Publications
| Title | Abstract | Year Filter | PMID(sorted ascending) Filter |
|---|
| antihypertensive therapy: newer concepts and agents. | major advances have taken place in recent years with respect to our understanding of hypertensive diseases, the mechanisms of action of other therapeutic agents, and the introduction of new classes of drugs. standard therapy today uses the basic of employing nonpharmacological modalities. thereafter a stepped-care program with pharmacological entities has been advocated using diuretic, antiadrenergic, and vasodilating agents. however, new modes of action have been introduced therapeutically duri ... | 2009 | 2866842 |
| psychosocial and physiological factors in relation to blood pressure at rest--a study of swedish men in their upper twenties. | the interrelationships between psychosocial factors, several physiological variables and blood pressure (bp) were investigated in 88 young men (aged 26-32 years) in whom high, intermediate or low bp had been recorded at the age of 18 years. in the original high bp group, venous plasma noradrenaline was normal but adrenaline levels elevated. at the follow-up adrenaline correlated with systolic blood pressure (sbp), and this was also so after controlling for overweight and serum gamma-glutamyltran ... | 2010 | 2868055 |
| blood coagulability and viper envenomation. | 2010 | 2869321 | |
| she should not have chewed. | 2010 | 2869327 | |
| effect of activated lymphocytes on the regulation of hematopoiesis: enhancement and suppression of in vitro bfu-e growth by t cells stimulated by autologous non-t cells. | autologous mixed lymphocyte culture (amlr) is an immunologic response with memory and specificity and plays a role in immune regulation. effects of t cells activated by amlr were studied in the regulation of in vitro erythropoiesis. amlr-activated t cells were cocultured with autologous non-t, nonphagocytic peripheral blood mononuclear cells for assaying erythroid progenitor cells (bfu-e). t cells activated for 3 days in amlr showed significant enhancement of in vitro colony growth by bfu-e. in ... | 2002 | 2869804 |
| the time course of effects of cadmium and 3-methylcholanthrene on activities of enzymes of xenobiotic metabolism and metallothionein levels in the plaice, pleuronectes platessa. | plaice were treated with an acute dose of a polyaromatic hydrocarbon (3-methylcholanthrene, 3-mc) or cadmium, or 3-mc and cadmium by i.p. injection. the effects on hepatic detoxication systems, cytochrome p-450 (ethoxyresorufin o-deethylase, erod), udp-glucuronyl transferase, glutathione s-transferase, glutathione peroxidase activities, total glutathione (gsh), metallothionein and cd and zn in the cytosol were studied over a 14 day period. 3-mc increased erod (7-18-fold), glucuronyl transferase ... | 2002 | 2869905 |
| direct evidence for a stimulatory effect of hyperglycemia per se on peripheral glucose disposal in type ii diabetes. | the effect of hyperglycemia per se on glucose uptake by muscle tissue was quantitated in six controls and six type ii diabetics by the forearm technique, under conditions of insulin deficiency induced by somatostatin (srif) infusion (0.7 mg/h). blood glucose concentration was clamped at its basal value during the first 60 min of srif infusion and then raised to approximately 200 mg/dl by a variable glucose infusion. plasma insulin levels remained at or below 5 microu/ml during srif infusion, inc ... | 2004 | 2870077 |
| necrotising enterocolitis. | 2004 | 2870107 | |
| glial differentiation in dissociated cell cultures of neonatal rat brain: noncoordinate and density-dependent regulation of oligodendroglial enzymes. | the mixed glial system of primary cultures of cells dissociated from neonatal rat brain was utilized to study glial differentiation. the investigation was addressed specifically to the possibility of noncoordinate regulation of two manifestations of oligodendroglial differentiation, i.e., activities of glycerol-3-phosphate dehydrogenase (gpdh) and of 2',3'-cyclic nucleotide 3'-phosphohydrolase (cnp), as well as the effects of initial cell density on the time of onset and the intensity of express ... | 1986 | 2870195 |
| transglutaminase and neuronal differentiation. | during mouse brain maturation cellular transglutaminase specific activity increases 2.5 fold from day 3 to adulthood. a more pronounced increase is seen during morphological differentiation of mouse neuroblastoma cells, where serum withdrawal induces neurite outgrowth concomitant with a 10 fold increase in transglutaminase specific activity. in contrast, non-dividing neuroblastoma cells lacking neurites show only a 1.5 fold increase in enzyme specific activity. transglutaminase activity does not ... | 1986 | 2870428 |
| transglutaminase and neuronal differentiation. | during mouse brain maturation cellular transglutaminase specific activity increases 2.5 fold from day 3 to adulthood. a more pronounced increase is seen during morphological differentiation of mouse neuroblastoma cells, where serum withdrawal induces neurite outgrowth concomitant with a 10 fold increase in transglutaminase specific activity. in contrast, non-dividing neuroblastoma cells lacking neurites show only a 1.5 fold increase in enzyme specific activity. transglutaminase activity does not ... | 1986 | 2870428 |
| integrating treatments in schizophrenia. | schizophrenia is a common and severe illness found throughout the world. onset is usually in adolescence and young adulthood, and many individuals have illness-related impairments for life. schizophrenia assaults the very essence of what is distinctly human. the personality is devastated, subjective experience and thought distorted, and the psychological building blocks of everyday life torn asunder. this article discusses diagnostic and conceptual considerations, pharmacotherapy, and interperso ... | 1986 | 2870478 |
| influence of dietary lipids on the effect of chlorpromazine on membrane properties of rabbit red cells. | the effect of diets containing different types of common natural oils on physical properties of red cells was investigated by using rabbits. the rabbits were fed for 18 months on a standard diet in which 8% of its energy content was provided by safflower oil and 32% energy by either more safflower oil or fish oil, linseed oil, olive oil or palm oil. erythrocyte deformability was significantly decreased by the fish oil diet compared with each of the other diets. osmotic fragility was significantl ... | 1986 | 2870499 |
| platelet aggregation caused by carybdea rastonii toxins (crtx-i, ii and iii) obtained from a jellyfish, carybdea rastonii. | the pharmacological mechanisms of platelet aggregation induced by highly toxic proteins (crtx-i, crtx-ii, and crtx-iii) obtained from tentacles of a jellyfish, carybdea rastonii, were investigated. when the partially purified toxin (pcrtx) and crtxs were added to the citrated platelet-rich plasma (prp), aggregation was produced in a concentration-dependent manner. the activity of crtxs was approximately 100 times more potent than pcrtx. the crtxs-induced aggregation was little affected by indome ... | 1986 | 2870502 |
| mitochondrial dna and the evolutionary genetics of higher animals. | mitochondrial dna (mtdna) in higher animals is rapidly becoming a well characterized genetic system at the molecular level. in this paper, i shift the focus to consider questions in organismal evolution that can be addressed by mtdna assay. for the first time, it is possible to estimate empirically matriarchal phylogeny; to determine directionality in crosses producing hybrids; and to study the population genetic consequences of varying female demographies and life histories. the data obtainable ... | 2006 | 2870525 |
| [indicative patterns of the use of anxiolytic agents in pharmacies and the severity of symptoms]. | 2006 | 2870538 | |
| [indicative patterns of the use of anxiolytic agents in pharmacies and the severity of symptoms]. | 2006 | 2870538 | |
| effects on angina pectoris and exercise tests of a 2% nitroglycerin gel adhesive in patients on chronic beta-blockade. a placebo-controlled study. | twenty patients on chronic beta-blockade for angina pectoris were included in a double-blind randomized cross-over placebo-controlled study on a 2% nitroglycerin gel administered transdermally by an adhesive. topinitro. the dose, 2.5-10 mg/day, was individually titrated and each treatment period was 28 days. the effect was evaluated by exercise tests and diary cards for anginal attacks and nitroglycerin tablets consumed. results. in the 17 patients who completed the trial, active treatment did n ... | 2006 | 2870610 |
| effects on angina pectoris and exercise tests of a 2% nitroglycerin gel adhesive in patients on chronic beta-blockade. a placebo-controlled study. | twenty patients on chronic beta-blockade for angina pectoris were included in a double-blind randomized cross-over placebo-controlled study on a 2% nitroglycerin gel administered transdermally by an adhesive. topinitro. the dose, 2.5-10 mg/day, was individually titrated and each treatment period was 28 days. the effect was evaluated by exercise tests and diary cards for anginal attacks and nitroglycerin tablets consumed. results. in the 17 patients who completed the trial, active treatment did n ... | 2006 | 2870610 |
| [nailbed transplantation, a possibility for reconstruction]. | to satisfy the demands of tactile gnosis, it is necessary to have intact fingertips. for this purpose, the fingernail has an important function. with the help of an example of a nailbed transplantation after a complete amputation of a finger end, a possibility of reconstruction of injured fingertips, especially of the nailbed, is shown. attention is called to the importance of an exact primary treatment of injured nailbeds. | 2006 | 2870619 |
| [nailbed transplantation, a possibility for reconstruction]. | to satisfy the demands of tactile gnosis, it is necessary to have intact fingertips. for this purpose, the fingernail has an important function. with the help of an example of a nailbed transplantation after a complete amputation of a finger end, a possibility of reconstruction of injured fingertips, especially of the nailbed, is shown. attention is called to the importance of an exact primary treatment of injured nailbeds. | 2006 | 2870619 |
| glucose counterregulation in diabetic autonomic neuropathy. | 2007 | 2870835 | |
| glucose counterregulation in diabetic autonomic neuropathy. | 2007 | 2870835 | |
| blood-finding strategy of a capillary-feeding sandfly, lutzomyia longipalpis. | salivary gland homogenates of adult female lutzomyia longipalpis inhibited platelet aggregation induced by adp and collagen. apyrase (atp diphosphohydrolase) activity was prominent, requiring ca2+ but not mg2+ and a ph optimum of 8.0. human as well as rabbit hosts developed a well delimited erythema, evident 2-3 min after initial probing and lasting for as long as 2 days. erythema, not accompanied by itching or swelling, developed in previously exposed hosts as well as in those not previously ex ... | 1986 | 2870860 |
| blood-finding strategy of a capillary-feeding sandfly, lutzomyia longipalpis. | salivary gland homogenates of adult female lutzomyia longipalpis inhibited platelet aggregation induced by adp and collagen. apyrase (atp diphosphohydrolase) activity was prominent, requiring ca2+ but not mg2+ and a ph optimum of 8.0. human as well as rabbit hosts developed a well delimited erythema, evident 2-3 min after initial probing and lasting for as long as 2 days. erythema, not accompanied by itching or swelling, developed in previously exposed hosts as well as in those not previously ex ... | 1986 | 2870860 |
| pharmacokinetics of t-2 toxin and its metabolite ht-2 toxin, after intravenous administration in dogs. | the pharmacokinetics of t-2 toxin and ht-2 toxin were investigated comparatively in five dogs, after iv administration of the toxins (0.4 mg/kg). t-2 toxin was very rapidly and almost completely biotransformed to ht-2 toxin (fm = 83.6 +/- 3.9%). the following mean pharmacokinetic parameters were determined in this study for t-2 toxin and ht-2 toxin, respectively: half-life 5.3 +/- 2.1 and 19.6 +/- 4.7 min, clearance 0.107 +/- 0.056 and 0.167 +/- 0.074 liters/min/kg, and volume of distribution 0. ... | 1986 | 2870902 |
| pharmacokinetics of t-2 toxin and its metabolite ht-2 toxin, after intravenous administration in dogs. | the pharmacokinetics of t-2 toxin and ht-2 toxin were investigated comparatively in five dogs, after iv administration of the toxins (0.4 mg/kg). t-2 toxin was very rapidly and almost completely biotransformed to ht-2 toxin (fm = 83.6 +/- 3.9%). the following mean pharmacokinetic parameters were determined in this study for t-2 toxin and ht-2 toxin, respectively: half-life 5.3 +/- 2.1 and 19.6 +/- 4.7 min, clearance 0.107 +/- 0.056 and 0.167 +/- 0.074 liters/min/kg, and volume of distribution 0. ... | 1986 | 2870902 |
| two bradykinin binding sites with picomolar affinities. | bradykinin (bk) and related peptides exert a wide range of effects on several organ systems. we have attempted to sort out these effects by studying the binding interaction of [3h]bk at the membrane level with in vitro receptor binding techniques. high specific activity [3h]bk and an enzyme inhibitor "cocktail" has enabled us to label two bk binding sites with different affinity and peptide specificity in several guinea-pig tissues. in the guinea-pig ileum the high-affinity site has an equilibri ... | 1986 | 2871174 |
| the effects of a supratentorial mass lesion on brain-stem auditory evoked potentials and short latency somatosensory evoked potentials. | nineteen patients with unilateral supratentorial mass lesion and without any evident clinical signs of transtentorial herniation were studied with computed tomography (ct), brain-stem evoked potentials (baeps) and central conduction time (cct) of short latency somatosensory evoked potentials (seps). sixteen had tumours, two had intracranial haematoma and one had chronic subdural haematoma. ct detected the initial signs of transtentorial herniation in every case. preoperative i-v interpeak latenc ... | 2010 | 2871503 |
| insulin and glucagon response of the diabetic chinese hamster in the asahikawa colony. | the relationship between pancreatic hormone content and pattern of hormone release has not been completely elucidated because of heterogeneity in diabetes. accordingly, this study was performed to establish the relationship, using spontaneously diabetic chinese hamsters in the asahikawa colony, a newly discovered experimental model resembling insulin-deficient diabetes in humans. as a result of investigations of insulin and glucagon responses to glucose or arginine in vivo and in vitro using iso ... | 2009 | 2873008 |
| design of eyedropper tips for topical beta-blocking agents. | 2003 | 2873745 | |
| potent antagonism of escherichia coli, bacteroides ovatus, fusobacterium varium, and enterococcus faecalis, alone or in combination, for enteropathogens in anaerobic continuous flow cultures. | interactions between representative strains of four predominant resident bacteria of the human colon, escherichia coli, enterococcus faecalis, bacteroides ovatus, and fusobacterium varium, and strains of seven enteropathogens, yersinia enterocolitica, shigella flexneri, salmonella typhimurium, vibrio parahaemolyticus, v. cholerae serogroup non o1, staphylococcus aureus, and clostridium perfringens, were examined in studies with an anaerobic continuous flow culture system and medium resembling th ... | 1986 | 2875188 |
| the neurobiologic consequences of down syndrome. | trisomy of the whole or distal part of human chromosome 21 (hsa 21) (ts21) results in down syndrome (ds), which is characterized in part by mental retardation and associated neurological abnormalities. structural abnormalities observed frequently include reduced brain weight, decreased number and depth of sulci in the cerebral cortices, neuronal heterotopias, and reduced numbers of specific populations of neurons, such as granule cells, in the cerebral cortices. abnormalities in the structure of ... | 1986 | 2875770 |
| somatostatin analogue sms 201-995 in type i diabetes mellitus. initial experience after repeated administration. | we have recently obtained encouraging short-term results after a single subcutaneous injection of the long-acting somatostatin analogue sms 201-995 in acromegalic patients. increased growth hormone (gh) levels may be involved in the pathogenesis of proliferative retinopathy in type i diabetes mellitus. in this study we thus investigated the effect of 3 x 50 micrograms sms 201-995 daily on the metabolic control and hormone secretion of eight type i diabetics over a 3-day period. gh levels decreas ... | 2010 | 2876502 |
| [hemorrhagic fever with renal syndrome. a survey of zoonosis]. | 2010 | 2876539 | |
| the fine structure of atypical ciliated cells in the human gastric epithelium. | gastric mucosa obtained from the body and pyloric portions of the human stomach were observed by light and transmission electron microscopy. ciliated cells were found in two of 18 subjects examined, one patient with gastric ulcer and the other one with gastric adenocarcinoma. the ciliated cells were found in epithelia at sites away from the main lesions. the tissues containing ciliated cells showed intestinal metaplasia combined with mild chronic gastritis in both cases. the epithelial layer fac ... | 1986 | 2876543 |
| quantitative evaluation of leukemic mitochondria with a computer-controlled image analyzer. | mitochondria from 25 patients with acute lymphoblastic leukemia (all) and 25 patients with acute myelogenous leukemia (aml) were compared in terms of their number, area, and shape index using a computer-controlled image analyzer. the number of mitochondria was greater in the aml than in the all patients. however, their size, as measured in electron micrographic profiles was similar in the two groups, in disagreement with conventional reports that mitochondria are small in granulocytes but large ... | 2010 | 2876544 |
| evidence for a migratory capability of rat kupffer cells to portal tracts and hepatic lymph nodes. | the present study concerns the migratory ability of kupffer cells in the rat. phagocytic cells were labeled with colloidal carbon or gold, these markers being administered intravenously either into a tail vein, which resulted in generalized reticuloendothelial uptake, or in low dose into the portal vein, which produced uptake by kupffer cells alone. cells containing marker were observed in the portal tracts and in hepatic lymph nodes from 1 to 3 days after injection into the portal vein. the dir ... | 1986 | 2876547 |
| selective adrenergic beta-2-receptor blocking drug, ici-118.551, is effective in essential tremor. | eighteen patients with essential tremor were treated for 2 days with a non-selective adrenergic beta-blocking drug (dl-propranolol, 80 mg x 3), a beta-2-selective blocker (ici-118.551, 50 mg x 3) and placebo (x 3) in a randomized double blind cross-over study. postural hand tremor was recorded with an accelerometer before administration of the drugs and at the end of each treatment period. compared with placebo, both the beta-blocking drugs caused a statistically significant decrease in tremor i ... | 2010 | 2876576 |
| coexistence of egg-laying hormone and alpha-bag cell peptide in bag cell neurons of aplysia indicates that they are a peptidergic multitransmitter system. | double-label immunocytochemistry reveals that immunoreactivity for two putative peptide transmitters, egg-laying hormone and alpha-bag cell peptide, co-exist in most bag cell somata and processes in the abdominal ganglion of the marine mollusc aplysia. together with previous physiological and biochemical data these findings indicate that the neuroendocrine bag cells are a multitransmitter system which utilizes two or more peptides derived from a common precursor. | 2010 | 2877421 |
| cross-linking site in fibrinogen for alpha 2-plasmin inhibitor. | a plasma proteinase inhibitor, alpha 2-plasmin inhibitor (alpha 2pi), is cross-linked with alpha chain of fibrin(ogen) by activated coagulation factor xiii (plasma transglutaminase). alpha 2pi serves only as a glutamine substrate (amine acceptor) for activated factor xiii in the cross-linking reaction, and the cross-linking occurs between gln-2 of the alpha 2pi molecule and a lysine residue (amine donor) of fibrin(ogen) alpha chain, whose position was investigated. alpha 2pi and fibrinogen were ... | 2010 | 2877981 |
| 6,7-dichloro-1-(3,4,5-trimethoxybenzyl)-1,2,3,4-tetrahydroisoquinoline . a structurally novel beta-adrenergic receptor blocking agent. | replacement of the catecholic hydroxyl groups of the beta-adrenergic receptor agonist 6,7-dihydroxy-1-(3,4,5-trimethoxybenzyl)-1,2,3,4-tetrahydroisoquinoline (trimetoquinol) with chloro substituents results in a compound with marked beta-adrenoceptor antagonist properties. this, therefore, parallels the similar transformation of the beta-adrenoreceptor agonist isoproterenol into the antagonist dichloroisoproterenol. in a test for inhibition of isoproterenol-induced enhancement of the rate of con ... | 1986 | 2878080 |
| phenotypic modification of human glioma and non-small cell lung carcinoma by glucocorticoids and other agents. | glucocorticoids are cytostatic for human glioma grown at a high cell density in cell culture. the effect is not cytotoxic, appears to involve a modification of the cell surface, and has been detected with methyl prednisolone, dexamethasone, and beta-methasone. glucocorticoids were also found to reduce malignancy-associated properties (plasminogen activator and endothelial mitogenesis) and enhance differentiation (glutamyl synthetase activity and high affinity gaba uptake). cytostasis was also se ... | 1986 | 2879508 |
| plasma levels of gastrin, somatostatin, and cholecystokinin immunoreactivity during pregnancy and lactation in dogs. | plasma levels of gastrinlike, somatostatinlike, and cholecystokininlike immunoreactivity were determined by radioimmunoassay in peripheral blood from 11 beagles during pregnancy and in response to suckling during lactation. cholecystokinin was determined in pooled and in individual plasma samples after separation of cholecystokinin and gastrin by high-performance liquid chromatography. gastrin and somatostatin levels were significantly increased during the 8-wk-long dog pregnancy; peak values we ... | 1987 | 2880780 |
| media for isolating shigella. | 1987 | 2881104 | |
| reticulocyte numbers in japanese quail chicks. | erythrocyte parameters in coturnix coturnix japonica were evaluated daily during the first 2 weeks after hatching. nadirs in total circulating erythrocyte numbers, hematocrit percentages, and hemoglobin concentrations were found during the first 5 days posthatch. reticulocytosis from 4 to 9 days posthatch ameliorated these nadirs until 12 days posthatch, when secondary nadirs appeared. erythropoiesis was indicated by reticulocytosis when hemoglobin levels decreased. reticulocyte maturation was i ... | 2010 | 2881700 |
| differences in adhesiveness among type 1 fimbriate strains of enterobacteriaceae revealed by an in vitro hep2 cell adhesion model. | ten type 1 fimbriate strains of enterobacteriaceae were examined in an in vitro adhesion assay with hep2 epithelial cells. the range of hep2 cell adhesiveness, which was characteristic for each strain, was affected by motility, type 1 fimbriation and production of mannose sensitive haemagglutinin. nevertheless, not all type 1 fimbriate strains adhered well in this model. the findings are discussed with regard to the possibility that different type 1 fimbriate enterobacteria, though all are manno ... | 1986 | 2881915 |
| damages for stillborn child. | 2009 | 2882128 | |
| antagonism of vecuronium and atracurium: comparison of neostigmine and edrophonium administered at 5% twitch height recovery. | in 39 healthy patients antagonism, by neostigmine 0.07 mg kg-1 or edrophonium 0.8 mg kg-1, of neuromuscular blockade induced by vecuronium or atracurium, was compared. reversal was attempted when the height of the single twitch (th) had recovered spontaneously to 5% of the control value. the evoked responses, initially single twitch, then train-of-four (tof) were observed until the tof ratio was 70%. induced recovery from th 5% to 25% was shorter following edrophonium than following neostigmine ... | 2010 | 2882769 |
| bw a575c, a chemically novel agent with angiotensin converting enzyme inhibitor and beta-adrenoceptor-blocking properties. | bw a575c (n-(1-(s)-carboxy-5-[4(3-isopropylamino-2-(r, s)-hydroxypropoxy)indole-2- carboxamido]pentyl)-(r, s)-alanyl-(s)-proline) is a chemically novel agent which exhibits in a single molecule both angiotensin converting enzyme (ace) inhibition and beta-adrenoceptor-blocking properties. bw a575c produced a competitive blockade of heart rate responses to isoprenaline in a guinea-pig right atrial preparation (pkb 7.18 +/- 0.05, cf. pindolol 8.9 +/- 0.7). bw a575c inhibited a partially purified pr ... | 1987 | 2882805 |
| glutathione metabolizing enzyme activities in human thyroid. | glutathione peroxidases, glutathione transferase, glutathione reductase and gamma-glutamyl transpeptidase activities were analyzed in human thyroid tissues obtained from 17 patients undergoing resectional surgery because of a malignancy. it was deduced, from measurements of glutathione peroxidase activity with both h202 and cumene hydroperoxide, that thyroid contains only the selenium enzyme. the absence of selenium independent glutathione peroxidase activity in thyroid was confirmed with gel fi ... | 1987 | 2883074 |
| [effect of music on the general feeling of persons performing monotonous work]. | the investigation was aimed at checking the influence of music on subjective symptoms of workers carrying out monotonous work. the investigation was divided into two stages: without music and with music. the investigation covered 80 women employed as electronic equipment fitters, mean age 26.5, and average length of employment 4 years. the scale of subjective appraisal of general feeling was applied. music transmitted at monotonous workplaces was found to eliminate of considerably decrease the i ... | 2010 | 2883554 |
| a competitive receptor binding radioassay for beta-1 and beta-2 adrenergic agents. | a rapid and sensitive competitive receptor binding assay for beta-1 and beta-2 adrenergic binding for adrenergic agents has been developed. the steps that are critical for the success of the assay are given in detail so that the assay can be set up in any routine laboratory with relative ease. the rationale behind the use of specific reagents is discussed. the assay requires microgram quantities of test compound, a radiolabeled specific beta adrenergic antagonist [3h]dihydroalprenolol (dha), and ... | 1987 | 2883662 |
| effects of age, duration and treatment of insulin-dependent diabetes mellitus on residual beta-cell function: observations during eligibility testing for the diabetes control and complications trial (dcct). the dcct research group. | to examine the effects of age and duration and treatment of insulin-dependent diabetes (iddm) on residual beta-cell function, we measured the fasting and sustacal-stimulated serum c-peptide levels in 610 conventionally treated iddm patients (age, 13-39 yr; duration of diabetes, 1-15 yr) during eligibility screening for the diabetes control and complications trial (dcct). fasting and stimulated c-peptide values were closely correlated (r = 0.83; p less than 0.001), and both declined with increasi ... | 2010 | 2884229 |
| effect of isotretinoin on survival of patients with myelodysplastic syndrome. | 2010 | 2884408 | |
| exposure to benzodiazepines in utero. | 2010 | 2884529 | |
| anti-surface antibodies to entamoeba histolytica and their role in complement lysis. | 1986 | 2884957 | |
| toward an integrated approach to the treatment of schizophrenia. | long-term outcome studies have shown that schizophrenia is an illness whose course is usually characterized by exacerbations and remissions. this chapter summarizes pertinent literature regarding treatment of acute episodes; early intervention to prevent the development of full relapse; and pharmacological, behavioral, and psychotherapeutic strategies designed to decrease the amount of stress and patients' vulnerability to stress and thus decrease the likelihood of relapse. an emphasis is placed ... | 2010 | 2885894 |
| pancreatic apudomas. | 2006 | 2885951 | |
| beta-blockade reverses regional dysfunction in ischemic myocardium. | to determine the protective effect of oxprenolol-induced beta-blockade on the compromised myocardium (critical constriction of the left anterior descending coronary artery) against the adverse effect of high concentrations of halothane, halothane dose-response curves were obtained in six dogs in each of three phases: preconstriction (control), critical constriction, and critical constriction with the addition of 0.3 mg/kg intravenous oxprenolol. the extent of depression of ventricular function w ... | 1987 | 2886076 |
| composite effects of actinonin when inhibiting enkephalin-degrading enzymes. | actinonin which has been found to be an inhibitor of aminopeptidase m (ec 3.4.11.2) also inhibited enkephalinase a (ec 3.4.24.11) and enkephalin aminopeptidase which were partially purified from the corpus striatum membrane of guinea-pig brain. the ic50 values were 5.6 microm for enkephalinase a and 0.39 microm for enkephalin aminopeptidase. actinonin also inhibited with an ic50 value of 1.1 microm dipeptidyl aminopeptidase tested on whole brain homogenate of rats in the presence of thiorphan an ... | 1987 | 2886348 |
| carrier detection of haemophilia a using dna markers in families with an isolated affected male. | the carrier status of women in five families with an isolated haemophilia male was assessed by pedigree analysis, coagulation factor assays and dna markers. in three families, ten women could be given very low risks of being carriers based on dna analysis. in two of the families the dna markers identified the mutation as originating in either the maternal or maternal grandfather's germ cell. combined dna and coagulation data suggested that the affected male in a third family was a de novo mutati ... | 2010 | 2887317 |
| azodisalicylate (azodisal sodium) causes intestinal secretion. comparative study of the effect of azodisalicylate, sulfasalazine, 5-aminosalicylic acid and sulfapyridine on the water and electrolyte transfer and the morphology of the rat ileum and colon in vivo. | azodisalicylate (ads) is one of the possible successors of sulfasalazine in the treatment of ulcerative colitis. the following results were obtained when comparing the influence of ads on net water and electrolyte transfer in tied-off loops of the rat ileum and colon in vivo with sulfsalazine, 5-aminosalicylic acid, and sulfapyridine. (1) sulfasalazine, 5-aminosalicylic acid and sulfapyridine had no effect on water and electrolyte transfer of the healthy intestinal mucosa in concentrations up to ... | 1987 | 2887473 |
| congenital adrenal hyperplasia. | 2010 | 2887945 | |
| activation of a common effector system by different brain neurotransmitter receptors in xenopus oocytes. | xenopus oocytes possess 'native' muscarinic receptors, which give rise to oscillatory chloride currents; similar responses are elicited by activation of foreign receptors to serotonin, glutamate and noradrenaline, expressed in oocytes after injection of messenger rna from rat brain. when low concentrations of two agonists are applied together, the combined response is greater than would be expected from the sum of the responses to each agonist applied alone. potentiation of acetylcholine by sero ... | 1987 | 2888117 |
| airway responsiveness in infancy. | 2009 | 2889415 | |
| dual action of excitatory amino acids on the metabolism of inositol phosphates in striatal neurons. | glutamate is able to stimulate inositol phosphate (ip) formation in striatal neurons in primary culture, mainly via an excitatory amino acid receptor of the quisqualate subtype. in the present study we show that carbachol (carb)-(a cholinergic agonist), but not neurotensin or norepinephrine-induced ip production could be reduced by 40% when measured in the presence of glu. the inhibition of the carb response by glu was dose dependent and reproduced by n-methyl-d-aspartate (nmda). quisqualate eli ... | 2010 | 2890092 |
| tardive dyskinesia. | 2010 | 2892565 | |
| why does placebo improve severe limb ischaemia? | 2010 | 2893161 | |
| bacterial diarrhoea and treatment. | 1988 | 2893218 | |
| arm exercise testing for coronary artery disease in patients with peripheral vascular disease. | we evaluated 74 peripheral vascular disease (pvd) patients (54 men, age 61 +/- 7 years and 17 women, age 63 +/- 7 years) for potential coronary heart disease (cad) using an arm exercise test (aet) protocol. all patients performed upright two-arm cranking using discontinuous stages of 2 minutes of exercise separated by 2 minutes of rest. exercise intensity was increased by +100 or 200 kpm (kilopond meters) with each stage. ecg was monitored continuously and blood pressure and 12-lead ecg tracings ... | 2010 | 2894261 |
| [the behavior of 1,4-benzodiazepine drugs in acidic media. ix. effect of hydrolyzate of flutazolam on the central nervous system]. | 2010 | 2894449 | |
| gastric bypass surgery as maternal risk factor for neural tube defects. | 2010 | 2894563 | |
| sex as a risk factor for htlv-i spread among intravenous drug abusers. | 1988 | 2895250 | |
| enhancement of contractile responses to partial alpha-adrenoceptor agonists during warming in rat aorta. | we examined the effects of warming on the contractile responses to full and partial alpha-adrenoceptor agonists in rat aorta. the contractions elicited by norepinephrine and methoxamine were not affected during warming (40 degrees c, 42 degrees c), whereas those induced by clonidine and st 587 were significantly enhanced. kcl-induced contractions of rat aorta were not affected by warming. the dissociation constants of clonidine and st 587 at 40 degrees c were not different from those at 37 degre ... | 1987 | 2895427 |
| direct effects of alpha 2-adrenergic receptor stimulation on intravascular systemic capacity in the dog. | the role of alpha 2-adrenergic receptor stimulation in the regulation of systemic vascular capacity and venous return, a major determinant of cardiac output, is not well understood. with the influence of the central nervous system isolated from the systemic circulation, the direct peripheral vascular effects of two specific, chemically distinct alpha 2-adrenergic receptor agonists, uk 14,304 and b-ht 920, were investigated in 19 dogs on total cardiopulmonary bypass with constant arterial perfusi ... | 1988 | 2895736 |
| the alpha 2-adrenoceptor agonists clonidine, tl99 and dpi enhance vasoconstrictor responses to sympathetic nerve stimulation and noradrenaline in the rat tail artery preparation. | 1. clonidine (1-30 nmol/l) enhanced the vasoconstrictor responses to sympathetic nerve stimulation in isolated perfused artery preparations from the rat tail. higher concentrations of clonidine produced vasoconstriction in most artery preparations and reduced the response to sympathetic nerve stimulation. 2. the enhancing effect of clonidine was not affected by prazosin but was blocked by idazoxan, indicating that it was due to activation of alpha 2-adrenoceptors. 3. the alpha 2-adrenoceptor ago ... | 1987 | 2896082 |
| human t-cell leukemia/lymphoma viruses: atl and aids. | 1985 | 2897327 | |
| relationship of free intracellular calcium to the cytolytic activity of entamoeba histolytica. | entamoeba histolytica adherence and destruction of host cells is required for in vivo pathogenicity; amebic in vitro adherence is mediated by a galactose- or n-acetyl-d-galactosamine-inhibitable surface lectin (gal/galnac adherence lectin). free intracellular ca2+ concentration [( ca2+]i) was measured in living amebae and target cells during amebic cytolysis of chinese hamster ovary (cho) cells and human polymorphonuclear neutrophils by utilizing the ca2+ probe fura-2 and computer-enhanced digit ... | 1988 | 2897335 |
| antimicrobial susceptibility of bordetella pertussis (part i). | in this review of the literature data are collected from the more recent studies on the susceptibility of bordetella pertussis to penicillins, cephalosporins, other beta-lactam antibiotics, aminoglycosides, tetracyclines, erythromycin, josamycin, co-trimoxazole and various other antibiotics. the methods of susceptibility testing of b. pertussis are discussed and suggestions for standardization are made. | 1988 | 2897337 |
| [endodontic approach to injured teeth]. | 2010 | 2897345 | |
| the high molecular weight receptor to transforming growth factor-beta contains glycosaminoglycan chains. | proteoglycans are constituents of the cell surface that may play important roles in the regulation of cell behavior. here we report that the 250-kda receptor subunit that binds the multifunctional protein, transforming growth factor-beta 1 (tgf-beta 1), contains chains of heparan sulfate and chondroitin sulfate and thus is a proteoglycan. digestion of tgf-beta 1-receptor complexes with glycosaminoglycan (gag)-specific degradative enzymes yield core proteins of 115-140 kda. cell monolayers that h ... | 1988 | 2897367 |
| a selective inhibitor of camp-specific phosphodiesterase, ro 20-1724, has no effect on the quantal release of acetylcholine from the mouse phrenic nerve. | the indirect twitch response of the mouse isolated phrenic nerve-diaphragm preparation, partially paralysed by tubocurarine, was restored only by about 10% by ro 20-1724 at 2 to 280 microm. the solvent vehicle, dimethylsulphoxide, also showed the same effect to a similar extent. intracellular recordings with glass microelectrodes revealed that ro 20-1724 (40 microm) affected neither the resting membrane potential, the amplitude and frequency of miniature endplate potentials nor the amplitude of ... | 1988 | 2897454 |
| [atypical variant of cushing's syndrome]. | 2010 | 2897495 | |
| apa i and sst i rflps at the insulin-like growth factor ii (igf2) locus on chromosome 11. | 1988 | 2897668 | |
| [bundle nailing--an evaluation after 27 years]. | the development of modern osteosynthetic procedures has made the use of bundle nailing uncommon. bundle nailing is restricted to extraordinary situations, but when indication is correct, it is superior to alternative procedures. from a current viewpoint only two indications remain: one are the fractures of the humeral shaft which cannot be treated conservatively, and the second are fractures of the femur in children if serious complications endanger conservative treatment. simple instruments and ... | 2010 | 2900592 |
| consent to aids testing. | 2010 | 2901644 | |
| human herpesvirus 6 and the henle-koch postulates. | 1988 | 2901654 | |
| molecular neurobiology--a conference sponsored by the nimh. | 2010 | 2902686 | |
| magnetic resonance imaging and early diagnosis of multiple sclerosis. | 2010 | 2903418 | |
| [genetic counseling in ornithine carbamoyltransferase deficiency]. | ornithine transcarbamylase (otc) deficiency is an inborn error of urea cycle metabolism, responsible for lethal hyperammonemia in males and for severe symptoms in at least 20% of heterozygous females. the authors provide here additional data on the informativity of the protein loading test (plt) for the detection of heterozygotes. they show that the risk of being a carrier for the mother of an affected boy falls from 2/3 a priori to only 1/8 if her plt is negative. the risk for the mother of het ... | 2010 | 2903704 |
| the organization of the cholinergic synapse. | 2010 | 2904504 | |
| interaction between anti-influenza viral polymerase antibodies and rnp particles using the in vitro transcription process and an immunogold labelling technique. | immunogold labelling and in vitro transcription of influenza virus vrna have been used to analyse the interaction of anti-influenza polymerase antibodies with influenza-ribonucleoprotein (rnp) complexes. the polymerase proteins (p proteins) were localized exclusively at one end of the rnp segments. in the course of transcription the amount of p protein decreased significantly. the in vitro transcriptase activity y of influenza a virus rnp complexes in the presence of anti-polymerase antibodies t ... | 1988 | 2904734 |
| blockade of spinal pathways decreases pre- and postganglionic discharge differentially. | although discharge of many sympathetic nerves decreases substantially on transection of the spinal cord in cats, firing of splenic and mesenteric postganglionic nerves continues unabated (r. l. meckler and l. c. weaver, brain res. 338: 123-135, 1985; r. d. stein and l. c. weaver. j. physiol. lond. 396: 155-172, 1988). therefore, ongoing sympathetic outflow directed to the splanchnic circulation was proposed to be less dependent on supraspinal excitatory drive than that directed to other vascular ... | 1988 | 2904774 |
| pharmacological properties of the positive inotropic and alpha 1-adrenoceptor blocking agent saterinone. | the pharmacological properties of saterinone [+/-)-1,2-dihydro-5-[4-[2-hydroxy-3-[4-(2-methoxyphenyl)-1-piperazinyl] propoxy]phenyl]-6-methyl-2-oxo-3-pyridine-carbonitrile, bdf 8634) were investigated in isolated organs of the guinea pig and in human platelets. saterinone was found to be a potent antagonist at vascular alpha 1-adrenoceptors with a pa2-value of 8.46 +/- 0.12. besides its affinity for alpha 1-adrenoceptors saterinone exerted a positive inotropic effect in the isolated papillary mu ... | 1988 | 2906245 |
| [effects of prazosin, sgb-1534, dobutamine and isoproterenol on congestive heart failure in dogs]. | effects of prazosin, dobutamine, isoproterenol and sgb-1534, a new alpha-blockade, on congestive heart failure (chf) in dogs were investigated. the model was made by protease injection into the left ventricular free wall, saline loading, and dextran and methoxamine infusions. by this maneuver, left atrial pressure (lap), systemic vascular resistance (svr) and left ventricular end-diastolic pressure (lvedp) were markedly increased, aortic blood flow (aobf) was decreased, and systemic blood pressu ... | 1988 | 2906315 |
| safety and efficacy of estrace (micronized 17 beta-estradiol). | 2010 | 2906339 | |
| malaria as anthropo-ecosystem. part i: general concept. | 1988 | 2906647 | |
| trials with portable screen rooms modified for use as animal-baited net traps for mosquito collection. | trials in larimer county, colorado during july and august 1984, with recreational screen rooms modified as large animal-baited mosquito traps are described. the two units tested are free-standing, portable and require no external support. in all-night trials, 462.5 mosquitoes/trap night were captured with horse bait compared with 367/trap night with cdc light traps. in 2-hour evening comparisons, mosquitoes collected per trapping period totalled 416 for horse-bait traps, 132 for light traps, and ... | 1985 | 2906667 |
| [the action of azepoxole on central alpha 2-adrenoreceptors]. | the effect of adrenomimetics on the central alpha 2-adrenoreceptors responsible for mydriasis was studied. it was found that alpha 2-adrenomimetic azepoxole (bht-933) exerts no effect on the central alpha 2-adrenoreceptors providing mydriasis. | 1988 | 2906881 |