Publications
| Title | Abstract | Year Filter | PMID(sorted ascending) Filter |
|---|
| emphysematous vaginitis. | emphysematous vaginitis is a rare condition, characterized by the presence of multiple gas-filled cysts in the vaginal and/or exocervical mucosa. although its etiology is not completely understood, it is self-limited, with a benign clinical course. vaginal discharge, sometimes bloody, and pruritus are the most common symptoms. chronic and acute inflammation can be found, and diseases that impair the immune system and pregnancy have been associated with this condition. | 2015 | 25551590 |
| improved antiparasitic activity by incorporation of organosilane entities into half-sandwich ruthenium(ii) and rhodium(iii) thiosemicarbazone complexes. | a series of ferrocenyl- and aryl-functionalised organosilane thiosemicarbazone compounds was obtained via a nucleophilic substitution reaction with an amine-terminated organosilane. the thiosemicarbazone (tsc) ligands were further reacted with either a ruthenium dimer [(η(6-i)prc6h4me)ru(μ-cl)cl]2 or a rhodium dimer [(cp*)rh(μ-cl)cl]2 to yield a series of cationic mono- and binuclear complexes. the thiosemicarbazone ligands, as well as their metal complexes, were characterised using nmr and ir s ... | 2015 | 25559246 |
| genome mining offers a new starting point for parasitology research. | parasites including helminthes, protozoa, and medical arthropod vectors are a major cause of global infectious diseases, affecting one-sixth of the world's population, which are responsible for enormous levels of morbidity and mortality important and remain impediments to economic development especially in tropical countries. prevalent drug resistance, lack of highly effective and practical vaccines, as well as specific and sensitive diagnostic markers are proving to be challenging problems in p ... | 2015 | 25563615 |
| epidemiology and laboratory characteristics of trichomonas vaginalis infection in croatian men with and without urethritis syndrome: a case-control study. | the main objective of this study is to determine the prevalence of trichomoniasis in men with and without symptoms of urethritis, with concomitant analysis of sociodemographic and behavioural specificities of both groups. also, the objective is to evaluate laboratory methods used in the diagnostics of this parasitic disease. | 2015 | 25568091 |
| clinical characteristics of aerobic vaginitis and its association to vaginal candidiasis, trichomonas vaginitis and bacterial vaginosis. | examine clinical characteristics of aerobic vaginitis and mixed infection for the purpose of better diagnostic accuracy and treatment efficiency. | 2013 | 25568514 |
| the secretory products of trichomonas vaginalis decrease fertilizing capacity of mice sperm in vitro. | trichomonas vaginalis infection is one of the most prevalent sexually transmitted infections in humans and is now recognized as an important cause of infertility in men. there is little information about the effect of extracellular polymeric substances (eps) from t. vaginalis on sperm, but previous reports do not provide a conclusive description of the functional integrity of the sperm. to investigate the impact of eps on the fertilizing capacity of sperm, we assessed sperm motility, acrosomal s ... | 2016 | 25578937 |
| etiology and antimicrobial susceptibility of pathogens responsible for urethral discharge among men in harare, zimbabwe. | periodic etiological surveillance of sexually transmitted infection (sti) syndromes is required to validate treatment algorithms used to control stis. however, such surveys have not been performed in zimbabwe over the past decade. | 2014 | 25581806 |
| the antimicrobial effect of boric acid on trichomonas vaginalis. | the treatment options for trichomoniasis are largely limited to nitroimidazole compounds (metronidazole and tinidazole). few alternatives exist in cases of recalcitrant infections or in cases of nitroimidazole hypersensitivity. recently, the intravaginal administration of boric acid has been advocated as an alternative treatment of trichomoniasis. however, no in vitro studies are available that directly assess the sensitivity of trichomonas vaginalis to boric acid. | 2014 | 25581807 |
| dithiocarbamate-thiourea hybrids useful as vaginal microbicides also show reverse transcriptase inhibition: design, synthesis, docking and pharmacokinetic studies. | prophylactic prevention is considered as the most promising strategy to tackle sti/hiv. twenty-five dithiocarbamate-thiourea hybrids (14-38) were synthesized as woman controlled topical vaginal microbicides to counter trichomonas vaginalis and sperm along with rt inhibition potential. the four promising compounds (18, 26, 28 and 33) were tested for safety through cytotoxic assay against human cervical cell line (hela) and compatibility with vaginal flora, lactobacillus. docking study of most pro ... | 2015 | 25592712 |
| a multiplex pcr assay for the simultaneous detection of chlamydia trachomatis, neisseria gonorrhoeae, and trichomonas vaginalis. | for developing countries, sexually transmitted infections (stis) and their complications are ranked in the top 5 disease categories for which adults seek medical treatment. chlamydia trachomatis (ct), neisseria gonorrhoeae (ng), and trichomonas vaginalis (tv) are the three most common stis worldwide, with tv accounting for over half of the cases. in developing countries, traditional methods for diagnosing stis are laborious, often not very sensitive, and have a long turnaround time with most rec ... | 2015 | 25595915 |
| sexually transmitted infections, benign prostatic hyperplasia and lower urinary tract symptom-related outcomes: results from the prostate, lung, colorectal and ovarian cancer screening trial. | to examine whether a history of sexually transmitted infections (stis) or positive sti serology is associated with prevalent and incident benign prostatic hyperplasia (bph)/lower urinary tract symptoms (luts)-related outcomes in the prostate, lung, colorectal and ovarian cancer screening trial. | 2015 | 25601300 |
| trichomonas vaginalis infection induces vaginal cd4+ t-cell infiltration in a mouse model: a vaccine strategy to reduce vaginal infection and hiv transmission. | complications related to the diagnosis and treatment of trichomonas vaginalis infection, as well as the association between t. vaginalis infection and increased transmission of and susceptibility to human immunodeficiency virus, highlight the need for alternative interventions. we tested a human-safe, aluminum hydroxide-adjuvanted whole-cell t. vaginalis vaccine for efficacy in a balb/c mouse model of vaginal infection. | 2015 | 25616405 |
| protocols for the routine screening of drug sensitivity in the human parasite trichomonas vaginalis. | trichomonas vaginalis is a sexually transmitted protozoan parasite of humans. treatment of trichomoniasis is almost completely dependent on the old drug metronidazole and is hampered by resistance. new drug development, like routine screening for drug resistance, has however been hampered by the lack of reliable screening protocols with sufficient throughput. here we report on two separate in vitro protocols that use fluorescent dyes and allow for standardized drug sensitivity testing on the req ... | 2015 | 25618339 |
| direct diagnosis of trichomonas vaginalis infection on archived pap smears using nested pcr. | little information is available concerning pcr-based direct detection of trichomonas infections on archived pap (papanicolaou)-stained smears. this study investigates dna extraction and amplification from archived pap smears. trichomonas vaginalis is a parasitic protozoan that infects the urogenital tract of women. | 2015 | 25633887 |
| a mixed methods approach to assess the likelihood of testing for sti using self-collected samples among behaviourally bisexual women. | behaviourally bisexual women (women who have sex with women and men (wswm)) are more likely to report a history of sexually transmitted infections (sti) than women who have sex exclusively with men or exclusively with women. barriers to care may prohibit wswm from seeking sti testing. the present study investigated participant willingness to self-collect oral, vaginal and anal samples for sti testing. | 2015 | 25637328 |
| evaluation of different staining techniques in the diagnosis of trichomonas vaginalis infection in females of reproductive age group. | trichomonas vaginalis is a parasitic protozoan which causes most common non viral sexually transmitted disease trichomoniasis. direct microscopic examination of vaginal fluid remains the most widely used diagnostic test. although, wet mount examination is the most cost-effective diagnostic test, but it has low sensitivity resulting in under diagnosis of the disease. therefore, to overcome this problem, various staining techniques like giemsa and acridine orange can be used along with wet mount e ... | 2014 | 25653944 |
| prevalence of 3 sexually transmitted infections in a pediatric emergency department. | this study aimed to determine the prevalence of chlamydia trachomatis, neisseria gonorrheae, and trichomonas vaginalis and to describe factors associated with sexually transmitted infection (sti) in a pediatric emergency department (ed). | 2015 | 25654676 |
| trichomonas vaginalis infection: how significant is it in men presenting with recurrent or persistent symptoms of urethritis? | persistent or recurrent non-gonococcal urethritis has been reported to affect up to 10-20% of men attending sexual health clinics. an audit was undertaken to review the management of persistent or recurrent non-gonococcal urethritis in men presenting at whittall street clinic, birmingham, uk. detection of trichomonas vaginalis infection was with the newly-introduced nucleic acid amplification test. a total of 43 (8%) of 533 men treated for urethritis re-attended within three months with persiste ... | 2016 | 25663246 |
| comparison of four diagnostic techniques for detection of trichomonas vaginalis infection in females attending tertiary care hospital of north india. | trichomonas vaginalis causes a common sexually transmitted disease trichomoniasis, which may lead to increased risk of transmission of human immunodeficiency virus infection and other pelvic inflammatory diseases. wet mount examination is the most common test for diagnosis, but it has low sensitivity. acridine orange staining can be used for diagnosis, but it requires special microscopic facility. culture is considered as the gold standard, but it takes a long time for diagnosis. osom trichomona ... | 2015 | 25673589 |
| the biology of trichomonas vaginalis in the light of urogenital tract infection. | the human pathogen trichomonas vaginalis is a parasitic protist. it is a representative of the eukaryotic supergroup excavata that includes a few other protist parasites such as leishmania, trypanosoma and giardia. t. vaginalis is the agent of trichomoniasis and in the us alone, one in 30 women tests positive for this parasite. the disease is easily treated with metronidazole in most cases, but resistant strains are on the rise. the biology of trichomonas is remarkable: it includes for example t ... | 2014 | 25677793 |
| genetic identification of trichomonas vaginalis by using the actin gene and molecular based methods. | trichomonas vaginalis is the agent of urogenital tract infection that causes human trichomoniasis with some serious health complications. more understanding about genetic features of the parasite can be helpful in the study of the pathogenesis, drug susceptibility and epidemiology of the infection. for this end, we conducted analysis of the actin gene of t. vaginalis by applying the pcr-sscp (pcr-single stranded conformational polymorphism) and nucleotide sequencing method. | 2014 | 25678916 |
| pentamycin shows high efficacy against trichomonas vaginalis. | trichomonas vaginalis is the causative agent of the venereal disease trichomoniasis, which is the most frequent non-viral sexually transmitted disease worldwide. since the 1960s, metronidazole has been the standard treatment, however an increasing number of cases with metronidazole-resistant strains is being reported. in this study, pentamycin, a polyene antibiotic, was tested for its in vitro efficacy against t. vaginalis using four strains with different metronidazole susceptibilities. it was ... | 2015 | 25703311 |
| the c-terminal tail of tetraspanin proteins regulates their intracellular distribution in the parasite trichomonas vaginalis. | the parasite trichomonas vaginalis is the causative agent of trichomoniasis, a prevalent sexually transmitted infection. here, we report the cellular analysis of t.vaginalis tetraspanin family (tvtsps). this family of membrane proteins has been implicated in cell adhesion, migration and proliferation in vertebrates. we found that the expression of several members of the family is up-regulated upon contact with vaginal ectocervical cells. we demonstrate that most tvtsps are localized on the surfa ... | 2015 | 25703821 |
| prevalence of sexually transmitted infections including hiv in street-connected adolescents in western kenya. | the objectives of this study were to characterise the sexual health of street-connected adolescents in eldoret, kenya, analyse gender disparity of risks, estimate the prevalence of sexually transmitted infections (stis), and identify factors associated with stis. | 2015 | 25714102 |
| opportunities and pitfalls of molecular testing for detecting sexually transmitted pathogens. | in the last 20 years, nucleic acid amplification tests (naats) have gradually replaced traditional methods for the detection of sexually transmitted infections. naat technology comes with some considerable benefits for diagnosis, including increased sensitivity, rapid result turnaround and suitability for high throughput screening of asymptomatic individuals using more-readily available specimens. however, the transition to naat has not come without its problems. false-negative and false-positiv ... | 2015 | 25714587 |
| trichomonas vaginalis infection among iranian general population of women: a systematic review and meta-analysis. | trichomonas vaginalis (t. vaginalis) is one of the main causes of vaginitis, prostatitis, and cervicitis all over the world. little information is available regarding the burden of t. vaginalis infection in iranian women. this systematic review and meta-analysis were carried out to determine the prevalence of t. vaginalis among general population of iranian women. data were systematically collected from 1992 to 2012 in iran on such electronic databases as pubmed, google scholar, science direct, ... | 2015 | 25732256 |
| multipurpose prevention technologies: the future of hiv and sti protection. | every day, more than 1 million people are newly infected with sexually transmitted infections (stis) that can lead to morbidity, mortality, and an increased risk of human immunodeficiency virus (hiv) acquisition. existing prevention and management strategies, including behavior change, condom promotion, and therapy have not reduced the global incidence and prevalence, pointing to the need for novel innovative strategies. this review summarizes important issues raised during a satellite session a ... | 2015 | 25759332 |
| trichomoniasis: a brief review of diagnostic methods and our experience with real-time pcr for detecting infection. | trichomoniasis is the most common non-viral sexually transmitted infection, and it is caused by the protozoan flagellate trichomonas vaginalis. although highly prevalent in sexually active women, it has long been overlooked in other groups of potentially infected people. recently, studies have shown that trichomoniasis increases the risk of infection with human immunodeficiency virus and can cause adverse outcomes of pregnancy, which has increased interest in t. vaginalis and increased the need ... | 2015 | 25770306 |
| synthesis and in vitro and in vivo biological evaluation of substituted nitroquinoxalin-2-ones and 2,3-diones as novel trichomonacidal agents. | two series of ten novel 7-nitroquinoxalin-2-ones and ten 6-nitroquinoxaline-2,3-diones with diverse substituents at positions 1 and 4 were synthesized and evaluated against the sexually transmitted parasite trichomonas vaginalis. furthermore, diverse molecular and drug-likeness properties were analyzed to predict the oral bioavailability following the lipinski's "rule of five". 7-nitroquinoxalin-2-one derivatives displayed moderate to high in vitro activity while the efficiency of most nitroquin ... | 2015 | 25771033 |
| trichomonas vaginalis associated with chronic penile ulcers and multiple urethral fistulas. | the case of a 29-year-old, hiv-infected man presenting with trichomonas vaginalis (tv)-associated chronic penile ulcers and multiple urethral fistulas is described. to our knowledge, this is the first description of chronic tv infection being implicated as the probable cause of a destructive lesion leading to sinus drainage and fistula formation. | 2015 | 25778505 |
| prevalence of trichomonas vaginalis infection among egyptian women using culture and latex agglutination: cross-sectional study. | this is a cross-sectional study carried out in the obstetrics and gynecology department at kasr al- ainy cairo university hospitals. | 2015 | 25783642 |
| natural and synthetic compound anti-trichomonas vaginalis: an update review. | trichomonas vaginalis is a flagellate protozoan that causes trichomonosis, a sexually transmitted disease of worldwide importance. however, the infection has long received much less attention than other parasitic and sexually transmitted diseases. this negligence leads to poor diagnosis and underestimated prevalence values, and consequently, it has been associated to increasing acquisition and transmission of hiv, pregnancy outcomes, infertility, pelvic inflammatory disease, and cervical and pro ... | 2015 | 25786392 |
| synthesis of nitro(benzo)thiazole acetamides and in vitro antiprotozoal effect against amitochondriate parasites giardia intestinalis and trichomonas vaginalis. | we synthesized four 5-nitrothiazole (1-4) and four 6-nitrobenzothiazole acetamides (5-8) using an easy two step synthetic route. all compounds were tested in vitro against amitochondriate parasites giardia intestinalis and trichomonas vaginalis, showing excellent antiprotozoal effects. ic₅₀'s of the most potent compounds range from nanomolar to low micromolar order, being more active than their drugs of choice. compound 1 (ic₅₀=122 nm), was 44-times more active than metronidazole, and 10-fold mo ... | 2015 | 25801157 |
| the efficacy of 2-nitrovinylfuran derivatives against leishmania in vitro and in vivo. | despite recent advances in the treatment of some forms of leishmaniasis, the available drugs are still far from ideal due to inefficacy, parasite resistance, toxicity and cost. the wide-spectrum antimicrobial activity of 2-nitrovinylfuran compounds has been described, as has their activity against trichomonas vaginalis and other protozoa. thus, the aim of this study was to test the antileishmanial activities of six 2-nitrovinylfurans in vitro and in a murine model of leishmaniasis. minimum paras ... | 2015 | 25807467 |
| effect of recombinant prophenin 2 on the integrity and viability of trichomonas vaginalis. | trichomonas vaginalis is the causal agent of trichomoniasis, which is associated with preterm child delivery, low birth weight, and an increased risk of infection by human papilloma virus and human immunodeficiency virus following exposure. several reports have established increasing numbers of trichomoniasis cases resistant to metronidazole, the agent used for treatment, and it is therefore important to identify new therapeutic alternatives. previously, our group reported the effect of tritrpti ... | 2015 | 25815316 |
| management of recalcitrant trichomonas vaginalis in pregnancy: a case report. | a case report of a pregnant woman with recalcitrant trichomonas vaginalis is described. this case was managed with suppressive treatment with metronidazole during pregnancy and cleared with paromomycin vaginal treatment after delivery. | 2016 | 25829518 |
| is trichomonas tenax a parasite or a commensal? | trichomonas tenax is considered a commensal organism found under poor oral hygiene conditions. t. tenax presents morphological similarities with t. vaginalis, and there are doubts concerning whether this protist is a parasite and whether it is a genetic variant of t. vaginalis. this study aimed to investigate the capacity of t. tenax to cause mammalian cell damage and compare its cytotoxicity with that of t. vaginalis. protozoan-host cell interaction assays were performed with madin-darby canine ... | 2015 | 25835639 |
| prevalence and factors associated with sexually transmitted infections among hiv positive women opting for intrauterine contraception. | women living with hiv/aids (wlha) are a high risk group for sexually transmitted infections (stis). however, the majority of women with stis are asymptomatic. data on prevalence of stis among wlha in uganda are limited. the objective of the study was to determine prevalence and factors associated with stis among wlha opting for intrauterine contraceptive device (iud). | 2015 | 25859659 |
| prevalence of mycoplasma genitalium and mycoplasma hominis in urogenital tract of brazilian women. | the role of mycoplasma hominis and m. genitalium in urogenital tract infections remains unknown. furthermore these mollicutes present a complex relationship with the host immune response. the role of inflammatory cytokines in infections also makes them good candidates to investigate bacterial vaginosis and mycoplasma genital infections. therefore, the aim of this study was to detect the above-mentioned mollicutes by quantitative polymerase chain reaction (qpcr) methodologies in vaginal swabs and ... | 2015 | 25886914 |
| kinetics of circulating antibody response to trichomonas vaginalis: clinical and diagnostic implications. | persistence of antibodies against pathogens after antimicrobial treatment is a marker of therapy failure or evolution to a chronic infection. the kinetics of antibody production decrease following antigen elimination is highly variable, and predicting the duration of soluble immunity in infectious diseases is often impossible. this hampers the development and use of immunoassays for diagnostic and seroepidemiological purposes. in the case of trichomonas vaginalis infection, the kinetics of antib ... | 2015 | 25887282 |
| p transposable elements in drosophila and other eukaryotic organisms. | p transposable elements were discovered in drosophila as the causative agents of a syndrome of genetic traits called hybrid dysgenesis. hybrid dysgenesis exhibits a unique pattern of maternal inheritance linked to the germline-specific small rna piwi-interacting (pirna) pathway. the use of p transposable elements as vectors for gene transfer and as genetic tools revolutionized the field of drosophila molecular genetics. p element transposons have served as a useful model to investigate mechanism ... | 2015 | 25893144 |
| papanicolaou smear findings in solid-organ transplant recipients compared with normal subjects according to the bethesda 2001 system. | solid-organ transplant recipients are at increased risk of developing cancer including cervical cancer compared with woman in the general population, mostly due to long-term immunosuppressive therapy. the papanicolaou smear remains the primary method of screening cervical pathology including preinvasive and invasive lesions. the objective of this study was to evaluate pap smear findings in solid-organ transplant recipients, determine the prevalence of abnormal smears, and compare these patients ... | 2015 | 25894158 |
| a sexually transmitted infection screening algorithm based on semiparametric regression models. | sexually transmitted infections (stis) with chlamydia trachomatis, neisseria gonorrhoeae, and trichomonas vaginalis are among the most common infectious diseases in the united states, disproportionately affecting young women. because a significant portion of the infections present no symptoms, infection control relies primarily on disease screening. however, universal sti screening in a large population can be expensive. in this paper, we propose a semiparametric model-based screening algorithm. ... | 2015 | 25900920 |
| the pathogenesis of human cervical epithelium cells induced by interacting with trichomonas vaginalis. | trichomonas vaginalis is a protozoan parasite that occurs in the urogenital-vaginal tract and is the primary causative agent of trichomoniasis, a common sexually transmitted disease in humans. the aggregation of this protozoan tends to destroy epithelial cells and induce pathogenesis. | 2015 | 25901354 |
| antenatal lower genital tract infection screening and treatment programs for preventing preterm delivery. | genital tract infection is associated with preterm birth (before 37 weeks' gestation). screening for infections during pregnancy may therefore reduce the numbers of babies being born prematurely. however, screening for infections may have some adverse effects, such as increased antibiotic drug resistance and increased cost of treatment. | 2015 | 25922860 |
| epidemiology and treatment of trichomoniasis. | trichomonas vaginalis is the most common nonviral sexually transmitted infection (sti) in the world. it was once thought to be a nuisance sti, but it is now being recognized as an important source of reproductive morbidity and a facilitator of hiv transmission and acquisition, and thus it is an important public health problem. the prevalence of t. vaginalis varies greatly by geography and risk group, but is more common among persons of african descent and appears to increase with age, though thi ... | 2015 | 25925796 |
| female reproductive hormones and biomarkers of oxidative stress in genital chlamydia infection in tubal factor infertility. | genital chlamydia infection (gci) and the associated pathologies have been implicated in tubal infertility. though the actual pathologic mechanisms are still uncertain, oxidative stress and other factors have been implicated. the purpose of the study was to determine the possible contribution of female reproductive hormones and biomarkers of oxidative stress in genital chlamydial infection to tubal occlusion. | 2015 | 25927024 |
| comparison of substance use typologies as predictors of sexual risk outcomes in african american adolescent females. | african american female adolescents have a disproportionate risk of sexually transmitted infections (stis) and other adverse sexual health outcomes. both alcohol and marijuana use have been shown to predict sexual risk among young african american women. however, no studies have attempted to differentiate alcohol and marijuana typologies use as predictors of sexual risk outcomes exclusively among adolescents who use these substances. this study compared recent alcohol and/or marijuana use as pre ... | 2016 | 25929200 |
| detection of mycoplasma genitalium from male primary urine specimens: an epidemiologic dichotomy with trichomonas vaginalis. | a total of 2750 male urines subjected to a transcription-mediated amplification (tma)-based mycoplasma genitalium assay yielded 188 positive results (6.84%). this rate was similar to chlamydia trachomatis (6.87%; p = 0.96) and greater than neisseria gonorrhoeae (4.0%) and trichomonas vaginalis (2.3%; p < 0.0002). mean age of m. genitalium-infected males (30.8) was similar to n. gonorrhoeae (p = 0.78) but less than t. vaginalis (mean, 41.6; p < 0.0001). a total of 266 sti clinic encounters had at ... | 2015 | 25934156 |
| the efficacy of 2-nitrovinylfuran derivatives against leishmania in vitro and in vivo. | despite recent advances in the treatment of some forms of leishmaniasis, the available drugs are still far from ideal due to inefficacy, parasite resistance, toxicity and cost. the wide-spectrum antimicrobial activity of 2-nitrovinylfuran compounds has been described, as has their activity against trichomonas vaginalis and other protozoa. thus, the aim of this study was to test the antileishmanial activities of six 2-nitrovinylfurans in vitro and in a murine model of leishmaniasis. minimum paras ... | 2015 | 25946239 |
| iron from haemoglobin and haemin modulates nucleotide hydrolysis in trichomonas vaginalis. | extracellular atp may act as a danger signalling molecule, inducing inflammation and immune responses in infection sites. the ectonucleotidases ntpdase and ecto-5'-nucleotidase are enzymes that modulate extracellular nucleotide levels; these enzymes have been previously characterised in trichomonas vaginalis. iron plays an important role in the complex trichomonal pathogenesis. herein, the effects of iron on growth, nucleotide hydrolysis and ntpdase gene expression in t. vaginalis isolates from ... | 2015 | 25946243 |
| diagnostic value of the papanicolaou smear in lower genital tract infections during pregnancy. | to evaluate the diagnostic value of the pap smear in lower genital tract infections during pregnancy. | 2000 | 25951154 |
| utility of microbiological profile of symptomatic vaginal discharge in rural women of reproductive age group. | symptomatic vaginal discharge is the most frequent symptom in women of reproductive age group. owing to social stigma majority of affected women hesitate to seek medical consultation. therefore the actual incidence of vaginal discharge is much more than what is reported. the aim of the study is to determine the microbiological profile of symptomatic vaginal discharge in rural area and its utility in the management of genital tract infection. | 2015 | 25954668 |
| prevalence and correlates of trichomonas vaginalis infection among female sex workers in a city in yunnan province, china. | sexual transmission is the fastest growing route of hiv transmission in china, and trichomonas vaginalis(tv) can facilitate hiv transmission and acquisition. our goal was to determine the prevalence and correlates of tv infection among female sex workers (fsws). this cross-sectional study was conducted in a city of yunnan province in southern china, with confidential face-to-face interviews and laboratory tests for tv (wet mount) and other sexually transmitted infections. a total of 734 fsws par ... | 2016 | 25957327 |
| anti-trichomonas vaginalis properties of the oil of amomum tsao-ko and its major component, geraniol. | trichomonosis, caused by the flagellate protozoan trichomonas vaginalis, is the most common non-viral sexually transmitted disease (std) and 5-nitroimidazole drugs are used for the treatment. however, a growing number of t. vaginalis isolates are resistant to these drugs, which make it becomes an urgent issue. | 2016 | 25963227 |
| the role of chlamydia trachomatis in high-risk human papillomavirus persistence among female sex workers in nairobi, kenya. | little is known about risk factors for persistent high-risk human papillomavirus (hrhpv) infection in low-income settings, and prior research has not quantified the relative duration of hrhpv infections stratified by risk factors. we compared the duration of hrhpv infection among female sex workers (fsws) by exposure to sexually transmitted infections (stis), using a highly sensitive biomarker assay. | 2015 | 25970306 |
| sequestration of host-cd59 as potential immune evasion strategy of trichomonas vaginalis. | trichomonas vaginalis is known to evade complement-mediated lysis. because the genome of t. vaginalis does not possess dna sequence with homology to human protectin (cd59), a complement lysis restricting factor, we tested the hypothesis that host cd59 acquisition by t. vaginalis organisms mediates resistance to complement killing. this hypothesis was based on the fact that trichomonads are known to associate with host proteins. no cd59 was detected on the surface of t. vaginalis grown in serum-b ... | 2015 | 25976413 |
| synthesis and antiprotozoal activity of mono- and bis-uracil isatin conjugates against the human pathogen trichomonas vaginalis. | a library of mono- and bis-uracil isatin conjugates were synthesized and subjected for the assessment of their in vitro activity against the protozoal pathogen trichomonas vaginalis. the structure activity studies (sar) revealed that the bis-uracil-isatin based conjugates were more effective than their corresponding mono conjugates in inhibiting the growth of t. vaginalis at approximately 10 μm with no visual effect on mammalian cells at the same concentration. | 2015 | 25999204 |
| vulvovaginitis: screening for and management of trichomoniasis, vulvovaginal candidiasis, and bacterial vaginosis. | to review the evidence and provide recommendations on screening for and management of vulvovaginal candidiasis, trichomoniasis, and bacterial vaginosis. | 2015 | 26001874 |
| evaluating hiv prevention programs: herpes simplex virus type 2 antibodies as biomarker for sexual risk behavior in young adults in resource-poor countries. | measuring effectiveness of hiv prevention interventions is challenged by bias when using self-reported knowledge, attitude or behavior change. hiv incidence is an objective marker to measure effectiveness of hiv prevention interventions, however, because new infection rates are relatively low, prevention studies require large sample sizes. herpes simplex virus type 2 (hsv-2) is similarly transmitted and more prevalent and could thus serve as a proxy marker for sexual risk behavior and therefore ... | 2015 | 26010772 |
| prevalence of trichomoniasis among women in kermanshah, iran. | trichomoniasis, caused by trichomonas vaginalis, is the most common sexually transmitted disease (std) in the world with estimates of 7-8 million infections annually in the united states and 180 million globally. | 2015 | 26019904 |
| rho gtpases as pathogen targets: focus on curable sexually transmitted infections. | pathogens have evolved highly specialized mechanisms to infect hosts. several microorganisms modulate the eukaryotic cell surface to facilitate their engulfment. once internalized, they hijack the molecular machinery of the infected cell for their own benefit. at different stages of phagocytosis, particularly during invasion, certain pathogens manipulate pathways governed by small gtpases. in this review, we focus on the role of rho proteins on curable, sexually transmitted infections caused by ... | 2015 | 26023809 |
| prevalence of the genital tract bacterial infections after vaginal reconstructive surgery. | due to frequent childbirth, heavy lifting and the structure of the lives of rural women in shahrekord region, iran, cystocele and rectocele are of the main medical problems of the women in this area and for its correction, vaginal reconstructive surgery is needed which causes infection. the purpose of this study was to identify the bacteria causing infection after vaginal reconstructive surgery and performing antibiogram to help these patients for faster recovery. patients enrolled this study we ... | 2014 | 26031026 |
| population structure and genetic diversity of the parasite trichomonas vaginalis in bristol, uk. | the protozoan parasite trichomonas vaginalis is the causative agent of trichomoniasis, an extremely common, but non-life-threatening, sexually-transmitted disease throughout the world. recent population genetics studies of t. vaginalis have detected high genetic diversity and revealed a two-type population structure, associated with phenotypic differences in sensitivity to metronidazole, the drug commonly used for treatment, and presence of t. vaginalis virus. there is currently a lack of data o ... | 2015 | 26051885 |
| characteristics of women enrolled into a randomized clinical trial of dapivirine vaginal ring for hiv-1 prevention. | women in sub-saharan africa are a priority population for evaluation of new biomedical hiv-1 prevention strategies. antiretroviral pre-exposure prophylaxis is a promising prevention approach; however, clinical trials among young women using daily or coitally-dependent products have found low adherence. antiretroviral-containing vaginal microbicide rings, which release medication over a month or longer, may reduce these adherence challenges. | 2015 | 26061040 |
| overdiagnosis of urinary tract infection and underdiagnosis of sexually transmitted infection in adult women presenting to an emergency department. | urinary tract infections (utis) and sexually transmitted infections (stis) are commonly diagnosed in emergency departments (eds). distinguishing between these syndromes can be challenging because of overlapping symptomatology and because both are associated with abnormalities on urinalysis (ua). we conducted a 2-month observational cohort study to determine the accuracy of clinical diagnoses of uti and sti in adult women presenting with genitourinary (gu) symptoms or diagnosed with gu infections ... | 2015 | 26063863 |
| the incidence of trichomonas vaginalis infection in women attending nine sexually transmitted diseases clinics in the usa. | trichomoniasis (tv) is associated with an increased risk of acquisition of sexually transmitted diseases (stds) and hiv. the purpose of this study is to evaluate factors associated with incidence tv among female std clinic attendees in the usa. | 2016 | 26071390 |
| comparison between mixed lysate antigen and α-actinin antigen in elisa for serodiagnosis of trichomoniasis. | the aim of this study was to identify an antigen suitable for elisa for serodiagnosis of trichomonas vaginalis (t. vaginalis) infection. mixed lysate antigen (ag) from eight strains of t. vaginalis and recombinant α-actinin protein was compared. the sera of three groups were examined by elisa: 73 women infected with trichomoniasis served as a positive control, 31 male volunteers as a negative control, and 424 women attending an outpatient health screening at hanyang university guri hospital. bas ... | 2015 | 26072305 |
| t. vaginalis infection is associated with increased il-8 and tnfr1 levels but with the absence of cd38 and hladr activation in the cervix of esn. | trichomonas vaginalis infection is associated with an increased risk of hiv infection in exposed-seronegative women (esn) despite their unique immune quiescent profile. it is important to understand possible mechanisms, such as recruitment of activated t cells, by which t. vaginalis could facilitate hiv infection in this population. | 2015 | 26083468 |
| diagnosis and treatment of bacterial prostatitis. | prostate inflammation is a common syndrome, especially in men under 50. it usually presents with voiding symptoms and pain in the genitourinary area, and sometimes as sexual dysfunction. based on clinical and laboratory characteristics, prostatitis is classified as acute bacterial prostatitis, chronic bacterial prostatitis, chronic inflammatory and non-inflammatory prostatitis or chronic pelvic pain syndrome, and asymptomatic inflammatory prostatitis. bacterial prostatitis is most often caused b ... | 2015 | 26086164 |
| trichomonas vaginalis cysteine proteinases: iron response in gene expression and proteolytic activity. | we focus on the iron response of trichomonas vaginalis to gene family products such as the cysteine proteinases (cps) involved in virulence properties. in particular, we examined the effect of iron on the gene expression regulation and function of cathepsin l-like and asparaginyl endopeptidase-like cps as virulence factors. we addressed some important aspects about cps genomic organization and we offer possible explanations to the fact that only few members of this large gene family are expresse ... | 2015 | 26090464 |
| genetic diversity of trichomonas vaginalis clinical isolates from henan province in central china. | trichomonas vaginalis is a flagellated protozoan parasite that infects the human urogenital tract, causing the most common non-viral, sexually transmitted disease worldwide. in this study, genetic variants of t. vaginalis were identified in henan province, china. fragments of the small subunit of nuclear ribosomal rna (18s rrna) were amplified from 32 t. vaginalis isolates obtained from seven regions of henan province. overall, 18 haplotypes were determined from the 18s rrna sequences. each samp ... | 2015 | 26103990 |
| p transposable elements in drosophila and other eukaryotic organisms. | p transposable elements were discovered in drosophila as the causative agents of a syndrome of genetic traits called hybrid dysgenesis. hybrid dysgenesis exhibits a unique pattern of maternal inheritance linked to the germline-specific small rna piwi-interacting (pirna) pathway. the use of p transposable elements as vectors for gene transfer and as genetic tools revolutionized the field of drosophila molecular genetics. p element transposons have served as a useful model to investigate mechanism ... | 2015 | 26104714 |
| trypanocidal, trichomonacidal and cytotoxic components of cultivated artemisia absinthium linnaeus (asteraceae) essential oil. | artemisia absinthium is an aromatic and medicinal plant of ethnopharmacological interest and it has been widely studied. the use ofa. absinthium based on the collection of wild populations can result in variable compositions of the extracts and essential oils (eos). the aim of this paper is the identification of the active components of the vapour pressure (vp) eo from a selected and cultivated a. absinthium spanish population (t2-11) against two parasitic protozoa with different metabolic pathw ... | 2015 | 26107187 |
| cytomorphometric and morphological analysis in women with trichomonas vaginalis infection: micronucleus frequency in exfoliated cervical epithelial cells. | the aim of this study was to explore the cytomorphometric and morphological effects of trichomonas vaginalis in exfoliated epithelial cells. | 2015 | 26112451 |
| changes in the contribution of genital tract infections to hiv acquisition among kenyan high-risk women from 1993 to 2012. | the objective of this study was to understand temporal trends in the contribution of different genital tract infections to hiv incidence over 20 years of follow-up in a cohort of high-risk women. | 2015 | 26125141 |
| rna biosignatures in adolescent patients in a pediatric emergency department with pelvic inflammatory disease. | adolescents are at high risk for pelvic inflammatory disease (pid). because accurate diagnosis of pid is difficult, and complications of untreated pid are significant, novel methods to improve diagnosis are essential. | 2015 | 26125533 |
| synthetic sirnas effectively target cystein protease 12 and α-actinin transcripts in trichomonas vaginalis. | the flagellated protozoan trichomonas vaginalis (t. vaginalis) causes trichomoniasis, a reproductive tract infection, in humans. trichomoniasis is the most common non-viral sexually transmitted disease worldwide. in addition to direct consequences such as infertility and abortion, there are indications that trichomoniasis favours development of prostate cancer and it has also been associated with increased risk of spreading human immunodeficiency virus and papillomavirus infections. reports from ... | 2015 | 26134763 |
| prevalence of trichomonas vaginalis infection in symptomatic and asymptomatic women in central vietnam. | the diffusion of trichomoniasis in vietnam has been scarcely studied. the aim of this study was to investigate the prevalence of trichomoniasis in a group of symptomatic and asymptomatic women in central vietnam. relationships between education, socioeconomical and marital status, and sexual behavior with infection have also been investigated. | 2015 | 26142677 |
| [possibility for luminescence identification of different trichomonas vaginalis forms]. | the paper presents the results of examining the morphology of different forms of trichomonas vaginalis by indirect immunofluorescence. fluorescence microscopy revealed that the typical forms of vaginal trichomonads showed a very bright light green glow, around the periphery of a cell in particular; the atypical forms of trichomonads emitted in the green spectral region less brilliantly and evenly. trichomonas fluorescence intensity was measured by spectrofluorescence assay. the experimental find ... | 2015 | 26152037 |
| human papillomavirus positivity in women undergoing intrauterine insemination has a negative effect on pregnancy rates. | sexually transmitted infections are a major cause of infertility. human papillomavirus (hpv) infection is one of the most common viral infections of the female genital tract. only a limited number of studies have investigated the influence of hpv on fertility and its impact remains controversial. | 2016 | 26160018 |
| high rates of double-stranded rna viruses and mycoplasma hominis in trichomonas vaginalis clinical isolates in south brazil. | trichomonas vaginalis is the etiological agent of trichomoniasis, the most common non-viral sexually transmitted disease (std) in world, with 276.4 million new cases each year. t. vaginalis can be naturally infected with mycoplasma hominis and trichomonasvirus species. this study aimed to evaluate the prevalence of t. vaginalis infected with four distinct t. vaginalis viruses (tvvs) and m. hominis among isolates from patients in porto alegre city, south brazil. an additional goal of this study w ... | 2015 | 26160539 |
| mucosal blood group antigen expression profiles and hiv infections: a study among female sex workers in kenya. | the abo blood group antigens are carbohydrate moieties expressed on human red blood cells however; these antigens can also be expressed on some other cells particularly the surface of epithelial cells and may be found in mucosal secretions. in many human populations 80% secrete abo antigens (termed 'secretors') while 20% do not (termed 'non-secretors'). furthermore, there are disease conditions that are associated with secretor status. | 2015 | 26186209 |
| large two-centre study into the prevalence of mycoplasma genitalium and trichomonas vaginalis in the netherlands. | mycoplasma genitalium and trichomonas vaginalis are common sexually transmitted infections (stis). in the netherlands, testing for m. genitalium and t. vaginalis is not recommended for first-line sti screening. recent reports about the increasing antimicrobial resistance in m. genitalium raise concern about the adequacy of current empirical treatment regimens. it is necessary to have insight in the prevalence of m. genitalium and t. vaginalis in order to evaluate current first-line sti screening ... | 2016 | 26199286 |
| nitric oxide maintains cell survival of trichomonas vaginalis upon iron depletion. | iron plays a pivotal role in the pathogenesis of trichomonas vaginalis, the causative agent of highly prevalent human trichomoniasis. t. vaginalis resides in the vaginal region, where the iron concentration is constantly changing. hence, t. vaginalis must adapt to variations in iron availability to establish and maintain an infection. the free radical signaling molecules reactive oxygen species (ros) and reactive nitrogen species (rns) have been proven to participate in iron deficiency in eukary ... | 2015 | 26205151 |
| management of non-gonococcal urethritis. | non-gonococcal urethritis (ngu), or inflammation of the urethra, is the most common treatable sexually transmitted syndrome in men, with approximately 20-50 % of cases being due to infection with chlamydia trachomatis and 10-30 % mycoplasma genitalium. other causes are ureaplasma urealyticum, trichomonas vaginalis, anaerobes, herpes simplex virus (hsv) and adenovirus. up to half of the cases are non-specific. urethritis is characterized by discharge, dysuria and/or urethral discomfort but may be ... | 2015 | 26220178 |
| persistence of trichomonas vaginalis serostatus in men over time. | previous epidemiologic studies have observed positive associations between trichomonas vaginalis (tv) serostatus and both prostate cancer (pca) risk and mortality. however, only a few small older studies have examined tv antibody persistence over time, all of which were composed mainly of female patients. therefore, we examined tv antibody persistence over time, as well as intra-individual variability, among middle- to older-aged men in the southern community cohort study (sccs). | 2015 | 26223890 |
| polyamine quinoline rhodium complexes: synthesis and pharmacological evaluation as antiparasitic agents against plasmodium falciparum and trichomonas vaginalis. | a series of mono- and bis-salicylaldimine ligands and their corresponding rh(i) complexes were prepared. the compounds were characterised using standard spectroscopic techniques including nmr, ir spectroscopy and mass spectrometry. the salicylaldimine ligands and complexes were screened for antiparasitic activity against two strains of plasmodium falciparum i.e. the nf54 cq-sensitive and k1 cq-resistant strain as well as against the g3 isolate of trichomonas vaginalis. the monomeric salicylaldim ... | 2015 | 26226082 |
| value of bacterial culture of vaginal swabs in diagnosis of vaginal infections. | vaginal and cervical swab culture is still very common procedure in our country's everyday practice whereas simple and rapid diagnostic methods have been very rarely used. the aim of this study was to show that the employment of simple and rapid diagnostic tools [vaginal fluid wet mount microscopy (vfwmm), vaginal ph and potassium hydroxide (koh) test] offers better assessment of vaginal environment than standard microbiologic culture commonly used in serbia. | 2015 | 26226725 |
| effect of verbascum thapsus ethanol extract on induction of apoptosis in trichomonas vaginalis in vitro. | trichomoniasis is a sexually transmitted disease (std) caused by a tiny parasite called trichomonas vaginalis. metronidazole is used as routine treatment of disease. some reports have confirmed the potential carcinogenic and teratogenic effects of this drug on fetus and indication of drug resistance. verbascum thapsus belongs to the family of scorphulariaceae. its antiinflammatory properties, disinfectant and skin healing effects are well known. this plant has been used to treat diarrhea and gen ... | 2015 | 26239850 |
| medical devices; immunology and microbiology devices; classification of trichomonas vaginalis nucleic acid assay. final order. | the food and drug administration (fda) is classifying a trichomonas vaginalis nucleic acid assay into class ii (special controls). the agency is classifying the device into class ii (special controls) in order to provide a reasonable assurance of safety and effectiveness of the device. | 2015 | 26241999 |
| trichomonas vaginalis: a review of epidemiologic, clinical and treatment issues. | trichomonas vaginalis (tv) is likely the most common non-viral sexually transmitted infection (sti) in the world. it is as an important source of reproductive morbidity, a facilitator of hiv transmission and acquisition, and thus it is an important public health problem. despite its importance in human reproductive health and hiv transmission, it is not a reportable disease and surveillance is not generally done. this is problematic since most persons infected with tv are asymptomatic. metronida ... | 2015 | 26242185 |
| anti-retroviral lectins have modest effects on adherence of trichomonas vaginalis to epithelial cells in vitro and on recovery of tritrichomonas foetus in a mouse vaginal model. | trichomonas vaginalis causes vaginitis and increases the risk of hiv transmission by heterosexual sex, while tritrichomonas foetus causes premature abortion in cattle. our goals were to determine the effects, if any, of anti-retroviral lectins, which are designed to prevent heterosexual transmission of hiv, on adherence of trichomonas to ectocervical cells and on tritrichomonas infections in a mouse model. we show that trichomonas asn-linked glycans (n-glycans), like those of hiv, bind the manno ... | 2015 | 26252012 |
| comparison of the effect of vaginal zataria multiflora cream and oral metronidazole pill on results of treatments for vaginal infections including trichomoniasis and bacterial vaginosis in women of reproductive age. | effect of zataria multiflora on bacterial vaginosis and trichomonas vaginalis is shown in vivo and in vitro. we compare the effectiveness of zataria multiflora cream and oral metronidazole pill on results of treatment for vaginal infections including trichomonas and bacterial vaginosis; these infections occur simultaneously. the study included 420 women with bacterial vaginosis, trichomonas vaginalis, or both infections together, who were randomly divided into six groups. criteria for diagnosis ... | 2015 | 26266260 |
| trichomonas vaginalis infection in a tertiary care vaginitis center. | trichomonas vaginalis infection (tvi) is one of the most common sexually transmitted diseases in the united states. we sought to determine the features of tvi in a referral-based vaginitis center, focusing on diagnosis and treatment of difficult cases. | 2015 | 26267873 |
| sexually transmitted pathogens, depression, and other manifestations associated with premenstrual syndrome. | this study investigated whether sexually transmitted infections and lifestyle variables are associated with premenstrual syndrome (pms) as well as particular manifestations commonly associated with pms. data were gathered from medical records of 500 regularly cycling women. the following infectious agents were investigated: human papillomavirus, chlamydia trachomatis, neisseria gonorrheae, gardnerella vaginalis, candida albicans, and trichomonas vaginalis. bivariate tests and multivariate logist ... | 2015 | 26272230 |
| prevalence of microorganisms co-infections in human papillomaviruses infected women in northern china. | due to scarce data on the prevalence of genital microorganism infections among individuals with human papillomavirus (hpv) infections, the present study aimed to evaluate microorganism co-infections and associated risk factors in hpv-infected women in northern china. | 2016 | 26280325 |
| prevalence of and risk factors for bacterial vaginosis among women of reproductive age attending cervical screening in southeastern brazil. | to determine the prevalence of and risk factors for bacterial vaginosis. | 2015 | 26283224 |
| distribution of human papillomavirus (hpv) genotypes and bacterial vaginosis presence in cervical samples from paraguayan indigenous. | to determine the frequency of human papillomavirus (hpv) types and to assess bacterial vaginosis (bv) possible associations with cervical infections in indigenous paraguayan women of the department of presidente hayes. | 2015 | 26283550 |
| trichomonas vaginalis and mycoplasma genitalium: age-specific prevalence and disease burden in men attending a sexually transmitted infections clinic in amsterdam, the netherlands. | men are not routinely tested for trichomonas vaginalis (tv) and mycoplasma genitalium (mg) in the netherlands and, therefore, very few studies have looked into their prevalence and/or role in urogenital complaints in the dutch male population. | 2016 | 26283740 |