Publications
| Title | Abstract | Year Filter | PMID(sorted ascending) Filter |
|---|
| development and characterization of a novel antiacne niosomal gel of rosmarinic acid. | the antibacterial and anti-inflammatory potential of rosemarinic acid (roa), a naturally occurring ester of caffeic acid has been well reported. antibacterial effect of roa is attributed to nucleoid damage with an increase in spatial division and condensation of genetic material. roa has been found dynamic against many human pathogenic bacterial strains but its inhibitory prospective has never been established against skin inflammations caused by propionibacterium acne. the skin surface in acne ... | 2015 | 24786487 |
| importance of kupffer cells in the development of acute liver injuries in mice. | kupffer cells reside within the liver sinusoid and serve as gatekeepers. they produce pro- and anti-inflammatory cytokines and other biologically important molecules upon the engagement of pattern recognition receptors such as toll-like receptors. kupffer cell-ablated mice established by in vivo treatment with clodronate liposomes have revealed many important features of kupffer cells. in this paper, we review the importance of kupffer cells in murine acute liver injuries and focus on the follow ... | 2014 | 24802875 |
| propionibacterium acnes activates the nlrp3 inflammasome in human sebocytes. | propionibacterium acne and sebaceous glands are considered to have an important role in the development of acne. although information regarding the activation of innate immunity by p. acnes in the sebaceous gland is limited, different p. acnes phylotypes and a higher prevalence of follicular p. acnes macrocolonies/biofilms in sebaceous follicles of skin biopsies from acne compared with control skin and occasionally single p. acnes clusters in single sebaceous glands have been detected. in this s ... | 2014 | 24820890 |
| hemolysis as a clinical marker for propionibacterium acnes orthopedic infection. | determining if a propionibacterium acnes culture is a true infection or a contaminant remains a challenge. we conducted a study to distinguish between a true infection and a contaminated culture based on the p acnes hemolytic phenotype and clinical presentation. all p acnes strains were from orthopedic patients who had undergone arthroplasty or nonarthroplasty shoulder procedures. hemolysis was determined according to p acnes growth on brucella blood agar plates after 48 to 72 hours. each patien ... | 2014 | 24839635 |
| current nanotechnological approaches for an effective delivery of bio-active drug molecules in the treatment of acne. | acne is a chronic inflammatory human skin disease, characterized by areas of skin with seborrhoea, comedones, papules, nodules, pimples, and possibly scarring with lesions occurring on face, neck, and back. nanotechnological approaches such as particulate (solid lipid nanoparticles and microspheres), vesicular (liposomes and niosomes), colloidal drug delivery systems (micro-emulsion and nano-emulsion), and miscellaneous systems (aerosol foams and micro-sponges) have an important place in acne th ... | 2016 | 24844191 |
| infectious prosthetic hip joint loosening: bacterial species involved in its aetiology and their antibiotic resistance profiles against antibiotics recommended for the therapy of implant-associated infections. | reliable microbiological diagnosis along with surgery and prolonged antibiotic therapy are key elements in the management of prosthetic-joint infections (pjis). the purpose of this study was to characterize antibiotic resistance profiles of bacteria involved in the aetiology of pjis. a total of 33 bacterial isolates cultured from 31 patients undergoing exchange of total hip prostheses were analyzed. the diagnostic approach toward isolation of prosthesis- associated microorganisms included sonica ... | 2014 | 24858648 |
| oral sarcoidosis: a case report and review of the literature. | sarcoidosis is a chronic multi-system immuno-inflammatory disorder characterized by non-caseating granulomatous infiltration of affected tissues that may result in fibrosis and organ dysfunction. it generally affects genetically predisposed young adults who develop a local dysregulated cell-mediated immune response towards an undefined 'sarcoidal antigen'. from recent data, it has become evident that propionibacterium acnes and mycobacterium tuberculosis are the probable antigenic agents which i ... | 2014 | 24862235 |
| management of late postoperative capsular block syndrome with accumulation of propionibacterium acnes. | 2014 | 24862790 | |
| yeast cell surface display of linoleic acid isomerase from propionibacterium acnes and its application for the production of trans-10, cis-12 conjugated linoleic acid. | conjugated linoleic acid (cla), a family of geometric and positional isomers of linoleic acid, has many health-promoting properties. different isomers of cla may have very different physiological effects. in the current work, we explore the possibility to produce single isomer of cla by using biocatalysis based on displayed biocatalysts on the yeast cell surfaces. a reporter system used to assess gene expression and protein distribution was established by combining the egfp gene to the n-terminu ... | 2015 | 24863409 |
| antimicrobial and anti-inflammatory activities of endophytic fungi talaromyces wortmannii extracts against acne-inducing bacteria. | acne vulgaris is the most common skin disease, causing significant psychosocial problems such as anxiety and depression similar to a chronic illness for those afflicted. currently, obtainable agents for acne treatment have limited use. thus, development of novel agents to treat this disease is a high medical need. the anaerobic bacterium propionibacterium acnes has been implicated in the inflammatory phase of acne vulgaris by activating pro-inflammatory mediators such as the interleukin-8 (il-8) ... | 2014 | 24887557 |
| novel pharmacological approaches for the treatment of acne vulgaris. | acne vulgaris is the most common skin disease worldwide; yet, current treatment options, although effective, are associated with unwanted side effects, chronicity, relapses and recurrences. the adequate control of the four pathogenic mechanisms, involved in the appearance of acne lesions, is paramount to treatment success. | 2014 | 24890096 |
| diagnosis and management of periprosthetic shoulder infections. | ➤ the unique bacterial flora of the shoulder present diagnostic and treatment challenges that are distinct from those seen with failed hip and knee arthroplasties.➤ the presentation, diagnosis, and management of suppurative periprosthetic joint infections of the shoulder are similar to those of the hip and the knee.➤ failed arthroplasties with positive cultures (fapcs) are poorly performing shoulder reconstructions associated with low-virulence microorganisms that do not evoke a suppurative infl ... | 2014 | 24897745 |
| toll-like receptor 2 and p. acnes: do they trigger initial acne vulgaris lesions? | to elucidate the role of toll-like receptor 2 (tlr2) in the pathogenesis of acne vulgaris through its immunohistochemical localization in inflammatory and noninflammatory lesions of this disease entity. | 2014 | 24902362 |
| intraspinal canal rod migration causing late-onset paraparesis 8 years after scoliosis surgery. | complete intraspinal canal rod migration with posterior bone reconstitution has never been described in the adolescent idiopathic scoliosis (ais) population. we present an unusual but significant delayed neurological complication after spinal instrumentation surgery. | 2016 | 24903395 |
| patient and procedure-specific risk factors for deep infection after primary shoulder arthroplasty. | deep infection after shoulder arthroplasty is a diagnostic and therapeutic challenge. the current literature on this topic is from single institutions or medicare samples, lacking generalizability to the larger shoulder arthroplasty population. | 2014 | 24906812 |
| systemic sarcoidosis with bone marrow involvement showing propionibacterium acnes in the lymph nodes. | 2015 | 24909186 | |
| isotretinoin therapy changes the expression of antimicrobial peptides in acne vulgaris. | in acne vulgaris, antimicrobial peptides (amps) could play a dual role; i.e., protective by acting against propionibacterium acnes, pro-inflammatory by acting as signalling molecules. the cutaneous expression of 15 different amps was investigated in acne patients; furthermore, the impact of isotretinoin therapy on amp expression was analysed in skin biopsies from 13 patients with acne vulgaris taken before, during and after a 6-month treatment cycle with isotretinoin using quantitative real-time ... | 2014 | 24916439 |
| re-evaluating treatment targets in acne vulgaris: adapting to a new understanding of pathophysiology. | two primary factors are changing current approaches to the management of acne vulgaris (av): the continuously evolving role of propionibacterium acnes in the pathophysiology of av and recent evidence of an inflammatory basis for av via innate immunity. the developing concepts emphasize that acne is primarily an inflammatory disease. the emerging concept of subclinical inflammation and its effect on development and progression of acne lesions correlating with the sequence of the underlying inflam ... | 2014 | 24918572 |
| safety of topical vancomycin for pediatric spinal deformity: nontoxic serum levels with supratherapeutic drain levels. | retrospective cohort analysis. | 2014 | 24921849 |
| in vitro evaluation of the anti-bacterial effect of two preparations of platelet rich plasma compared with cefazolin and whole blood. | this study investigates the antibacterial properties of two different platelet-rich plasma (prp) platelet concentration preparations (prplp and prphp) through a time-kill assay. | 2014 | 24932452 |
| enzymatic treatment of specimens before dna extraction directly influences molecular detection of infectious agents. | biological samples, pharmaceuticals or food contain proteins, lipids, polymers, ammoniums and macromolecules that alter the detection of infectious agents by dna amplification techniques (pcr). moreover the targeted dna has to be released from the complex cell walls and the compact nucleoprotein matrixes and cleared from potential inhibitors. the goal of the present work was to assess the efficiency of enzymatic pretreatments on infectious agents to make dna available for further extraction and ... | 2014 | 24936792 |
| subacute bacterial endocarditis and subsequent shunt nephritis from ventriculoatrial shunting 14 years after shunt implantation. | fourteen years after shunt implantation, a 26-year-old patient with myelomeningocele, concomitant hydrocephalus and a ventriculoatrial cerebrospinal fluid (csf) shunt presented with brief but recurrent episodes of fever predominantly when taking showers or during physical exertion. after 4 years of inconclusive multidisciplinary investigations, the patient progressed into end-stage renal disease before an echocardiogram revealed a vegetative plaque on the tendinous chords of the tricuspid valve. ... | 2014 | 24962489 |
| anti-propionibacterium acnes assay-guided purification of brazilin and preparation of brazilin rich extract from caesalpinia sappan heartwood. | caesalpinia sappan l. (leguminosae or fabaceae) heartwood has been used as a coloring agent, with antibacterial activity in food, beverages, cosmetics, and garments. | 2014 | 24963948 |
| complications of shoulder arthroscopy. | over the past 20 to 30 years, arthroscopic shoulder techniques have become increasingly popular. although these techniques have several advantages over open surgery, surgical complications are no less prevalent or devastating than those associated with open techniques. some of the complications associated with arthroscopic shoulder surgery include recurrent instability, soft-tissue injury, and neurapraxia. these complications can be minimized with thoughtful consideration of the surgical indicat ... | 2014 | 24966247 |
| management of deep postoperative shoulder infections: is there a role for open biopsy during staged treatment? | despite the gold standard treatment of 2-stage exchange arthroplasty, reinfection after periprosthetic shoulder infections and periarticular osteomyelitis can be as high as 37%. this study describes a protocol to detect persistent deep shoulder infection before revision arthroplasty. | 2015 | 24972813 |
| three dimensional distribution of propionibacterium acnes biofilms in human skin. | propionibacterium acnes is regarded as a common member of the human skin microbiota, often occurring in biofilms. little is known about the size of bacterial biofilms in hair follicles as a few sections of biopsy tissue are routinely evaluated. transversal sectioning provides a better opportunity for histological analyses of hair follicles which can be followed through the different morphological levels. direct visualization of p. acnes biofilms in hundreds of consecutive sections allowed insigh ... | 2014 | 24980271 |
| propionibacterium acnes: from commensal to opportunistic biofilm-associated implant pathogen. | propionibacterium acnes is known primarily as a skin commensal. however, it can present as an opportunistic pathogen via bacterial seeding to cause invasive infections such as implant-associated infections. these infections have gained more attention due to improved diagnostic procedures, such as sonication of explanted foreign materials and prolonged cultivation time of up to 14 days for periprosthetic biopsy specimens, and improved molecular methods, such as broad-range 16s rrna gene pcr. impl ... | 2014 | 24982315 |
| cellular activation in the immune response of sarcoidosis. | sarcoidosis is a chronic granulomatous disorder characterized by an accumulation of lymphocytes and macrophages in the alveoli. ultimately, long-lasting, nontreated disease results in a distortion of the microarchitecture of the lower respiratory tract. our current understanding of its pathogenesis is that several sequential immunological events finally resulting in granuloma formation are involved: (1) dependent on a susceptible genetic background described by a variety of functional polymorphi ... | 2014 | 25007083 |
| polymicrobial chronic endophthalmitis diagnosed by culture and molecular technique. | accurate etiological diagnosis is the key to prevention of ocular morbidity in endophthalmitis cases. a 66 year old male was suffering from chronic endophthalmitis post-cataract surgery. polymerase chain reaction examination on anterior chamber fluid was positive for propionibacterium acnes but negative for the panfungal genome. he was advised vitrectomy with intravitreal injections. polymerase chain reaction of vitreous aspirate was positive for p.acnes as well as panfungal genome. the vitreous ... | 2014 | 25008833 |
| propionibacterium acnes promotes th17 and th17/th1 responses in acne patients. | propionibacterium acnes is a gram-positive commensal bacterium thought to be involved in the pathogenesis of acne vulgaris. although the ability of p. acnes in the initiation of pro-inflammatory responses is well documented, little is known about adaptive immune responses to this bacterium. the observation that infiltrating immune cells consist mainly of cd4(+) t cells in the perifollicular space of early acne lesions suggests that helper t cells may be involved in immune responses caused by the ... | 2015 | 25010142 |
| self-reported acne is not associated with prostate cancer. | some studies have suggested an inverse association between acne vulgaris and the acne-related bacterium propionibacterium acnes and prostate cancer (pca). self-reported acne might be an easily obtainable marker to identify men at relatively low risk of pca and might be incorporated into pca risk calculators. this study aimed to evaluate the association between self-reported acne and pca in a large case-referent study. | 2014 | 25011577 |
| management of late (>1 y) deep infection after spinal fusion: a retrospective cohort study. | the incidence of late infection published in the literature varies from 1% to 12% with varying definition of late infection (range, 3 mo to 1 y). current evidence suggests implant removal and antibiotic therapy is necessary to clear these infections. a high incidence of late (>1 y) deep infection after instrumented spinal fusion was identified at our institution. we sought to evaluate the efficacy of our management of these patients. | 2015 | 25025743 |
| pacemaker endocarditis caused by propionibacterium acnes in an adult patient with ebstein's anomaly: a report of a rare case. | we report a rare case of a brazilian adult woman with ebstein's anomaly who presented with pacemaker endocarditis caused by propionibacterium acnes. ebstein's anomaly is a rare congenital malformation of the heart. infective endocarditis is defined as an infection of heart valves, of the mural endocardium, of a septal defect, or of a cardiac electronic implantable device. propionibacterium acnes is a skin commensal bacterium, that is usually considered as a contaminant, but can, on rare occasion ... | 2014 | 25047281 |
| protective effect of melittin against inflammation and apoptosis on propionibacterium acnes-induced human thp-1 monocytic cell. | melittin is a cationic, hemolytic peptide that is the main toxic component in the venom of the honey bee (apis mellifera). it has been used in treatment of various chronic inflammatory diseases. however, the cellular mechanism and the anti-apoptotic effect of melittin in propionibactierium acnes (p. acnes)-induced thp-1 cells have not been explored. in the present study, we investigated the anti-inflammatory and anti-apoptotic mechanism by examining the effect of melittin on p. acnes-induced thp ... | 2014 | 25062791 |
| fusidic acid in skin infections and infected atopic eczema. | skin infections represent an important public health issue and cost-driver. additionally, chronic skin lesions are sometimes colonized by gram-negative species. topical therapies are a key component in the management of mild-to-moderate skin infections. in such cases, topical antibiotics may be preferable to systemic treatment, since they maximize the effective doses at the site of infection while minimizing the systemic side effects of the drugs. however, the prevalence of resistant strains is ... | 2014 | 25068235 |
| inositol and acne. | acne, once considered as a mere esthetic problem, is now recognized as a disease that can cause major disturbances of the psychological and emotional sphere. currently, the treatment of acne is focused on one or more pathogenic factors: hormonal stimulation and sebaceous hypersecretion, disorder of keratinization, colonization of propionibacterium acnes and inflammation. the aim of the paper was to evaluate the use of inositol in patients with moderate acne. | 2015 | 25077885 |
| microbial community in persistent apical periodontitis: a 16s rrna gene clone library analysis. | to characterize the microbial composition of persistent periapical lesions of root filled teeth using a molecular genetics approach. | 2015 | 25088120 |
| a novel high-resolution single locus sequence typing scheme for mixed populations of propionibacterium acnes in vivo. | the gram-positive anaerobic bacterium propionibacterium acnes is a prevalent member of the normal skin microbiota of human adults. in addition to its suspected role in acne vulgaris it is involved in a variety of opportunistic infections. multi-locus sequence-typing (mlst) schemes identified distinct phylotypes associated with health and disease. being based on 8 to 9 house-keeping genes these mlst schemes have a high discriminatory power, but their application is time- and cost-intensive. here ... | 2014 | 25111794 |
| lipase-mediated lipid removal from propolis extract and its antiradical and antimicrobial activity. | propolis contains many antioxidants such as polyphenols and flavonoids. however, propolis-derived lipid components interrupt an efficient isolation of antioxidants from propolis extract. we examined the effectiveness of various lipase treatments for the removal of lipids from propolis extract and evaluated the biological features of the extract. | 2015 | 25123816 |
| draft genome sequences of propionibacterium acnes type strain atcc6919 and antibiotic-resistant strain hl411pa1. | propionibacterium acnes is a major skin commensal and is associated with acne vulgaris, the most common skin disease. here we report the draft genome sequences of two p. acnes strains, the type strain atcc6919 and an antibiotic-resistant strain, hl411pa1. | 2014 | 25125638 |
| the in vitro anti-acne activity of two unani drugs. | acne is the most common disorder treated by dermatologists. as many as 80-90% of all adolescents have some type of acne and 30% of them require medical treatment. it is an inflammatory disease of the pilosebaceous unit characterized by the formation of open and closed comedones, papules, pustules, nodules, and cysts. | 2013 | 25161328 |
| propionibacterium acnes populations involved in deep pathological samples and their dynamics along the cardiac surgical pathway. | propionibacterium acnes belongs to the normal skin microbiota, but it is also responsible for acne vulgaris and causes serious infections such as endocarditis and surgical site infections (ssi). the p. acnes population is structured into phylogenetic groups, with phylotype i being associated with acne. herein, we explore the link between phylotypes and clinical origins in a collection of p. acnes isolated from different body sites, involved in deep infections or healthcare-associated infections ... | 2015 | 25169966 |
| [advances in the research on bactericidal effect of blue light and its mechanism]. | blue light is commonly used to kill propionibacterium acnes in clinic. furthermore, blue light exhibits a good bactericidal effect against helicobacter pylori, methicillin-resistant staphylococcus aureus, pseudomonas aeruginosa, and many oral bacteria in laboratory studies. the bactericidal mechanism of blue light as commonly accepted consists photo-excitation of intracellular porphyrins resulting in production of cytotoxic reactive oxygen species which can inactivate bacteria. blue light can ki ... | 2014 | 25174390 |
| propionibacterium acnes in shoulder surgery: true infection, contamination, or commensal of the deep tissue? | propionibacterium acnes has been linked to chronic infections in shoulder surgery. whether the bacterium is a contaminant or commensal of the deep tissue is unclear. we aimed to assess p. acnes in intraoperative samples of different tissue layers in patients undergoing first-time shoulder surgery. | 2014 | 25179369 |
| propionibacterium persists in the skin despite standard surgical preparation. | propionibacterium acnes, which normally resides in the skin, is known to play a role in surgical site infection in orthopaedic surgery. studies have suggested a persistence of propionibacteria on the skin surface, with rates of positive cultures ranging from 7% to 29% after surgical preparation. however, as propionibacterium organisms normally reside in the dermal layer, these studies may underestimate the true prevalence of propionibacteria after surgical skin preparation. we hypothesized that, ... | 2014 | 25187583 |
| the immune response in sapho syndrome: deficiency, hyper- responsiveness, or both? | the pathophysiology of sapho syndrome still remains to be determined. however, like in other forms of spondylarthritides, this rare condition seems to result from the combination of genetic, environmental and immunological factors. surely, sapho syndrome cannot be simply regarded as the adult form of the 'caricatural' dira (deficiency in interleukin-1 receptor antagonist) syndrome, although this purely genetic disease also causes multiple osteomyelitis and pustular rashes. an initial bacterial t ... | 2013 | 25198361 |
| trends of sapho therapy: should we be content? | the interventional studies with bone biopsy of the sapho lesions and microbiological investigation are a significant addition to a long range of publications showing an association of sapho with propionibacterium acnes. infectious agents isolated from sapho patients have merited special attention for many years. their possible etiological role is supported by the pathogen isolation from different sites: anterior chest wall, spine, synovial fluid, bone tissue, and skin pustules. a range of pathog ... | 2013 | 25198365 |
| propionibacterium acnes infections in shoulder surgery. | perioperative shoulder infections involving propionibacterium acnes can be difficult to identify in a patient who presents with little more than pain and stiffness in the postoperative period. although indolent in its growth and presentation, infection of the shoulder with p acnes can have devastating effects, including failure of the surgical intervention. this article reviews the importance of a comprehensive physical, radiologic, and laboratory evaluation, and discusses appropriate preventive ... | 2014 | 25199422 |
| acute infection with propionibacterium acnes after a latarjet coracoid transfer procedure: a case report. | coracoid transfer procedures are highly effective at improving glenohumeral stability in patients with recurrent shoulder instability; complication rates from this procedure are generally low. we present the first case in the literature of a propionibacterium acnes (p. acnes) infection following a coracoid transfer. the case stresses the importance of proper antibiotic prophylaxis for patients undergoing latarjet procedures, as well as the workup for a painful postoperative shoulder, and the nee ... | 2016 | 25209204 |
| inhibitory effects of bee venom on propionibacterium acnes-induced inflammatory skin disease in an animal model. | propionibacterium acnes (p. acnes) is a major contributing factor to the inflammatory component of acne. the many prescription medications for acne allow for a large number of potential combination treatments. however, several antibiotics, apart from their antibacterial effects, exert side‑effects, such as the suppression of host inflammatory responses. purified bee venom (bv) is a natural toxin produced by honeybees (apis mellifera l.). bv has been widely used as a traditional medicine for vari ... | 2014 | 25215662 |
| resveratrol demonstrates antimicrobial effects against propionibacterium acnes in vitro. | resveratrol (3,5,4'-trihydroxystilbene) is an antioxidant that has multiple biologic effects including antimicrobial properties. acne vulgaris is a disease of the pilosebaceous unit, characterized by an inflammatory host immune response to the bacteria propionibacterium acnes (p. acnes). this study sought to determine whether resveratrol may be a potential treatment for acne vulgaris. | 2014 | 25228291 |
| proteome analysis of human sebaceous follicle infundibula extracted from healthy and acne-affected skin. | acne vulgaris is a very common disease of the pilosebaceous unit of the human skin. the pathological processes of acne are not fully understood. to gain further insight sebaceous follicular casts were extracted from 18 healthy and 20 acne-affected individuals by cyanoacrylate-gel biopsies and further processed for mass spectrometry analysis, aiming at a proteomic analysis of the sebaceous follicular casts. human as well as bacterial proteins were identified. human proteins enriched in acne and n ... | 2014 | 25238151 |
| aortic tube infections due to propionibacterium acnes. | 2014 | 25263822 | |
| role of bacterial biofilms in patients after reconstructive and aesthetic breast implant surgery. | capsular contracture is a feared complication following both reconstructive and aesthetic breast surgery. the etiology is uncertain, but bacterial biofilms have been suggested as trigger for chronic peri-implant inflammation, eventually leading to capsular contracture. | 2014 | 25272211 |
| propionibacterium species and follicular keratinocyte activation in acneic and normal skin. | the pathogenesis of acne vulgaris is multifactorial with increased sebum production, alteration in the quality of sebum lipids, dysregulation of the hormone microenvironment, follicular hyperkeratinization and propionibacterium acnes-driven inflammation as major contributory factors. hyperproliferation of keratinocytes is believed to contribute to hypercornification and eventually leads to comedone development. while the distribution of p. acnes is relatively well documented in acneic and health ... | 2015 | 25279837 |
| inhibitory and anti-inflammatory effects of the helicobacter pylori-derived antimicrobial peptide hpa3nt3 against propionibacterium acnes in the skin. | an effective treatment strategy for acne vulgaris is the reduction of propionibacterium acnes in the skin. the helicobacter pylori-derived synthetic antimicrobial peptide hpa3nt3 is a customized α-helical cationic peptide with antibacterial and anti-inflammatory activity. | 2014 | 25313444 |
| invasive propionibacterium acnes infections in a non-selective patient cohort: clinical manifestations, management and outcome. | an increasing number of reports suggest that propionibacterium acnes can cause serious invasive infections. currently, only limited data exist regarding the spectrum of invasive p. acnes infections. we conducted a non-selective cohort study at a tertiary hospital in the uk over a 9-year-period (2003-2012) investigating clinical manifestations, risk factors, management, and outcome of invasive p. acnes infections. forty-nine cases were identified; the majority were neurosurgical infections and or ... | 2015 | 25326276 |
| an in vitro experimental study on the antimicrobial activity of silicone oil against anaerobic bacteria. | to investigate the in vitro antimicrobial activity of silicone oil against anaerobic agents, specifically propionibacterium acnes, peptostreptococcus spp., peptostreptococcus anaerobius, bacteroides fragilis, fuobacterium spp., and clostridium tertium. | 2016 | 25356916 |
| infection of cardiovascular implantable electronic devices: detection with sonication, swab cultures, and blood cultures. | the number of patients with cardiovascular implantable electronic devices (cieds) is increasing. the purpose of this study was to compare three methods (sonication, swab cultures, and blood cultures) to detect bacteria in infections of cieds. | 2015 | 25377386 |
| fatty acid compositions of triglycerides and free fatty acids in sebum depend on amount of triglycerides, and do not differ in presence or absence of acne vulgaris. | to clarify the influence of the fatty acid composition of sebum in acne vulgaris, we investigated the amounts and fatty acid compositions of triglycerides (tg) and free fatty acids (ffa), and the amounts of cutaneous superficial propionibacterium acnes in acne patients and healthy subjects. the foreheads of 18 female patients, 10 male patients, 10 healthy females and 10 healthy males were studied in a japanese population. there were significant differences in the amounts of sebum, tg and cutaneo ... | 2014 | 25388081 |
| recent advances in acne pathogenesis: implications for therapy. | acne pathogenesis is a multifactorial process that occurs at the level of the pilosebaceous unit. while acne was previously perceived as an infectious disease, recent data have clarified it as an inflammatory process in which propionibacterium acnes and innate immunity play critical roles in propagating abnormal hyperkeratinization and inflammation. alterations in sebum composition, and increased sensitivity to androgens, also play roles in the inflammatory process. a stepwise approach to acne m ... | 2014 | 25388823 |
| comparison of airborne bacterial communities from a hog farm and spray field. | airborne bacteria from hog farms may have detrimental impacts on human health, particularly in terms of antibiotic resistance and pathogen zoonosis. despite human health risks, very little is known about the composition and diversity of airborne bacteria from hog farms and hog-related spray fields. we used pyrosequencing analysis of 16s rrna genes to compare airborne bacterial communities in a north carolina hog farm and lagoon spray field. in addition, we isolated and identified antibiotic-resi ... | 2015 | 25406533 |
| unexpected positive cultures including isolation of propionibacterium acnes in revision shoulder arthroplasty. | little information is available to guide treatment strategies regarding patients with unexpected positive cultures (upc), including propionibacterium acnes (pa), without overt signs of infection in revision shoulder arthroplasty (rsa). the purpose of our study was to analyze the prevalence, clinical meaning, treatment and prognosis of upc in rsa. | 2014 | 25421200 |
| cosmeceuticals based on rhealba(®) oat plantlet extract for the treatment of acne vulgaris. | recent evidence suggests that acne vulgaris begins as an inflammation in and around the sebaceous gland and alterations in the lipid content of sebum, which drive hyperproliferation and increased desquamation of keratinocytes within sebaceous follicles. this prevents sebum drainage, causing the formation of microcomedones, which spontaneously regress or become acne lesions when the pilosebaceous unit is further blocked by the accumulation of corneocytes. these conditions are favourable for the p ... | 2014 | 25428278 |
| development of antimicrobial resistance in the normal anaerobic microbiota during one year after administration of clindamycin or ciprofloxacin. | thirty healthy subjects (15 males and 15 females) were randomly assigned in three groups and clindamycin (150 mg qid) or ciprofloxacin (500 mg bid) or placebo was given for a 10-day period. skin, nasal, saliva, faeces samples were collected at day - 1, day 11, 1 month, 2 months, 4 months and 12 months post administration for microbiological analysis. ciprofloxacin or clindamycin had no impact on the anaerobic skin microbiota and the proportions of antibiotic resistant anaerobic bacteria were sim ... | 2015 | 25445201 |
| mlst typing of antimicrobial-resistant propionibacterium acnes isolates from patients with moderate to severe acne vulgaris. | molecular typing data on antimicrobial-resistant propionibacterium strains are limited in the literature. we examined antimicrobial resistance profiles and the underlying resistance mechanisms in propionibacterium spp. isolates recovered from patients with moderate to severe acne vulgaris in greece. the clonallity of the resistant propionibacterium acnes isolates was also investigated. propionibacterium spp. isolates were detected using tryptone-yeast extract-glucose (tyg) agar plates supplement ... | 2015 | 25451716 |
| treatment of acne with tea tree oil (melaleuca) products: a review of efficacy, tolerability and potential modes of action. | over-the-counter acne treatments containing tea tree oil from the plant melaleuca alternifolia are widely available, and evidence indicates that they are a common choice amongst those self-treating their acne. the aims of this review were to collate and evaluate the clinical evidence on the use of tea tree oil products for treating acne, to review safety and tolerability and to discuss the underlying modes of therapeutic action. | 2015 | 25465857 |
| arthroscopic tissue culture for the evaluation of periprosthetic shoulder infection. | periprosthetic shoulder infections can be difficult to diagnose. the purpose of this study was to investigate the utility of arthroscopic tissue culture for the diagnosis of infection following shoulder arthroplasty. our hypothesis was that culture of arthroscopic biopsy tissue is a more reliable method than fluoroscopically guided shoulder aspiration for diagnosing such infection. | 2014 | 25471909 |
| emerging drugs for the treatment of acne. | acne is the most common skin condition in the us. the mainstay of acne therapy includes: topical retinoids, topical antibiotics, benzoyl peroxide (bp), and oral isotretinoin for severe cases. although these treatment options are highly effective they do have certain drawbacks. current acne treatment regimens often require patients to use multiple medications, some of which may have irritating side effects. furthermore, propionibacterium acnes resistance to antibiotics has become an increasing pr ... | 2015 | 25474485 |
| update on blood culture-negative endocarditis. | blood culture-negative endocarditis is often severe, and difficult to diagnose. the rate of non-documented infective endocarditis has decreased with the advent of molecular biology - improved performance for the diagnosis of bacterial endocarditis with blood cultures sterilized by previous antibacterial treatment - and cardiac surgery - access to the main infected focus, the endocardium, for half of the patients. blood culture-negative endocarditis are classified in 3 main categories: (i) bacter ... | 2015 | 25480453 |
| synergistic effect of 2% chlorhexidine combined with proteolytic enzymes on biofilm disruption and killing. | to investigate the dynamics of a disinfection regimen using 1% trypsin and 1% proteinase k in combination with 2% chlorhexidine (with or without ultrasonics) using a nutrient-stressed endodontic multispecies model biofilm. | 2015 | 25482847 |
| presence of propionibacterium acnes in primary shoulder arthroscopy: results of aspiration and tissue cultures. | infection after shoulder surgery has a serious impact on patient outcome and costs associated with care. propionibacterium acnes infection may be insidious and manifest years after index surgery with resultant joint arthropathy or prosthesis infection. our goal was to evaluate the presence of p. acnes in a group of patients undergoing primary arthroscopic shoulder surgery to better understand this organism. | 2015 | 25483906 |
| the effect of axillary hair on surgical antisepsis around the shoulder. | infection after shoulder surgery can have devastating consequences. recent literature has implicated propionibacterium acnes as a causative agent for postoperative shoulder infections. axillary hair removal has been suggested as a method for infection prevention, although data quantifying its effect on the bacterial load around the shoulder are lacking. | 2015 | 25487899 |
| preoperative and intraoperative infection workup in apparently aseptic revision shoulder arthroplasty. | the possibility of infection should be considered in every revision shoulder arthroplasty even in the absence of clinical symptoms and signs of infection because indolent infection is prevalent. detection of infection in apparently aseptic failed arthroplasties poses a diagnostic challenge as the conventional principles and criteria used for hip and knee arthroplasty are not generally applicable. propionibacterium acnes and staphylococcus epidermidis are among the infectious organisms most commo ... | 2015 | 25487903 |
| curcumin attenuated acute propionibacterium acnes-induced liver injury through inhibition of hmgb1 expression in mice. | curcumin is a phenolic product isolated from the rhizome of curcuma longa and has protective effects on inflammatory diseases. here we investigated the protective effect of curcumin in acute propionibacterium acnes (p. acnes)-induced inflammatory liver injury. c57bl/6 mice were primed with p. acnes followed by lps challenge to induce fulminant hepatitis. curcumin or vehicle control was administered perorally by gavage once daily starting 2days before p. acnes priming. we found that curcumin sign ... | 2015 | 25510585 |
| matrix-assisted laser desorption ionization time of flight mass spectrometry and diagnostic testing for prosthetic joint infection in the clinical microbiology laboratory. | identification of pathogen(s) associated with prosthetic joint infection (pji) is critical for patient management. historically, many laboratories have not routinely identified organisms such as coagulase-negative staphylococci to the species level. the advent of matrix-assisted laser desorption ionization time of flight mass spectrometry (maldi-tof ms) has enhanced clinical laboratory capacity for accurate species-level identification. the aim of this study was to describe the species-level ide ... | 2015 | 25533615 |
| antibiotic susceptibility of propionibacterium acnes isolated from orthopaedic implant-associated infections. | prosthetic joint infections (pjis) caused by propionibacterium acnes account for a larger proportion of the total number of pjis than previously assumed and thus knowledge of the antimicrobial susceptibility patterns of p. acnes is of great value in everyday clinical practice. | 2015 | 25541476 |
| synovial fluid interleukin-6 as a predictor of periprosthetic shoulder infection. | diagnosis of periprosthetic joint infection (pji) in patients undergoing revision shoulder arthroplasty is challenging because of the low virulence of the most common infecting organisms. the goal of this study was to evaluate the diagnostic utility of measuring synovial fluid interleukin-6 (il-6) levels for identifying pji of the shoulder. | 2015 | 25568396 |
| variants in sell, mrps36p2, tp63, ddb2, cacna1h, adam19, gnai1, cdh13 and gabrg2 interact to confer risk of acne in chinese population. | acne vulgaris is a common skin disease characterized by chronic inflammation of the pilosebaceous unit resulting from androgen-induced increased sebum production, altered keratinization, inflammation and bacterial colonization of hair follicles by propionibacterium acnes. our previous genome-wide association study on acne has identified two new susceptibility loci. to search for potential gene-gene interactions and investigate the best-fit association models for the single nucleotide polymorphis ... | 2015 | 25573302 |
| antimicrobial activity and mechanism of action of a novel cationic α-helical octadecapeptide derived from α-amylase of rice. | amyi-1-18, an octadecapeptide derived from α-amylase (amyi-1) of rice (oryza sativa l. japonica), is a novel cationic α-helical antimicrobial peptide (amp) that contains two lysine and two arginine residues. the antimicrobial activity of amyi-1-18 against human pathogens was quantitatively evaluated using a chemiluminescence method that measures atp derived from viable cells. of the ten kinds of human pathogens, amyi-1-18 exhibited antimicrobial activity against nine. its 50% growth-inhibitory c ... | 2015 | 25581614 |
| management of propionibacterium acnes infection after shoulder surgery. | propionibacterium acnes (p. acnes) is a gram-positive anaerobic bacillus commonly isolated from the flora of the face, chest, and axilla region. it has emerged as a major pathogen responsible for postoperative shoulder infections after both arthroscopy and arthroplasty procedures. patients with p. acnes shoulder infection typically present with normal laboratory values (white blood cells (wbc), erythrocyte sedimentation rate (esr), and c-reactive protein (crp)) making diagnosis difficult. severa ... | 2015 | 25596729 |
| typing of propionibacterium acnes: a review of methods and comparative analysis. | propionibacterium acnes is a major commensal of the human skin. however, it is also the pathogen responsible for acne vulgaris and other diseases, such as medical-device infections. strains of propionibacterium acnes have long been classified into several different types. recently, typing systems for this bacterium have taken on an increased importance as different types of p. acnes have been found to be associated with different disease states, including acne. genetic approaches based on indivi ... | 2015 | 25600912 |
| antimicrobial efficacy of granulysin-derived synthetic peptides in acne vulgaris. | antimicrobial peptides are considered as a potential alternative to antibiotic treatment in acne vulgaris because the development of a resistant strain of propionibacterium acnes is problematic. granulysin can be regarded as an ideal substance with which to treat acne because it has antimicrobial and anti-inflammatory effects. | 2015 | 25601314 |
| could low grade bacterial infection contribute to low back pain? a systematic review. | recently, there has been both immense interest and controversy regarding a randomised, controlled trial which showed antibiotics to be effective in the treatment of chronic low back pain (disc herniation with modic type 1 change). while this research has the potential to result in a paradigm shift in the treatment of low back pain, several questions remain unanswered. this systematic review aims to address these questions by examining the role of bacteria in low back pain and the relationship be ... | 2015 | 25609421 |
| the detection of propionibacterium acnes signatures in granulomas of lupus miliaris disseminatus faciei. | lupus miliaris disseminatus faciei (lmdf) is a papular eruption that occurs on adults' faces, predominantly on the lower eyelids. histologically, the granulomatous lesions are primarily situated around the hair follicles, particularly the superficial region/infundibula. its etiology remains to be elucidated. recently, propionibacterium acnes (p. acnes) has been suspected as a cause of sarcoidosis. in light of the sarcoid-like reactions that are present in lmdf, we hypothesized that p. acnes may ... | 2015 | 25616106 |
| antimicrobial photodynamic therapy using chlorin e6 with halogen light for acne bacteria-induced inflammation. | the present study was designed to evaluate the therapeutic potential of antimicrobial photodynamic therapy (pdt) using chlorin e6 with halogen light against acne bacteria-induced inflammation. | 2015 | 25623849 |
| multiplex touchdown pcr for rapid typing of the opportunistic pathogen propionibacterium acnes. | the opportunistic human pathogen propionibacterium acnes is composed of a number of distinct phylogroups, designated types ia1, ia2, ib, ic, ii, and iii, which vary in their production of putative virulence factors, their inflammatory potential, and their biochemical, aggregative, and morphological characteristics. although multilocus sequence typing (mlst) currently represents the gold standard for unambiguous phylogroup classification and individual strain identification, it is a labor-intensi ... | 2015 | 25631794 |
| macrophages largely contribute to heterologous anti-propionibacterium acnes antibody-mediated protection from actinobacillus pleuropneumoniae infection in mice. | actinobacillus pleuropneumoniae is the causative agent of acute and chronic pleuropneumonia. propionibacterium acnes is a facultative anaerobic gram-positive corynebacterium. we have previously found that anti-p. acnes antibodies can prevent a. pleuropneumoniae infections in mice. to investigate the role of macrophages in this process, affinity-purified anti-p. acnes igg and anti-a. pleuropneumoniae igg were used in opsonophagocytosis assays. additionally, the efficacy of passive immunization wi ... | 2015 | 25644652 |
| what's new in the physiopathology of acne? | there are four central factors that contribute to acne physiopathology: the inflammatory response, colonization with propionibacterium acnes, increased sebum production and hypercornification of the pilosebaceous duct. in addition, research in the areas of diet and nutrition, genetics and oxidative stress is also yielding some interesting insights into the development of acne. in this paper we review some of the most recent research and novel concepts revealed in this work, which has been publis ... | 2015 | 25645151 |
| pentobra: a potent antibiotic with multiple layers of selective antimicrobial mechanisms against propionibacterium acnes. | although antibiotics are a common treatment for acne, the difficulties inherent to effective antimicrobial penetration in sebum and selective antimicrobial action in the skin are compounded by increasing resistance of propionibacterium acnes clinical isolates. to address these problems, we engineered pentobra, a peptide-aminoglycoside molecule that has multiple mechanisms of antibacterial action and investigated whether it can be a potential candidate for the treatment of acne. pentobra combines ... | 2015 | 25668237 |
| α-defensin as a predictor of periprosthetic shoulder infection. | diagnosis of periprosthetic joint infection (pji) in revision shoulder arthroplasty can be challenging because of the indolent nature of the common offending organisms. the purpose of this study was to evaluate the diagnostic utility of synovial fluid α-defensin levels in identifying pji of the shoulder. | 2015 | 25672257 |
| reduced expression of dermcidin, a peptide active against propionibacterium acnes, in sweat of patients with acne vulgaris. | dermcidin (dcd), an antimicrobial peptide with a broad spectrum of activity against bacteria such as propionibacterum acnes, is expressed constitutively in sweat in the absence of stimulation due to injury or inflammation. the aim of this study was to determine the relationship between dcd expression and acne vulgaris associated with p. acnes. the antimicrobial activity of recombinant full-length dcd (50 μg/ml) was 97% against escherichia coli and 100% against staphylococcus aureus. antimicrobia ... | 2015 | 25673161 |
| topical acne treatments in europe and the issue of antimicrobial resistance. | acne vulgaris (acne) is a chronic inflammatory disease of the sebaceous gland, characterized by follicular hyperkeratinization, excessive colonization by propionibacterium acnes (p. acnes) as well as immune reactions and inflammation. despite an armamentarium of topical treatments available including benzoyl peroxide, retinoids and azelaic acid, topical antibiotics in monotherapies, especially erythromycin and clindamycin, are still used in europe to treat acne. this intensive use led to antimic ... | 2015 | 25677763 |
| immunoproteomic identification of in vivo-produced propionibacterium acnes proteins in a rabbit biofilm infection model. | propionibacterium acnes is well-known as a human skin commensal but can also act as an invasive pathogen causing implant-associated infections. in order to resolve these types of p. acnes infections, the implants must be removed, due to the presence of an established biofilm that is recalcitrant to antibiotic therapy. in order to identify those p. acnes proteins produced in vivo during a biofilm infection, we established a rabbit model of implant-associated infection with this pathogen. p. acnes ... | 2015 | 25694647 |
| low rate of propionibacterium acnes in arthritic shoulders undergoing primary total shoulder replacement surgery using a strict specimen collection technique. | propionibacterium acnes is a recognized pathogen in postoperative shoulder infections. a recent study reported growth of p acnes in 42% of glenohumeral joints in primary shoulder arthroplasty, concluding that p acnes may cause shoulder osteoarthritis. whether these results reflect true bacterial infection or specimen contamination is unclear. our prospective study aimed to determine the rate of p acnes infection in arthritic shoulders using a strict specimen collection technique. | 2015 | 25700640 |
| infection after primary anatomic versus primary reverse total shoulder arthroplasty. | deep periprosthetic infection is a serious complication after total shoulder arthroplasty (tsa) and is associated with suboptimal clinical results. this retrospective study aimed to determine whether a difference in infection rate existed after primary anatomic tsa (atsa) and primary reverse tsa (rtsa). | 2015 | 25704211 |
| inhibition of lipase and inflammatory mediators by chlorella lipid extracts for antiacne treatment. | acne vulgaris is a chronic inflammatory disease, and its treatment is challenging due to the multifactorial etiology and emergence of antibiotic-resistant propionibacterium acnes strains. this study was focused to reduce antibiotics usage and find an alternate therapeutic source for treating acne. lipid extracts of six chlorella species were tested for inhibition of lipase, reactive oxygen species (ros) production, cytokine production using p. acnes (microbial type culture collection 1951). lipa ... | 2017 | 25709963 |
| p38 map kinase inhibition reduces propionibacterium acnes-induced inflammation in vitro. | propionibacterium acnes, a ubiquitous skin bacterium, stimulates keratinocytes to produce a number of proinflammatory cytokines and may contribute to inflammatory acne. the aim of the study was to investigate whether p. acnes-induced proinflammatory cytokine release is mediated by p. acnes-induced activation of p38 mitogen-activated protein kinase (p38 mapk or p38) in human keratinocytes. | 2015 | 25749612 |
| is hemolysis a clinical marker of propionibacterium acnes orthopedic infection or a phylogenetic marker? | 2015 | 25750950 | |
| viable bacteria associated with red blood cells and plasma in freshly drawn blood donations. | infection remains a leading cause of post-transfusion mortality and morbidity. bacterial contamination is, however, detected in less than 0.1% of blood units tested. the aim of the study was to identify viable bacteria in standard blood-pack units, with particular focus on bacteria from the oral cavity, and to determine the distribution of bacteria revealed in plasma and in the red blood cell (rbc)-fraction. | 2015 | 25751254 |