Publications
| Title | Abstract | Year Filter | PMID(sorted ascending) Filter |
|---|
| accuracy of hpv testing of vaginal smear obtained with a novel self-sampling device. | most of women diagnosed as having cervical cancer have not participated in organized cytological screening. aim. a study was conducted to evaluate the accuracy of human papilloma virus testing by self-collected vaginal samples in comparison to regular cytological screening. the agreement of hybrid capture 2 assay and polymerase chain reaction assay for detection of human papilloma virus dna in self-collected vaginal samples and clinician-obtained cervical smears was investigated. | 2007 | 17230283 |
| the impact of preventive hpv vaccination. | the clearly defined causation by papillomavirus (hpv) and precursor lesions of cervical cancer have made this cancer largely preventable through pap screening programs, and now by vaccination with gardasil. this represents an important public health success story and here the authors summarize the potential impact of preventive hpv vaccination and some of the outstanding questions. | 2006 | 17234138 |
| amino acid substitution polymorphisms of the dna repair gene mgmt and the susceptibility to cervical carcinoma. | in the current study, we examined the association between polymorphisms in the o(6)-methylguanine-dna methyltransferase gene (mgmt) and the risk for cervical carcinoma. we prospectively selected 1012 patients, including 539 with carcinoma and 473 with cervical intra-epithelial neoplasia and 800 healthy women from five hospitals in zhejiang province, china. three single-nucleotide polymorphisms (leu84phe, ile143val and lys178arg) were genotyped, and their association with other epidemiological ri ... | 2007 | 17234722 |
| american cancer society guideline for human papillomavirus (hpv) vaccine use to prevent cervical cancer and its precursors. | the american cancer society (acs) has developed guidelines for the use of the prophylactic human papillomavirus (hpv) vaccine for the prevention of cervical intraepithelial neoplasia and cervical cancer. these recommendations are based on a formal review of the available evidence. they address the use of prophylactic hpv vaccines, including who should be vaccinated and at what age, as well as a summary of policy and implementation issues. implications for screening are also discussed. | 2007 | 17237032 |
| advocating for the quadravalent hpv vaccination, gardasil, by merck. | 2007 | 17239965 | |
| [vaccination against human papillomavirus infections]. | the aim of vaccination against human papillomaviruses is to fight against benign lesions as well as cancers. two vaccine strategies have been developed: therapeutic vaccines that induce cytotoxic t cells with the ability to eliminate infected/tumoral cells, and prophylactic vaccines that induce the production of neutralizing antibodies preventing hpv to infect their target cells. while the therapeutic strategies give good results in mouse model, their efficiency in human remains to be demonstrat ... | 2006 | 17243390 |
| risk factors and histological outcome of abnormal cervix with human papilloma infection in northeastern thai-women. | this study aimed to investigate the histological outcome of cervix with human papillomavirus (hpv) infection and the association of risk factors with cervical intraepithelial neoplasia (cin) and invasive cervical carcinoma (icc) development in northeast thai women. the study population (n=210) comprised 71 cases of normal cervix, 71 cases of cin and 68 cases of icc. the histological outcome of hpv infection was determined for 9.5% of the study population. increased risk factors for cin were obse ... | 2006 | 17250428 |
| effects of cidofovir on a novel cell-based test system for recurrent respiratory papillomatosis. | cidofovir has been reported to have activity against human papillomavirus (hpv) type 16, but no laboratory studies have been performed on hpv type 6, the main cause of recurrent respiratory papillomatosis (rrp). | 2007 | 17252592 |
| acceptance of human papillomavirus vaccination among californian parents of daughters: a representative statewide analysis. | to examine likelihood of parental acceptance of human papillomavirus (hpv) vaccination for young adolescent girls, together with reasons for acceptance and nonacceptance. the ultimate goal of this research is to inform policy decisions and educational planning in this area. | 2007 | 17259050 |
| combining hpv and mib-1 tests reduces the number of colposcopies in women with equivocal cytology. | in this study the mib-1 immunostaining pattern as an index of cellular proliferation was analyzed in smears diagnosed as borderline dyskaryosis in order to establish whether the combination of human papillomavirus testing and mib-1 staining could resolve equivocal cytology. | 2006 | 17260227 |
| drug approvals. | 2007 | 17264794 | |
| [vaccination schedule of the spanish association of pediatrics: recommendations 2007]. | the vaccine advisory committee of the spanish association of pediatrics provides information on the new developments in vaccines that have taken place in 2006 and recommends certain modifications to the immunization schedule for 2007. to ensure early protection, the measles-mumps-rubella (mmr) vaccine booster dose should be administered when children start school (3-4 years). based on existing scientific evidence, the importance of universal heptavalent conjugate pneumococcal vaccination, as occ ... | 2007 | 17266854 |
| nfx1-123 and poly(a) binding proteins synergistically augment activation of telomerase in human papillomavirus type 16 e6-expressing cells. | overcoming senescence signals in somatic cells is critical to cellular immortalization and carcinogenesis. high-risk human papillomavirus (hpv) can immortalize epithelial cells in culture through degradation of the retinoblastoma protein by hpv e7 and activation of htert transcription, the catalytic subunit of telomerase, by the heterodimer hpv e6/e6-associated protein (e6ap). recent work in our laboratory identified a novel repressor of htert transcription, nfx1-91, which is targeted for ubiqui ... | 2007 | 17267499 |
| routine vaccines across the life span, 2007. | routine vaccines are listed on the recommended childhood and adolescent immunization schedule and the recommended adult immunization schedule published by the centers for disease control and prevention and reviewed and updated by the advisory committee on immunization practices. for these vaccines, we discuss the disease burden, rationale for vaccination, efficacy, adverse reactions, and recommendations. some new vaccines are discussed here (tdap and zoster), whereas others (rotavirus and human ... | 2007 | 17270108 |
| establishment and characterization of asian oral cancer cell lines as in vitro models to study a disease prevalent in asia. | we have established 3 cell lines orl-48, -115 and -136 from surgically resected specimens obtained from untreated primary human oral squamous cell carcinomas of the oral cavity. the in vitro growth characteristics, epithelial origin, in vitro anchorage independency, human papilloma-virus (hpv) infection, microsatellite instability status, karyotype and the status of various cell cycle regulators and gatekeepers of these cell lines were investigated. all 3 cell lines grew as monolayers with doubl ... | 2007 | 17273794 |
| lower red blood cell folate enhances the hpv-16-associated risk of cervical intraepithelial neoplasia. | we previously reported that higher circulating concentrations of folate are independently associated with a lower likelihood of becoming positive for high-risk human papillomaviruses (hr-hpvs) and of having a persistent hr-hpv infection and a greater likelihood of becoming hr-hpv negative (cancer res 2004;64:8788-93). in the present study conducted in the same study population, we tested whether circulating folate concentrations modify the risk of cervical intraepithelial neoplasia (cin) > or =2 ... | 2007 | 17276035 |
| human papillomavirus-16 dna methylation patterns support a causal association of the virus with oral squamous cell carcinomas. | infection with human papillomavirus-16 (hpv-16) is the cause of most anogenital carcinomas. this virus is also detected in about 20% of all head and neck squamous cell carcinomas. while there is strong evidence for a causal etiological role in the case of tonsillar carcinomas, causal association with malignant lesions of the oral cavity is not yet conclusive. our previous investigations of hpv-16 dna methylation in anogenital sites have identified hypermethylation of the l1 gene and part of the ... | 2007 | 17278110 |
| developing an hpv vaccine to prevent cervical cancer and genital warts. | the challenges of the journey from target identification through development of a prophylactic quadrivalent human papillomavirus (hpv) vaccine have been met in gardasil. cervical cancer is the second leading cause of cancer-related death in women worldwide. approximately 70% of cervical cancer is caused by infection with hpv types 16 and 18 and approximately 90% of genital warts are caused by hpv types 6 and 11. the quadrivalent hpv vaccine was generated by expression of the major capsid protein ... | 2007 | 17289220 |
| selective induction of apoptosis by leptomycin b in keratinocytes expressing hpv oncogenes. | human papillomavirus (hpv) infection is strongly associated with the development of anogenital neoplasia, particularly cervical cancer. it has been estimated that 99.7% of all cervical carcinomas are attributable to infection with hpv, and types 16 and 18 account for the vast majority of such cases. both of these 'high risk' hpv types encode the oncoproteins e6 and e7, which exert multiple effects on many proteins involved in cell-cycle regulation, including p53. the nuclear export protein inhib ... | 2007 | 17290384 |
| down-regulation of insulin-like growth factor binding protein-5 (igfbp-5): novel marker for cervical carcinogenesis. | to better understand the underlying pathways of cervical carcinogenesis, cdna microarray analysis was performed on 2 sets of squamous cell carcinomas (sccs) and their adjacent normal squamous epithelia. consistently altered expression was detected for 32 genes. real-time rt-pcr analysis was conducted on a selected subset of these genes (s100a2, gpc4, p72, igfbp-5, trim2 and nab2) for 14 additional sccs and 10 normal epithelia. this found that, of the 6 candidate genes, only the insulin-like grow ... | 2007 | 17290407 |
| virally mediated cervical cancer in the iatrogenically immunocompromised: applications for psychoneuroimmunology. | oncogenic or high-risk (hr) human papillomavirus (hpv) infection is implicated in the pathogenesis of a number of cancers, including cervical cancer. hpv infected individuals who are immunocompromised secondary to acquired (e.g., human immunodeficiency virus [hiv]) or iatrogenic (e.g., systemic lupus erythematosus [sle] patients and organ and hematopoeitic stem cell transplant recipients undergoing immunosuppressive therapy) immune deficiency are particularly at risk for hpv-initiated cervical n ... | 2007 | 17291716 |
| human papillomavirus subtype 16 is common in pakistani women with cervical carcinoma. | human papillomavirus (hpv) is recognized as a major causative agent for cervical carcinomas. based on their oncogenic potential, hpv subtypes have been divided into high- and low-risk. in pakistan, screening for hpv in female patients is not commonly practiced, and as a consequence, the degree of hpv prevalence and its correlation with cervical cancer is unknown. | 2007 | 17291804 |
| human papilloma virus (hpv) prophylactic vaccination: challenges for public health and implications for screening. | prophylactic vaccination against high risk human papilloma virus (hpv) 16 and 18 represents an exciting means of protection against hpv related malignancy. however, this strategy alone, even if there is a level of cross protection against other oncogenic viruses, cannot completely prevent cervical cancer. in some developed countries cervical screening programmes have reduced the incidence of invasive cervical cancer by up to 80% although this decline has now reached a plateau with current cancer ... | 2007 | 17292517 |
| human papillomavirus-like particles mediate functional delivery of plasmid dna to antigen presenting cells in vivo. | because recombinant empty viral capsids are potentially attractive vectors for gene therapy, here we examined the ability of human papillomavirus (hpv) virus-like particles (vlps) to mediate delivery and expression of dna plasmids in vitro and in vivo. vlp-mediated delivery and expression of a gfp reporter construct in vitro was found to be highly dependent upon the presence of full-length l2 protein within the vlps. similarly, expression of gfp and luciferase reporter plasmids in vivo was stron ... | 2007 | 17293010 |
| comprehensive analysis of 130 multicentric intraepithelial female lower genital tract lesions by hpv typing and p16 expression profile. | hpv associated cervical transformation is characterized by well-defined steps, including persistent hpv infection and deregulated oncogene expression. recent studies have suggested that a number of lower genital tract lesions are clonally related to cervical lesions. in the current study, hpv infections and oncogene expression were assessed in a large series of patients with multicentric lower genital tract disease to analyze the transformation steps in extracervical disease. | 2007 | 17294241 |
| increased expression of dyrk1a in hpv16 immortalized keratinocytes enable evasion of apoptosis. | immortalization is a critical event in virus-related oncogenesis. no enough information, however, is currently available to elucidate the changes that occur in cellular molecules during immortalization. to identify potential cellular markers or regulators involving in immortalization, a paired-cell model of primary foreskin keratinocytes (fk) and hpv16 immortalized foreskin keratinocytes were established. using mrna differential display, rt-pcr and northern blot methods, we have identified and c ... | 2007 | 17294446 |
| [inhibiting e7 oncogene in caski cells of cervical cancer by vector-based rna interference technique]. | to test of the effect of vector-based rna interference (rnai) technique on inhibiting hpv16e7 gene in caski cells of cervical cancer. | 2007 | 17294716 |
| clinical efficacy of human papillomavirus dna detection in urine from patients with various cervical lesions. | a considerable number of adult korean women avoid a pap smear due to fear and discomfort of the pelvic examination. a reliable but noninvasive and comfortable screening method would considerably increase the participation rate. to evaluate the clinical efficacy of urine-based human papillomavirus (hpv) detection by oligonucleotide microarray, the results of hpv test from matched cervical swab specimens were compared. hpv dna was detected in 70 of 100 cervical samples. hpv 16 was the most prevale ... | 2007 | 17297259 |
| evaluation of rna markers for early detection of cervical neoplasia in exfoliated cervical cells. | numerous molecular biomarkers have been suggested for early detection of cervical cancer, but their usefulness in routinely collected exfoliated cells remains uncertain. we used quantitative reverse transcription-pcr to evaluate expression of 40 candidate genes as markers for high-grade cervical intraepithelial neoplasia (cin) in exfoliated cervical cells collected at the time of colposcopy. samples from the 93 women with cin3 or cancer were compared with those from 186 women without disease mat ... | 2007 | 17301262 |
| [the dynamic process of of hpv16l1 nucleocytoplasmic transport]. | in order to analyse the role of nucleus location signal of human papillomavirus type 16 l1 protein (nlshpv16l1), the various truncated hpv 16 l1 protein were tagged by enhance green flurenscent protein (egfp). after the egfp gene and various truncated hpv16 l1 genes (hpv16 l1, hpv16l1 delta nls and nlshpv16l gene segment) were obtained, they were cloned into the baculovirus pfastbac-hb transfer vector to constructe the recombinanted pfb-egfp, pfb-egfp-hpv16l1, pfb-egfp-hpv16l1 delta nls and pfb- ... | 2006 | 17302154 |
| human papillomavirus vaccine: a new chance to prevent cervical cancer. | human papillomavirus (hpv) is a significant source of morbidity and mortality throughout the world and is the most common sexually transmitted infection in the united states. hpv is the primary etiologic agent of cervical cancer and dysplasia. thus, cervical cancer and other hpv-associated malignancies might be prevented or treated by hpv vaccines. recent research on the safety and efficacy of candidate prophylactic vaccines against hpv have shown very promising results, with nearly 100% efficac ... | 2007 | 17302188 |
| the full-length e1e4 protein of human papillomavirus type 18 modulates differentiation-dependent viral dna amplification and late gene expression. | activation of the productive phase of the human papillomavirus (hpv) life cycle in differentiated keratinocytes is coincident with high-level expression of e1e4 protein. to determine the role of e1e4 in the hpv replication cycle, we constructed hpv18 mutant genomes in which expression of the full-length e1e4 protein was abrogated. undifferentiated keratinocytes containing mutant genomes showed enhanced proliferation when compared to cells containing wildtype genomes, but there were no difference ... | 2007 | 17303206 |
| differential expression of periodontal ligament-specific markers and osteogenic differentiation in human papilloma virus 16-immortalized human gingival fibroblasts and periodontal ligament cells. | periodontal ligament cells and gingival fibroblasts are important in the remodeling of periodontal tissue, but human papilloma virus (hpv)16-immortalized cell lines derived from human periodontal ligament cells and gingival fibroblasts has not been characterized. the purpose of this study was to establish and differentially characterize the immortalized cell lines from gingival fibroblasts and periodontal ligament by hpv16 transfection. | 2007 | 17305867 |
| differentially expressed genes between high-risk human papillomavirus types in human cervical cancer cells. | cervical carcinoma (cc) is one of the most common cancers among women worldwide and the first cause of death among the mexican female population. human papillomavirus (hpv) infection is the most important etiologic factor for cc. of the oncogenic types, hpv16 and hpv18 are found in 60-70% of invasive ccs worldwide. hpv18 appears to be associated with a more aggressive form of cervical neoplasia than hpv16 infection. at present, there are no studies on differentially expressed cellular genes betw ... | 2007 | 17309674 |
| a virosomal immunization strategy against cervical cancer and pre-malignant cervical disease. | in this study, we demonstrate that fusion-active virosomes, containing recombinant human papillomavirus type 16 (hpv16) e7 protein antigen, are capable of inducing a robust class i mhc-restricted cytotoxic t-lymphocyte (ctl) response against hpv-transformed tumour cells in a murine model system. virosomes are reconstituted viral envelopes, which do not contain the genetic material of the native virus. during the reconstitution process, protein antigens can be encapsulated within the virosomes. i ... | 2006 | 17310816 |
| hpv16 e6 variants and hla class ii polymorphism among chinese women with cervical cancer. | infection with human papillomavirus type 16 (hpv16) confers a high risk for the development of cervical cancer. variants of this virus may interact differentially with host genetic factors, possibly affecting the disease pathogenesis. this study was designed to investigate the association between hpv16 e6 variants and human leukocyte antigen (hla) polymorphism within a chinese population. peripheral blood from hpv16 positive chinese women with cervical carcinoma, who had previously been tested f ... | 2007 | 17311339 |
| human papillomavirus infection: the role of vaccination in pediatric patients. | human papillomavirus (hpv) infection is the most common sexually transmitted infection among adolescents and adults in the united states. given the prevalence of this infection and its relationship with the development of cervical cancer, hpv vaccine development has been a major public health initiative in the last decade. despite extensive research in the development of these vaccines, there remain many unanswered questions in academic and public arenas regarding their administration and role i ... | 2007 | 17314926 |
| notch1 induces cell cycle arrest and apoptosis in human cervical cancer cells: involvement of nuclear factor kappa b inhibition. | notch signaling can serve as a tumor suppressor or tumor promoter in the same kind of cancer, such as human papillomavirus-positive cervical cancer cells. however, the exact mechanisms remain poorly characterized. our studies demonstrated that constitutively overexpressed active notch1 via stable transfection with exogenous intracellular domain of notch1 (icn) resulted in growth inhibition of the human cervical cancer cell line hela by inducing g(2)-m arrest and apoptosis. moreover, the growth i ... | 2007 | 17316355 |
| human papillomavirus genotyping using hpv dna chip analysis in korean women. | this study was designed to investigate the genotypes of human papillomavirus (hpv) in korean women who had abnormal cervical cytology and to evaluate the clinical accuracy of hpv dna chip analysis for the diagnosis of cervical neoplasia. liquid-based cytology preparations, hpv dna chip analysis, and cervical biopsy were performed in 2358 women. high-risk hpv was identified in 23.5% of 1650 histologically confirmed normal samples (including cervicitis and squamous metaplasia) and in 81.8% of 708 ... | 2007 | 17316356 |
| two new vaccines: gardasil and rotateq. | 2007 | 17319292 | |
| activated b cells mediate efficient expansion of rare antigen-specific t cells. | potent professional antigen-presenting cells (apc) are essential tools to activate and expand antigen-specific t cells in vitro for use in adoptive immunotherapy. cd40-activated b cells can be easily generated and propagated from human donors and have been successfully used to generate antigen-specific t-cell cultures. here we show that cd40-activated b cells strongly and specifically expand rare populations of antigen-specific cd8 t cells, with frequencies of less than 1 in 20,000 cd8 t cells i ... | 2007 | 17321896 |
| human papillomavirus vaccine update. | with the approval of gardasil (merck and co., inc., whitehouse station, nj) in june of 2006 and the pending approval of cervarix (glaxosmithkline, london, uk), two prophylactic human papillomavirus (hpv) vaccines will be available for clinical use. randomized controlled trials have shown that both vaccines are safe and highly effective in preventing persistent infection and lesions caused by hpv 16 and 18--the types responsible for 70% of cervical cancers worldwide. determining an effective vacc ... | 2007 | 17324353 |
| deletion of a major neutralizing epitope of human papillomavirus type 16 virus-like particles. | human papillomavirus type 16 (hpv-16) is a major cause of human cancer. effective prophylactic vaccines are based on type-specific neutralizing antibodies. a major neutralizing epitope has been defined by the monoclonal antibody h16.v5. to investigate the importance of this epitope for overall immunogenicity of hpv-16, hpv-16 virus-like particles devoid of the h16.v5 epitope were engineered by site-directed mutagenesis of ten non-conserved, surface-exposed residues. removal of the h16.v5-defined ... | 2007 | 17325351 |
| jama patient page. human papillomavirus infection. | 2007 | 17327533 | |
| [tonsillar and oral cancer should be considered in the discussion on hpv vaccine]. | 2007 | 17328475 | |
| an extensive case of bowen's disease in an hiv-positive male. | bowen's disease is a form of squamous cell carcinoma in situ often associated with human papillomavirus (hpv). hpv has been hypothesized to cause in situ carcinoma via multiple mechanisms including cell immortalization and cell cycle disruption. coinfection with hiv is associated with greater risk of malignancy. we describe a case of hpv-associated bowen's disease in a 44-year-old african american male with sexually acquired hiv (cd4 < 20) who presented with an extensive skin lesion encompassing ... | 2007 | 17328656 |
| immunohistochemical detection of p16ink4a in liquid-based cytology specimens on cell block sections. | colposcopy biopsy procedure is a standard recommendation for atypical squamous cell cannot exclude high-grade lesion (asc-h) in abnormal papanicolaou smears. p16 (p16ink4a), a cell cycle regulator, has been shown to be overexpressed in squamous dysplasia. to further improve the diagnostic accuracy of the asc-h papanicolaou smear and to reduce unnecessary procedures, the authors evaluated the utility of immunodetection of p16 in liquid-based cytology specimens on cell blocks. | 2007 | 17330305 |
| multiple biomarkers in molecular oncology. i. molecular diagnostics applications in cervical cancer detection. | the screening for cervical carcinoma and its malignant precursors (cervical neoplasia) currently employs morphology-based detection methods (papanicolaou [pap] smear) in addition to the detection of high-risk human papillomavirus. the combination of the pap smear with human papillomavirus testing has achieved significant improvements in sensitivity for the detection of cervical disease. diagnosis of cervical neoplasia is dependent upon histology assessment of cervical biopsy specimens. attempts ... | 2007 | 17331061 |
| human papillomavirus: its identity and controversial role in oral oncogenesis, premalignant and malignant lesions (review). | human papillomaviruses (hpvs) are a group of host-specific dna viruses, with a remarkable epithelial cell specificity: they have been reported principally in the ano-genital tract, urethra, skin, larynx, tracheo-bronchial and oral mucosa. more than 100 different hpv types have been identified and classified as high (e.g. 16, 18, 31) or low (e.g. 11, 42, 36) -risk (hr and lr), based on their association with cervical carcinoma. the carcinogenic role of hr-hpv revolves mainly around two of its onc ... | 2007 | 17332919 |
| effect of selenium intake on the prevention of cutaneous epithelial lesions in organ transplant recipients. | organ graft recipients have a high rate of pre-malignant and malignant epithelial lesions. selenium directly influences the number of langer-hans cells. in several studies selenium has shown its role in preventing various carcinomas, it was worth investigating whether it could prevent skin cancer linked to human papilloma virus (hpv). a multicentre, randomised, placebo-controlled, parallel group study in 184 recent organ transplant recipients was undertaken. patients were treated for 3 years wit ... | 2007 | 17337398 |
| hpv vaccination - a paradigm shift in public health. | in 2006, the world's first quadrivalent human papillomavirus (hpv) vaccine (gardasil) was made available to the australian public. the quadrivalent hpv vaccine protects against cervical cancer, cervical abnormalities, and genital warts related to hpv types 6, 11, 16 and 18. general practitioners play a vital role in preventive medicine and as such should have a good understanding of the vaccine and its role in the primary prevention of cervical cancer and precancers. | 2007 | 17339969 |
| analysis of exon 2 of mts1 in hpv-positive and hpv-negative tumors of the head and neck region. | the aim of this study was to investigate the role of human papillomaviruses (hpvs) and alterations of p16ink4a in different squamous cell carcinomas (sccs) of the head and neck region by screening these carcinomas for alterations in exon 2 of p16ink4a and for hpv dna. a total of 42 samples of different sccs of the head and neck were collected by biopsy or surgical resection. after dna isolation, exon 2 of p16 was amplified and sequenced. hpv dna was detected by applying a broad-spectrum polymera ... | 2007 | 17340131 |
| high-risk hpv type-specific clearance rates in cervical screening. | we assessed clearance rates of 14 high-risk human papillomavirus (hrhpv) types in hrhpv-positive women with normal cytology and borderline/mild dyskaryosis (bmd) in a population-based cervical screening cohort of 44,102 women. the 6-month hrhpv type-specific clearance rates, that is, clearance of the same type as detected at baseline, in women with normal and bmd smears were 43% (95% confidence interval (ci) 39-47) and 29% (95% ci 24-34), respectively. corresponding 18-month clearance rates were ... | 2007 | 17342094 |
| who should get the hpv vaccine? | 2007 | 17343808 | |
| interim statement on hpv immunization. | 2007 | 17346478 | |
| vaccination against human papillomavirus. | 2006 | 17348095 | |
| superficial burns secondary to misuse of acetic acid solution. | topical use of acetic acid solutions is one of the treatments for human papillomavirus infections, although the disease can spontaneously resolve. over-the-counter availability of acetic acid solutions for medical use presents a potential hazard for misuse. here we present an example of accidental use. a 13-year-old boy was wounded as a result of using an acetic acid solution for cosmetic purposes. superficial burns on the left side of his face were managed with topical wound care, and minimal s ... | 2007 | 17351460 |
| six-month natural history of oral versus cervical human papillomavirus infection. | human papillomavirus (hpv) infection is etiologically associated with a subset of oral cancers, and yet, the natural history of oral hpv infection remains unexplored. the feasibility of studying oral hpv natural history was evaluated by collecting oral rinse samples on 2 occasions at a 6-month interval from 136 hiv-positive and 63 hiv-negative participants. cervical vaginal lavage samples were concurrently collected for comparison. hpv genomic dna was detected in oral and cervical samples by con ... | 2007 | 17354235 |
| risk of high-grade cervical intra-epithelial neoplasia based on cytology and high-risk hpv testing at baseline and at 6-months. | adding a test for high-risk human papillomavirus (hrhpv) to cytological screening enhances the detection of high-grade cervical intraepithelial neoplasia (>or=cin2), but data are required that enable long-term evaluation of screening. we investigated the >or=cin2 risk for women participating in population-based screening as a function of hrhpv and cytology testing results at baseline and at 6 months. we included 2,193 women aged 30-60 years participating in a population-based screening trial who ... | 2007 | 17354241 |
| dna vaccines encoding ii-padre generates potent padre-specific cd4+ t-cell immune responses and enhances vaccine potency. | it is now clear that cd4+ t cells play a crucial role in the generation of cd8+ t effector and memory t-cell immune responses. in this study, we enhanced the cd4+ t-cell immune responses in mice by constructing a dna vaccine encoding an invariant (ii) chain in which the class ii-associated ii peptide (clip) region is replaced with a cd4+ t-helper epitope, padre (ii-padre) (invariant pan hla-dr reactive epitope). c57bl/6 mice vaccinated with dna encoding ii-padre showed significantly greater padr ... | 2007 | 17356542 |
| p16ink4a expression, human papillomavirus, and survival in head and neck cancer. | development of head and neck cancer (hnc) is associated with human papillomavirus high-risk (hpv-hr) types. the hpv e7 oncoprotein inactivates the prb protein increasing expression of p16(ink4a). p16 expression and hpv status have been associated with differences in clinical outcomes for hnc. this study examined whether hnc prognosis was different when these biomarkers were examined as individual or joint molecular effects. tumor tissue from 301 hnc patients were analyzed and sequenced for hpv t ... | 2008 | 17360226 |
| human papillomavirus: cause of epithelial lacrimal sac neoplasia? | epithelial tumours of the lacrimal sac are rare but important entities that may carry grave prognoses. in this study the prevalence and possible role of human papillomavirus (hpv) infection in epithelial tumours of the lacrimal sac were evaluated. | 2007 | 17362365 |
| human papillomavirus testing by self-sampling: assessment of accuracy in an unsupervised clinical setting. | to compare the performance and acceptability of unsupervised self-sampling with clinician sampling for high-risk human papillomavirus (hpv) types for the first time in a uk screening setting. | 2007 | 17362570 |
| parental acceptance of human papillomavirus vaccines. | to determine whether parents would accept human papillomavirus (hpv) vaccination for their children and which variables may influence their decision, including knowledge about cervical cancer and hpv. | 2008 | 17368910 |
| giving patients information on abnormal cytology and human papillomavirus: survey of health providers. | knowledge of the link between hpv and cervical cancer is low among women. health providers may be required to give information and counseling on hpv. this study surveyed health providers' comfort in counseling women about hpv. | 2007 | 17375699 |
| quadrivalent human papillomavirus vaccine: recommendations of the advisory committee on immunization practices (acip). | these recommendations represent the first statement by the advisory committee on immunization practices (acip) on the use of a quadrivalent human papillomavirus (hpv) vaccine licensed by the u.s. food and drug administration on june 8, 2006. this report summarizes the epidemiology of hpv and associated diseases, describes the licensed hpv vaccine, and provides recommendations for its use for vaccination among females aged 9-26 years in the united states. genital hpv is the most common sexually t ... | 2007 | 17380109 |
| correlates of intent to be vaccinated against human papillomavirus: an exploratory study of college-aged women. | this study identified correlates of human papillomavirus (hpv) vaccine acceptance among college-aged women. data were collected by self-administered questionnaire. in multivariate analyses, women having vaginal sex (past 12 months) were nearly four times more likely to indicate acceptance (p = 0.0001). those reporting ever having a sexually transmissible infection (sti; p = 0.03) and those indicating ever having an abnormal pap test (p = 0.03) were more likely to indicate acceptance. thus, three ... | 2007 | 17382042 |
| unscheduled overexpression of human wapl promotes chromosomal instability. | previously, we have isolated and characterized a novel human gene termed human wapl that has the characteristics of an oncogene in uterine cervical cancer. wapl is inducible by human papillomavirus (hpv) e6 and e7 oncoproteins. on the other hand, recent studies have revealed that wapl regulates sister chromatid resolution by controlling the association of cohesin and chromatin. however, the effects of wapl overexpression on cervical carcinogenesis are still unclear. here, we show that wapl overe ... | 2007 | 17382297 |
| personal meaning of human papillomavirus and pap test results in adolescent and young adult women. | as new cervical cancer screening recommendations are adopted, more adolescents may learn they are infected with human papillomavirus (hpv). the objective of this study was to explore personal meaning of hpv and pap test results in adolescent and young adult women. | 2007 | 17385971 |
| biofunctional organic nanocrystals for quantitative detection of pathogen deoxyribonucleic acid. | advances in nanotechnology have had significant impacts in the field of biodiagnostics. in this study, we describe the novel application of dissolvable, organic and biofunctional nanocrystals for the quantitative detection of a pcr product. fluorescein diacetate (fda), a fluorogenic precursor of fluorescein, was milled in a solution of a polymeric surfactant to create a stable, nanosized colloid with an interface for coupling streptavidin molecules. the application of these particulate labels fo ... | 2007 | 17386578 |
| p53 codon 72 polymorphism, loss of heterozygosity and high-risk human papillomavirus infection in a low-incidence german esophageal squamous cell carcinoma patient cohort. | epidemiological studies in endemic geographic regions for esophageal squamous cell carcinoma (escc) suggested a number of risk factors, including modifications of the p53 tumor suppressor by codon arg72pro polymorphism, loss of heterozygosity (loh) or human papillomavirus type 16 or 18 (hpv 16/18) infection. the p53 arg72 variant has been suggested to be a high-risk factor in hpv-associated tumors. the present study analysed these associations in a low incidence geographic region in germany. fif ... | 2007 | 17390072 |
| vesicular stomatitis virus-based therapeutic vaccination targeted to the e1, e2, e6, and e7 proteins of cottontail rabbit papillomavirus. | persistent human papillomavirus (hpv)-associated benign and malignant lesions are a major cause of morbidity and mortality worldwide. vaccination against hpv early proteins could provide an effective means of treating individuals with established infections. recombinant vesicular stomatitis virus (vsv) vectors have been used previously to elicit strong humoral and cellular immune responses and develop prophylactic vaccines. we have shown that vsv vectors also can be used to elicit therapeutic im ... | 2007 | 17392369 |
| advances in primary and secondary interventions for cervical cancer: human papillomavirus prophylactic vaccines and testing. | cytologic screening has greatly reduced the incidence of invasive cervical cancer in many industrialized nations. state-of-the-art cervical cancer prevention is costly, however, and includes cytologic screening at repeat intervals, confirmation of abnormalities by colposcopic biopsy, and treatment of precancerous lesions. in resource-limited settings, accessibility to prevention programs for cervical cancer is often poor, or such programs are simply unavailable or inadequately supported. this di ... | 2007 | 17392713 |
| human papillomavirus subtypes are not uncommon. | while both variants and types of human papillomavirus (hpv) are common, subtypes (2-10% sequence divergence in the l1 gene) have been considered to be rare. we searched genbank and in-house databases using a 440 nt l1 fragment and identified 7, 30 and 10 subtypes/putative subtypes in the hpv genera alpha, beta and gamma, respectively. the number of types/putative types in each genus was 54, 58 and 103. thus, there appears to exist at least 47 different subtypes/putative subtypes of hpv and they ... | 2007 | 17395235 |
| genomic instability of the host cell induced by the human papillomavirus replication machinery. | development of invasive cervical cancer upon infection by 'high-risk' human papillomavirus (hpv) in humans is a stepwise process in which some of the initially episomal 'high-risk' type of hpvs (hr-hpvs) integrate randomly into the host cell genome. we show that hpv replication proteins e1 and e2 are capable of inducing overamplification of the genomic locus where hpv origin has been integrated. clonal analysis of the cells in which the replication from integrated hpv origin was induced showed e ... | 2007 | 17396148 |
| risk of cervical intraepithelial neoplasia grade 2 or 3 after loop electrosurgical excision procedure associated with human papillomavirus type 16 variants. | identification of factors associated with risk of relapse after treatment for high-grade cervical intraepithelial neoplasia (cin) has important clinical implications. study subjects were women participating in the atypical squamous cells of undetermined significance and low-grade squamous intraepithelial lesion triage study who were treated for cin3 by loop electrosurgical excision procedure (leep) and who had a baseline infection with human papillomavirus type 16 (hpv16). these women were follo ... | 2007 | 17397005 |
| human papillomavirus vaccine: the beginning of the end for cervical cancer. | the human papillomavirus family of viruses causes a variety of benign, premalignant and malignant lesions in men and women. all cervical cancers are caused by hpv. it is the leading cause of death from cancer in women in developing countries; every year some 493,000 women develop cervical cancer and 230,000 die every year from this disease. the vaccine against hpv includes virus-like particles, composed of the major viral capsid protein of hpv without the carcinogenic genetic core. large-scale s ... | 2007 | 17402325 |
| spontaneous tumor rejection by cbl-b-deficient cd8+ t cells. | the concept of tumor surveillance implies that specific and nonspecific components of the immune system eliminate tumors in the early phase of malignancy. understanding the biochemical mechanisms of tumor immunosurveillance is of paramount significance because it might allow one to specifically modulate spontaneous antitumor activity. we report that inactivation of the e3 ligase casitas b cell lymphoma-b (cbl-b) confers spontaneous in vivo rejection of tumor cells that express human papilloma vi ... | 2007 | 17403934 |
| human papillomavirus type distribution in invasive cervical cancer and high-grade cervical lesions: a meta-analysis update. | data on human papillomavirus (hpv) type distribution in invasive and pre-invasive cervical cancer is essential to predict the future impact of hpv16/18 vaccines and hpv-based screening tests. a meta-analyses of hpv type distribution in invasive cervical cancer (icc) and high-grade squamous intraepithelial lesions (hsil) identified a total of 14,595 and 7,094 cases, respectively. in icc, hpv16 was the most common, and hpv18 the second most common, type in all continents. combined hpv16/18 prevale ... | 2007 | 17405118 |
| clonality analysis and human papillomavirus infection in squamous metaplasia and atypical immature metaplasia of uterine cervix: is atypical immature metaplasia a precursor to cervical intraepithelial neoplasia 3? | atypical immature squamous metaplasia (ism) of the uterine cervix often has histological features that overlap with the histological characteristics of high-grade cervical intraepithelial neoplasia. to identify the cellular basis and clinical significance of atypical immature metaplasia (aim), 10 cases of aim were analyzed for the clonal status, and the presence of human papillomavirus (hpv) infection. the physical status of hpv was also evaluated in hpv type 16 (hpv-16)-positive cases. squamous ... | 2007 | 17413987 |
| insulin-like growth factor-i and risk of high-grade cervical intraepithelial neoplasia. | insulin-like growth factors (igf) and their binding proteins (igfbp) have been implicated in the risk of several epithelial or glandular tumors, including prostate cancer, breast cancer, and colon cancer. cervical cancer, which is also of epithelial origin, has been shown to overexpress receptors for igf-i, and plasma levels of igf-i have been positively associated with cervical cancer precursors in one epidemiologic study. in this case-control study, we investigated plasma levels of igf-i and i ... | 2007 | 17416762 |
| immunocompetency in children with recurrent respiratory papillomatosis: prospective study. | we sought to investigate the immunologic status of children with recurrent respiratory papillomatosis and to evaluate possible correlations between the patients' immunocompetency and the clinical course of the disease. | 2007 | 17419519 |
| evidence for a stem cell hierarchy in the adult human breast. | cellular pathways that contribute to adult human mammary gland architecture and lineages have not been previously described. in this study, we identify a candidate stem cell niche in ducts and zones containing progenitor cells in lobules. putative stem cells residing in ducts were essentially quiescent, whereas the progenitor cells in the lobules were more likely to be actively dividing. cells from ducts and lobules collected under the microscope were functionally characterized by colony formati ... | 2007 | 17420292 |
| thin-layer cytology: identification of human papillomavirus by hybridization, capture and signal amplification assay using an alcoholic cell preservative medium. | to ensure complete reliability in the detection of hyman papillomavirus using either specimen transport medium (digene inc., gaithersburg, maryland, u.s.a) or an alcoholic cell preservative. | 2007 | 17425201 |
| overexpressed active notch1 induces cell growth arrest of hela cervical carcinoma cells. | human cervical carcinoma is one of the most common malignant tumors, but the mechanisms that orchestrate the multiple oncogenic insults required for initiation and progression are not clear. notch signaling plays a critical role in maintaining the balance between cell proliferation, differentiation, and apoptosis, but perturbed notch signaling may contribute to tumorigenesis. we now show that notch1 is detected in all cervical cancer, including advanced diseases. we also constitutively overexpre ... | 2007 | 17425682 |
| photodynamic therapy-generated tumor cell lysates with cpg-oligodeoxynucleotide enhance immunotherapy efficacy in human papillomavirus 16 (e6/e7) immortalized tumor cells. | immunotherapy with photodynamic therapy (pdt) offers great promise as a new alternative for cancer treatment; however, its use remains experimental. in this study, we examined the immunotherapeutic significance of human papillomavirus (hpv)-immortalized tumor cell lysates induced by pdt with cpg-oligodeoxynucleotide (odn). pdt-cell lysates were generated by irradiating radachlorin (5 microg/ml) preloaded tc-1 cells carrying hpv 16 e7. pdt-cell lysates plus odn coinjection for protection against ... | 2007 | 17425690 |
| [cervix carcinoma--austrian vaccination committee recommends hpv vaccination]. | 2007 | 17427010 | |
| characterization and experimental transmission of an oncogenic papillomavirus in female macaques. | cervical cancer is one of the leading causes of cancer mortality in women worldwide, yet few suitable animal models currently exist for study of this disease. virtually all cases of cervical cancer in women are caused by specific types of genital human papillomavirus (hpv). in this study, we investigated naturally occurring genital pvs in female cynomolgus macaques (macaca fascicularis) without breeding contact for at least 3.5 years. exfoliated cervicovaginal cells from 19 of 54 animals tested ... | 2007 | 17428865 |
| [effect of nocardia rubra cell wall skeleton on the growth of hela cell line infected with hpv]. | to investigate the effects of nocardia rubra cell wall skeleton (nr-cws) on the hela cell line, one of the cell lines of human cervical cancer, infected with hpv. | 2007 | 17429525 |
| [association between human papillomavirus (hpv) type 16 infection and e6/e7 gene variant and the cervical lesions in beijing]. | to investigate the association between hpv16 infection, e6/e7 variations and the cervical lesions. | 2007 | 17429529 |
| prevalence and distribution of hpv genotypes among hiv-infected women in zambia. | we screened 145 hiv-infected non-pregnant women at a tertiary care centre in lusaka, zambia. liquid-based cytology and human papillomavirus (hpv) genotyping with pgmy09/11 biotinylated primers (roche linear array hpv genotyping test) maximised sensitivity of cytology and hpv assessments. among high-risk (hr) types, hpv 52 (37.2%), 58 (24.1%) and 53 (20.7%) were more common overall than hpv 16 (17.2%) and 18 (13.1%) in women with high-grade squamous intraepithelial lesions or squamous cell carcin ... | 2007 | 17437020 |
| translational mini-review series on vaccines: monitoring of human papillomavirus vaccination. | persistent infection with oncogenic human papillomavirus (hpv) is a necessary cause of cervical cancer. moreover, hpv type 16 (and to a lesser degree hpv type 18) is linked with more rare cancers, namely cancer of the vulva, vagina, penis, anus, oropharynx and larynx. effective prophylactic vaccines have been developed. in this review, we briefly address immunological aspects of hpv infection and the results of hpv vaccination trials. internationally standardized monitoring and evaluation of pro ... | 2007 | 17437418 |
| encapsidating artificial human papillomavirus-16 me7 protein in human papillomavirus-6b l1/l2 virus like particles.. | human papillomaviruses (hpvs) can infect squamous or mucosal epithelia and cause cervical cancer or genital warts. coinfection with multiple hpv types is a common finding of many epidemiological studies. therefore, it is necessary to develop a vaccine, which can eradicate established hpv infections and prevent other hpv infections. in this study, we generated chimeric virus like particles (cvlps) composed of hpv-6b l1, hpv-6b l2 and one artificial hpv-16 me7 proteins. | 2007 | 17439745 |
| the relationship of community biopsy-diagnosed cervical intraepithelial neoplasia grade 2 to the quality control pathology-reviewed diagnoses: an alts report. | we examined the predictors (cytologic interpretations, pathology review, human papillomavirus [hpv] testing results, and colposcopic impressions) of precancer among 545 women with clinical center biopsy diagnoses of cervical intraepithelial neoplasia (cin) 2 in the ascus lsil triage study. among women with a cin 2 biopsy result, there was an increasing likelihood that the loop electrosurgical excision procedure (leep) tissue sample was diagnosed as precancer (cin 3) with an increasing number of ... | 2007 | 17439841 |
| cyclooxygenase-2 transcription is regulated by human papillomavirus 16 e6 and e7 oncoproteins: evidence of a corepressor/coactivator exchange. | cyclooxygenase (cox-2) is overexpressed in human papillomavirus (hpv)-induced diseases, including cervical cancer. although hpv e6 and e7 oncoproteins have been causally linked to cervical carcinogenesis, their effects on cox-2 gene expression are unknown. increased levels of cox-2 mrna, protein, and prostaglandin e(2) synthesis were detected in hpv16 e6- and e7-expressing cervical cancer cells (caski and siha) compared with an uninfected cervical cancer cell line (c33a). hpv16 e6 and e7 oncopro ... | 2007 | 17440114 |
| [vaccination against human papillomaviridae. expert correspondence no. 18 of 29 december 2006]. | 2007 | 17440273 | |
| persistence of human papillomavirus as a predictor for treatment failure after loop electrosurgical excision procedure. | we aimed to investigate whether postconization human papillomavirus (hpv) dna testing can predict treatment failure and improve the accuracy of conventional follow-up in women with high-grade cervical intraepithelial neoplasia (cin). between march 2001 and october 2005, 120 patients with confirmed cin 2 or 3 were treated with loop electrosurgical excision procedure (leep) and were enrolled. six patients were lost to the follow-up. postconization follow-up was performed at every 3-6 months during ... | 2007 | 17442018 |
| unscheduled dna replication origin activation at inserted hpv 18 sequences in a hpv-18/myc amplicon. | oncogene amplification is a critical step leading to tumorigenesis, but the underlying mechanisms are still poorly understood. despite data suggesting that dna replication is a major source of genomic instability, little is known about replication origin usage and replication fork progression in rearranged regions. using a single dna molecule approach, we provide here the first study of replication kinetics on a previously characterized myc/papillomavirus (hpv18) amplicon in a cervical cancer. u ... | 2007 | 17444495 |
| case report of a kidney transplant recipient converted to everolimus due to malignancy: resolution of bronchiolitis obliterans organizing pneumonia without everolimus discontinuation. | the use of proliferative signal inhibitors (psis) in immunosuppression-related malignancies opens new roads for increasing the survival and quality of life in patients with solid organ transplantation. a 56-year-old female recipient of a living donor renal allograft (1990), who was immunosuppressed with cyclosporine (csa; neoral), azathioprine, and steroids, did initially well with acceptable renal function. during the last 5 years she required local therapy due to posterior vaginal lip human pa ... | 2007 | 17445552 |
| human papillomavirus in high- and low-risk areas of oesophageal squamous cell carcinoma in china. | to examine the potential roles of human papillomavirus (hpv) in oesophageal squamous cell carcinoma (escc) development, we examined the presence of hpv dna in paraffin-embedded escc tissues collected from two areas with different escc incidence rates in china, that is, gansu (n=26) and shandong (n=33), using pcr with spf10 primers, or pcr with gp5+/gp6+ primers combined with southern blot hybridisation. hpv genotype was determined by the inno-lipa hpv genotyping kit. hpv dna was detected in 17 c ... | 2007 | 17453003 |