinum infections in fish and humans in israel. | israeli mycobacterium marinum isolates from humans and fish were compared by direct sequencing of the 16s rrna and hsp65 genes, restriction mapping, and amplified fragment length polymorphism analysis. significant molecular differences separated all clinical isolates from the piscine isolates, ruling out the local aquaculture industry as the source of human infections. | 2005 | 15695698 |
| genotyping mycobacterium ulcerans and mycobacterium marinum by using mycobacterial interspersed repetitive units. | a novel category of variable tandem repeats (vntr) called mycobacterial interspersed repetitive units (mirus) has been identified for mycobacterium ulcerans (n = 39), m. marinum (n = 27), and one related organism. fifteen miru loci were identified in the genome of m. marinum and were used to genotype m. ulcerans, m. marinum, and an m. marinum-like organism that is considered a possible missing link between m. marinum and m. ulcerans. seven miru loci were polymorphic, and locus-specific pcrs for ... | 2005 | 15716434 |
| common evolutionary origin for the unstable virulence plasmid pmum found in geographically diverse strains of mycobacterium ulcerans. | the 174-kb virulence plasmid pmum001 in mycobacterium ulcerans epidemic strain agy99 harbors three very large and homologous genes that encode giant polyketide synthases (pks) responsible for the synthesis of the lipid toxin mycolactone. deeper investigation of m. ulcerans agy99 resulted in identification of two types of spontaneous deletion variants of pmum001 within a population of cells that also contained the intact plasmid. these variants arose from recombination between two 8-kb sections o ... | 2005 | 15716437 |
| mycobacterium marinum infections of the upper extremity. | a significant number of patients infected with mycobacterium marinum have been treated at the curtis national hand center in baltimore, maryland. the purpose of this study was to review the authors' experience with m. marinum infections of the upper extremity. twenty-nine patients were identified and their charts were reviewed for all factors related to diagnosis and treatment. the most common presenting symptoms were swelling (n = 25) and pain (n = 14). only 69 percent of patients could correla ... | 2005 | 15731663 |
| mycobacterium marinum infection. | a 49-year-old man presented with nodules on his right hand after a history of mycobacterium marinum infection recently treated with rifampin and clarithromycin. the patient has an aquarium with betta fish (siamese fighting fish). | 2004 | 15748591 |
| functional analysis and annotation of the virulence plasmid pmum001 from mycobacterium ulcerans. | the presence of a 174 kb plasmid called pmum001 in mycobacterium ulcerans, the first example of a mycobacterial plasmid encoding a virulence determinant, was recently reported. over half of pmum001 is devoted to six genes, three of which encode giant polyketide synthases (pks) that produce mycolactone, an unusual cytotoxic lipid produced by m. ulcerans. in this present study the remaining 75 non-pks-associated protein-coding sequences (cds) are analysed and it is shown that pmum001 is a low-copy ... | 2005 | 15758215 |
| a case of granulomatous skin lesions caused by mycobacterium marinum in the campania region. | the diagnosis of cutaneous mycobacterium marinum infection is frequently presumptive, as detection by conventional methods is difficult. we describe a patient with granulomatous skin lesions on the right dorsal hand and forearm. histological examinations were presumptive for mycobacterium lesions. we identified mycobacterium marinum directly in the patient's lesional skin biopsy combining polymerase chain reaction (pcr) amplification using mycobacterium genus-specific primers, and subsequent res ... | 2005 | 15782631 |
| simultaneous chronic cutaneous infection with mycobacterium marinum and nocardia asteroides. | 2005 | 15793529 | |
| [mycobacterium marinum nodular lymphangitis]. | 2005 | 15811287 | |
| multilocus variable-number tandem repeat typing of mycobacterium ulcerans. | the apparent genetic homogeneity of mycobacterium ulcerans contributes to the poorly understood epidemiology of m. ulcerans infection. here, we report the identification of variable number tandem repeat (vntr) sequences as novel polymorphic elements in the genome of this species. a total of 19 potential vntr loci identified in the closely related m. marinum genome sequence were screened in a collection of 23 m. ulcerans isolates, one mycobacterium species referred to here as an intermediate spec ... | 2005 | 15814964 |
| transcriptome profiling of adult zebrafish at the late stage of chronic tuberculosis due to mycobacterium marinum infection. | the mycobacterium marinum-zebrafish infection model was used in this study for analysis of a host transcriptome response to mycobacterium infection at the organismal level. rna isolated from adult zebrafish that showed typical signs of fish tuberculosis due to a chronic progressive infection with m. marinum was compared with rna from healthy fish in microarray analyses. spotted oligonucleotide sets (designed by sigma-compugen and mwg) and affymetrix genechips were used, in total comprising 45,46 ... | 2005 | 15829308 |
| clinical patterns of cutaneous nontuberculous mycobacterial infections. | cutaneous nontuberculous mycobacterial infections result from external inoculation, spread of a deeper infection, or haematogenous spread of a disseminated infection. there are two species-specific infections (fish-tank or swimming-pool granuloma, due to mycobacterium marinum, and buruli ulcer, caused by m. ulcerans). most infections, however, produce a nonspecific clinical picture. | 2005 | 15840105 |
| genomic annotation and expression analysis of the zebrafish rho small gtpase family during development and bacterial infection. | the zebrafish genomic sequence database was analyzed for the presence of genes encoding members of the rho small gtpases. the analysis shows the presence of 32 zebrafish rho genes representing one or more homologs of the human rhoa, rnd3, rhof, rhog, rhoh, rhoj, rhou, rhov, cdc42, rac1, rac2, rac3, rnd1, rhobtb1, rhobtb2, rhobtb3, and rhot1 genes. by expression analysis using reverse transcriptase-pcr we show that at least 20 of the predicted zebrafish small gtpase genes are expressed in the adu ... | 2005 | 15894457 |
| a newly discovered mycobacterial pathogen isolated from laboratory colonies of xenopus species with lethal infections produces a novel form of mycolactone, the mycobacterium ulcerans macrolide toxin. | mycobacterium ulcerans, the causative agent of buruli ulcer, produces a macrolide toxin, mycolactone a/b, which is thought to play a major role in virulence. a disease similar to buruli ulcer recently appeared in united states frog colonies following importation of the west african frog, xenopus tropicalis. the taxonomic position of the frog pathogen has not been fully elucidated, but this organism, tentatively designated mycobacterium liflandii, is closely related to m. ulcerans and mycobacteri ... | 2005 | 15908356 |
| amputation of a mycobacterium marinum-infected hindlimb in an african bullfrog (pyxicephalus adspersus). | 2005 | 15937245 | |
| mycobacterium marinum with different responses to second-generation tetracyclines. | persistent cutaneous infections with mycobacterium marinum can follow exposure of injured skin to contaminated water or fish, and can be treated with second-generation tetracyclines in addition to other antimicrobials. due to the rarity of this infection, there are few data comparing the different treatment alternatives. | 2005 | 15941446 |
| [mycobacterium marinum tenosynovitis of the abductors]. | infection with mycobacterium marinum is rare and usually produces cutaneous lesions. we report here two cases of tenosynovitis of abductor muscles. | 2005 | 15962499 |
| [nodular dermohypodermatitis of the right arm]. | 2005 | 15962505 |