Publications
| Title | Abstract | Year Filter | PMID(sorted ascending) Filter |
|---|
| a polymorphic microsatellite marker in the human p55 tnf receptor, cd120a. | we provide characterization of a highly polymorphic dinucleotide repeat in the human tnf-receptor 1 gene (tnfr1, tnfrp55, cd120a). we have observed 11 alleles at this locus in individuals from the west of scotland. in a panel of healthy, unrelated individuals from the west of scotland (n = 143), the overall heterozygosity was 68%, indicating the potential usefulness of these markers in immunogenetic studies. | 2000 | 11196717 |
| frederick knox, younger brother and assistant of dr robert knox: his contribution to "knox's catalogues". | analysis of the material written in the two manuscript volumes known as the "old" and "new" knox catalogues has revealed that most of their contents are in the hand of frederick knox, younger brother of dr robert knox. frederick was employed by dr knox as his research assistant, and prepared detailed lists of the items in his brother's museum collection. he also dissected and prepared human and non-human specimens, many of which were described by dr knox in his numerous publications. as relative ... | 2001 | 11242743 |
| use of confidential hiv data helps convict former prisoner. | 2001 | 11250838 | |
| longitudinal cohort study of childhood iq and survival up to age 76. | to test the association between childhood iq and mortality over the normal human lifespan. | 2001 | 11290633 |
| an outbreak of e. coli o157 infection with evidence of spread from animals to man through contamination of a private water supply. | an outbreak of e. coli o157 infection occurred in the highland region of scotland in the summer of 1999. the source of the outbreak was traced to an untreated private water supply. all six cases identified arose in visitors to the area, and most had very limited exposure to the contaminated water. permanent residents on the same supply were unaffected. the e. coli o157 isolates from the water, sheep faeces collected from around the source and the human stool samples were indistinguishable using ... | 2001 | 11293673 |
| prevalence of antibodies to hepatitis c virus, hiv and human t-cell leukaemia/lymphoma viruses in injecting drug users in tayside, scotland, 1993-7. | the prevalence of blood-borne viruses in injecting drug users (idus) in tayside, scotland was determined by testing serum samples from idus who underwent attributable hiv antibody testing during 1993-7. the prevalence of antibodies to hiv was 29/802, (3.6%); to hepatitis c virus (hcv) 451/691, (65.3%); and to human t-cell leukaemia/lymphoma viruses type 1 and 2 (htlv) 0/679, (0.0%). the prevalence of hiv and hcv antibodies were higher in subjects over the age of 25 (p = 0.03 and p = 0.001, respe ... | 2001 | 11293687 |
| effect of combination therapy on immunologic progression of human immunodeficiency virus at a population level. | there is accumulating evidence from clinical trials and cohort studies that highly active antiretroviral combination therapy is effective at halting immunologic and clinical progression of human immunodeficiency virus (hiv). its impact at a population level is less well known because the regimes may be difficult to tolerate and compliance poorer. the authors make use of population data for almost all of the hiv-infected people in scotland in 1997 who were under clinical care and monitor their re ... | 2001 | 11323321 |
| the genomic organisation of the metabotropic glutamate receptor subtype 5 gene, and its association with schizophrenia. | the g-protein coupled metabotropic glutamate receptors (grms/mglurs) have been implicated in the aetiology of schizophrenia as they modulate the nmda response and that of other neurotransmitters including dopamine and gaba.(1-3) electrophysiological studies in grm subtype 5 knockout mice reveal, in one study, a sensorimotor gating deficit characteristic of schizophrenia and in another, a key rôle for this gene in the modulation of hippocampal nmda-dependent synaptic plasticity. in humans, grm5 l ... | 2001 | 11326300 |
| regional differences in semen quality in europe. | recent reports have indicated a decrease in semen quality of men in some countries, and suggested regional differences. a study was undertaken of semen samples from 1082 fertile men from four european cities (copenhagen, denmark; paris, france; edinburgh, scotland; and turku, finland). semen analysis was standardized, inter-laboratory differences in assessment of sperm concentration were evaluated, and morphology assessment centralized. lowest sperm concentrations and total counts were detected ... | 2001 | 11331653 |
| the gender imbalance among speech and language therapists and students. | speech and language therapy is still a predominantly female profession. this paper reports the numbers and percentages of males among the population of student speech and language therapists in the uk in 1999-2000. the numbers imply that there is no prospect of redressing the gender imbalance in the near future. information was gathered by means of a questionnaire to male speech and language therapy students and male therapists on the reasons for their career choice and their occupation-related ... | 2001 | 11340775 |
| a novel mutation in the keratin 13 gene causing oral white sponge nevus. | white sponge nevus (wsn) is an autosomal-dominantly inherited form of mucosal leukokeratosis. defects in keratins, proteins that form the stress-bearing cytoskeleton in epithelia, have been shown to cause several epithelial fragility disorders. recently, mutations in the genes encoding mucosal-specific keratins k4 and k13 were shown to be the underlying cause of wsn. we have studied a large scottish family with 19 persons affected by wsn in four generations. the k4 locus was excluded by genetic ... | 2001 | 11379896 |
| failure to confirm notch4 association with schizophrenia in a large population-based sample from scotland. | the notch4 gene was recently reported to be associated with schizophrenia based on tdt analysis of 80 british trios. the strongest evidence for association derived from two microsatellites. we genotyped both loci in a large sample of unrelated scottish schizophrenics and controls, but failed to replicate the reported association, finding instead that each putative schizophrenia-associated allele had a somewhat lower frequency in schizophrenics than in controls. | 2001 | 11381258 |
| permanent vegetative state and the law. | 2001 | 11511740 | |
| identification of polymorphisms within disrupted in schizophrenia 1 and disrupted in schizophrenia 2, and an investigation of their association with schizophrenia and bipolar affective disorder. | we have undertaken a search for polymorphic sequence variation within disrupted in schizophrenia 1 and disrupted in schizophrenia 2 (disc1 and disc2), which are both novel genes that span a translocation breakpoint strongly associated with schizophrenia and related psychoses in a large scottish family. a scan of the coding sequence, intron/exon boundaries, and part of the 5' and 3' untranslated regions of disc1, plus 2.7 kb at the 3' end of disc2, has revealed a novel microsatellite and 15 novel ... | 2001 | 11525420 |
| ethical approval for research involving geographically dispersed subjects: unsuitability of the uk mrec/lrec system and relevance to uncommon genetic disorders. | to assess the process involved in obtaining ethical approval for a single-centre study involving geographically dispersed subjects with an uncommon genetic disorder. | 2001 | 11579194 |
| the highlands and islands medical service: precursor of a state funded medical care system? | the highlands and islands of scotland cover a large area of the country and are sparsely populated. a series of man-made and natural disasters ensured that, early in the nineteenth century, they were also poverty stricken. it was gradually recognised that the degree of social deprivation was too severe for self-help and could only be alleviated from outside the area. this paper traces the use of state funds to support a medical service, from the first payments under the new poor law until the ou ... | 1996 | 11618765 |
| "de spermate hominis": a middle english poem on human embryology. [nat. libr. scotland, advocates' ms. 23.7.11]. | 1977 | 11639014 | |
| is it ethical to use patients to determine normal findings? | 1993 | 11643153 | |
| brave new world--nine months away? | reproductive technologies were the main theme of the aberdeen medical group day conference. among the topics discussed were the physician's right and duty to determine a couple's suitability for in vitro fertilization (ivf) and artificial insemination by donor, the ethical aspects of surrogate motherhood, the production of surplus embryos for use in ivf and research, and the legal status of embryos. speakers also addressed the issues involved in genetic screening, prenatal diagnosis, and discl ... | 1983 | 11644102 |
| donor insemination and the child. | 1993 | 11654720 | |
| edinburgh doctor struck off because of clinical-trial fraud. | 1997 | 11655095 | |
| fatal accident inquiry: death during research. | 1997 | 11657185 | |
| guidelines for researchers: patient information sheet and consent form. | 1999 | 11657984 | |
| scots will protect the mentally incapacitated: excerpts from the scottish executive white paper, making the right moves: rights and protection for adults with incapacity, 1999. | 1999 | 11657990 | |
| 10th international hugo mutation database initiative meeting, 19 april 2001, edinburgh, scotland. | the 10th international mutation database initiative meeting was held on april 19, 2001, in conjunction with the annual human genome meeting in edinburgh, scotland. key points of the meeting are described here. the bisc waystation was presented as an operational, viable beginning to the solution for the lack of centralized variation collection structures, with a number of possibilities, notably the bisc central database and hgbase, as candidates for storing the data. exploration of new avenues of ... | 2001 | 11668619 |
| sentinel practice-based survey of the management and health of horses in northern britain. | details of the management, feeding, level of activity and routine health care of horses in scotland and the five northernmost counties in england were recorded through a stratified random sample of horse owners who had responded to a previous survey. sixty-eight per cent of the horses were kept where their owners resided, and 32 per cent were kept away from the owner's home. more than 99 per cent were turned out to grazing for at least part of the year and 81 per cent were stabled for at least p ... | 2001 | 11678214 |
| hypermutability at a poly(a/t) tract in the human germline. | poly(a/t) tracts are abundant simple sequence repeats (ssrs) within the human genome. they constitute part of the coding sequence of a variety of genes, encoding polylysine stretches that are important for protein function. assessment of poly(a/t) tract stability is also used to identify microsatellite unstable colorectal cancers, which are characteristic of tumours defective in dna mismatch repair. despite their importance, little is known about the stability of poly(a/t) ssrs in the human germ ... | 2001 | 11691928 |
| regional differences in waiting time to pregnancy among fertile couples from four european cities. | a previous european study found a longer time to pregnancy (ttp) among fertile women from paris compared with women from other western european countries. a co-ordinated, cross-sectional study of pregnant couples from denmark (copenhagen), france (paris), scotland (edinburgh) and finland (turku) was therefore undertaken to assess differences in waiting ttp among couples from these cities. | 2001 | 11726598 |
| sperm morphological defects related to environment, lifestyle and medical history of 1001 male partners of pregnant women from four european cities. | recently, differences in semen quality have been found among the partners of pregnant women from four european cities: turku, copenhagen, edinburgh and paris. | 2001 | 11726600 |
| on being prepared: the influenza pandemic plan. | 2001 | 11732352 | |
| epidemiology and economic burden of viral hepatitis: an observational population based study. | to describe the epidemiology and estimate the health resource use of patients with viral hepatitis in tayside, scotland, using record linkage techniques. | 2002 | 11772975 |
| adults with incapacity (scotland) act 2000--excerpt. | 2000 | 11842859 | |
| hiv/aids. man 'deliberately infected' girlfriend. | 2001 | 11954226 | |
| longitudinal study of genital infection by herpes simplex virus type 1 in western scotland over 15 years. | 2002 | 12052804 | |
| every man his own farrier in australia: the origins and growth of a veterinary business in colonial new south wales. | the life and work is told of john pottie (1832-1908), a scotsman who graduated from edinburgh veterinary college in 1858. a year later, he contracted to provide veterinary care to a consignment of horses bound for australia. once there, he founded a firm that has survived to the present day, still marketing products that originated in his own veterinary remedies. john pottie brought with him a european tradition of livestock care and treatment that was epitomised in clater's title and book, ever ... | 2000 | 12068832 |
| william hunter's gravid uterus: the specimens and plates. | william hunter's collection of anatomical specimens of the pregnant uterus forms one of the finest displays in the anatomy museum at the university of glasgow. we were interested to know which specimens in the museum matched the plates in hunter's the anatomy of the human gravid uterus exhibited in figures (1774). in our investigation we were greatly assisted by teacher's catalogue of the anatomical and pathological preparations of dr william hunter (1900). thirteen specimens in the museum and o ... | 2002 | 12112351 |
| influenza and pneumococcal vaccine distribution and use in primary care and hospital settings in scotland: coverage, practice and policies. | a survey of the coverage, distribution and the factors associated with use of influenza and pneumococcal vaccines among general practitioners (gps) in primary care and in hospital settings was carried out in 53 general practices in scotland taking part in the 'continuous morbidity recording' (cmr) programme. the annual vaccine distribution increased substantially among 53 general practices from 1993 to 1999 and in scotland as a whole from 1984 to 1999. from the questionnaire, overall coverage wa ... | 2002 | 12113489 |
| combined ultrasound and biochemical screening for down's syndrome in the first trimester: a scottish multicentre study. | to evaluate the use of ultrasound measurements of fetal nuchal translucency (nt) obtained in a routine antenatal clinic setting in combination with appropriate biochemical markers as a first trimester screening test for down's syndrome. | 2002 | 12118646 |
| thomas stephenson, dsc, phc, frsedin, fcs: a man of parts. | 2002 | 12138907 | |
| daughter of charity. | members of religious orders, male and female, take the three vows of religion--poverty, chastity and obedience. to renounce one's rights to personal possessions, to sexual experience and family life and in determining one's own future may, on initial examination, appear somewhat negative. however, priests, brothers and nuns in religious orders, are encouraged to adopt a more positive attitude in taking the vows. by relinquishing their rights to personal property and to procreate, and by acceptin ... | 2001 | 12143447 |
| the mutation spectrum of hyperphenylalaninaemia in the republic of ireland: the population history of the irish revisited. | phenylketonuric and hyperphenylalaninaemic patients in the population of the republic of ireland were screened for mutations at the human phenylalanine hydroxylase (pah) locus. a composite data set for the island of ireland was generated by merging the findings of this study with extant data for northern ireland. analysis of this data on the basis of the four historic provinces (munster, leinster, connacht and ulster) revealed genetic diversity that is informative in terms of demographic forces ... | 2002 | 12173030 |
| sexual history and epstein-barr virus infection. | to determine the role of sexual contact in transmission of epstein-barr virus (ebv) and occurrence of infectious mononucleosis (im), a cross-sectional study was undertaken of ebv serologic testing and histories of im and sexual behavior among 1006 new students at edinburgh university. prevalence of ebv seropositivity was significantly greater among women (79.2%) than among men (67.4%; p<.001) and among those who had ever been sexually active (82.7%) than among those who had not (63.7%; p<.001). ... | 2002 | 12198605 |
| survival in trisomy 13 and trisomy 18 cases ascertained from population based registers. | 2002 | 12205124 | |
| hierarchical statistical modelling of influenza epidemic dynamics in space and time. | an infectious disease typically spreads via contact between infected and susceptible individuals. since the small-scale movements and contacts between people are generally not recorded, available data regarding infectious disease are often aggregations in space and time, yielding small-area counts of the number infected during successive, regular time intervals. in this paper, we develop a spatially descriptive, temporally dynamic hierarchical model to be fitted to such data. disease counts are ... | 2002 | 12228886 |
| family size and unemployment in a multiply deprived urban area. | 1978 | 12262702 | |
| scottish emigration in the 1980s: a migration channels approach to the study of skilled international migration. | "british emigration is now dominated by skilled transient movements rather than traditional settler emigration movements. this switch requires new frameworks for migration analysis. a migration channels approach is advocated with attention focused on the roles of the internal labour markets of multi-national companies, international recruitment agencies and international skill transfers by small- and intermediate-sized companies in moulding contemporary skilled migration. the migration proces ... | 1990 | 12283049 |
| the sex ratio of human births related to maternal age. | data from the annual reports of the registrar-general for england an d wales (1939-1947) and for scotland (1939-1947) were examined to determine the relationship of sex ratio to maternal age. sex ratios of total births and live births decrease with maternal age; sex ratios of stillbirths increase. the increase in the sex ratio of stillbirths with maternal age accounts for the difference between live births and total births. the decrease in the sex ratio of total births with maternal age may b ... | 1950 | 12332354 |
| age and human reproduction. | records of single 1st births to married women resident to aberdeen scotland, were examined to determine the relationship between age and reproduction. general significance of age differences are as follows: 1) the proportion of primiparae 40 years or older is 15% of the population; 2) women from educated classes postpone marriage and childbearing until economic stability has been obtained: 3) physical health and height are correlated, taller (and usually older) primiparae are in better health ... | 1958 | 12332401 |
| survey of a scottish diabetic clinic: a study of the etiology of diabetes mellitus. | certain features of a group of 1309 diabetics were studied. the group was considered representative of scottish diabetics since the sex distribution of cases corresponded to the sex distribution of deaths from diabetes recorded in the official mortality statistics for scotland. evidence is presented which justifies the use of scottish mortality statistics for this purpose. a study of the incidence of diabetes in 413,110 scottish recruits (male and female) suggested that in the general populat ... | 1949 | 12339641 |
| victorian values and the fertility decline: the case of scotland. | the author examines the final phase of the demographic transition in scotland during the late nineteenth century. particular attention is given to explanations developed by joseph banks concerning the fertility decline in england and wales. banks's analysis is reevaluated by applying it to data for scotland. no clear pattern of fertility by occupation is found. it is suggested instead that both family size limitation and emphasis on higher education were results of value reorientations. | 1986 | 12341337 |
| interregional migration in an extended input-output model. | "this article develops a two-region version of an extended input-output model that disaggregates consumption among employed, unemployed, and inmigrant households, and which explicitly models the influx into a region of migrants to take up a proportion of any jobs created in the regional economy. the model is empirically tested using real data for the scotland (uk) regions of strathclyde and rest-of-scotland. sets of interregional economic, demographic, demo-economic, and econo-demographic mult ... | 1990 | 12342779 |
| modelling human immunodeficiency virus infection and acquired immune deficiency syndrome cases in scotland: data sources, prior information and bayesian estimation. | "the paper describes the methodology developed to carry out predictions of the acquired immune deficiency syndrome (aids) epidemic in scotland. information on the human immunodeficiency virus (hiv) epidemic comes from formal case reports of aids cases and hiv positive tests, reports from surveillance schemes and from special studies. these sources of information, up to the end of 1994, are reviewed.... a simple model of the hiv epidemic in scotland is proposed and the information is summarized ... | 1998 | 12348726 |
| human bedbug infestation of a domestic cat. | 2002 | 12356240 | |
| the annual societal cost of alcohol misuse in scotland. | to estimate the annual socioeconomic burden imposed by alcohol misuse on scottish society. | 2002 | 12381241 |
| susceptibility to varicella-zoster virus in applicants for nurse training in scotland. | we investigated the immunity to varicella-zoster virus (vzv) of a cohort of applicants for nurse training and determined the relationship between immune status and history of chickenpox or shingles based on a self-completed questionnaire. three hundred and fifty-six applicants for nurse training were enrolled at an occupational health department in nhs scotland and 96% were immune to vzv. the positive predictive value of a history of vzv infection for seropositivity was 98% (286/292). the negati ... | 2002 | 12434695 |
| an eight-month study of a population of verocytotoxigenic escherichia coli (vtec) in a scottish cattle herd. | strains of verocytotoxin-producing escherichia coli (vtec) from scottish beef cattle on the same farm were isolated during four visits over a period of eight months. characteristics of these strains were examined to allow comparisons with strains of vtec associated with human infection. | 2002 | 12452950 |
| human case of ebl type 2 following exposure to bats in angus, scotland. | 2002 | 12498413 | |
| management of ectopic pregnancy in a scottish teaching hospital: implications for training. | an audit was undertaken to assess the management of 50 consecutive women with an ectopic pregnancy at a teaching hospital in scotland. the ectopic pregnancy was removed laparoscopically in 62% and of these women 80% were discharged home on the first postoperative day. in a minority of patients, elements of substandard care were identified including failure to operate when the ectopic pregnancy had been visualised on ultrasound or in the presence of static hcg levels in patients with an empty ute ... | 2002 | 12521708 |
| pesticide firms ask to use human data to assess safety. | 2003 | 12529604 | |
| the assessment of the amount of fat in the human body from measurements of skinfold thickness. 1967. | 2003 | 12572562 | |
| investigation of human infections with salmonella enterica serovar java in scotland and possible association with imported poultry. | pfge analysis of s. java strains (29 from humans, 30 from poultry meat) showed two major clusters. all isolates from poultry imported from the netherlands belonged to cluster a, which also comprised 10 human isolates. thirty-one of the 37 isolates in this cluster had an identical javx1 pattern, similar to the x8 profile of a particular s. java clone predominant in poultry production in several european countries. cluster b comprised 19 human isolates and two poultry isolates of unknown origin. t ... | 2003 | 12631973 |
| real-time modelling of influenza outbreaks--a linear regression analysis. | seasonal outbreaks of influenza exert a considerable burden on health services, and are notorious for their variability from year to year. making use of historical data from the scottish sentinelle surveillance since 1972, a potential candidate model has been derived based on simple linear regression. it was applied with a measure of success in the 1999-2000 winter season. | 2002 | 12631985 |
| long-term study of antibody response and injection-site effects of oil adjuvants in atlantic halibut (hippoglossus hippoglossus l). | atlantic halibut were injected intraperitoneally with human gamma globulin suspended in either phosphate buffered saline, freunds complete adjuvant or montanide isa711 to test the long-term effects of adjuvants. every month for 12 months up to five animals from each group were sampled. the peritoneal cavity was examined and the adhesion level scored on an arbitrary scale. serum was also collected and analysed by elisa for antibodies to human gamma globulin. results show that whilst fca produced ... | 2003 | 12657538 |
| acceptability and uptake of a community-based flu immunisation programme. | to evaluate a community based influenza immunisation programme in terms of patients' and primary care professionals' satisfaction and uptake of immunisation. | 2001 | 12664727 |
| the scottish molecular genetics consortium--15 years on. | remarkable advances have been made in recent years in our knowledge of the human genome. genes for disorders such as huntington disease, cystic fibrosis and duchenne muscular dystrophy have been mapped and mutations identified. simple molecular tests are now available for the diagnosis of these and many other conditions. as a result, in the last 15 years the whole new field of molecular pathology has been introduced to the health service of the united kingdom and now there are nearly 40 diagnost ... | 2002 | 12664773 |
| the gene for hmsn2c maps to 12q23-24: a region of neuromuscular disorders. | hereditary motor and sensory neuropathy type 2c (hmsn2c, charcot-marie-tooth 2c [cmt2c]) is an autosomal dominant motor and sensory neuropathy involving limb, diaphragm, vocal cord, and intercostal muscles. | 2003 | 12682323 |
| professional advantage and public health: british veterinarians and state veterinary services, 1865-1939. | at the beginning of the twentieth century, municipal authorities in england and wales, and in scotland, began to develop systems of veterinary public health which encompassed both the welfare of animals and the safety of meat and milk intended for human consumption. this paper examines the motives behind veterinary attempts to extend the integration of human and animal health considerations within the public health framework in the inter-war period. in 1938 the ministry of agriculture implemente ... | 2003 | 12688295 |
| the threat of climate change to freshwater pearl mussel populations. | changes in climate are occurring around the world and the effects on ecosystems will vary, depending on the extent and nature of these changes. in northern europe, experts predict that annual rainfall will increase significantly, along with dramatic storm events and flooding in the next 50-100 years. scotland is a stronghold of the endangered freshwater pearl mussel, margaritifera margaritifera (l.), and a number of populations may be threatened. for example, large floods have been shown to adve ... | 2003 | 12691490 |
| anaesthetists' non-technical skills (ants): evaluation of a behavioural marker system. | non-technical skills are critical for good anaesthetic practice but are not addressed explicitly in normal training. realization of the need to train and assess these skills is growing, but these activities must be based on properly developed skills frameworks and validated measurement tools. a prototype behavioural marker system was developed using human factors research techniques. the aim of this study was to conduct an experimental evaluation to establish its basic psychometric properties an ... | 2003 | 12697584 |
| william porterfield (ca. 1696-1771) and his phantom limb: an overlooked first self-report by a man of medicine. | early reports of phantom limbs by ambroise paré and rené descartes were based on second- or third-hand descriptions provided by amputees. william porterfield (ca. 1696-1771) was a prominent scottish physician and was possibly the first man of medicine to write about his experiences after having a leg amputated. porterfield was an authority on vision; he devised the first optometer and examined accommodation after cataract operations. rather than using the phenomenon of a phantom limb to question ... | 2003 | 12699565 |
| henry wade (1876-1955) and cancer research: early years in the life of a pioneer of urological surgery. | this paper describes the microscopic studies of human and experimental cancers made by henry wade during the years 1904-9. william ford robertson, his mentor, and wade claimed to have discovered a microbial cause of human cancer. the claim was at once fiercely disputed. wade turned to the investigation of a transmissible sarcoma of the dog, during which he demonstrated an early form of immune transplant rejection. he also undertook studies of hodgkin's disease. later in life, wade established ur ... | 2003 | 12717535 |
| first rotavirus, now astrovirus: the evolving benefits of rt-pcr. | we compared rt-pcr and a newly developed amplified eia for the detection of human astrovirus (hastv) in 48 stool samples taken from children of less than five years of age with gastroenteritis. the rt-pcr classified more samples as positive than the eia (18 versus 8). without sensitive diagnosis, infection control policies will be disadvantaged and the true economic burden of hastv underestimated. | 2003 | 12736977 |
| the identification of a us serviceman recovered from the holy loch, scotland. | during february and march 2000, human remains were recovered from the holy loch, scotland. police enquiries identified 13 males that had gone missing, presumed drowned in the holy loch or the adjoining lochs, over the previous 35 years. osteological examination of the remains established they were from a male, aged between 15 and 23 and 168-174 cm tall. this information eliminated ten of the known missing persons. dna profiles, both str and mitochondrial were generated from the remains and compa ... | 2003 | 12744005 |
| children's participation in healthcare in the uk--gesture, rhetoric, or real involvement? | in the united kingdom (england, wales, scotland, and northern ireland) children and their best interests are protected through a range of best practice initiatives, and legislation and guidance at country, national, european, and global levels. some of the recent commitment by the government may be the result of enlightened thinking, but some of it has resulted from the aftermath of at least two major healthcare incidents. this article reviews the uk's recent national and international efforts t ... | 2002 | 12744268 |
| a y chromosome census of the british isles. | the degree of population replacement in the british isles associated with cultural changes has been extensively debated. recent work has demonstrated that comparisons of genetic variation in the british isles and on the european continent can illuminate specific demographic processes in the history of the british isles. for example, wilson et al. used the similarity of basque and celtic y chromosomes to argue for genetic continuity from the upper palaeolithic to the present in the paternal histo ... | 2003 | 12781138 |
| the hydra, captain aj brock and the treatment of shell-shock in edinburgh. | 2003 | 12830809 | |
| genetic polymorphism of hla dr in a scottish population of patients with pars planitis. | human leucocyte antigen (hla) class ii influences the immunological susceptibility for a variety of diseases including many types of non-infectious intraocular inflammation. previous studies on north american patients with pars planitis, a subtype of intermediate uveitis, reported an increased prevalence of hla dr15 in this population. in contrast, two european studies could not find an association between hla dr2 or its allelic subtype dr15 and various forms of intermediate uveitis. we therefor ... | 2003 | 12841565 |
| women's health in midlife: findings from a british birth cohort study. | the medical research council's national survey of health and development (mrcnshd) is a prospective cohort study of 2547 women and 2815 men, a sample of all the births that took place in england, scotland and wales between 3-9 march 1946. it is one of the longest running large-scale studies of human development in the world, aiming to identify lifetime biological, social and psychological pathways to health and disease, from early life to ageing. a special study of women's health in midlife and ... | 2003 | 12844426 |
| frequency, viral loads, and serotype identification of enterovirus infections in scottish blood donors. | enteroviruses are non-enveloped, frequently pathogenic rna viruses infecting humans. infection is potentially transmissible through blood or blood component transfusion from donor in the viremic phase before seroconversion for antibody. to investigate the threat to blood safety from enteroviruses, a large-scale survey of frequency and levels of viremia in blood donors was conducted. study designs and methods: blood donations from scotland over a period of 22 calendar months were screened for ent ... | 2003 | 12869111 |
| infectious disease mortality in two outer hebridean islands: 1. measles, pertussis and influenza. | the purpose of the study was to examine changes in mortality from measles, pertussis (whooping cough) and influenza (all epidemic diseases) in harris and barra, two outer hebridean islands, from 1855 to 1990, and to compare the findings with those from scotland as a whole over the same period. it was also intended to relate changes in mortality to those in social and economic factors. | 2003 | 12881144 |
| changing epidemiology of hepatitis a: should we be doing more to vaccinate injecting drug users? | since 2001 there have been significant outbreaks of hepatitis a virus (hav) across south yorkshire, largely in intravenous drug users, and hav infection has been reported to be an increasing problem in england and scotland during this time. this paper reports a brief investigation to clarify current hav epidemiology in england and wales. the epidemiology of hav in england, but not yet wales, has recently changed. laboratory reports now show that most cases are occurring in young adults, mainly y ... | 2003 | 12889286 |
| fatal human rabies caused by european bat lyssavirus type 2a infection in scotland. | we wish to report the first recorded case of indigenous human rabies caused by a bat bite in the united kingdom in 100 years. this instructive case report highlights a number of key lessons: first, bites from insectivorous bats indiginous to the united kingdom can cause rabies in humans; second, rabies immunization is essential for bat-handlers, and postexposure treatment for rabies is essential for patients bitten by bats; third, patients able to give a history who present with acute flaccid pa ... | 2003 | 12905146 |
| maternal consumption of a high-meat, low-carbohydrate diet in late pregnancy: relation to adult cortisol concentrations in the offspring. | recent studies have linked maternal consumption of an unbalanced high-protein, low-carbohydrate diet in late pregnancy with raised adult blood pressure in the offspring. because high-protein diets stimulate the hypothalamic-pituitary-adrenal axis, we hypothesized that an unbalanced maternal diet might increase maternal cortisol levels, exposing the fetus to excess cortisol and programming lifelong hypersecretion of cortisol. we therefore measured fasting plasma cortisol concentrations in 251 sub ... | 2003 | 12915635 |
| the prevalence of haemochromatosis gene mutations in the west of scotland and their relation to ischaemic heart disease. | excess iron stores have been postulated to enhance the risk of ischaemic heart disease. this study aims to determine whether the two major mutations of the haemochromatosis (hfe) gene (c282y and h63d) are associated with ischaemic heart disease (ihd) or myocardial infarction (mi). | 2003 | 12923017 |
| foot and mouth epidemic reduces cases of human cryptosporidiosis in scotland. | in scotland, rates of cryptosporidiosis infection in humans peak during the spring, a peak that is coincident with the peak in rates of infection in farm animals (during lambing and calving time). here we show that, during the outbreak of foot and mouth disease (fmd) in 2001, there was a significant reduction in human cases of cryptosporidiosis infection in southern scotland, where fmd was present, whereas, in the rest of scotland, there was a reduction in cases that was not significant. we asso ... | 2003 | 12934196 |
| community pediatrics research. | increasing recognition of the complexity and importance of social determinants of child health has changed dramatically the scope, direction, and purpose of pediatric research. considered in the context of the evolving research on the role of the human genome in determining the functional status of children and adults, the increasing focus on the social determinants of health emphasizes the need for multidisciplinary collaboration in research endeavors. the changing roles of children and youths ... | 2003 | 12949348 |
| acute transverse myelopathy and echo-2 virus infection. | 1963 | 14072959 | |
| the genetic factor in dupuytren's disease. | 1963 | 14074318 | |
| thalassaemia in scots. | five cases of thalassaemia minor and 11 symptomless trait carriers have been detected in four scottish families, only one of which is known to have foreign ancestry. it is suggested that the condition is commoner than was once thought, and that the diagnosis should be considered in any patient with refractory hypochromic anaemia in which the red cells show increased osmotic resistance. | 1963 | 14076382 |
| the cla(caldwell) antigen: a new and rare human blood group antigen related to the mnss system. | 1963 | 14109962 | |
| an outbreak of meningitis due to echo virus type 4 in scotland, 1963. | 1964 | 14132659 | |
| laboratory diagnosis of echo type 9 virus infection. | 1964 | 14141575 | |
| infections by organisms of psittacosis/lymphogranuloma venereum group in the west of scotland. | 1964 | 14147769 | |
| cytogenetic studies in leucocytes on the general population: subjects of ages 65 years and more. | 1964 | 14175200 | |
| echo 9 virus infection and congenital malformations. | 1964 | 14198229 | |
| hereditary heinz-body anaemia, thrombocytopenia, and haemoglobinopathy (hb koeln) in a glasgow family. | 1964 | 14198723 | |
| family studies and the cause of congenital club foot. talipes equinovarus, talipes calcaneo-valgus and metatarsus varus. | 1964 | 14216453 | |
| characteristics of men with intermittent claudication. | 1965 | 14259702 | |
| familial incidence and geography in multiple sclerosis. | 1965 | 14289912 | |
| distribution of the abo and rhesus (d) blood groups in the north of scotland. | 1965 | 14313688 |