Publications

'catatonia' due to disulfiram toxicity.	in an alcoholic patient, catatonia developed while he was receiving disulfiram (antabuse). resolution of the question whether his state was classically catatonic required a detailed review of the literature on the subject. the conclusion reached is that the original definition still holds for psychiatric illness, but application of the term to neurological and metabolic states has often been based on imprecise criteria and failure to consider akinetic mutism and extrapyramidal motor disturbances ...	2009	2742552
[immunologic studies of secretory otitis].	evaluation of total serum proteins and rist immunoelectrophoresis of immunoglobulins igg, iga and igm were carried out on a group of 35 children of both sexes suffering from secretory otitis. the transudate aspirated from the middle ear was examined only by immunoelectrophoresis. the values for albumin and gammaglobulins were decreased for all the patients. the values for rist were significantly lower than those where an allergic cause was present. the values for immunoglobulins in transudate we ...	2009	2745169
comparative in vitro susceptibilities of 504 bacteremic isolates to ticarcillin plus clavulanic acid and other antimicrobial agents.	a total of 504 clinical bacteremic isolates were tested for susceptibility to ticarcillin-clavulanic acid and 12 other antibiotics. ticarcillin-clavulanic acid showed superior antibacterial activity compared to penicillin, mezlocillin, piperacillin, ticarcillin, gentamicin, and amikacin against bacteremic isolates of methicillin-susceptible staphylococcus aureus and staphylococcus epidermidis. however, ticarcillin-clavulanic acid's activity was inferior to that of vancomycin against methicillin- ...	1989	2752713
bidirectional closure of the rostral neuropore in the human embryo.	the length of each neuropore was measured in 23 human embryos of stages 10-12 (about 22-26 days), and the closure of the lips of the rostral neuropore was studied in 24 embryos of stage 11 (about 24 days), with particular reference to the terminal lip. graphic reconstructions were prepared from two particularly suitable examples, and mitotic figures were plotted for one of these. the lengths of the rostral and caudal neuropores are basically similar, but the rostral opening closes 1 day earlier ...	1989	2756902
on the oceanic experience.		2008	2760405
on the oceanic experience.		2008	2760405
career options of occupational physicians.		2009	2769461
[cardiovascular risk factors in children and adolescents in fuenlabrada: objectives, features of the population, design, participation, equipment, laboratory technics, and quality control].	fuenlabrada is at the present time the most industrialized town placed at the south are of madrid. this population has some peculiar attractive characteristics from the epidemiologic point of view. perhaps the most important is that the majority of its inhabitants are immigrant from other depressed rural areas of the country, with a low socio-economic and cultural level. the new conditions of life could have changed the life expectation and the causes of morbidity and mortality of this populatio ...	1989	2772364
human intrinsic factor. its primary structure compared to the primary structure of rat intrinsic factor.	human intrinsic factor was digested by trypsin and the resulting peptides purified by gelfiltration. two peptides were sequenced to a total of 61 amino acid residues. including the sequence for the n-terminal peptide and four cyanogen bromide peptides previously reported, we have now determined a total of 163 amino acid residues, that is a fraction of about 0.40 of the primary structure of human intrinsic factor. the 110 of the 163 residues known of human intrinsic factor are identical to the se ...	1989	2772549
reference methods--with special reference to cholesterol.	through the work of the committee for reference methods in nordkem and the scandinavian society for clinical chemistry, a hierarchy of methods was established in denmark in 1982 for accuracy assurance of determination of total cholesterol in serum. the hierarchy makes it possible for any laboratory to relate their results of measurements on fresh samples from humans, to the results obtained on the same samples by reference methods, which have been adjusted to definitive methodology. proficiency ...	1989	2772557
regional histochemical aspects of xanthine oxidase activity in ischemic and reperfused small intestine of the rat.	the study describes regional changes of xanthine oxidase and succinate dehydrogenase activities as shown by the ischemic and reperfused small intestine of the rat. the results are obtained with enzyme histochemical methods, including densitometrical verifications, and are substantiated with biochemical enzyme determinations. the decrease of xanthine oxidase activity was best visible in the anoxic duodenum and jejunum, where the findings of histochemical enzyme determinations agreed with those ac ...	1989	2776176
blockage of urinary catheters: role of microorganisms and constituents of the urine on formation of encrustations.	long-term indwelling urinary catheters may become blocked in some patients by formation of encrustations made up of aggregated struvite crystals while other patients rarely develop blocked catheters. we have designated these groups as "blockers", "intermediates" or "non-blockers". to further understand this phenomenon we followed 32 catheterized elderly women in a nursing home. catheters were changed six times at 2 week intervals. patients tended to remain as "blockers", "intermediates" or "non- ...	1989	2778465
cholesterol-based personal risk assessment in coronary heart disease.	using data from the national health and nutrition examination survey (nhanes ii) 1976-1980, we demonstrate how cross-sectional total serum cholesterol surveillance data can be used by an individual to assess current and future personal cholesterol risk status. we propose statistical models, based on a person's current measured cholesterol level and the relationship between cross-sectional age and cholesterol percentile estimates, that will allow prediction of future cholesterol levels or the age ...	2009	2785282
results of the flow cytometry actg quality control program: analysis and findings.	the aids clinical trial group's (actg) immunology committee was charged with initiating a quality control program for all laboratories participating in the actg program reporting flow cytometry data. forty-one laboratories were evaluated. this report defines the goals of this program and the subsequent findings after 19 send-outs were made. both hiv positive volunteer donors and normal age-matched donors were used. sample sets included both heparin and edta anticoagulated bloods. laboratories we ...	1989	2785890
interleukin 1 in rheumatoid arthritis: potentiation of immune responses within the joint.	specific immunoassays were used to measure il-1 peptides in the serum and synovial fluid of patients with rheumatoid arthritis (ra) and in the serum of age-matched healthy controls. patients with ra had raised levels of both il-1 beta and il-1 alpha in their sera compared to controls. synovial fluid levels of il-1 beta significantly correlated with immunoreactive il-2 and soluble il-2 receptor (sil-2r). in addition, incubation of synovial fluid mnc with human recombinant (hr) il-1 caused a dose- ...	1989	2789325
b-cells in the chicken harderian gland.		1989	2798476
b-cells in the chicken harderian gland.		1989	2798476
[neurobehavioral evaluation of term and preterm neonates].	the brazelton neonatal behavioral assessment scale in the actual version (1984) was used by the authors to examine neurobehavioral performance of two different groups of newborns (one fullterm and the other preterm). although the average difference between gestational age in the two groups was not very high, the results show that the preterms were significantly inferior in habituation, motor and supplementary items. a lower gestational age results correlated with reduced performance in newborn.	2008	2798987
cloning of ureaplasma urealyticum dna sequences showing genetic homology with urease genes from gram-negative bacteria.	dna chromosomic sequences from ureaplasma urealyticum were shown, by dna hybridization, to possess homology with providencia stuartii urease genes. the homologous ureaplasma dna fragment was cloned in escherichia coli and a dna probe, designated ic61 probe was specific for only the urease-producing u. urealyticum among the mollicutes. genetic homology shown between the ic61 probe and urease genes from campylobacter pylori, e. coli and p. stuartii suggests that (1) the cloned dna fragment from u. ...	1989	2799066
in-vitro activity of meropenem against clinical isolates obtained in canada.	the in-vitro activity of meropenem, a new parenteral carbapenem, was compared with that of imipenem, ceftazidime, cefotaxime, piperacillin, gentamicin and, where appropriate, other antibiotics against recent clinical isolates and characterized beta-lactamase producers. mics were determined by a standard agar dilution procedure and two inocula (10(4) and 10(6) cfu) were used throughout. meropenem inhibited 90% of isolates of escherichia coli, klebsiella pneumoniae, proteus mirabilis, indole-posit ...	1989	2808216
"a few bad apples?".		2009	2812134
"a few bad apples?".		2009	2812134
["lumbo-sciatica" diagnostic error in tumor of the lumbosacral roots or the lumbosacral plexus].		2009	2812161
["lumbo-sciatica" diagnostic error in tumor of the lumbosacral roots or the lumbosacral plexus].		2009	2812161
choosing your professional liability insurance.		2009	2812953
choosing your professional liability insurance.		2009	2812953
smoking and other tobacco use.		1989	2815598
smoking and other tobacco use.		1989	2815598
false aneurysms after prosthetic reconstructions for aortoiliac obstructive disease.	several aspects of false aneurysm development after prosthetic resconstruction for aortoiliac obstructive disease were studied. for this purpose the long-term results (up to 20 years of follow-up) of 518 patients with implanted arterial prostheses in the aortoiliofemoral tract were retrospectively evaluated. completeness of follow-up data was 83.2% 15 years after operation. a total of 101 false aneurysms (21 aortic, 53 iliac, and 27 femoral) were detected in 69 patients and verified by operation ...	2009	2818034
the effect of age on the renal response to pth infusion.	the renal responses to pth infusion were compared in two age groups of healthy subjects. basal nephrogenous cyclic amp (ncamp) was higher (1.68 +/- 0.74 vs. 0.97 +/- 0.50 nmol/dl gf; p less than 0.05) and tmpo4/gfr was lower (0.93 +/- 0.21 vs. 1.16 +/- 0.14 mmol/liter; p less than 0.025) in 10 elderly subjects compared with 12 young adults. creatinine clearance was decreased in the elderly (84.8 +/- 25.7 vs. 144.7 +/- 43.2 ml/min; p less than 0.005) and serum ipth tended to be increased (0.15 +/ ...	2009	2825933
the effect of age on the renal response to pth infusion.	the renal responses to pth infusion were compared in two age groups of healthy subjects. basal nephrogenous cyclic amp (ncamp) was higher (1.68 +/- 0.74 vs. 0.97 +/- 0.50 nmol/dl gf; p less than 0.05) and tmpo4/gfr was lower (0.93 +/- 0.21 vs. 1.16 +/- 0.14 mmol/liter; p less than 0.025) in 10 elderly subjects compared with 12 young adults. creatinine clearance was decreased in the elderly (84.8 +/- 25.7 vs. 144.7 +/- 43.2 ml/min; p less than 0.005) and serum ipth tended to be increased (0.15 +/ ...	2009	2825933
alterations in tyrosine phosphorylation during the granulocytic maturation of hl-60 leukemia cells.	granulocytic maturation of hl-60 promyelocytic leukemia cells induced by dimethylsulfoxide has been shown to produce a decrease in cellular protein phosphotyrosine residues and increases in both tyrosine kinase and protein phosphotyrosine phosphatase activities (d. a. frank and a. c. sartorelli, biochem. biophys. res. commun., 140: 440-447, 1986). these changes have been shown to not be restricted to dimethylsulfoxide-induced differentiation, since similar changes occur in hl-60 cells initiated ...	2009	2825968
alterations in tyrosine phosphorylation during the granulocytic maturation of hl-60 leukemia cells.	granulocytic maturation of hl-60 promyelocytic leukemia cells induced by dimethylsulfoxide has been shown to produce a decrease in cellular protein phosphotyrosine residues and increases in both tyrosine kinase and protein phosphotyrosine phosphatase activities (d. a. frank and a. c. sartorelli, biochem. biophys. res. commun., 140: 440-447, 1986). these changes have been shown to not be restricted to dimethylsulfoxide-induced differentiation, since similar changes occur in hl-60 cells initiated ...	2009	2825968
modifications of dna-gyrase and of permeability in a norfloxacin-resistant clinical isolate of providencia stuartii.	we obtained a clinical isolate of providencia stuartii showing a high level of resistance to norfloxacin and to other 4-quinolones, whose target is the enzyme dna-gyrase. this strain showed resistance also to beta-lactam and aminoglycoside antibiotics. in order to detect modification of dna-gyrase, we performed supercoiling assays in vitro in presence of norfloxacin and ciprofloxacin. furthermore, outer membrane proteins, which are involved in permeability mechanisms, were analyzed on sds-polyac ...	1987	2826973
purification, characterization, and genetic organization of recombinant providencia stuartii urease expressed by escherichia coli.	recombinant urease from providencia stuartii has been expressed in and purified from escherichia coli, and the genetic organization of the structural genes has been determined. urease expression was induced by urea and repressed by nitrogen-rich components in the medium. the urease protein was purified 331-fold by deae-sepharose, phenyl-sepharose, mono-q, and phenyl-superose chromatographies with a 7.3% yield. the enzyme possessed a km for urea of 9.3 mm and hydrolyzed urea at a vmax of 7,100 mu ...	1988	2834333
norfloxacin resistance in providencia stuartii: modifications in dna-gyrase and permeability.		1988	2837244
proteus mirabilis urease: genetic organization, regulation, and expression of structural genes.	proteus mirabilis, a cause of serious urinary tract infection, produces urease, an important virulence factor for this species. the enzyme hydrolyzes urea to co2 and nh3, which initiates struvite or apatite stone formation. genes encoding urease were localized on a p. mirabilis chromosomal dna gene bank clone in escherichia coli by deletion analysis, subcloning, bal31 nuclease digestion, transposon tn5 mutagenesis, and in vitro transcription-translation. a region of dna between 4.0 and 5.4 kilob ...	1988	2841283
enzymatic degradation of urinary indoxyl sulfate by providencia stuartii and klebsiella pneumoniae causes the purple urine bag syndrome.	the etiology of the purple urine bag syndrome (pubs), in which the urinary catheter bag of some elderly patients develops intense purple coloration, was studied. the purple was found to be a mixture of indirubin dissolved in the plastic and indigo on its surface. six patients with pubs were studied, and providencia stuartii was isolated from the urine of five and klebsiella pneumoniae was isolated from the urine of one. these strains produced indigo in 7.9 mm indoxyl sulfate-containing agar. one ...	1988	2846640
inactivation of biofilm bacteria.	the current project was developed to examine inactivation of biofilm bacteria and to characterize the interaction of biocides with pipe surfaces. unattached bacteria were quite susceptible to the variety of disinfectants tested. viable bacterial counts were reduced 99% by exposure to 0.08 mg of hypochlorous acid (ph 7.0) per liter (1 to 2 degrees c) for 1 min. for monochloramine, 94 mg/liter was required to kill 99% of the bacteria within 1 min. these results were consistent with those found by ...	2010	2849380
biological and pathological consequences of feline infectious peritonitis virus infection in the cheetah.	an epizootic of feline infectious peritonitis in a captive cheetah population during 1982-1983 served to focus attention on the susceptibility of the cheetah (acinoyx jubatus) to infectious disease. subsequent observations based upon seroepidemiological surveys and electron microscopy of fecal material verified that cheetahs were indeed capable of being infected by coronaviruses, which were antigenically related to coronaviruses affecting domestic cats, i.e. feline infectious peritonitis virus/f ...	1988	2849387
malignant fibrous histiocytoma in keratosis, ichthyosis, and deafness syndrome.		2010	2849613
age-dependent changes in murine protein kinase and protease enzymes.	hormone responsiveness is mediated by signal transduction mechanisms involving second messengers, such as camp and ca2+, which regulate reversible changes in the phosphorylation state of proteins. during senescence individuals frequently exhibit a diminished responsiveness to hormones. we examined changes in enzymes involved in protein phosphorylation reactions that might account for this decreased adaptiveness in old mice, and observed the following post-maturational changes: (1) camp-dependent ...	2010	2852280
cytomegalovirus infection in fifty-two renal transplant recipients.		1987	2856277
synthesis of the nuclear protein cyclin does not correlate directly with transformation in quail embryo fibroblasts.	the synthesis of the nuclear protein 'cyclin' (mw 36 000) has been analysed in several virus-transformed quail embryo fibroblasts (qef) by means of quantitative two-dimensional gel electrophoresis. our studies revealed that the synthesis of cyclin does not correlate directly with cell transformation, but with cell proliferation.	2010	2857125
providencia stuartii: a search for its natural habitat.	a selective differential medium has been used to search for providencia stuartii in sewage, sewage contaminated natural waters and the faeces and skin of a small population of healthy non-hospitalized males. colonization of 12 male patients with long-term indwelling bladder catheters and the general environment of the spinal injury unit was also examined. providencia stuartii was not isolated from the non-hospital samples, but colonization of the urine (two patients) faeces (five patients) and s ...	1985	2862199
[physiological and pharmacologic studies of the adrenal medulla by the measurement of plasma catecholamine levels].	the new techniques for the assay of the plasma catecholamines: noradrenaline, dopamine and, most importantly, adrenaline, because of their sensitivity and precision, have provided new information about the physiology and the pharmacology of the adrenal medulla in animals and in man. the most effective of these new techniques are the radioenzymatic techniques. the activation of the adrenal medulla in the dog or the rat appears to be frequency-dependent by maintaining a fixed concentration ratio i ...	1985	2863423
measles vaccination in children attending day-care centres.		2010	2863672
pharmacodynamic interaction between midazolam and a specific benzodiazepine antagonist in humans.	the pharmacodynamic interaction between midazolam and the specific benzodiazepine antagonist ro 15-1788 has been investigated in six healthy male volunteers. hypnotic steady-state concentrations of midazolam (55 +/- 11 ng/ml; mean +/- sd) have been achieved rapidly by an intravenous bolus of 0.07 mg/kg and maintained by an individual but constant infusion rate of 0.025 to 0.04 mg/kg/hr for eight hours. following a two-hour control period, the antagonist (2.5 mg) or the solvent were injected doub ...	2010	2865275
drug metabolism and actions in the aged.		2009	2866941
bacteriophage d: an incd group plasmid-specific phage.	the existence of the plasmid incompatibility group d was reaffirmed as a result of compatibility experiments done on plasmids r687, r711b, r778b and r840 which were previously tentatively accepted as constituting the group. the group was further delineated by the isolation of a phage, phage d, which adsorbed specifically to incd plasmid-encoded pili produced by escherichia coli k12 strains and strains of salmonella typhimurium, proteus morganii and klebsiella oxytoca harbouring one of these plas ...	1985	2870129
activities in nursing ethics: local, national, international.		2010	2876421
survey of multiply resistant providencia stuartii in a chronic care unit.	providencia stuartii was cultured over a 4-year period from the urinary tract, throat, perineum, axilla and stools of patients in a long-term chronic care unit, the most common site of colonization being the urinary tract. a total of 17 patients had prov. stuartii bacteraemia and manipulation of the urinary tract preceded bacteraemia in 10 cases. eighty-two per cent of the patients had long-term urinary tract colonization from 1 month to 4 years. although most isolates were resistant to all amin ...	1987	2883227
a human hepatoma cell line expresses a single-chain form of gamma-glutamyl transpeptidase.	mammalian gamma-glutamyl transpeptidases characterized thus far have been shown to be heterodimeric glycoproteins. the two subunits are derived from a single-chain propeptide which, in the rat kidney, exhibits low transpeptidase activity (less than 2% of the dimeric enzyme). a human hepatoma-derived cell line, hep g2, expresses relatively high transpeptidase activity. the enzyme is primarily localized on the cell surface and exhibits catalytic properties similar to the dimeric human kidney and l ...	1987	2887558
the resistance of urinary tract pathogens to chlorhexidine bladder washouts.	isolates of providencia stuartii, pseudomonas aeruginosa, proteus mirabilis, klebsiella pneumoniae and streptococcus faecalis from urinary-tract infections in spinally-injured patients together with escherichia coli 10418 were challenged with chlorhexidine (200 mg l-1) in a model of a catheterized bladder under conditions which simulate the bladder washout technique. all species survived the antiseptic. organisms growing on the wall of the bladder model appeared to be particularly resistant and ...	1987	2888808
mr/k hemagglutination of providencia stuartii correlates with adherence to catheters and with persistence in catheter-associated bacteriuria.	providencia stuartii was the most prevalent bacterial species isolated, for one year, from weekly urine specimens from 51 long-term catheterized patients. significantly more strains causing bacteriuric episodes of long duration expressed mr/k (mannose-resistant/klebsiella-like) hemagglutination (74%) than did those causing episodes of short duration (26%; p = .004). isolates expressing mr/k hemagglutinin bound in higher numbers to catheter material (p = .023) than did those not expressing this h ...	1988	2891774
[20 years' experience with the charnley hip prosthesis. the wrightington experience].		2010	2897502
clinical and serological features of human herpesvirus-6 infection in three adults.	3 adult patients with serological evidence of human herpesvirus-6 (hhv-6) infection had mild, afebrile illnesses with nonspecific symptoms. in each case, the characteristic clinical feature was the presence of enlarged, bilateral, non-tender, anterior and posterior cervical nodes early in the illness which persisted for up to 3 months. hhv-6 igg antibody reciprocal titres of 160 to 2560 were found during acute infection, and decreased to a titre of 10 in 1 patient 3 years later. igm responses we ...	1988	2902266
detection of genomic variation in providencia stuartii clinical isolates by analysis of dna restriction fragment length polymorphisms containing rrna cistrons.	chromosomal dna from 26 strains of providencia stuartii isolated mainly in hospitals in the united kingdom and reference strains of p. stuartii, p. rustigianii, and proteus vulgaris were digested with the restriction endonucleases ecori and hindiii. after electrophoresis in agarose gels, the fragments were subjected to southern blot hybridization analysis with a biotin-labeled cdna probe transcribed from a mixture of 16s and 23s rrna from p. stuartii nctc 11800t. the pattern of bands (the rdna f ...	1988	2903175
cytologic features of endometrial papillary serous carcinoma.	endometrial papillary serous carcinoma (epsc) is an uncommon variant of endometrial carcinoma that histologically resembles ovarian serous carcinoma and has an aggressive clinical course. the cytomorphologic features of 17 patients with histologically confirmed epsc of the endometrium were reviewed and compared with those of 20 patients with histologically typical endometrial adenocarcinoma (tec). preoperative cervicovaginal papanicolaou smear results were available from 14 of the 17 patients wi ...	2010	2916358
vitellogenin induction by estradiol in channel catfish, ictalurus punctatus.	in oviparous vertebrates estrogens induce hepatic synthesis of vitellogenin (vg), a blood protein sequestered in vitellogenic oocytes and from which lipovitellin (lv) and phosvitin are derived. our objective was to identify vg in the channel catfish, ictalurus punctatus. an intraperitoneal injection of estradiol-17 beta into adult male fish induced a dose-dependent accumulation of a 150 kda protein (ep) in the plasma. ep was detectable in coomassie blue-stained polyacrylamide gels within 24 hr a ...	2010	2920897
timepieces. continuum.		2010	2932497
catecholamine release and potentiation of thromboxane a2 production by nicotine in the greyhound.	thromboxane a2 was generated by infusing arachidonic acid (2.5 micrograms ml-1) into an extra-corporeal circuit of blood withdrawn from anaesthetized dogs, and assayed on a blood-bathed bioassay cascade of porcine and bovine coronary artery strips, chick rectum and rat stomach strip. all tissues except chick rectum were treated with phentolamine and propranolol to abolish direct effects of catecholamines. the arachidonate-induced contractions of artery strips were abolished by a thromboxane synt ...	1986	2937502
[antigenic structure of the polysaccharide capsule of streptococcus pneumoniae strains isolated in leningrad 1978-1984].	the serotyping of 826 s. pneumoniae strains, isolated in conditionally diagnostic concentrations from the bronchial contents of patients with acute and chronic inflammatory pulmonary diseases during 1978-1984 in leningrad, was made. the study revealed the prevalence of serotypes and groups 6, 23, 9, 3, 19, 15 and the undulant character of fluctuations in their annual occurrence. the specific proportion of the prevailing serotypes of s. pneumoniae among the cultures isolated from patients with ac ...	1986	2944329
neurosecretion of human hypothalamic immunoreactive beta-endorphin: in vitro regulation by dopamine.	an in vitro perifusion system was used to investigate immunoreactive beta-endorphin (beta-end-i) release from adult human hypothalami in response to dopamine (da) and the da receptor antagonist haloperidol (hal). administration of a 1 microm pulse of da consistently elicited a mean (+/- se) 88 +/- 9% increase (p less than 0.05, n = 5) in beta-end-i release, whereas 1 microm hal had no effect. administration of 1 microm da during three perifusions in which 1 microm hal was added to the medium fai ...	1987	2951610
[changes in the biosynthesis, esterification and efflux of cholesterol in fibroblasts in culture from patients with niemann-pick disease type c].	cholesterol synthesis, esterification and efflux have been comparatively studied in control fibroblasts and in fibroblasts from patients with niemann-pick disease type c (npc). sterol synthesis was markedly increased in npc cells as compared to controls, either in whole medium or in medium devoid of lipoproteins. 14c-oleic acid incorporation into cholesteryl-esters was 2 to 3 fold reduced in npc cells, and esterification of 14c-exogenous cholesterol was dramatically (15-30 fold) decreased. acat ...	2010	2952228
preservation of cardiac function by coronary thrombolysis during acute myocardial infarction: fact or myth?		2010	2955027
inhibition of providencia stuartii cell envelope enzymes by chlorhexidine.	the possibility that chlorhexidine is a specific inhibitor of membrane bound bacterial adenosine triphosphatase (atpase) was addressed. the in-vitro susceptibilities of several providencia stuartii cell envelope enzymes, including atpase, to chlorhexidine were compared. the following concentrations of chlorhexidine were required to cause 50% inhibition of enzyme activity in preparations from chlorhexidine-sensitive strains (mic 50 mg chlorhexidine/l): atpase (160 mg/l), succinic dehydrogenase (g ...	1987	2956230
human milk-derived lactoferrin inhibits mitogen and alloantigen induced human lymphocyte proliferation.	purified lactoferrin (lf), isolated from human milk, was tested for its effect on human t-lymphocyte proliferative responses to phytohemagglutinin (pha) and to alloantigens in mixed lymphocyte culture. lf inhibited proliferation in both assays in a dose-dependent manner. the suppressive effect was not due to lf mediated cytotoxicity since washing cells that had been pre-incubated with lf restored their proliferative activity. lf was most effective in suppressing the pha response when added withi ...	1987	2963123
substrate specificity of nicotinamide methyltransferase isolated from porcine liver.	nicotinamide methyltransferase (ec 2.1.1.1) has been purified over 1300-fold from porcine liver. the enzyme is electrophoretically homogeneous, exhibiting a relative molecular mass of 27,000. in addition to acting on nicotinamide and close structural analogs such as thionicotinamide and 3-acetylpyridine, the enzyme actively accommodates poor analogs such as quinoline, isoquinoline, and 1,2,3,4-tetrahydroisoquinoline as methyl group acceptors. the enzyme may thus have the function of detoxicating ...	1988	2963591
[spinal intramedullary tumor with exophytic growth].	we experienced 22 cases of spinal intramedullary tumor, in which 5 cases were accompanied with exophytic growth. we discussed their clinical and radiological features, and therapeutic problems. concerning the locations of tumors with exophytic growth, the most common site was conus medullaris, accounting for 60% (3 cases). histopathological findings were astrocytoma in two cases, and in one case, mixed glioma, ependymoma and hemangioblastoma. in neurological observation, the most common initial ...	2010	2976124
principles of the diagnostic system 'orfèvre' for computerized analysis in radiology.		2010	2980470
evolution of an r plasmid from a cryptic plasmid by transposition of two copies of tn1 in providencia stuartii.	examination of a series of isolates of providencia stuartii collected over an 18 month period from a chronic-care patient at bristol royal infirmary revealed the emergence of resistance to carbenicillin. resistance was mediated by a 47 kb plasmid which transferred by conjugation to a plasmid-free strain of p. stuartii but not to escherichia coli. carbenicillin-sensitive isolates were either plasmid-free or contained a 36 kb cryptic plasmid. restriction endonuclease mapping of this plasmid showed ...	1985	2985741
an unusual case of wilson's disease.	a man of 61 with a 26-year history of progressive cerebellar ataxia was admitted to hospital. he was found to have chronic liver disease and died 22 days after admission. a diagnosis of hepatolenticular degeneration (wilson's disease) was supported by clinical investigations and confirmed at autopsy, when tissue copper studies were performed. several unusual features were present, including a unilateral kayser-fleischer ring, a hepatocellular carcinoma, peripheral neuropathy, pontine demyelinati ...	1985	2989971
rates of cholesterol synthesis and low-density lipoprotein uptake in the adrenal glands of the rat, hamster and rabbit in vivo.	the absolute rate of cholesterol acquisition from de novo synthesis and from receptor-dependent and receptor-independent low-density lipoprotein (ldl) uptake was determined in the adrenal glands of the rat, hamster and rabbit under in vivo conditions. the rate of incorporation of [3h]water into cholesterol in the adrenal gland was much higher in the hamster (1727 nmol/h per g) and rabbit (853 nmol/h per g) than in the rat (71 nmol/h per g). assuming that 23 atoms of 3h are incorporated into the ...	1985	2992599
anti-ischemic actions of a new thromboxane receptor antagonist during acute myocardial ischemia in cats.	thromboxane a2 (txa2) production increases significantly during acute myocardial ischemia. since txa2 induces platelet aggregation, coronary vasoconstriction, and has a direct cytolytic effect, thromboxane receptor antagonism would be expected to be beneficial in acute myocardial ischemia. thirty minutes after ligation of the left anterior descending coronary artery (lad) in anesthetized cats, the txa2 receptor antagonist bm-13,177 or its vehicle was given as a bolus injection at 20 mg/kg, follo ...	1985	3000159
[forestomach carcinoma and hepatoma induced in mice and rats by n-3-methylbutyl-n-1-methylacetonylnitrosamine (mambna)].	mambna is a new n-nitroso compound isolated from fusarium moniliforme-inoculated corn meal. in the present studies the carcinogenicity of mambna is shown by the induction of forestomach carcinomas and liver tumors in mice and rats following the gastric intubation of this compound. among 42 mice of kunming (km) stock treated with mambna (10-20 mg/week), 22 showed epithelial hyperplasia of the esophagus, 29 papillomas and 4 squamous carcinomas in the forestomach, and there were 6 liver adenomas an ...	1985	3004854
viral changes versus those due to electrocoagulation therapy.		1986	3008472
neuropathology of experimental 3-nitro-4-hydroxyphenylarsonic acid toxicosis in pigs.	twenty pigs were fed a diet containing 187.5 mg kg-1 of 3-nitro-4-hydroxyphenylarsonic acid (3-nitro). ten pigs were euthanized at intervals up to 29 days, 3-nitro was withdrawn from the diet of the remaining pigs on day 30, and these animals were subsequently euthanized at intervals up to 49 days after commencement of the experiment. a nervous syndrome characterized by clonic convulsive episodes inducible by exercise, developed at day 11. paraparesis was apparent at day 22 progressing to parapl ...	1986	3018982
the immune status of avian sarcoma virus-infected chickens as a determinant of sarcoma growth pattern and viral antigen expression.	patterns of sarcoma growth were compared in immune-suppressed (cyclophosphamide-treated) vs nonsuppressed avian sarcoma virus-infected chickens. sarcomas were initially induced in suppressed or nonsuppressed line fp chickens (donors) by wing web inoculation with clone 85, an avian sarcoma virus encoding an envelope glycoprotein that is non-antigenically cross-reactive with endogenous viral glycoprotein. sarcoma tissue from these donors was then implanted in the wing webs of suppressed or nonsupp ...	1987	3033080
clinical correlates of bacteremia in a veterans administration extended care facility.	little is known about bacteremia in long-term care facilities. we have conducted a retrospective study during a 12-month period analyzing the clinical correlates of bacteremia in 533 chronically institutionalized, predominantly male patients, with an average age of 69 years. thirty-four men had forty-two bacteremic illnesses during this period. the incidence rate was 0.30 episodes per 1000 patient care days, and the mortality rate was 21%. the urinary tract was the most frequently identified tis ...	1988	3042843
[ultrasonics and directional doppler. study of superficial phlebitis of the lower extremities].	the objective of the study was to evaluate the usefulness of ultrasonic methods: ultrasonography and doppler c.w. in the diagnosis of superficial varicose phlebitis. especially, measurement of the venous pressure (v.p.) at the posterior tibial (p.t.) and the greater saphenous vein (g.s.v.) in clino and orthostatism, have proved to be useful. in ten cases, one patient with a varicose in the thigh, was also found to have a femoral vein thrombosis secondary to a deep thrombus entering the junction. ...	2011	3043475
aaee minimonograph #32: the electrophysiologic examination in patients with radiculopathies.	a brief history of the evolution of radiculopathy as a clinical entity, and the use of electrodiagnostic studies to diagnose it, are provided. root anatomy and the concept of myotomes and dermatomes are reviewed, as is the pathophysiology of radiculopathy. the value and limitations of the various electrophysiologic procedures used in the diagnosis of radiculopathies are discussed, including motor and sensory nerve conduction studies, late responses, somatosensory evoked potentials, nerve root st ...	2010	3067085
aaee minimonograph #32: the electrophysiologic examination in patients with radiculopathies.	a brief history of the evolution of radiculopathy as a clinical entity, and the use of electrodiagnostic studies to diagnose it, are provided. root anatomy and the concept of myotomes and dermatomes are reviewed, as is the pathophysiology of radiculopathy. the value and limitations of the various electrophysiologic procedures used in the diagnosis of radiculopathies are discussed, including motor and sensory nerve conduction studies, late responses, somatosensory evoked potentials, nerve root st ...	2010	3067085
the 'bn2' gene, a regulator for the onset of chromosome condensation.		2011	3067728
the effect of mefloquine-artemether compared with quinine on patients with complicated falciparum malaria.	30 pairs of patients with complicated plasmodium falciparum malaria (with anaemia, hyperpyrexia, jaundice or more than 5% of erythrocytes parasitized) were studied. patients with cerebral signs and symptoms were excluded. one group of patients was treated with oral mefloquine (750 mg) and artemether (600 mg by injection, 200 mg initially and 100 mg every 12 h). the second group of patients was treated with quinine (10 mg/kg orally every 8 h for 7 d). all patients were admitted to hospital for 7 ...	1988	3075350
[mineralisation of dental plaque and caries prevention].		2011	3077804
providencia stuartii: a common cause of antibiotic-resistant bacteriuria in patients with long-term indwelling catheters.	the long-term-catheterized urinary tract may offer a particular niche to providencia stuartii, which is otherwise an uncommon clinical isolate. published accounts of bacteriuria in patients catheterized for long periods indicate that p. stuartii has often been found as frequently as familiar uropathogens such as escherichia coli, proteus mirabilis, enterococcus, and pseudomonas aeruginosa. as in most nosocomial infections, the frequency of isolation of a given species has commonly differed among ...	1986	3081988
resistance of providencia stuartii to chlorhexidine: a consideration of the role of the inner membrane.	spheroplasts of three strains of providencia stuartii (one sensitive, one moderately sensitive and one resistant to chlorhexidine) were induced by cefoxitin, glycine or a lysozyme-tris-edta combination, and their susceptibility to chlorhexidine-induced lysis investigated. maximum lysis of spheroplasts occurred at a low (2.5-5 micrograms/ml) concentration of chlorhexidine and was greatest with the most sensitive strain, pv2. the possible role of the inner membrane in chlorhexidine resistance is c ...	1986	3087933
data entry errors in computerized nutritional calculations.		2011	3088246
expression of cellulase genes in rhodobacter capsulatus by use of plasmid expression vectors.	broad-host-range plasmid vectors were constructed for expression of heterologous genes in the photosynthetic bacterium rhodobacter capsulatus. these plasmids utilize an rk2-derived replicon for maintenance and conjugative transfer and the r. capsulatus rxca promoter to obtain transcription of genes within appropriately positioned dna fragments. the expression vectors were used to obtain synthesis of endoglucanase and exoglucanase in r. capsulatus from cellulase genes present on exogenously deriv ...	1986	3090019
do clinical microbiology laboratories report complete bacteriology in urine from patients with long-term urinary catheters?	bacteriuria associated with long-term urinary catheters (those in place for greater than or equal to 30 days) appears to be the most common nosocomial infection in u.s. medical care facilities. this bacteriuria is polymicrobial and dynamic and accompanied by fevers, catheter obstructions, bacteremias, and deaths. we compared the reporting by our research laboratory of bacteria present in urine from long-term-catheterized nursing home patients with that by two commercial laboratories. the commerc ...	1986	3093528
reversal of the surface effects of chlorhexidine diacetate on cells of providencia stuartii.	chlorhexidine diacetate (cha) increased the hydrophobicity of the cell surface of cells of three strains of providencia stuartii. removal of at least some of the cha from the cells by washing them with an appropriate antidote partially reversed the hydrophobicity-increasing action of the biguanide. the effects of other treatments on cell surface hydrophobicity were examined with these strains and, for comparison, with two strains each of escherichia coli and pseudomonas aeruginosa: ethylenediami ...	1986	3100485
[economic efficacy of hygienic recommendations in regional planning].		2011	3106168
biosynthesis and processing of platelet gpiib-iiia in human megakaryocytes.	platelet membrane glycoprotein iib-iiia forms a calcium-dependent heterodimer and constitutes the fibrinogen receptor on stimulated platelets. gpiib is a two-chain protein containing disulfide-linked alpha and beta subunits. gpiiia is a single chain protein. these proteins are synthesized in the bone marrow by megakaryocytes, but the study of their synthesis has been hampered by the difficulty in obtaining enriched population of megakaryocytes in large numbers. to examine the biosynthesis and pr ...	1987	3108266
[regulation of milk intake in young ruminants].	we studied the influence of the three main nutritive components of milk - saccharides, fat and amino acids - on milk intake in suckling lambs and on the role of insulin as a key metabolic hormone for the regulation of milk intake. the intake was slowed down after p.o. administration of milk fat (p less than 0.05), after i. v. administration of methionine (p less than 0.001) and after p. o. administration of glucose, lactose (p less than 0.01, p less than 0.001) and sorbitol (p less than 0.001). ...	1987	3109104
nosocomial infectious balanoposthitis in neutropenic patients.	we have reported balanoposthitis as a source of fever and bacteremia in two neutropenic uncircumcised patients. the etiologic organisms were pseudomonas aeruginosa in one case and providencia stuartii in the other. in one patient, the diagnosis was delayed by the presence of a condom catheter. this emphasizes the importance of personal hygiene in uncircumcised men about to undergo immunosuppressive therapy, and the need for judicious use of condom catheters in such patients.	1987	3110971
oesophageal pain exacerbated by propranolol.		2011	3113570
[andrological abnormalities in internal diseases and following drug therapy].	in the present paper the following non-endocrine internal diseases are discussed: liver cirrhosis, diabetes, chronic renal failure and morbus crohn. in alcoholic liver patients under fifty, hypospermia and oligozoospermia can be observed. the hormone assays showed moderately increased fsh- and lh-values in the serum; prolactin, testosterone and estradiol remained normal. an increased binding of testosterone to shbg is supposed, and the androgen deficiency symptoms are considered to be due to the ...	2011	3115148
inactivation of alanine racemase by beta-chloro-l-alanine released enzymatically from amino acid and peptide c10-esters of deacetylcephalothin.	the reactions of a set of amino acid and peptidyl c10-esters of deacetylcephalothin (1-5) have been examined with purified enzymes in vitro. each of the compounds examined is a substrate for the escherichia coli tem-2 beta-lactamase, and enzyme-catalyzed hydrolysis of the lactam bond gives release of an amino acid or a peptidyl fragment from a cephem nucleus. 7 beta-(2-thienylacetamido)-3-[[(beta-chloro-l-alanyl)oxy]methyl]-3- cephem-4-carboxylate (4) gives time-dependent inactivation of e. coli ...	1987	3118951
[a case of recurrent epipharyngeal cancer showing complete disappearance following suppository administration of tegafur (sunfural rectal capsules)].	a 55-year-old woman was diagnosed as having epipharyngeal cancer, characterized by t2n1m0 and poorly differentiated squamous cell carcinoma. she was treated by radiotherapy (primary site: 65 gy, neck: 75 gy) and the tumor completely disappeared. however, 4 months later, the tumor recurred in the epipharynx. tegafur in the form of a suppository (sunfural rectal capsules, 750 mg) was given once a day. during the course of epipharyngoscopic follow-up the tumor almost totally disappeared at a dose o ...	2011	3122667