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alpha-feto-protein (afp) and human chorionic gonadotropin (hcg) as biochemical markers of intracranial germ-cell tumours. 197992878
prostate-specific acid phosphatase: purification and specific antibody production in rabbits.demonstration of prostate-specific acid phosphatase by immunologic methods in tissue sections or in plasma necessitates a monospecific antiserum. this is produced by immunizing rabbits with pure prostate-specific acid phosphatase antigen, prepared from seminal fluid. the ejaculate is centrifuged, dialyzed against a citrate buffer, ph 4.8, and centrifuged again. the supernatant is brought onto a sephacryl s-200 superfine column and eluted with the same buffer. prostate-specific acid phosphatase-p ...197992890
tuberculosis. clinical aspects and diagnosis.the presentation of tuberculosis is variable depending on the severity of the infection, the age of the patient, whether the infection is primary or secondary, and whether the manifestations are due to inhalation of organisms or hematogenous dissemination. a definitive diagnosis is made by culture of the organism; spontaneously expectorated sputum is the most suitable specimen for diagnosing pulmonary tuberculosis. diagnosis of extrapulmonary tuberculosis frequently requires tissue biopsy. the c ...200192919
[relations between oxoglutarate transport function and variations of space in rat heart mitochondria (proceedings)]. 197992958
antigenic similarity of morphologic type ciii1 bacteriophages.the aim of the study was to demonstrate antigenic differentiation among bacteriophages belonging to the same morphologic type--ciii1 according to krzywy and slopek or a2 according to ackermann. twenty-six bacteriophages which multiplied on various strains of bacteria of the genera escherichia, shigella and klebsiella, were studied. serologic tests were done by the quantitative complement fixation test. immune sera against 5 phi e. coli. d8 sh. flexneri, g35 sh. sonnei and kl7 klebsiella bacterio ...197992976
an improved immunoelectrophoretic methodology for the evaluation of protein caloric malnutrition.an improved technique of two dimensional immunoelectrophoresis of serum proteins on gelatinized cellulose acetate for routine evaluation of protein nutritional state is described. the method, which allows the estimation of more than 30 protein fractions, proves extremely useful in monitoring the effectiveness of total parenteral nutrition and protein metabolic conditions. sera samples from healthy subjects and cachectical neoplastic patients have been examined and preliminary results are reporte ...200192995
[two-layer rocket-electrophoresis on cellulose-acetate membranes].two-floor rocket-electrophoresis on gelatinated acetate cellulose membrane "cellogel" has been developed. the method is based on electroimmunodiffusion detection of the antigen on the acetate-cellulose membranes, containing monospecific antiserum of the test-system. the procedure is followed by the detection of precipitation bands ("rockets") by staining, if the reaction is conducted in the visible zone or by the further treatment of the acetate-cellulose strips, containing invisible precipitate ...197993004
[immunosuppression in rabbits using the serum of splenectomized animals (author's transl)]. 197993023
three-dimensional arrangement of sarcoplasmic reticulum in crayfish as seen by high voltage electron microscope.sections several micro thick of single fibres from the crayfish muscle were examined by means of a high voltage electron microscope to find out the geometry of the sarcoplasmic reticulum (sr). a sufficient contrast of the sr was achieved by lead acetate histochemical method for calcium. longitudinally oriented files of sr vesicles at the level of a bands and interruptions in otherwise continuous sr net are the most conspicuous features.200193024
[palliative non-surgical bile duct drainage]. 200193044
the effect of dose loading and of double labelling with 57co and 125i on the tissue distribution in animals.dose loading effects upon the performance of 57co-bleomycin as a tumor localizing agent have been investigated in rhabdomyosarcoma bearing wag/ry rats. the addition of non-radioactively labelled co-bleomycin increased the relative uptake of 57co-bleomycin in rapid growing tumors, but the addition of non-chelated bleomycin had no influence at all. in our experimental system, iodinated bleomycin generally labelled by reaction with icl, was found to be an unsatisfactory tumor localizing agent. in o ...197993048
[hygienic standards for a mixture of hexachlorane and phosalone in the atmosphere]. 197993066
[medical management of tachycardias (author's transl)].guidelines for a step-wise plan of treatment of tachycardias have been compiled based on clinical empirical experience and with the aid of surface electrocardiograms, intracardial electrograms and stimulation techniques. the plan is primarily with the aid of surface electrocardiograms, intracardial electrograms and stimulation techniques. the plan is primarily oriented with respect to the antiarrhythmic efficacy, the adverse reactions and the practicability of the respective agents. any type of ...200193075
quantitative succinate-dehydrogenase histochemistry. iii. variations in histochemical succinatedehydrogenase activity in different cross-sections of the same muscle fibre.the variation in histochemical sdh-activity at different levels in the same muscle fibre was determined in muscle fibre cross-sections both by visual classification and quantitative determination of the formazan-deposits. this work resulted in a confirmation of the earlier micro-biochemical studies of spamer and pette (1977, 1979) and lowrey et al. (1978) that the activity of enzymes of the citric acid cycle is not homogeneously distributed in a muscle fibre over its entire length. in addition i ...200193101
histochemical reactions of gastrointestinal mucosubstances with high iron diamine after prior oxidation and methylation of tissue sections.high iron diamine reactions after the prior methylation and oxidation of tissue sections with performic acid or potassium permanganate (metox-hid or ox-met-hid) in epithelial mucosubstances and in mucosal mast cells were studied in tissue samples from the human gastrointestinal tract and were compared with reactions with high iron diamine without any pretreatment (hid) and high iron diamine with the prior methylation (met-hid). high iron diamine reactions after the prior oxidation (met-ox-hid, o ...197993103
analysis of vibrio parahaemolyticus soluble antigens by employing passive hemagglutination.the passive hemagglutination assay was explored as a sensitive test of immunological reactivity of endotoxin and other antigens prepared from selected strains of vibrio parahaemolyticus. the tannic acid procedure for passive hemagglutination, commonly used with protein antigens, was the only procedure yielding good results with v. parahaemolyticus protein extracts, endotoxins, and related preparations. these results were probably due to the presence of large amounts of protein in the v. parahaem ...197993111
experimental infection with ancylostoma caninum larvae in mice. vi. serum protein pattern use due to repeated exposures to infection.three mice groups were infected with various repeated doses and other four groups with single doses of ancylostoma caninum larvae. serum samples collected at various intervals were analysed electrophoretically. the results were compared first with an uninfected control group and then with those of the corresponding non-immunized single-dose-infected groups. remarkably decreased values of albumin, increased beta globulin and increased total globulins with a decreased a/g ratio were observed. ther ...197993128
induction of ecotropic endogenous murine leukemia virus in long-term bone marrow cultures from mouse strains of varying natural leukemia incidence. 197993145
perinatal mortality. 200193220
paediatric surgeons are necessary. 200193224
[methods to prepare histological microautoradiographs for evaluation by automatic image analysis (author's transl)].a prerequisite for automatic image analysis of histoautoradiographs is the arrangement of the silver grains within the same plane of focus. this can be obtained by semi thin sections of 1 micrometer in thickness. a sufficient contrast for the determination of the nuclear areas and the overlying silver grains at the same time can be reached by staining the preparations with kernechtrot or feulgen nucleal reaction. if a higher image contrast is desired sections measuring 2 micrometer or more in th ...200193233
complications associated with aphakic contact lenses.complications associated with rigid contact lenses are more frequent in aphakia. the limited dexterity of older patients not only may prove an insurmountable barrier to the mastery of daily contact lens insertion and removal, but also may produce significant direct eye trauma, its seriousness determined by the integrity of the cataract wound. since prolonged wear of aphakic contact lenses is the rule rather than the exception, the risk of irreversible corneal changes such as vascularization and ...200193260
[disadvantages in the use of mercurochrome in the treatment of the donor area in skin grafts]. 200193296
suppression by antithyroid drugs of experimental hepatic necrosis after ethanol treatment. effect on thyroid gland or on peripheral deiodination? 197993320
[palliative therapy of stenosing reflux esophagitis]. 200193354
severe skin pain after puva treatment.severe skin pain lasting one or two months occurred in 8 of 210 patients treated with puva. the pain started 4--8 weeks after the initial dose, mostly about one week after discontinuation of the treatment. it was a prickling, burning pain, usually coming in bouts and confined to limited areas "deep under the skin". in some respects the pain was related to itching, but the patients could easily distinguish between the two sensations. a variety of drugs was tried, but none had any noteworthy effec ...200193376
a neuropathologic study of whipple's disease.a patient with whipple's disease developed massive and irreversible cns involvement after a drug-induced intestinal remission. the multifocal brain lesions were apparent grossly with the heaviest concentration being noted in rhinencephalon, diencephalon, and mesencephalon. this patient exhibited progressive neurologic deterioration, although viable organisms could not be identified in the brain at autopsy. astrocytes, pericytes, and choroid plexus cells attempted to dispose of the organism, in a ...199993389
[immunogenicity of human outer segment in human uveitis (author's transl)]. 197993410
[choroidal neovascularization in the photocoagulated retina with diabetic retinopahy--a light and electron microscopic study (author's transl)]. 199993415
relationship of seminal volume to size and disease of the prostate in the beagle.the seminal volume of young adult beagles was correlated with the size of and disease in their prostates. the ejaculate volume of naturally collected semen increased in a linear manner with prostatic weight in dogs with normal or glandular hyperplastic prostates. this correlation was not observed in the dogs with cystic hyperplasia, in which there was a reduction in volume of 50% in the semen produced for each gram of prostate. there were no significant differences in other seminal characteristi ...197993426
hormonal regulation of osmotic and ionic balance in the haemolymph of the larvae of dragonfly, aeschna cyanea (müller) (odonata : aeschnidae).the present studies provide an evidence of an active involvement of the neurosecretory a cells of the thoracic ganglia in both, the internal hypo- and hyperosmotic regulation in the larvae of aeschna cyanea.199993445
[cis expression, at complementation, of mitochondrial mosaic gene exons regulating cytochrome b in saccharomyces cerevisiae (proceedings)]. 197993454
a novel class of schizosaccharomyces pombe mutants, phenotypically unable to grow on glycerol, a respiratory substrate, but still able to oxidize glycerol aerobically [proceedings]. 197993469
[cerebrospinal fluid monoamine metabolites and cyclic nucleotides in the patients with epilepsy (author's transl)]. 199993481
[availability of the measurement of plasma beta-thromboglobulin (beta-tg) for cerebrovascular diseases (author's transl)]. 199993482
the use of the voiscope in improving the speech of profoundly deaf children. 199993485
progress report on an evaluation of speech therapy for aphasia. 199993486
[smoking and serum alpha 1-antitrypsin in 1296 healthy men (author's transl)].serum alpha 1-antitrypsin (alpha 1at) was measured by radial immunodiffusion in 1296 healthy men aged 18--50 years. other biological criteria, including leukocyte count and alpha 2-globulins were measured and the subjects were given a detailed questionnaire on their smoking habits. results showed a very strong positive relationship between smoking and serum alpha 1at: the heavy smokers had a serum alpha 1at 20% higher than the non-smokers, and among subjects who stopped smoking, the level return ...199993523
alteration in the immunochemical dominance of determinants following the chemical modification of ox insulins: implications for the structure of the ox insulin monomer in solution.insulins of differing species, together with chemically modified insulins, were used in cross-reactivity experiments employing selected antisera raised to ox insulin in the harley guinea-pig. the immunogen had been administered as a water-in-oil emulsion, using h. pertussis vaccine as adjuvant. antibody was generated by determinants in the c-terminus of the b chain plus the adjacent n-terminus of the a chain, in the central core of the a chain (a8-a14 region) and in its anti-parallel n-terminus ...197993526
modulatory effects of oestrogen on immunological responsiveness. ii. suppression of tumour-associated immunity in patients with prostatic cancer.the effect of oestrogen (diethylstilboesterol diphosphate, des-p) on immunity to tumour-associated antigens in patients with prostatic cancer was evaluated by leucocyte adherence inhibition, a suggested in vitro correlate of cellular immunity. significant (p smaller than 0.05) suppression of immunity to malignant prostate was observed in thirty out of thirty-one patients following pre-incubation of their leucocytes with therapeutically significant levels of des-p. suppression of tumour-associate ...199993529
vinblastine, methotrexate, bleomycin, in the management of head and neck cancer. 199993540
ontogeny of immunity in amphibians: changes in antibody repertoires and appearance of adult major histocompatibility antigens in xenopus.larval xenopus anti-2,4-dinitrophenyl antibodies of the low-molecular weight type can be analyzed by isoelectric focusing (ief). within a clone of genetically identical animals, tadpoles make antibodies whose ief spectrotypes are shared by most of the individuals. adults of the same clone also make antibodies of identical spectrotype, but the adult pattern can be very different from the larval one, although both responses are heterogeneous. the larval spectrotypes that one cannot see in a primar ...199993547
identification and characterization of trypsin, chymotrypsin and elastase inhibitors in porcine serum.characterization of the trypsin-, chymotrypsin- and elastase-inhibiting properties of porcine serum was carried out by gel filtration on ultrogel, aca 44, and agarose gel electrophoresis with subsequent processing for protease-inhibiting activity. moreover, by allowing the fractions obtained from gel filtration to react with antibodies to porcine serum protease inhibitors, the specific inhibiting properties of these inhibitor molecules were identified. at least six protease inhibitors were ident ...197993564
surface-associated host proteins on virulent treponema pallidum.a surface coat of host serum proteins was detected on virulent treponema pallidum by sodium dodecyl sulfate-gel electrophoresis. the loosely associated serum proteins could be removed by repeated washings in a protein-free medium. washed t. pallidum retained the ability to readsorb numerous host proteins from rabbit serum as well as iodinated rabbit or human albumin. in addition, various avidly associated host serum proteins including albumin, alpha(2)-macroglobulin, transferrin, ceruloplasmin, ...197993574
antigenic heterogeneity of the non-serogroup antigen structure of neisseria gonorrhoeae lipopolysaccharides.studies of the antigenic structure of the polysaccharide component of gonococcal lipopolysaccaride (lps) indicated that the non-serogroup antigen structure is antigenically heterogeneous. immunodiffusion studies of gc4 strain 8551 indicated that in addition to the gc serogroup determinent, this polysaccharide contains two other sets of determinants, one which is shared with the other five gc serogroups and a second which is shared by the gc1 and gc3 serogroups. enzyme-linked immunosorbent assay ...197993575
alpha-fetoprotein inhibits antibody binding to acetylcholine receptor. significance for myasthenia gravis and other autoimmune diseases. 197993589
the binding of streptomycin to ribonucleotides.incubation of streptomycin (sm) with [32p]5'-ribonucleotides at ph 7.0 produces fractions that migrate towards the cathode in high voltage electrophoresis (hve) separations at ph 3.5. sm appears to interact with pg, pa and pc but not with pu. the appearance of these [32p]-labeled fractions is dependent on incubation time and sm concentration. incubation of nucleotides with dihydrostreptomycin (dsm) or sm reduced with sodium cyanoborohydride (nabh3cn) at ph 5.0, does not produce detectable change ...197993596
genetic variation in the m antigen of group a streptococci: reassortment of type-specific markers and possible antigenic drift.the phylogenetic relationships of 73 strains of group a streptococcus isolated over a six-year period from a population with a high prevalence of streptococcal infections were analyzed with use of four serotype-specific markers: the serum opacity factor (of), the t antigen, the determinant of the m antigen that precipitates with antibody, and the m antiphagocytic determinant. of inhibition tests divided the strains into five subtypes: a, b, c, d, and e. strains within subtypes a, b, and c shared ...197993611
immunoprecipitation of triton x-100-solubilized mycoplasma mycoides proteins.mycoplasma mycoides subsp. mycoides (pg1 and strain y) proteins were solubilized in triton x-100, and the antigenic proteins were precipitated from this complex mixture by addition of antiserum and then separated by two-dimensional gel electrophoresis. of the 300 proteins solubilized, about 10 were precipitated. proteins of pg1, a slow-growing, small colony (sc) strain, were precipitated by antiserum to pg1 and by antiserum to strain y, a fast-growing, large colony (lc) strain. similarly, strain ...197993614
treatment of myasthenia gravis. report on 139 patients.in the treatment of myasthenia gravis (mg) considerable progress has recently been achieved. our experience is based on the observation of 139 patients with an average follow-up of 3 years and 4 months. a treatment plan and results are presented. indications for thymectomy: all cases of mg in adult life, apart from ocular myasthenia without radiological thymoma and without electrophysiological and pharmacological signs of generalization; before puberty only cases with radiological thymoma and se ...199993623
pattern reversal evoked cortical responses in normals. a study of different methods of stimulation and potential reproducibility.using a commercially available television set for stimulation of 78 healthy subjects, the upper limit of normal for the latency of the major positive wave (p 100) of checkerboard pattern reversal evoked potentials is practically the same as that obtained by employing slide projector combined with a rotating mirror. potentials evoked by a small pattern, for purely foveal stimulation, were often difficult to evaluate exactly. fixation of a large pattern at the upper border of the stimulus field br ...199993635
[studies on elastase in pancreatic diseases (author's transl)]. 199993654
[changes in the physiologic properties of a chemostat culture of propionibacterium shermanii during growth limitation by a deficiency of sodium lactate].a chemostat curve has been constructed for changes in the propionibacterium shermanii population density with an increase in the flow rate of the medium from 0.04 to 0.55 h-1 upon limitation of the growth with sodium lactate deficiency. the curve differs from the classic chemostat curve described with the monod equation, thus indicating changes in metabolism at different growth rates. fermentation of lactate to acetic and propionic acids by the culture is most complete at low flow rates of the m ...197993687
substance p as neurogenic mediator of antidromic vasodilation and neurogenic plasma extravasation. 197993706
location of bladder preganglionic neurons within the sacral parasympathetic nucleus of the cat.sacral parasympathetic preganglionic neurons innervating the urinary bladder were labelled by applying horseradish peroxidase (hrp) to branches of the pelvic nerve at the neck of the bladder. bladder preganglionic cells were located primarily in the intermediolateral grey matter of sacral cord segments 1, 2 and 3 and extended from the ventral end of the central canal to the inferior margin of the dorsal horn. dendrites extended into the dorsolateral funiculus, toward the lateral edge of the dors ...197993725
problems associated with prolonged wear soft contact lenses.complications of prolonged wearing of soft contact lenses are corneal infection, peripheral vascularization, giant papillary conjunctivitis and allergy, sterile ulcers, corneal warping, lens infection, protein and calcium deposits, lens fragility, and problems with disinfecting solutions. further long-term studies are needed to compare the safety of prolonged wear soft contact lenses with the safety of intraocular lenses, on which long-term studies are currently being done.197993736
[mechanism of antibiotic action]. 199993768
potentiation of the hepatotoxicity of carbon tetrachloride following preexposure to chlordecone (kepone) in the male rat. 197993792
lack of dr antigens on human b-lymphocyte-mouse fibroblast hybrids that express hla-a,b antigens. 197993795
comparison between hla-d (lcl) and dr typing. 199993807
in vitro primary immunization of human peripheral blood lymphocytes to klh: evidence for hla-d-region restriction. 197993813
retention of dr-specific memory in primed lymphocytes grown in pha-conditioned media. 199993819
[correlation of the hourly and daily clearance in prostate adenoma]. 199993822
[evaluation of the restoration of micturition after transvesical adenomectomy of the prostate using a urodynamic flow measurement method]. 199993823
palliative operations for incurable gastric cancer. 199993827
recent advances in applied malaria immunology.our present knowledge of cellular and humoral factors which are involved in immunity to plasmodial infections are discussed. immunization against plasmodial infection has been achieved in birds, rodents, simians, and humans. avian hosts have been immunized against gametocytes which resulted in inhibition of gametocytes within the mosquito vector. immunization of humans against plasmodial gametocytes would indirectly protect them against malaria by blocking mosquito transmission to other suscepti ...197993828
[allergenic properties of the blood serum of drug allergy patients]. 197993831
antibody response against foot and mouth disease virus (fmdv). part ii: responses measured in fractionated sera of infected steers with complete virus, trypsin treated virus, 12 s virus subunits, via and heterologous virus. 197993833
[the current discussion: drug treatment of pain caused by cancer]. 199993853
rna modulating specific and nonspecific immune responses. 197993861
role of nonspecific and specific suppressor factors in immunity. 199993866
myelin basic protein treatment of experimental allergic encephalomyelitis in monkeys.treatment of experimental allergic encephalomyelitis (eae) in two strains of monkeys with large amounts of myelin basic basic protein (bp) fails unless an adjunct is also used. in both strains the adjunct by itself is more effective than bp by itself, but in the one strain which could be investigated sufficiently, the combination can be made almost totally effective in reversing eae. the adjunct varies with the strain of monkey, an antibiotic in macaca mulatta and a steroid in macaca fasciculari ...197993874
characterization and mode of action of a bacteriocin produced by a bacteroides fragilis strain.a bacteroides fragilis strain produces a low-molecular-weight (13,500 to 18,700), proteinaceous bacteriocin during the stationary growth phase. the extracellular bacteriocin is not inducible by ultraviolet light or mitomycin c and is stable between ph 7.5 and 8.2. the majority of the bacteriocin is thermolabile, but a small proportion (3%) of the bacteriocin is stable after autoclaving at 121 degrees c for 15 min. killing of sensitive bacteroides cells follows single-hit kinetics, and the intera ...197993876
relaxation of striated muscle by low concentrations of atp [proceedings]. 199993891
receptive field organization in areas 17 and 18 of the cat [proceedings]. 197993893
determination of the quaternary structure of alpha-d-mannosidase from medicago sativa l. [proceedings]. 199993904
analysis of rna-binding proteins of cryptobiotic gastrula of artemia saline [proceedings]. 199993910
study of spectrin phosphorylation and polymerization in normal and spherocytic red blood-cells [proceedings]. 199993915
integration site of bovine leukemia virus dna in the bovine genome [proceedings]. 197993923
identity and properties of multiple neuroleptic-binding sites in rat limbic brain areas [proceedings]. 197993926
effects of x-rays on the chloroplasts of acetabularia mediterranea [proceedings]. 199993929
albumin synthesis in isolated hepatocytes of control and diethyl-nitrosamine-treated rats, maintained in suspension or in monolayer culture [proceedings]. 197993933
semicarbazide-sensitive amine oxidase in rat aorta: a plasma-membrane enzyme [proceedings]. 197993954
diagnosis and staging of prostatic cancer by transrectal ultrasonography. a preliminary study.sixty men (7 normal, 53 with prostatic disease) underwent transrectal ultrasonic scanning of their prostates in order to assess the technique and evaluate its reliability in the detection and staging of prostatic cancer. the prostatic capsule was clearly seen in 58 men; non-integrity of the capsule occurred only in those with proven cancer (17 cases). an ultrasound diagnosis of cancer was made for 32 of 33 men with proven disease and it was shown that ultrasound demonstrated anterior perforation ...199993975
pancreatic islet cytology of the himalayan toad, bufo himalayanus. 199994018
[monitoring the course of malignant neoplasms of the genital organs in women by means of determination of blood serum level of fucose, sialic acid, cea and afp]. 199994024
conversion of androstenedione to estrone in human fibroblasts cultured from prostate, genital and nongenital skin. 197994031
demonstration of specific antigenecity of various fractions of human liver homogenate. 197994039
molecular perspectives of monovalent cation selective transmembrane channels. 199994042
[value and limit of photocoagulation for juxtafoveolar sub-retinal vessels (author's transl)].sub-retinal new vessels arising from the choroid are the most dangerous components in disciform maculopathies. the greatest advance made in their treatment has been due to the use of photocoagulation over the last few years, but their destruction by this method is still a very controversial subject. the aim of the present study was to define which lesions should be treated and which should not. results demonstrated that the use of photocoagulation to destroy new vascular membrane which is very c ...199994069
effects of tamoxifen on the binding and metabolism of testosterone by human prostatic tissue and plasma in vitro.the in-vitro metabolism of testosterone in benign and malignant prostatic tissue was examined and distinct quantitative differences between the two types of specimens were observed. the major metabolite of testosterone in the hyperplastic prostate was 5 alpha-dihydrotestosterone and a high 3 alpha(beta)-hydroxysteroid dehydrogenase activity was also detected. in the malignant tissue, 5 alpha-reductase activity was considerably reduced and there was little or no androstanediol formed; the 17 beta ...197994084
simultaneous treatment of toxic diffuse goiter with i-131 and antithyroid drugs: a prospective study.we report a prospective study to avaluate the effect of antithyroid drugs containing the sulfhydryl radical on the outcome of i-131 (rai) therapy. twenty-four male patients withe toxic diffuse goiter were assigned randomly into tow treatment groups: group a received rai treatment while on antighyroid drugs after attainment of euthyroidism; group b received no antithyroid drugs before, or when, rai was given. patients in each group received a dose of rai calculated to deliver approximately 5000 r ...199994089
[palliative chemotherapy with 5 fu and cpm in cancer of the prostate with bone metastases resistant to oestrogens. a clinical trial (author's transl)].the efficacy of an association of cyclophosphamide (cpm) and 5-fluorouracil was studied in 15 patients with prostate cancer not responding to oestrogen therapy, and more particularly its effect on pain due to bone metastases. no objective improvement was noted with this association, but there was a definitite reduction in bone metastases pain in 5 of the patients, with an average remission time of 4 months. half of the patients had nausea and vomiting, but in spite of this digestive intolerance ...199994108
[identification of b-, t- and "zero" lymphocytes by staining for acid phosphatase]. 199994125
isolation and characterisation of a strain carrying a conditional lethal mutation in the cou gene of escherichia coli k12.a strain which carries a mutation conferring clorobiocin resistance and temperature sensitivity for growth was isolated from escherichia coli k12. genetic mapping and the molecular weight of the gene product suggest that the mutation is in the cou gene, specifying a sub-unit of dna gyrase. nuclear organisation and segregation and placement of septa are grossly abnormal in the mutant at 42 degrees c. rna synthesis and initiation of dna replication are also affected at the restrictive temperature ...197994144
studies on fibronectin in the skin. iii. indirect immunofluorescence studies in lichen planus.fibronectin is a glycoprotein which is responsible for a varity of functions in the human organism, such as mediation of contact between cells and between cells and fibres, opsonic qualities, interaction in the stabilization of fibrin, etc. fibronectin is an important constituent of the ground substance having a special affinity to collagen. in indirect immunofluorescence studies its presence has been abundantly demonstrated in normal human skin, in collagen-rich structures such as the basement ...197994206
photolysis of mast cells in presence of protoporphyrin.the effects of ultraviolet and visible irradiation in presence of protoporhyrin upon mast cells were investigated. rat peritoneal mast cells were suspended in a medium containing varying concentrations of protoporphyrin and were irradiated using a mercury vapor lamp. the release of histamine is related to both the concentrations of protoporphyrin and the period of irradiation. comparatively negligible amounts of histamine were released when the cells were irradiated in absence of protophyrin or ...197994207
erythemal and pigmentary phototest reactions in polymorphic light eruptions.the erythemal and pigmentary skin reactions in 110 patients with chronic polymorphic light eruptions (pmle) and in 154 control persons were investigated by phototesting with a medium pressure mercury lamp. recording the erythemal threshold (med) at 2-h intervals for up to 24 h after irradition disclosed no differences between pmle patients and controls. there was, however, a tendency for the erythemal reaction to subside more slowly in the pmle patients; this tendency reached a statistically ver ...199994208
diffuse cutaneous mastocytosis: a report of neonatal onset.a child developed diffuse cutaneous mastocytosis when 20 days old. his prognosis appears good, compared with other reports of similar neonatal onset.199994218
induction of delayed-type sensitivity to leishmania parasite in a case of leishmaniasis cutanea diffusa with bcg and cord-factor (trehalose-6-6' dimycolate).the delayed hypersensitivity against the leishmania parasite was restored to a patient who had suffered from diffuse cutaneous leishmaniasis (dcl) for 26 years, by the application of an ointment containing heat-killed and lyophilized bcg and cord-factor (trehalose-6-6'-dimycolate) after stripping the affected and adjacent areas with scotch-tape.197994221
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