Publications

the use of dc electric fields to promote regeneration in the mammalian nervous system.		2010	3064792
arginyl-trna synthetase from escherichia coli, purification by affinity chromatography, properties, and steady-state kinetics.	a blue sephadex g-150 affinity column adsorbs the arginyl-trna synthetase of escherichia coli k12 and purifies it with high efficiency. the relatively low enzyme content was conveniently purified by deae-cellulose chromatography, affinity chromatography, and fast protein liquid chromatography to a preparation with high activity capable of catalyzing the esterification of about 23,000 nmol of arginine to the cognate trna per milligram of enzyme within 1 min, at 37 degrees c, ph 7.4. the turnover ...	1988	3064807
arginyl-trna synthetase from escherichia coli, purification by affinity chromatography, properties, and steady-state kinetics.	a blue sephadex g-150 affinity column adsorbs the arginyl-trna synthetase of escherichia coli k12 and purifies it with high efficiency. the relatively low enzyme content was conveniently purified by deae-cellulose chromatography, affinity chromatography, and fast protein liquid chromatography to a preparation with high activity capable of catalyzing the esterification of about 23,000 nmol of arginine to the cognate trna per milligram of enzyme within 1 min, at 37 degrees c, ph 7.4. the turnover ...	1988	3064807
complications and fetal outcome in diabetic pregnancy. intensified conventional versus insulin pump therapy.	from 1978 to 1986 a total of 189 pregnant diabetic women gave birth at our hospital. in this randomized prospective study the influence of maternal diabetes treatment in normoglycemic patients, continuous subcutaneous insulin infusion (n = 48) versus intensified conventional treatment (n = 41), is evaluated. these two groups of patients are further compared to patients (n = 28) who underwent conventional diabetes treatment during pregnancy. it can be shown from our data that the rate of complica ...	2011	3065158
exercise testing in children.		2011	3065707
serological response to plasmid-encoded antigens in children and adults with shigellosis.	the immunological response to plasmid-encoded antigens of virulent shigella was determined in thai children less than 4 yr of age and in thai adults by immunoblot analysis and elisa. forty-two percent (8/19) of thai children and 4% (1/22) of thai adults with shigellosis developed a greater than or equal to 4-fold rise in igg antibody titer to water-extracted antigens of shigella flexneri m90t by elisa (p = 0.006). two children and one lactating mother with shigellosis developed a 4-fold rise in ...	1988	3066570
[use of prostacyclin in patients with ischemic stroke. a double-blind method ii].	thirty patients with acute ischaemic stroke were allocated randomly into a group treated with prostacyclin and a group receiving placebo. the treatment was started 24 to 72 hours after the onset of stroke. prostacyclin sodium (wellcome, u.k. or chinoin, hpr) or its solvent (glycine buffer) were administered intravenously once daily during 2 weeks in 6-hour infusions. prostacyclin was infused at rates of 2.5-5.0 ng/kg/min. statistically significant improvement appeared from the second day on in t ...	2010	3067105
[use of prostacyclin in patients with ischemic stroke. a double-blind method ii].	thirty patients with acute ischaemic stroke were allocated randomly into a group treated with prostacyclin and a group receiving placebo. the treatment was started 24 to 72 hours after the onset of stroke. prostacyclin sodium (wellcome, u.k. or chinoin, hpr) or its solvent (glycine buffer) were administered intravenously once daily during 2 weeks in 6-hour infusions. prostacyclin was infused at rates of 2.5-5.0 ng/kg/min. statistically significant improvement appeared from the second day on in t ...	2010	3067105
regulation of urea cycle enzymes.		1988	3067149
[characteristics of the course of acute dysentery in a 5-year-old child complicated 3 times by intestinal invagination].		1988	3067205
[pharmacokinetics of non-steroidal anti-inflammatory agents in the elderly].		2011	3067421
is hysteroscopy of value in the investigation of female infertility?	a prospective multicentre study was designed to ascertain the value of hysteroscopy in the evaluation of female infertility. the study comprises 619 co2 hysteroscopies in women complaining of infertility. four hundred and ninety nine examinations (80%) were performed without anaesthesia or cervical dilatation. twenty eight cases of malformation were diagnosed. adhesions were found in 68 patients (11%), polypi in 56 (9.1%) and submucous fibroids in 51 (8.2%). endometrial hyperplasia was diagnosed ...	2011	3067483
immunosuppressive effects of blood transfusion in anaesthesia and surgery.	the immunosuppressive effects of blood transfusion at surgical operations become manifest as enhanced graft survival, increased cancer recurrence and decreased patient survival, and increased susceptibility to postoperative infections. blood transfusion in transplant recipients no longer offers this advantage when cyclosporine a is used. the deleterious effects of blood transfusion on the prognosis of some cancers found in the statistical analyses of retrospective studies are considered to be of ...	2010	3067486
immunosuppressive effects of blood transfusion in anaesthesia and surgery.	the immunosuppressive effects of blood transfusion at surgical operations become manifest as enhanced graft survival, increased cancer recurrence and decreased patient survival, and increased susceptibility to postoperative infections. blood transfusion in transplant recipients no longer offers this advantage when cyclosporine a is used. the deleterious effects of blood transfusion on the prognosis of some cancers found in the statistical analyses of retrospective studies are considered to be of ...	2010	3067486
dexamethasone suppression test.	a connection between a high level of plasma cortisol and psychopathology has long been observed. in depressive patients increased plasma cortisol and non-suppression to the dexamethasone suppression test (dst) has often been described. in this study it was found that endogenously depressed patients more often than non-endogenously depressed patients showed abnormal results to the dst. no difference was found in delta max tsh between suppressors and non-suppressors to the dst.	2011	3067539
dopamine-regulated protein phosphorylation in the basal ganglia.		2011	3067550
physiological and behavioral aspects of stress in adolescence.	gonadal and adrenal hormone levels appear to be linked to the stressors experienced by young adolescents. adjustment problems were accompanied by a profile of lower gonadal steroids and higher adrenal androgen levels, primarily androstenedione. later gonadal maturation may be a result of stress suppressing the reproductive axis. higher levels of androstenedione may be indicative of chronic levels of stress. however, the findings for androstenedione are complicated by the fact that androstenedion ...	1988	3067560
leukocyte chemotaxis.	monocyte chemotaxis is a function of mononuclear phagocytic system cells that enables migration toward the focus of infection and inhibition of microorganism growth and proliferation. in this paper we review the chemotactic phenomena following becker's scheme that distinguishes three phases: recognition, transduction and the effector phase. the recognition phase is comprised of the interaction of a chemotactic agent with a receptor located on the cell surface. we cite the multiple chemoattractan ...	2011	3067567
alcohol-related symptoms in heterogeneous families of hospitalized alcoholics.	heterogeneity in the clinical symptoms of alcohol abuse was examined in 243 men and 305 women from families of hospitalized alcoholics, who had demonstrated different patterns of inheritance of susceptibility to alcoholism. discriminant analysis was utilized to identify nine alcoholic symptoms that distinguished male relatives of alcoholic men from those of alcoholic women. inability to abstain from alcohol, fighting and reckless driving while intoxicated, and alcohol treatment other than alcoho ...	2011	3067614
progress in understanding the pathophysiology of treatment-related fluctuations in parkinson's disease.		2011	3067652
[academic dissertations of military pharmacists on the history of pharmacy].		2011	3067684
valvular function of the heart after cardiac transplantation.		2011	3067715
experience with early quadruple immunosuppressive therapy in heart transplantation.		2011	3067718
the 'bn2' gene, a regulator for the onset of chromosome condensation.		2011	3067728
ciprostene in patients with peripheral vascular disease (pvd). an open-label, tolerance trial.	epoprostenol (prostacyclin) has been studied with various success in patients with peripheral vascular disease (pvd). we investigated the tolerance of a new, stable prostacyclin derivative ciprostene (9-beta-methyl carbacyclin) in 9 pvd patients. the drug was infused intravenously for 8 hours a day, once a week for 4 consecutive weeks, at a dose of 120 ng/kg/min. there were 6 men and 3 women with a mean age of 63 years (42-78). the pvd was verified by arteriography (9 patients) and by clinical f ...	2010	3068680
does measurement of urinary rare proteins provide diagnostic significance in glomerular diseases?		2011	3069315
genetic relatedness of the basic replicon of the virulence plasmid in shigellae and enteroinvasive escherichia coli.	the regions required for replication (rep) and for stable maintenance (stb) of the 230 kilobase virulence plasmid, pmysh6000, in shigella flexneri 2a ysh6000 were identified on the restriction enzyme sa/l fragments, c and o, respectively. the stable plasmid, pmysh6610, consisting of adjacent fragments c and o was found to belong to the incompatibility group fl. in all strains of shigellae and enteroinvasive escherichia coli (eiec) tested, virulence plasmids were found to be highly homologous wit ...	1988	3070262
[vitamin d as an immuno-hematopoietic hormone. new perspectives on a previously known substance].	1,25-dihydroxyvitamin d3 (1.25[oh]2d3), the most active metabolite of vitamin d3, plays an important role in bone and mineral metabolism. there is growing evidence that the vitamin d endocrine system may be important in other systems as well: 1,25(oh)2d3 is synthesized in extrarenal tissue. macrophages from both normal human individuals and patients with sarcoidosis are capable of producing 1,25(oh)2d3. specific receptors for 1,25(oh)2d3 are present in a number of cells and tissues other than th ...	1988	3070739
[the importance of secondary immune deficiencies in the pathogenesis of dysentery].	some immunity indices were studied in patients with acute dysentery. the number of total and active t-lymphocytes, t mu- and t gamma-cells, t-rabbit, t-staphylococcal, b-total and b-lymphocytes forming rosettes with mouse erythrocytes were determined for assessment of the immune status. changes in the above indices with relation to the severity of the disease were noted. suppression of the t- and b-systems of immunity were noticeable in patients with a severe and lingering course of disease. del ...	1988	3070808
[free-radical oxidation of blood plasma lipids in patients with acute intestinal infections].	blood plasma free radical lipid oxidation was studied in 98 patients with acute dysentery (ad) and 64 patients with food toxinfection (fti). free radical lipid oxidation was assessed by the intensity of chemiluminescence and the level of lipid peroxides. activation of blood plasma lipid peroxidation was established with relation to a clinical variant of the disease. the effect of indomethacin on the parameters of free radical lipid oxidation was noted in patients with ad and fti.	1988	3070810
[on the anniversary. 50 years of the journal of rheumatology. its first editor: public health officer professor dr. med. paul köhler, bad elster].		2011	3071033
nucleotide sequence of the invasion plasmid antigen b and c genes (ipab and ipac) of shigella flexneri.	the nucleotide sequence of a 4.8 kilobase (kb) hindiii fragment from pwr100, the virulence plasmid of shigella flexneri 5, was determined and analysed. this fragment encodes polypeptides b (62 kilodalton, kd) and c (43 kd) which have already been described as two of the four immunogenic polypeptides of shigellae. the nucleotide sequence revealed that in addition to the ipab and ipac genes encoding polypeptides b and c, a third complete open reading frame was found within the fragment. the gene, ...	1988	3071655
ultrasound in the diagnosis of splenic abscess. case report.		2011	3071730
chronic shigella infection in an hiv seropositive patient--ontario.		1988	3072101
outbreak of shigella flexneri in a nursing home--alberta.		1988	3072103
plasmid mediated drug resistance in shigella flexneri serotypes 1-6 during 1974-85.		1988	3072296
diphtheria toxin entry: protein translocation in the reverse direction.		2005	3072713
[an analysis of distribution of shigella groups for thirty-seven years (1949-1985) in china].		1988	3073017
[evaluation of selective properties of mac conkey's medium enriched with potassium tellurite for growing shigella and yersinia strains].		1988	3073281
[mediterranean kaposi's sarcoma. associated pathology in a case study of 100 patients].		2011	3074041
shigellemia in an infant with intractable diarrhea.		1988	3074059
laboratory studies on the mode of action and application of antiestrogen for breast cancer therapy.		1988	3074131
laboratory studies on the mode of action and application of antiestrogen for breast cancer therapy.		1988	3074131
[separation of shigella enterotoxin and immunosuppression factors].		1988	3074243
[detection and characterization of collagenolytic activity of serine proteases of the subtilisin type].		1988	3074903
[infantile shigella infections in region ix].		1988	3075065
effect of fermentation of ghanaian maize dough on the survival and proliferation of 4 strains of shigella flexneri.	fermented and non-fermented ghanaian maize dough was seeded with approximately 10(7) colony forming units of 4 strains of shigella flexneri which had been isolated from patients with dysentery. in the non-fermented maize dough (ph 6.2) the shigellae were detectable in large numbers for up to 24 h after exposure. in the maize dough that had been fermented for 3 d (ph 3.2) 3 strains were detectable in small numbers for up to 6 h after inoculation. thereafter none was isolated. the fourth strain, t ...	1988	3076718
antibiotic resistance among shigella species isolated in tehran, iran.	a study of adult patients with gastroenteritis was carried out over an 18-month period from march 1984 until august 1985, with the aim of detecting shigella species and studying their antibiotic resistance pattern. two thousand four hundred and eighteen stool specimens were examined and 230 isolations of shigella were made, a detection rate of 9.5%. of the 230 isolates, 61.2% were found to be sh. flexneri, and resistance to ampicillin, chloramphenicol, co-trimoxazole and tetracycline was extreme ...	1988	3077023
[beef-extract agar with sodium nucleinate as a medium for storage and stabilization of biological properties of shigella].		1986	3078175
[shigella serotypes and drug resistance patterns of strains isolated in etimesgut, turkey, in 1987].	drug resistance patterns of shigella strains were investigated in a prospective manner in etimesgut district during a period of 1 year. thirty strains shigella were isolated, belonged to three subgroups with preponderance of sh. flexneri (70%), followed by sh. sonnei (27%) and sh. boydii (3%). the resistance was highest with streptomycin (80%), followed by trimethoprim-sulfamethoxazole (tmp-smz) (53%) and ampicillin (43%). only three strains (10%) were sensitive to all eight antibiotics tested. ...	1988	3078794
[hearing disturbances and hearing loss of occupational origin in dentistry].		2011	3078965
duplex sonography of the venous system.		2011	3078970
[sarcoidosis, today].		2011	3079440
triclonal gammopathy in a patient with plasma cell dyscrasia.	a triclonal gammopathy is an immunoglobulin abnormality in which three discrete monoclonal subpopulations of immunoglobulin molecules are present in a patient's serum. monoclonal and biclonal gammopathies have been studied extensively, but relatively little is known about the much rarer triclonal gammopathies. the case described below illustrates some of the difficulties that this condition can present to the clinician and the clinical laboratory.	2011	3079680
different classes of antibody activities to trichosporon cutaneum antigen in summer-type hypersensitivity pneumonitis by enzyme-linked immunosorbent assay.	to assess the diagnostic value of antibody activities to trichosporon cutaneum antigen in patients with summer-type hypersensitivity pneumonitis in japan, we measured the serum igg, iga, and igm antibodies to saline-soluble antigen of homogenized t. cutaneum cells by enzyme-linked immunosorbent assay (elisa). the igg antibody activity was observed in serum samples from 25 (83%) of the 30 patients and in 9 (82%) of the 11 asymptomatic family members. the iga antibody activity was found in 25 (83% ...	1986	3079979
different classes of antibody activities to trichosporon cutaneum antigen in summer-type hypersensitivity pneumonitis by enzyme-linked immunosorbent assay.	to assess the diagnostic value of antibody activities to trichosporon cutaneum antigen in patients with summer-type hypersensitivity pneumonitis in japan, we measured the serum igg, iga, and igm antibodies to saline-soluble antigen of homogenized t. cutaneum cells by enzyme-linked immunosorbent assay (elisa). the igg antibody activity was observed in serum samples from 25 (83%) of the 30 patients and in 9 (82%) of the 11 asymptomatic family members. the iga antibody activity was found in 25 (83% ...	1986	3079979
acute renal failure associated with acute pyelonephritis and consumption of non-steroidal anti-inflammatory drugs.		2011	3080108
myoclonus and mitochondrial myopathy.	the cns diseases that are associated with mitochondrial myopathy have been reviewed in this chapter. the disorders causing myoclonus have been compared to those in which myoclonus has been reported. both groups have been associated with lactate and pyruvate accumulation, and both have a wide spectrum of clinical and pathologic findings. deficiency of components of the respiratory chain has been offered as an explanation for the mitochondrial accumulation in the muscles of these patients. skeleta ...	2011	3080847
effect of guinea pig or monkey colonic mucus on shigella aggregation and invasion of hela cells by shigella flexneri 1b and 2a.	the effects of guinea pig and rhesus monkey colonic mucus preparations on shigella aggregation and invasion of hela cell monolayers by shigella flexneri serotype 1b, 2a, and 5 strains were investigated. guinea pig mucus caused agglutination of s. flexneri serotype 1b but not of s. flexneri serotype 2a or 5. guinea pig mucus also inhibited hela cell invasion by s. flexneri serotypes 1b and 2a. monkey mucus neither agglutinated any shigella strain nor inhibited hela cell invasion.	1986	3081449
characterization of the membrane-bound protein kinase c and its substrate proteins in canine cardiac sarcolemma.	cardiac sarcolemma was purified from canine ventricles. enrichment of the sarcolemmal membranes was demonstrated by the high (na+ + k+)-atpase activity of 28.0 +/- 1.5 mumol pi/mg protein per h and the high concentration of muscarinic receptors with the bmax of 8.2 +/- 2.5 pmol/mg protein as determined by [3h]qnb binding. the purified sarcolemma also contains significant levels of a membrane-bound ca2+ and phospholipid-dependent protein kinase (protein kinase c). to elucidate the protein kinase ...	1986	3082370
basic principles of intravenous nutritional support.	parenteral nutrition has been one of the major advances in clinical medicine in the 20th century. by maintaining or re-establishing optimal nutritional status, one can help to ensure an optimal response to appropriate medical or surgical management of the primary disease process. in order to plan an appropriate nutritional regimen, the health-care provider must be equipped to pursue the following thought processes: understand the consequences of malnutrition. identify the patient who may benefit ...	2011	3082576
[use of bladder biopsy in the study of urinary schistosomiasis].	it is common to find schistosoma eggs in urine, faeces, and biopsies from rectal mucus membranes presently in use. it is less common to observe adults in routine bladder biopsies. the authors report such a case and discuss the importance of the bladder biopsy to estimate tissular inflammatory response which could reflect the host-parasite balance.	1986	3084108
disialoganglioside gd2 distributes preferentially into substrate-associated microprocesses on human melanoma cells during their attachment to fibronectin.	human melanoma cells (m21) actively attach and spread on a fibronectin substrate. indirect immunofluorescence assays with specific monoclonal antibodies directed to the disialoganglioside gd2, the major ganglioside expressed on m21 melanoma cells, indicate that during the cell attachment process this molecule redistributes into microprocesses that make direct contact with the fibronectin substrate. scanning and transmission immunoelectron microscopic studies with anti-gd2 monoclonal antibodies a ...	1986	3084502
disialoganglioside gd2 distributes preferentially into substrate-associated microprocesses on human melanoma cells during their attachment to fibronectin.	human melanoma cells (m21) actively attach and spread on a fibronectin substrate. indirect immunofluorescence assays with specific monoclonal antibodies directed to the disialoganglioside gd2, the major ganglioside expressed on m21 melanoma cells, indicate that during the cell attachment process this molecule redistributes into microprocesses that make direct contact with the fibronectin substrate. scanning and transmission immunoelectron microscopic studies with anti-gd2 monoclonal antibodies a ...	1986	3084502
[clinical experience with high dose rate afterloading interstitial radiation--a preliminary report].		2011	3084688
levels and sources of stress in medical students.	levels of stress, as measured by the general health questionnaire, were assessed in 318 medical students in their fourth year at three british universities. mean scores were higher than those in other groups within the general population, and the estimated prevalence of emotional disturbance was 31.2%, a proportion similar to that reported in medical students in the united states. there were no differences in prevalence or in mean scores of stress between the sexes. twelve (4%) students reported ...	2009	3085772
endogenous luteinizing hormone surge in women during induction of multiple follicular development with pulsatile follicle stimulating hormone.	in this study nine consecutive normally cycling women undergoing in-vitro fertilization (ivf) were superovulated with clomiphene citrate followed by pulsatile 'pure' fsh injected s.c. via a pump (28 iu every 3 h). all women displayed an endogenous lh surge, which was markedly attenuated in most of the cases (peak value 44.5 +/- 5.9 u/l, duration 29.2 +/- 1.2 h, mean +/- sem) as compared to spontaneous cycles. an increase in serum progesterone levels before the onset of the lh surge was seen in o ...	1986	3085995
natural and recombinant interferons inhibit epithelial cell invasion by shigella spp.	the effect of natural and recombinant interferons (ifns) on the abilities of shigella flexneri, s. sonnei, and salmonella typhimurium to invade different human and murine cells was examined. pretreatment of cell monolayers with natural and recombinant ifns reduced the number of shigella-infected cells in a dose-dependent manner. establishment of an anti-invasive cellular state was time dependent, requiring 10 h for 50% inhibition of bacterial invasion. the inhibitory effect of ifn was species sp ...	1986	3086234
measurement of phospholipid turnover in cultured hormone responsive pituitary cells.		1986	3086663
genetic basis for altered idiotype expression in the hyperimmune response to (4-hydroxy-3-nitrophenyl)acetyl hapten.	to assess the significance of somatic point mutation in the hyperimmune response to the hapten np, an in vivo enrichment procedure was followed. mice that expressed high titers of b1-8 idiotopic determinants were selected as donors for serial transfer of small numbers of immune spleen cells into syngeneic irradiated recipient mice. cells expressing b1-8 idiotopic determinants were chosen for enrichment because b1-8 cross-reactive determinants constitute a significant portion of the primary respo ...	1986	3088116
stimulation of arachidonic acid release and eicosanoid biosynthesis in an interleukin 2-dependent t cell line.	previous studies have provided pharmacologic evidence that t lymphocyte function may be regulated in part by the intracellular production of various arachidonic acid (aa) metabolites in response to cellular stimulation. however, the specific aa metabolic capabilities of homogeneous t cell populations have not been clearly defined. in the present studies, we have employed an accessory cell-free t cell line, ht-2, as a model system for the examination of stimulus-induced eicosanoid biosynthesis in ...	2011	3088127
skeletal remodelling in the temporomandibular joint after oblique sliding osteotomy of the mandibular rami.	skeletal remodelling of the temporomandibular joints took place in 80% of cases after oblique sliding osteotomies of the rami. the new bone formation was found in both the condylar and temporal parts of the joint. it was mostly located on the posterior surface of the condyle and in the roof of the temporal part of the joint. no differences in skeletal remodelling were found between wiring and nonwiring cases.	2011	3088149
indications for surgical removal of supernumerary teeth in the premaxilla.	usually supernumerary teeth in the maxilla are removed surgically, often due to retention of the permanent teeth in the region, but in certain cases the supernumerary teeth do not cause alterations in the eruption, position or integrity of the permanent dentition. this study was performed in order to review the indications for such surgical removal. the patient records of 208 patients with supernumerary teeth during the period of 1970-81 were reviewed retrospectively. of these patients, 52 non-o ...	2011	3088155
autotransplantation of maxillary canine teeth. a follow-up of 35 cases up to 4 years.	35 cases of autotransplantation of nonendodontically treated maxillary canines were followed for up to 4 years and were assessed according to loss of the transplanted tooth, onset of sensibility, mobility, intact lamina dura and presence of tooth resorption. the results of this study compare favourably with other studies and favour the hypothesis that little is to be gained by not endodontically treating autotransplanted teeth immediately after splint removal. it is also suggested that immobiliz ...	2011	3088156
the effect of the beta-carboline fg 7142 on the behaviour of male rats in a living cage: an ethological analysis of social and nonsocial behaviour.	the effects of fg 7142, a beta-carboline benzodiazepine receptor partial inverse agonist, on the social behavior of pair-housed rats were investigated. four 6-min dyadic social encounters in a living cage were observed in a paradigm in which one member of a pair of rats was injected. the four injection groups (n = 8) were vehicle control, and fg 7142 at 2.5, 5.0 and 10.0 mg/kg, respectively. all injections were administered 2 min before the start of the first observation trial. compared to the e ...	1986	3088637
study of aldose reductase inhibition in intact lenses by 13c nuclear magnetic resonance spectroscopy.	carbon-13 nuclear magnetic resonance spectroscopy has been used in the study of glucose metabolism, specifically aldose reductase inhibition, in intact rabbit lenses maintained in organ culture. this technique provides an effective method of screening potential inhibitors of aldose reductase under conditions that more closely approximate in vivo conditions than do earlier methods. the aspirin substitutes acetaminophen and ibuprofen were studied as aldose reductase inhibitors and were found to be ...	1986	3088727
transdermal glyceryl trinitrate.		2011	3089054
manpower and training.		2011	3089508
disopyramide phosphate effects on slow and depressed fast responses.	we studied the effects of disopyramide phosphate on explanted neonatal rat ventricle cells exhibiting depressed fast responses or naturally occurring slow response action potentials together with automatic activity. disopyramide suppressed the spontaneous activity at a concentration of 2.5 micrograms/ml with a half-maximal value of 10 micrograms/ml. before spontaneous activity was lost, there was an increase in beating rate possibly related to membrane depolarization. in depressed fast and slow ...	1986	3089566
[cell proliferation in the carcinogenetic processes of tongue carcinoma induced by 4-nitroquinoline-1-oxide in rats. 1. relation between morphology and microvascular architecture of the filiform papillae of dorsal surface of the tongue in normal albino rats].		1986	3090703
button wires in the treatment of mandibular fractures.	button wiring has been used as an alternative to eyelet wiring in the department of oral and dental surgery of birmingham general hospital since 1977. this clinical update reviews 65 patients with mandibular fractures in which button wires were utilised in their treatment.	2010	3091722
role of glutathione in protecting endothelial cells against hydrogen peroxide oxidant injury.	to determine the mechanism responsible for the enhanced susceptibility of endothelial cells to oxidant injury in the absence of glucose, we induced endothelial cell injury with oxygen radicals in the presence of various oxygen radical scavengers and measured endothelial cell levels of glutathione after oxidant injury in the presence and absence of glucose. endothelial cells were damaged with toxic oxygen radicals generated by phorbol myristate acetate (pma)-activated polymorphonuclear leukocytes ...	2010	3091744
treating erythema chronicum migrans of lyme disease.	the efficacy of antibiotic treatment of 117 patients with erythema chronicum migrans of lyme disease was evaluated in terms of the necessity for retreatment and the prevention of the late manifestations of lyme disease. fifty-six patients with a minor form of the illness did not require retreatment and did not develop late manifestations following antibiotic treatment. three pregnant patients were included in this group. fourteen of sixty-one patients with a major form of the illness required re ...	2011	3093544
chloroalanyl antibiotic peptides: antagonism of their antimicrobial effects by l-alanine and l-alanyl peptides in gram-negative bacteria.	a large number of structurally diverse di- and tripeptides containing the alanine racemase inactivator beta-chloro-l-alanine (beta-cl-lala) have been synthesized, and their antibacterial properties in vitro have been evaluated. the dipeptides 1, 3-6, and 8-17 and the tripeptide 20 are all broad-spectrum antibacterial agents with considerable potency against both gram-positive and gram-negative species, but none of these peptides improves dramatically on the antibiotic efficacy of the previously ...	1986	3093682
noradrenergic and opioid mediation of tricyclic-induced reversal of escape deficits caused by inescapable shock pretreatment in rats.	the present study was undertaken to investigate the possible involvement of a noradrenergic and opioid mediation of the reversal by tricyclic antidepressants of escape deficits produced by inescapable shock pretreatment. rats were first exposed to 60 inescapable shocks (15 s duration, 0.8 ma, every min +/- 15 s) and 48 h later subjected, to daily shuttle-box sessions (30 trials/day, iti: 30 s) during 3 consecutive days. twice-daily ip injection of desipramine or clomipramine (total daily dose: 3 ...	1986	3094068
[prevalence of campylobacter jejuni complement fixing antibody in healthy people].		1986	3097197
rash mutants deficient in gtp binding.	single amino acid substitutions were introduced into a region of the rash protein (residues 116, 117, and 119) homologous to a variety of diverse gtp-binding proteins. each of the mutant p21 proteins displayed a significant reduction (10- to 5,000-fold) in gtp binding affinity. activated rash proteins deficient in gtp binding were unaltered in their ability to morphologically transform nih 3t3 cells.	1986	3097518
signals in the phi 29 dna-terminal protein template for the initiation of phage phi 29 dna replication.	the protein-free terminal fragments hindiii b and l, from the left and right ends of phi 29 dna, respectively, but not internal fragments of similar size, were active as templates in the formation of the p3-damp initiation complex in an in vitro system containing purified phi 29 terminal protein p3 and dna polymerase p2, although the activity was lower than that obtained with the phi 29 dna-p3 complex. these results indicate the existence of specific sequences at the ends of phi 29 dna that allo ...	1986	3097958
radioimmunoscintigraphy of human gastric carcinoma xenografts with 125i-labeled monoclonal antibody.	a monoclonal antibody (gc 302) established in our laboratory, which was reactive with gastric carcinoma and other epithelial carcinoma but not with normal gastric mucosa or other malignant tumors of mesenchymal origin, was used to investigate the radioimmunolocalization of tumors. various kinds of target cells (5 x 10(5)) were incubated with 125i-labeled gc 302, and radioactivity was determined with a gamma counter. it was shown that there was a 500- to 1,000-fold increase in counts for gastric ...	1986	3098721
characterization and diagnostic application of a lipopolysaccharide core oligosaccharide-protein conjugate.	shigella sonnei phase ii core oligosaccharide (osphii) was linked covalently with protein (bovine serum albumin or tetanus toxoid) to obtain a conjugate (osphii-protein) of good immunogenicity in rabbits. anti-osphii-protein conjugate sera contained high levels of immunoglobulin g antibodies against the complete core region of sh. sonnei lipopolysaccharide. the antigenic relationships between lipopolysaccharides of r1, r3 and r4 core types using anti-osphii-protein sera were studied. these antis ...	1986	3098854
effect of measles-virus infection and interferon treatment on invasiveness of shigella flexneri in hep2-cell cultures.	the influence of measles-virus infection on the invasiveness of shigella flexneri in hep2-cell cultures was studied. bacterial invasiveness was significantly enhanced in cell cultures incubated with virus before bacterial inoculation. this effect was a function of time after introduction of virus to the cell cultures and of the concentration of virus. the increase in bacterial invasiveness was observed before production of infectious virus particles and before a cytopathic effect was evident. a ...	1986	3098977
separation and quantification of prostaglandins e1 and e2 as their panacyl derivatives using reverse phase high pressure liquid chromatography.	separation and quantification of prostaglandin e1 (pge1) and prostaglandin e2 (pge2) were achieved using reverse phase high performance liquid chromatography (hplc). panacyl bromide (p-(9-anthroyloxy)phenacyl bromide) (pab) derivatives of pge2 and pge1 were prepared. reverse phase hplc using a linear gradient of 56% to 80% acetonitrile in water containing 0.10% acetic acid gave baseline resolution of the two derivatives. a 3 um diameter particle, c18 column provided good resolution and reproduci ...	1986	3099332
a strain of multiform cryptococcus neoformans.		1986	3100152
aids policy development within the department of defense.		2011	3100984
on the mechanism of antithrombotic action of flavonoids.	flavonols (quercetin and rutin) and flavanes (cyanidol and meciadonol) were studied for their effect on non-enzymatic lipid peroxidation, lipoxygenase and cyclo-oxygenase activities, binding to albumin and platelet membranes. these biochemical properties of four flavonoids were compared with respect to their antithrombotic action in vivo and their efficacy at influencing the platelet-endothelium interaction in vitro. all four flavonoids inhibited the ascorbate-stimulated formation of malondialde ...	1987	3101704
doppler studies in the growth retarded fetus and prediction of neonatal necrotising enterocolitis, haemorrhage, and neonatal morbidity.	in 82 consecutive cases of intrauterine growth retardation managed by established criteria fetal doppler studies identified 29 fetuses with absence of end diastolic frequencies in the fetal aorta. these same fetuses were significantly more growth retarded (p less than 0.001) and had an earlier gestational age at delivery (p less than 0.001) than those with end diastolic frequencies present. a subgroup of these cases was analysed in more detail to examine the prognostic value of this phenomenon f ...	2011	3101778
salicylates inhibit paf-acether-induced rat paw oedema when cyclooxygenase inhibitors are ineffective.	the cyclooxygenase inhibitors indomethacin, piroxicam, ibuprofen, naproxen and flurbiprofen failed to block rat paw oedema induced by paf-acether, whereas aspirin and sodium salicylate were effective. two mixed cyclooxygenase and lipoxygenase inhibitors ndga, bw 755c and dexamethasone reduced oedema in a dose - dependently. the selective paf-acether antagonist, bn 52021, was effective against paf-acether at 5 - 20 mg/kg. the lipoxygenase derivates may be involved in paw oedema induced by paf-ace ...	1986	3103172
coagulation defects of aflatoxin intoxicated rabbits.	twelve new zealand white rabbits were intoxicated with aflatoxin b1. most rabbits developed a coagulation defect near the time of death. immediately prior to death there were significant decreases in factors v, vii, and viii coagulant activities and fibrinogen concentration without a change in plasma fibrin(ogen) degradation product concentration, platelet number, and detectable plasma fibrin monomers. microscopic evidence of disseminated intravascular coagulation was present in one rabbit with ...	1987	3103313
characterization of self-transmissible plasmids determining lactose fermentation and multiple antibiotic resistance in clinical strains of klebsiella pneumoniae.	the lactose fermentation (lac+) and antibiotic resistance (r+) phenotypes were conjugally transferred from klebsiella pneumoniae strains (k166, k182, k186, k218, and k220) to salmonella typhi, s. typhimurium, shigella flexneri, and vibrio cholerae. the genes for lactose fermentation and antibiotic resistance were located on the plasmids. further analysis of plasmid dna from these isolates indicated the presence of multiple plasmids (mr ranged less than 2.7 to 70 x 10(6)). the lac+r+ plasmids p16 ...	1987	3107002
osteonectin content in human osteogenesis imperfecta bone shows a range similar to that of two bovine models of oi.	samples of human osteogenesis imperfecta (oi) bone were analyzed for osteonectin content by sds gel electrophoresis and immunodetection on western blots. the oi bone osteonectin content varied from normal to severely depressed. previously, we showed that two clinically identical but genetically unrelated bovine models of oi were differentiated biochemically by their bone osteonectin content: one oi model had normal bone osteonectin while the other was severely depressed in this parameter. the da ...	1987	3107778