Publications
| Title | Abstract | Year Filter | PMID(sorted ascending) Filter |
|---|
| vonoprazan-based helicobacter pylori eradication therapy: time to get kompetitive? | 2017 | 28776141 | |
| helicobacter pylori outer inflammatory protein a (oipa) suppresses apoptosis of ags gastric cells in vitro. | outer inflammatory protein a (oipa) is an important virulence factor associated with gastric cancer and ulcer development; however, the results have not been well established and turned out to be controversial. this study aims to elucidate the role of oipa in helicobacter pylori infection using clinical strains harbouring oipa "on" and "off" motifs. proteomics analysis was performed on ags cell pre-infection and postinfection with h. pylori oipa "on" and "off" strains, using liquid chromatograph ... | 2017 | 28776327 |
| upper gastrointestinal complications and cardiovascular/gastrointestinal risk calculator in patients with myocardial infarction treated with aspirin. | aspirin is widely used for the prevention of cardiovascular and cerebrovascular diseases for the past few years. however, much attention has been paid to the adverse effects associated with aspirin such as gastrointestinal bleeding. how to weigh the benefits and hazards? the current study aimed to assess the feasibility of a cardiovascular/gastrointestinal risk calculator, asariskcalculator, in predicting gastrointestinal events in chinese patients with myocardial infarction (mi), determining un ... | 2017 | 28776541 |
| editorial: replacing standard proton pump inhibitors with vonoprazan may breathe new life into triple therapy for helicobacter pylori-authors' reply. | 2017 | 28776746 | |
| editorial: replacing standard proton pump inhibitors with vonoprazan may breathe new life into triple therapy for helicobacter pylori. | 2017 | 28776748 | |
| inflammatory bowel diseases: review of known environmental protective and risk factors involved. | inflammatory bowel diseases consisting of crohn's disease and ulcerative colitis are chronic inflammatory diseases of the gastrointestinal tract. in addition to genetic susceptibility and disturbances of the microbiome, environmental exposures forming the exposome play an important role. starting at birth, the cumulative effect of different environmental exposures combined with a predetermined genetic susceptibility is thought to cause inflammatory bowel disease. all these environmental factors ... | 2017 | 28777099 |
| the effects of helicobacter pylori eradication on modification of metabolic syndrome parameters in patients with functional dyspepsia. | helicobactor pylori (h. pylori) have the potential role in the pathogenesis of various extra-gastric disorders such as metabolic disorders. but, it is now questioned about whether h. pylori eradication reduces or induces the risk for metabolic disorders especially in patients with dyspepsia. hence, the present study aimed to assess the effects of h. pylori eradication on criteria of metabolic syndrome. | 2017 | 28780229 |
| the association of helicobacter pylori with choroidal and retinal nerve fiber layer thickness. | to investigate the effect of helicobacter pylori (h. pylori) infection on choroidal thickness (ct) and retinal nerve fiber layer thickness (rnflt). | 2017 | 28780617 |
| efficacy and safety of rifaximin associated with standard triple therapy (omeprazole, clarithromycin and amoxicillin) for h. pylori eradication: a phase iv pilot clinical trial. | a progressive decrease in helicobacter pylori eradication rates has been described over the years, driving the need for new antibiotic treatments. | 2017 | 28780968 |
| primary antibiotic resistance in helicobacter pylori in the asia-pacific region: a systematic review and meta-analysis. | so far, a comprehensive systematic review and meta-analysis has not been done of the prevalence of primary antibiotic resistance in helicobacter pylori in the asia-pacific region. we aimed to assess the trends and regional differences in primary antibiotic resistance to h pylori in the asia-pacific region and to examine the relation between resistance and first-line eradication. | 2017 | 28781119 |
| time to change approaches to helicobacter pylori management. | 2017 | 28781120 | |
| management of adult primary immune thrombocytopenia based on japanese clinical guides. | primary immune thrombocytopenia (also known as idiopathic thrombocytopenic purpura; itp) is an autoimmune disorder characterized by isolated thrombocytopenia due to accelerated platelet destruction and impaired platelet production. the therapeutic goal of itp is not to normalize the platelet count, but to elevate the platelet count to a safe range (above 30×10(3)/µl) to minimize the risk of bleeding and to minimize the side effects of drugs such as corticosteroids and tpo receptor agonists (tpor ... | 2017 | 28781283 |
| structure-based design of ferritin nanoparticle immunogens displaying antigenic loops of neisseria gonorrhoeae. | effective vaccines are urgently needed to combat gonorrhea, a common sexually transmitted bacterial infection, for which treatment options are diminishing due to rapid emergence of antibiotic resistance. we have used a rational approach to the development of gonorrhea vaccines, and genetically engineered nanoparticles to present antigenic peptides of neisseria gonorrhoeae, the causative agent of gonorrhea. we hypothesized that the ferritin nanocage could be used as a platform to display an order ... | 2017 | 28781959 |
| systematic review with meta-analysis: diagnostic performance of the combination of pepsinogen, gastrin-17 and anti-helicobacter pylori antibodies serum assays for the diagnosis of atrophic gastritis. | the combination of pepsinogen, gastrin-17 and anti-h. pylori antibodies serological assays (panel test) is a non-invasive tool for the diagnosis of atrophic gastritis. however, the diagnostic reliability of this test is still uncertain. | 2017 | 28782119 |
| up-regulation of transient receptor potential vanilloid (trpv) and down-regulation of brain-derived neurotrophic factor (bdnf) expression in patients with functional dyspepsia (fd). | the role of immune activation in functional dyspepsia (fd) patients without previous infection is unclear. we compare the gastric and circulating brain-derived neurotropic factor (bdnf), receptor potential vanilloid type (trpv) families and various cytokines in fd patients. | 2017 | 28782273 |
| significance of dormant forms of helicobacter pylori in ulcerogenesis. | nearly half of the global population are carriers of helicobacter pylori (h. pylori), a gram-negative bacterium that persists in the healthy human stomach. h. pylori can be a pathogen and causes development of peptic ulcer disease in a certain state of the macroorganism. it is well established that h. pylori infection is the main cause of chronic gastritis and peptic ulcer disease (pud). decontamination of the gastric mucosa with various antibiotics leads to h. pylori elimination and longer remi ... | 2017 | 28785141 |
| management of helicobacter pylori infection: what should the surgeon know? | infection with helicobacter pylori continues to represent a major global health care burden, and various national and international consensus reports and guidelines have aimed at tracking recent developments for their translation into an optimized clinical management. the most important 'innovation' is the definition of h. pylori gastritis as an infectious disease. this does imply the consideration of therapy of this condition even before the development of clinical manifestations including non- ... | 2017 | 28785571 |
| gastric ulcer complications after the introduction of proton pump inhibitors into clinical routine: 20-year experience. | the aim of this study was to analyze the admissions and the management of peptic ulcer disease (pud) in a tertiary care surgical center. | 2017 | 28785572 |
| physiologic, pathophysiologic, and pharmacologic regulation of gastric acid secretion. | the present review summarizes the past year's literature, both clinical and basic science, regarding physiologic and pharmacologic regulation of gastric acid secretion in health and disease. | 2017 | 28787289 |
| decrease of estradiol and several lifestyle factors, but not helicobacter pylori infection, are significant risks for osteopenia in japanese females. | the primary cause of osteoporosis in women is increased bone resorption and decreased bone density associated with reduced estrogen secretion. several studies have demonstrated a relationship between helicobacter pylori infection and osteoporosis regardless of estrogen levels. this study examined the relationship between h. pylori infection and osteopenia together with estrogen levels, calcium intake, and several lifestyle factors. | 2017 | 28787719 |
| association between infection with h. pylori and atopy in young ethiopian children: a longitudinal study. | epidemiological evidence from developed countries indicates that helicobacter pylori infection correlates with a reduced risk of atopy and allergic disorders, however limited data are available from low-income countries. | 2017 | 28787771 |
| the middle fragment of helicobacter pylori caga induces actin rearrangement and triggers its own uptake into gastric epithelial cells. | cytotoxin-associated gene product a (caga) is a major virulence factor secreted by helicobacter pylori. caga activity in the gastric epithelium is associated with higher risk of gastric cancer development. bacterial type iv secretion system (t4ss)-mediated translocation of caga into the cytosol of human epithelial cells occurs via a poorly understood mechanism that requires caga interaction with the host membrane lipid phosphatidylserine (ps) and host cell receptor integrin α₅β₁. here we have ch ... | 2017 | 28788072 |
| histological transformation from gastric mucosa-associated lymphoid tissue lymphoma to gastric diffuse large b-cell lymphoma. | this study evaluated the clinical features, treatment and prognosis in chinese patients with histological transformation (ht) from gastric mucosa-associated lymphoid tissue lymphoma to gastric diffuse large b-cell lymphoma. we reviewed the medical records of 71 patients diagnosed with ht between 2001 and 2013, retrospectively. patients had a median age of 56 years. the ratio of sex (male:female) was 1.3:1. the clinical course was often insidious, lacking specific clinical presentation. macroscop ... | 2017 | 28789445 |
| the effect of psychological stress on mucosal il-6 and helicobacter pylori activity in functional dyspepsia. | pathophysiology of functional dyspepsia remains poorly understood. many factors such as gastric motility disorder, visceral hypersensitivity, helicobacter pylori (hp) infection, psychological stress and excessive gastric acid secretion play roles in this symptom. psychological stress may promote peptic ulcer and has an effect on ulcers-associated hp. this study aimed to determine helicobacter pylori activity and expression of mucosal il-6 and their association with psychological stress. | 2017 | 28790223 |
| functional dyspepsia with helicobacter pylori infection. | helicobacter pylori infection is commonly found worldwide. in indonesia, the prevalence of h. pylori infection is 22.1%. the bacteria are responsible for gastritis, peptic ulcer disease (pud), and gastric cancer.helicobacter pylori may also has a role in functional dyspepsia. diagnostic approach consists of noninvasive and invasive examinations. one of the invasive strategy is upper gastrointestinal (ugi) endoscopy and gastric mucosa biopsy. | 2017 | 28790233 |
| adding bismuth to rabeprazole-based first-line triple therapy does not improve the eradication of helicobacter pylori. | this randomized controlled study aimed to evaluate whether adding bismuth to the standard first-line triple therapy could improve the eradication rate of helicobacter pylori. a total of 162 patients with helicobacter pylori infection were randomly assigned to either the 7-day triple therapy group (rak regimen: rabeprazole 20 mg, amoxicillin 1 g, and clarithromycin 500 mg bid; n = 81) or the bismuth plus triple therapy group (n = 81). in the rbak group, bismuth subcitrate 360 mg twice daily was a ... | 2017 | 28791044 |
| comment on "effects of helicobacter pylori treatment on rosacea: a single-arm clinical trial study". | 2017 | 28791736 | |
| comment on "effects of helicobacter pylori treatment on rosacea: a single-arm clinical trial study". | 2017 | 28791740 | |
| reducing the flexibility of type ii dehydroquinase enzyme for inhibition - a fragment-based approach and molecular dynamics simulation study. | a multidisciplinary approach was used to identify and optimize a quinazolinedione-based ligand that would reduce the flexibility of the substrate-covering loop (catalytic loop) of the type ii dehydroquinase from helicobacter pylori. this enzyme, which is essential for the survival of this bacterium, is involved in the biosynthesis of the aromatic amino acids. a computer-aided fragment-based protocol (alta) was first employed to identify the aromatic fragments able to block the interface pocket t ... | 2017 | 28791799 |
| an evaluation of selected oral health indicators and cariogenic bacteria titer in patients with helicobacter pylori. | studies based on polymerase chain reaction (pcr) techniques indicate that helicobacter pylori can be constantly or temporarily present in the oral cavity in virulent or non-virulent form. streptococcus mutans exerts a strong inhibitory effect on h. pylori. | 2017 | 28791813 |
| frequency of infection with helicobacter pylori isolates of different antimicrobial profiles in children and adolescents: a preliminary study. | helicobacter pylori (h. pylori) infection can occur as a mixed infection caused by several strains of h. pylori. | 2017 | 28791844 |
| the study of memory and executive dysfunction in patients infected with helicobacter pylori. | background infectious agents are considered as potential causes of alzheimer's disease. recently, evidence of a high prevalence of helicobacter pylori (h. pylori) infection in patients with alzheimer's disease has been observed. the aim of this study was to investigate memory and executive function in h. pylori positive persons not suffering from alzheimer's or other marked cognitive disorders. methods this is a cross-sectional study. a total 140 participants were selected using purposive sampli ... | 2017 | 28791919 |
| aminophosphinates against helicobacter pylori ureolysis-biochemical and whole-cell inhibition characteristics. | urease is an important virulence factor from helicobacter pylori that enables bacterial colonization of human gastric mucosa. specific inhibition of urease activity can be regarded as a promising adjuvant strategy for eradication of this pathogen. a group of organophosphorus inhibitors of urease, namely, aminophosphinic acid and aminophosphonic acid derivatives, were evaluated in vitro against h. pylori urease. the kinetic characteristics of recombinant enzyme activity demonstrated a competitive ... | 2017 | 28792967 |
| helicobacter pylori infection and severity of coronary atherosclerosis in patients with chronic coronary artery disease. | controversy exists concerning the relation between helicobacter pylori (hp) infection and coronary artery disease (cad). we aimed to examine the relationship between hp infection and severity of coronary atherosclerosis in patients with chronic cad. | 2017 | 28794636 |
| berberine containing quadruple therapy for initial helicobacter pylori eradication: an open-label randomized phase iv trial. | due to increasing antimicrobial resistance, a bismuth-based quadruple regimen has been recommended as an alternative first-line therapy for helicobacter pylori (h pylori) eradication. however, different results are varied greatly and the availability of bismuth was limited in some countries. we assessed the efficacy and safety of 14-day berberine-containing quadruple therapy as an alternative regimen for h pylori eradication. | 2017 | 28796053 |
| enzymatic synthesis of n-acetyllactosamine (lacnac) type 1 oligomers and characterization as multivalent galectin ligands. | repeats of the disaccharide unit n-acetyllactosamine (lacnac) occur as type 1 (galβ1, 3glcnac) and type 2 (galβ1, 4glcnac) glycosylation motifs on glycoproteins and glycolipids. the lacnac motif acts as binding ligand for lectins and is involved in many biological recognition events. to the best of our knowledge, we present, for the first time, the synthesis of lacnac type 1 oligomers using recombinant β1,3-galactosyltransferase from escherichia coli and β1,3-n-acetylglucosaminyltranferase from ... | 2017 | 28796164 |
| yes, research matters. | my father was diagnosed with stomach cancer recently. luckily, it was still at an early stage, and endoscopic surgery successfully took care of it. my father was fortunate; since people with stomach cancer do not show clear symptoms in the early stages, the disease is often not diagnosed until it becomes advanced. in his case, the diagnosis started from a suggestion by his doctor to check whether he had a gastric infection with helicobacter pylori, a bacterial species found in the digestive trac ... | 2017 | 28796840 |
| two populations of less-virulent helicobacter pylori genotypes in bangladesh. | bangladesh has a population with a low gastric cancer risk but high prevalence of helicobacter pylori infection. several studies have examined virulence genes in h. pylori from bangladesh. we analyzed caga and vaca subtypes and their association with severe histology phenotypes, and analyzed population types among bangladeshi strains. we included patients who underwent endoscopy in dhaka. sequences of virulence genes and seven housekeeping genes were obtained by next generation sequencing and co ... | 2017 | 28797101 |
| marked improvement in gastric involvement in behçet's disease with adalimumab treatment. | gastric involvement is the least frequent manifestation of behçet's disease, and effective treatment for it unknown. here the case of a patient with gastric involvement in behçet's disease that was markedly improved with adalimumab therapy is presented. a 68-year-old man developed an oral ulcer, erythema, folliculitis, and arthralgia. behçet's disease was suspected; then, prednisolone and colchicine were administered. esophagogastroduodenoscopy showed a punched-out ulcer in the posterior wall of ... | 2017 | 28797990 |
| the characteristics and prognosis of diffuse-type early gastric cancer diagnosed during health check-ups. | because of the poor prognosis of diffuse-type gastric cancer, early detection is important. we investigated the clinical characteristics and prognosis of diffuse-type early gastric cancer (egc) diagnosed in subjects during health check-ups. | 2017 | 28798286 |
| the hypothesis that helicobacter pylori predisposes to alzheimer's disease is biologically plausible. | there is epidemiological evidence that h. pylori might predispose to alzheimer's disease. to understand the cellular processes potentially linking such unrelated events, we incubated the human gastric cells mnk-28 with the h. pylori peptide hp(2-20). we then monitored the activated genes by global gene expression. the peptide modulated 77 genes, of which 65 are listed in the alzbase database and include the hallmarks of alzheimer's disease: app, apoe, psen1, and psen2. a large fraction of modula ... | 2017 | 28798312 |
| helicobacter pylori infection and serum level of pepsinogen are associated with the risk of metachronous gastric neoplasm after endoscopic resection. | patients who have undergone endoscopic resection of early gastric cancers (egcs) are at risk for metachronous gastric neoplasm. | 2017 | 28799258 |
| upfront immunohistochemistry improves specificity of helicobacter pylori diagnosis. a french pathology laboratory point of view. | there is no consensus about the histopathologic methods to detect helicobacter pylori in gastric biopsies to date. we aimed to question about the value of upfront anti-h. pylori immunohistochemistry in this field. | 2017 | 28799687 |
| molecular basis for the functions of a bacterial muts2 in dna repair and recombination. | bacterial muts2 proteins, consisting of functional domains for atpase, dna-binding, and nuclease activities, play roles in dna recombination and repair. here we observe a mechanism for generating muts2 expression diversity in the human pathogen helicobacter pylori, and identify a unique muts2 domain responsible for specific dna-binding. h. pylori strains differ in muts2 expression due to variations in the dna upstream sequence containing short sequence repeats. based on western blots, muts2 in s ... | 2017 | 28800560 |
| multicentric randomised study of helicobacter pylori eradication and pepsinogen testing for prevention of gastric cancer mortality: the gistar study. | population-based eradication of helicobacter pylori has been suggested to be cost-effective and is recommended by international guidelines. however, the potential adverse effects of widespread antibiotic use that this would entail have not been sufficiently studied. an alternative way to decrease gastric cancer mortality is by non-invasive search for precancerous lesions, in particular gastric atrophy; pepsinogen tests are the best currently available alternative. the primary objective of gistar ... | 2017 | 28801429 |
| immune responses against helicobacter pylori-specific antigens differentiate relapsing remitting from secondary progressive multiple sclerosis. | to assess whether helicobacter pylori (hp) antibody (ab) reactivity against individual hp antigens is pathogenetically relevant to multiple sclerosis (ms), we systematically investigated prevalence and clinical significance of abs against 14 immunodominant and subdominant hp antigens by elisa and immunoblotting in 139 consecutive ms patients with relapsing-remitting (rrms, n = 102) or secondary progressive (spms, n = 37). sera from 39 patients with parkinson's disease (pd), 21 with alzheimer's d ... | 2017 | 28801580 |
| helicobacter pylori and its secreted immunomodulator vaca protect against anaphylaxis in experimental models of food allergy. | food allergy is an increasingly common health problem in western populations. epidemiological studies have suggested both positive and negative associations between food allergy and infection with the gastric bacterium helicobacter pylori. | 2017 | 28802077 |
| helicobacter pylori cytotoxin-associated gene a impairs the filtration barrier function of podocytes via p38 mapk signaling pathway. | helicobacter pylori (hp) specific antigens were found deposited in the glomeruli in some kidney diseases. however, the underlying molecular mechanisms remain to be elucidated. the aim of this study was to investigate the effect of cytotoxin associated gene a protein (caga), a key virulence factor of hp, on mouse podocytes. cells were cultured and treated with recombinant caga protein. the expression of the tight junction protein zo-1 and p38 mapk signaling pathway activation were measured with r ... | 2017 | 28803254 |
| nongenetically modified lactococcus lactis-adjuvanted vaccination enhanced innate immunity against helicobacter pylori. | gram-positive enhancer matrix particles (gem) produced by lactococcus lactis can enhance vaccine-induced immune response. however, the mechanism under which this adjuvant mounts the efficacy of orally administered vaccines remains unexplored. | 2017 | 28805287 |
| letter: helicobacter pylori in lean and obese patients with non-alcoholic fatty liver disease. | 2017 | 28805327 | |
| new clinical paradigms for treating and preventing antiplatelet gastrointestinal bleeding. | to quantify antiplatelet-related gastrointestinal bleeding (gib), characterize patients at greatest risk and summarize risk-management strategies emphasizing evolving knowledge in acute management of antiplatelet-related bleeding. | 2017 | 28806270 |
| second-line therapy for helicobacter pylori eradication causing antibiotic-associated hemorrhagic colitis. | helicobacter pylori (h. pylori) eradication rarely develops into antibiotic-associated hemorrhagic colitis (aahc), in which the etiology of colitis remains unclear. we herein report a rare case of aahc caused by second-line therapy for h. pylori eradication. | 2017 | 28806959 |
| both 14-day hybrid and bismuth quadruple therapies cure most patients with helicobacter pylori infection in populations with moderate antibiotic resistance: a randomized controlled trial. | background & aim: hybrid therapy is a novel two-step treatment achieving a high eradication rate for h. pylori infection. currently, whether this new therapy achieves a higher eradication rate than bismuth quadruple therapy remains an unanswered question. the aim of this prospective, randomized, comparive study was to investigate the efficacies of 14-day hybrid therapy and bismuth quadruple therapy in the treatment of h. pylori infection.methods: from july 2013 to june 2015, eligible h. pylori-i ... | 2017 | 28807915 |
| binding of the helicobacter pylori oipa causes apoptosis of host cells via modulation of bax/bcl-2 levels. | the h. pylori outer inflammatory protein a (oipa) is an outer membrane protein that contributes to gastric inflammation. oipa is believed to affect intra-cellular signalling and modulate the host signalling pathways. the aim of the current study was to clarify the role of oipa in h. pylori pathogenesis and its effect on host cell signalling pathways. to this end, the oipa gene was isolated and inserted into cloning and expression vectors. the recombinant plasmid was transferred into an expressio ... | 2017 | 28808292 |
| isolation of abscisic acid from korean acacia honey with anti-helicobacter pylori activity. | helicobacter pylori (h. pylori) is linked to the development of the majority of peptic ulcers and some types of gastric cancers, and its antibiotic resistance is currently found worldwide. | 2017 | 28808376 |
| structure-function analyses of metal-binding sites of hypa reveal residues important for hydrogenase maturation in helicobacter pylori. | the nickel-containing enzymes of helicobacter pylori, urease and hydrogenase, are essential for efficient colonization in the human stomach. the insertion of nickel into urease and hydrogenase is mediated by the accessory protein hypa. hypa contains an n-terminal nickel-binding site and a dynamic structural zinc-binding site. the coordination of nickel and zinc within hypa is known to be critical for urease maturation and activity. herein, we test the hydrogenase activity of a panel of h. pylori ... | 2017 | 28809946 |
| evolution of correlation between helicobacter pylori infection and autoimmune liver disease. | the present study was planned to evaluate correlation between helicobacter pylori (hp) infection and autoimmune liver disease (aild). a total of 60 patients diagnosed with aild in affiliated hospital of binzhou medical college were continuously enrolled in the present study. hp infection was detected by 13c-urea breath test. the levels of anti-myeloperoxidase were tested by elisa. the positive rate of anti-nuclear antibody (ana), anti-mitochondrial antibody (ama), anti-smooth muscle antibody (sm ... | 2017 | 28810614 |
| is there a link between clinical manifestation of gastric anisakiasis and helicobacter pylori infection? | 2017 | 28810728 | |
| tifa signaling in gastric epithelial cells initiates the cag type 4 secretion system-dependent innate immune response to helicobacter pylori infection. | helicobacter pylori is a bacterial pathogen that colonizes the human stomach, causing inflammation which, in some cases, leads to gastric ulcers and cancer. the clinical outcome of infection depends on a complex interplay of bacterial, host genetic, and environmental factors. although h. pylori is recognized by both the innate and adaptive immune systems, this rarely results in bacterial clearance. gastric epithelial cells are the first line of defense against h. pylori and alert the immune syst ... | 2017 | 28811347 |
| stromal r-spondin orchestrates gastric epithelial stem cells and gland homeostasis. | the constant regeneration of stomach epithelium is driven by long-lived stem cells, but the mechanism that regulates their turnover is not well understood. we have recently found that the gastric pathogen helicobacter pylori can activate gastric stem cells and increase epithelial turnover, while wnt signalling is known to be important for stem cell identity and epithelial regeneration in several tissues. here we find that antral wnt signalling, marked by the classic wnt target gene axin2, is lim ... | 2017 | 28813421 |
| the helicobacter pylori type iv secretion system promotes il-8 synthesis in a model of pediatric airway epithelium via p38 map kinase. | epidemiologic studies have reported an inverse relationship between childhood helicobacter pylori infection and development of allergic asthma. because lung epithelium plays an important role in allergic asthma pathogenesis, we hypothesized that h. pylori may directly influence airway epithelial cell innate immune function, particularly in early childhood. to test our hypothesis, we established an in vitro h. pylori infection model using primary tracheobronchial epithelial cell cultures derived ... | 2017 | 28813514 |
| may gender or ethnicity affect delta over baseline values obtained by 13-c urea breath test? | 13c-urea breath test (ubt) is a non-invasive test for detecting active h.pylori infection. previous studies showed a correlation of delta over baseline (dob) values with bacterial load, mucosal inflammation and successful eradication. gender has been shown to affect dob in children. aim of our study was to verify whether gender or ethnicity affects dob in adults. | 2017 | 28814259 |
| micromotor-enabled active drug delivery for in vivo treatment of stomach infection. | advances in bioinspired design principles and nanomaterials have led to tremendous progress in autonomously moving synthetic nano/micromotors with diverse functionalities in different environments. however, a significant gap remains in moving nano/micromotors from test tubes to living organisms for treating diseases with high efficacy. here we present the first, to our knowledge, in vivo therapeutic micromotors application for active drug delivery to treat gastric bacterial infection in a mouse ... | 2017 | 28814725 |
| antibiotic susceptibility, heteroresistance, and updated treatment strategies in helicobacter pylori infection. | in this review, we discuss the problem of antibiotic resistance, heteroresistance, the utility of cultures and antibiotic susceptibility tests in helicobacter pylori (hp) eradication, as well as the updated treatment strategies for this infection. the prevalence of antibiotic resistance is increasing all over the world, especially for metronidazole and clarithromycin, because of their heavy use in some geographical areas. heteroresistance (simultaneous presence of both susceptible and resistant ... | 2017 | 28814829 |
| prevalence and characteristics of epstein-barr virus-associated gastric carcinomas in portugal. | gastric cancer (gc) is one of the most common malignant tumors of the digestive tract and is the third leading cause of cancer death worldwide. epstein-barr virus (ebv) has been associated with approximately 10% of the total cases of gastric carcinomas. no previous study has analyzed the prevalence of ebv infection in gastric cancer of the portuguese population. | 2017 | 28814970 |
| helicobacter pylori infection, atrophic gastritis, and pancreatic cancer risk: a meta-analysis of prospective epidemiologic studies. | to investigate the associations of helicobacter pylori (hp) infection and atrophic gastritis (ag) with pancreatic cancer risk. | 2017 | 28816977 |
| effectiveness of helicobacter pylori eradication in the prevention of primary gastric cancer in healthy asymptomatic people: a systematic review and meta-analysis comparing risk ratio with risk difference. | helicobacter pylori infection is strongly associated with gastric cancer occurrence. however, it is unclear whether eradication therapy reduces the risk of gastric cancer occurrence. we evaluated whether h. pylori eradication reduces the risk of primary gastric cancer by using both risk ratio (rr) and risk difference (rd). | 2017 | 28817628 |
| mechanism of transformation in mycobacteria using a novel shockwave assisted technique driven by in-situ generated oxyhydrogen. | we present a novel method for shockwave-assisted bacterial transformation using a miniature oxyhydrogen detonation-driven shock tube. we have obtained transformation efficiencies of about 1.28 × 10(6), 1.7 × 10(6), 5 × 10(6), 1 × 10(5), 1 × 10(5) and 2 × 10(5) transformants/µg of dna for escherichia coli, salmonella typhimurum, pseudomonas aeruginosa, mycobacterium smegmatis, mycobacterium tuberculosis (mtb) and helicobacter pylori respectively using this method which are significantly higher th ... | 2017 | 28819202 |
| curcuma wenyujin y. h. chen et c. ling n-butyl alcohol extract inhibits ags cell helicobacter pylori caga+vaca+ promoted invasiveness by down-regulating caudal type homeobox transcription factor and claudin-2 expression. | to investigate the effects and possible mechanisms of action of curcuma wenyujin y. h. chen et c. ling n-butyl alcohol extract (cwnae) on repression of human gastric cancer (gc) ags cell invasion induced by co-culturing with helicobacter pylori (hp). | 2017 | 28819779 |
| different look in to the role of flagella in pathogenesis of helicobacter pylori. | 2017 | 28819884 | |
| detection of interactions between proteins by using legendre moments descriptor to extract discriminatory information embedded in pssm. | protein-protein interactions (ppis) play a very large part in most cellular processes. although a great deal of research has been devoted to detecting ppis through high-throughput technologies, these methods are clearly expensive and cumbersome. compared with the traditional experimental methods, computational methods have attracted much attention because of their good performance in detecting ppis. in our work, a novel computational method named as pcvm-lm is proposed which combines the probabi ... | 2017 | 28820478 |
| modifiable factors and esophageal cancer: a systematic review of published meta-analyses. | there are marked differences in the etiology of the major histological types of esophageal cancer (ec)-squamous cell carcinomas (escc) and adenocarcinomas (eac). this study aimed to summarize the current scientific knowledge on modifiable risk factors for ec, by histological type, through a systematic review of meta-analyses referenced in pubmed and isi web of knowledge. we identified 100 meta-analyses on risk factors for escc (n = 54), eac (n = 43), or ec (n = 51). escc risk significantly incre ... | 2017 | 28821981 |
| [influence of saccharomyces boulardii sachets combined with bismuth quadruple therapy for initial helicobacter pylori eradication]. | objective: to evaluate the efficacy and safety of saccharomyces boulardii sachets combined with bismuth quadruple therapy for initial helicobacter pylori(h.pylori) eradication. methods: from march 2014 to march 2015, 240 participants from the third hospital of hebei medical university with h. pylori infection were recruited and randomized into three groups: quadruple therapy group received bismuth potassium citrate 220 mg bid + rabeprazole 10 mg bid + amoxicillin 1 000 mg bid+ furazolidone 100 m ... | 2017 | 28822453 |
| identification of distinctive clinical significance in hospitalized patients with endoscopic duodenal mucosal lesions. | duodenitis is not infrequent finding in patient undergoing endoscopy. however, hospitalized patients have a higher incidence of secondary duodenal mucosal lesions that might be related with inflammatory bowel disease (ibd), cytomegalovirus (cmv) infection, tuberculosis, immunologic disorders, or other rare infections. we aimed to identify clinicopathologic features of duodenal mucosal lesions in hospitalized patients. | 2017 | 28823115 |
| microbes and viruses are bugging the gut in celiac disease. are they friends or foes? | the links between microorganisms/viruses and autoimmunity are complex and multidirectional. a huge number of studies demonstrated the triggering impact of microbes and viruses as the major environmental factors on the autoimmune and inflammatory diseases. however, growing evidences suggest that infectious agents can also play a protective role or even abrogate these processes. this protective crosstalk between microbes/viruses and us might represent a mutual beneficial equilibrium relationship b ... | 2017 | 28824555 |
| the exceptional oncogenicity of htlv-1. | human t-cell leukemia virus-1 (htlv-1) is the first pathogenic human retrovirus identified in 1979 by the gallo group. htlv-1 causes fatal t-cell leukemia (adult t cell leukemia) and a progressive myelopahy (htlv-1-associated myelopathy/ tropical spastic paraparesis, ham/tsp) and other disorders. since the discovery of htlv-1, several other microorganisms are demonstrated to cause cancer in humans. in this article, we investigated the oncogenic capacity of htlv-1, in comparison with those of oth ... | 2017 | 28824561 |
| advanced non-cardia gastric cancer and helicobacter pylori infection in vietnam. | the incidence of gastric cancer in the northern city, hanoi is higher than in the southern city, ho chi minh, vietnam. we previously reported that helicobacter pylori vaca m1 genotype might be responsible for the difference between the two cities, however, the study only included non-cancer patients. the aim of this study is to investigate the non-cardia gastric cancer characteristics and the role of h. pylori virulence on different non-cardia gastric cancer incidence between two cities in vietn ... | 2017 | 28824711 |
| oral immunization with a multivalent epitope-based vaccine, based on nap, urease, hsp60, and hpaa, provides therapeutic effect on h. pylori infection in mongolian gerbils. | epitope-based vaccine is a promising strategy for therapeutic vaccination against helicobacter pylori (h. pylori) infection. a multivalent subunit vaccine containing various antigens from h. pylori is superior to a univalent subunit vaccine. however, whether a multivalent epitope-based vaccine is superior to a univalent epitope-based vaccine in therapeutic vaccination against h. pylori, remains unclear. in this study, a multivalent epitope-based vaccine named cwae against h. pylori urease, neutr ... | 2017 | 28824883 |
| crosstalk between dna damage and inflammation in the multiple steps of carcinogenesis. | inflammation can be induced by chronic infection, inflammatory diseases and physicochemical factors. chronic inflammation is estimated to contribute to approximately 25% of human cancers. under inflammatory conditions, inflammatory and epithelial cells release reactive oxygen (ros) and nitrogen species (rns), which are capable of causing dna damage, including the formation of 8-oxo-7,8-dihydro-2'-deoxyguanosine and 8-nitroguanine. we reported that 8-nitroguanine was clearly formed at the sites o ... | 2017 | 28825631 |
| the role of the c-terminal d0 domain of flagellin in activation of toll like receptor 5. | flagellin is a wide-spread bacterial virulence factor sensed by the membrane-bound toll-like receptor 5 (tlr5) and by the intracellular naip5/nlrc4 inflammasome receptor. tlr5 recognizes a conserved region within the d1 domain of flagellin, crucial for the interaction between subunits in the flagellum and for bacterial motility. while it is known that a deletion of the d0 domain of flagellin, which lines the interior of flagella, also completely abrogates activation of tlr5, its functional role ... | 2017 | 28827825 |
| a comprehensive review on pharmacotherapeutics of three phytochemicals, curcumin, quercetin, and allicin, in the treatment of gastric cancer. | gastric cancer is one of the most common causes of cancer-related death worldwide. medicinal plants are one of the main sources for discovery of new pharmacological agents especially for treatment of cancers. the aim of the present study is to review pharmacotherapeutic aspects of three mostly studied phytochemicals including curcumin, quercetin, and allicin for management of gastric cancer. | 2017 | 28828709 |
| reduced mir-490-3p expression is associated with poor prognosis of helicobacter pylori induced gastric cancer. | helicobacter pylori (hp) infection has been demonstrated to be a risk factor accounting for the initiation and development of gastric cancer (gc). the aim of the present study was to investigate the clinical significance of mir-490-3p in hp associated gc. | 2017 | 28829504 |
| [the efficacy of moxifloxacin-containing triple therapy after hybrid therapy failure in helicobacter pylori eradication]. | hybrid therapy was successful in eradicating helicobacter pylori (h. pylori) according to previous reports. however, to the best of our knowledge, there have only been a few studies evaluating the optimal choice after hybrid failure. hence, we aimed to evaluate the efficacy of moxifloxacin-containing triple therapy after hybrid therapy failure in h. pylori eradication. | 2017 | 28830132 |
| characteristics and risk factors for sporadic non-ampullary duodenal adenocarcinoma. | despite the gradual increase in the incidence of non-ampullary duodenal adenocarcinoma (nadac), the associated characteristics and risk factors remain poorly understood. the aim of this study was to clarify the clinical characteristics and risk factors of sporadic nadac. | 2017 | 28830268 |
| shotgun metagenomic data on the human stool samples to characterize shifts of the gut microbial profile after the helicobacter pylori eradication therapy. | the shotgun sequencing data presented in this report are related to the research article named "gut microbiome shotgun sequencing in assessment of microbial community changes associated with h. pylori eradication therapy" (khusnutdinova et al., 2016) [1]. typically, the h. pylori eradication protocol includes a prolonged two-week use of the broad-spectrum antibiotics. the presented data on the whole-genome sequencing of the total dna from stool samples of patients before the start of the eradica ... | 2017 | 28831408 |
| efficacy of three-in-one capsule bismuth quadruple therapy for helicobacter pylori eradication in clinical practice in a multinational patient population. | bismuth quadruple therapy (bqt) has been proven superior to standard triple therapy for helicobacter pylori eradication in randomized clinical trials; however, little is known about the efficacy of bqt in daily routine practice. | 2017 | 28833925 |
| endoscopic characteristics of infection-associated peptic ulcers. | aside from helicobacter pylori, another cause for the development or worsening of gastrointestinal ulcers is scrub typhus, an acute febrile disease caused by orientia tsutsugamushi. we aimed to compare the endoscopic characteristics of peptic ulcers caused by these infectious agents. | 2017 | 28833968 |
| protective efficacy of a hydroxy fatty acid against gastric helicobacter infections. | we have previously revealed that omega-3 polyunsaturated fatty acids can prevent helicobacter pylori infection by blocking the futalosine pathway, an alternative route for menaquinone (mk) biosynthesis. | 2017 | 28834011 |
| "transition state analogue inhibitors of 5'-deoxyadenosine/5'-methylthioadenosine nucleosidase from mycobacterium tuberculosis". | mycobacterium tuberculosis 5'-deoxyadenosine/5'-methylthioadenosine nucleosidase (rv0091) catalyzes the n-riboside hydrolysis of its substrates 5'-methylthioadenosine (mta) and 5-deoxyadenosine (5'-dado). 5'-dado is the preferred substrate, a product of radical sam-dependent enzyme reactions. rv0091 is characterized by a ribocation-like transition state, with low n-ribosidic bond order, an n7 protonated adenine leaving group and an activated but weakly bonded water nucleophile. dadme-immucillin ... | 2017 | 28836767 |
| pbx1 attributes as a determinant of connexin 32 downregulation in helicobacter pylori-related gastric carcinogenesis. | to clarify the mechanisms of connexin 32 (cx32) downregulation by potential transcriptional factors (tfs) in helicobacter pylori (h. pylori)-associated gastric carcinogenesis. | 2017 | 28839434 |
| aggressive helicobacter pylori-negative peptic ulceration as the initial manifestation of crohn's disease. | peptic ulceration is a recognised feature of crohn's disease, but the characteristics of this manifestation are rather poorly described. furthermore, most reports in the literature relate to ulcer disease in cases of established crohn's disease. the authors report a series of four cases in which the diagnosis of crohn's disease was preceded by peptic ulceration. potential confounding factors were as far as possible excluded, implying a true association. characteristics of the ulcer disease inclu ... | 2012 | 28839665 |
| upper gastrointestinal haemorrhage: an update. | upper gastrointestinal (gi) haemorrhage is a common cause for admission to hospital and is associated with a mortality of around 10%. prompt assessment and resuscitation are vital, as are risk stratification of the severity of bleeding, early involvement of the multidisciplinary team and timely access to endoscopy, preferably within 24 h. the majority of bleeds are due to peptic ulcers for which helicobacter pylori and non-steroidal anti-inflammatory agents are the main risk factors. although pr ... | 2016 | 28839832 |
| specific mutations of penicillin-binding protein 1a in 77 clinically acquired amoxicillin-resistant helicobacter pylori strains in comparison with 77 amoxicillin-susceptible strains. | amoxicillin (amx) is one of the most important antibiotics for eradication of helicobacter pylori (h. pylori). main determinants of genetically stable amx resistance are mutations in the c-terminus of penicillin-binding protein 1a (pbp1a). however, contribution of individual mutation remains unclear. | 2017 | 28840971 |
| evaluation and management of gastric epithelial polyps. | gastric polyps include a wide spectrum of lesions with different histology and neoplastic potential. they are found in up to 6% of upper gastrointestinal endoscopy and are usually asymptomatic and incidentally diagnosed, being in the vast majority epithelial gastric polyps. hyperplastic, fundic gland and adenomas are the most common types of gastric polyps and, although each type may have typical endoscopic appearances, they all must be sampled at the initial endoscopy for histological assessmen ... | 2017 | 28842047 |
| the arms race between man and mycobacterium tuberculosis: time to regroup. | an arms race is an appropriate metaphor to use for the interaction of man and mycobacterium tuberculosis (m.tb) through the millennia. estimates of the time of infection of modern humans with m.tb often pre-date the out-of-africa migration. humans have adapted to the changing environment during the migration with respect to climate, food sources and encounters with local pathogens. more recently, there has been adaptation to the demographic changes brought about in the majority of the human popu ... | 2017 | 28843547 |
| helicobacter pylori outer membrane protein q genotypes and their susceptibility to anti-adhesive phytotherapeutic agents. | helicobacter pylori is a gram-negative organism. its outer membrane protein q (hopq) mediates host-pathogen interactions; hopq genotypes 1 and 2 are found associating with gastroduodenal pathologies. the authors measured the anti-adhesion effects of the extracts of abelmoschus esculentus, zingiber officinale, trachyspermum ammi, glycyrrhiza glabra, curcuma longa and capsicum annum against hopq genotypes and h. pylori cytotoxin-associated gene a (caga). | 2017 | 28844217 |
| tlr2 arg677trp but not tlr2 -196 to -174 ins/del and arg753gln polymorphism alter the risk of peptic ulcer in north of iran. | most polymorphisms that occur in tlr-2 are associated with gastrointestinal disorders such as peptic ulcer disease (pud). hence, in current study, association between tlr2-196 to -174 ins/del, arg753gln and arg677trp polymorphisms and risk of pud development in north of iran was evaluated. | 2017 | 28844484 |
| successful eradication of helicobacter pylori with a herbal medicine, goshuyuto (wu zhu yu tang), plus rabeprazole after failure of triplet therapy with vonoprazan: a report of three cases. | vonoprazan, a potassium-competitive acid blocker, is used as a substitute drug for conventional proton pump inhibitors. recently, vonoprazan has been applied for eradication of h. pylori (hp) infection, and the efficacies of vonoprazan-based triple therapy against hp infection have already been reported. however, treatment sometimes fails in the primary and/or secondary triplet eradication therapy, including with the use of vonoprazan for hp infection. we experienced three cases of refractory hp ... | 2017 | 28845910 |
| the usefulness of investigating the possible underlying conditions in rosacea. | the paper entitled "rosacea and demodicidosis with gain of function mutation in stat1″ by second et al.(1) is of indubitable interest and prompted us to make some observations. the authors described a patient with cutaneous and ocular rosacea that they related to demodicidosis since oral ivermectin improved the cutaneous lesions(1) . however, the authors did not demonstrate by skin scraping nor by standardized skin surface biopsy (sssb) an excessive number of demodex folliculorum (df) mites in t ... | 2017 | 28846817 |
| rosacea and helicobacter pylori: links and risks. | rosacea is a chronic skin disease characterized by facial erythema and telangiectasia. despite the fact that many hypotheses have been proposed, its etiology remains unknown. in the present review, the possible link and clinical significance of helicobacter pylori in the pathogenesis of rosacea are being sought. a pubmed and google scholar search was performed using the terms "rosacea", "h.pylori", "gastrointestinal disorders and h.pylori", "microorganisms and rosacea", "pathogenesis and treatme ... | 2017 | 28848358 |