Publications
| Title | Abstract | Year Filter | PMID(sorted ascending) Filter |
|---|
| adenosine reduces the reverse mode of the na+/ca(2+) exchanger in ferret cardiac fibres. | the aim of this study was to investigate the effects of adenosine on reverse mode na+/ca(2+) exchange. in intact ferret cardiac trabeculae, na+-free contractures were investigated after treating preparations with ryanodine, a sarcoplasmic reticulum ca(2+) -channel inhibitor, and thapsigargin, a sarcoplasmic reticulum ca(2+) -pump inhibitor added to suppress the sarcoplasmic reticulum function. the effects of adenosine (50-100 nmol/l), adenosine deaminase (ada, 0.1-0.5 u/l), the a1 and a2a recept ... | 2008 | 18418446 |
| severe seasonal influenza in ferrets correlates with reduced interferon and increased il-6 induction. | even though ferrets are one of the principal animal models for influenza pathogenesis, the lack of suitable immunological reagents has so far limited their use in host response studies. using recently established real-time pcr assays for a panel of ferret cytokines, we analyzed the local ferret immune response to human influenza isolates of the h1n1 and h3n2 subtypes that varied in their virulence. we observed that the severity of clinical signs correlated with gross- and histopathological chang ... | 2008 | 18420248 |
| oseltamivir prophylactic regimens prevent h5n1 influenza morbidity and mortality in a ferret model. | current oseltamivir prophylactic regimens may not be as effective against highly pathogenic h5n1 influenza viruses as they are against less pathogenic strains. an optimal regimen is urgently needed. | 2008 | 18422444 |
| clinicopathologic features of a systemic coronavirus-associated disease resembling feline infectious peritonitis in the domestic ferret (mustela putorius). | from 2002 to 2007, 23 ferrets from europe and the united states were diagnosed with systemic pyogranulomatous inflammation resembling feline infectious peritonitis (fip). the average age at the time of diagnosis was 11 months. the disease was progressive in all cases, and average duration of clinical illness was 67 days. common clinical findings were anorexia, weight loss, diarrhea, and large, palpable intra-abdominal masses; less frequent findings included hind limb paresis, central nervous sys ... | 2008 | 18424841 |
| helicobacter animal models. | in this unit, protocols for growing helicobacter organisms on plates or in liquid cultures are presented, followed by protocols for infecting mice with helicobacter felis and h. pylori and for infecting ferrets with h. mustelae. also, a procedure is described for adapting an h. pylori isolate to growth in mice. support protocols describe methods for quantifying numbers of helicobacter organisms, and how to create a growth curve for helicobacter cultures. one important technique in investigating ... | 2001 | 18432759 |
| molecular characterization of a new genotype of cryptosporidium from american minks (mustela vison) in china. | a total of 469 fecal samples were collected from american minks (mustela vison) on a farm in hebei province in china and examined for cryptosporidium by sheather's sugar flotation technique and 8 cryptosporidim isolates were obtained. the partial 18s rrna, 70kda heat shock protein (hsp70), cryptosporidium oocyst wall protein (cowp) and actin genes of six isolates were sequenced. sequence data were analyzed together with known cryptosporidium spp. and genotypes. results of this multi-locus geneti ... | 2008 | 18434024 |
| canine distemper virus in wild ferret-badgers of taiwan. | canine distemper is an acute or subacute, highly contagious, febrile disease that is caused by canine distemper virus (cdv). two cdv-infected wild taiwan ferret-badgers (melogale moschata subauantiaca) were found in kaohsiung county, southern taiwan, in 2005. each case was confirmed by detecting cdv rna in lung and brain tissues. a suspected third case was detected based on clinical signs and histology. these cases are the first record of wildlife infected by cdv in taiwan. it is believed that d ... | 2008 | 18436676 |
| use of a gonadotropin releasing hormone agonist implant as an alternative for surgical castration in male ferrets (mustela putorius furo). | surgical castration in ferrets has been implicated as an etiological factor in the development of hyperadrenocorticism in this species due to a castration-related increase in plasma gonadotropins. in search for a suitable alternative, the effect of treatment with the depot gnrh-agonist implant, deslorelin, on plasma testosterone concentrations and concurrent testes size, spermatogenesis, and the typical musky odor of intact male ferrets was investigated. twenty-one male ferrets, equally divided ... | 2008 | 18439664 |
| long-term outcome of domestic ferrets treated surgically for hyperadrenocorticism: 130 cases (1995-2004). | to determine the long-term survival rate and factors that affect survival time of domestic ferrets treated surgically for hyperadrenocorticism. | 2008 | 18447778 |
| virus growth and antibody responses following respiratory tract infection of ferrets and mice with wt and p/v mutants of the paramyxovirus simian virus 5. | p/v gene substitutions convert the non-cytopathic paramyxovirus simian virus 5 (sv5), which is a poor inducer of host cell responses in human tissue culture cells, into a mutant (p/v-cpi-) that induces high levels of apoptosis, interferon (ifn)-beta, and proinflammatory cytokines. however, the effect of sv5-p/v gene mutations on virus growth and adaptive immune responses in animals has not been determined. here, we used two distinct animal model systems to test the hypothesis that sv5-p/v mutant ... | 2008 | 18456301 |
| comparative histological study of the mammalian facial nucleus. | we performed comparative nissl, klüver-barrera and golgi staining studies of the mammalian facial nucleus to classify the morphologically distinct subdivisions and the neuronal types in the rat, rabbit, ferret, japanese monkey (macaca fuscata), pig, horse, risso's dolphin (grampus griseus), and bottlenose dolphin (tursiops truncatus). the medial subnucleus was observed in all examined species; however, that of the risso's and bottlenose dolphins was a poorly-developed structure comprised of scat ... | 2008 | 18460831 |
| gr-205171 (glaxo wellcome plc). | glaxo wellcome is developing the nk1 antagonist gr-205171 for the potential treatment of chemotherapy- and radiotherapy-induced emesis, post-operative nausea and emesis, and migraine. phase ii trials have commenced for both these indications. gr-205171 has a similar affinity for the nk1 receptor as cp-99994 [176071,193105]. glaxo anticipates nda and maa filings in 2000 [244813]. a trial of gr-205171 in combination with ondansetron demonstrated the combination to be highly effective in the preven ... | 1998 | 18465582 |
| screening monoclonal antibodies for cross-reactivity in the ferret model of influenza infection. | influenza virus infections carry a high public health cost, and pandemics are potentially catastrophic. though the ferret is generally regarded as the best model for human influenza, few reagents are available for the analysis of cellular immunity. we thus screened monoclonal antibodies (mabs) made for identifying immune cells in other species to see if any were cross-reactive. flow cytometric analysis of lymphocytes isolated from blood, spleen, and lung of normal and virus-infected ferrets indi ... | 2008 | 18485358 |
| avian influenza in birds and mammals. | the disease syndromes caused by avian influenza viruses are highly variable depending on the host species infected, its susceptibility and response to infection and the virulence of the infecting viral strain. although avian influenza viruses have a broad host range in general, it is rare for an individual strain or subtype to infect more than one species. the h5n1 highly pathogenic avian influenza virus (hpaiv) lineages of viruses that descended from a/goose/guandong/96 (h5n1 hpaiv) are unusual ... | 2009 | 18485480 |
| heartworm disease in animals and humans. | heartworm disease due to dirofilaria immitis continues to cause severe disease and even death in dogs and other animals in many parts of the world, even though safe, highly effective and convenient preventatives have been available for the past two decades. moreover, the parasite and vector mosquitoes continue to spread into areas where they have not been reported previously. heartworm societies have been established in the usa and japan and the first european dirofilaria days (fedd) conference ... | 2008 | 18486691 |
| comparison of effects of 2 harvesting methods on fat autograft. | fat preparation for vocal-fold injection medialization is typically done by scraping of excised fat or by lipo-aspiration; however, lipo-aspiration is substantially more efficient. considering this, we compared viability of fat tissues obtained by these two techniques. we also examined whether basic fibroblast growth factor (bfgf) would increase cell proliferation in samples harvested by these methods. | 2008 | 18496155 |
| contemporary north american influenza h7 viruses possess human receptor specificity: implications for virus transmissibility. | avian h7 influenza viruses from both the eurasian and north american lineage have caused outbreaks in poultry since 2002, with confirmed human infection occurring during outbreaks in the netherlands, british columbia, and the united kingdom. the majority of h7 infections have resulted in self-limiting conjunctivitis, whereas probable human-to-human transmission has been rare. here, we used glycan microarray technology to determine the receptor-binding preference of eurasian and north american li ... | 2008 | 18508975 |
| plasmid dna-based vaccines protect mice and ferrets against lethal challenge with a/vietnam/1203/04 (h5n1) influenza virus. | plasmid dna (pdna) vaccines represent an alternative to conventional inactivated influenza vaccines that are likely to experience supply constraints during a pandemic. several vaxfectin-formulated pdna vaccines were tested in mice and ferrets for efficacy against a lethal challenge with the highly pathogenic a/vietnam/1203/04 (h5n1) influenza virus strain; the vaccines encoded influenza a virus hemagglutinin (ha), and/or nucleoprotein (np), and m2 protein. complete protection from death and dise ... | 2008 | 18513153 |
| first record of eimeria furonis infection in a ferret, japan, with notes on the usefulness of partial small subunit ribosomal rna gene sequencing analysis for discriminating among eimeria species. | eimeria is a genus of apicomplexan parasites found in a variety of vertebrates including the weasel. at present, three species have been reported in members of the weasel family, but the presence of weasel eimeria in japan have been quite unclear. the identification of eimeria species has been performed based on oocyst morphology, host species, and habitat in the host, but sometimes discriminating among morphologically similar species under light microscopy is impossible. the present study detec ... | 2008 | 18516721 |
| intrageneric diversity of the cytochrome b gene and phylogeny of eurasian species of the genus mustela (mustelidae, carnivora). | to illuminate molecular phylogenetic relationships among eurasian species of the genus mustela (mustelidae, carnivora), we determined nucleotide sequences of the complete mitochondrial cytochrome b gene region (1,140 base pairs). molecular phylogenetic trees, constructed using the neighbor-joining and the maximum likelihood methods, showed the common topology of species relationships to each other. the american mink m. vison first branched off and was positioned very remotely from the other spec ... | 2000 | 18517304 |
| cystic renal disease in the domestic ferret. | cystic renal diseases in domestic ferrets are a common anecdotal finding but have received scant systematic assessment. we performed a 17-y, case-control retrospective analysis of the medical records of 97 ferrets housed at our institution between 1987 and 2004, to determine the prevalence and morphotypes of cystic renal diseases in this species. histologic sections stained with hematoxylin and eosin, masson trichrome, or periodic acid-schiff were evaluated by a comparative pathologist, and stat ... | 2008 | 18524174 |
| intra-abdominal leiomyosarcoma in a ferret (mustela putorius furo): histopathological and immunohistochemical characterization. | a 5 years old female ferret with an abdominal palpable mass confirmed at echo-graphic examination died during an explorative laparotomy. a single lymph-node-like nodule was found adjacent to the intestinal loops. the round mass well circumscribed, solid and white, histologically, at low magnification, appeared encapsulated and built up by a population of atypical spindle cells arranged in interwoven fascicles. the cells had high anisocytosis degree, moderate mitotic activity and prominent nucleo ... | 2008 | 18525177 |
| perception and cortical neural coding of harmonic fusion in ferrets. | this study examined the perception and cortical representation of harmonic complex tones, from the perspective of the spectral fusion evoked by such sounds. experiment 1 tested whether ferrets spontaneously distinguish harmonic from inharmonic tones. in baseline sessions, ferrets detected a pure tone terminating a sequence of inharmonic tones. after they reached proficiency, a small fraction of the inharmonic tones were replaced with harmonic tones. some of the animals confused the harmonic tone ... | 2008 | 18529189 |
| layer-specific expression of multiple cadherins in the developing visual cortex (v1) of the ferret. | cadherins are superfamily of ca2+-dependent transmembrane glycoproteins with more than 100 members. they play a role in a wide variety of developmental mechanisms, including cell proliferation, cell differentiation, cell-cell recognition, neurite outgrowth and synaptogenesis. we cloned 16 novel members of the classic cadherin and delta-protocadherin subgroups from ferret brain. their expression patterns were investigated by in situ hybridization in the developing primary visual cortex (v1) of th ... | 2009 | 18534988 |
| long-lasting anti-emetic effect of t-2328, a novel nk(1) antagonist. | the effect of t-2328 {2-fluoro-4'-methoxy-3'-[[[(2s,3s)-2-phenyl-3-piperidinyl]amino]methyl]-[1,1'-biphenyl]-4-carbonitrile dihydrochloride}, a novel tachykinin nk(1)-receptor antagonist, was examined on cisplatin-induced emesis in ferrets. cisplatin induced acute emesis in 24 h and delayed emesis during 24 and 72 h, respectively. ondansetron, a 5-ht(3) antagonist, almost completely blocked the acute emesis and transiently reduced the delayed emesis. in contrast, t-2328 elicited long-lasting ant ... | 2008 | 18544900 |
| an unusual presentation of canine distemper virus infection in a domestic ferret (mustela putorius furo). | a 4.5-year-old, male castrated ferret was examined with a 27-day history of severe pruritus, generalized erythema and scaling. skin scrapings and a trichogram were negative for mites and dermatophyte organisms. a fungal culture of hair samples was negative. the ferret was treated presumptively for scabies and secondary bacterial and yeast infection with selamectin, enrofloxacin, fluconazole, diphenhydramine and a miconazole-chlorhexidine shampoo. the ferret showed mild improvement in clinical si ... | 2008 | 18547381 |
| the development of intrinsic excitability in mouse retinal ganglion cells. | activity-dependent refinement of synaptic connections occurs throughout the developing nervous system, including the visual system. retinal ganglion cells (rgcs) overproduce synapses then refine them in an activity-dependent manner that segregates rgc connections into multicellular patterns, such as eye-specific regions and retinotopic maps. ferrets additionally segregate on and off retinogeniculate pathways in an activity-dependent manner. it was unknown whether differences in on versus off int ... | 2008 | 18548483 |
| pharmacokinetics and brain penetration of casopitant, a potent and selective neurokinin-1 receptor antagonist, in the ferret. | the pharmacokinetics and brain penetration of the novel neurokinin (nk)-1 receptor antagonist casopitant [1-piperidinecarboxamide, 4-(4-acetyl-1-piperazinyl)-n-((1r)-1-(3,5-bis(trifluoromethyl)phenyl)ethyl)-2-(4-fluoro-2-methylphenyl)-n-methyl-, (2r,4s)-; gw679769] were examined in ferrets. the ferret is known to respond to the full spectrum of agents recognized to induce emesis in humans, and the cisplatin-induced emesis models in the ferret have been used to establish the antiemetic potential ... | 2008 | 18556439 |
| tuned responses of astrocytes and their influence on hemodynamic signals in the visual cortex. | astrocytes have long been thought to act as a support network for neurons, with little role in information representation or processing. we used two-photon imaging of calcium signals in the ferret visual cortex in vivo to discover that astrocytes, like neurons, respond to visual stimuli, with distinct spatial receptive fields and sharp tuning to visual stimulus features including orientation and spatial frequency. the stimulus-feature preferences of astrocytes were exquisitely mapped across the ... | 2008 | 18566287 |
| acute and chronic effects of ferret odor exposure in sprague-dawley rats. | this manuscript describes several behavioral and functional studies evaluating the capacity of ferret odors to elicit a number of acute and long-term responses in male sprague-dawley rats. acute presentation elicits multiple responses, suggesting that ferret odor, likely from skin gland secretions, provides an anxiogenic-like stimulus in this strain of rats. compared to cat odor, however, ferret odor did not produce rapid fear conditioning, a result perhaps attributable to methodological factors ... | 2008 | 18573530 |
| heterosubtypic protection against pathogenic human and avian influenza viruses via in vivo electroporation of synthetic consensus dna antigens. | the persistent evolution of highly pathogenic avian influenza (hpai) highlights the need for novel vaccination techniques that can quickly and effectively respond to emerging viral threats. we evaluated the use of optimized consensus influenza antigens to provide broad protection against divergent strains of h5n1 influenza in three animal models of mice, ferrets, and non-human primates. we also evaluated the use of in vivo electroporation to deliver these vaccines to overcome the immunogenicity ... | 2008 | 18575608 |
| a live attenuated cold-adapted influenza a h7n3 virus vaccine provides protection against homologous and heterologous h7 viruses in mice and ferrets. | the appearance of human infections caused by avian influenza a h7 subtype viruses underscores their pandemic potential and the need to develop vaccines to protect humans from viruses of this subtype. a live attenuated h7n3 virus vaccine was generated by reverse genetics using the ha and na genes of a low pathogenicity a/chicken/bc/cn-6/04 (h7n3) virus and the six internal protein genes of the cold-adapted a/ann arbor/6/60 ca (h2n2) virus. the reassortant h7n3 bc 04 ca vaccine virus was temperatu ... | 2008 | 18585748 |
| cytochrome b5 expression in gonadectomy-induced adrenocortical neoplasms of the domestic ferret (mustela putorius furo). | whereas the adrenal glands of healthy ferrets produce only limited amounts of androgenic steroids, adrenocortical neoplasms that arise in neutered ferrets typically secrete androgens or their derivative, estrogen. the 17,20-lyase activity of cytochrome p450 17alpha-hydroxylase/17,20-lyase (p450c17) must increase to permit androgen biosynthesis in neoplastic adrenal tissue. we screened ferret adrenocortical tumor specimens for expression of cytochrome b(5) (cyt b(5)), an allosteric regulator that ... | 2008 | 18587089 |
| pathology of experimental sars coronavirus infection in cats and ferrets. | the pathology of severe acute respiratory syndrome-coronavirus (sars-cov) infection in cats and ferrets is poorly described, and the distribution of angiotensin-converting enzyme 2 (ace2), a receptor for sars-cov, in the respiratory tracts of these species is unknown. we observed sars-cov antigen expression and lesions in the respiratory tracts of 4 cats and 4 ferrets at 4 days postinoculation and ace2 expression in the respiratory tracts of 3 cats and 3 ferrets without infection. all infected c ... | 2008 | 18587105 |
| p2x(3) expression is not altered by lingual nerve injury. | we have investigated a possible role for the atp receptor subunit p2x(3), in the development of neuropathic pain following injury to a peripheral branch of the trigeminal nerve. in nine anaesthetised adult ferrets the left lingual nerve was sectioned and recovery permitted for 3 days, 3 weeks or 3 months (3 ferrets per group). a retrograde tracer, fluorogold, was applied to the nerve to allow identification of cell bodies in the trigeminal ganglion with axons in the injured nerve. indirect immun ... | 2008 | 18597934 |
| treatment of influenza a (h1n1) virus infections in mice and ferrets with cyanovirin-n. | cyanovirin-n (cv-n), a protein derived from nostoc ellipsosporum, neutralizes influenza virus infectivity by binding to specific high-mannose oligosaccharides (oligomannose-8 and -9) at glycosylation sites on the viral hemagglutinin ha1 subunit. mouse-adapted viruses lose sensitivity to cv-n due to ha1 mutations that eliminate these glycosylation sites. recently we created a hybrid (reassortant) influenza a/wsn/33 (h1n1) virus containing the ha gene of a/new caledonia/20/99 (h1n1) with an asp225 ... | 2008 | 18601954 |
| effect of amiodarone on kv1.4 channel c-type inactivation: comparison of its effects with those induced by propafenone and verapamil. | as the major component of i(to) (slow), kv1.4 channel plays an important role in repolarization of cardiac myocytes. c-type inactivation is one of kv1.4 inactivation and can be affected by open channel blockers. we used the two-electrode voltage clamp technique to observe the effect of amiodarone on kv1.4 c-type inactivation and compare amiodarone's effects on kv1.4 with propafenone and verapamil. our data show that those three antiarrhythmic drugs blocked fkv1.4 delta n (n-terminal deleted kv1. ... | 2008 | 18604993 |
| domestic pigs have low susceptibility to h5n1 highly pathogenic avian influenza viruses. | genetic reassortment of h5n1 highly pathogenic avian influenza viruses (hpai) with currently circulating human influenza a strains is one possibility that could lead to efficient human-to-human transmissibility. domestic pigs which are susceptible to infection with both human and avian influenza a viruses are one of the natural hosts where such reassortment events could occur. virological, histological and serological features of h5n1 virus infection in pigs were characterized in this study. two ... | 2008 | 18617994 |
| mechanism of the prostanoid tp receptor agonist u46619 for inducing emesis in the ferret. | u46619 is a potent thromboxane a(2) mimetic with emesis-inducing actions that are mediated via prostanoid tp receptors. we investigated its emetic mechanism of action in more detail using the ferret as model animal. the emesis induced by u46619 (30 microg/kg, intraperitoneal) was antagonized significantly by (+)-(2s,3s)-3-(2-methoxybenzylamino)-2-phenylpiperidine hydrochloride (cp-99,994; 1 and 10 mg/kg; p < 0.05) and metoclopramide (0.3 and 3 mg/kg), but not by domperidone (3 mg/kg), sulpiride ... | 2008 | 18618098 |
| molecular cloning and phylogenetic analysis of inflammatory cytokines of the ferret (mustela putorius furo). | the present study determined the cdna and deduced amino acid sequences of ferret (mustela putorius furo) inflammatory cytokines, interferon (ifn)-gamma, interleukin (il)-1beta, il-6, il-8 and tumor necrosis factor (tnf)-alpha. the homologies of the nucleotide sequences of ifn-gamma, il-1beta, il-6, il-8 and tnf-alpha of the ferret to those from other mammalian species ranged from 64.3-92.9%, 73.0-83.9, 58.1-84.8%, 58.1-89.7% and 79.0-95.0%, respectively. as distinctive amino acid residues consti ... | 2008 | 18628593 |
| non-linear population firing rates and voltage sensitive dye signals in visual areas 17 and 18 to short duration stimuli. | visual stimuli of short duration seem to persist longer after the stimulus offset than stimuli of longer duration. this visual persistence must have a physiological explanation. in ferrets exposed to stimuli of different durations we measured the relative changes in the membrane potentials with a voltage sensitive dye and the action potentials of populations of neurons in the upper layers of areas 17 and 18. for durations less than 100 ms, the timing and amplitude of the firing and membrane pote ... | 2008 | 18628825 |
| localised radiotherapy for a ferret with possible anal sac apocrine adenocarcinoma. | a seven-year-old, neutered male ferret was referred to our hospital with two perianal masses (2.4x3.0 and 2.4x3.5 cm, respectively) that had recurred after initial surgical excision. complete resection of the masses was impossible as there was deep invasion along the rectum. on histopathology, the masses were diagnosed as apocrine adenocarcinoma possibly of anal gland origin based on tumour location. there was marked response to localised radiotherapy using an orthovoltage unit at 4 gy, twice we ... | 2008 | 18631226 |
| isolation of mycobacterium bovis and other mycobacterial species from ferrets and stoats. | as part of wildlife surveillance for bovine tuberculosis, pooled lymph nodes from 21,481 ferrets, 1056 stoats and 83 weasels were cultured for mycobacteria. a total of 268 isolates of mycobacterium bovis were obtained from ferrets, 2 from stoats and none from weasels, demonstrating the presence of a wildlife reservoir of infection in ferrets. dna typing by restriction endonuclease analysis (rea) of 48 selected isolates of m. bovis revealed 23 rea types. twenty-one of these types had previously b ... | 2008 | 18632227 |
| efficient term development of vitrified ferret embryos using a novel pipette chamber technique. | development of an efficient cryopreservation technique for the domestic ferret is key for the long-term maintenance of valuable genetic specimens of this species and for the conservation of related endangered species. unfortunately, current cryopreservation procedures, such as slow-rate freezing and vitrification with open pulled straws, are inefficient. in this report, we describe a pipette tip-based vitrification method that significantly improves the development of thawed ferret embryos follo ... | 2008 | 18633142 |
| a case of fibrosarcoma on the perivertebral surface of a ferret with hind limb paralysis. | a 2.5 year-old female ferret had a stiff palpable mass arising from the dorsal surface of the thoracic (t) to lumbar (l) vertebrae with paralysis of the hind limbs. by myelography the dorsal and ventral lines of contrast were not observed in the area forwarded of l3. grossly, the tumor encircled the dorsal vertebrae. microscopically, tumor cells were proliferated intimately and were attached to the vertebrae surface involving surrounding fatty and connective tissues. the tumor consisted of fibro ... | 2008 | 18633162 |
| effect of sb-750364, a specific trpv1 receptor antagonist, on injury-induced ectopic discharge in the lingual nerve. | abnormal neural activity generated at a site of nerve injury is thought to contribute to the development of dysaesthesia. vanilloid receptor 1 (trpv1), a transducer of noxious stimuli, may be involved in the initiation of this abnormal activity and could provide a useful therapeutic target. we investigated the effect of a specific trpv1 antagonist (sb-750364) on injury-induced discharge in the lingual nerve. in 12 anaesthetised adult ferrets the left lingual nerve was sectioned and animals were ... | 2008 | 18634850 |
| reproduction of the female ferret (mustela putorius furo). | the domestic ferret is a seasonally polyoestrous species. females reach puberty at the age of 8-12 months. females exhibit a constant oestrus between late march and early august if they are not bred. increasing tumescence in the pink-coloured vulva is a sign of pro-oestrus. oestrus can persist for up to 5 months, but once ovulation is induced, either pregnancy or pseudopregnancy ensues. follicular development and atresia overlap in such a manner that there is a recent cohort of follicles availab ... | 2008 | 18638117 |
| discovery and stereoselective synthesis of the novel isochroman neurokinin-1 receptor antagonist 'cj-17,493'. | a novel central nervous system (cns) selective neurokinin-1 (nk(1)) receptor antagonist, (2s,3s)-3-[(1r)-6-methoxy-1-methyl-1-trifluoromethylisochroman-7-yl]-methylamino-2-phenylpiperidine 'cj-17,493' (compound (+)-1), was synthesized stereoselectively using a kinetic resolution by lipase-ps as a key step. compound (+)-1 displayed high and selective affinity (k(i)=0.2 nm) for the human nk(1) receptor in im-9 cells, potent activity in the [sar(9), met(o(2))(11)]sp-induced gerbil tapping model (ed ... | 2008 | 18640044 |
| intrinsic effects of am4113, a putative neutral cb1 receptor selective antagonist, on open-field behaviors in rats. | we examined open-field effects in rats of the cannabinoid 1 receptor (cb1r) agonist win55,212-2 (win; 3 mg/kg) and its interaction with the cb1r putative neutral antagonist am4113 (0.3 to 3 mg/kg). separate studies examined am4113 alone (0.3 to 5.6 mg/kg). unlike the cb1r antagonist rimonabant, in vitro (e.g., [sink k.s., mclaughlin p.j., wood j.a., brown c., fan p., vemuri v.k., pang y., olzewska t., thakur g.a., makriyannis a., parker l.a., salamone j.d. the novel cannabinoid cb(1) receptor ne ... | 2008 | 18640150 |
| death as a study endpoint: why use ferrets? | 2008 | 18650819 | |
| animal models in influenza vaccine testing. | the threat of a pandemic outbreak of influenza a h5n1 and h2n2 has brought attention to the development of new vaccines. regulatory authorities require companies to provide data proving the effectiveness of vaccines, which cannot, however, be based on real efficacy data in humans. a weight-of-evidence approach may be used, based on evidence of protection in an appropriate animal model and the satisfaction of the surrogate end points in the clinical situation. in this review, we will discuss vari ... | 2008 | 18665776 |
| natural infection with two genotypes of cryptosporidium in red squirrels (sciurus vulgaris) in italy. | we investigated the genotypes of cryptosporidium infecting red squirrels (sciurus vulgaris l.) in two areas of the western alps in italy. examination of 141 faecal samples from 70 red squirrels revealed oocysts of cryptosporidium in 17 animals (24.3%). based on 18s rrna gene sequencing, two genotypes of cryptosporidium species were found: 15 squirrels were positive for the cryptosporidium ferret genotype and 2 for the cryptosporidium chipmunk genotype i. the occurrence and intensity of cryptospo ... | 2008 | 18666411 |
| action of (r)-sila-venlafaxine and reboxetine to antagonize cisplatin-induced acute and delayed emesis in the ferret. | the chemotherapeutic drug cisplatin is associated with severe gastrointestinal toxicity that can last for several days. a recent strategy to treat the nausea and emesis includes the combination of a 5-ht3 receptor antagonist, a glucocorticoid, and an nk1 receptor antagonist. the present studies explore the use of the selective noradrenaline reuptake inhibitors, (r)-sila-venlafaxine, (r,r)-reboxetine and (s,s)-reboxetine to prevent cisplatin (5 mg/kg, i.p.)-induced acute (0-24 h) and delayed (24- ... | 2008 | 18675289 |
| an overview of restraint and blood collection techniques in exotic pet practice. | as more data about blood test results become available, blood sampling becomes increasingly important as a diagnostic tool. the increased availability of biochemistry analyzers that sample small volumes of blood has made it possible to get diagnostic profiles and hematology results from pets that have only small volumes of blood to contribute. this article describes techniques for restraint, phlebotomy, and sample preparation of several of the more popular exotic animals in the pet trade. the sp ... | 2008 | 18675727 |
| ferret hematology and related disorders. | this article summarizes the general topic of ferret hematology, including discussion of restraint for phlebotomy and phlebotomy sites, red and white blood cell morphology, interpretation of the hemogram, and normal and abnormal factors affecting the hemogram. in addition, the apparent lack of blood groups and techniques for bone marrow aspirates and blood transfusion are addressed. there is much still to be learned about the ferret and its diseases. we often depend on tests as simple as the comp ... | 2008 | 18675733 |
| docosahexaenoic acid induces apoptosis in lung cancer cells by increasing mkp-1 and down-regulating p-erk1/2 and p-p38 expression. | different agents able to modulate apoptosis have been shown to modify the expression of the map-kinase-phosphatase-1 (mkp-1). the expression of this phosphatase has been considered a potential positive prognostic factor in lung cancer, and smoke was shown to reduce the levels of mkp-1 in ferret lung. our aim was to assess whether the n-3 polyunsaturated fatty acid docosahexaenoic acid (dha), known to inhibit the growth of several cancer cells mainly inducing apoptosis, may exert pro-apoptotic ef ... | 2008 | 18679798 |
| oseltamivir-resistant influenza a viruses are transmitted efficiently among guinea pigs by direct contact but not by aerosol. | influenza viruses resistant to the neuraminidase (na) inhibitor oseltamivir arise under drug selection pressure both in vitro and in vivo. several mutations in the active site of the viral na are known to confer relative resistance to oseltamivir, and influenza viruses with certain oseltamivir resistance mutations have been shown to transmit efficiently among cocaged ferrets. however, it is not known whether na mutations alter aerosol transmission of drug-resistant influenza virus. here, we demo ... | 2008 | 18684820 |
| gene expression analysis of host innate immune responses during lethal h5n1 infection in ferrets. | how viral and host factors contribute to the severe pathogenicity of the h5n1 subtype of avian influenza virus infection in humans is poorly understood. we identified three clusters of differentially expressed innate immune response genes in lungs from h5n1 (a/vietnam/1203/04) influenza virus-infected ferrets by oligonucleotide microarray analysis. interferon response genes were more strongly expressed in h5n1-infected ferret lungs than in lungs from ferrets infected with the less pathogenic h3n ... | 2008 | 18684821 |
| use of a slam transfected vero cell line to isolate and characterize marine mammal morbilliviruses using an experimental ferret model. | two ferrets (mustela putorius furo) were experimentally infected with phocine distemper virus (pdv), from the 1988 seal epizootic in europe, in order to determine whether the stable transfected vero cell line (vero.dogslamtag) expressing canine "signaling lymphocyte activation molecules" (slam; cd150) receptors, was more suitable for isolating and characterizing pdv when compared with vero (american type culture collection # c1008) and primary seal kidney (psk) cells. both ferrets displayed char ... | 2008 | 18689645 |
| heterogeneous expression of no-activated soluble guanylyl cyclase in mammalian heart: implications for no- and redox-mediated indirect versus direct regulation of cardiac ion channel function. | nitrogen oxides exert significant but diverse regulatory effects on cardiac myocytes. many of these effects are due to modulation of voltage-sensitive ion channel function. the redox-status of no-related compounds is a critical factor in determining whether indirect (cgmp-dependent) versus direct (cgmp-independent) effects are dominant. however, molecular mechanisms by which different cardiac myocyte types, and associated different ion channel types expressed within them, could achieve selectivi ... | 2007 | 18690042 |
| a ferret-based gastrointestinal image retrieval system. | we developed a web-based interface for image retrieval and cluster analysis system. the system handles search queries using ferret, a port to the ruby language of the apache lucene indexing and searching system. the system uses de-identified endoscopic images from the clinical outcomes research initiative data repository, and is designed for use by students and researchers. | 2007 | 18693969 |
| replication and transmission of h9n2 influenza viruses in ferrets: evaluation of pandemic potential. | h9n2 avian influenza a viruses are endemic in poultry of many eurasian countries and have caused repeated human infections in asia since 1998. to evaluate the potential threat of h9n2 viruses to humans, we investigated the replication and transmission efficiency of h9n2 viruses in the ferret model. five wild-type (wt) h9n2 viruses, isolated from different avian species from 1988 through 2003, were tested in vivo and found to replicate in ferrets. however these viruses achieved mild peak viral ti ... | 2008 | 18698430 |
| h5n1 vlp vaccine induced protection in ferrets against lethal challenge with highly pathogenic h5n1 influenza viruses. | in this study, recombinant virus-like particles (vlps) were evaluated as a candidate vaccine against emerging influenza viruses with pandemic potential. the vlps are composed of the hemagglutinin (ha), neuraminidase (na), and matrix 1 (m1) proteins of the h5n1 a/indonesia/05/2005 (clade 2.1; [indo/05]) virus, which were expressed using baculovirus in spodoptera frugiperda (sf9) cells. ferrets received either 2 injections of the vlp vaccine at escalating doses (based on ha content), recombinant h ... | 2008 | 18706956 |
| live, attenuated influenza virus (laiv) vehicles are strong inducers of immunity toward influenza b virus. | historically, vaccines developed toward influenza viruses of the b type using methodologies developed for influenza a viruses as a blueprint have not been equally efficacious or effective. because most influenza research and public attention concerns influenza a viruses, these shortcomings have not been adequately addressed. in this manuscript, we utilized different influenza vaccine vehicles to compare immunogenicity and protection in mice and ferrets after vaccination against an influenza b vi ... | 2008 | 18708106 |
| avian influenza h6 viruses productively infect and cause illness in mice and ferrets. | influenza pandemic preparedness has focused on influenza virus h5 and h7 subtypes. however, it is not possible to predict with certainty which subtype of avian influenza virus will cause the next pandemic, and it is prudent to include other avian influenza virus subtypes in pandemic preparedness efforts. an h6 influenza virus was identified as a potential progenitor of the h5n1 viruses that emerged in hong kong in 1997. this virus continues to circulate in the bird population in asia, and other ... | 2008 | 18715930 |
| interleukin (il)-1 regulates ozone-enhanced tracheal smooth muscle responsiveness by increasing substance p (sp) production in intrinsic airway neurons of ferret. | exposure to ozone induces airway hyperresponsiveness (ahr) mediated partly by substance p (sp) released from nerve terminals of intrinsic airway neurons. our recent studies showed that interleukin (il)-1, an important multifunctional proinflammatory cytokine, increases synthesis and release of sp from intrinsic airway neurons. the purpose of this study is to investigate the possible involvement of endogenous il-1 in modulating neural responses associated with ozone-enhanced airway responsiveness ... | 2008 | 18718561 |
| outbreak of canine distemper in domestic ferrets (mustela putorius furo). | in 2006 an outbreak of canine distemper affected 14 young domestic ferrets in barcelona, spain. their clinical signs included a reduced appetite, lethargy, dyspnoea, coughing, sneezing, mucopurulent ocular and nasal discharges, facial and perineal dermatitis, diarrhoea, splenomegaly and fever. late in the course of the disease, general desquamation and pruritus, and hyperkeratotic/crusting dermatitis of the lips, eyes, nose, footpads, and perineal area were observed. none of the ferrets develope ... | 2008 | 18723866 |
| laboratory findings, histopathology, and immunophenotype of lymphoma in domestic ferrets. | lymphoma is a common tumor in ferrets, but anatomic distribution, histomorphology, immunophenotype, laboratory abnormalities, and response to chemotherapy are incompletely defined. in this study, lymphoma was diagnosed by histopathology of tumor tissue in 29 ferrets ranging in age from 0.8 to 8.5 years, including 12 males and 17 females. tumors involved the viscera of the abdominal cavity (n = 11), thoracic cavity (n = 1), or abdominal and thoracic cavities (n = 7); the skin (n = 2); or the visc ... | 2008 | 18725471 |
| sensitivity to relative disparity in early visual cortex of pigmented and albino ferrets. | to investigate binocular interactions as the neuronal substrate for disparity sensitivity in the ferret (mustela putorius furo), we measured the effects of relative horizontal disparities on responses of neurons in areas 17 and 18 of the visual cortex. stimulation by moving bars and sinusoidal gratings showed that about half of our sample in pigmented ferrets was sensitive to relative horizontal disparity. this also included many neurons, which were classified as only monocularly activated when ... | 2009 | 18726091 |
| severe acute respiratory syndrome vaccine efficacy in ferrets: whole killed virus and adenovirus-vectored vaccines. | although the 2003 severe acute respiratory syndrome (sars) outbreak was controlled, repeated transmission of sars coronavirus (cov) over several years makes the development of a sars vaccine desirable. we performed a comparative evaluation of two sars vaccines for their ability to protect against live sars-cov intranasal challenge in ferrets. both the whole killed sars-cov vaccine (with and without alum) and adenovirus-based vectors encoding the nucleocapsid (n) and spike (s) protein induced neu ... | 2008 | 18753223 |
| coagulation values in normal ferrets (mustela putorius furo) using selected methods and reagents. | accurate determination of commonly measured coagulation values would be useful in the diagnosis and management of coagulopathies in domestic ferrets (mustela putorius furo). we are unaware of reports of coagulation times in this species. | 2008 | 18761520 |
| comments on treatment of hyperadrenocorticism in ferrets. | 2008 | 18764701 | |
| a case of coccygeal chondroid chordoma in a cat: morphological and immunohistochemical features. | in august 2007, a 4-year-old, intact, female domestic shorthair cat was examined for a mass on the tip of the tail. histological examination performed after apical caudectomy revealed a neoplasm affecting the distal part of the last coccygeal vertebra. the neoplasm consisted of lobules of physaliferous cells surrounding cartilaginous tissue and a central core of trabecular bone. a diagnosis of chondroid chordoma was made based on histomorphological features and immunohistochemical results. chond ... | 2008 | 18776111 |
| mixed urolith (struvite and calcium oxalate) in a ferret (mustela putorius furo). | urolithiasis has been reported in veterinary literature in some species of the mustelidae family, including ferrets. in this species, the most common form of urolithiasis is that caused by struvite. the current study examined the case of mixed urolith in an 8-month-old female ferret (mustela putorius furo) with antecedents of strangury and hematuria. a cystotomy was carried out to remove the urolith, which had a rough surface and a homogeneously porous interior and was formed by a mixture of str ... | 2008 | 18776112 |
| complementary roles of the main and accessory olfactory systems in mammalian mate recognition. | we review studies conducted in mouse and ferret that have specified roles of both the main and the accessory olfactory nervous systems in the detection and processing of body odorants (e.g., urinary pheromones, extraorbital lacrimal gland secretions, major histocompatibility complex peptide ligands, and anal scent gland secretions) that play an essential role in sex discrimination and attraction between males and females leading to mate choice and successful reproduction. we also review literatu ... | 2009 | 18817511 |
| cytomorphological and immunohistochemical features of lymphoma in ferrets. | twenty ferrets with histopathologically diagnosed lymphoma were classified cytomorphologically and immunohistochemically. according to site of origin, multicentric, gastrointestinal, mediastinal and cutaneous lymphomas accounted for 8 (40%), 9 (45%), 2 (10%) and 1 case (5%), respectively. according to the national cancer institute working formulation (nci-wf), low-, high- and intermediate-grade lymphomas accounted for 4 (20%), 4 (20%) and 12 cases (60%), respectively. the 4 low-grade lymphomas s ... | 2008 | 18840962 |
| repeated ferret odor exposure induces different temporal patterns of same-stressor habituation and novel-stressor sensitization in both hypothalamic-pituitary-adrenal axis activity and forebrain c-fos expression in the rat. | repeated exposure to a moderately intense stressor typically produces attenuation of the hypothalamic-pituitary-adrenal (hpa) axis response (habituation) on re-presentation of the same stressor; however, if a novel stressor is presented to the same animals, the hpa axis response may be augmented (sensitization). the extent to which this adaptation is also evident within neural activity patterns is unknown. this study tested whether repeated ferret odor (fo) exposure, a moderately intense psychol ... | 2009 | 18845631 |
| segregated hemispheric pathways through the optic chiasm distinguish primates from rodents. | at the optic chiasm retinal fibers either cross the midline, or remain uncrossed. here we trace hemispheric pathways through the marmoset chiasm and show that fibers from the lateral optic nerve pass directly toward the ipsilateral optic tract without any significant change in fiber order and without approaching the midline, while those from medial regions of the nerve decussate directly. anterograde labeling from one eye shows that the two hemispheric pathways remain segregated through the prox ... | 2008 | 18854206 |
| comparative analysis of cadherin expression and connectivity patterns in the cerebellar system of ferret and mouse. | the cerebellum shows remarkable variations in the relative size of its divisions among vertebrate species. in the present study, we compare the cerebella of two mammals (ferret and mouse) by mapping the expression of three cadherins (cadherin-8, protocadherin-7, and protocadherin-10) at similar postnatal stages. the three cadherins are expressed differentially in parasagittal stripes in the cerebellar cortex, in the portions of the deep cerebellar nuclei, in the divisions of the inferior olivary ... | 2008 | 18855899 |
| an epizootic in influenza in a ferret colony. | 1948 | 18887763 | |
| the isolation of salmonella typhi-murium from ferrets. | 1948 | 18902265 | |
| epibatidine application in vitro blocks retinal waves without silencing all retinal ganglion cell action potentials in developing retina of the mouse and ferret. | epibatidine (epi), a potent cholinergic agonist, disrupts acetylcholine-dependent spontaneous retinal activity. early patch-clamp recordings in juvenile ferrets suggested that epi blocks all retinal ganglion cell (rgc) action potentials when applied to the retina. in contrast, recent experiments on the developing mouse that relied on multielectrode array (mea) recordings reported that epi application decorrelates the activity of neighboring rgcs and eliminates retinal waves while preserving the ... | 2008 | 18922954 |
| effects of ovariectomy and aging on tooth attachment in female mice assessed by morphometric analysis. | non-human primates, dogs, rats, hamsters and ferrets, have frequently been used as laboratory animals in periodontal biology and pathology. in the past, mice have been used less for this purpose, but nowadays attract a lot of interest because gene knockout and transgenic technologies utilize mice primarily. in this study, we investigate the effects of ovariectomy and aging on tooth attachment in female mice. | 2009 | 18923970 |
| new insights in the neural regulation of the lower oesophageal sphincter. | gastro-oesophageal reflux disease (gord) is caused by disordered control of the gastro-oesophageal reflux barrier, comprised internally of the lower oesophageal sphincter (los) and externally the crural diaphragm (cd). both relax briefly to allow bolus passage during oesophageal peristalsis. brief relaxation also occurs prior to gastro-oesophageal reflux, known as transient los relaxation (tlosr), normally allowing venting of gas. tlosrs also account for up to 90% of acid reflux episodes. the de ... | 2008 | 18924442 |
| simple and complex spike firing patterns in purkinje cells during classical conditioning. | classical blink conditioning is known to depend critically on the cerebellum and the relevant circuitry is gradually being unravelled. several lines of evidence support the theory that the conditioned stimulus is transmitted by mossy fibers to the cerebellar cortex whereas the unconditioned stimulus is transmitted by climbing fibers. this view has been dramatically confirmed by recent purkinje cell recordings during training with a classical conditioning paradigm. we have tracked the activity of ... | 2008 | 18931885 |
| evaluation of live attenuated influenza a virus h6 vaccines in mice and ferrets. | avian influenza a virus a/teal/hk/w312/97 (h6n1) possesses seven gene segments that are highly homologous to those of highly pathogenic human influenza h5n1 viruses, suggesting that a w312-like h6n1 virus might have been involved in the generation of the a/hk/97 h5n1 viruses. the continuous circulation and reassortment of influenza h6 subtype viruses in birds highlight the need to develop an h6 vaccine to prevent potential influenza pandemics caused by the h6 viruses. based on the serum antibody ... | 2009 | 18945773 |
| experience with moving visual stimuli drives the early development of cortical direction selectivity. | the onset of vision occurs when neural circuits in the visual cortex are immature, lacking both the full complement of connections and the response selectivity that defines functional maturity. direction-selective responses are particularly vulnerable to the effects of early visual deprivation, but it remains unclear how stimulus-driven neural activity guides the emergence of cortical direction selectivity. here we report observations from a motion training protocol that allowed us to monitor th ... | 2008 | 18946471 |
| brainstem sites controlling the lower esophageal sphincter and crural diaphragm in the ferret: a neuroanatomical study. | the lower esophageal sphincter (les) and the crural diaphragm (cd) surrounding the esophagogastric junction are key components of the gastroesophageal reflex mechanism, which engages the vago-vagal brainstem circuitry. although both components work in conjunction to prevent gastroesophageal reflux, little is known about the brain area(s) where this integration takes place. the aims of this study were to: (1) trace the brainstem circuitry associated with the cd and the les, and (2) determine poss ... | 2008 | 18986853 |
| virtual adult ears reveal the roles of acoustical factors and experience in auditory space map development. | auditory neurons in the superior colliculus (sc) respond preferentially to sounds from restricted directions to form a map of auditory space. the development of this representation is shaped by sensory experience, but little is known about the relative contribution of peripheral and central factors to the emergence of adult responses. by recording from the sc of anesthetized ferrets at different age points, we show that the map matures gradually after birth; the spatial receptive fields (srfs) b ... | 2008 | 18987192 |
| chromatin configurations in the ferret germinal vesicle that reflect developmental competence for in vitro maturation. | in several mammalian species, the configuration of germinal vesicle (gv) chromatin correlates with the developmental competence of oocytes. yet, no study has been published on the configuration of gv chromatin in ferret, nor is it known whether a specific configuration predicts meiotic competence in this species, in spite of the potential importance of ferret cloning to the study of human disease and to species conservation efforts. here, we report on an analysis of the chromatin configuration i ... | 2009 | 18992097 |
| minimal hodgkin-huxley type models for different classes of cortical and thalamic neurons. | we review here the development of hodgkin-huxley (hh) type models of cerebral cortex and thalamic neurons for network simulations. the intrinsic electrophysiological properties of cortical neurons were analyzed from several preparations, and we selected the four most prominent electrophysiological classes of neurons. these four classes are "fast spiking", "regular spiking", "intrinsically bursting" and "low-threshold spike" cells. for each class, we fit "minimal" hh type models to experimental d ... | 2008 | 19011929 |
| rapid modifications in calretinin immunostaining in the deep layers of the superior colliculus after unilateral cochlear ablation. | calretinin (cr) is a calcium-binding protein that plays an important role in the homeostasis of intracellular calcium concentration in the auditory pathway. to test if hearing loss could lead indirectly to modifications in levels of this calcium-binding protein in neurons and neuropilar structures outside of the lemniscal auditory pathway, cr-immunostaining was evaluated in the superior colliculus (sc) in adult ferrets at 1, 20 and 90 days after unilateral cochlear ablation. the results demonstr ... | 2009 | 19017539 |
| influenza-pseudotyped gag virus-like particle vaccines provide broad protection against highly pathogenic avian influenza challenge. | influenza-pseudotyped gag virus-like particles (vlps) were produced via the expression of influenza hemagglutinin (ha), neuraminidase (na) and the murine leukemia virus gag product in the baculovirus-insect cell expression system. hemagglutination specific activities of sucrose gradient-purified vlps were similar to those of egg-grown influenza viruses but particle morphologies were gamma retrovirus-like in the form of consistent 100nm spheres. immunization of mice and ferrets demonstrated robus ... | 2009 | 19026705 |
| what is your diagnosis? preputial mass in a ferret. | : a 7-year-old neutered male polecat-type ferret (mustela putorius furo) was presented for evaluation of a cutaneous mass close to the preputial orifice. cytologic examination of a fine-needle aspirate revealed numerous large clumps of amorphous pink mucinous material and numerous large clumps of slightly pleomorphic epithelial cells. the cells were arranged in papillary structures, palisades, and loosely cohesive sheets with a vaguely honeycomb appearance. occasional acinar formations were also ... | 2008 | 19055582 |
| stimulus-timing-dependent plasticity of cortical frequency representation. | adult cortical circuits possess considerable plasticity, which can be induced by modifying their inputs. one mechanism proposed to underlie changes in neuronal responses is spike-timing-dependent plasticity (stdp), an up- or downregulation of synaptic efficacy contingent upon the order and timing of presynaptic and postsynaptic activity. the repetitive and asynchronous pairing of a sensory stimulus with either another sensory stimulus or current injection can alter the response properties of vis ... | 2008 | 19074036 |
| the surface electrocardiogram in domestic ferrets. | the two goals of the current study were to evaluate the surface electrocardiogram for significant differences observed between two different recumbency positions and suggest normal surface electrocardiographic values in those positions for the "clinically" normal domestic pet ferret (mustela putorius furo). | 2006 | 19083342 |
| developmental validation of a novel lateral flow strip test for rapid identification of human blood (rapid stain identification--blood). | human blood is the body fluid most commonly encountered at crime scenes, and blood detection may aid investigators in reconstructing what occurred during a crime. in addition, blood detection can help determine which items of evidence should be processed for dna-str testing. unfortunately, many common substances can cause red-brown stains that resemble blood. furthermore, many current human blood detection methods are presumptive and prone to false positive results. here, the developmental valid ... | 2008 | 19083828 |
| plant-derived hemagglutinin protects ferrets against challenge infection with the a/indonesia/05/05 strain of avian influenza. | the global spread of highly pathogenic avian influenza virus (h5n1 subtype) has promoted efforts to develop human vaccines against potential pandemic outbreaks. however, current platforms for influenza vaccine production are cumbersome, limited in scalability and often require the handling of live infectious virus. we describe the production of hemagglutinin from the a/indonesia/05/05 strain of h5n1 influenza virus by transient expression in plants, and demonstrate the immunogenicity and protect ... | 2009 | 19100806 |
| [curve-fits with hybrid logistic functions for isovolumic left ventricular pressure curve and isometric myocardial tension curve]. | non-linear regression and curve-fitting may contribute to resolution of the mechanism, summarise information, remove noise, allow speculation regarding unmeasured data, and separate the effects of multiple factors. the isovolumic left ventricular (lv) pressure curve and isometric myocardial tension curve have been curve-fit with polynomial expotential and sinusoidal functions. the isovolumic lv pressure curve and myocardial isometric tension curve are composed of contraction and relaxation proce ... | 2008 | 19108490 |
| pelvic limb lameness in a ferret. | 2009 | 19112443 |