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production of l-lactic acid from a green microalga, hydrodictyon reticulum, by lactobacillus paracasei la104 isolated from the traditional korean food, makgeolli.the freshwater microalga, hydrodictyon reticulum, that contained 47.5% reducing sugars including 35% glucose was used as substrate for the production of l-lactic acid (la) by la-producing bacteria. lactobacillus paracasei la104 was selected for fermentation in a 5-l fermentor since it was able to grow at ph 3, 60g la/l, 200g glucose/l, 125g nacl/l, and 45°c and produced over 97.3% optically pure l-lactic acid with glucose as a substrate. simultaneous saccharification and cofermentation from h. r ...201222336740
identification of lactic acid bacteria in traditional fermented yak milk and evaluation of their application in fermented milk products.in this study, 53 strains of lactic acid bacteria (lab) isolated from xueo, a traditional fermented yak milk in the western sichuan plateau of china, were identified and their use in fermented milk was evaluated. all gram-positive and catalase-negative strains were divided into 6 groups at the level of 87% similarity using amplified ribosomal dna restriction analysis. these groups were identified as 6 species using 16s rdna sequence analysis and atpa gene analysis. the dominant lab strains in xu ...201222365191
sublingual administration of lactobacillus paracasei kw3110 inhibits th2-dependent allergic responses via upregulation of pd-l2 on dendritic cells.lactic acid bacteria have potential in immunomodulation therapy, but their clinical efficacy and underlying mechanisms are unclear. we aimed to clarify the anti-allergic immune responses induced by intragastric and sublingual administration of heat-killed lactobacillus paracasei kw3110 and lactobacillus acidophilus l-92. the kw3110 strain (but not the l-92 strain) enhanced ovalbumin (ova)-induced expression of ccr-7 and pd-l2 in murine dendritic cells (dcs), and strongly inhibited il-5 and il-13 ...201222386865
in vitro evaluation of mtad and nisin in combination against common pathogens associated with root canal infection.many pathogenic microorganisms were found in an infected root canal. the object of this study was to evaluate the effect of mtad in combination with nisin on the pathogens associated with root canal infection.201222414835
probiotic effects on t-cell maturation in infants during weaning.we previously reported that feeding the probiotic lactobacillus paracasei ssp. paracasei f19 (lf19) during weaning reduced the cumulative incidence of eczema.201222417212
effects of probiotics and antibiotics on the intestinal homeostasis in a computer controlled model of the large intestine.antibiotic associated diarrhea and clostridium difficile infection are frequent complications of broad spectrum antibiotic therapy. probiotic bacteria are used as therapeutic and preventive agents in these disorders, but the exact functional mechanisms and the mode of action are poorly understood. the effects of clindamycin and the probiotic mixture vsl#3 (containing the 8 bacterial strains streptococcus thermophilus, bifidobacterium breve, bifidobacterium longum, bifidobacterium infantis, lacto ...201222452835
antimicrobial susceptibility of microflora from ovine cheese.strains identified in ovine cheese and bryndza by matrix-assisted laser desorption/ionization time-of-flight analysis belonged to ten species of non-enterococcal lactic acid bacteria and included lactobacillus casei/lactobacillus paracasei, lactobacillus plantarum, lactobacillus rhamnosus, lactobacillus helveticus, lactobacillus delbrueckii, lactobacillus fermentum, lactobacillus brevis, lactococcus lactis, pediococcus pentosaceus and pediococcus acidilactici. the susceptibility toward antibioti ...201222491987
direct lactic acid fermentation of jerusalem artichoke tuber extract using lactobacillus paracasei without acidic or enzymatic inulin hydrolysis.lactic acid fermentation of jerusalem artichoke tuber was performed with strains of lactobacillus paracasei without acidic or enzymatic inulin hydrolysis prior to fermentation. some strains of l. paracasei, notably kctc13090 and kctc13169, could ferment hot-water extract of jerusalem artichoke tuber more efficiently compared with other lactobacillus spp. such as l. casei type strain kctc3109. the l. paracasei strains could utilize almost completely the fructo-oligosaccharides present in jerusale ...201222516247
lactocepin secreted by lactobacillus exerts anti-inflammatory effects by selectively degrading proinflammatory chemokines.the intestinal microbiota has been linked to inflammatory bowel diseases (ibd), and oral treatment with specific bacteria can ameliorate ibd. one bacterial mixture, vsl#3, containing lactobacillus, bifidobacterium, and streptococcus, was clinically shown to reduce inflammation in ibd patients and normalize intestinal levels of ip-10, a lymphocyte-recruiting chemokine, in a murine colitis model. we identified lactobacillus paracasei prtp-encoded lactocepin as a protease that selectively degrades ...201222520466
gut balance, a synbiotic supplement, increases fecal lactobacillus paracasei but has little effect on immunity in healthy physically active individuals.synbiotic supplements, which contain multiple functional ingredients, may enhance the immune system more than the use of individual ingredients alone. a double blind active controlled parallel trial over a 21 d exercise training period was conducted to evaluate the effect of gut balance™, which contains lactobacillus paracasei subsp. paracasei (l. casei 431®), bifidobacterium animalis ssp. lactis (bb-12®), lactobacillus acidophilus (la-5®), lactobacillus rhamnosus (lgg®), two prebiotics (raftili ...201722572834
a novel lactic acid bacterium for the production of high purity l-lactic acid, lactobacillus paracasei subsp. paracasei chb2121.fermentation-derived lactic acid has several potential industrial uses as an intermediate carbon chemical and a raw material for biodegradable polymer. we therefore undertook the identification of a novel bacterial strain that is capable of producing high concentrations of lactic acid and has potential commercial applications. a novel l(+)-lactic acid producing bacterium, lactobacillus paracasei subsp. paracasei chb2121 was isolated from soil obtained near an ethanol production factory and ident ...201222578598
suitability of a probiotic lactobacillus paracasei strain as a starter culture in olive fermentation and development of the innovative patented product "probiotic table olives".probiotic bacteria are generally available for consumers as concentrated preparations or incorporated in milk-based foods. due to an increased interest of the market for probiotic foods as well as to meet a demand of industry for innovation, a new kind of probiotic food has been developed using table olives as a carrier. green table olives, produced according to the spanish-style, are obtained by a fermentation which can be carried out by spontaneous microflora, even if the use of starter cultur ...201222586426
inventory of non starter lactic acid bacteria from ripened parmigiano reggiano cheese as assessed by a culture dependent multiphasic approach.the objective of this study was to investigate microbial species diversity and strain complexity of the cultivable non starter lactic acid bacteria (nslab) occurring in 31 ripened parmigiano reggiano (pr) cheeses. dereplication of 127 lactobacilli isolates by (gtg)(5)-pcr fingerprinting yielded a total of 51 genotypes. phylogenetic relatedness of all the genotypes with known lactobacillus species was determined by a novel combined amplified 16s rdna restriction analysis (16s-ardra), species-spec ...201222626626
lactobacillus paracasei and lactobacillus plantarum strains downregulate proinflammatory genes in an ex vivo system of cultured human colonic mucosa.significant health benefits have been demonstrated for certain probiotic strains through intervention studies; however, there is a shortage of experimental evidence relative to the mechanisms of action. here, noninvasive experimental procedure based on a colon organ culture system has been used that, in contrast to most experimental in vitro models reported, can preserve natural immunohistochemical features of the human mucosa. this system has been used to test whether commensal lactobacilli (la ...201322669626
effects of bile salt deconjugation by probiotic strains on the survival of antibiotic-resistant foodborne pathogens under simulated gastric conditions.this study was designed to evaluate the effects of bile acid deconjugation by probiotic strains on the antibiotic susceptibility of antibiotic-sensitive and multiple antibiotic-resistant salmonella typhimurium and staphylococcus aureus. eight probiotic strains, bifidobacterium longum b6, lactobacillus acidophilus adh, lactobacillus brevis kacc 10553, lactobacillus casei kacc 12413, lactobacillus paracasei atcc 25598, lactobacillus rhamnosus gg, leuconostoc mesenteroides kacc 12312, and pediococc ...201222691477
functional foods as carriers for synbio®, a probiotic bacteria combination.the popularity of functional foods continues to increase as consumers desire flavorful foods that will fulfil their health needs. among these foods, probiotics may exert positive effects on the composition of gut microbiota and overall health. however, in order to be beneficial, the bacterial cultures have to remain live and active at the time of consumption. the aim of this study was to develop new probiotic food products, such as seasoned cheeses, salami, chocolate and ice-cream with a final p ...201222727086
intragastric and intranasal administration of lactobacillus paracasei ncc2461 modulates allergic airway inflammation in mice.introduction. preclinical and clinical evidences for a role of oral probiotics in the management of allergic diseases are emerging. aim. we aimed at testing the immunomodulatory effects of intranasal versus intragastric administration of lactobacillus paracasei ncc2461 in a mouse model of allergic airway inflammation and the specificity of different probiotics by comparing l. paracasei ncc2461 to lactobacillus plantarum ncc1107. methods. l. paracasei ncc2461 or l. plantarum ncc1107 strains were ...201222762009
immunomodulating and anti-infective effects of a novel strain of lactobacillus paracasei that strongly induces interleukin-12.several studies have demonstrated that some strains of lactic acid bacteria (lab) can elicit natural killer (nk) cell activities via interleukin-12 (il-12) induction and protect against influenza virus (ifv) infection. lab strains that strongly induce il-12 are expected to be effective in protecting against ifv infection. in this study, we screened 85 strains for their ability to induce the in vitro production of il-12, and lactobacillus paracasei molac-1 most strongly induced il-12. to examine ...201222775119
perinatal maternal administration of lactobacillus paracasei ncc 2461 prevents allergic inflammation in a mouse model of birch pollen allergy.the hygiene hypothesis implies that microbial agents including probiotic bacteria may modulate foetal/neonatal immune programming and hence offer effective strategies for primary allergy prevention; however their mechanisms of action are poorly understood. we investigated whether oral administration of lactobacillus paracasei ncc 2461 to mothers during gestation/lactation can protect against airway inflammation in offspring in a mouse model of birch pollen allergy, and examined the immune mechan ...201222792257
characterization and purification of a bacteriocin from lactobacillus paracasei subsp. paracasei bmk2005, an intestinal isolate active against multidrug-resistant pathogens.a strain of lactobacillus paracasei subsp. paracasei bmk2005 isolated from healthy infant faeces has shown a remarkable antibacterial activity against 32 bacterial pathogenic strains of human clinical isolates. among them, 13 strains belonging to species of escherichia coli, citrobacter freundii, citrobacter diversus, klebsiella oxytoca, enterobacter cloacae and pseudomonas aeruginosa were resistant to cefotaxime (ctx) and ceftazidime (caz), and 4 strains of staphylococcus aureus were resistant ...201122805936
bioconversion of oleuropein to hydroxytyrosol by lactic acid bacteria.the aim of this work is to study the conversion of oleuropein-a polyphenol present in olives and olive oil by-products-into hydroxytyrosol, a polyphenol with antioxidant and antibacterial properties. the hydrolysis reaction is performed by lactic acid bacteria. six bacterial strains (lactobacillus plantarum 6907, lactobacillus paracasei 9192, lactobacillus casei, bifidobacterium lactis bo, enterococcus faecium 32, lactobacillus lafti 10) were tested under aerobic and anaerobic conditions. the ol ...201222806118
human intestinal dendritic cells decrease cytokine release against salmonella infection in the presence of lactobacillus paracasei upon tlr activation.probiotic bacteria have been shown to modulate immune responses and could have therapeutic effects in allergic and inflammatory disorders. however, little is known about the signalling pathways that are engaged by probiotics. dendritic cells (dcs) are antigen-presenting cells that are involved in immunity and tolerance. monocyte-derived dendritic cells (modcs) and murine dcs are different from human gut dcs; therefore, in this study, we used human dcs generated from cd34+ progenitor cells (hemat ...201222905233
characterization of ethanol fermentation waste and its application to lactic acid production by lactobacillus paracasei.in this study, an ethanol fermentation waste (efw) was characterized for use as an alternative to yeast extract for bulk fermentation processes. efw generated from a commercial plant in which ethanol is produced from cassava/rice/wheat/barley starch mixtures using saccharomyces cerevisiae was used for lactic acid production by lactobacillus paracasei. the effects of temperature, ph, and duration on the autolysis of an ethanol fermentation broth (efb) were also investigated. the distilled efw (de ...201322907566
accelerated ripening of caciocavallo pugliese cheese with attenuated adjuncts of selected nonstarter lactobacilli.the nonstarter lactic acid bacteria lactobacillus plantarum cc3m8, lactobacillus paracasei cc3m35, and lactobacillus casei lc01, previously isolated from aged caciocavallo pugliese cheese or used in cheesemaking, were used as adjunct cultures (ac) or attenuated (by sonication treatment) adjunct cultures (aac) for the manufacture of caciocavallo pugliese cheese on an industrial scale. preliminary studies on the kinetics of growth and acidification and activities of several enzymes of aac were cha ...201222916882
fermentation of sugars and sugar alcohols by plaque lactobacillus strains.the objective was to analyse the ability of lactobacillus strains isolated from supragingival plaque of subjects with hyposalivation and from healthy controls to ferment sugars and sugar alcohols.201322956128
survival of microencapsulated probiotic lactobacillus paracasei lbc-1e during manufacture of mozzarella cheese and simulated gastric digestion.an erythromycin-resistant strain of probiotic lactobacillus paracasei ssp. paracasei lbc-1 (lbc-1e) was added to part-skim mozzarella cheese in alginate-microencapsulated or free form at a level of 10(8) and 10(7)cfu/g, respectively. survival of lbc-1e and total lactic acid bacteria (lab) was investigated through the pasta filata process of cheese making (in which the cheese curd was heated to 55 °c and stretched in 70 °c-hot brine), followed by storage at 4 °c for 6 wk and simulated gastric and ...201222981567
effect of a non-lethal high pressure homogenization treatment on the in vivo response of probiotic lactobacilli.low levels of high pressure of homogenization (hph) can be applied directly to lactic acid bacteria cells in order to enhance some functional properties. in a previous work we observed that a 50 mpa hph treatment increased lactobacillus paracasei a13 hydrophobicity and resistance to simulated gastric digestion. the aim of this work was to assess the in vivo effects of hph treatment applied to probiotic lactobacilli on their interaction capacity with the gut and on their ability to induce iga cel ...201222986193
inhibition of fe-induced colon oxidative stress by lactobacilli in mice.iron (fe) can promote hydrogen peroxide (h(2)o(2)) and hydroxyl radical generation in the colonic surface and promote growth of fe-dependent bacteria. some lactobacillus strains are resistant to oxygen free-radicals, allowing them to survive in a fe-modulated mucosal environment and influence colon microbial ecology and redox state. here, we investigated the capacity of lactobacilli with different antioxidant abilities to modify the bacterial profile and prevent oxidative stress in the colon of ...201322990462
protective effect of lactofermented red beetroot juice against aberrant crypt foci formation, genotoxicity of fecal water and oxidative stress induced by 2-amino-1-methyl-6-phenylimidazo[4,5-b] pyridine in rats model.the aim of the study was to investigate the effects of beetroot juice fermented by lactobacillus brevis 0944 and lactobacillus paracasei 0920 (fbj) on carcinogen induction of aberrant crypt foci (acf) in rat colon. 2-amino-1-methyl-6-phenylimidazo[4,5-b] pyridine (phip) was used as carcinogen, which was administrated intragastrically at a dose of 10 μg/day, every day of the experiment. additionally, we investigated the cytotoxicity and genotoxicity of fecal water from experimental animals in the ...201222995401
impact of lactobacilli on orally acquired listeriosis.listeria monocytogenes is a foodborne pathogen that crosses the intestinal barrier and disseminates within the host. here, we report a unique comprehensive analysis of the impact of two lactobacillus species, lactobacillus paracasei cncm i-3689 and lactobacillus casei bl23, on l. monocytogenes and orally acquired listeriosis in a gnotobiotic humanized mouse model. we first assessed the effect of treatment with each lactobacillus on l. monocytogenes counts in host tissues and showed that each dec ...201223012479
antiproliferative and proapoptotic effects of viable or heat-killed lactobacillus paracasei impc2.1 and lactobacillus rhamnosus gg in hgc-27 gastric and dld-1 colon cell lines.data from literature suggest the possible use of probiotics as chemopreventive agents against colon cancer, but few investigations are available on their effects on gastric cancer proliferation. in our previous study, a specific lactobacillus, strain l. paracasei impc2.1, was demonstrated to colonize the human gut and positively affect fecal bacteria and biochemical parameters. the aims of the present study were to investigate the effects of l. paracasei impc2.1, comparing them with those of lac ...201223061912
[viability and efects of the probiotic lactobacillus aracaseissp aracasei in chilean low-fat gauda cheese].the objective of this study is to infer the survival of the probiotic lactobacillus paracasei ssp paracasei added during the processing of low-fat gouda cheese, during the maturation (21 days) and the commercialization (14 days), in order to see the influence that this organism has on the quality of the product. the treatments were: ti (control): gouda with normal fat content; t2: low fat gouda cheese (qgs) t3: qgs, with additional probiotic added with the initial culture; t4: qgs, with the prob ...201123094525
identification of microbiota present on the surface of taleggio cheese using pcr-dgge and rapd-pcr.microbial dna from 9 batches of taleggio pdo cheese sampled at various times during ripening, brines, swabs of wooden shelves used for cheese dry-salting, and 13 commercial cheeses were analyzed by denaturing gradient gel electrophoresis (pcr-dgge) and/or random amplification of polymorphic dna (rapd-pcr). sequencing allowed the detection of 12 genera, 27 species, and 2 unclassified bacteria. molecular analysis allowed for the detection of microorganisms not previously associated with taleggio s ...201223094819
dried tomato-flavored probiotic cream cheese with lactobacillus paracasei.a dried tomato-flavored probiotic cream cheese (p) containing lactobacillus paracasei lpc-37 was developed for the purpose of this study. the same product, but without probiotic addition (c) was used as control. lactococcus lactis subsp. lactis and lactococcus lactis subsp. cremoris were used as lactic starter cultures. chemical composition analyses and sensory tests were performed on days 1 and 7, respectively. titratable acidity, ph value and l. paracasei population were determined every 7 d d ...201223126664
high-fibre diet and lactobacillus paracasei b21060 in symptomatic uncomplicated diverticular disease.to investigate in symptomatic uncomplicated diverticular disease the efficacy of symbiotics associated with a high-fibre diet on abdominal symptoms.201223139608
induced apoptosis of th2 lymphocytes and inhibition of airway hyperresponsiveness and inflammation by combined lactic acid bacteria treatment.several lactic acid bacteria (lab) demonstrably regulate the immune system and inhibit allergic disease. this study examined whether oral feeding of either lactobacillus paracasei (l. paracasei) bb5 and/or lactobacillus rhamnosus (l. rhamnosus) bb1 suppresses ovalbumin (ova)-induced airway hyperresponsiveness (ahr) and inflammation in a murine model. ova-specific immune responses, cell profile of bronchoalveolar lavage fluid (balf), and airway ahr were assessed following ova and methacholine cha ...201323142092
stability evaluation of freeze-dried lactobacillus paracasei subsp. tolerance and lactobacillus delbrueckii subsp. bulgaricus in oral capsules.freeze-drying is a common preservation technology in the pharmaceutical industry. various studies have investigated the effect of different cryoprotectants on probiotics during freeze-drying. however, information on the effect of cryoprotectants on the stability of some lactobacillus strains during freeze-drying seems scarce. therefore, the aim of the present study was to establish production methods for preparation of oral capsule probiotics containing lactobacillus paracasei subsp. tolerance a ...201223181077
metabolism of milk fat globule membrane components by nonstarter lactic acid bacteria isolated from cheese.the objective of this study was to investigate how components present in the milk fat globule membrane (mfgm) may be used for growth and survival by cheese-ripening lactobacilli. this was achieved by analyzing metabolites produced during incubation on appropriate media. the lactobacilli investigated were able to utilize components from the mfgm throughout a 24-d incubation period. we observed an apparent connection between the higher proteolytic activity of lactobacillus paracasei inf448 and its ...201323182353
factors affecting adhesion of lactic acid bacteria to caco-2 cells and inhibitory effect on infection of salmonella typhimurium.in this study, seven strains isolated from mustard leaf kimchi were screened for their tolerance to simulated gastric and bile juices, the adhesive properties to caco-2 cells, and the inhibition ability of salmonella typhimurium atcc 29631 adhesion. lactobacillus acidophilus gk20, lactobacillus paracasei gk74, and lactobacillus plantarum gk81, which were resistant to bile as well as gastric juices, possessed high bile-salt hydrolase (bsh) activity towards both sodium glycocholate and sodium taur ...201223221537
impact of probiotic feeding during weaning on the serum lipid profile and plasma metabolome in infants.the gut microbiome interacts with the host in the metabolic response to diet, and early microbial aberrancies may be linked to the development of obesity and metabolic disorders later in life. probiotics have been proposed to affect metabolic programming and blood lipid levels, although studies are lacking in infants. here, we report on the lipid profile and global metabolic response following daily feeding of probiotics during weaning. a total of 179 healthy, term infants were randomised to dai ...201323228571
development of probiotic tablets using microparticles: viability studies and stability studies.alternative vectors to deliver viable cells of probiotics, to those conferring limited resistance to gastrointestinal conditions, still need to be sought. therefore the main goal of the study was to develop tablets able to protect entrapped probiotic bacteria from gastric acidity, thus providing an easily manufacturing scale-up dosage form to deliver probiotics to the vicinity of the human colon. whey protein concentrate microparticles with lactobacillus paracasei l26 were produced by spray-dryi ...201323233282
enteroglial-derived s100b protein integrates bacteria-induced toll-like receptor signalling in human enteric glial cells.enteric glial cells (egc) have been suggested to participate in host-bacteria cross-talk, playing a protective role within the gut. the way egc interact with microorganisms is still poorly understood. we aimed to evaluate whether: egc participate in host-bacteria interaction; s100b and toll-like receptor (tlr) signalling converge in a common pathway leading to nitric oxide (no) production.201423292665
isolation, identification and characterisation of three novel probiotic strains (lactobacillus paracasei cncm i-4034, bifidobacterium breve cncm i-4035 and lactobacillus rhamnosus cncm i-4036) from the faeces of exclusively breast-fed infants.the aim of the present study was to isolate, identify and characterise novel strains of lactic acid bacteria and bifidobacteria with probiotic properties from the faeces of exclusively breast-fed infants. of the 4680 isolated colonies, 758 exhibited resistance to low ph and tolerance to high concentrations of bile salts; of these, only forty-two exhibited a strong ability to adhere to enterocytes in vitro. the identities of the isolates were confirmed by 16s ribosomal rna (rrna) sequencing, whic ...201323360881
competitive inhibition of three novel bacteria isolated from faeces of breast milk-fed infants against selected enteropathogens.numerous in vitro and in vivo studies conducted using different probiotic micro-organisms have demonstrated their ability to interfere with the growth and virulence of a variety of enteropathogens. the reported beneficial effects of the use of probiotics to complement antibiotic therapy or prevent diarrhoea or gastrointestinal infection in infants have increased in recent years. in the present study, we demonstrated the capacity of supernatants obtained from three novel probiotics (lactobacillus ...201323360882
effects of intraduodenal injection of lactobacillus brevis sbc8803 on autonomic neurotransmission and appetite in rodents.lactobacilli provide several health benefits to mammals, including humans. we previously observed that in rats, intraduodenal injection of lactobacillus johnsonii la1 elevated efferent gastric vagal nerve activity (efferent-gvna), while lactobacillus paracasei st11 suppressed efferent-gvna, and thereby increased or decreased food intake. to determine the function of lactobacillus brevis (sbc8803), its effect on food intake was examined by providing food containing heat-killed sbc8803 to mice. we ...201323391754
applied development of crude enzyme from bacillus cereus in prebiotics and microbial community changes in soil.the chitosanase and chitinase activity were revealed in the culture supernatant of bacillus cereus tku027 with shrimp head powder (shp) as the sole carbon/nitrogen source. the chitosan with 60% degree of deacetylation (dd) was depolymerized by tku027 crude enzyme. the low dp oligomers stimulated the growth of lactobacillus paracasei bcrc12193 and lactobacillus kefir bcrc14011 in a mrs broth supplemented with low dp oligomers for 12 h. conversely, the high dp oligomers (0.1%) had potent inhibitor ...201223399269
cytokine responses in the japanese pufferfish (takifugu rubripes) head kidney cells induced with heat-killed probiotics isolated from the mongolian dairy products.cytokine responses in the japanese pufferfish (takifugu rubripes) head kidney (hk) cells to heat-killed lactic acid bacteria probiotics isolated from the mongolian dairy products were investigated by transcriptomic examination. the hk cells were incubated with two heat-killed bacteria, namely lactobacillus paracasei spp. paracasei (strain 06tca22) and l. plantarum (strain 06cc2) and the responses of 16 cytokine genes at 0 (control), 1, 4, 8, 12, 24 and 48 h post-stimulation were assayed by multi ...201323422813
lactobacillus paracasei bej01 prevents immunotoxic effects during chronic zearalenone exposure in balb/c mice.zearalenone (zen) is an estrogenic mycotoxin produced by numerous fusarium species in pre- or post-harvest cereals. zen displays a potent estrogenicity in livestock and also causes severe immunological problems. the aims of this study were to isolate a new zen-degrading micro-organism for biological detoxification, to examine its ability to degrade zen in liquid medium, and to evaluate its potential for in vivo preventitive effects against zen (as would occur with contaminated feed)-induced immu ...201323464632
a rapid method of screening lactic acid bacterial strains for conjugated linoleic acid production.a more rapid and simpler method than those currently used was developed to screen conjugated linoleic acid (cla)-producing bacteria isolated from cow milk. the screening of 500 strains was completed in 10 d and the screening efficiency was 10%. one strain resembling a lactobacillus paracasei strain and two resembling l. helveticus strains converted free linoleic acid to total cla ≥85%.201323470735
a comprehensive approach to determine the probiotic potential of human-derived lactobacillus for industrial use.specific strains should only be regarded as probiotics if they fulfill certain safety, technological and functional criteria. the aim of this work was to study, from a comprehensive point of view (in vitro and in vivo tests), three lactobacillus strains (lactobacillus paracasei jp1, lactobacillus rhamnosus 64 and lactobacillus gasseri 37) isolated from feces of local newborns, determining some parameters of technological, biological and functional relevance. all strains were able to adequately g ...201223498174
a description of the lactic acid bacteria microbiota associated with the production of traditional fermented vegetables in vietnam.an important part of the daily nourishment in vietnam constitutes of fermented vegetables. bacteria and especially lactic acid bacteria play a central role in the production of many fermented vegetables. the current study was conducted to investigate the diversity of native lactic acid bacteria (lab) populations in 'dua muoi' (mustard and beet fermentation) and 'ca muoi' (eggplant fermentation), three types of popular traditional fermented vegetables of vietnamese origin. to this end a polyphasi ...201323500611
colonizing the embryonic zebrafish gut with anaerobic bacteria derived from the human gastrointestinal tract.the zebrafish has become increasingly popular for microbiological research. it has been used as an infection model for a variety of pathogens, and is also emerging as a tool for studying interactions between a host and its resident microbial communities. the mouse microbiota has been transplanted into the zebrafish gut, but to our knowledge, there has been no attempt to introduce a bacterial community derived from the human gut. we explored two methods for colonizing the developing gut of 5-day- ...201323530761
characterization of functional, safety, and gut survival related characteristics of lactobacillus strains isolated from farmhouse goat's milk cheeses.a set of 80 lactobacillus strains (36 lactobacillus plantarum and 44 lactobacillus paracasei) isolated from spanish farmhouse cheeses have been studied as to their functional and safety properties and their survival under gut-related conditions. none of these 80 lactobacillus strains were able to hydrolyse starch. a high percentage of l. plantarum and l. paracasei strains were, however, capable of hydrolysing casein (86.1% and 68.2% respectively). for the other characteristics investigated, l. p ...201323558197
effects of three-month intake of synbiotic on inflammation and body composition in the elderly: a pilot study.we hypothesize that improvements in the gut microbiota are capable of ameliorating gut permeability and, consequently, reducing systemic inflammation and the risk of frailty. this study aims to evaluate some effects of synbiotic supplementation on inflammatory markers and the body composition of the elderly at risk of frailty. in a double-blind study that lasted three months, 17 elderly individuals fulfilling one frailty criteria (grip strength) were randomly distributed into two groups: syn (n ...201323595135
detoxification of mycotoxins by probiotic preparation for broiler chickens.biological decontamination of mycotoxins using microorganisms is one of the well known strategies for the management of mycotoxins in foods and feeds. among the different potential decontaminating microorganisms,saccharomyces cerevisiae and lactic acid bacteria represent unique groups, which are widely used in food fermentation and preservation. the aim of this study was to determine the influence of spontaneous fermentation with the use of probiotic bacteria and yeast (lactobacillus paracasei/c ...200623605714
lactobacillus paracasei endocarditis in a consumer of probiotics. 201323622954
effect of probiotics containing lactobacillus paracasei sd1 on salivary mutans streptococci and lactobacilli in orthodontic cleft patients: a double-blinded, randomized, placebo-controlled study.objective : (1) to investigate the effect of probiotic bacterium lactobacillus paracasei sd1 on the level of salivary mutans streptococci and lactobacilli, and (2) the oral persistence of l. paracasei sd1 in orthodontically treated nonsyndromic cleft lip and palate patients. design : double-blinded, randomized, placebo-controlled study. participants : a total of 30 orthodontically treated nonsyndromic cleft lip and palate patients (aged 19.22 ± 3.66 years): 15 in the intervention group (a) and 1 ...201423656594
the efficacy of gaseous ozone on some cariogenic bacteria.the aim of this study is to analyze ozone impact on some cariogenic bacteria in ex vivo and in vitro conditions. the in vitro part of study inoculated dentine with strains of streptococcus mutans atcc 33402 and lactobacillus paracasei atcc 11974 bacteria. samples of dentine before and after 40s ozone treatment were collected and anaerobically incubated. samples of cariogenic dentine (n = 24) were collected from permanent molars within the ex vivo segment of the study, prior and after 40s ozone t ...201323697258
technological and safety properties of lactic acid bacteria isolated from spanish dry-cured sausages.technological and safety-related properties were analyzed in lactic acid bacteria isolated from spanish dry-cured sausages in order to select them as starter cultures. in relation to technological properties, all the strains showed significative nitrate reductase activity; lactobacillus plantarum, lactobacillus paracasei and 52% of the enterococcus faecium strains showed lipolytic activity and only lactobacillus sakei strains (43%) were able to form biofilms. related to safety aspects, e. faeciu ...201323743032
elevated cytokine responses to vibrio harveyi infection in the japanese pufferfish (takifugu rubripes) treated with lactobacillus paracasei spp. paracasei (06tca22) isolated from the mongolian dairy product.with the aim of evaluating the effect of a mongolian dairy product derived lactobacillus paracasei spp. paracasei (strain 06tca22) (lpp) on the cytokine-mediated immune responses to vibrio harveyi infection, we examined 16 cytokine expressions in the japanese pufferfish, takifugu rubripes. fish were orally treated with the heat-killed lpp at 1 mg g(-1) body weight d(-1) for 3 days. at 24 h posttreatment, fish were infected by an intramuscular injection of 0.1 ml v. harveyi bacterial suspension ( ...201323769874
bacillus subtilis natto: a non-toxic source of poly-γ-glutamic acid that could be used as a cryoprotectant for probiotic bacteria.it is common practice to freeze dry probiotic bacteria to improve their shelf life. however, the freeze drying process itself can be detrimental to their viability. the viability of probiotics could be maintained if they are administered within a microbially produced biodegradable polymer - poly-γ-glutamic acid (γ-pga) - matrix. although the antifreeze activity of γ-pga is well known, it has not been used for maintaining the viability of probiotic bacteria during freeze drying. the aim of this s ...201323829836
early intervention with probiotic lactobacillus paracasei f19 has no long-term effect on caries experience.the aim of the study was to evaluate possible long-term effects of a cereal diet supplemented with lactobacillus paracasei f19 (lf19) during weaning on caries experience, mutans streptococci (ms) and lactobacilli (lbc) in a group of 9-year-old children. a secondary aim was to evaluate if the intervention resulted in the permanent integration of lf19 as part of the oral microbiota. the study followed up on a double-blind placebo-controlled randomised trial. among 179 infants that were randomised ...201323838478
dynamics and rrna transcriptional activity of lactococci and lactobacilli during cheddar cheese ripening.cheddar cheese is a complex ecosystem where both the bacterial population and the cheese making process contribute to flavor and texture development. the aim of this study was to use molecular methods to evaluate the impact of milk heat treatment and ripening temperature on starter lactococci and non-starter lactic acid bacteria (nslab) throughout ripening of cheddar cheese. eight cheddar cheese batches were manufactured (four with thermized and four with pasteurized milk) and ripened at 4, 7 an ...201323850855
a review on traditional turkish fermented non-alcoholic beverages: microbiota, fermentation process and quality characteristics.shalgam juice, hardaliye, boza, ayran (yoghurt drink) and kefir are the most known traditional turkish fermented non-alcoholic beverages. the first three are obtained from vegetables, fruits and cereals, and the last two ones are made of milk. shalgam juice, hardaliye and ayran are produced by lactic acid fermentation. their microbiota is mainly composed of lactic acid bacteria (lab). lactobacillus plantarum, lactobacillus brevis and lactobacillus paracasei subsp. paracasei in shalgam fermentati ...201323859403
cytokine mediated immune responses in the japanese pufferfish (takifugu rubripes) administered with heat-killed lactobacillus paracasei spp. paracasei (06tca22) isolated from the mongolian dairy product.the important role played by cytokines in host innate immunity and the interaction of subsets of immune and inflammatory cells through cytokines offer avenues for immune interventions. we investigated 16 cytokine gene responses in the japanese pufferfish, takifugu rubripes orally treated with a heat-killed lactic acid bacterium (lab), lactobacillus paracasei spp. paracasei (strain 06tca22) (lpp) isolated from a mongolian dairy product at 1mgg(-1)body weightd(-1) for 3days. additionally, we asses ...201323867289
lactobacillus paracasei sd1, a novel probiotic, reduces mutans streptococci in human volunteers: a randomized placebo-controlled trial.the present study investigates the effect of an oral lactobacillus paracasei sd1 isolate on a number of salivary mutans streptococci, lactobacilli, and yeasts and to examine whether the strain could persist in the oral cavity after a short period of consumption. the potential side effect of the probiotic was also evaluated.201423892501
lactobacillus paracasei comparative genomics: towards species pan-genome definition and exploitation of diversity.lactobacillus paracasei is a member of the normal human and animal gut microbiota and is used extensively in the food industry in starter cultures for dairy products or as probiotics. with the development of low-cost, high-throughput sequencing techniques it has become feasible to sequence many different strains of one species and to determine its "pan-genome". we have sequenced the genomes of 34 different l. paracasei strains, and performed a comparative genomics analysis. we analysed genome sy ...201323894338
probiotics in primary prevention of allergic disease--follow-up at 8-9 years of age.long-term effects of probiotics in primary prevention of allergic disease need further evaluation. we previously reported a reduced cumulative incidence of infant eczema by feeding lactobacillus paracasei ssp paracasei f19 (lf19) during weaning. therefore, we assessed effects of lf19 on the prevalence of allergic disease at school age.201323895631
production of l- and d-lactic acid from waste curcuma longa biomass through simultaneous saccharification and cofermentation.simultaneous saccharification and cofermentation (sscf) of curcuma longa waste biomass obtained after turmeric extraction to l- and d-lactic acid by lactobacillus coryniformis and lactobacillus paracasei, respectively, was investigated. this is a rich, starchy, agro-industrial waste with potential for use in industrial applications. after optimizing the fermentation of the biomass by adjusting nitrogen sources, enzyme compositions, nitrogen concentrations, and raw material concentrations, the ss ...201323911815
short communication: influence of long-chain inulin and lactobacillus paracasei subspecies paracasei on the sensory profile and acceptance of a traditional yogurt.the objectives of this study were to evaluate the influence of the addition of long-chain inulin as a fat replacer and prebiotic agent (20g/l) and (or) probiotic lactobacillus paracasei ssp. paracasei on the sensory profile and acceptance of yogurts, and to assess the influence of descriptive attributes on the sensory acceptance of the products. the addition of inulin to low-fat yogurt improved its brightness and firmness, which was similar to the full-fat yogurt. however, the use of long-chain ...201323932139
long-term treatment with probiotics in primary care patients with irritable bowel syndrome--a randomised, double-blind, placebo controlled trial.objective. meta-analyses have indicated effect of probiotics on irritable bowel syndrome (ibs). however, few long-term trials have been conducted and uncertainty remains as to effectiveness and long-term effect in a primary care setting. we aimed to investigate the effect of probiotics compared with placebo in the management of ibs in primary care during a 6-month treatment period and with a 6-month follow-up. material and methods. we randomized ibs patients fulfilling rome iii criteria to recei ...201323957590
diversity and dynamic of lactic acid bacteria strains during aging of a long ripened hard cheese produced from raw milk and undefined natural starter.the aim of this study was to explore diversity and dynamic of indigenous lab strains associated with a long ripened hard cheese produced from raw milk and undefined natural starter such as pdo grana padano cheese. samples of milk, curd, natural whey culture and cheeses (2nd, 6th, 9th and 13th months of ripening) were collected from 6 cheese factories in northern italy. dna was extracted from each sample and from 194 lab isolates. trna(ala)-23s rdna-rflp was applied to identify isolates. strain d ...201324010599
quantitative pcr for the specific quantification of lactococcus lactis and lactobacillus paracasei and its interest for lactococcus lactis in cheese samples.the first objective of this work was to develop real-time quantitative pcr (qpcr) assays to quantify two species of mesophilic lactic acid bacteria technologically active in food fermentation, including cheese making: lactococcus lactis and lactobacillus paracasei. the second objective was to compare qpcr and plate counts of these two species in cheese samples. newly designed primers efficiently amplified a region of the tuf gene from the target species. sixty-three dna samples from twenty diffe ...201324010609
application of culture-dependent and culture-independent methods for the identification of lactobacillus kefiranofaciens in microbial consortia present in kefir grains.the biological and technological characteristics of kefiran as well as its importance in grain integrity led us to analyze the microbial kefir grain consortium with focus on lactobacillus kefiranofaciens. the presence of l. kefiranofaciens in the nine kefir grains studied was demonstrated by denaturing gradient gel electrophoresis. by culture dependent methods applying a methodology focused on the search of this species, 22 isolates with typical morphology were obtained and identified applying a ...201324010614
brazilian kefir: structure, microbial communities and chemical composition.microbial ecology and chemical composition of brazilian kefir beverage was performed. the microorganisms associated with brazilian kefir were investigated using a combination of phenotypic and genotypic methods. a total of 359 microbial isolates were identified. lactic acid bacteria (60.5%) were the major isolated group identified, followed by yeasts (30.6%) and acetic acid bacteria (8.9%). lactobacillus paracasei (89 isolates), lactobacillus parabuchneri (41 isolates), lactobacillus casei (32 i ...201124031681
comparison of innate immune activation after prolonged feeding of milk fermented with three species of lactobacilli.the present investigation aimed at identifying the abilities of three different species of probiotic lactobacilli to modulate cellular immune responses in mouse neutrophils and macrophages in vivo over a study period of 60 days. neutrophil respiratory burst enzymes (cytochrome c reductase and mpo) showed remarkable increased activity (p ≤ 0.01) after consumption of milks fermented by different species of probiotics over 30 and 60 days of feeding trials. enzyme activities (β-galactosidase and β-g ...201324033444
lactobacillus paracasei subsp. paracasei f19 in bell's stage 2 of necrotizing enterocolitis.the aim of this trial is to evaluate the role lactobacillus paracasei in bell's stage 2 in order to prevent the clinical progression to stage 3.201324051968
evaluation of bean and soy tempeh influence on intestinal bacteria and estimation of antibacterial properties of bean tempeh.in this study the effect of bean tempeh on the growth of bacillus subtilis, escherichia coli, lactobacillus acidophilus and lactobacillus paracasei bacteria was investigated. antibacterial activity was observed only in relation to the bacteria bacillus subtilis. the effect of tempeh products on human intestinal microflora was also assessed. bean and soy tempeh were culinarily processed and next digested in conditions simulating the human digestive tract (one of the digestive tracts was equipped ...201324053022
feeding probiotic lactobacillus paracasei to ossabaw pigs on a high-fat diet prevents cholesteryl-ester accumulation and lps modulation of the liver x receptor and inflammatory axis in alveolar macrophages.liver x receptors (lxr) play an integral role in cholesterol metabolism and the inflammatory response. high-fat (hf) diets and microbial infection can antagonize the lxr pathway leading to accumulation of cholesteryl-esters (ce) and increased expression of pro-inflammatory mediators in macrophages. the probiotic bacteria lactobacillus paracasei possesses cholesterol lowering and immune modulating properties. therefore, the present study sought to model whether daily feeding of l. paracasei to ju ...201324060267
role of probiotics in the prevention and treatment of meticillin-resistant staphylococcus aureus infections.meticillin-resistant staphylococcus aureus (mrsa) is a multidrug-resistant micro-organism and is the principal nosocomial pathogen worldwide. following initial in vitro experiments demonstrating that lactobacillus acidophilus cl1285(®) and lactobacillus casei lbc80r(®) commercial strains exhibit antibacterial activity against clinical mrsa isolates, we conducted a literature search to find any evidence of probiotic efficacy in decolonisation or treatment of s. aureus infection. as summarised bel ...201324071026
complete genome sequence of the probiotic strain lactobacillus casei (formerly lactobacillus paracasei) lock919.lactobacillus casei is usually regarded as a bacterium that lives naturally in the human intestinal tract, where it can contribute to host health and well-being. we describe here the complete genome sequence of l. casei lock919, a strain with probiotic properties isolated from child feces. the genome consists of a 3.11-mb chromosome and a 29,768-bp plasmid.201324072862
effect of a sublethal high-pressure homogenization treatment on the fatty acid membrane composition of probiotic lactobacilli.high-pressure homogenization (hph) has been proposed to be applied directly to lactic acid bacterial cells at sublethal levels to enhance some functional properties. as the principal target of hph are the cell surface envelope structures, the aim of this work was to study the effect of a hph treatment, applied at 50 mpa, on cell membrane stress responses of already-known functional strains, isolated from argentinean products. specifically, the membrane fatty acid composition of cells before and ...201424111720
a zn-dependent metallopeptidase is responsible for sensitivity to lsbb, a class ii leaderless bacteriocin of lactococcus lactis subsp. lactis bgmn1-5.lactococcus lactis subsp. lactis bgmn1-5 produces a leaderless class ii bacteriocin called lsbb. to identify the receptor for lsbb, a cosmid library of the lsbb-sensitive strain bgmn1-596 was constructed. about 150 cosmid clones were individually isolated and transferred to lsbb-resistant mutants of bgmn1-596. cosmid pazilcos/mn2, carrying a 40-kb insert, was found to restore lsbb sensitivity in lsbb-resistant mutants. further subcloning revealed that a 1.9-kb fragment, containing only one open ...201324123824
molecular analysis and clinical significance of lactobacillus spp. recovered from clinical specimens presumptively associated with disease.lactobacillus spp. are part of the normal human flora and are generally assumed to be nonpathogenic. we determined the genotypic identification of >100 lactobacillus isolates from clinical specimens in the context of presumed pathogenic potential (e.g., recovered as the single/predominant isolate from a sterile site or at ≥10(5) cfu/ml from urine). this study assessed the clinical significance and the frequency of occurrence of each lactobacillus sp. we identified 16 species of lactobacillus by ...201424131686
effect of buckwheat flour and oat bran on growth and cell viability of the probiotic strains lactobacillus rhamnosus imc 501®, lactobacillus paracasei imc 502® and their combination synbio®, in synbiotic fermented milk.fermented foods have a great significance since they provide and preserve large quantities of nutritious foods in a wide diversity of flavors, aromas and texture, which enrich the human diet. originally fermented milks were developed as a means of preserving nutrients and are the most representatives of the category. the first aim of this study was to screen the effect of buckwheat flour and oat bran as prebiotics on the production of probiotic fiber-enriched fermented milks, by investigating th ...201324140807
safety evaluation of lactobacillus paracasei subsp. paracasei lc-01, a probiotic bacterium.the safety of lactobacillus paracasei subsp. paracasei lc-01 was evaluated for its use as a potential probiotic. in our in vitro study, the antibiotic resistance and the ability to produce biogenic amine were determined. the results showed that the strain was sensitive to all tested antibiotics and did not produce biogenic amine except for tyramine. the oral toxicity of this strain was evaluated in balb/c mice. one hundred mice were divided into 10 groups. four groups were administered 0, 10(8), ...201324173643
safety and immunomodulatory effects of three probiotic strains isolated from the feces of breast-fed infants in healthy adults: setoprob study.we previously described the isolation and characterization of three probiotic strains from the feces of exclusively breast-fed newborn infants: lactobacillus paracasei cncm i-4034, bifidobacterium breve cncm i-4035 and lactobacillus rhamnosus cncm i-4036. these strains were shown to adhere to intestinal mucus in vitro, to be sensitive to antibiotics and to resist biliary salts and low ph. in the present study, a multicenter, randomized, double-blind, placebo-controlled trial with 100 healthy vol ...201324205115
bioprotection of ready-to-eat probiotic artichokes processed with lactobacillus paracasei lmgp22043 against foodborne pathogens.the survival of 3 pathogens listeria monocytogenes atcc19115, salmonella enterica subsp. enterica atcc13311, and escherichia coli atcc8739 was evaluated over time in ready-to-eat (rte) artichoke products processed or not with the probiotic strain lactobacillus paracasei lmgp22043. both probiotic and standard products (final ph about 4.0; aw = 0.98) dressed with oil and packaged in modified atmosphere were inoculated with pathogens at a level of about 3 log cfu/g and stored at 4 ºc for 45 d. path ...201324245894
evaluation of the effect of lactobacillus paracasei (hf.a00232) in children (6-13 years old) with perennial allergic rhinitis: a 12-week, double-blind, randomized, placebo-controlled study.dietary supplementation with probiotics alters intestinal microflora of children and may have immunomodulatory effects in prevention of allergic diseases. the aim of this study was to evaluate the effects of lactobacillus paracasei (lp), strain hf.a00232, as a supplementary agent to levocetirizine in treating children with perennial allergic rhinitis (ar).201424269033
lactobacillus paracasei dsmz16671 reduces mutans streptococci: a short-term pilot study.reducing the burden of pathogenic mutans streptococci is a goal of oral health. lactobacillus paracasei dsmz16671, even after heat-killing, specifically co-aggregates mutans streptococci in vitro and retains this activity in human saliva. in rats, it reduces mutans streptococcal colonization of teeth and caries scores. this pilot study sought to assess the potential of heat-killed l. paracasei dsmz16671 (pro-t-action(®)) to reduce levels of salivary mutans streptococci in humans, using sugar-fre ...201324273614
tailoring the probiotic potential of non-starter lactobacillus strains from ripened parmigiano reggiano cheese by in vitro screening and principal component analysis.non-starter lactic acid bacteria (nslab) inhabiting fermented food have been recently revised as source of probiotic strains. here, we in vitro assessed the potential probiotic aptitude of a de-replicated set of nslab previously isolated from long ripened parmigiano reggiano cheeses (22 lactobacillus rhamnosus, 18 lactobacillus paracasei, 3 lactobacillus casei, 2 lactobacillus harbinensis, and 2 lactobacillus fermentum). most strains showed moderate to good resistance to biological barriers, inc ...201424290648
probiotics reduce symptoms of antibiotic use in a hospital setting: a randomized dose response study.probiotics are known to reduce antibiotic associated diarrhea (aad) and clostridium difficile associated diarrhea (cdad) risk in a strain-specific manner. the aim of this study was to determine the dose-response effect of a four strain probiotic combination (howaru(®) restore) on the incidence of aad and cdad and severity of gastrointestinal symptoms in adult in-patients requiring antibiotic therapy. patients (n=503) were randomized among three study groups: howaru(®) restore probiotic 1.70×10(1 ...201424291194
effects of a lactobacillus paracasei b21060 based synbiotic on steatosis, insulin signaling and toll-like receptor expression in rats fed a high-fat diet.insulin resistance (ir) has been identified as crucial pathophysiological factor in the development and progression of non-alcoholic fatty liver disease (nafld). although mounting evidence suggests that perturbation of gut microflora exacerbates the severity of chronic liver diseases, therapeutic approaches using synbiotic has remained overlooked. here, we show that a synbiotic composed by lactobacillus paracasei b21060 plus arabinogalactan and fructo-oligosaccharides lessens nafld progression i ...201424314869
randomised double-blind placebo-controlled study of the effect of lactobacillus paracasei ncc 2461 on skin reactivity.in recent decades, the prevalence of subjects with reactive skin has considerably increased in industrialised countries. 50% of women and 30% of men report cutaneous discomfort classified under reactive/sensitive skin. several topical approaches have been proposed, in particular through improvement of galenic forms or protection of epidermal surface. we propose to act differently, deeply from inside the body via an innovative nutritional approach. to this purpose, lactobacillus paracasei ncc 246 ...201424322879
immune modulation property of lactobacillus paracasei ncc2461 (st11) strain and impact on skin defences.the gut intestinal tract harbours a complex microbiota. disturbances in the microbiota composition have been associated with several immune dysfunctions such as inflammatory diseases. specific strains of probiotics have shown to beneficially influence the composition and/or metabolic activity of the endogenous microbiota. taking advantage of the plasticity of the immune system, the probiotic strain ncc2461 (i.e. st11 or cncm i-2116) supports and/or restores homeostasis in reaction to different p ...201424322880
[identification of lactic acid bacteria in commercial yogurt and their antibiotic resistance].to identify lactic acid bacteria (lab) in commercial yogurts and investigate their antibiotic resistance.201324341282
high-fat diet-induced obesity is attenuated by probiotic strain lactobacillus paracasei st11 (ncc2461) in rats.in a recent study, we obtained some evidences that probiotic strain lactobacillus affects the autonomic nerve activities and regulates blood glucose and cardiovascular function. in the study presented here, we found that long-term ingestion of the lactobacillus strain lactobacillus paracasei st11 (ncc2461) reduced body weight and abdominal fat weight. to investigate possible role of autonomic nerves in anti-obesity action of ncc2461, we examined the effects of intraduodenal (id) injection of the ...200824351773
effect of exogenous factors on bacteriocin production from lactobacillus paracasei j23 by using a resting cell system.a resting cell system was developed for bacteriocin lac-b23 production from lactobacillus paracasei j23. the resting cell medium contained (g/l): glucose 20, sodium acetate 5.0, mnso4 0.25 mgso4 0.5, ammoniumhydrogencitrate 1.0, kh2po4 1.0. the resting cell incubation time and temperature were 20 h and 37 °c and the effects of exogenous factors, including amino acids, glycerol, pyruvic acid, and α-ketoglutaric acid were investigated. cys and gly could stimulate the production of bacteriocin, whi ...201324351821
lactobacillus paracasei subsp. paracasei lc01 positively modulates intestinal microflora in healthy young adults.lactobacillus paracasei subsp. paracasei lc01 (lc01) can tolerate intestinal stresses and has antioxidant activity. to evaluate the effect of the bacterium on human intestinal microflora, a randomized, double-blind, placebo-controlled human trial was carried out. fifty-two healthy adult volunteers were randomized equally to two groups. one group consumed 12% (wt/vol) skimmed milk supplemented with 10(10) cfu of lc01 each day for the 4-week treatment period, and then consumed placebo in the next ...201324385355
comparison of two oral probiotic preparations in a randomized crossover trial highlights a potentially beneficial effect of lactobacillus paracasei ncc2461 in patients with allergic rhinitis.there is promising but conflicting evidence to recommend the addition of probiotics to foods for prevention and treatment of allergy. based on previous studies with fermented milk containing lactobacillus paracasei ncc2461, we aimed to compare the effect of a powder form of the latter probiotic with the effect of a blend of lactobacillus acidophilus atcc sd5221 and bifidobacterium lactis atcc sd5219 in patients with allergic rhinitis.201424393277
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