Publications

in vivo studies on intracellular ph, focal flow, and vessel diameter in the cat cerebral cortex: effects of altered co2 and electrical stimulation.	the time course of changes in cortical tissue ph (phi) and blood flow during cortical seizures in halothane-anesthetized cats was examined. the clearance of the molecular form of umbelliferone (um) was used to estimate focal cortical blood flow (cbfu), whereas the ratio of the molecular to the ionic form of the molecule was used to concurrently calculate the local phi. resting phi and flow in normocarbic animals was 7.116 +/- 0.008 and 46 +/- 8 ml/100 g/min, respectively. respiratory induced alt ...	1987	3108271
[influence of bcg in the control of humoral deficiency induced by mastocytoma p-815].	viable bcg bacilli, in a lipid emulsion, inoculated intravenously, were capable of reverting the profound humoral immunosuppression induced in adult dba/2 mice by the mastocytoma p-815. bcg increased not only the number of hemolytic plaque forming cells, but also the serum titers of hemagglutinating igm antibodies. however, no blocking effect was detected on normal tumor progression.	1986	3108617
pulmonary clearance of pseudomonas aeruginosa in neutropenic mice. effects of systemic immunization.	systemic immunization with killed pseudomonas improves pulmonary clearance of these bacteria in normal mice. to test the effects of active systemic immunization on early pulmonary clearance of pseudomonas in neutropenic mice, balb/c mice were intraperitoneally immunized with 10(8) pseudomonas or injected with saline twice weekly for 2 wk. ten days after the last immunization, immunized and control mice received tail vein injections with either nitrogen mustard or saline daily for 3 days. two day ...	1987	3109290
inner-city survey for tuberculosis: evaluation of diagnostic methods.	a total of 1,271 persons living in a socially and economically depressed, inner-city area of vancouver, british columbia, voluntarily attended a tuberculosis case-finding campaign. chest x-ray, on-the-spot specimen of sputum, and tuberculin skin test were offered at the time of the first attendance. all 3 diagnostic methods were found to be well accepted, with 93% of the participants having an x-ray, over 95% producing a sputum specimen, and almost 95% having a tuberculin test (a quarter of thes ...	1987	3109292
movements of vesicles on microtubules.	many cytoplasmic vesicles are observed to move along microtubules. often, bidirectional movement of particles is observed on a single microtubule. we have isolated one cytoplasmic motor, kinesin, and defined another, the axoplasmic retrograde factor, which are capable of powering anionic latex beads toward the plus and minus ends of microtubules, respectively. observations of vesicle movements show that vesicles have a defined direction of movement and that vesicles copurify with a kinesin motor ...	2011	3109300
movements of vesicles on microtubules.	many cytoplasmic vesicles are observed to move along microtubules. often, bidirectional movement of particles is observed on a single microtubule. we have isolated one cytoplasmic motor, kinesin, and defined another, the axoplasmic retrograde factor, which are capable of powering anionic latex beads toward the plus and minus ends of microtubules, respectively. observations of vesicle movements show that vesicles have a defined direction of movement and that vesicles copurify with a kinesin motor ...	2011	3109300
effects in rats of dietary protein inadequacy on lactose production, milk volume and components of the lactose synthetase complex (ec 2.4.1.22).	lactose synthetase (ls) is a complex of alpha-lactalbumin and n-acetylglucosamine galactosyl transferase (gt). ls is the rate-limiting enzyme in lactose biosynthesis. lactose is the main osmotic component of milk and may thereby affect milk volume. dietary protein inadequacy reduces milk volume and lactose content. the study investigates the role of ls activity in these phenomena. lactating rats were fed adequate and inadequate amounts of protein of high (milk protein) and low (cereal protein) q ...	1987	3109312
purification and characterization of dihydrofolate reductase from soybean seedlings.	dihydrofolate reductase (dhfr; ec 1.5.1.3) was purified to homogeneity from soybean seedlings by affinity chromatography on methotrexate-aminohexyl sepharose, gel filtration on ultrogel aca-54, and blue sepharose chromatography. sodium dodecyl sulfate-polyacrylamide gel electrophoresis of the enzyme gave a single protein band corresponding to a molecular weight of 22,000. the enzyme is not a 140,000 da heteropolymer as reported by others. amino acid sequence-specific antibodies to intact human d ...	1987	3109322
studies on the rate-determining factor in testosterone hydroxylation by rat liver microsomal cytochrome p-450: evidence against cytochrome p-450 isozyme:isozyme interactions.	the aim of the present study was to examine a recent proposal that inhibitory isozyme:isozyme interactions explain why membrane-bound isozymes of rat liver microsomal cytochrome p-450 exert only a fraction of the catalytic activity they express when purified and reconstituted with saturating amounts of nadph-cytochrome p-450 reductase and optimal amounts of dilauroylphosphatidylcholine. the different pathways of testosterone hydroxylation catalyzed by cytochromes p-450a (7 alpha-hydroxylation), ...	1987	3109324
immunological relationship among glycogen-protein complexes of different species.	glycogen-protein complexes from the muscles of celerio euphorbiae and horse as well as from the livers of frog, carp and man were isolated and used as antigens. after immunization of rabbits antisera were obtained from which fractions of immunoglobulins were isolated. antibodies were used in agar immunodiffusion tests and in quantitative reaction of immunoprecipitation with glycogens. the immunoprecipitation test proved the occurrence of quantitative differences in cross reaction of complexes wi ...	1986	3109350
recombinant human tissue-type plasminogen activator therapy in acute thromboembolic stroke.	systemic fibrinolytic therapy for acute stroke is no longer recommended because of resulting systemic fibrinolysis and the risk of intracerebral hemorrhage. human tissue-type plasminogen activator (tpa) is a native enzyme that converts plasminogen to plasmin with subsequent clot lysis. the affinity for plasminogen is increased several-fold when the substrate is bound to fibrin. at appropriate dosage, "clot-specific" thrombolysis may be achieved at the surface of the thrombus without creating sys ...	1987	3112328
[biology and pathology of the heart and blood vessels. study group on cardiovascular research. vittel, 6-7 mai 1987. abstracts].		2011	3113391
histological changes following transplantation of developing teeth to more advanced functional positions.		1987	3113409
efficacy of a polyvalent protein-polysaccharide dysentery oral vaccine.		1987	3115716
investigation of a health care worker with symptomatic human immunodeficiency virus infection: an epidemiologic approach.		1987	3116462
pseudoatrophy of the brain with valproic acid monotherapy.	a patient is described who, while on valproic acid monotherapy, developed reversible shrinkage of the brain, documented by computerized tomography with associated cognitive deficit. although pseudoatrophy has been reported with steroid therapy, this is the first implication of an anticonvulsant drug in the etiology of that condition.	2011	3117347
the inhibition by valproic acid of the mitochondrial oxidation of monocarboxylic and omega-hydroxymonocarboxylic acids: possible implications for the metabolism of gamma-aminobutyric acid.	the interactions of 1-5 mm valproic acid with the hepatic fatty acid oxidation are here described. valproic acid was not substrate for hepatic peroxisomal fatty acid oxidation. its activation outside the mitochondrial matrix compartment was poor when compared to that of octanoic acid, a fatty acid containing the same number of carbones. valproic acid did not inhibit the fatty acyl-coa oxidase nor the cyanide-insensitive acyl-coa oxidation. valproic acid inhibited the mitochondrial oxidations of ...	1987	3117781
a new immunomodulating compound (as-101) with potential therapeutic application.	there has been interest in the potential of synthetic compounds to modify immune responses by imitation of cytokine action. direct administration of interleukin 2 (il-2) in conjunction with adoptive transfer of lymphokine activated killer cells has been used in the treatment of cancer, but there are toxic effects resulting from the high doses of il-2 required. we have developed a new synthetic compound, ammonium tri-chloro(dioxoethylene-o,o'-)tellurate (as-101), which has immunomodulating proper ...	1987	3118216
specific reduction of n,n-dimethylnitrosamine mutagenicity in drosophila melanogaster by dimethyl sulfoxide.	dimethyl sulfoxide (dmso) used as a solvent has been observed to complicate mutagenicity screens by interacting with tested chemicals to yield false positives or negatives. we have used dmso as a solvent in the drosophila melanogaster recessive sex-linked lethal mutation assay and find that it reduces, but does not abolish, the detectable mutagenicity of n,n-dimethylnitrosamine (dmn). its use as a solvent with procarbazine, another promutagen, shows no effect on mutagenicity in drosophila. dmso ...	2011	3119334
effects of cost sharing on physiological health, health practices, and worry.	in a randomized trial of the effects of medical insurance on spending and the health status of the nonaged, we previously reported that patients with limited cost sharing had approximately one-third less use of medical services, similar general self-assessed health, and worse blood pressure, functional far vision, and dental health than those with free care. of the 20 additional measures of physiological health studied here on 3,565 adults, people with cost sharing scored better on 12 measures a ...	2011	3119520
assessment of contractility changes in humans by transoesophageal echocardiography: the peak-systolic pressure end-systolic diameter relationship (pspesdrs).	the peak-systolic pressure end-systolic diameter relationship (pspesdrs) was determined in ten healthy subjects under general anaesthesia by using the radial artery pressure tracing (peak-systolic pressure) and transoesophageal 2d-and m-mode echocardiography (left ventricular diameters) without blocking of autonomic reflexes. left ventricular load was changed by injection of a single intravenous dose of 0.2 mg nitroglycerin (ntg). linear regression analysis showed a close linear relationship dur ...	2011	3119748
gonadotropin regulation of tissue-type and urokinase-type plasminogen activators in rat granulosa and theca-interstitial cells during the periovulatory period.	plasminogen activators (pas) are believed to be involved in ovulation. because both tissue-type plasminogen activator (tpa) and urokinase-type plasminogen activator (upa) are secreted by cultured rat granulosa cells, we have examined the activities of these proteins in ovarian homogenates as well as granulosa and theca-interstitial (ti) cells during gonadotropin-induced ovulation. immature rats were injected with 20 iu pregnant mare serum gonadotropin (pmsg) to initiate follicle development, fol ...	1987	3121412
sequential antibiotic therapy in acute leukemia.		2011	3121466
evaluation of the 11co2 positron emission tomographic method for measuring brain ph. i. ph changes measured in states of altered pco2.	the 11co2 method for measuring local brain ph with positron emission tomography (pet) has been experimentally evaluated, testing the adequacy of the kinetic model and the ability of the method to measure changes in brain ph. plasma and tissue time/activity curves measured during and following continuous inhalation of 11co2 were fit with a kinetic model that includes effects of tissue ph, blood flow, and fixation of co2 into compounds other than dissolved gas and bicarbonate ions. for each of ten ...	1987	3121647
[24-hour efficacy of a system of transcutaneous administration of nitroglycerin. evaluation by the exercise test and gamma angiography].	the effects of a nitroglycerin transdermal therapeutic system (tts ng 10 mg/24 h) 24 hours after application were evaluated by exercise left ventricular radionuclide cineangiography. 20 patients with ischemic heart disease were included in a double-blind, within patient, acute study comparing tts ng to placebo. were measured: exercise-test parameters and global (ef) and regional (ref) ejection fractions at rest and during exercise. at maximum load, the double product rose from 18,680 +/- 4,118 w ...	2011	3122628
lactate dehydrogenase and malate dehydrogenase of sertoli cells in rats.	lactate-dehydrogenase (ldh) and malate-dehydrogenase (mdh) activities and isozyme patterns of maturing sertoli cells were investigated in cultured cells obtained from 2-5-week-old rats. both enzymes, and more strikingly ldh, increased between 2 and 3 weeks of age. ldh isozyme complement included all five isozymes and, in the more mature rats, had a shift toward the isoforms rich in subunit. these data are consistent with an increasing production of lactate/pyruvate and with a finer regulation of ...	1987	3122678
interleukin-2 receptor levels are increased in blood of heart transplant patients during infections.	increased levels of soluble interleukin-2 (il-2) receptor were found in plasma of six patients after the heart transplantation. the levels peaked the first week after transplantation and then gradually decreased to normal levels. the moderate episodes of heart transplant rejection did not affect the il-2 receptor levels in comparison to transplant recipients without the rejection episodes. however, the transplant patients with pneumonia had the il-2 receptor levels ten times higher than healthy ...	2011	3123088
telomeric dna-protein interactions of oxytricha macronuclear dna.	telomeres of oxytricha macronuclear chromatin exist as discrete nonnucleosomal dna-protein complexes, each of which encompasses the terminal 100-150 bp of a macronuclear dna molecule. we have used chemical and nuclease footprinting to examine the internal structure of these telomeric complexes. remarkably salt-stable dna-protein interactions result in methylation-protection of specific guanine residues in the 3'-terminal t4g4t4g4 tail. the methylation pattern seen in vivo and in isolated macronu ...	2011	3123321
future developments in the food industry.		2011	3123680
polymicrobial septicemia due to shigella flexneri and pseudomonas aeruginosa: first report.	an invasion of the bloodstream by members of the genus shigella is extremely rare. when it does occur, the etiologic agent is usually a single organism. a report of the first case of shigella bacteremia that was complicated by pseudomonas aeruginosa sepsis is reported.	1987	3123706
clinical predictors of arrhythmia worsening by antiarrhythmic drugs.	aggravation of ventricular arrhythmia is a serious, potentially lethal, side effect that can occur with all antiarrhythmic agents. the purpose of this retrospective case-controlled study was to identify clinically useful parameters that would predict aggravation of arrhythmia. patients in whom arrhythmia worsened while taking either quinidine, mexiletine or encainide were selected and matched to 2 similar patients who never developed this drug complication with any antiarrhythmic tested. a numbe ...	2011	3124591
effects of cadmium on human platelet reactions.	human platelets incubated with cd2+ took up the cation slowly, and the uptake was speeded up by ionophore a23187. the capacity of human platelets to accumulate cd2+ was large, equivalent to 10 nmol cd2+ per mg protein. the effects of cd2+ on protein phosphorylation and serotonin release of human platelets were studied. washed platelets incubated with cd2+ showed a general increase in protein phosphorylation concurrent with a slow release of serotonin. in the presence of ionophore a23187, however ...	1987	3125819
factors influencing the accumulation of sediment-sorbed hexachlorobiphenyl by midge larvae.		2011	3125867
estimation of pyruvate dehydrogenase (e1) activity in human skeletal muscle; three cases with e1 deficiency.	pyruvate dehydrogenase (e1) catalyzes the rate-limiting step of the pyruvate dehydrogenase complex. since e1 activity of human muscle tissue is low, a sensitive method is needed for diagnostic purposes. measurement of 14co2 production from [1-14c]pyruvate provides a specific and sensitive assay for measuring e1 activity. we use as artificial electron acceptor dichlorophenolindophenol (dcpip) instead of the often applied ferricyanide. the method can be applied to small muscle samples obtained by ...	1988	3127087
preliminary report of haemoproteus tinnunculi infection in a breeding population of american kestrels (falco sparverius).	a population of american kestrels breeding in southeastern pennsylvania was examined for hematozoa. haemoproteus tinnunculi infected 17 of 23 (74%) of the adults. parasitemia ranged from two to 252, with a median of 32 infected erythrocytes per 10,000. parasitemia and body weight of female kestrels were negatively correlated. this parasite was not observed in the six juvenile or 38 nestling kestrels examined. trypanosoma sp. was detected by culture in three of seven (43%) adults, but not in the ...	2011	3127602
electron backscatter corrections for parallel-plate chambers.	the wall of an ionization chamber is commonly assumed to have a negligible effect on chamber response in electron beams. for cylindrical chambers with thin walls this assumption is valid. however, parallel-plate chambers commonly possess large mechanical supports which may affect chamber response in a manner not accounted for in current dosimetry protocols. this is due to changes with energy in the relative backscattered electron fluence between chamber support and phantom materials. to investig ...	2011	3127670
antinuclear antibody-negative systemic lupus erythematosus (sle) and severe renal involvement: close correlation between disease activity and appearance of circulating anticoagulant.	a 16-year-old girl meeting the criteria for sle is described. salient features of the clinical course included active glomerulonephritis with dense subepithelial deposits on electron microscopy, pulmonary embolism, axillary vein thrombosis, arthritis, serositis and fever. disease activity correlated with the presence of lupus anticoagulant as measured by vdrl and partial thromboplastin time (ptt). her serum was consistently negative to ana, anti-ds-dna, anti-ss-dna, ena, anti-ro, anti-la, and le ...	2007	3128493
feline aortic thromboemboli.		1988	3128904
application of a decision-making model for resolving ethical problems.		2011	3128937
induction of indoleamine dioxygenase by interferon in mice: a study with different recombinant interferons and various cytokines.	since it is important the availability of a specific marker for interferon induction in vivo, we investigated the effect of different recombinant interferons and various cytokines on indoleamine 2,3-dioxygenase activity. although with different magnitude, recombinant interferon-alpha a/d (bgl ii) hybrid, interferon-gamma and tumor necrosis factor, all increase the activity of this enzyme, whereas interleukin-1, recombinant interferon-alpha a and interferon-alpha d do not induce this activity in ...	2011	3128977
reappearance of embryonic neutral alpha-glucosidase isoenzyme in acid maltase-deficient muscle of japanese quail.	two neutral alpha-glucosidase isoenzymes were isolated from the muscle of japanese quails with late-onset acid maltase deficiency. one isoenzyme is predominantly expressed in embryonic muscle and the other in adult muscle. the time of switching from one to the other of these two neutral alpha-glucosidases was the same as in normal birds. the glycogen content in acid maltase-deficient muscle was not inversely proportional to the amount of embryonic neutral alpha-glucosidase. from the results, we ...	2011	3129300
inhibition of beta-bungarotoxin binding to brain membranes by mast cell degranulating peptide, toxin i, and ethylene glycol bis (beta-aminoethyl ether)-n,n,n',n'-tetraacetic acid.	the presynaptically active snake venom neurotoxin beta-bungarotoxin (beta-butx) is known to affect neurotransmitter release by binding to a subtype of voltage-activated k+ channels. here we show that mast cell degranulating (mcd) peptide from bee venom inhibits the binding of 125i-labeled beta-butx to chick and rat brain membranes with apparent ki values of 180 nm and 1100 nm, respectively. the mechanism of inhibition by mcd peptide is noncompetitive, as is inhibition of 125i-beta-butx binding b ...	1988	3130091
lectin-like components in the macronuclear replication bands of euplotes eurystomus.	upon incubation with fluoresceinylated neoglycoproteins, isolated macronuclei from the ciliated protozoan euplotes eurystomus display different labelling patterns depending on the nature of the sugar bound to the neoglycoproteins. specific sugar-binding components (i.e., lectin-like molecules) are associated with presumed nucleoli and with the macronuclear replication bands. this is the first demonstration that dna synthesis and sugar-binding components are co-localized in an eukaryotic cell.	2010	3130115
lectin-like components in the macronuclear replication bands of euplotes eurystomus.	upon incubation with fluoresceinylated neoglycoproteins, isolated macronuclei from the ciliated protozoan euplotes eurystomus display different labelling patterns depending on the nature of the sugar bound to the neoglycoproteins. specific sugar-binding components (i.e., lectin-like molecules) are associated with presumed nucleoli and with the macronuclear replication bands. this is the first demonstration that dna synthesis and sugar-binding components are co-localized in an eukaryotic cell.	2010	3130115
effects of growth hormone-releasing hormone and corticotropin-releasing hormone on the release of thyrotropin-releasing hormone from the rat hypothalamus in vitro.	effects of growth hormone-releasing hormone (grh) and corticotropin-releasing hormone (crh) on the release of immunoreactive thyrotropin-releasing hormone (ir-trh) from the rat hypothalamus in vitro were studied. the rat hypothalamus was incubated in medium 199 with 1.0 mg/ml of bacitracin (ph 7.4) for 20 min. the amount of ir-trh release into the medium was measured by radioimmunoassay. the ir-trh release from the rat hypothalamus was inhibited significantly in a dose-related manner with the ad ...	1987	3131150
high progesterone/estradiol ratio in follicular fluid at oocyte aspiration for in vitro fertilization as a predictor of possible pregnancy.	eighteen women undergoing in vitro fertilization (ivf) procedures were studied. all had optimal (900 to 1600 pg/ml) peak serum estradiol (e2) response to the same stimulation regimen with clomiphene citrate and menotropins; fertilization rate was above 64%; and two to four embryos in two to eight cell stages were replaced in each patient. all were considered to have optimal chances for conception. the authors compared progesterone (p), e2, and p/e2 ratio in serum and follicular fluid (ff) at the ...	2011	3131157
records involving riders of powered two-wheeled vehicles.		2011	3131520
valproate-associated hepatotoxicity and its biochemical mechanisms.	intake of the anticonvulsant drug valproic acid, or its sodium salt, has been associated with occasional instances of severe and sometimes fatal hepatotoxicity. probably at least 80 cases have occurred worldwide. the syndrome affects perhaps 1 in 10,000 persons taking the drug, and usually develops in the early weeks or months of therapy. most instances have involved children, usually those receiving more than 1 anticonvulsant. multiple cases have occurred in 2 families. the typical presentation ...	2011	3131628
[histamine liberation inhibitors].		2011	3131688
[this is how parents can feel--donna is coming home with us! wait, you can't just do that!].		2011	3131909
death despite malaria prophylaxis.		1988	3133035
departmental divisions and the crisis in undergraduate medical education.		2011	3133048
esophageal leiomyoma arising in an epiphrenic diverticulum.	a 32-year old woman was found at surgery to have an esophageal leiomyoma arising within an epiphrenic diverticulum. these uncommon conditions may rarely occur together, causing difficulty in diagnosis of the leiomyoma. other neoplasms may also arise in an epiphrenic diverticulum and should be borne in mind in this situation.	2011	3133209
industry weighs merits of long-term care bills.		2011	3133303
[progress in health services research. diagnostic related groups].		2011	3133820
peliosis hepatis in a patient with marasmus.	peliosis hepatitis is a rare disorder previously seen in tuberculosis and malignant disorders and now seen with anabolic steroid use or after renal transplantation. we report the first case of peliosis hepatis in a patient with marasmus and no previously reported predisposing condition. of interest, the peliosis hepatis resolved rapidly (over 2-3 wk) as determined by computed tomography scan and the patient presented with a cholestatic enzyme pattern that resolved with development of the lesion.	2011	3135227
segregation analysis of juvenile myoclonic epilepsy.	we examined the inheritance of juvenile myoclonic epilepsy (jme). we looked at both the trait of "epilepsy" and the trait of "epilepsy-plus-eeg abnormalities," since eeg abnormalities are frequently found in the clinically unaffected sibs of jme patients. we tested several modes of inheritance including the fully penetrant recessive and several two-locus models. we could reject all models tested (fully penetrant single-locus and two-locus models) when abnormal eegs were classified as "unaffected ...	2010	3136050
the unique nutritional needs of the elderly patient with cancer.		2011	3136525
hcfa will test a new hmo payment system.		2010	3137146
processing of neurofilament proteins from perikaryal to axonal type.	in previous studies, neuronal cell bodies, excised by hand from bovine spinal ganglia, were analyzed and heterogeneous intermediate and high molecular weight neurofilament proteins that differed in electrophoretic mobility from their axonal counterparts were demonstrated. in the present experiment, intermediate and high molecular weight neurofilament proteins of the axonal type were treated with alkaline phosphatase, and neurofilament proteins enriched in perikaryal type proteins were labeled wi ...	1988	3137483
monitoring during sedation for endoscopy.		2011	3139209
[dysenteric arthritis--a case-related observation].		1988	3140351
asnr presidential address, 1988.		2011	3140646
expression of four virulence antigens of shigella flexneri is positively regulated at the transcriptional level by the 30 kilodalton virf protein.	on the virulence plasmid of shigella flexneri the virg region required for cell-to-cell spread of the bacterium encodes a 130 kilodalton (kd) antigen and region-2 essential for the bacterial invasion of epithelial cells encodes 57, 43 and 39 kd antigens. the expression of these four antigens is positively regulated by the 30 kd protein encoded by virf, whose nucleotide sequence had been determined and which was previously found to be essential for virulence. an approximately 3.8 kilobase (kb) rn ...	1988	3141742
alcohol-related birth defects: an update.	historically, mankind has at least suspected that alcohol was somehow connected with undesirable effects on progeny. in the 18th century, physicians became aware that maternal alcohol consumption resulted in excess fetal and neonatal mortality, low birth weight, and many other deleterious effects. perhaps as a response to the temperance and prohibition periods, scientists lost sight of or interest in the effects of alcohol in pregnancy. in the late 1960s and early 1970s, the issue surfaced again ...	2011	3141958
[structural and ultrastructural study of the kidney of the tench, tinca tinca l., after experimental poisoning by the absorption of lead nitrate].		2011	3142178
guidelines for the use of vitamins, trace elements, calcium, magnesium, and phosphorus in infants and children receiving total parenteral nutrition: report of the subcommittee on pediatric parenteral nutrient requirements from the committee on clinical practice issues of the american society for clinical nutrition.		2011	3142247
altered images.		2011	3143092
problems assessed but far from resolved in 1988.		2011	3143657
arterialisation of transcutaneous oxygen and carbon dioxide.	we compared previously calculated global correction factors for oxygen and carbon dioxide arterial/transcutaneous ratios with individual in vivo calibrations from the first arterial sample. in infants beyond the neonatal period and older children in vivo calibration confers little benefit over the use of a global calibration correction factor for transcutaneous carbon dioxide, and may reduce the precision with which arterial oxygen can be estimated from transcutaneous oxygen.	2011	3144247
controversy over mammographic screening.		2011	3145061
[dynamic characteristics of seizures with psychopathologic manifestations in patients with true epilepsy].		2011	3145644
[artificial nutrition and alcoholic cirrhosis].	malnutrition is observed in 60 p. cent of patients with alcoholic cirrhosis. it is characterized by weight loss, hypoproteinemia, and a negative nitrogen balance. it is due to multiple causes. this malnutrition increases the risk of disturbances in the immune system, susceptibility to infection, and postoperative complications. re-nutrition by standard methods of feeding often is inadequate or impractical. use of artificial nutrition is often made necessary either by enteral or parenteral route. ...	2011	3145703
short- and long-term effects of a single dose of bisphosphonates on retinoid-induced bone resorption in thyroparathyroidectomized rats.	the inhibitory effect of a single subcutaneous (s.c.) dose of three different bisphosphonates (bps)--4-amino-1-hydroxybutylidene-1,1-bisphosphonate (ahbubp), 2-(2-pyridinyl)-ethylidene-1,1-bisphosphonate (2-pebp), and dichloromethylene-bisphosphonate (cl2mbp)--was studied in a model of retinoid-induced bone resorption, which consists of assessing the hypercalcemic effect of the arotinoid ro 13-6298 given s.c. for three days in thyroparathyroidectomized (tptx) rats. the retinoid was given on day ...	1988	3145796
plasmid dna survey of clinically isolated shigella strains in shanghai area.		1988	3145835
coagulation, inflammation, and responses to injury.	several mechanisms contributing to the development of post-traumatic alterations in organ function are reviewed. the importance of interactions between clotting and inflammatory mediators is detailed. a discussion of management strategies emphasizes the role of early recognition and aggressive treatment of organ dysfunction.	2011	3146417
effects of maternal exposure to polychlorobiphenyls (pcbs) on f1 generation behavior in the rat.	the effect of fenclor 42 (pcb) exposure of female rats (fischer 344 strain) was studied through assessment of the behavioral development of their f1 progeny. female rats were exposed to pcb according to the following treatment schedule: (a) (5 days) 2 weeks prior to mating, (b) during gestation (days 6-15 of pregnancy), (c) during lactation (days 1-21 after delivery). behavioral endpoints of motor reflexes, motor coordination, activity (preweaning behaviors), and learning (postweaning behavior) ...	1988	3146520
scopolamine produces environment-specific conditioned activity that is not blocked by pimozide in rats.	a classical conditioning paradigm was employed to determine if the stimulant effects of the anticholinergic scopolamine could show conditioning. in experiment 1 rats had 12 60-min pairings of scopolamine (1.0 or 8.0 mg/kg, ip) with a distinctive environment that monitored horizontal and vertical activity. experimental (paired) groups received the drug 30 min prior to each session, whereas control (unpaired) groups received saline. following each session the paired groups were injected with salin ...	1988	3146771
effects of interferon alpha on performance in man: a preliminary report.	the effects of three doses of interferon alpha (1.5 mu, 0.5 mu and 0.1 mu) on performance were studied. the injection of 1.5 mu ifn produced symptoms and performance changes which closely resembled those found in volunteers with influenza. specifically, volunteers were slower at responding when they were uncertain when a target stimulus would appear, but were not impaired on a pursuit tracking task or syntactic reasoning task. the results suggest that interferon-induced changes in cns function p ...	1988	3146777
[the effect of long-term exposure to gamma rays (6,7 gy) on the activity of monoamine oxidase in the hypothalamus of sheep during the anestrus period].		1988	3146833
the influence of duration of photoperiod and hemicastration on growth and testicular and endocrine functions of boars.	yorkshire boars were used to evaluate the influence of duration of photoperiod and hemicastration on growth and testicular and endocrine functions. at 10 wk of age, 5 hemicastrate (hc) and 5 intact (i) boars were assigned to either 8 or 16 hr of light daily until 6 mo of age. body weights were recorded biweekly throughout the experiment. venous cannulae were placed in all boars at 6 mo of age, and serum was collected at 30 min intervals from 0800 to 2000 hr. gonadotropin releasing hormone (gnrh) ...	1988	3147165
[antiphospholipid antibody syndrome].		2011	3147518
carbonic anhydrase isoenzymes in the caecum and colon of normal and germ-free rats.	histochemical and immunocytochemical methods were used to study the presence of carbonic anhydrase (ca) isoenzymes in the caecum and colon of normal and germ-free rats. very high enzyme activity was demonstrated by histochemistry in the caecum and proximal colon of normal rats, while the activity decreased in the distal colon. very strong immunostaining for the isoenzyme ca i was found in the cytoplasm of surface cells and upper gland cells in the caecum and colon of normal rats. in the distal c ...	1988	3147569
in vivo measurement of intracellular ph in human brain during different tensions of carbon dioxide in arterial blood. a 31p-nmr study.	the effect of changes in carbon dioxide tension in arterial blood upon intracellular ph in brain tissue was studied in seven healthy volunteers, aged 22-45 years. the ph changes were monitored by use of 31p nuclear magnetic resonance spectroscopy, performed on a whole-body 1.5 tesla siemens imaging system. the measurements were carried out during hyperventilation and with the subject breathing atmospheric air containing 5 vol. % and 7 vol. % carbon dioxide. intracellular ph increased significant ...	1988	3147578
the development of immunological relationship between mother and fetus under physiological and pathological conditions.	on the basis of results of our research and review of literature, the complex of immuno logical influences, operating during the development of the human fetus, were evaluated. it is obvious that during the early stages of pregnancy the conceptus is protected by non-specific mechanisms, i.e. hormonally (hcg, progesterone) and by certain properties of the trophoblast (barrier function, immunologically inert surface). specific immunological tolerance is formed by gradual penetration of trophoblast ...	1988	3147589
comparison of the invasion strategies used by salmonella cholerae-suis, shigella flexneri and yersinia enterocolitica to enter cultured animal cells: endosome acidification is not required for bacterial invasion or intracellular replication.	strains of escherichia, salmonella, shigella and yersinia actively enter eukaryotic cells. several techniques were used to compare and contrast the invasion mechanisms of salmonella cholerae-suis, yersinia enterocolitica and shigella flexneri. three animal cell lines (cho, hep-2 and mdck) were examined for susceptibility to bacterial entry by these strains. levels of intracellular bacteria varied widely between cell lines, but cho cells were the most susceptible to bacterial invasion, hep-2 inva ...	1988	3147700
using computers to take patient histories.		2011	3147730
focal spike discharges in children not suffering from clinical epilepsy.		2011	3149369
[lysosomal enzyme activity in the nerve tissue of various species of animals after administration of a neurotoxic pesticide aphos].		1988	3149613
pattern reversal visual evoked potentials in phenylketonuria.	the pathogenesis of brain dysfunction in phenylketonuria (pku) is still under investigation. hyperphenylalaninaemia results in increased turnover of myelin. in order to demonstrate the derangement of myelinization in pku we studied the visual evoked potentials (vep) in 14 pku patients and in 20 normal subjects. vep findings were correlated with the metabolic control of the disease and with the electroencephalographic findings. vep were more sensitive than the eeg in detecting a neurological dysf ...	2011	3149700
production of prostaglandins and hete-compounds by isolated-cultivated bovine aortic endothelial cells.	the main product of aa conversion by baec is pgi2. other pgs were synthesized by confluent cells only in traces with exception of a hht-like compound which has still to be characterized in more details. a significant release of hete was only detected when baec were destroyed. under these conditions about 1 pmole/10(5) cells 15- and 12 hete were released by baec. taken into account the amounts of hete produced by endothelial cells as well as the partially contradictory activities of 12- and 15-he ...	1988	3150276
the use of imipramine in minor motor seizures.	a study is presented of 15 pediatric patients treated with imipramine for uncontrolled seizures during the past two years. of these patients, 53% had an initial reduction of seizures of greater than 80%. at one year, 26% were still seizure-free. drop attacks were especially responsive to therapy; 100% (7/7) responded initially to imipramine therapy. most patients studied had been receiving valproate and another major antiepileptic drug prior to imipramine therapy. this study confirms previous re ...	2011	3150277
anti-cancer therapy with valine-depleted amino acid imbalance solution.	for the purpose of developing amino acid imbalance solution applicable to cancer treatment, we prepared seven kinds of amino acid imbalance solutions based on a 10% balanced amino acid solution and investigated the anti-tumor effects of each solution. the administration of valine-depleted amino acid solution for 8 days at a daily dose of 53 ml/rat (79.5 kcal/rat) resulted in the most significant inhibitory effects on the growth of hepatoma (ah109a) and mammary tumors (mrmt-1), the rate being 82. ...	1988	3150873
the treatment of glomerulonephritis in children.	the results of treatment of glomerulonephritis (gn) in childhood with oral corticosteroids, immunosuppressive drugs, anticoagulants and the newer regimens of pulsed, high-dose intravenous methylprednisolone and plasma exchange are reviewed and compared with the natural history of the untreated condition. poststreptococcal gn and the nephritis of schönlein-henoch purpura need no specific treatment unless extensive glomerular crescents are present. the progression of mesangiocapillary gn can proba ...	2011	3153019
urinary infection and staghorn calculus in the left kidney.		1988	3153046
vitamin d metabolite profiles in moderate renal insufficiency of childhood.	in a prior study, we reported vitamin d metabolite profiles in the plasma of healthy children. in view of these findings, we investigated these same profiles in children with moderate renal insufficiency. specimens were obtained in both summer and winter in untreated patients, and before and after treatment for up to 1 year, with either 25(oh)d3 or 1,25(oh)2d3. mean pretreatment 1,25(oh)2d levels were normal. levels of 25(oh)d3 were also normal and continued to vary with season. mean pretreatmen ...	2011	3153059
acute circulatory effects of doxorubicin in the conscious dog.	experimental work on the mechanisms of acute doxorubicin-induced cardiotoxicity may contribute to a better understanding of the clinical problem of cardiac failure after treatment with anthracycline derivatives. we studied aortic pressure and heart rate continuously for 1 h following a bolus injection of doxorubicin (1 mg/kg) in 7 dogs. in contrast with previous studies in intact animals, no anesthesia was used in order to eliminate possible interactions of doxorubicin with other drugs. one minu ...	1986	3153244
shiga toxin.		1986	3153582
[usefulness of the diagnosis of grade iii placenta using ultrasonography in the management of prolonged pregnancy].		2011	3154276
subconjunctival orbital fat prolapse.	subconjunctival orbital fat prolapse is a benign entity in which fat herniates through tenon's capsule. it is often confused with other lesions such as lacrimal gland tumors, lymphoid tumors and lipodermoids. the clinical and computed tomographic findings in a series of 15 patients are presented, and the features that are helpful in the differential diagnosis are discussed.	2011	3154584