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a protective protein antigen of rickettsia rickettsii has tandemly repeated, near-identical sequences.the nucleotide sequence of a rickettsia rickettsii gene that encodes a high-molecular-mass surface antigen (190 kilodaltons), which elicits protective immunity, was determined. the 6,747-nucleotide gene coded for a 2,249-amino-acid protein with a calculated molecular weight of 224,321. a 3.8-kilobase psti fragment proximal to the 5' end of the gene was found to consist of 13 highly related tandem repeats which constituted over 40% of the coding region. the repeated sequences could be divided int ...19902117568
hispid cotton rats (sigmodon hispidus) as a source for infecting immature dermacentor variabilis (acari: ixodidae) with rickettsia rickettsii.hispid cotton rats (sigmodon hispidus say and ord) were susceptible to infection with rickettsia rickettsii wolbach under laboratory conditions and were capable of serving as sources for infecting ticks with rickettsiae. cotton rats developed rickettsemias that could be detected for as long as 6 h following intraperitoneal inoculation of 10(5) plaque-forming units (pfus) of r. rickettsii (morgan strain). an estimate of the median infectious dose (id50) was made by inoculating six groups (eight a ...19902117665
[spotted fever group rickettsiosis on awaji island, japan].three cases of spotted fever group rickettsiosis occurring on awaji island, hyogo prefecture, the first reported in the kinki district, are described. the illness appeared from august to september in 1988. high-grade fever and papular erythema were observed in all cases. eschar, lymphadenopathy and hepatomegaly were observed in two-thirds of the cases, respectively. the antibody titers for proteus ox-2 by the weil-felix reaction were elevated, and immunofluorescence test with r. rickettsii of th ...19902119406
nucleotide sequence of the p34 gene from rickettsia rickettsii. 19902124682
reduction of drug accumulation and dna topoisomerase ii activity in acquired teniposide-resistant human cancer kb cell lines.we have isolated stable teniposide (vm26)-resistant cell lines from human cancer kb cells by stepwise exposure to increasing doses of the drug. at each step, we have purified vm26-resistant cell lines. kb/vm-a, kb/vm-b, kb/vm-1, kb/vm-2, kb/vm-3, and kb/vm-4 showed 3-, 6-, 12-, 16-, 74-, and 95-fold higher resistance to vm26 than did kb. we have further characterized kb/vm-2 and kb/vm-4 which showed about 15- and 100-fold higher resistance to vm26 or etoposide (vp16) than did kb. both vm26-resis ...19902168282
morphological aspects of inhibition of transformation of rat kidney cells infected with a temperature-sensitive mutant of the rous sarcoma virus by rat fibroblast interferon.normal rat kidney cells (nrk) infected with a temperature-sensitive (ts) mutant of rous sarcoma virus (rsv) at the permissive temperature (33 degrees c) exhibit the morphological and growth characteristics of the transformed state. by the use of this system, it has been shown that the addition of rat fibroblast interferon to infected cells grown at a nonpermissive temperature (38 degrees c) prevents re-transformation when they are introduced to the permissive temperature. merely treating cells a ...19902168311
diagnosis of human ehrlichiosis with the indirect fluorescent antibody test: kinetics and specificity.human ehrlichiosis, an acute febrile illness caused by ehrlichia canis or a closely related rickettsial organism, was first identified in 1986. from 1986 through 1988, sera from 85 patients demonstrated a fourfold rise or fall in antibody titer to e. canis. seven (22%) of 32 patients initially tested during the first week after onset of illness. 17 (68%) of 25 tested during the second week, and all 18 tested during the third week had titers that exceeded the minimum positive titer of greater tha ...19902192013
partitioning of nucleoids. 19902194249
hip surgery in adults. 20082223439
shoulder surgery. 20072223442
shoulder surgery. 20072223442
[nmr-microscopic studies of the condylar cartilage of the temporomandibular joint].the objectifying of growth mechanisms of the tmj is very important for orthodontic diagnosis, treatment as well as clinical research. condylar cartilage of the tmj from neonatal pigs was investigated on in vivo preparations by nmr-microscopy. nmr-micro-pictures and histologic slide preparations of condylar cartilage were compared and discussed in connection with its implications for treatment with functional appliances.19902227743
[psychological stress at work and health status of medical personnel]. 20082267842
immunization of cattle (bos indicus x bos taurus) against hyalomma anatolicum anatolicum using antigens derived from tick salivary gland extracts.studies were conducted on 41 cross-bred (bos taurus x bos indicus) calves which were less than 1 year old. three types of salivary gland antigens (sg ag) viz. sg ag-i (whole), sg ag-ii (supernatant) and sg ag-iii (sediment), prepared from the ixodid tick, hyalomma anatolicum anatolicum, were used for immunizing these calves. the calves were divided into five groups. the first three groups were immunized with sg ag-i, -ii and -iii with freund's complete adjuvant (fca), respectively. the fourth gr ...19902276870
intrathoracic lymphadenopathy. a rare manifestation of rheumatoid pulmonary disease.this is the first antemortem report of a patient with long-standing ra and interstitial lung disease who developed reactive mediastinal adenopathy coincident with increases in the activity of his interstitial process. mediastinal adenopathy was discovered by means of ct of the chest as part of an evaluation of interstitial lung disease. the increasing use of better imaging techniques for this purpose will undoubtedly reveal more patients with this finding. mediastinal lymphadenopathy complicatin ...20072323235
ca2+ transients are not required as signals for long-term neurite outgrowth from cultured sympathetic neurons.a method for clamping cytosolic free ca2+ ([ca2+]i) in cultures of rat sympathetic neurons at or below resting levels for several days was devised to determine whether ca2+ signals are required for neurite outgrowth from neurons that depend on nerve growth factor (ngf) for their growth and survival. to control [ca2+]i, normal ca2+ influx was eliminated by titration of extracellular ca2+ with egta and reinstated through voltage-sensitive ca2+ channels. the rate of neurite outgrowth and the number ...19902324199
nucleotide sequence of porcine insulin-like growth factor. 1:5' untranslated region, exons 1 and 2 and mrna. 19902326169
cinnamon oil abuse by adolescents.reports in the literature about cinnamon oil toxicity are limited to allergic reactions and local irritant effects from dermatologic exposure. cinnamon oil is easily obtained from pharmacies in 5-10 ml amounts for use as a flavoring agent and in craft items. within a 5-mo period the pittsburgh poison center (ppc) documented 32 cases of cinnamon oil abuse; all cases involved males aged 11-16 y and were reported to the ppc by school nurses. sucking on toothpicks or fingers which had been dipped in ...19902327068
[flexible arrangement of working time in the field of nursing--a contribution to optimal care]. 20082329782
lipid soluble antioxidants preserve rabbit corneal cell function.the survival time of rabbit corneal endothelial cells in isolated perfused cornea is extended dramatically by the addition of oxygen free radical scavengers. lipid soluble antioxidants were found to be more effective than water soluble non-enzymatic antioxidants in extending the survival time. the ultrastructural appearance of endothelial cells treated with vitamin e was compared with controls. vitamin e treated endothelial cells retained normal appearance up to 12h, but without vitamin e, break ...19902335108
cloning and nucleotide sequence of a cdna encoding the antifungal-protein of aspergillus giganteus and preliminary characterization of the native gene. 19902374718
diagnosis of acute typhus infection using the polymerase chain reaction.we used the polymerase chain reaction (pcr) for the diagnosis of an acute rickettsial infection. a primer pair derived from the 17-kda antigen sequence of rickettsia rickettsii amplified specifically a 434-bp dna fragment from the genome of rocky mountain spotted fever and endemic and epidemic typhus. the assay was able to detect as few as 30 rickettsiae. detection of pcr-amplified dna with a digoxigenin-labeled dna probe confirmed an acute human infection with rickettsia prowazekii.19902378469
endotoxin-induced uveitis in the rat: a hypothesis for preferential involvement of the anterior uvea.endotoxin-induced uveitis (eiu) was produced in lewis rats by footpad injection of salmonella endotoxin. protein and cells were measured both in the aqueous humor and in the cerebrospinal fluid (csf) in order to examine if the inflammation was strictly limited to the anterior uvea. eiu was also induced in fischer and brown norway rats and the inflammation was compared among the three strains. although the function and structure of the choroid plexus is very similar to the ciliary body, no signs ...19902384004
computer simulation of rocky mountain spotted fever transmission by the american dog tick (acari: ixodidae).a computer model was developed for simulation of the transmission of rickettsia rickettsii, the causative agent of rocky mountain spotted fever (rmsf), by the american dog tick, dermacentor variabilis (say). the model of rmsf was combined with a model for population dynamics of the american dog tick and included simulation of infection and transmission of rickettsiae between ticks and host mammals and transmission of rmsf to humans. the model simulated the effects of biotic and environmental var ...19902388242
"synaptic" ribbons in the pineal gland of the horse.previous studies on the ultrastructure of the horse pineal gland did not report the presence of "synaptic" ribbons, functionally enigmatic pinealocyte organelles regularly occurring in other mammalian species. the aim of the present study was to reinvestigate the horse pinealocyte in this respect. careful investigations here reported allowed detection of "synaptic" ribbons in the pinealocytes of all the examined animals, although in a relatively low number (5.4 +/- 2.0 per 20,000 microns 2 of pi ...19902395075
use of the megasoft bandage lens for treatment of complications after trabeculectomy.shallow anterior chambers and leaking filtration blebs are possible complications after trabeculectomy that can be treated with therapeutic contact lenses. in most cases, however, treatment fails because these lenses are not large enough to cover the filtering bleb. we evaluated the use of a newly developed large diameter (20.5 mm) therapeutic soft contact lens. five patients with shallow anterior chambers and ten patients with leaking filtering blebs after trabeculectomy were fitted with this n ...20082396651
rat organum vasculosum laminae terminalis in vitro: responses to changes in sodium concentration.extracellular action potentials were recorded from the organum vasculosum laminae terminalis (ovlt) in rat brain slice preparations; the effect of different concentrations of nacl on spontaneous firing frequency was studied. from 72 neurons, 67 (93%) were responsive to various perfusion media, while 5 neurons (7%) were not responsive. the change from the standard medium (sm; 124 mm nacl) to 99 mm, decreased the firing frequency in 24 (65%) and increased it in 13 (35%) out of 37 responsive cells. ...19902397412
reactivity of monoclonal antibodies to rickettsia rickettsii with spotted fever and typhus group rickettsiae.analysis of 15 spotted fever group (sfg) and 2 typhus group strains of rickettsiae with a panel of monoclonal antibodies revealed a number of shared and unique epitopes of the 120- and 155-kilodalton surface proteins. all of the sfg strains but neither of the typhus group strains reacted with antibody to the lipopolysaccharidelike antigen of rickettsia rickettsii; possibly the lipopolysaccharidelike antigen is the common antigen which defines the sfg. north carolina and montana strains of r. ric ...19872432081
mystacial vibrissae representation within the trigeminal sensory nuclei of the cat.somatotopic arrangements of axon terminals of primary afferent fibers innervating follicles of the mystacial vibrissae were examined in the cat by the transganglionic horseradish peroxidase (hrp) method. forty to 60 hours after injecting hrp into a single or a group of vibrissal follicles, transported hrp was visualized by the tetramethylbenzidine technique. hrp-labeled axon terminals were distributed in the ventral subnucleus of the principal sensory trigeminal nucleus (ventral vp), in the oral ...19862432098
neutralizing activity of monoclonal antibodies to heat-sensitive and heat-resistant epitopes of rickettsia rickettsii surface proteins.antiprotein monoclonal antibodies derived from mice inoculated with rickettsia rickettsii heated at 56 degrees c for 15 min are of two types: one is type specific for epitopes denatured by moderate temperatures, and the other is specific for epitopes resistant to 100 degrees c for 5 min. the heat-resistant epitopes are found by immunoblotting on multiple polypeptides after solubilization of the rickettsiae at temperatures of 56 degrees c or higher. most, but not all, antibodies to the heat-sensi ...19872434430
protective monoclonal antibodies recognize heat-labile epitopes on surface proteins of spotted fever group rickettsiae.thirty-eight monoclonal antibodies that have not been reported previously were developed from mice immunized with rickettsia rickettsii, r. conorii, and r. sibirica. western immunoblotting showed that these monoclonal antibodies are directed against heat-sensitive epitopes which are located on two major surface polypeptides with molecular sizes ranging from 115 to 150 kilodaltons. the detection of the two bands did not depend on the presence of 2-mercaptoethanol. both bands were destroyed by tre ...19882458318
characterization of antilipolytic action of polyamines in isolated rat adipocytes.the interactions of polyamines with the lipolytic system were studied in isolated rat adipocytes. spermine, spermidine and putrescine significantly inhibited adenosine deaminase-stimulated lipolysis. an antilipolytic effect of spermine was detectable at a concentration of 0.25 mm (p less than 0.05). at a concentration of 10 mm all three polyamines inhibited the stimulated lipolysis by 50-60% (p less than 0.001). in addition, spermine enhanced the antilipolytic sensitivity of insulin. spermine (1 ...19892476118
hemocyte monophenol oxidase activity in mosquitoes exposed to microfilariae of dirofilaria immitis.monophenol oxidase (mpo) activity in hemocytes collected from aedes aegypti liverpool strain and aedes trivittatus intrathoracically inoculated with saline alone, inoculated with dirofilaria immitis microfilariae (mff), or from uninoculated mosquitoes was compared using a radiometric tyrosine hydroxylation assay. hemocyte mpo activity in mff-inoculated (= immune-activated) mosquitoes was significantly increased at 24 hr postinoculation (pi) in a. aegypti and at 6, 12, and 24 hr pi in a. trivitta ...19892493084
ocular manifestations of rocky mountain spotted fever in dogs.dogs were examined ophthalmoscopically to determine the prevalence and type of ocular lesions associated with naturally acquired rocky mountain spotted fever (rmsf). in a consecutive series of 11 dogs with serologically confirmed rmsf, 9 had ocular involvement reflecting various degrees of vascular damage, including subconjunctival hemorrhage, hyphema, anterior uveitis, iris stromal hemorrhage, retinal petechiae, and focal areas of retinal edema and perivascular inflammatory cell infiltrate. the ...19892494144
identification of rickettsiae in cutaneous biopsy specimens from dogs with experimental rocky mountain spotted fever.direct immunofluorescence reaction for rickettsia rickettsii was performed on formalin-fixed, paraffin-embedded cutaneous biopsy specimens collected from dogs with experimental rocky mountain spotted fever (rmsf). a technique of trypsin digestion of deparaffinized, rehydrated sections was successful in demonstrating discrete, immunofluorescent organisms in endothelia and adjacent vessel walls in the dermis. r rickettsii was identified only in grossly evident dermal lesions (macular rash or oral ...19892494323
production of antibody to and cellular localization of erythrocyte-sensitizing substance from rickettsia rickettsii.antibodies to rickettsia rickettsii erythrocyte-sensitizing substance (ess) were raised in rabbits by using a derivatized ess. the resulting antibodies reacted with r. rickettsii and cross-reacted with rickettsia conorii, a member of the spotted fever group rickettsiae, but did not react with rickettsia typhi, a member of the typhus group rickettsiae, legionella bozemanii, or proteus vulgaris ox19 or ox2. immunoblot analysis indicated that ess was present in more than one fraction and that the m ...19892497137
cross-reaction of immune sera from patients with rickettsial diseases.rickettsia rickettsii and rickettsia conorii are the causative agents of two common and serious diseases, rocky mountain spotted fever and mediterranean spotted fever, respectively. in patients naturally infected with either of these organisms, antibodies are produced which cross-react with antigens of the other so extensively that diagnostic tests usually cannot identify the causative agents. the results of this study indicate that serodiagnostic tests with antigen from one of these two organis ...19892501497
rocky mountain spotted fever: a disease in need of microbiological concern.rocky mountain spotted fever, a life-threatening tick-transmitted infection, is the most prevalent rickettsiosis in the united states. this zoonosis is firmly entrenched in the tick host, which maintains the rickettsiae in nature by transovarian transmission. although the incidence of disease fluctuates in various regions and nationwide, the problems of a deceptively difficult clinical diagnosis and little microbiologic diagnostic effort persist. many empiric antibiotic regimens lack antirickett ...19892504480
infected ticks feeding on persons in areas endemic for lyme disease and rocky mountain spotted fever. 19892507649
probe directed at a segment of rickettsia rickettsii rrna amplified with polymerase chain reaction.in an effort to explore a sensitive taxon-specific detection system for bacteria, we sequenced the 16s rrna from two strains of rickettsia rickettsii, five other rickettsiae, and coxiella burnetti to find a probe site unique to r. rickettsii. we then synthesized a 16-mer that hybridized only to the rrna of r. rickettsii. using a primer complementary to a sequence found only in rickettsial rrna, we then generated a cdna. we amplified the probe site in a 180-base segment of the cdna by using the c ...19892512323
detection of rickettsia rickettsii dna in clinical specimens by using polymerase chain reaction technology.a polymerase chain reaction (pcr) procedure for detecting rickettsial dna was developed and shown to be specific for rickettsia rickettsii and r. conorii, the etiologic agents of rocky mountain spotted fever (rmsf) and boutonneuse fever, respectively. blood clots were obtained from nine confirmed rmsf patients and six controls and analyzed for the presence of rickettsial dna by the pcr method. a defined region of the rickettsial genome was successfully amplified from seven of the nine clinical s ...19892512328
[comparison of in vitro susceptibilities of rickettsia prowazekii, r. rickettsii, r. sibirica and r. tsutsugamushi to antimicrobial agents].the in vitro activities of 16 antimicrobial agents against rickettsia prowazekii (breinl strain), r. rickettsii (bitterroot strain), r. sibirica (atcc no. vr151) and r. tsutsugamushi (gilliam, karp, kato, shimokoshi, kawasaki and kuroki strains) were determined by the cell culture method. tetracycline, demethylchlortetracycline, doxycycline, minocycline, chloramphenicol, kitasamycin and rifampicin were generally effective (mic, 0.005-0.78 micrograms/ml) to all strains tested. quinolones such as ...19892512394
cloning, expression and sequence analysis of the gene encoding the 120 kd surface-exposed protein of rickettsia rickettsii.rickettsia rickettsii (r strain) genomic dna was partially digested and cloned into the lambda expression vector gt11 generating a genomic clone bank. transformant plaques were screened with antisera generated against the 120 kilodalton protein of r. rickettsii to detect those phage expressing the recombinant protein. the gene encoding the 120 kd protein was localized to a 4.3 kilobase sphi-bamhi fragment from the recombinant phage and subcloned into puc18 and puc19. full-length expression of th ...19892515418
in vitro susceptibilities of rickettsia rickettsii and rickettsia conorii to roxithromycin and pristinamycin.in vitro susceptibilities of rickettsia rickettsii and rickettsia conorii to roxithromycin, pristinamycin, and the pristinamycin compounds, p1 and p2, were determined by a dye uptake assay and a plaque assay. the mics were 1 microgram/ml for roxithromycin, 2 micrograms/ml for pristinamycin, greater than 256 micrograms/ml for p1, and 2 micrograms/ml for p2. compounds p1 and p2 did not share synergetic activity. the toxicity of each compound was determined by a dye uptake assay. toxic concentratio ...19892515795
comparison of antigenic reactivity between intracellular and extracellular rickettsiae of spotted fever group.antigens of intracellular rickettsiae in vero cells persistently infected with japanese yh strain of the spotted fever group (rickettsia japonica sp. nov.) reacted in the immunofluorescence test with sera from patients to the same extent by igg antibody titration as did antigens of extracellular rickettsiae prepared from culture fluid of lytically infected bhk cells. on the other hand, igm antibody titers measured with intracellular rickettsiae in vero cells were significantly higher in some cas ...19892516664
a serological survey of ehrlichia canis, ehrlichia equi, rickettsia rickettsii, and borrelia burgdorferi in dogs in oklahoma.serum samples from 259 dogs were tested for antibodies to ehrlichia canis, ehrlichia equi, rickettsia rickettsii, and borrelia burgdorferi using the indirect fluorescent antibody test. the sera were obtained from submissions to the oklahoma animal disease diagnostic laboratory during a 14-month period from june 1986 through july 1987. the rate for positive antibody titers to e. canis was 53%, to e. equi was 33%, to r. rickettsii was 38%, and to b. burgdorferi was 18%. higher percentages of sera ...19892518693
results of pharmacokinetic studies with de-noltab. 20082518856
bites and stings. part 2. bees and vespids. 20082519523
mechanisms and kinetics for platelet and neutrophil localization in immune complex nephritis.we have previously reported that both neutrophils (pmns) and platelets mediate proteinuria in a model of subendothelial immune complex (ic) nephritis (gn) in the rat. in order to understand the interaction of pmns and platelets in this model, we quantitated the uptake of 111in-labelled platelets in glomeruli and correlated this with the number of pmns observed histologically at 10 and 30 minutes, 1, 4 and 24 hours following induction of gn. platelet accumulation was biphasic with a major peak at ...19892533296
effects of trh on the immune system of newborn rats. 19892561202
metabolic changes in glutathione and metallothionein in newborn rat liver.metallothionein (mt) and glutathione (gsh) both contain 30% cysteine and they have distinct developmental profiles in perinatal rat liver. the metabolic relationships between these two cysteine pools were investigated in newborn rats under various experimental conditions. injection of 2-day-old rat pups with buthionine sulfoximine, phorone or diethylmaleate decreased hepatic gsh levels without any change in high basal levels of mt or zinc. similarly injection of l-oxothiazolidine carboxylate inc ...19892566683
prognostic indicators in head and neck cancer patients receiving combined therapy.in 1983 we initiated a prospective nonrandomized study of the value of preoperative chemotherapy in previously untreated patients with stages iii and iv squamous cell carcinoma of the head and neck. in 1983 and 1984, 50 patients were entered in the study. prior to therapy all patients were evaluated by a representative from the medical oncology, radiation therapy, and head and neck surgery divisions, university of utah school of medicine, salt lake city. in addition to the standard preoperative ...20082573381
[ki-1 large cell lymphoma with secondary xanthomatous infiltration of the lesions by chemotherapy]. 20082575882
[entomologic situation regarding arbovirus circulation in the guajaibon area].the collections of culicidae made in the guajaibón area, north coast of havana province, are analyzed with arbovirologic purposes. the predominance of aedes scapularis in the human bait collections is confirmed. the possibility of arbovirus circulation in the area is suggested.19892577010
copper(i)-bleomycin: structurally unique complex that mediates oxidative dna strand scission.copper(i)-bleomycin [cu(i) x blm] was characterized in detail by 13c and 1h nmr. unequivocal chemical shift assignments for cu(i) x blm and cu(i) x blm x co were made by two-dimensional 1h-13c correlated spectroscopy and by utilizing the observation that cu(i) x blm was in rapid equilibrium with cu(i) and metal-free bleomycin, such that individual resonances in the spectra of blm and cu(i) x blm could be correlated. the binding of cu(i) by bleomycin involves the beta-aminoalaninamide and pyrimid ...20082581602
some trematodes of freshwater fishes from north vietnam with a list of recorded endohelminths by fish hosts.the present paper comprises a systematic survey of trematodes collected from 12 species of freshwater fishes from north vietnam (the red river near hanoi). altogether 16 trematode species (14 adults and 2 juvenile forms) have been recorded. these include: amurotrema dombrowskajae, platycladorchis microacetabularis, p. macroacetabularis, neocladorchis multilobularis, carassotrema koreanum, azygia hwangtsiyui, phyllodistomum clariasi, phyllodistomum sp., orientocreadium batrachoides, masenia colla ...19892583614
pretest expectancies and cognitive impairment in alcoholics.alcoholics' neurological deficits have been attributed to cognitive impairment associated with brain dysfunction. because alcoholics perceive themselves as impaired in higher cognitive functions, we investigated the alternative hypothesis that their deficits are predicted by lowered expectancies for successful performance. ss were 48 male, middle-aged veterans administration inpatient alcoholics and 36 community controls. subjects completed a standard series of neuropsychological tests. before t ...20082600240
infection prevention by selective decontamination in intensive care. 20082600283
surgical treatment of the iliotibial band friction syndrome.a selected group of 23 patients underwent surgery for iliotibial band friction syndrome. among the patients presenting with this exertional pain syndrome were runners, football players, and cyclists. diagnosis was clinical since radiographs were negative and an ultrasound examination was positive in only one case, showing an aberrant picture around the lateral femoral epicondyle. although conservative treatment is effective in most cases, an alternative is needed for patients with complaints tha ...20082610280
a reappraisal of the terverticillate penicillia using biochemical, physiological and morphological features. i. numerical taxonomy.three-hundred-and-forty-eight strains representing the major species of terverticillate penicillia, and including representatives of other closely and distantly related species, were included in a numerical taxonomic study. one-hundred characters were derived from morphological features, physiological and biochemical activities and sem micrographs. strains were compared by both gower's coefficient and pattern difference, and clustered using the average linkage algorithm. thirty-seven species or ...20082614375
thrombosis of the carotid artery following blunt trauma. 20092631311
[measurement of orthodontic appliance force using prototype sensors].in introductory remarks the most important biomechanical principles, which are relevant for the research, and conditions which must be satisfied presented in intraoral measuring of orthodontic forces were pointed out. first the aim of the research was defined, and then the investigation of mechanical properties of acrylics as a material for orthodontic appliances were carried out. the type of strain gauges, bonds and measuring system configurations, as well as measuring amplifiers and recording ...20082635572
the role of rt1.a major histocompatibility antigens in prolonging the survival of hepatic allografts in the rat. 19892650272
[treatment of cancer of the bladder]. 20092653234
effect of oxoplatinum and cbdca on renal functions in rats.changes in renal function in rats after single-dose intravenous administration of cbdca (cis-diammine-1,1-cyclobutane dicarboxylate platinum(ii) and oxoplatinum [cis-dichlorodiammine-trans-dihydroxo-platinum(iv)] at a dose of 20 mg/kg were determined and compared. renal function was monitored by several determinations of effective renal plasma flow (erpf), glomerular filtration rate (grf), plasma creatinine and urea and urine beta 2-microglobulin. a significant reduction of erpf and grf and a si ...19892654665
regional hemodynamic changes following hypovolemia in conscious rats.regional hemodynamic responses to subcutaneous injection of hyperoncotic polyethylene glycol (peg) were assessed in long-evans (i.e., normal) and brattleboro [i.e., arginine vasopressin (avp)-deficient] rats with chronically implanted, pulsed doppler probes. the results were compared with saline-injected time controls. peg injection elicited an early (30 min) selective mesenteric vasoconstriction in long-evans rats; 4-5 h after peg the mesenteric vasoconstriction was greater in long-evans than i ...19892655481
parkinsonism-plus syndromes. 20092657411
history of medicine in alaska. harriet crocker jackson schirmer, m.d. 20092662801
direct-reimbursement proposal may not live. 20092664596
adrenalectomy decreases nerve growth factor in young adult rat hippocampus.the effect of adrenalectomy on the level of nerve growth factor (ngf) in the hippocampus and on the distribution of choline acetyltransferase immunoreactivity in forebrain cholinergic neurons of developing rats was studied. biological and immunohistochemical determinations indicated that in 40-day-old rats, adrenalectomy reduced the ngf level in the hippocampus and the choline acetyltransferase immunoreactivity in the septal lateral bands. furthermore, autoradiographic studies showed that adrena ...19892664787
detection and treatment of gastroesophageal reflux disease.the diagnosis of gerd requires the thoughtful evaluation of a patient's symptoms and clinical course. in young patients with classical reflux symptoms in the absence of untoward complications such as structure, bleeding or pulmonary aspiration, antireflux treatment can be instituted without the need for diagnostic testing. a large number of patients will demonstrate a good clinical response to medical therapy. the diagnostic challenge arises when symptoms of reflux masquerade as cardiac and pulm ...20092668171
biologically active casein peptides implicated in immunomodulation.maternal milk should not only be considered as a nutrient, but also as a protecting agent against aggressions from the neonate's new environment. breast-feeding facilitates transmission of a passive immunity by multifunctional factors which have a direct effect on the neonate's resistance to bacterial and viral infections. among these factors are the main milk proteins, the caseins: during enzymic digestion of human and bovine caseins, immunomodulating peptides are released. corresponding synthe ...19892668358
laboratory survey of fluoroquinolone activity.fluoroquinolones are active against a wide variety of bacteria. the antibacterial spectra of fluoroquinolones encompass staphylococci, bacillus species, and corynebacterium species implicated in infections of the immunocompromised host; enterobacteriaceae; most intestinal pathogens; and many gram-negative organisms commonly causing nosocomial infections. haemophilus influenzae, haemophilus ducreyi, neisseria gonorrhoeae, neisseria meningitidis, and branhamella catarrhalis are highly susceptible ...19892672262
rickettsioses of the spotted fever group around the world.spotted fever group rickettsioses comprise rocky mountain spotted fever (rickettsia rickettsii), boutonneuse fever (r. conorii), north asian tick typhus (r. sibirica), queensland tick typhus (r. australis), rickettsialpox (r. akari), and oriental spotted fever (r. japonica). ticks or mites serve as the vector and reservoir hosts of the rickettsiae. these obligate intracellular bacteria invade vascular endothelial cells, which are damaged directly, causing increased vascular permeability. the ras ...19892677080
[tumor metastasis and growth factors].massive investigations are being carried out on growth factors. growth factors are an important determinant for the formation of successive tumor metastasis at target organs. we review the findings, including our data, of growth factors in relation to tumor metastasis.19892679395
interrelationships between digestive proteolytic activities and production and quantitation of toxins in pseudomembranous colitis induced by clostridium difficile in gnotobiotic mice.clostridium difficile pathogenicity is related to in vivo production of toxins, and it is of great interest to detect toxins produced in biological samples. several reports have shown that proteases in stools interfere with immunological methods for quantitation of toxin a. the purpose of this work was to estimate the relationship between the proteases and the c. difficile toxins produced in a gnotobiotic mouse model of pseudomembranous cecitis. cecal proteolytic activities hydrolyzed toxin a, a ...19892680988
growth inhibitors: molecular diversity and roles in cell proliferation. 20092681129
placental transport of calcium and phosphorus in pigs.the role of vitamin d in regulating placental transport of calcium and phosphate in pigs was studied using the "hannover pig strain" which suffers from pseudo-vitamin d-deficiency rickets, type i. sows and fetuses of normal phenotype (heterozygotes) and of homozygote phenotype which suffered from clinical symptoms of rickets were used. the homozygote animals are devoid of renal 25-cholecalciferol-1-hydroxylase. in the rachitic sows which normally depend on treatment with pharmacological doses of ...19892681666
jcda's 'quest' article: a tongue in cheek lampoon? 20092686820
long-term results of prosthetic therapy in adult cleft lip alveolus and palate patients.in the framework of the complex rehabilitation of cleft lip and palate patients the final phase of the dental therapy is attained with the definitive prosthetic treatment. this study comprises 148 prosthetically treated patients in the period 1973 to 1986. the results show that there are good preconditions for an undisturbed professional and social development of the cleft lip and palate patients through intensive dental care.20082691535
failla memorial lecture. the search for critical cellular targets damaged by heat. 20092694212
impairment of lymphocyte suppressive system in recent onset insulin-dependent diabetes mellitus. correlation with blood glucose and serum insulin levels.in a previous study, we observed an impairment of the theophylline-induced suppressive system in recent onset iddm patients, and demonstrated also a correlation with metabolic derangement. the aim of this study was to better investigate the relationship between theophylline sensitivity (ths) and blood glucose/plasma insulin levels in recent onset iddm patients subjected to preprogrammed variations by an insulin/glucose clamp with artificial pancreas. eight patients were studied within 8 weeks fr ...19892694717
biological and clinical evaluation of the transmandibular implant.the transmandibular implant has been shown to be a successful clinical solution to prosthetic rehabilitation of patients with gross mandibular atrophy. aspects of the biocompatibility of the implant material including the component metals in the alloy have been tested in an animal model utilizing sheep. the initial adelaide results in the clinical multicentre trial are presented. these were generally excellent and the reasons for the few failures are presented.19892695025
biological and clinical evaluation of the transmandibular implant.the transmandibular implant has been shown to be a successful clinical solution to prosthetic rehabilitation of patients with gross mandibular atrophy. aspects of the biocompatibility of the implant material including the component metals in the alloy have been tested in an animal model utilizing sheep. the initial adelaide results in the clinical multicentre trial are presented. these were generally excellent and the reasons for the few failures are presented.19892695025
systemic candidiasis with dic and candida endophthalmitis in a postoperative neonate.a full-term male neonate, weighing 2540 g at birth, was admitted to hospital on day 2 because of vomiting and severe dehydration. duodeno-duodenostomy was performed on day 5 for congenital duodenal atresia. the child was well postoperatively until day 9, when he developed fever. intermittent fever continued despite treatment with several antibiotics. he became seriously ill on day 15 and developed disseminated intravascular coagulation. treatment with antifungal drugs (amphotericin b and 5-flucy ...20092695030
[evaluation of the anti-influenza vaccine in students from basic high school].the anti-influenza vaccine was applied to a group of 217 students of "batalla del jigüe" secondary school which was compared to a group inoculated with the vaccine placebo with the view to evaluate the results of vaccine protection against the flue, as well as to determine its secondary effects in an adolescent population. there was a significant difference in the immunologic response in favor of the vaccine group as compared to controls for both strains of the antigenic contents of the vaccine ...19892701186
sce induction by ccnu and pregnancy. 20092704378
the effect of n-3 polyunsaturated fatty acids on lipids, haemostasis, neutrophil and monocyte chemotaxis in insulin-dependent diabetes mellitus.insulin-dependent diabetes mellitus (iddm) is associated with an increased risk of coronary artery disease (cad). there is some evidence that polyunsaturated fatty acids of the marine n-3 type (n-3 pufa's) may offer protection against cad. we have studied the effect of short-term dietary supplementation with n-3 pufas on lipids, haemostasis, neutrophil and monocyte chemotaxis in 10 patients with iddm. the patients were given 4 g daily of n-3 pufas (fish oil) for 6 weeks and were investigated bef ...20082706043
injury in u.s. army helicopter crashes october 1979-september 1985.all u.s. army class a and b mishaps of four types of helicopters occurring from 1 october 1979 through 30 september 1985 were reviewed. during this 6-year period, there were 298 crashes involving 303 aircraft. there were 1,060 individuals aboard the crashed aircraft and 611 were injured, 136 fatally. the most common cause of injury was the "secondary impact" caused by collapse of structure into occupied areas, by inadequate restraint of the occupants which allowed them to flail into structure, o ...20092709450
[an unusual slow course of systemic vasculitis with multiorgan involvement].this paper reports on an unusually slowly progressing course seen in systemic vasculitis of the median and smaller arteries and small veins associated with dermatomyositis, chronically active hepatitis, glomerulonephritis of the immune complex and restrictive cardiomyopathy in a 35-year-old patient. the authors discuss the difficulties in establishing the diagnosis and in finding the exact classification of this disease.20092714835
how accurate are faculty evaluations of clinical competence?to determine the degree and sources of variability faculty evaluations of residents for the american board of internal medicine (abim) clinical evaluation exercise (cex).20092723833
[space-occupying lesions in the gallbladder in cholecystolithiasis. freiburg gastroenterology consultation]. 20082725428
absence of genetic linkage of charcot-marie-tooth disease (hmsn ia) with chromosome 1 gene markers.we previously reported a large charcot-marie-tooth family not linked to the duffy blood group marker, supporting the existence of genetic heterogeneity in this neuropathy. in order to investigate the possibility of another disease locus on chromosome 1, we analyzed this family further, using dna polymorphisms of 6 genes. absence of linkage makes a second disease locus on chromosome 1 unlikely.19892725880
quantitative study of the dorsal lateral geniculate nucleus of the rat during the postnatal development.the chronology of dlgn development was studied in the rat from birth to 90 days postnatal (dpn). our results indicate the faster dlgn growth occurs from 1 dpn to 21 dpn. the neuronal number and density was calculated. no significant neuronal loss was detected in the period investigated but the present study shows evidence of an important decrease (of 75%) in the neuronal density between 7 dpn and 21 dpn. immediately the study of neuronal sizes and shapes was undertaken. approximately at 14 dpn t ...19892732462
[pressure effect on enzyme reactions]. 20092734449
alternative routes for the establishment of surface polarity during compaction of the mouse embryo.during the process of compaction, mouse 8-cell blastomeres flatten upon each other and polarize along an axis perpendicular to cell contacts. if the process of flattening is prevented, polarization can still occur, but does so in a lower proportion of cells than for control populations, and without the normal contact-directed orientation. we compared contact-directed and noncontact-directed processes to see if they involve common mechanisms. in nonflattened cells, surface polarization was favore ...19892744237
[present state of conservative breast therapy in canada]. 20082746948
distribution of a boronated porphyrin in murine tumors. 20092751609
phylogenetic diversity of the rickettsiae.small subunit rrna sequences have been determined for representative strains of six species of the family rickettsiaceae: rickettsia rickettsii, rickettsia prowazekii, rickettsia typhi, coxiella burnetii, ehrlichia risticii, and wolbachia persica. the relationships among these sequences and those of other eubacteria show that all members of the family rickettsiaceae belong to the so-called purple bacterial phylum. the three representatives of the genus rickettsia form a tight monophyletic cluste ...19892753854
[blood supply of skeletal muscles in reactive hyperemia].in 18 anesthetized cats, 60-sec occlusion of the m. gastrocnemius artery entailed a decrease in the muscle blood supply by 15-20 ml of the blood volume in the vessels whereas the post-occlusion increase in the blood flow restored the blood volume with 45% excess. the intravascular accumulation of the blood exerting a moderating effect upon the venous return while preserving the increased arterial inflow, can be regarded as an automatic way of limiting the hemodynamic excitation due to the postoc ...19892759286
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