Publications
| Title | Abstract | Year Filter | PMID(sorted ascending) Filter |
|---|
| estimating the prevalence of coinfection with influenza virus and the atypical bacteria bordetella pertussis, chlamydophila pneumoniae, and mycoplasma pneumoniae. | coinfections with common bacterial respiratory pathogens and influenza viruses are well-known causes of disease, often via synergistic interactions between the influenza virus, the bacteria, and the human host. however, relatively little is known about interactions between atypical bacteria and influenza viruses. a recent report by reinton et al. explored this issue by analyzing data from 3,661 patients seeking medical assistance for the presence of mycoplasma pneumoniae, chlamydophila pneumonia ... | 2014 | 24789653 |
| recent advances in technologies for developing drugs against chlamydia pneumoniae. | the unique morphological characteristics, capacity of manipulating host cell function and association with chronic inflammatory diseases represent the features of chlamydia pneumoniae that have fascinated scientists and medical professionals for several decades. | 2014 | 24792993 |
| imaging of chlamydia and host cell metabolism. | chlamydial infections cause a wide range of acute and chronic diseases. chlamydia trachomatis is the most common sexually transmitted bacterium while chlamydia pneumoniae causes infections of the upper and lower respiratory tract. chlamydia are obligate, intracellular bacteria with a biphasic developmental cycle that involves unique metabolic changes. aside from entering an actively replicating state, chlamydia may also implement persistent infections depending on different microenvironmental fa ... | 2014 | 24810350 |
| a case-control study examining association between infectious agents and acute myocardial infarction. | coronary heart disease is multi-factorial in origin and its burden is expected to rise in developing countries, including india. evidence suggests that the inflammation caused by infection is associated with the development of atherosclerosis and heart disease. an increasing number of clinical and experimental studies point to a contribution of various infectious organisms to the development of atherosclerosis in humans. acute myocardial infarction (ami) is associated with atherosclerosis. | 2015 | 24820983 |
| chlamydia pneumoniae infection of lungs and macrophages indirectly stimulates the phenotypic conversion of smooth muscle cells and mesenchymal stem cells: potential roles in vascular calcification and fibrosis. | two hallmarks of advanced atherosclerosis are calcification and fibrosis. we hypothesized that chlamydia pneumoniae infection may contribute to atherosclerosis by inducing the conversion of vascular smooth muscle cells to calcifying cells or by converting mesenchymal stem cells to osteochondrocytic or fibroblastic phenotypes. in this study, direct infection of bovine aortic smooth muscle cells (bsmcs) did not induce the expression of alkaline phosphatase or the deposition of extracellular calciu ... | 2014 | 24833344 |
| [detection of serum chlamydia pneumoniae antibodies and analysis of epidemiologic data in 5 years]. | to detect serum chlamydia pneumoniae (c.pneumonia) antibodies and analyze the epidemiologic data. | 2014 | 24854912 |
| chlamydia pneumoniae disrupts lipid metabolism in human umbilical vein endothelial cells. | atherosclerosis is well established as a chronic inflammatory disorder, and chlamydia pneumoniae is considered to be a risk factor for atherosclerotic development. endothelial dysfunction, caused by oxidized low‑density lipoprotein (ox‑ldl) is an early atherosclerotic marker. however, the effect of c. pneumoniae on lipid metabolism in vascular endothelial cells is yet to be elucidated. the aim of the present study was to investigate the effects of c. pneumoniae on lipid metabolism in human umbil ... | 2014 | 24898283 |
| a study on the association between infectious burden and alzheimer's disease. | previous studies suggested that the overall burden of prior infections contributes to cardiovascular diseases and stroke. in the present study, the association between infectious burden (ib) and alzheimer's disease (ad) was examined. | 2015 | 24910016 |
| erythema nodosum in children: evaluation of 39 patients. | erythema nodosum (en) has been associated with various infectious and noninfectious diseases. a total of 39 en patients seen between may 2005 and february 2012 were evaluated retrospectively in this study. the etiology of en was established in 22 of the 39 children (56.4%). streptococcal infection was the most common cause (23%), followed by tularemia (10.2%) and tuberculosis (latent tuberculosis infection (ltbi) 5%, pulmonary tuberculosis 2.5%). miscellaneous conditions were as follows: behçet ... | 2014 | 24911847 |
| efficacy and safety of garenoxacin tablets on clinically diagnosed atypical pneumonia: postmarketing surveillance in japan. | we performed a postmarketing surveillance study to determine the efficacy and safety of the oral quinolone antibacterial agent garenoxacin (geninax(®) tablets 200 mg) against atypical pneumonia. between october 2009 and july 2011, patients with community-acquired pneumonia visited 26 facilities in japan; we collected survey forms from 105 of these patients who were suspected of having atypical pneumonia based on the japanese respiratory society guidelines for the management of community-acquired ... | 2014 | 24934886 |
| amia is a penicillin target enzyme with dual activity in the intracellular pathogen chlamydia pneumoniae. | intracellular chlamydiaceae do not need to resist osmotic challenges and a functional cell wall was not detected in these pathogens. nevertheless, a recent study revealed evidence for circular peptidoglycan-like structures in chlamydiaceae and penicillin inhibits cytokinesis, a phenomenon known as the chlamydial anomaly. here, by characterizing a cell wall precursor-processing enzyme, we provide insights into the mechanisms underlying this mystery. we show that amia from chlamydia pneumoniae sep ... | 2014 | 24953137 |
| chlamydia pneumoniae negatively regulates abca1 expression via tlr2-nuclear factor-kappa b and mir-33 pathways in thp-1 macrophage-derived foam cells. | atp-binding cassette transporter a1 (abca1) is critical in exporting cholesterol from macrophages and plays a protective role in the development of atherosclerosis. this study was to determine the effects and potential mechanisms of chlamydia pneumoniae (c. pneumoniae) on abca1 expression and cellular cholesterol efflux in thp-1 macrophage-derived foam cells. | 2014 | 24953492 |
| chlamydia pneumoniae copd translocator protein plays a critical role in type iii secretion (t3s) and infection. | pathogenic gram-negative bacteria use type iii secretion (t3s) to inject effector proteins into the host cell to create appropriate conditions for infection and intracellular replication. chlamydia spp. are believed to use t3s to infect their host cell, and the translocator proteins are an essential component of this system. chlamydia pneumoniae contains genes encoding two sets of translocator proteins; copb and copd, and copb2 and copd2. in this study, we identified novel interactions between c ... | 2014 | 24959658 |
| zoledronic acid affects the cytotoxic effects of chlamydia pneumoniae and the modulation of cytokine production in human osteosarcoma cells. | chlamydia pneumoniae is an obligate intracellular gram-negative bacterium that causes persistent infections with a tendency to chronicize, which might motivate the resistance of chlamydiae to some commonly used antibiotics. the bisphosphonates are an emerging class of drugs mostly used in the palliative care of cancer patients to inhibit proliferation and metastasis of cancer cells but their role in modulating immune responses remains unknown. we investigated the in vitro activity of a highly po ... | 2014 | 24975838 |
| detection of chlamydophila pneumoniae antigens in children in the lower silesia region in 2011. | the majority of chlamydophila pneumoniae infections are asymptomatic. symptomatic infections due to c. pneumoniae are associated with upper and lower respiratory tract infections. | 2014 | 24979513 |
| all subtypes of the pmp adhesin family are implicated in chlamydial virulence and show species-specific function. | the bacterial pathogens chlamydia trachomatis and c. pneumoniae are obligate intracellular parasites, cause a number of serious diseases, and can infect various cell types in humans. chlamydial infections are probably initiated by binding of the bacterial outer membrane protein omcb to host cell glycosaminoglycans (gags). here, we show that all nine members of the polymorphic membrane protein (pmp) family of c. trachomatis mediate adhesion to human epithelial and endothelial cells. importantly, ... | 2014 | 24985494 |
| increased sensitivity to tryptophan bioavailability is a positive adaptation by the human strains of chlamydia pneumoniae. | one of the most significant activities induced by interferon-gamma against intracellular pathogens is the induction of ido (indoleamine 2,3-dioxygenase) expression, which subsequently results in the depletion of tryptophan. we tested the hypothesis that human strains of chlamydia pneumoniae are more sensitive to tryptophan limitation than animal c. pneumoniae strains. the human strains were significantly more sensitive to ifn-γ than the animal strains in a lung epithelia cell model (beas-2b), wi ... | 2014 | 24989637 |
| [chlamydia pneumoniae persistent infection is associated with primary iga nephropathy]. | to explore the correlations between chlamydia pneumoniae (cp) infection and iga nephropathy (igan). | 2014 | 25001944 |
| infectious burden and atherosclerosis: a clinical issue. | atherosclerotic cardiovascular diseases, chronic inflammatory diseases of multifactorial etiology, are the leading cause of death worldwide. in the last decade, more infectious agents, labeled as "infectious burden", rather than any single pathogen, have been showed to contribute to the development of atherosclerosis through different mechanisms. some microorganisms, such as chlamydia pneumoniae (c. pneumoniae), human cytomegalovirus, etc. may act directly on the arterial wall contributing to en ... | 2014 | 25032197 |
| clinical characteristics of q fever and etiology of community-acquired pneumonia in a tropical region of southern taiwan: a prospective observational study. | the clinical characteristics of q fever are poorly identified in the tropics. fever with pneumonia or hepatitis are the dominant presentations of acute q fever, which exhibits geographic variability. in southern taiwan, which is located in a tropical region, the role of q fever in community-acquired pneumonia (cap) has never been investigated. | 2014 | 25033402 |
| biochemical and structural insights into microtubule perturbation by copn from chlamydia pneumoniae. | although the actin network is commonly hijacked by pathogens, there are few reports of parasites targeting microtubules. the proposed member of the lcre protein family from some chlamydia species (e.g. pcopn from c. pneumoniae) binds tubulin and inhibits microtubule assembly in vitro. from the pcopn structure and its similarity with that of mxic from shigella, we definitively confirm copn as the chlamydia homolog of the lcre family of bacterial proteins involved in the regulation of type iii sec ... | 2014 | 25056950 |
| serological association of chlamydia pneumoniae infection with age-related macular degeneration: a systematic review and meta-analysis. | we investigated the serological association of chlamydia pneumoniae infection with age-related macular degeneration (amd). | 2014 | 25062085 |
| higher titers of anti-chlamydia pneumoniae igg in diabetic retinopathy: a cross-sectional study. | chronic inflammation has a role in the pathogenesis of diabetic retinopathy. infection with intracellular organisms may incite chronic inflammation. this study was conducted to investigate the association between previous infection with chlamydia pneumoniae (an intracellular microorganism) and diabetic retinopathy. | 2015 | 25066224 |
| [clinical and immunological factors of the onset and development of age-related macular degeneration]. | the purpose of the study is to determine the role of certain clinical and immunological factors of the onset and development of age-related macular degeneration (amd). | 2014 | 25098114 |
| c. pneumoniae disrupts enos trafficking and impairs no production in human aortic endothelial cells. | endothelial nitric oxide synthase (enos) generated no plays a crucial physiological role in the regulation of vascular tone. enos is a constitutively expressed synthase whose enzymatic function is regulated by dual acylation, phosphorylation, protein-protein interaction and subcellular localization. in endothelial cells, the enzyme is primarily localized to the golgi apparatus (ga) and the plasma membrane where it binds to caveolin-1. upon stimulation, the enzyme is translocated from the plasma ... | 2015 | 25131610 |
| the probable role of cytomegalovirus in acute myocardial infarction. | coronary artery disease (cad) is the most common cause of death worldwide and many studies have been performed on reduction of its prevalence. | 2014 | 25147687 |
| the wobbly status of ketolides: where do we stand? | ketolides are erythromycin a derivatives with a keto group replacing the cladinose sugar and an aryl-alkyl group attached to the lactone macrocycle. the aryl-alkyl extension broadens its antibacterial spectrum to include all pathogens responsible for community-acquired pneumonia (cap): streptococcus pneumoniae, haemophilus influenzae, moraxella catarrhalis as well as atypical pathogens (mycoplasma pneumoniae, chlamydia pneumoniae, legionella pneumophila). ketolides have extensive tissue distribu ... | 2014 | 25154307 |
| glycemic control in type 2 diabetes mellitus prevents coronary arterial wall infection. | diabetes mellitus (dm) is a very well-known risk factor for development of atherosclerosis, and it has been hypothesized that poor glycemic control and hyperglycemia plays a major role in this process. in the current study, we aimed to evaluate the associates of poor glycemic control in iranian patients who have already undergone coronary artery bypass grafting (cabg), with especial focus on the inhabitation of infectious agents within the coronary arterial wall. | 2014 | 25161684 |
| liver granulomatosis: a case of chlamydophila pneumoniae infection. | an 18-year-old man was referred to the internal medicine ward because of a 2-week history of intermittent high fever, weight loss and cough. clinical examination revealed hepato-splenomegaly and multiple lymph nodes swelling while laboratory tests showed elevated c-reactive protein, gamma glutamyl transferase and lactate dehydrogenase. all serologic testes for auto-immune antibodies, viruses and bacteria were negative except for chlamydophila pneumoniae. an 18-fdg pet computed tomography scanner ... | 2015 | 25176557 |
| [etiology of community-acquired pneumonia in children hospitalized in the period of 2009-2012]. | the aim of this study was to analyze etiology of childhood pneumonia in the region of warsaw and to assess the efficacy and usefulness of standard diagnostic procedures used in search of etiology. | 2014 | 25182260 |
| bacterial infection and alzheimer's disease: a meta-analysis. | the possibility of an infectious etiology for alzheimer's disease (ad) has been repeatedly postulated over the past three decades. we provide the first meta-analysis to address the relationship between bacterial infection and ad. studies examining the association between ad and spirochetal bacteria or chlamydophila pneumoniae (cpn) were identified through a systematic search of the databases medline, embase, pubmed, and google scholar. data combined from 25 relevant, primarily case-control studi ... | 2015 | 25182736 |
| chlamydia pneumoniae harness host nlrp3 inflammasome-mediated caspase-1 activation for optimal intracellular growth in murine macrophages. | chlamydia pneumoniae is an obligate intracellular pathogen that replicates within a vacuole and acquires host cell nutrients. we show that c. pneumoniae utilizes host innate immune signaling nlrp3/asc/caspase-1 inflammasome for intracellular growth. bone marrow-derived macrophages (bmms) secreted mature interleukin-1β upon infection with c. pneumoniae depending on the nlrp3 inflammasome activation. intracellular growth of c. pneumoniae was severely impaired in bmms from nlrp3(-/-), asc(-/-), and ... | 2014 | 25193701 |
| dendritic cells from aged subjects display enhanced inflammatory responses to chlamydophila pneumoniae. | chlamydophila pneumoniae (cpn) is a common respiratory pathogen that causes a chronic and persistent airway infection. the elderly display an increased susceptibility and severity to this infection. however, the underlying mechanisms are not well understood. dendritic cells (dcs) are the initiators and regulators of immune responses. therefore, we investigated the role of dcs in the age-associated increased cpn infection in vitro in humans. though the expression of activation markers was compara ... | 2014 | 25253920 |
| novel inflammatory biomarkers and their correlation to chlamydia pneumoniae titres in acute ischemic stroke. | young stroke patients constitute 15%-30% of all stroke patients in india as against 3.0%-8.5% reported from the west. the mechanisms for stroke in the young may include unconventional risk factors such as infections. we aimed to investigate the role (if any) of chlamydia pneumoniae antibodies in young patients with acute ischemic stroke (ais). several proinflammatory cytokines and biomarkers are released early after the onset of brain ischemia. we assessed the role of heat shock protein (hsp) 65 ... | 2014 | 25263435 |
| in vitro activity of azd0914, a novel dna gyrase inhibitor, against chlamydia trachomatis and chlamydia pneumoniae. | the in vitro activities of azd0914, levofloxacin, azithromycin, and doxycycline against 10 isolates each of chlamydia trachomatis and chlamydia pneumoniae were tested. for azd0914, the mic90s for c. trachomatis and c. pneumoniae were 0.25 μg/ml (range, 0.06 to 0.5 μg/ml) and 1 μg/ml (range, 0.25 to 1 μg/ml), respectively, and the minimal bactericidal concentrations at which 90% of the isolates were killed (mbc90s) were 0.5 μg/ml for c. trachomatis (range, 0.125 to 1 μg/ml) and 2 μg/ml for c. pne ... | 2014 | 25288086 |
| [travel-associated pneumonias]. | respiratory infections are responsible for up to 11% of febrile infections in travellers or immigrants from tropical and subtropical regions. the main pathogens are the same as in temperate climate zones: streptococcus pneumoniae, haemophilus influenzae, mycoplasma pneumoniae, chlamydophila pneumoniae, influenza viruses, legionella pneumophila. however, some pulmonary diseases can be attributed to bacterial, parasitic, viral or fungal pathogens that are endemic in tropical and subtropical region ... | 2014 | 25290923 |
| chlamydophila pneumonia and increased tlr4 gene expression in leukocytes are associated with acute myocardial infarction. | we investigated the relationship of the positivity for chlamydophila pneumoniae (cpn) and mycoplasma pneumonia (mpn), inflammatory and metabolic markers, and mrna expression and polymorphisms of the tlr2, tlr4, il-6 and tnfa genes with acute myocardial infarction (ami). two hundred and eighteen individuals (98 ami and 120 non-ami) were selected at two clinical centers. blood samples were drawn to extract dna and rna and to measure laboratory variables including anti-cpn igm and igg. cpn and mpn ... | 2014 | 25316132 |
| shear stress upregulates il-1β secretion by chlamydia pneumoniae- infected monocytes. | infectious agents are increasingly implicated in the development and progression of chronic inflammatory diseases. several lines of evidence suggest that the common intracellular respiratory pathogen, chlamydia pneumoniae contributes to the well-established risk factors of atherosclerosis but the exact mechanism is not well understood. it is believed that c. pneumoniae-infected monocytes travel from the lung to the atherosclerotic foci, during which the cells experience mechanical stimuli due to ... | 2015 | 25336058 |
| influence of intimal chlamydophila pneumoniae persistence on cardiovascular complications after coronary intervention. | chlamydophila pneumoniae has been implicated in atherosclerosis/restenosis; however, clear evidence is missing. therefore, the aim of our study was to examine the influence of intimal infection and systemic inflammation on cardiovascular complications after coronary intervention. | 2015 | 25344890 |
| the etiology of juvenile idiopathic arthritis. | over the years, the commonly used term to describe juvenile idiopathic arthritis (jia) has changed. by definition, jia includes all types of arthritis with no apparent cause, lasting more than 6 weeks, in patients aged less than 16 years at onset. jia pathogenesis is still poorly understood: the interaction between environmental factors and multiple genes has been proposed as the most relevant working mechanism to the development of jia. the concept that various microbes that colonize or infect ... | 2015 | 25384710 |
| stevens-johnson syndrome/erythema multiforme major and chlamydia pneumoniae infection in young patients. | erythema multiforme major (emm) is an acute, self-limited mucocutaneous disease characterized by the abrupt onset of symmetrical fixed red papules evolving to target lesions. it is triggered mainly by infections, such as herpes simplex virus (hsv) and mycoplasma pneumoniae, or drugs. in instances of extensive skin lesions with "giant" targets, prominent involvement of several mucous sites and fever, it may be difficult to distinguish from stevens-johnson syndrome (sjs), a rarer, life-threatening ... | 2010 | 25386242 |
| the role of chlamydia pneumoniae in the etiology of keratoconjunctivitis sicca (kcs). | the authors aimed to show the possible relationship between keratoconjunctivitis sicca (kcs) and chlamydia pneumonia from the point of view of clinical and microbiological diagnostics. | 2014 | 25395268 |
| [serological evidence of infection by three species of chlamydia in pregnant women in mexico]. | background: chlamydiales are obligate intracellular pathogens causing a wide range of diseases in humans and animals. | 2014 | 25412551 |
| a prospective study on bacterial and atypical etiology of acute exacerbation in chronic obstructive pulmonary disease. | the bacterial and atypical etiology of acute exacerbations of chronic obstructive pulmonary disease was investigated and the diagnostic techniques used were compared among 92 hospitalized patients. | 2014 | 25437187 |
| infection-related asthma. | the role of infection in asthma is varied in that it may exacerbate established asthma or contribute to the initial development of the clinical onset of asthma. mounting evidence implicates both roles with particular viral pathogens, namely human rhinovirus and respiratory syncytial virus, among the most likely culprits in asthma inception. once asthma is present, infection, particularly viral infection, is a common precipitant of asthma exacerbations. bacterial infections and colonization also ... | 2014 | 25439354 |
| previous infection and the risk of ischaemic stroke in italy: the in2 study. | there is an increasing interest in new risk factors for ischaemic stroke. acute and chronic infections could contribute to different aetiological mechanisms of atherosclerosis that lead to cerebrovascular disease. the aim of this study was to investigate the hypothesis that previous infections and chlamydia pneumoniae in particular increase the risk of ischaemic stroke in the population. | 2015 | 25443877 |
| genetic diversity of chlamydia among captive birds from central argentina. | to study the occurrence of chlamydia spp. and their genetic diversity, we analysed 793 cloacal swabs from 12 avian orders, including 76 genera, obtained from 80 species of asymptomatic wild and captive birds that were examined with conventional nested polymerase chain reaction and quantitative polymerase chain reaction. chlamydia spp. were not detected in wild birds; however, four species (chlamydia psittaci, chlamydia pecorum, chlamydia pneumoniae and chlamydia gallinacea) were identified among ... | 2015 | 25469538 |
| chlamydophila pneumoniae infection assessment in children with adenoid hypertrophy concomitant with rhino sinusitis. | since adenoids may act as a reservoir for bacteria, they can cause ear infection, recurrent otitis and recurrent adenotonsillitis. therefore, adenotonsillectomy is an efficient method for reducing the number and severity of subsequent infections. | 2014 | 25485049 |
| [environmental factors: the contribution of infectious agents]. | multiple sclerosis (ms) is a multifactorial disease resulting from complex interactions between predisposing genetic and environmental factors. among the many potential environmental risk factors, several common infectious agents such as epstein-barr virus (ebv), human herpesvirus-6 and chlamydia pneumoniae(c. pneumoniae) have been causatively implicated in the onset of ms. however, with the exception of ebv, consistent data are yet to be obtained regarding the involvement of infectious agents. ... | 2014 | 25518373 |
| first report on prevalence and risk factors of severe atypical pneumonia in vietnamese children aged 1-15 years. | atypical pathogens such as mycoplasma pneumoniae, chlamydophila pneumoniae, and legionella pneumophila are increasingly recognized as important causes of community acquired pneumonia (cap) worldwide. such etiological data for vietnam is scarce and clinical doctors lack accurate information on which to base their diagnosis and treatment of pneumonia. this study identifies the prevalence and risk factors of severe community acquired pneumonia due to these atypical pathogens (severe-apcap) in child ... | 2014 | 25524126 |
| chlamydia pneumoniae effector chlamydial outer protein n sequesters fructose bisphosphate aldolase a, providing a benefit to bacterial growth. | pathogenic chlamydiae are obligate intracellular pathogens and have adapted successfully to human cells, causing sexually transmitted diseases or pneumonia. chlamydial outer protein n (copn) is likely a critical effector protein secreted by the type iii secretion system in chlamydiae, which manipulates host cells. however, the mechanisms of its action remain to be clarified. in this work, we aimed to identify previously unidentified copn effector target in host cells. | 2014 | 25528659 |
| invariant natural killer t cells promote t cell immunity by modulating the function of lung dendritic cells during chlamydia pneumoniae infection. | in this study, we examined the effect of invariant natural killer t (inkt) cells on the function of lung dendritic cells (ldcs) in eliciting protective immunity against chlamydia pneumoniae (cpn) lung infection. we employed a combination of approaches including the use of inkt cell-deficient, jα18-knockout (ko) mice and ldc adoptive transfer. we found that inkt cells significantly altered the number, phenotype and cytokine profile of ldcs following infection. furthermore, coculture of t cells wi ... | 2015 | 25531453 |
| detection of bacterial antigens and alzheimer's disease-like pathology in the central nervous system of balb/c mice following intranasal infection with a laboratory isolate of chlamydia pneumoniae. | pathology consistent with that observed in alzheimer's disease (ad) has previously been documented following intranasal infection of normal wild-type mice with chlamydia pneumoniae (cpn) isolated from an ad brain (96-41). in the current study, balb/c mice were intranasally infected with a laboratory strain of cpn, ar-39, and brain and olfactory bulbs were obtained at 1-4 months post-infection (pi). immunohistochemistry for amyloid beta or cpn antigens was performed on sections from brains of inf ... | 2014 | 25538615 |
| distinct gene signatures in aortic tissue from apoe-/- mice exposed to pathogens or western diet. | atherosclerosis is a progressive disease characterized by inflammation and accumulation of lipids in vascular tissue. porphyromonas gingivalis (pg) and chlamydia pneumoniae (cp) are associated with inflammatory atherosclerosis in humans. similar to endogenous mediators arising from excessive dietary lipids, these gram-negative pathogens are pro-atherogenic in animal models, although the specific inflammatory/atherogenic pathways induced by these stimuli are not well defined. in this study, we id ... | 2014 | 25540039 |
| chlamydia pneumoniae infection of monocytes in vitro stimulates innate and adaptive immune responses relevant to those in alzheimer's disease. | alzheimer's disease (ad) is a progressive neurodegenerative disorder in which infection with chlamydia pneumoniae (cpn) has been associated. cpn is an obligate intracellular respiratory pathogen that may enter the central nervous system (cns) following infection and trafficking of monocytes through the blood-brain barrier. following this entry, these cells may secrete pro-inflammatory cytokines and chemokines that have been identified in the ad brain, which have been thought to contribute to ad ... | 2014 | 25540075 |
| [diagnostic approach of intracellular bacteria and fastidious microorganisms]. | obligate or facultative intracellular bacteria are fastidious organisms that do not or poorly grow on conventional culture media. some of them may be the cause of frequent and potentially severe infections, such as tuberculosis (myco- bacterium tuberculosis), community-acquired respiratory infections (legionella spp., mycoplasma pneumoniae, chlamydia pneumoniae) or blood culture-negative endocarditis (coxiella burnetii, bartonella spp., tropheryma whipplei). the objective of this paper is to pro ... | 2014 | 25549373 |
| chlamydia pneumoniae and oxidative stress in cardiovascular disease: state of the art and prevention strategies. | chlamydia pneumoniae, a pathogenic bacteria responsible for respiratory tract infections, is known as the most implicated infectious agent in atherosclerotic cardiovascular diseases (cvds). accumulating evidence suggests that c. pneumoniae-induced oxidative stress may play a critical role in the pathogenesis of cvds. indeed, the overproduction of reactive oxygen species (ros) within macrophages, endothelial cells, platelets and vascular smooth muscle cells (vsmcs) after c. pneumoniae exposure, h ... | 2014 | 25561227 |
| erythema multiforme associated with chlamydophila pneumoniae infection: a report of two cases and a mini-literature review. | 2015 | 25572113 | |
| recombinant cpn 0810 stimulates proinflammatory cytokine expression and apoptosis in human monocytes. | the aim of the present study was to express the recombinant chlamydophila pneumoniae (c. pneumoniae) protein, cpn 0810, in escherichia coli (e. coli) bl21, and investigate the effects of cpn 0810 on inflammatory and apoptotic processes in human monocytic (thp-1) cells. an elisa was performed to detect the levels of the proinflammatory cytokines, tumor necrosis factor (tnf)-α and interleukin (il)-6. in addition, hoechst 33258 staining and annexin v binding analyses were performed to measure the r ... | 2015 | 25574216 |
| treatment of chlamydial infections: 2014 update. | chlamydiae are obligate intracellular bacterial pathogens whose entry into mucosal epithelial cells is required for intracellular survival and subsequent growth. the life cycle of chlamydia spp. and the ability to cause persistent, often subclinical infection, has major ramifications for diagnosis and treatment of chlamydia trachomatis and c. pneumoniae infections in humans. | 2015 | 25579069 |
| lack of effectiveness of the 23-valent polysaccharide pneumococcal vaccine in reducing all-cause pneumonias among healthy young military recruits: a randomized, double-blind, placebo-controlled trial. | streptococcus pneumoniae infections have periodically caused significant morbidity and outbreaks among military personnel, especially trainees. this study evaluated the effectiveness of the 23-valent polysaccharide pneumococcal vaccine (ppv23) in reducing pneumonia in healthy military trainees. | 2015 | 25579777 |
| the prevalence and clinical significance of chlamydia infection in island and mainland populations of victorian koalas (phascolarctos cinereus). | chlamydia infection is known to impact the health of koalas (phascolarctos cinereus) in new south wales (nsw) and queensland, but the clinical significance of chlamydia infections in victorian koalas is not well described. we examined the prevalence of chlamydia infection and assessed associated health parameters in two victorian koala populations known to be chlamydia positive. the same testing regimen was applied to a third victorian population in which chlamydia had not been detected. we exam ... | 2015 | 25588005 |
| the role of endoplasmic reticulum-related bip/grp78 in interferon gamma-induced persistent chlamydia pneumoniae infection. | direct interaction of chlamydiae with the endoplasmic reticulum (er) is essential in intracellular productive infection. however, little is known about the interplay between chlamydiae and the er under cellular stress conditions that are observed in interferon gamma (ifn-γ) induced chlamydial persistent infection. er stress responses are centrally regulated by the unfolded protein response (upr) under the control of the er chaperone bip/grp78 to maintain cellular homeostasis. in this study, we c ... | 2015 | 25588955 |
| persistent q fever and ischaemic stroke in elderly patients. | whether persistent or chronic q fever may act as a risk factor for stroke is unknown. a case-control study was conducted in the hospital universitario de burgos (spain) between february 2011 and december 2012. a total of 803 samples from 634 consecutive hospitalized patients ≥65 years old were tested, of whom 111 were cases (patients with prevalent or incident ischaemic stroke and/or transient ischaemic attack) and 523 were controls (patients without ischaemic stroke and/or transient ischaemic a ... | 2015 | 25630457 |
| orchitis and epididymitis in koalas (phascolarctos cinereus) infected with chlamydia pecorum. | although chlamydia causes disease of the urethra and prostate of male koalas, its impact on the testis and epididymis has not been examined. this study describes chronic-active and granulomatous orchitis and epididymitis with interstitial fibrosis associated with infection by chlamydia pecorum in 2 of 18 adult male koalas being euthanized at a koala hospital, 8 of which also had chlamydial prostatitis. by immunohistochemistry and transmission electron microscopy, chlamydial inclusions were demon ... | 2015 | 25637084 |
| exposure to cigarette smoke and chlamydia pneumoniae infection in mice: effect on infectious burden, systemic dissemination and cytokine responses: a pilot study. | cigarette smoke exposure has been considered a risk factor for infection with chlamydia pneumoniae. c. pneumoniae infection is associated with respiratory tract infection and chronic respiratory disease, which is a serious public health concern. to determine whether prior exposure to cigarette smoke worsens c. pneumoniae infection (specifically, increases infectious burden and systemic dissemination) as well as alters cytokine responses in mice, adult female c57bl/6 mice were exposed to either f ... | 2016 | 25640695 |
| risk factors for acute myocardial infarction in central india: a case-control study. | atherosclerosis is a multi-factorial disease involving the interplay of genetic and environmental factors. studies highlighting the public health importance of risk factors like chronic infections causing acute myocardial infarction (ami) in the indian context are scarce. this study was undertaken to study the association of socio-demographic and life-style factors with acute myocardial infarction in central india. | 2017 | 25657508 |
| the aetiology of pharyngotonsillitis in adolescents and adults - fusobacterium necrophorum is commonly found. | sore throat is common in primary healthcare. aetiological studies have focused on the presence of a limited number of pathogens. the aim of the present study was to investigate the presence of a wide range of bacteria and viruses, including fusobacterium necrophorum, in patients with pharyngotonsillitis and in asymptomatic controls. a prospective case control study was performed in primary healthcare in kronoberg county, sweden. patients (n=220) aged 15 to 45 years with a suspected acute pharyng ... | 2015 | 25658556 |
| human chlamydia pneumoniae isolates demonstrate ability to recover infectivity following penicillin treatment whereas animal isolates do not. | chlamydia pneumoniae strains have recently been demonstrated to have substantially different capacities to enter and recover from ifn-γ-induced persistence, depending on whether they are from human or animal host sources. here, we examined the ability of two human and two animal strains to enter and be rescued from penicillin-induced persistence. the ability to form inclusions after the addition of penicillin was much reduced in the two animal isolates (koala lpcoln, bandicoot b21) compared to t ... | 2015 | 25663156 |
| a single infection with chlamydia pneumoniae is sufficient to exacerbate atherosclerosis in apoe deficient mice. | several studies have demonstrated a strong link between chlamydia pneumoniae (cp) infection and atherosclerosis progression/exacerbation. here, we try to understand whether a single administration of cp could exacerbate atherosclerosis. apoe(-/-) mice were intranasally infected with cp followed by a high fat diet. mice were sacrificed at different time points after cp infection to monitor the development of the atheroma. cp infection increased lipid content in the aortic sinus of apoe(-/-) mice ... | 2015 | 25666507 |
| performance evaluation of two microbial transport media designed for preservation and transport of chlamydiae, mycoplasma and ureaplasma. | the ability of a non-propagating transport device (test device) to maintain the viability of clinically relevant bacteria was compared with a similar commercial device (predicate device) to establish performance equivalence. test bacteria, namely chlamydia trachomatis, chlamydia pneumoniae, mycoplasma hominis, mycoplasma pneumoniae and ureaplasma urealyticum, were inoculated into the test [puritan medical products universal transport system (unitranz-rt(tm))] and predicate (bd universal viral tr ... | 2015 | 25713205 |
| the presence of some cytokines and chlamydia pneumoniae in the atherosclerotic carotid plaque in patients with carotid artery stenosis. | over the last few years the role of microorganisms in the pathogenesis of atherosclerosis has been widely discussed. chlamydia pneumoniae activates immune cells to produce cytokines that are responsible for the formation of atheromatous carotid lesions. | 2015 | 25720609 |
| detection of chlamydophila pneumoniae and typical bacteria in patients with chronic cough. | the aim of research was to analyze the results of microbiological tests for typical and atypical bacteria in patients with symptoms of chronic cough. a total of 214 outpatients aged from 2 to 94 years (110 women, 64 men, and 40 children) with chronic cough were studied. four hundred twenty eight throat swabs were examined for atypical bacteria antigen (chlamydophila pneumoniae) (n=214) and typical pathogens (n=214). chl. pneumoniae detection was performed using indirect immunofluorescence test. ... | 2015 | 25724797 |
| enzymatic characterization of chlamydophila pneumoniae phospholipase d. | chlamydophila pneumoniae, an aetiological agent of respiratory infection, is also thought to play an immuno-pathogenetic role in atherosclerosis by contributing to inflammation and plaque instability. phospholipase d (pld) is an enzyme involved in lipid metabolism and may have a direct or indirect impact on virulence and the inflammatory response. some aspects of the developmental cycle of c. pneumoniae suggest a direct implication of its pld (cppld) in the pathogenesis, specifically by affectin ... | 2015 | 25742148 |
| berberine inhibits chlamydia pneumoniae infection-induced vascular smooth muscle cell migration through downregulating mmp3 and mmp9 via pi3k. | the mechanisms by which chlamydia pneumoniae infection promote vascular smooth muscle cell (vsmc) migration required in the development of atherosclerosis have not yet been fully clarified. matrix metalloproteinases (mmps) have important roles in vsmc migration. however, it is still unknown whether mmps are involved in c. pneumoniae infection-induced vsmc migration. in addition, whether berberine can exert its inhibitory effects on the infection-induced vsmc migration also remains unclear. accor ... | 2015 | 25746423 |
| prevalence and correlation of infectious agents in hospitalized children with acute respiratory tract infections in central china. | acute respiratory tract infections (artis) are associated with significant morbidity and mortality worldwide, especially in children under the age of 5 years. almost 2 million children die from artis each year, and most of them are from developing countries. the prevalence and correlation of pathogens in artis are poorly understood, but are critical for improving case prevention, treatment, and management. in this study, we investigated the prevalence and correlation of infectious agents in chil ... | 2015 | 25751402 |
| mast cells play an important role in chlamydia pneumoniae lung infection by facilitating immune cell recruitment into the airway. | mast cells are known as central players in allergy and anaphylaxis, and they play a pivotal role in host defense against certain pathogens. chlamydia pneumoniae is an important human pathogen, but it is unclear what role mast cells play during c. pneumoniae infection. we infected c57bl/6 (wild-type [wt]) and mast cell-deficient mice (kit(w-sh/w-sh) [wsh]) with c. pneumoniae. wsh mice showed improved survival compared with wt mice, with fewer cells in wsh bronchoalveolar lavage fluid (balf), desp ... | 2015 | 25754739 |
| genome-wide genetic investigation of serological measures of common infections. | populations and individuals differ in susceptibility to infections because of a number of factors, including host genetic variation. we previously demonstrated that differences in antibody titer, which reflect infection history, are significantly heritable. here we attempt to identify the genetic factors influencing variation in these serological phenotypes. blood samples from >1300 mexican americans were quantified for igg antibody level against 12 common infections, selected on the basis of th ... | 2015 | 25758998 |
| preparation and evaluation of monoclonal antibodies against chlamydial protease-like activity factor to detect chlamydia pneumoniae antigen in early pediatric pneumonia. | chlamydia pneumoniae causes diseases in humans, including community-acquired pneumonia, bronchitis, and sinusitis. it is also associated with atherosclerosis, coronary heart disease, and hyperlipidemia. in this study, we investigated novel materials with which to develop a sensitive and specific method to identify early c. pneumoniae infection, to allow more effective clinical treatment and prevention. we prepared novel monoclonal antibodies (mabs) against a recombinant protein equivalent to the ... | 2015 | 25761740 |
| aetiology and risk factors of community-acquired pneumonia in hospitalized patients in norway. | in norway, data on the aetiology of community-acquired pneumonia (cap) in hospitalized patients are limited. the aims of this study were to investigate the bacterial aetiology of cap in hospitalized patients in norway, risk factors for cap and possible differences in risk factors between patients with legionnaire's disease and pneumonia because of other causes. | 2016 | 25764275 |
| calcium, arms2 genotype, and chlamydia pneumoniae infection in early age-related macular degeneration: a multivariate analysis from the nagahama study. | although various risk factors have been identified for the development of age-related macular degeneration (amd), risk factors of early amd have been relatively under studied. we aimed to investigate amd risk factors by evaluating multiple factors in association with large drusen, an important component of amd, simultaneously. in a community-based cross-sectional survey in japan, 971 large drusen cases and 3,209 controls were compared for 65 variables, including systemic, environmental, and gene ... | 2015 | 25792034 |
| risk factors associated with the onset of relapsing-remitting and primary progressive multiple sclerosis: a systematic review. | multiple sclerosis (ms) is a chronic central nervous system disease with a highly heterogeneous course. the aetiology of ms is not well understood but is likely a combination of both genetic and environmental factors. approximately 85% of patients present with relapsing-remitting ms (rrms), while 10-15% present with primary progressive ms (ppms). ppms is associated with an older onset age, a different sex ratio, and a considerably more rapid disease progression relative to rrms. we systematicall ... | 2015 | 25802867 |
| the influence of previous infections and antichlamydia pneumoniae seropositivity on functional outcome in ischemic stroke patients: results from the in2 study. | although a growing attention is being paid to acute ischemic stroke patients, the correlation between clinical outcome and infectious events in this population has been poorly investigated. 749 ischemic stroke (mean age 71 years old, males 56%) patients were enrolled in this prospective case-control study by 11 italian stroke units. demographic data, vascular risk factors, previous infections and post-stroke infections (psis) were recorded. blood samples were collected and the enzyme-linked immu ... | 2015 | 25808504 |
| chlamydia pneumoniae and chlamydia trachomatis infection differentially modulates human dendritic cell line (mutz) differentiation and activation. | chlamydia trachomatis and chlamydia pneumoniae are important human pathogens that infect the urogenital/anorectal and respiratory tracts, respectively. whilst the ability of these bacteria to infect epithelia is well defined, there is also considerable evidence of infection of leucocytes, including dendritic cells (dcs). using a human dendritic cell line (mutz), we demonstrate that the infection and replication of chlamydiae inside dcs is species and serovar specific and that live infection with ... | 2015 | 25833314 |
| antibody responses of chlamydophila pneumoniae pneumonia: why is the diagnosis of c. pneumoniae pneumonia difficult? | the elnas plate chlamydophila pneumoniae commercial test kit for the detection of anti-c. pneumoniae-specific immunoglobulin m (igm), iga and igg antibodies has become available in japan recently. to determine the optimum serum collection point for the elnas plate in the diagnosis of c. pneumoniae pneumonia, we analyzed the kinetics of the antibody response in patients with laboratory-confirmed c. pneumoniae pneumonia. we enrolled five c. pneumoniae pneumonia cases and collected sera from patien ... | 2015 | 25840889 |
| [signs of microbial sensibilization in patients with various cardiovascular diseases]. | analysis of intensity of non-specific (level of sera cytokines) and specific (titers of antibodies against chlamydophila pneumoniae) factors of humoral immunity in patients with arterial hypertension and various forms of ischemic heart diseases. | 2015 | 25842957 |
| different presence of chlamydia pneumoniae, herpes simplex virus type 1, human herpes virus 6, and toxoplasma gondii in schizophrenia: meta-analysis and analytical study. | in the present study we have performed both a meta-analysis and an analytical study exploring the presence of chlamydia pneumoniae, herpes simplex virus type 1, human herpes virus 6, and toxoplasma gondii antibodies in a sample of 143 schizophrenic patients and 143 control subjects. the meta-analysis was performed on papers published up to april 2014. the presence of serum immunoglobulin g and immunoglobulin a was performed by enzyme-linked immunosorbent assay test. the detection of microbial dn ... | 2015 | 25848282 |
| temperature and host cell-dependent changes in virulence of chlamydia pneumoniae cwl029 in an optimized mouse infection model. | the obligate intracellular bacterium chlamydia (c.) pneumoniae causes respiratory infections and is associated with vascular diseases. to elucidate how temperature and host cells used for propagation alter chlamydial virulence, c. pneumoniae cwl0129 (cpn) was cultured at 35 or 37°c in two different cell lines and then applied to mice. these mice infected with differentially propagated chlamydiae showed differences in clinical score, body weight and inflammatory cytokines in the lung. our study d ... | 2015 | 25853997 |
| infection with chlamydia pneumoniae as a cause of coronary heart disease: the hypothesis is still untested. | 2015 | 25854002 | |
| chlamydia pneumoniae promotes dysfunction of pancreatic beta cells. | the human pathogen chlamydia pneumoniae has been implicated in chronic inflammatory diseases including type 2 diabetes. therefore, we designed a study to evaluate pancreatic beta cells and mast cells during chlamydial infection. our study revealed that c. pneumoniae infected mast cells significantly (p<0.005) decreased beta cell atp and insulin production, in contrast to uninfected mast cells co-cultured with beta cells. infected mast cells exhibited pyknotic nuclei and active caspase-3 and casp ... | 2015 | 25863744 |
| chlamydial heat-shock protein 60 : a marker for chronic infection with chlamydia pneumoniae in atherosclerosis: investigation of atherosclerotic coronary arteries by immunocytochemistry. | worldwide, ischemic heart disease is an important cause of death and there is an increasing number of pointers toward a causative connection between chlamydia pneumoniae and atherosclerosis. the presence, localization, and relationship to atheroma of chlamydial heat-shock protein 60 (chsp60) in coronary tissue was investigated by immunocytochemical methods and by different investigators. in the present study, for the first time, arterial segments, including the whole course of the great coronary ... | 2006 | 25868695 |
| bronchiectasis exacerbations: the role of atypical bacteria, respiratory syncytial virus and pulmonary function tests. | aside from the known role of common bacteria, there is a paucity of data regarding the possible role of atypical bacteria and viruses in exacerbations of non-cystic fibrosis bronchiectasis. | 2015 | 25874735 |
| mycoplasma pneumoniae and chlamydophila pneumoniae in hospitalized children with bronchiolitis. | bronchiolitis is an acute lower respiratory tract infection in early childhood caused mainly by different viruses. etiology of bronchiolitis have been studied in different environments and populations. respiratory syncytial virus (rsv), human metapneumovirus (hmpv), human bocavirus (hbov), human rhinoviruses (hrv) have consistently been shown to predominate. few studies however have attempted to determine whether other pathogens, particularly mycoplasma pneumoniae (mp) and chlamydophila pneumoni ... | 2015 | 25879563 |
| etiology of community-acquired pneumonia and diagnostic yields of microbiological methods: a 3-year prospective study in norway. | despite recent advances in microbiological techniques, the etiology of community-acquired pneumonia (cap) is still not well described. we applied polymerase chain reaction (pcr) and conventional methods to describe etiology of cap in hospitalized adults and evaluated their respective diagnostic yields. | 2015 | 25887603 |
| genomic factors related to tissue tropism in chlamydia pneumoniae infection. | chlamydia pneumoniae (cpn) are obligate intracellular bacteria that cause acute infections of the upper and lower respiratory tract and have been implicated in chronic inflammatory diseases. although of significant clinical relevance, complete genome sequences of only four clinical cpn strains have been obtained. all of them were isolated from the respiratory tract and shared more than 99% sequence identity. here we investigate genetic differences on the whole-genome level that are related to cp ... | 2015 | 25887605 |
| ap-1 transcription factor serves as a molecular switch between chlamydia pneumoniae replication and persistence. | chlamydia pneumoniae is a gram-negative bacterium that causes acute or chronic respiratory infections. as obligate intracellular pathogens, chlamydiae efficiently manipulate host cell processes to ensure their intracellular development. here we focused on the interaction of chlamydiae with the host cell transcription factor activator protein 1 (ap-1) and its consequence on chlamydial development. during chlamydia pneumoniae infection, the expression and activity of ap-1 family proteins c-jun, c- ... | 2015 | 25895972 |
| synergistic costimulatory effect of chlamydia pneumoniae with carbon nanoparticles on nlrp3 inflammasome-mediated interleukin-1β secretion in macrophages. | the obligate intracellular bacterium chlamydia pneumoniae is not only a causative agent of community-acquired pneumonia but is also associated with a more serious chronic disease, asthma, which might be exacerbated by air pollution containing carbon nanoparticles. although a detailed mechanism of exacerbation remains unknown, the proinflammatory cytokine interleukin-1β (il-1β) is a critical player in the pathogenesis of asthma. c. pneumoniae induces il-1β in macrophages via nacht, lrr, and pyd d ... | 2015 | 25939513 |
| dibenzocyclooctadiene lignans from schisandra spp. selectively inhibit the growth of the intracellular bacteria chlamydia pneumoniae and chlamydia trachomatis. | lignans from schisandra chinensis berries show various pharmacological activities, of which their antioxidative and cytoprotective properties are among the most studied ones. here, the first report on antibacterial properties of six dibenzocyclooctadiene lignans found in schisandra spp. is presented. the activity was shown on two related intracellular gram-negative bacteria chlamydia pneumoniae and chlamydia trachomatis upon their infection in human epithelial cells. all six lignans inhibited c. ... | 2015 | 25944533 |
| characterisation of chlamydia pneumoniae and other novel chlamydial infections in captive snakes. | chlamydiosis has been described in both free-ranging and captive reptiles. the infection usually manifests as granulomatous inflammation in inner organs such as spleen, heart, lung and liver but might also occur in asymptomatic reptiles. the aim of this study was to investigate and characterise chlamydia pneumoniae and potential other novel chlamydial infections in the choana and cloaca samples of 137 clinically healthy captive snakes from six private collections. forty eight samples from 29 ani ... | 2015 | 25944652 |
| immune-mediated leukopenia due to chlamydophila pneumoniae pneumonia. | 2015 | 25956214 |