Publications
| Title | Abstract | Year Filter | PMID(sorted ascending) Filter |
|---|
| effect of statin use on influenza vaccine effectiveness. | recent studies suggest that statin use may reduce influenza vaccine effectiveness (ve), but laboratory-confirmed influenza was not assessed. | 2016 | 27471318 |
| prediction of influenza b vaccine effectiveness from sequence data. | influenza is a contagious respiratory illness that causes significant human morbidity and mortality, affecting 5-15% of the population in a typical epidemic season. human influenza epidemics are caused by types a and b, with roughly 25% of human cases due to influenza b. influenza b is a single-stranded rna virus with a high mutation rate, and both prior immune history and vaccination put significant pressure on the virus to evolve. due to the high rate of viral evolution, the influenza b vaccin ... | 2016 | 27473305 |
| duration of fever and other symptoms after the inhalation of laninamivir octanoate hydrate for influenza treatment; comparison among the four japanese influenza seasons from 2011-2012 to 2014-2015. | the duration of fever and other symptoms as markers of the clinical effectiveness of laninamivir octanoate hydrate (laninamivir) were investigated in the japanese 2014-2015 influenza season and the results were compared with those of the previous three seasons, 2011-2012 to 2013-2014. from these four seasons, the data of 636 influenza a(h3n2) and 128 influenza b patients was available for analysis. no significant difference was found in their baseline characteristics. the median duration of feve ... | 2016 | 27493024 |
| [prevalence characteristics of influenza viruses in children in beijing during 2014-2015 and 2015-2016 influenza seasons]. | to compare the prevalence characteristics of influenza viruses in children in beijing during 2014-2015 and 2015-2016 influenza seasons. | 2016 | 27510869 |
| dynamic patterns of circulating influenza virus from 2005 to 2012 in shandong province, china. | to identify circulating emerging/reemerging viral strains and epidemiological trends, an influenza sentinel surveillance network was established in shandong province, china, in 2005. nasal and/or throat swabs from patients with influenza-like-illness were collected at sentinel hospitals. influenza viruses were detected by reverse transcription polymerase chain reaction (rt-pcr) or virus isolation. from october 2005 to march 2012, 7763 (21.44 %) of 36,209 swab samples were positive for influenza ... | 2016 | 27515172 |
| influenza b/streptococcal co-infection complicated by organizing pneumonia. | organizing pneumonia is a rare complication of influenza infection that has substantial morbidity. we report the first case of organizing pneumonia associated with influenza b and streptococcus pneumoniae coinfection that had significant improvement with corticosteroid treatment. the clinical and radiological features of organizing pneumonia associated with this coinfection are similar to those after influenza a infection. timely use of systemic glucocorticosteroids would be of benefit in promot ... | 2016 | 27516886 |
| serum amyloid a (saa) is an early biomarker of influenza virus disease in balb/c, c57bl/2, swiss-webster, and dba.2 mice. | assessment of influenza virus disease progression and efficacy of antiviral therapy in the widely used mouse models relies mostly on body weight loss and lung virus titers as markers of disease. however, both parameters have their shortcomings. therefore, the aim of our study was to find non-invasive markers in the murine model of severe influenza that could detect disease early and predict disease outcome. balb/c mice were lethally infected with influenza a(h1n1)pdm09 virus and serum samples we ... | 2016 | 27523492 |
| [influenza surveillance in five consecutive seasons during post pandemic period: results from national influenza center, turkey]. | influenza surveillance provides data about the characteristics of influenza activity, types, sub-types and antigenic properties of the influenza viruses in circulation in a region. surveillance also provides for the preparation against potential influenza pandemics with the identification of the genetic properties of viruses and the mutant strains that could pose a threat. in this study, data in the scope of national influenza surveillance carried out by national influenza center, turkey for fiv ... | 2016 | 27525396 |
| [evaluation of sentinel influenza surveillance of the last two seasons: 2013-2014 and 2014-2015]. | flu caused by influenza viruses, is a serious public health problem all over the world with its high morbidity and mortality. therefore world health organization (who) regularly collects the results of national influenza surveillance, evaluates the results and shares them on international portal. thus, it provides the possibility of rapid prevention and preparation of countries that needs to be taken on the fight against the epidemic flu. starting from 2004-2005 season until today the current fl ... | 2016 | 27525397 |
| [mutations in the neuraminidase gene of the epidemic influenza virus strain isolated in the 2012-2013 season and improvement of a pcr assay for the detection of influenza virus]. | in 2011, we developed a real-time rt-pcr method to rapidly and sensitively detect three subtypes of influenza a virus [h1n1, h3n2, and influenza (h1n1) 2009] and influenza b virus (the conventional pcr method). this method was useful during the 2011-2012 epidemic season. however, epidemic influenza a virus strain h3n2 in the 2012-2013 season was undetectable by this method, possibly due to mutation in the neuraminidase (na) gene of epidemic influenza a virus strain h3n2. therefore, we improved t ... | 2014 | 27526538 |
| epidemiological and virological characterization of influenza b virus infections. | while influenza a viruses comprise a heterogeneous group of clinically relevant influenza viruses, influenza b viruses form a more homogeneous cluster, divided mainly into two lineages: victoria and yamagata. this divergence has complicated seasonal influenza vaccine design, which traditionally contained two seasonal influenza a virus strains and one influenza b virus strain. we examined the distribution of the two influenza b virus lineages in israel, between 2011-2014, in hospitalized and in n ... | 2016 | 27533045 |
| hospitalization for influenza a versus b. | the extent to which influenza a and b infection differs remains uncertain. | 2016 | 27535144 |
| [benign acute childhood myositis: clinical series and literature review]. | benign acute childhood myositis (bacm) is a rare clinical condition that mainly affects pre-school and school age-children. it is usually preceded by a viral illness, particularly influenza virus infection. | 2016 | 27542581 |
| a second rna-binding site in the ns1 protein of influenza b virus. | influenza viruses cause a highly contagious respiratory disease in humans. the ns1 proteins of influenza a and b viruses (ns1a and ns1b proteins, respectively) are composed of two domains, a dimeric n-terminal domain and a c-terminal domain, connected by a flexible polypeptide linker. here we report the 2.0-å x-ray crystal structure and nuclear magnetic resonance studies of the ns1b c-terminal domain, which reveal a novel and unexpected basic rna-binding site that is not present in the ns1a prot ... | 2016 | 27545620 |
| in vitro evaluation of the antiviral activity of methylglyoxal against influenza b virus infection. | influenza a and b virus infections are serious public health concerns globally. however, the concerns regarding influenza b infection have been underestimated. the currently used anti-influenza drugs have not provided equal efficacy for both influenza a and b viruses. susceptibility to neuraminidase (na) inhibitors has been observed to be lower for influenza b viruses than for influenza a viruses. moreover, the emergence of resistance to anti-influenza drugs underscores the need to develop new d ... | 2017 | 27558282 |
| prevention and control of seasonal influenza with vaccines. | this report updates the 2015-16 recommendations of the advisory committee on immunization practices (acip) regarding the use of seasonal influenza vaccines (grohskopf la, sokolow lz, olsen sj, bresee js, broder kr, karron ra. prevention and control of influenza with vaccines: recommendations of the advisory committee on immunization practices, united states, 2015-16 influenza season. mmwr morb mortal wkly rep 2015;64:818-25). routine annual influenza vaccination is recommended for all persons ag ... | 2016 | 27560619 |
| antiviral activity of kr-23502 targeting nuclear export of influenza b virus ribonucleoproteins. | the spiro compound 5,6-dimethyl-3h,3'h-spiro(benzofuran-2,1'-isobenzofuran)-3,3'-dione (kr-23502) has antiviral activity against influenza a and more potently b viruses. the aim of this study is to elucidate its mechanism of action. subcellular localization and time-course expression of influenza b viral proteins, nucleoprotein (np) and matrix protein 1 (m1), showed that kr-23502 reduced their amounts within 5 h post-infection. early steps of virus life cycle, including virus entry, nuclear loca ... | 2016 | 27565992 |
| influenza b virus m2 protein can functionally replace its influenza a virus counterpart in promoting virus replication. | the m2 protein (am2 and bm2) of influenza a and b viruses function as a proton channel essential for viral replication. they also carry a cytoplasmic tail whose functions are not fully delineated. it is currently unknown whether these proteins could be replaced functionally in a viral context. here, we generated single-cycle influenza a viruses (sciav-δha) carrying various m2-2a-mcherry constructs in the segment 4 (ha) and evaluated their growth in complementing cells. intriguingly, the sciav-δh ... | 2016 | 27567258 |
| phenotypic and genotypic analysis of influenza viruses isolated from adult subjects during a phase ii study of intravenous zanamivir in hospitalised subjects. | intravenous zanamivir (ivz) is a neuraminidase (na) inhibitor (nai) under investigation for the treatment of subjects hospitalised with influenza. the study included 130 symptomatic, hospitalised adults with influenza. subjects received ivz for 5-10 days. viruses were cultured and analysed for susceptibility to zanamivir. mean ic50s (n = 50) (±sd) for influenza a/h1n1pdm09, a/h3n2 and influenza b were 0.20 ± 0.06, 0.26 ± 0.07 and 1.61 ± 0.35 nm, respectively, and are comparable to data observed ... | 2016 | 27568923 |
| direct comparison of alere i and cobas liat influenza a and b tests for rapid detection of influenza virus infection. | we compared two rapid, point-of care nucleic acid amplification tests for detection of influenza a and b viruses (alere i [alere] and cobas liat [roche diagnostics]) with the influenza a and b virus test components of the filmarray respiratory panel (biofire diagnostics) using 129 respiratory specimens collected in universal viral transport medium (80 influenza a virus and 16 influenza b virus positive) from both adult and pediatric patients. the sensitivities of the alere test were 71.3% for in ... | 2016 | 27582513 |
| identification of pyrrolo[3,2-c]pyridin-4-amine compounds as a new class of entry inhibitors against influenza viruses in vitro. | various influenza virus entry inhibitors are being developed as therapeutic antiviral agents in ongoing preparation for emerging influenza viruses, particularly those that may possess drug resistance to the current fda-approved neuraminidase inhibitors. in this study, small molecules having the pyrrolopyridinamine (ppa), aminothiadiazole (atd), dihydrofuropyridine carboxamide (hpc), or imidazopyridinamine (ipa) moiety were selected from a target-focused chemical library for their inhibitory acti ... | 2016 | 27586275 |
| influenza b virus non-structural protein 1 counteracts isg15 antiviral activity by sequestering isgylated viral proteins. | the ubiquitin-like protein isg15 and its conjugation to proteins (isgylation) are strongly induced by type i interferon. influenza b virus encodes non-structural protein 1 (ns1b) that binds human isg15 and provides an appropriate model for determining how isgylation affects virus replication in human cells. here using a recombinant virus encoding a ns1b protein defective in isg15 binding, we show that ns1b counteracts isgylation-mediated antiviral activity by binding and sequestering isgylated v ... | 2016 | 27587337 |
| titration of individual strains in trivalent live-attenuated influenza vaccine without neutralization. | formulation and quality control of trivalent live-attenuated influenza vaccine requires titration of infectivity of individual strains in the trivalent mix. this is usually performed by selective neutralization of two of the three strains and titration of the un-neutralized strain in cell culture or embryonated eggs. this procedure requires standard sera with high neutralizing titer against each of the three strains. obtaining standard sera, which can specifically neutralize only the correspondi ... | 2016 | 27596269 |
| recommendations for prevention and control of influenza in children, 2016-2017. | the purpose of this statement is to update recommendations for the routine use of seasonal influenza vaccine and antiviral medications for the prevention and treatment of influenza in children. the aap recommends annual seasonal influenza immunization for everyone 6 months and older, including children and adolescents. highlights for the upcoming 2016-2017 season include the following: 1. annual universal influenza immunization is indicated with either a trivalent or quadrivalent (no preference) ... | 2016 | 27600320 |
| influenza b virus outbreak at a religious residential school for boys in northern bangladesh, 2011. | national media reported a febrile illness among dormitory residents of a boys' religious school. we investigated the outbreak to identify cause. | 2017 | 27603154 |
| thyroid storm presenting as psychosis: masked by diabetic ketoacidosis. | while extremely uncommon, diabetic ketoacidosis (dka) and thyroid storm (ts) are endocrine emergencies that can coexist. we describe a case with a confounding clinical presentation that identifies these two emergencies within the setting of sepsis and influenza. | 2016 | 27609719 |
| analytical performance of the bd veritor™ system for rapid detection of influenza virus a and b in a primary healthcare setting. | infections with influenza a virus cannot be clinically differentiated from infections caused by influenza b virus or other respiratory viruses. additionally, although antiviral treatment is available for influenza a virus, it is not effective for the other viruses and must be initiated early in the course of disease for it to be effective. for these reasons, there is a need for a rapid, accurate diagnostic test for use in physicians' offices at the time patients are seen. we report the first fie ... | 2016 | 27612949 |
| epidemiology of influenza b in australia: 2001-2014 influenza seasons. | influenza b is characterised by two antigenic lineages: b/victoria and b/yamagata. these lineages circulate together with influenza a during influenza seasons, with varying incidence from year to year and by geographic region. | 2017 | 27650482 |
| etiology of influenza-like illnesses from sentinel network practitioners in réunion island, 2011-2012. | in réunion island, despite an influenza surveillance established since 1996 by the sentinel general practitioner's network, little is known about the etiology of influenza like-illness (ili) that differs from influenza viruses in a tropical area. we set up a retrospective study using nasal swabs collected by sentinel gps from ili patients in 2011 and 2012. a total of 250 swabs were randomly selected and analyzed by multiplex reverse transcriptase polymerase chain reaction (rt-pcr) including rese ... | 2016 | 27654509 |
| disruption of src homology 3-binding motif within non-structural protein 1 of influenza b virus unexpectedly enhances viral replication in human cells. | the influenza virus non-structural protein 1 (ns1) is a multifunctional virulence factor that plays a crucial role during infection by blocking the innate antiviral immune response of infected cells. in contrast to the well-studied ns1 protein of influenza a virus, knowledge about structure and functions of the influenza b virus homologue b/ns1, which shares less than 25 % sequence identity, is still limited. here, we report on a reverse genetic analysis to study the role of a highly conserved c ... | 2016 | 27654951 |
| update: influenza activity - united states and worldwide, may 22-september 10, 2016. | during may 22-september 10, 2016,* the united states experienced typical low levels of seasonal influenza activity overall; beginning in late august, clinical laboratories reported a slight increase in influenza positive test results and cdc received reports of a small number of localized influenza outbreaks caused by influenza a (h3n2) viruses. influenza a (h1n1)pdm09, influenza a (h3n2), and influenza b viruses were detected during may-september in the united states and worldwide. the majority ... | 2016 | 27657671 |
| sensitive detection and simultaneous discrimination of influenza a and b viruses in nasopharyngeal swabs in a single assay using next-generation sequencing-based diagnostics. | reassortment of 2009 (h1n1) pandemic influenza virus (pdh1n1) with other strains may produce more virulent and pathogenic forms, detection and their rapid characterization is critical. in this study, we reported a "one-size-fits-all" approach using a next-generation sequencing (ngs) detection platform to extensively identify influenza viral genomes for diagnosis and determination of novel virulence and drug resistance markers. a de novo module and other bioinformatics tools were used to generate ... | 2017 | 27658193 |
| spirometry filters can be used to detect exhaled respiratory viruses. | respiratory viruses are very common in the community and contribute to the burden of illness for patients with chronic respiratory diseases, including acute exacerbations. traditional sampling methods are invasive and problematic to repeat. accordingly, we explored whether respiratory viruses could be isolated from disposable spirometry filters and whether detection of viruses in this context represented presence in the upper or lower respiratory tract. discovery (n = 53) and validation (n = ... | 2016 | 27669334 |
| evaluation of self-swabbing coupled with a telephone health helpline as an adjunct tool for surveillance of influenza viruses in ontario. | calls to a telephone health helpline (thhl) have been previously evaluated for the ability to monitor specific syndromes, such as fever and influenza-like-illness or gastrointestinal illness. this method of surveillance has been shown to be highly correlated with traditional surveillance methods, and to have potential for early detection of community-based illness. self-sampling, or having a person take his/her own nasal swab, has also proven successful as a useful method for obtaining a specime ... | 2016 | 27677310 |
| effectiveness of seasonal influenza vaccine for adults and children in preventing laboratory-confirmed influenza in primary care in the united kingdom: 2015/16 end-of-season results. | the united kingdom (uk) is in the third season of introducing universal paediatric influenza vaccination with a quadrivalent live attenuated influenza vaccine (laiv). the 2015/16 season in the uk was initially dominated by influenza a(h1n1)pdm09 and then influenza of b/victoria lineage, not contained in that season's adult trivalent inactivated influenza vaccine (iiv). overall adjusted end-of-season vaccine effectiveness (ve) was 52.4% (95% confidence interval (ci): 41.0-61.6) against influenza- ... | 2016 | 27684603 |
| immunogenicity of as03-adjuvanted and non-adjuvanted trivalent inactivated influenza vaccines in elderly adults: a phase 3, randomized trial and post-hoc correlate of protection analysis. | in this study we describe the immunogenicity results from a subset of older people (n = 5187) who participated in a phase 3 randomized, observer-blinded trial of as03-tiv versus tiv (fluarix™) (clinicaltrials.gov, nct00753272). participants received one dose of as03-tiv or tiv in each study year and antibody titers against the vaccine strains were assessed using hemagglutination-inhibition (hi) assay at 21 d and 180 d post-vaccination in each vaccine group in the 2008/09 (year 1) and 2009/10 (ye ... | 2016 | 27690762 |
| 2014-2015 influenza vaccine effectiveness in the united states by vaccine type. | circulating a/h3n2 influenza viruses drifted significantly after strain selection for the 2014-2015 vaccines. also in 2014-2015, the advisory committee on immunization practices recommended preferential use of live attenuated influenza vaccine (laiv) over inactivated influenza vaccine (iiv) among children aged 2-8 years. | 2016 | 27702768 |
| invasive aspergillosis associated with severe influenza infections. | background. invasive aspergillosis may occur in the setting of severe influenza infections due to viral-induced respiratory epithelium disruption and impaired immune effects, but data are limited. methods. a retrospective study was conducted among severe influenza cases requiring medical intensive care unit (icu) admission at an academic center during the 2015-2016 season. data collected included respiratory cultures, medical conditions and immunosuppressants, laboratory and radiographic data, ... | 2016 | 27704024 |
| detection of influenza b viruses with reduced sensitivity to neuraminidase inhibitor in morocco during 2014/15 season. | we monitored phenotypic and genotypic susceptibility of influenza viruses circulating in morocco during 2014-2015 to oseltamivir and zanamivir. throat and nasal swab specimens were collected from outpatients (with influenza-like illness) and inpatients (with severe acute respiratory illness) and tested for influenza viruses using real-time reverse transcription polymerase chain reaction. positive samples were inoculated in mdck cells and virus phenotypic susceptibility to neuraminidase inhibitor ... | 2016 | 27714739 |
| evaluation of the rapid influenza detection tests gold sign flu and quick navi-flu for the detection of influenza a and b virus antigens in adults during the influenza season. | as the characteristics and accuracy of rapid influenza detection tests (ridts) vary, the development of a high-performance ridt has been eagerly anticipated. in this study, the new ridt gold sign flu and the existing ridt quick navi-flu were evaluated in terms of detecting the antigens of influenza viruses a and b in japanese adults with influenza-like symptoms. the study was performed from december 2013 to march 2014. among the 123 patients from whom nasopharyngeal swab specimens were collected ... | 2016 | 27720945 |
| economic outcomes of influenza in hospitalized elderly with and without icu admission. | to describe direct medical costs of influenza in hospitalized elderly, with and without intensive care unit (icu) admission, during the 2014-2015 season in hong kong. | 2017 | 27740538 |
| acute liver failure: outcome and value of pediatric end-stage liver disease score in pediatric cases. | the aims of this study were to analyze the characteristics of patients with acute liver failure (alf) in our center and evaluate the prognostic value of the pediatric end-stage liver disease (peld) score calculated at admission. | 2016 | 27749626 |
| estimation of influenza-attributable medically attended acute respiratory illness by influenza type/subtype and age, germany, 2001/02-2014/15. | the total burden of influenza in primary care is difficult to assess. the case definition of medically attended "acute respiratory infection" (maari) in the german physician sentinel is sensitive; however, it requires modelling techniques to derive estimates of disease attributable to influenza. we aimed to examine the impact of type/subtype and age. | 2017 | 27754611 |
| epidemiology and surveillance of influenza viruses in uganda between 2008 and 2014. | influenza surveillance was conducted in uganda from october 2008 to december 2014 to identify and understand the epidemiology of circulating influenza strains in out-patient clinic attendees with influenza-like illness and inform control strategies. | 2016 | 27755572 |
| geolocalization of influenza outbreak within an acute care population: a layered-surveillance approach. | we seek to use a novel layered-surveillance approach to localize influenza clusters within an acute care population. the first layer of this system is a syndromic surveillance screen to guide rapid polymerase chain reaction testing. the second layer is geolocalization and cluster analysis of these patients. we posit that any identified clusters could represent at-risk populations who could serve as high-yield targets for preventive medical interventions. | 2016 | 27772674 |
| trivalent inactivated influenza vaccine effective against influenza a(h3n2) variant viruses in children during the 2014/15 season, japan. | the 2014/15 influenza season in japan was characterised by predominant influenza a(h3n2) activity; 99% of influenza a viruses detected were a(h3n2). subclade 3c.2a viruses were the major epidemic a(h3n2) viruses, and were genetically distinct from a/new york/39/2012(h3n2) of 2014/15 vaccine strain in japan, which was classified as clade 3c.1. we assessed vaccine effectiveness (ve) of inactivated influenza vaccine (iiv) in children aged 6 months to 15 years by test-negative case-control design ba ... | 2016 | 27784529 |
| prevalence and seasonal distribution of respiratory viruses during the 2014 - 2015 season in istanbul. | acute respiratory tract infection (arti) is one of the most common infections worldwide, causing significant morbidity and mortality. | 2016 | 27800148 |
| immunogenicity of trivalent influenza vaccines in patients with chronic kidney disease undergoing hemodialysis: mf59-adjuvanted versus non-adjuvanted vaccines. | patients with chronic kidney disease (ckd) are at an increased risk of morbidity and mortality from influenza. however, the immunogenicity of influenza vaccine is known to be attenuated in these patients. in this study, the immunogenicity of mf59-adjuvanted and non-adjuvanted trivalent influenza vaccines was compared in ckd patients undergoing hemodialysis (hd). | 2016 | 27802078 |
| rates of neutropenia in adults with influenza a or b: a retrospective analysis of hospitalised patients in south east queensland during 2015. | neutropenia in adult patients is often attributed to intercurrent viral infections; however, there are limited data describing the frequency or natural history of this phenomenon. we examined all patients presenting to three large hospitals in the metro south region of south east queensland with laboratory-confirmed influenza a or b throughout the 2015 influenza season (january-october). four hundred and thirty-six patients were studied and 15.3% of this cohort were neutropenic (absolute neutrop ... | 2016 | 27813353 |
| comparative epidemiology of influenza a and b viral infection in a subtropical region: a 7-year surveillance in okinawa, japan. | the epidemic patterns of influenza b infection and their association with climate conditions are not well understood. influenza surveillance in okinawa is important for clarifying transmission patterns in both temperate and tropical regions. using surveillance data, collected over 7 years in the subtropical region of japan, this study aims to characterize the epidemic patterns of influenza b infection and its association with ambient temperature and relative humidity, in a parallel comparison wi ... | 2016 | 27821090 |
| model estimates of the burden of outpatient visits attributable to influenza in the united states. | although many studies have modelled the national burdens of hospitalizations and deaths due to influenza, few studies have considered the outpatient burden. to fill this gap for the united states (us), we applied traditional statistical modelling approaches to time series derived from large medical claims databases held in the private sector. | 2016 | 27821091 |
| genotyping and detection of common avian and human origin-influenza viruses using a portable chemiluminescence imaging microarray. | influenza viruses are divided into three types, a, b, and c. human influenza a and b viruses can cause seasonal epidemics, but influenza c causes only a mild respiratory illness. influenza a virus can infect various host species. in 2013, human-infectious avian influenza a (h7n9) was first reported in china. by the second week of 2014, there were 210 laboratory-confirmed human cases in the country, and the mortality rate eventually reached 22 %. rapid and accurate diagnosis of influenza viruses ... | 2016 | 27822445 |
| estimating the lineage dynamics of human influenza b viruses. | the prediction of the lineage dynamics of influenza b viruses for the next season is one of the largest obstacles for constructing an appropriate influenza trivalent vaccine. seasonal fluctuation of transmissibility and epidemiological interference between the two major influenza b lineages make the lineage dynamics complicated. here we construct a parsimonious model describing the lineage dynamics while taking into account seasonal fluctuation of transmissibility and epidemiological interferenc ... | 2016 | 27829058 |
| benign acute childhood myositis complicating influenza b infection in a boy with idiopathic nephrotic syndrome. | benign acute childhood myositis (bacm) is an acute complication of an infection characterized by calf pain, limitation of lower limb mobility, an increase in serum creatine kinase, and a self-limiting course. no reports of bacm in children with idiopathic nephrotic syndrome (ins) can be found in the literature. | 2016 | 27833453 |
| influenza virus infections in patients with malignancies -- characteristics and outcome of the season 2014/15. a survey conducted by the infectious diseases working party (agiho) of the german society of haematology and medical oncology (dgho). | influenza virus infections (ivi) may pose a vital threat to immunocompromised patients such as those suffering from malignancies, but specific data on epidemiology and outcome in these patients are scarce. in this study, we collected data on patients with active cancer or with a history of cancer, presenting with documented ivi in eight centres in germany. two hundred and three patients were identified, suffering from haematological malignancies or solid tumours; 109 (54 %) patients had active m ... | 2017 | 27838792 |
| evidence for influenza b virus lineage shifts and reassortants circulating in thailand in 2014-2016. | towards the surveillance of seasonal influenza viruses between august 2015 and june 2016, respiratory samples (n=3390) were collected from thai patients with influenza-like illness. one-hundred fifty-seven (4.6%) samples tested positive for influenza b virus by real-time reverse-transcription polymerase chain reaction (rt-pcr). while the influenza b virus yamagata lineage strains were more prevalent than the victoria lineage strains in 2015 (77.5% vs. 22.5%), the victoria lineage strains appeare ... | 2017 | 27845268 |
| an investigation into respiratory tract viruses in children with acute lower respiratory tract infection or wheezing. | this study aimed to determine the frequencies of respiratory tract viruses in patient (acute lower respiratory tract infection (lrti) or wheezing) and control (history of asthma without symptoms) groups. | 2016 | 27854115 |
| review of seasonal influenza in canada: burden of disease and the cost-effectiveness of quadrivalent inactivated influenza vaccines. | in the 2015/16 influenza season, the canadian national advisory committee on immunization (naci) recommended vaccination with quadrivalent inactivated influenza vaccine (qiv) for infants aged 6-23 months and trivalent inactivated influenza vaccines (tivs) or qivs in adults. the objective of this review (gsk study identifier: ho-13-14054) is to examine the epidemiology and disease burden of influenza in canada and the economic benefits of vaccination. to inform this review, we performed a systema ... | 2017 | 27858509 |
| regulation of kynurenine biosynthesis during influenza virus infection. | influenza a viruses (iavs) remain serious threats to public health because of the shortage of effective means of control. developing more effective virus control modalities requires better understanding of virus-host interactions. it has previously been shown that iav induces the production of kynurenine, which suppresses t-cell responses, enhances pain hypersensitivity and disturbs behaviour in infected animals. however, the regulation of kynurenine biosynthesis during iav infection remains elu ... | 2017 | 27860276 |
| respiratory syncytial virus and influenza are the key viral pathogens in children <2 years hospitalized with bronchiolitis and pneumonia in islamabad pakistan. | pneumonia remains a leading cause of morbidity and mortality in developing countries. comprehensive surveillance data are needed to review the prevention and control strategies. we conducted active surveillance of acute lower respiratory infections among children aged <2 years hospitalized at two hospitals of islamabad, pakistan. viral etiology was determined using real-time pcr on respiratory specimens collected during march 2011-april 2012. the overall mean age was 7.83 ± 5.25 months while no ... | 2017 | 27885562 |
| school absenteeism among school-aged children with medically attended acute viral respiratory illness during three influenza seasons, 2012-2013 through 2014-2015. | acute respiratory illnesses (aris) are common in school-aged children, but few studies have assessed school absenteeism due to specific respiratory viruses. | 2016 | 27885805 |
| influenza and rhinovirus viral load and disease severity in upper respiratory tract infections. | the role of viral load in respiratory viral infection is unclear. it is proposed that the viral load of some, but not all respiratory viruses correlate with disease severity. | 2017 | 27893998 |
| immunogenicity and safety of southern hemisphere inactivated quadrivalent influenza vaccine: a phase iii, open-label study of adults in brazil. | the world health organization influenza forecast now includes an influenza b strain from each of the influenza b lineages (b/yamagata and b/victoria) for inclusion in seasonal influenza vaccines. traditional trivalent influenza vaccines include an influenza b strain from one lineage, but because two influenza b lineages frequently co-circulate, the effectiveness of trivalent vaccines may be reduced in seasons of influenza b vaccine-mismatch. thus, quadrivalent vaccines may potentially reduce the ... | 2017 | 27912069 |
| fifteen years of epidemiologic, virologic and syndromic influenza surveillance: a focus on type b virus and the effects of vaccine mismatch in liguria region, italy. | in order to estimate the burden of influenza and to describe the genetic evolutionary pattern and antigenic variability of type b viral strains, data deriving from 3 surveillance systems active in liguria region, northern italy, were described. since the re-emergence of the victoria lineage in 2001, the clinical-epidemiological and syndromic surveillances demonstrated the heavy burden of influenza like illness (ili) syndrome. focusing on type b influenza virus, it predominated or played a releva ... | 2017 | 27924684 |
| development of high-yield influenza b virus vaccine viruses. | the burden of human infections with influenza a and b viruses is substantial, and the impact of influenza b virus infections can exceed that of influenza a virus infections in some seasons. over the past few decades, viruses of two influenza b virus lineages (victoria and yamagata) have circulated in humans, and both lineages are now represented in influenza vaccines, as recommended by the world health organization. influenza b virus vaccines for humans have been available for more than half a c ... | 2016 | 27930325 |
| generation and characterisation of monoclonal antibodies specific to avian influenza h7n9 haemagglutinin protein. | emerging virulent strains of influenza virus pose a serious public health threat with potential pandemic consequences. a novel avian influenza virus, h7n9, breached the species barrier from infected domestic poultry to humans in 2013 in china. since then, it has caused numerous infections in humans with a close contact to poultry. | 2017 | 27934828 |
| epidemiological and virological characteristics of influenza in chongqing, china, 2011-2015. | chongqing is the largest municipality and located in southwestern of china, with over 30 million registered inhabitants. there are few reports regarding the epidemiology of influenza in chongqing. the objective of the paper is to explore the epidemiology of influenza in chongqing, in order to provide scientific basis for prevention and control of influenza. | 2016 | 27936139 |
| contribution of a rapid influenza diagnostic test to manage hospitalized patients with suspected influenza. | to evaluate the performances of the alere i influenza a&b test and to appraise its contribution to patient management. | 2017 | 27939284 |
| incidence of medically attended influenza among residents of shai-osudoku and ningo-prampram districts, ghana, may 2013 - april 2015. | influenza vaccination is recommended by the world health organization for high risk groups, yet few data exist on influenza disease burden in west africa. | 2016 | 27964716 |
| parameter scaling for epidemic size in a spatial epidemic model with mobile individuals. | in recent years, serious infectious diseases tend to transcend national borders and widely spread in a global scale. the incidence and prevalence of epidemics are highly influenced not only by pathogen-dependent disease characteristics such as the force of infection, the latent period, and the infectious period, but also by human mobility and contact patterns. however, the effect of heterogeneous mobility of individuals on epidemic outcomes is not fully understood. here, we aim to elucidate how ... | 2016 | 27973605 |
| an epidemiological analysis of summer influenza epidemics in okinawa. | objective this study evaluates the difference between winter influenza and summer influenza in okinawa. methods from january 2007 to june 2014, weekly rapid antigen test (rat) results performed in four acute care hospitals were collected for the surveillance of regional influenza prevalence in the naha region of the okinawa islands. results an antigenic data analysis revealed that multiple h1n1 and h3n2 viruses consistently co-circulate in okinawa, creating synchronized seasonal patterns and a h ... | 2017 | 27980256 |
| cost-effectiveness of quadrivalent versus trivalent influenza vaccine in the united states. | designed to overcome influenza b mismatch, new quadrivalent influenza vaccines (qivs) contain one additional b strain compared with trivalent influenza vaccines (tivs). | 2016 | 27987647 |
| national influenza surveillance in the philippines from 2006 to 2012: seasonality and circulating strains. | the results of routine influenza surveillance in 13 regions in the philippines from 2006 to 2012 are presented, describing the annual seasonal epidemics of confirmed influenza virus infection, seasonal and alert thresholds, epidemic curve, and circulating influenza strains. | 2016 | 27993136 |
| seasonality of influenza and respiratory syncytial viruses and the effect of climate factors in subtropical-tropical asia using influenza-like illness surveillance data, 2010 -2012. | the seasonality of influenza and respiratory syncytial virus (rsv) is well known, and many analyses have been conducted in temperate countries; however, this is still not well understood in tropical countries. previous studies suggest that climate factors are involved in the seasonality of these viruses. however, the extent of the effect of each climate variable is yet to be defined. | 2016 | 28002419 |
| prevalence of co-infection between respiratory syncytial virus and influenza in children. | respiratory syncytial virus (rsv) and influenza have varying degree of seasonal overlap. | 2017 | 28012809 |
| extensive swelling of the limb and systemic symptoms after a fourth dose of acellular pertussis containing vaccines in england in children aged 3-6years. | extensive limb swelling (esl) after a booster dose of acellular pertussis (ap) containing vaccine can cause concern and has the potential to be confused with cellulitis. in the united kingdom ap-containing vaccine was introduced for primary immunisation at 2, 3 and 4months of age in 2004, with the first cohorts eligible to receive a fourth dose in 2007 at school entry. we assessed the frequency of esl (here defined as swelling >100mms diameter) in 973 children receiving a fourth dose of one of f ... | 2017 | 28017441 |
| evolutionary dynamic of antigenic residues on influenza b hemagglutinin. | hemagglutinin (ha) of seasonal influenza virus evolves under positive selection pressure exerted by host immunity. it was previously shown that antigenic drift in different influenza b sublineages during different time periods distributed unevenly among different epitopes, and that more recent viruses up to 2007 might have their antigenic drift more focused on certain epitope. we further analyzed whether more recent influenza b viruses up to 2016 followed that same pattern of antigenic evolution ... | 2017 | 28024225 |
| coherence of influenza surveillance data across different sources and age groups, beijing, china, 2008-2015. | influenza is active during the winter and spring in the city of beijing, which has a typical temperate climate with four clear distinct seasons. the clinical and laboratory surveillance data for influenza have been used to construct critical indicators for influenza activities in the community, and previous studies have reported varying degrees of association between laboratory-confirmed influenza specimens and outpatient consultation rates of influenza-like illness in subtropical cities. howeve ... | 2016 | 28036373 |
| intraseason waning of influenza vaccine protection: evidence from the us influenza vaccine effectiveness network, 2011-12 through 2014-15. | recent studies suggest that influenza vaccine effectiveness (ve) may wane over the course of an influenza season, leading to suboptimal ve during late influenza seasons. | 2017 | 28039340 |
| flutracking weekly online community survey of influenza-like illness annual report, 2015. | flutracking is a national online community influenza-like illness (ili) surveillance system that monitors weekly ili activity and impact in the australian community. this article reports on the 2015 findings from flutracking. from 2014 to 2015 there was a 38.5% increase in participants to 27,824 completing at least 1 survey with a peak weekly response of 25,071 participants. the 2015 flutracking national ili weekly fever and cough percentages peaked in late august at 5.0% in the unvaccinated gro ... | 2016 | 28043226 |
| influenza epidemiology in patients admitted to sentinel australian hospitals in 2015: the influenza complications alert network. | the influenza complications alert network (flucan) is a sentinel hospital-based surveillance program that operates at sites in all states and territories in australia. this report summarises the epidemiology of hospitalisations with laboratory-confirmed influenza during the 2015 influenza season. in this observational study, cases were defined as patients admitted to one of the sentinel hospitals with an acute respiratory illness with influenza confirmed by nucleic acid detection. during the per ... | 2016 | 28043227 |
| influenza b burden during seasonal influenza epidemics in france. | seasonal flu outbreaks are linked to the circulation of influenza virus type a or b. special attention has always been paid to influenza a epidemics; but recently, several studies have investigated the impact of influenza b virus epidemics, particularly as, since the 1980s, two antigenically different influenza b lineages co-circulate, raising the issue of vaccine matching. | 2017 | 28062245 |
| time to change dosing of inactivated quadrivalent influenza vaccine in young children: evidence from a phase iii, randomized, controlled trial. | children under 3 years of age may benefit from a double-dose of inactivated quadrivalent influenza vaccine (iiv4) instead of the standard-dose. | 2017 | 28062552 |
| antisynthetase syndrome and influenza b, characteristic pulmonary involvement. | 2017 | 28063779 | |
| spatio-temporal patterns of proportions of influenza b cases. | we studied the spatio-temporal patterns of the proportions of influenza b cases out of all typed cases, with data from 139 countries and regions downloaded from the flunet compiled by the world health organization, from january 2006 to october 2015. we restricted our analysis to 34 countries that reported more than 2,000 confirmations for each of types a and b over the study period. globally, we found that pearson's correlation is greater than 0.6 between effective distance from mexico and the p ... | 2017 | 28067277 |
| evaluation of the point-of-care becton dickinson veritor™ rapid influenza diagnostic test in kenya, 2013-2014. | we evaluated the performance of the becton dickinson veritor™ system flu a + b rapid influenza diagnostic test (ridt) to detect influenza viruses in respiratory specimens from patients enrolled at five surveillance sites in kenya, a tropical country where influenza seasonality is variable. | 2017 | 28077093 |
| [differential diagnosis of the viral etiology of suspected mumps in a population with high vaccine coverage]. | in this study, buccal swabs from patients with the clinical picture of parotitis epidemica in whom mumps virus (mv) infection was not confirmed by direct detection or serologically were tested. the aim was to detect by molecular methods nucleic acids (nas) of other respiratory viruses possibly involved in salivary gland swelling. at the same time, paired sera, if available, were tested. | 2016 | 28078898 |
| influenza a(h1n1)pdm 2009 and influenza b virus co-infection in hospitalized and non-hospitalized patients during the 2015-2016 epidemic season in israel. | influenza a and b viruses co-infections are rare events and mainly occurred in immunocompromised patients. | 2017 | 28088665 |
| preexisting immunity, not frailty phenotype, predicts influenza postvaccination titers among older veterans. | both preexisting immunity to influenza and age have been shown to be correlates of influenza vaccine responses. frailty, an indicator of functional impairment in older adults, was also shown in one study to predict lower influenza vaccine responses among nonveterans. in the current study, we aimed to determine the associations between frailty, preexisting immunity, and immune responses to influenza vaccine among older veterans. we studied 117 subjects (age range, 62 to 95 years [median age, 81 y ... | 2017 | 28100496 |
| a broadly protective therapeutic antibody against influenza b virus with two mechanisms of action. | influenza b virus (ibv) causes annual influenza epidemics around the world. here we use an in vivo plasmablast enrichment technique to isolate a human monoclonal antibody, 46b8 that neutralizes all ibvs tested in vitro and protects mice against lethal challenge of all ibvs tested when administered 72 h post infection. 46b8 demonstrates a superior therapeutic benefit over tamiflu and has an additive antiviral effect in combination with tamiflu. 46b8 binds to a conserved epitope in the vestigial e ... | 2017 | 28102191 |
| occurrence of atypical hus associated with influenza b. | hemolytic uremic syndrome (hus) is a disease characterized by thrombotic microangiopathy with a triad of non-immune hemolytic anemia, thrombocytopenia, and renal impairment. approximately 10% of cases of hus are classified as atypical (ahus). while today many genetically forms of ahus pathology are known, only about 50% of carriers precipitate the disease. the reason remains unclear, and triggering events like intercurrent infections have been postulated. in rare cases, influenza a is the known ... | 2017 | 28110418 |
| influenza a virus upregulates prpf8 gene expression to increase virus production. | a ddrt-pcr analysis was performed to detect cellular genes that are differentially expressed after influenza a virus (h1n1) infection of a549 cells. after ddrt-pcr, eight dna fragments were identified. prpf8, one of the cellular genes that were upregulated after virus infection, was further analyzed since it has previously been identified as a cellular factor required for influenza virus replication. the upregulation of prpf8 gene expression after viral infection was confirmed using real-time rt ... | 2017 | 28110426 |
| the use of saliva specimens for detection of influenza a and b viruses by rapid influenza diagnostic tests. | diagnostic tests for influenza infection commonly use nasopharyngeal swabs (nps) even though these are invasive to obtain. as an alternative specimen, we evaluated the diagnostic usefulness of saliva samples with rapid influenza diagnostic tests (ridts). | 2017 | 28111058 |
| aurantiamide acetate from baphicacanthus cusia root exhibits anti-inflammatory and anti-viral effects via inhibition of the nf-κb signaling pathway in influenza a virus-infected cells. | baphicacanthus cusia root also names "nan ban lan gen" has been traditionally used to prevent and treat influenza a virus infections. here, we identified a peptide derivative, aurantiamide acetate (compound e17), as an active compound in extracts of b. cusia root. although studies have shown that aurantiamide acetate possesses antioxidant and anti-inflammatory properties, the effects and mechanism by which it functions as an anti-viral or as an anti-inflammatory during influenza virus infection ... | 2017 | 28119097 |
| an in vitro fluorescence based study of initiation of rna synthesis by influenza b polymerase. | influenza polymerase replicates, via a complementary rna intermediate (crna), and transcribes the eight viral rna (vrna) genome segments. to initiate rna synthesis it is bound to the conserved 5΄ and 3΄ extremities of the vrna or crna (the 'promoter'). 5΄-3΄ base-pairing in the distal promoter region is essential to position the template rna at the polymerase active site, as shown by a new crystal structure with the 3΄ end threading through the template entry tunnel. we develop fluorescence pola ... | 2017 | 28126917 |
| alkyl polyglycoside, a highly promising adjuvant in intranasal split influenza vaccines. | influenza viral infections are significant global public health concerns due to the morbidity and mortality associated with acute respiratory disease, secondary complications, and pandemic threats; thus, continuous efforts have been made to develop potent influenza vaccines. in this study, 3 different mucosal adjuvants-alkyl polyglycoside (apg), gellan gum, and chitosan (cs)-were evaluated for their efficacy in intranasal a/h1n1 or b split influenza vaccines administered to balb/c mice. protecti ... | 2017 | 28129034 |
| whole-genome phylogenetic analysis of influenza b/phuket/3073/2013-like viruses and unique reassortants detected in malaysia between 2012 and 2014. | reassortment of genetic segments between and within influenza b lineages (victoria and yamagata) has been shown to generate novel reassortants with unique genetic characteristics. based on hemagglutinin (ha) and neuraminidase (na) genes, recent surveillance study has identified reassortment properties in b/phuket/3073/2013-like virus, which is currently used in the who-recommended influenza vaccine. to understand the potential reassortment patterns for all gene segments, four b/phuket/3073/2013- ... | 2017 | 28129386 |
| respiratory viruses in acute exacerbations of chronic obstructive pulmonary disease. | acute exacerbations of chronic obstructive pulmonary disease (aecopd) cause significant morbidity, mortality, and an inexorable decline of lung function. data from developed countries have shown viruses to be important causes of aecopd, but data from developing countries like india are scant. we set out to determine the contribution of viruses in the causation of hospitalized patients with aecopd. | 2017 | 28144057 |
| excess mortality associated with influenza after the 2009 h1n1 pandemic in a subtropical city in china, 2010-2015. | the aim of this study was to use a quasi-poisson regression model to estimate the mortality burden associated with influenza type/subtypes in a subtropical city in china, for the years 2010-2015. | 2017 | 28167255 |
| rapid molecular detection and differentiation of influenza viruses a and b. | influenza is a contagious respiratory illness caused by influenza viruses a and b in humans and causes a significant amount of morbidity and mortality every year. the influenza a and b assay was the first clia-waived molecular rapid flu test available. the influenza a and b test works by employing isothermal amplification with influenza-specific primers followed by target detection with molecular beacon probes. here, the performance of the influenza a and b assay on frozen, archived nasopharynge ... | 2017 | 28190065 |