Publications
| Title | Abstract | Year Filter | PMID(sorted ascending) Filter |
|---|
| snap23-dependent surface translocation of leukotriene b4 (ltb4) receptor 1 is essential for nox2-mediated exocytotic degranulation in human mast cells induced by trichomonas vaginalis-secreted ltb4. | trichomonas vaginalis is a sexually transmitted parasite that causes vaginitis in women and itself secretes lipid mediator leukotriene b4 (ltb4). mast cells are important effector cells of tissue inflammation during infection with parasites. membrane-bridging snare (soluble n-ethylmaleimide-sensitive factor attachment protein receptor) complexes are critical for fusion during exocytosis. although t. vaginalis-derived secretory products (tvsp) have been shown to induce exocytosis in mast cells, i ... | 2017 | 27795355 |
| benefits of cervical cancer screening by liquid-based cytology as part of routine antenatal assessment. | to determine the prevalence of abnormal cervical cytology, as diagnosed using a liquid-based cytology technique, in pregnant women attending the antenatal care (anc) clinic at siriraj hospital. | 2016 | 27797261 |
| comparative protein structure modeling using modeller. | comparative protein structure modeling predicts the three-dimensional structure of a given protein sequence (target) based primarily on its alignment to one or more proteins of known structure (templates). the prediction process consists of fold assignment, target-template alignment, model building, and model evaluation. this unit describes how to calculate comparative models using the program modeller and how to use the modbase database of such models, and discusses all four steps of comparativ ... | 2016 | 27801516 |
| responding to a zoonotic emergency with multi-omics research: pentatrichomonas hominis hydrogenosomal protein characterization with use of rna sequencing and proteomics. | pentatrichomonas hominis is an anaerobic flagellated protist that colonizes the large intestine of a number of mammals, including cats, dogs, nonhuman primates, and humans. the wide host range of this organism is alarming and suggests a rising zoonotic emergency. however, knowledge on in-depth biology of this protist is still limited. similar to the human pathogen, trichomonas vaginalis, p. hominis possesses hydrogenosomes instead of mitochondria. studies in t. vaginalis indicated that hydrogeno ... | 2016 | 27828770 |
| associations between vaginal infections and potential high-risk and high-risk human papillomavirus genotypes in female sex workers in western kenya. | infection with and persistence of high-risk human papillomavirus (hr hpv) are the strongest risk factors for cervical cancer. little is known about the prevalence and role of concurrent sexually transmitted infections (stis) found in hpv-infected female sex workers (fsw) in africa. this study purports to test our a priori hypotheses that stis are associated with genotypes pertaining to the α-group species 9. the objectives were to determine the prevalence of bacterial vaginosis (bv), trichomonas ... | 2016 | 27836494 |
| mycoplasma genitalium and trichomonas vaginalis in france: a point prevalence study in people screened for sexually transmitted diseases. | mycoplasma genitalium and trichomonas vaginalis are common causes of sexually transmitted infections, but limited prevalence data are available in france. we aimed to evaluate the prevalence of m. genitalium and t. vaginalis infections and to assess prevalence by gender, age, sample collection sites and clinical symptoms. a multicentre collection of specimens was intended to obtain a nationwide overview of the epidemiology. | 2017 | 27836808 |
| auranofin inactivates trichomonas vaginalis thioredoxin reductase and is effective against trichomonads in vitro and in vivo. | trichomoniasis, caused by the protozoan parasite trichomonas vaginalis, is the most common, non-viral, sexually transmitted infection in the world, but only two closely related nitro drugs are approved for its treatment. new antimicrobials against trichomoniasis remain an urgent need. several organic gold compounds were tested for activity against t. vaginalis thioredoxin reductase (trxr) in cell-free systems as well as for activity against different trichomonads in vitro and in a murine infecti ... | 2016 | 27839893 |
| sti tests and proportion of positive tests in female sex workers attending local public health departments in germany in 2010/11. | in germany, local public health departments (lphd) are required to offer low-threshold access to confidential counselling and testing for sexually transmitted infections (sti) for sex workers. we collected data from lphd in germany to estimate the number of performed sti tests and the proportion of positive sti tests among attending female sex workers (fsw) in order to formulate recommendations for improving sti testing and care for fsw in germany. | 2016 | 27871264 |
| adenosine, but not guanosine, protects vaginal epithelial cells from trichomonas vaginalis cytotoxicity. | trichomonas vaginalis causes the most common non-viral sexually transmitted disease worldwide. the cytoadherence and cytotoxicity upon the vaginal epithelial cells are crucial for the infection. extracellular nucleotides are released during cell damage and, along with their nucleosides, can activate purinoceptors. the opposing effects of nucleotides versus nucleosides are regulated by ectonucleotidases. herein we evaluated the hemolysis and cytolysis induced by t. vaginalis, as well as the extra ... | 2017 | 27871906 |
| trichomoniasis in older individuals: a preliminary report from iran. | infection with trichomonas vaginalis is one of the most common sexually transmitted diseases (stds) in humans. the prevalence of infection in iran has been reported 0.009-8 % depending on deferent socio-cultural conditions. this study aimed to determine the frequency of t. vaginalis according to age in patients referred to clinics, hospitals and medical diagnostic laboratories in karaj city, iran. for this purpose, fifty positive samples were collected from july 2012 to june 2014 from clinics, m ... | 2016 | 27876991 |
| gentamicin versus ceftriaxone for the treatment of gonorrhoea (g-tog trial): study protocol for a randomised trial. | gonorrhoea is a common sexually transmitted infection which causes genital pain and discomfort; in women it can also lead to pelvic inflammatory disease and infertility, and in men to epididymo-orchitis. current treatment is with ceftriaxone, but there is increasing evidence of antimicrobial resistance which is reducing its effectiveness against gonorrhoea. a small, but increasing, number of patients have already been found to have highly resistant strains of gonorrhoea which has been associated ... | 2016 | 27881151 |
| menstrual cups and sanitary pads to reduce school attrition, and sexually transmitted and reproductive tract infections: a cluster randomised controlled feasibility study in rural western kenya. | conduct a feasibility study on the effect of menstrual hygiene on schoolgirls' school and health (reproductive/sexual) outcomes. | 2016 | 27881530 |
| in situ forming pluronic® f127/chitosan hydrogel limits metronidazole transmucosal absorption. | the objective of this work is to design topically-applied thermosensitive and mucoadhesive hydrogel containing metronidazole (mtz) for the treatment of trichomonas vaginalis infections. hydrogel composed of pluronic® f127 (20wt%), chitosan (1wt%) and metronidazole mtz (0.7wt%) mixture showed its ability to decrease by a factor 4 mtz flux and apparent permeability absorption through vaginal mucosa. the impact of hydrogel on transmucosal penetration of mtz was evaluated ex vivo on excised porcine ... | 2017 | 27890510 |
| clinical laboratory assessments for mycoplasma genitalium in a high-prevalence sexually-transmitted infection community reveal epidemiologic dichotomies with trichomonas vaginalis. | mycoplasma genitalium is an emerging agent of sexually-transmitted infection and is responsible for clinically-significant genital tract disease in both females and males. similar to scenarios recently experienced with the urogenital flagellate trichomonas vaginalis, an evolving molecular diagnostic reference standard based on transcription-mediated amplification allows for accurate detection of the organism, plus additional insight into disease epidemiology. areas covered. the basis for this ar ... | 2017 | 27894204 |
| quantitative real-time polymerase chain reaction for the diagnosis of mycoplasma genitalium infection in south african men with and without symptoms of urethritis. | this study was done to diagnose mycoplasma genitalium infection based on bacterial load in urine specimens from symptomatic and asymptomatic men. | 2017 | 27898565 |
| single-dose compared with multidose metronidazole for the treatment of trichomoniasis in women: a meta-analysis. | trichomonas vaginalis is the most common curable sexually transmitted infection worldwide. although the centers for disease control and prevention and the world health organization recommend a single 2-g dose of metronidazole for the first line of treatment for t. vaginalis among human immunodeficiency virus (hiv) negative women, high rates of repeat infections are found. the purpose of this meta-analysis was to compare treatment failure between single versus multidose metronidazole for the trea ... | 2017 | 27898571 |
| characterization of cyclin-dependent kinases and cdc2/cdc28 kinase subunits in trichomonas vaginalis. | cyclin-dependent kinases (cdks) have important roles in regulating key checkpoints between stages of the cell cycle. their activity is tightly regulated through a variety of mechanisms, including through binding with cyclin proteins and the cdc2/cdc28 kinase subunit (cks), and their phosphorylation at specific amino acids. studies of the components involved in cell cycle control in parasitic protozoa are limited. trichomonas vaginalis is the causative agent of trichomoniasis in humans and is the ... | 2017 | 27928981 |
| antiprotozoal effects of the tomato tetrasaccharide glycoalkaloid tomatine and the aglycone tomatidine on mucosal trichomonads. | the present study investigated the inhibitory effects of the commercial tetrasaccharide tomato glycoalkaloid tomatine and the aglycone tomatidine on three mucosal pathogenic protozoa that are reported to infect humans, cattle, and cats, respectively: trichomonas vaginalis strain g3, tritrichomonas foetus strain d1, and tritrichomonas foetus strain c1. a preliminary screen showed that tomatine at 100 μm concentration completely inhibited the growth of all three trichomonads. in contrast, the inhi ... | 2016 | 27934291 |
| epidemiology of trichomoniasis in south korea and increasing trend in incidence, health insurance review and assessment 2009-2014. | trichomoniasis, which is caused by trichomonas vaginalis, is one of the most common non-viral sexually transmitted infections; however, limited population-based data are available that describe patterns and trends of the disease. we summarized insurance claims of trichomoniasis cases reported during 2009-2014 to south korea health insurance review and assessment service. the average annual incidence in south korea was 276.8 persons per 100,000 population, and a substantial sex-associated variati ... | 2016 | 27936227 |
| the caatinga endemic manilkara rufula possesses remarkable activity against trichomonas vaginalis and tritrichomonas foetus. | tritrichomonas foetus infects the bovine urogenital tract, causing bovine trichomoniasis. significant economic losses may occur due to infertility and abortion among cattle. trichomonas vaginalis is the causative agent of trichomoniasis; the most common but overlooked non-viral sexually transmitted disease worldwide. human and bovine trichomoniasis present treatment restrictions and efforts to identify new alternatives are essential. the present study evaluated the anti-trichomonads activities o ... | 2017 | 27956086 |
| prevalence and associated factors of genital and sexually transmitted infections in married women of iran. | this study aimed to determine the prevalence of genital and sexually transmitted infections and its related factors in married women in iran. | 2016 | 27974960 |
| ginger (zingiber officinale) induces apoptosis in trichomonas vaginalis in vitro. | trichomoniasis is the most common sexually transmitted protozoan diseases in the worldwide. metronidazole is the choice drug for trichomoniasis treatment, however, metronidazole resistant trichomonas vaginalis (t.vaginalis) has been reported. natural products are the source of most new drugs, and zingiber officinale (ginger) is widely used ingredient in the traditional medicine. | 2016 | 27981254 |
| trichomonas vaginalis treated with boric acid in a metronidazole allergic female. | 2017 | 27984554 | |
| association between high risk human papillomavirus infection and co-infection with candida spp. and trichomonas vaginalis in women with cervical premalignant and malignant lesions. | human papillomavirus (hpv) is the necessary cause of cervical cancer. cervico-vaginal infection with pathogens like chlamydia is a likely cofactor. the interactions between hpv, trichomonas vaginalis (tv) and candida spp. are less understood, though inflammation induced by these pathogens has been demonstrated to facilitate oncogenesis. | 2017 | 27992790 |
| sexually transmitted diseases and infertility. | female infertility, including tubal factor infertility, is a major public health concern worldwide. most cases of tubal factor infertility are attributable to untreated sexually transmitted diseases that ascend along the reproductive tract and are capable of causing tubal inflammation, damage, and scarring. evidence has consistently demonstrated the effects of chlamydia trachomatis and neisseria gonorrhoeae as pathogenic bacteria involved in reproductive tract morbidities including tubal factor ... | 2017 | 28007229 |
| a study on the prevalence of genital trichomoniasis among female outpatients attending sexually transmitted infection clinic in a tertiary care hospital. | women with high-risk sexual behavior accounts for more than half of the sexually transmitted infection (sti) clinic attendees. the prevalence of trichomoniasis is as low as 5% in the general population to as high as 60% in high-risk population. this infection can pave the way to the acquisition of human immunodeficiency virus and other stis, vice versa and is even associated with cancer. | 2017 | 28042211 |
| prevalence of trichomonas vaginalis and candida albicans among brazilian women of reproductive age. | there are no studies assessing the simultaneous occurrence of candida albicans (c. albicans) and trichomonas vaginalis (t. vaginalis) in the primary health care in brazil. despite different conditions to establishment of each one, the co-detection of both has been reported by some authors in previous studies from other regions. | 2016 | 28050410 |
| a nonobstructive azoospermic patient with trichomonas vaginalis infection in testes. | 2017 | 28051042 | |
| epigenetics regulates transcription and pathogenesis in the parasite trichomonas vaginalis. | trichomonas vaginalis is a common sexually transmitted parasite that colonizes the human urogenital tract. infections range from asymptomatic to highly inflammatory, depending on the host and the parasite strain. different t. vaginalis strains vary greatly in their adherence and cytolytic capacities. these phenotypic differences might be attributed to differentially expressed genes as a consequence of extra-genetic variation, such as epigenetic modifications. in this study, we explored the role ... | 2017 | 28054438 |
| [nonviral sexually transmitted infections-epidemiology, clinical manifestations, diagnostic workup, therapy : part 3: treponemes, gardnerella and trichomonads]. | in germany, the reported syphilis prevalence has increased continuously since 2010, with a total of 6834 syphilis cases being reported in 2015. the largest increase of reported syphilis occurred in men who have sex with men (msm). the antibiotic agent of choice for treatment of syphilis is still penicillin. there are no penicillin-resistant treponema pallidum strains. alternatives are ceftriaxone and doxycycline. in germany, azithromycin is not approved for treatment of syphilis; however, therap ... | 2017 | 28058468 |
| topical tenofovir protects against vaginal simian hiv infection in macaques coinfected with chlamydia trachomatis and trichomonas vaginalis. | chlamydia trachomatis and trichomonas vaginalis, two prevalent sexually transmitted infections, are known to increase hiv risk in women and could potentially diminish preexposure prophylaxis efficacy, particularly for topical interventions that rely on local protection. we investigated in macaques whether coinfection with chlamydia trachomatis/trichomonas vaginalis reduces protection by vaginal tenofovir (tfv) gel. | 2017 | 28060011 |
| vulvovaginite : dépistage et prise en charge de la trichomonase, de la candidose vulvovaginale et de la vaginose bactérienne. | analyser les données probantes et formuler des recommandations quant au dépistage et à la prise en charge de la candidose vulvovaginale, de la trichomonase et de la vaginose bactérienne. | 2016 | 28063567 |
| multiple hpv infections in female sex workers in western kenya: implications for prophylactic vaccines within this sub population. | whilst the imputed role of high risk (hr) hpv infection in the development of cervical lesions and cancer has been established, the high number of hpv genotypes that female sex workers (fsw) harbour warrants that the synergistic effects of potential hr (phr) and hr hpv genotypes be elucidated to assess the potential impact of prophylactic vaccines. this population in kenya also harbours a number of other vaginal infections and stis, including bacterial vaginosis (bv), trichomonas vaginalis (tv) ... | 2017 | 28070215 |
| clinical performance of the solana® point-of-care trichomonas assay from clinician-collected vaginal swabs and urine specimens from symptomatic and asymptomatic women. | solana® (quidel) is a new rapid (<40 min.) point-of-care (poc) test for qualitative detection of trichomonas vaginalis (tv) dna. the assay has two steps: 1) specimen preparation, and 2) amplification and detection using isothermal helicase-dependent amplification (hda). the objective was to demonstrate the performance of solana for vaginal swabs and female urines based on comparison to wet mount and tv culture. performance was also compared to the aptima-tv assay. | 2017 | 28092466 |
| association between preterm labor and genitourinary tract infections caused by trichomonas vaginalis, mycoplasma hominis, gram-negative bacilli, and coryneforms. | preterm labor (ptl) is responsible for most cases of neonatal death. in most of these cases, the causes of ptl have not been established although several risk factors have been described. therefore, the aim of this study was to investigate risk factors for ptl before 37 gestational weeks among egyptian women. | 2017 | 28094234 |
| iron responsive-like elements in the parasite entamoeba histolytica. | in entamoeba histolytica, iron modulates virulence and gene expression via unknown regulatory mechanisms. the existence of a posttranscriptional iron regulatory system parallel to the ire/irp (iron-responsive element/iron regulatory protein) system in the protozoan trichomonas vaginalis has recently been reported. due to their evolutionary closeness and the importance of iron for growth and virulence in these protozoa, we hypothesized the existence of an ire/irp-like mechanism in e. histolytica. ... | 2017 | 28100304 |
| an evaluation study of the becton-dickinson probetec qx (bdqx) trichomonas vaginalis trichomoniasis molecular diagnostic test in two large, urban std services. | the bashh guidelines recommend molecular tests to aid diagnosis of trichomonas vaginalis (tv) infection; however many clinics continue to use relatively insensitive techniques (ph, wet-prep microscopy (wpm) and culture). our objectives were to establish a laboratory pathway for tv testing with the becton-dickinson qx (bdqx) molecular assay, to determine tv prevalence and to identify variables associated with tv detection. | 2017 | 28108699 |
| detection of sexually transmitted pathogens in patients with chronic prostatitis/chronic pelvic pain: a prospective clinical study. | in <10% of patients with prostatitis syndrome, a causative uropathogenic organism can be detected. it has been shown that certain organisms that cause sexually transmitted infections can also cause chronic bacterial prostatitis, which can be hard to diagnose and treat appropriately because prostatic samples obtained by prostatic massage are not routinely tested to detect them. we conducted a clinical study to determine the prevalence of chlamydia, mycoplasma, and trichomonas infection in 254 pat ... | 2017 | 28120647 |
| [investigation of in vitro metronidazole resistance in the clinical isolates of trichomonas vaginalis]. | trichomonas vaginalis, a flagellated, urogenital anaerobic protozoon is reported as an important cause of vaginitis with a global distribution. although metronidazole is the primary choice of drug for the treatment of trichomoniasis, the presence of resistant isolates from many different countries highlights the need of novel drugs for the treatment. many studies from turkey mostly dealing with the in vitro effects of compounds and natural products against t.vaginalis have been reported, however ... | 2016 | 28124960 |
| [investigation of the prevalence of trichomonas vaginalis among female syrian refugees with the complaints of vaginitis aged between 15-49 years]. | since the syrian civil war began in 2011, most of the syrian refugees have immigrated to turkey due to its open gate policy and the width of the border. by the end of 2015, it was estimated that there were 2.5 million syrian refugees in turkey. many of the syrian refugees live in sanliurfa due to its location on the border with syria. trichomonas vaginalis, apart from viral agents is the most common parasite among sexually transmitted infection agents. the aim of this study was to determine the ... | 2016 | 28124964 |
| molecular characterization of trichomonas vaginalis strains based on identifying their probable variations in asymptomatic patients. | the aim of this study was to identify the trichomonas vaginalis strains/haplotypes based on identifying their probable variations in asymptomatic patients referred to tabriz health centers, northwestern iran. | 2017 | 28127362 |
| prevalence of trichomoniasis among 18-48 year-old women in northwest of iran. | the aims of this study were to examine the prevalence of trichomoniasis among women aged 18 to 48 yr in ardabil, northwestern iran and the relationship between demographic factors and the risk of infection. | 2017 | 28127371 |
| costing of national sti program implementation for the global sti control strategy for the health sector, 2016-2021. | in 2016 the world health assembly adopted the global strategy on sexually transmitted infections (sti) 2016-2021 aiming to reduce curable stis by 90% by 2030. we costed scaling-up priority interventions to coverage targets. | 2017 | 28129372 |
| in vitro activity of nitazoxanide against some metronidazole-resistant and susceptible trichomonas vaginalis isolates. | trichomonas vaginalis cases refractory to metronidazole (mtz) treatment had been reported. this study aimed to the assessment of in vitro metronidazole resistance among trichomonas positive cases with treatment failure by determination of metronidazole minimal lethal concentration (mlc), and to the evaluation of the in vitro efficacy of nitazoxanide (ntz) as compared to metronidazole (mtz) in both resistant and susceptible isolates. drug testing was carried out by an aerobic tube assay where sus ... | 2017 | 28131737 |
| chlamydia trachomatis, neisseria gonorrhoeae, and trichomonas vaginalis screening and treatment of pregnant women in port-au-prince, haiti. | in haiti, routine screening for chlamydia trachomatis (ct), neisseria gonorrhoeae (ng), and trichomonas vaginalis (tv) among pregnant women is not conducted; yet these sexually transmitted infections (stis) are associated with adverse birth and newborn health outcomes. we aimed to assess the acceptability and feasibility of screening and the prevalence of stis among pregnant women in port-au-prince, haiti. pregnant women of at least 18 years of age who attend haitian study group for kaposi's sar ... | 2017 | 28134005 |
| natural products as new treatment options for trichomoniasis: a molecular docking investigation. | trichomoniasis, caused by the parasitic protozoan trichomonas vaginalis, is the most common non-viral sexually-transmitted disease, and there can be severe complications from trichomoniasis. antibiotic resistance in t. vaginalis is increasing, but there are currently no alternatives treatment options. there is a need to discover and develop new chemotherapeutic alternatives. plant-derived natural products have long served as sources for new medicinal agents, as well as new leads for drug discove ... | 2017 | 28134827 |
| impact of deploying multiple point-of-care tests with a 'sample first' approach on a sexual health clinical care pathway. a service evaluation. | to assess clinical service value of sti point-of-care test (poct) use in a 'sample first' clinical pathway (patients providing samples on arrival at clinic, before clinician consultation). specific outcomes were: patient acceptability; whether a rapid nucleic acid amplification test (naat) for chlamydia trachomatis/neisseria gonorrhoeae (ct/ng) could be used as a poct in practice; feasibility of non-naat poct implementation for trichomonas vaginalis (tv) and bacterial vaginosis (bv); impact on p ... | 2017 | 28159916 |
| partner notification and treatment for sexually transmitted infections among pregnant women in gaborone, botswana. | chlamydia trachomatis (ct), neisseria gonorrhoeae (ng), and trichomonas vaginalis (tv) are sexually transmitted infections (stis) associated with adverse birth outcomes. untreated partners contribute to high rates of sti reinfection; thus, partner notification and treatment remain important components of sti care and control. a prospective cohort study was conducted among 300 pregnant women presenting to the antenatal clinic at princess marina hospital in gaborone, botswana who enrolled in an st ... | 2017 | 28166698 |
| a review of expedited partner therapy for the management of sexually transmitted infections in adolescents. | adolescents are at high risk of acquiring and becoming reinfected with sexually transmitted infections. partner notification and treatment are essential to preventing the spread of sexually transmitted infections. expedited partner therapy (ept) is a method of partner treatment used by medical providers to treat patients' sexual partners without direct medical evaluation or counseling. the objective of this article is to review the current literature regarding ept effectiveness, patients' attitu ... | 2017 | 28167140 |
| medicinal plants and their isolated compounds showing anti-trichomonas vaginalis- activity. | trichomonas vaginalis is a major of non-viral sexually-transmitted infection and an important cause of serious obstetrical and gynecological complications. treatment options for trichomoniasis are limited to nitroimidazole compounds. the increasing resistance and allergic reactions to nitroimidazole and recurrent trichomoniasis make it essential to identify and develop new drugs against trichomoniasis. medicinal plants are an important source for discovery of new medications. this review discuss ... | 2017 | 28178618 |
| vaginal infections of albanian women infected with hpv and their impact in intraepithelial cervical lesions evidenced by pap test. | cervical cytology is the best single method for large screening of the population in identifying precancerous lesions of the uterine cervix. | 2017 | 28182076 |
| diagnosis of some genital-tract infections: part 1. an historical perspective. | making a prompt and accurate diagnosis of genital tract infections is the key to instituting appropriate treatment and the linchpin of sexually transmitted infection control. we present a brief history, not covering syphilis, of diagnostic events for each of six bacteria and one protozoan from the time of discovery up to the molecular revolution. the latter is touched upon but its impact will form the substance of a further presentation. here, hindsight is helpful in understanding the way in whi ... | 2017 | 28186463 |
| epitopes within recombinant α-actinin protein is serodiagnostic target for trichomonas vaginalis sexually transmitted infections. | to date there is no commercially-available serodiagnostic for women and men infected with trichomonas vaginalis. thirteen epitopes of the immunogenic t. vaginalis α-actinin (106.2-kda) are detected by sera of women patients, and 5 epitopes, a subset of the 13, are detected by sera of men. a truncated recombinant protein called act-p2 (63.5-kda) encoding the 5 epitopes is used for screening by elisa for antibody in sera of women and men. because act-p2 is poorly expressed in e. coli, we wanted al ... | 2017 | 28203642 |
| recombinant α-actinin subunit antigens of trichomonas vaginalis as potential vaccine candidates in protecting against trichomoniasis. | human trichomoniasis caused by trichomonas vaginalis is one of the most common sexually transmitted diseases with more than 200 million cases worldwide. it has caused a series of health problems to patients. for prevention and control of infectious diseases, vaccines are usually considered as one of the most cost-efficient tools. however, until now, work on the development of t. vaginalis vaccines is still mainly focused on the screening of potential immunogens. alpha-actinin characterized by hi ... | 2017 | 28209207 |
| syndromic diagnosis in evaluation of women with symptoms of vaginitis. | this review aims to determine the effectiveness of the use of syndrome diagnosis in the evaluation of vaginitis and to make suggestions based on the review findings. | 2017 | 28210940 |
| can trichomoniasis cause pharyngitis? a case report. | we report on a heterosexual male with sore throat diagnosed as oral trichomoniasis vaginalis. | 2016 | 28228954 |
| antiparasitic activity of 1,3-dioxolanes containing tellurium in trichomonas vaginalis. | the increased prevalence of metronidazole-resistant infections has resulted in a search for alternative drugs for the treatment of trichomoniasis. in the present study, we report the preparation and in vitro activity of three 1,3-dioxolanes that contain tellurium (ptedox 01, ptedox 02, and ptedox 03) against trichomonas vaginalis. six concentrations of these compounds were analyzed for in vitro activity against atcc 30236 isolate of t. vaginalis. ptedox 01 reported a cytotoxic effect against 100 ... | 2017 | 28236702 |
| simultaneous detection and identification of sti pathogens by multiplex real-time pcr in genital tract specimens in a selected area of apulia, a region of southern italy. | genital tract infections are globally a major cause of morbidity in sexually active individuals. the aim of this study was to investigate the prevalence and associations of co-infections of chlamydia trachomatis, neisseria gonorrhoeae, trichomonas vaginalis, mycoplasma hominis (mh), mycoplasma genitalium, ureaplasma urealyticum (uu) and ureaplasma parvum (up) in specimens collected from female (sf) and male (sm) patients. | 2017 | 28260146 |
| point-of-care sexually transmitted infection diagnostics: proceedings of the star sexually transmitted infection-clinical trial group programmatic meeting. | the goal of the point-of-care (poc) sexually transmitted infection (sti) diagnostics meeting was to review the state-of-the-art research and develop recommendations for the use of poc sti diagnostics. experts from academia, government, nonprofit, and industry discussed poc diagnostics for stis such as chlamydia trachomatis, human papillomavirus, neisseria gonorrhoeae, trichomonas vaginalis, and treponema pallidum. key objectives included a review of current and emerging technologies, clinical an ... | 2017 | 28282646 |
| survey of sexually transmitted disease laboratory methods in u.s. army laboratories, 2012. | sexually transmitted diseases (std) affect primarily young people (17-24 years). the u.s. military, with many young people, strives to maintain effective std treatment and prevention programs using current methods. laboratory testing technology and capacity are important for appropriate clinical management and to provide data to direct prevention programs. std laboratory capabilities are assessed in civilian and military laboratories using surveys. an army laboratory survey was conducted in 2007 ... | 2017 | 28290950 |
| potential of bisbenzimidazole-analogs toward metronidazole-resistant trichomonas vaginalis isolates. | a bisoxyphenylene-bisbenzimidazole series with increasing aliphatic chain length (ch2 to c10 h20 ) containing a meta (m) or para (p) benzimidazole linkage to the phenylene ring was tested for ability to inhibit the growth of metronidazole susceptible (c1) and refractory (085) trichomonas vaginalis isolates under aerobic and anaerobic conditions. compound 3m, 2,2'-[α,ω-propadiylbis(oxy-1,3-phenylene)]bis-1h-benzimidazole, displayed a 5.5-fold lower minimum inhibitory concentration (mic) towards t ... | 2017 | 28296056 |
| routine testing of mycoplasma genitalium and trichomonas vaginalis. | mycoplasma genitalium (mg) and trichomonas vaginalis (tv) are common sexual transmitted infections (sti). however, most sti screening programmes do not include routinely detection of these pathogens. consequently, epidemiological data about mg and tv in the general population is lacking. the current study aims to give insight into the prevalence of both infections, thereby guiding decisions whether testing for these pathogens should be included routinely. | 2017 | 28301989 |
| t. vaginalis exosome-like vesicles modify the cytokine profile and reduce inflammation in parasite-infected mice. | trichomonas vaginalis (tv) is a flagellated parasite commonly spread through sexual transmission. this protozoan initiates a severe inflammatory process, inducing nitric oxide, interleukin-6 (il-6), il-8, il-10, il-17, and il-22 production by host immune cells. the parasites elicit these responses by releasing surface lipophosphoglycan, small extracellular vesicles (exosomes) and other factors. tv exosomes are similar to mammalian exosomes and have been implicated in the modulation of il-8 secre ... | 2017 | 28345149 |
| epigenome mapping highlights chromatin-mediated gene regulation in the protozoan parasite trichomonas vaginalis. | trichomonas vaginalis is an extracellular flagellated protozoan parasite that causes trichomoniasis, one of the most common non-viral sexually transmitted diseases. to survive and to maintain infection, t. vaginalis adapts to a hostile host environment by regulating gene expression. however, the mechanisms of transcriptional regulation are poorly understood for this parasite. histone modification has a marked effect on chromatin structure and directs the recruitment of transcriptional machinery, ... | 2017 | 28345651 |
| the prevalence of trichomoniasis and associated factors among women treated at a university hospital in southern brazil. | trichomoniasis is the most prevalent non-viral sexually transmitted disease (std) in the world; however, it remains a neglected parasitic disease. this study aimed to determine the prevalence of trichomoniasis and its associated epidemiological factors among women treated at a hospital in southern brazil. | 2017 | 28346531 |
| urinary infection due to balantioides coli: a rare accidental zoonotic disease in an addicted and diabetic young female in iran. | balantiosis, a rare zoonotic infection resulting in dysentery, is caused by the large ciliated protozoan parasite balantioides coli. humans acquire this organism via the faecal-oral route. very rarely, extraintestinal infections can occur in the urinary tract system. there are very few case reports of urinary balantiosis in humans. | 2016 | 28348744 |
| high hiv prevalence and incidence among women in southern mozambique: evidence from the mdp microbicide feasibility study. | the study aimed to assess the feasibility of conducting large scale hiv prevention clinical trials in mozambique by measuring hiv prevalence and incidence among women of reproductive age. this paper describes the baseline socio-demographic characteristics of the mozambique microbicides development programme (mdp) feasibility cohort, baseline prevalence of hiv and other stis, and hiv incidence. | 2017 | 28350843 |
| trichomoniasis - are we giving the deserved attention to the most common non-viral sexually transmitted disease worldwide? | trichomonas vaginalis is the etiologic agent of trichomoniasis, the most common non-viral sexually transmitted disease (std) in the world. transmission: trichomoniasis is transmitted by sexual intercourse and transmission via fomites is rare. epidemiology, incidence and prevalence: the who estimates an incidence of 276 million new cases each year and prevalence of 187 million of infected individuals. however, the infection is not notifiable. pathology/symptomatology: the t. vaginalis infection r ... | 2016 | 28357378 |
| high prevalence of curable sexually transmitted infections among pregnant women in a rural county hospital in kilifi, kenya. | women attending antenatal care (anc) in resource-limited countries are frequently screened for syphilis and hiv, but rarely for other sexually transmitted infections (stis). we assessed the prevalence of curable stis, defined as infection with either chlamydia trachomatis or neisseria gonorrhoeae or trichomonas vaginalis, from july to september 2015. | 2017 | 28362869 |
| trichomonas vaginalis infection in symbiosis with trichomonasvirus and mycoplasma. | trichomonas vaginalis is a protozoan with an extracellular obligatory parasitic lifestyle exclusively adapted to the human urogenital tract and responsible for nearly a quarter billion sexually transmitted infections worldwide each year. this review focuses on symbiotic trichomonasvirus and mycoplasma carried by the protozoan, their molecular features and their role in altering the human vaginal microbiome and the immunopathogenicity of the parasite. improved diagnostics and larger clinical inte ... | 2017 | 28366838 |
| transcriptomics indicates active and passive metronidazole resistance mechanisms in three seminal giardia lines. | giardia duodenalis is an intestinal parasite that causes 200-300 million episodes of diarrhoea annually. metronidazole (mtz) is a front-line anti-giardial, but treatment failure is common and clinical resistance has been demonstrated. mtz is thought to be activated within the parasite by oxidoreductase enzymes, and to kill by causing oxidative damage. in g. duodenalis, mtz resistance involves active and passive mechanisms. relatively low activity of iron-sulfur binding proteins, namely pyruvate: ... | 2017 | 28367140 |
| prevalence of trichomonas vaginalis in women of reproductive age at a family health clinic. | trichomonas vaginalis is considered the most prevalent curable sexually transmitted infection, and its occurrence exceeds that of gonococcal and chlamydia infections. this parasite has been identified as responsible for the increased risk of transmission of hiv and has also been associated with prostate and cervical cancer. many carriers of t. vaginalis are asymptomatic and, when experiencing a health problem, they most often have nonspecific symptoms. the aim of this research was to estimate th ... | 2017 | 28368862 |
| the costa of trichomonads: a complex macromolecular cytoskeleton structure made of uncommon proteins. | the costa is a prominent striated fiber that is found in protozoa of the trichomonadidae family that present an undulating membrane. it is composed primarily of proteins that have not yet been explored. in this study, we used cell fractionation to obtain a highly enriched costa fraction whose structure and composition was further analyzed by electron microscopy and mass spectrometry. | 2017 | 28369980 |
| a cross-sectional analysis of trichomonas vaginalis infection among heterosexual hiv-1 serodiscordant african couples. | trichomonas vaginalis is the most prevalent curable sti worldwide and has been associated with adverse health outcomes and increased hiv-1 transmission risk. we conducted a cross-sectional analysis among couples to assess how characteristics of both individuals in sexual partnerships are associated with the prevalence of male and female t. vaginalis infection. | 2017 | 28377421 |
| the anti-trichomonas vaginalis phloroglucinol derivative isoaustrobrasilol b modulates extracellular nucleotides hydrolysis. | trichomonas vaginalis causes trichomoniasis, a neglected sexually transmitted disease. due to severe health consequences and treatment failure, new therapeutic alternatives are crucial. phloroglucinols from southern brazilian hypericum species demonstrated anti-t. vaginalis and anti-leishmania amazonensis activities. the modulation of biochemical pathways involved in the control of inflammatory response by ectonucleotidases, ntpdase and ecto-5'-nucleotidase, represents new targets for combating ... | 2017 | 28390095 |
| dorsal longitudinal foreskin cut is associated with reduced risk of hiv, syphilis and genital herpes in men: a cross-sectional study in papua new guinea. | various forms of penile foreskin cutting are practised in papua new guinea. in the context of an ecological association observed between hiv infection and the dorsal longitudinal foreskin cut, we undertook an investigation of this relationship at the individual level. | 2017 | 28406272 |
| expression of the enzymatically active legumain-like cysteine proteinase tvlegu-1 of trichomonas vaginalis in pichia pastoris. | the legumain-like cysteine proteinase tvlegu-1 from trichomonas vaginalis plays a major role in trichomonal cytoadherence. however, its structure-function characterization has been limited by the lack of a reliable recombinant expression platform to produce this protein in its native folded conformation. tvlegu-1 has been expressed in escherichia coli as inclusion bodies and all efforts to refold it have failed. here, we describe the expression of the synthetic codon-optimized tvlegu-1 (tvlegu-1 ... | 2017 | 28419821 |
| immunocytochemistry improving the diagnosis of trichomonas vaginalis infections. | the aim of this study was to evaluate the immunocytochemistry (icc) to diagnose trichomoniasis, particularly asymptomatic infections. by culture serial dilutions, icc was able to detect 1 trophozoite/ml, while the culture was positive up to 100 trophozoites/ml. the icc in vivo detection capability was assessed in vaginal secretions of mice experimentally infected and in vaginal swabs from asymptomatic hiv-positive pregnant women compared with culture. all vaginal secretion samples from mice were ... | 2017 | 28424786 |
| profile of the triplex assay for detection of chlamydia, gonorrhea and trichomonas using the bd max™ system. | chlamydia, gonorrhea and trichomonas are the most common curable sti. improved access to testing could reduce infection rates and prevent sequelae. nucleic acid amplification tests are the recommend class of diagnostic assay for these infections which are often asymptomatic. areas covered: a description of the bd max™ system (max) and the bd max ct/gc/tv assay is provided along with data from a large us clinical trial. the capacity of the system for other tests and for lab developed assays is al ... | 2017 | 28425774 |
| cervicovaginal levels of human β-defensin 1, 2, 3, and 4 of reproductive-aged women with chlamydia trachomatis infection. | this study included women attending primary health care units in botucatu, são paulo, brazil, to assess the cervicovaginal levels of human β-defensin (hbd) 1, 2, 3, and 4 during chlamydia trachomatis infection. | 2017 | 28430679 |
| proton pump inhibitors are associated with a reduced likelihood for sexually transmitted diseases in women in the emergency department. | proton pump inhibitors (ppis) have been shown in cell culture to kill trichomonas vaginalis (tv) at lower half maximal inhibitory concentration values than metronidazole (flagyl), the most common medication used to treat the infection. however, there have been no previous clinical investigations to determine if ppis are associated with reduced risk for tv. | 2017 | 28442805 |
| prevalence of human papillomavirus, chlamydia trachomatis, and trichomonas vaginalis infections in amazonian women with normal and abnormal cytology. | sexually transmitted infections are an important cause of morbidity among sexually active women worldwide, and have been implicated as cofactors in the pathogenesis of cervical cancer. we investigated the prevalence of human papillomavirus (hpv), chlamydia trachomatis (ct), and trichomonas vaginalis (tv), and accessed the diversity of hpv in women with normal and abnormal cytology in manaus, brazil. we used polymerase chain reaction and hpv genotyping by direct sequencing. the chi-square test wa ... | 2017 | 28453175 |
| women with symptoms of a urinary tract infection but a negative urine culture: pcr-based quantification of escherichia coli suggests infection in most cases. | our objective was to examine whether or not women with symptoms of a urinary tract infection but with a negative culture (20%-30%) do have an infection. | 2017 | 28457846 |
| glycogen synthase from the parabasalian parasite trichomonas vaginalis: an unusual member of the starch/glycogen synthase family. | trichomonas vaginalis, a parasitic protist, is the causative agent of the common sexually-transmitted infection trichomoniasis. the organism has long been known to synthesize substantial glycogen as a storage polysaccharide, presumably mobilizing this compound during periods of carbohydrate limitation, such as might be encountered during transmission between hosts. however, little is known regarding the enzymes of glycogen metabolism in t. vaginalis. we had previously described the identificatio ... | 2017 | 28465215 |
| evaluating the utility of syndromic case management for three sexually transmitted infections in women visiting hospitals in delhi, india. | utility of syndromic case management (scm) in women visiting obstetrics & gynecology department needs to be evaluated as it is subjective and imperfect. consequently, antibiotic resistance has accelerated along with increased risk of infection to the partners. to understand the effectiveness and/or inadequacies of scm, 11000 women were recruited and examined by clinicians for infection by chlamydia trachomatis (ct), neisseria gonorrhoeae (ng), trichomonas vaginalis (tv), bacterial vaginosis (bv) ... | 2017 | 28469158 |
| prevalence and risk factors associated with stis among women initiating contraceptive implants in kingston, jamaica. | there is limited information on rates of stis in jamaica due to syndromic management and limited aetiological surveillance. we examined the prevalence of chlamydia trachomatis (ct), neisseria gonorrhoeae (ng) and trichomonas vaginalis (tv) and characteristics associated with stis among sexually active women who participated in a randomised trial of a progestin implant initiation in jamaica (the sino-implant study (sis)). | 2017 | 28476913 |
| double-stranded rna viral infection of trichomonas vaginalis (tvv1) in iranian isolates. | the totiviridae family includes a number of viruses that can infect protozoan parasites such as leishmania and giardia and fungi like saccharomyces cerevisiae. some isolates of trichomonas vaginalis are also infected with one or more double-stranded rna (dsrna) viruses. in this study, the frequency of trichomonas vaginalis virus (tvv1) was evaluated in iranian isolates of t. vaginalis in tehran, iran. one thousand five hundred vaginal samples were collected from patients attending obstetrics and ... | 2017 | 28478201 |
| aerobic vaginitis: no longer a stranger. | aerobic vaginitis (av) is the name given in 2002 to a vaginal infectious entity which was not recognized as such before. it is characterized by abnormal (dysbiotic) vaginal microflora containing aerobic, enteric bacteria, variable levels of vaginal inflammation and deficient epithelial maturation. although av and bacterial vaginosis (bv) share some characteristics, such as a diminished number or absence of lactobacilli, increased discharge (fishy smelling in bv, while in severe forms of av, a fo ... | 2017 | 28502874 |
| differential protein expressions in virus-infected and uninfected trichomonas vaginalis. | protozoan viruses may influence the function and pathogenicity of the protozoa. trichomonas vaginalis is a parasitic protozoan that could contain a double stranded rna (dsrna) virus, t. vaginalis virus (tvv). however, there are few reports on the properties of the virus. to further determine variations in protein expression of t. vaginalis, we detected 2 strains of t. vaginalis; the virus-infected (v(+)) and uninfected (v(-)) isolates to examine differentially expressed proteins upon tvv infecti ... | 2017 | 28506033 |
| interaction between trichomonas vaginalis and the prostate epithelium. | most men infected with trichomonas vaginalis are asymptomatic and can remain undiagnosed and untreated. this has been hypothesized to result in chronic persistent prostatic infection. adhesion of the protozoan organisms to mucosal cells is considered a first and prerequisite step for t. vaginalis infection. adhesion of t. vaginalis to prostate epithelial cells has not yet been observed; however, there are several reports about inflammation of prostate epithelial cells induced by t. vaginalis. th ... | 2017 | 28506046 |
| a community based study on pelvic inflammatory disease in postmenopausal females: microbiological spectrum and socio-demographic correlates. | pelvic inflammatory disease (pid) is a common and serious complication of sexually transmitted diseases in young women but is rarely diagnosed in the postmenopausal women. very few studies have been done regarding post-menopausal pid. | 2017 | 28511414 |
| [common genital infections]. | vulvo-vaginal infections are frequently encountered by gynecologists and general practitioners. the diagnosis and the recurrence of these affections must lead to a discussion about sexually transmitted disease, notably when trichomonas vaginalis and herpetic infections are found. even if they do not correspond to classical sexually transmitted diseases, their prevalence is increased by sexual intercourses reports and the number of partners which should also be treated. it is necessary to documen ... | 2016 | 28525226 |
| epidemiological investigation of the relationship between common lower genital tract infections and high-risk human papillomavirus infections among women in beijing, china. | the incidence of lower genital tract infections in china has been increasing in recent years. the link between high-risk human papillomavirus (hr-hpv) and other sexually transmitted diseases (stds) remains unclear. | 2017 | 28531212 |
| strategies for prevention and treatment of trichomonas vaginalis infections. | the last estimated annual incidence of trichomonas vaginalis worldwide exceeds that of chlamydia and gonorrhea combined. this critical review updates the state of the art on advances in t. vaginalis diagnostics and strategies for treatment and prevention of trichomoniasis. in particular, new data on treatment outcomes for topical administration of formulations are reviewed and discussed. | 2017 | 28539504 |
| prevalence and risk factors associated with sexually transmitted infections (stis) among women of reproductive age in swaziland. | sexually transmitted infections (stis) remain an important public health problem with approximately half a billion new cases annually among persons aged 15-49 years. epidemiological data on stis among women of reproductive age in swaziland are limited. the availability of epidemiological data on stis and associated risk factors in this population is essential for the development of successful prevention, diagnosis and management strategies in the country. the study aimed to determine the prevale ... | 2017 | 28559923 |
| c-reactive protein is differentially modulated by co-existing infections, vitamin deficiencies and maternal factors in pregnant and lactating indigenous panamanian women. | the usefulness of c-reactive protein (crp) as a non-specific marker of inflammation during pregnancy and lactation is unclear in impoverished populations where co-existing infections and vitamin deficiencies are common. | 2017 | 28571565 |
| potential of synthetic endoperoxides against trichomonas vaginalis in vitro. | metronidazole is well known for medicine against trichomonas vaginalis infection, but it has side effects though it is effective, and especially because reports of metronidazole-tolerant species are increasing, the development of new medicine is being required. here, we noticed the killing effects of endoperoxide compounds, n-89 and n-251 as new antimalarial drug candidates, on t. vaginalis and searched the possibility of development of new medicine. we added each of metronidazole, artemisinin, ... | 2017 | 28571765 |
| synthesis, antiprotozoal activity, and chemoinformatic analysis of 2-(methylthio)-1h-benzimidazole-5-carboxamide derivatives: identification of new selective giardicidal and trichomonicidal compounds. | a series of twelve new 2-(methylthio)-1h-benzimidazole-5-carboxamide derivatives (1-12) were synthesized and their antiparasitic activity was tested in vitro against giardia intestinalis, trichomonas vaginalis and entamoeba histolytica. experimental evaluations showed ic50 values within the nanomolar range for all tested compounds, some showing higher activity than metronidazole and albendazole. a chemoinformatic study was used to compare the structure-activity relationship of the synthesized ca ... | 2017 | 28595066 |
| burden and characteristics of hiv infection among female sex workers in kampala, uganda - a respondent-driven sampling survey. | sex workers in uganda are at significant risk for hiv infection. we characterized the hiv epidemic among kampala female sex workers (fsw). | 2017 | 28601086 |
| the fluorescent protein ilov outperforms egfp as a reporter gene in the microaerophilic protozoan trichomonas vaginalis. | trichomonas vaginalis is a flagellated protozoan causing a notorious urogenital infection in humans. due to its anaerobic metabolism, an alternative fluorescent protein that can be readily expressed in oxygen-deprived conditions is ideal. this study assessed the performance of ilov, which does not require oxygen to function, as compared to the conventional enhanced green fluorescent protein (egfp) in t. vaginalis. the results indicated that ilov outperforms egfp in both transient and stable expr ... | 2017 | 28602728 |