Publications
| Title | Abstract | Year Filter | PMID(sorted ascending) Filter |
|---|
| effect of vaccinia virus on malignant melanoma of hamsters. | 1966 | 5943360 | |
| induction of cytoplasmic ribonucleic acid (rna) synthesis in vaccinia-infected lm cells during inhibition of protein synthesis. | 1966 | 5949673 | |
| the vmk variant of a strain of poxvirus officinale. 3. further differentiation of the vmk strain. | 1966 | 5950218 | |
| immunoelectrophoretic analysis of vaccinia virus. | 1966 | 5950825 | |
| autointerference of rabies virus in chick embryo fibroblasts. | 1966 | 5951071 | |
| studies on placentae and infants from women vaccinated for smallpox during pregnancy. | sixty-five placentae from women who had been vaccinated while pregnant were examined for the presence of the inclusion bodies of vaccinia. also suspensions from 40 of the placentae were inoculated into the chorio-allantoic membrane of chick embryos in an attempt to culture any vaccinia virus present. both these studies gave negative results.the results of the pregnancies of these 65 women showed no increase in the incidence of abortion, stillbirth, or congenital abnormalities, over the unvaccina ... | 1966 | 5951719 |
| quantitative studies on fabrics as disseminators of viruses. i. persistence of vaccinia virus on cotton and wool fabrics. | the persistence of vaccinia virus on wool (blanket and gabardine) and cotton (sheeting, terry cloth, and knit jersey) fabrics was studied. the fabrics were exposed to the virus by three methods: direct contact, aerosol, and virus-containing dust having a high content of textile fibers. fabrics exposed to virus by each method were held in 35 and 78% relative humidities at 25 c. virus was recovered for up to 14 weeks from wool fabrics exposed to virus and held in the low humidity. in contrast, vir ... | 1966 | 5953019 |
| role of plasma factors in the transformation of peripheral blood lymphocytes into lymphoblasts. | 1966 | 5954573 | |
| inhibiting effect of increasing body-weight on the lethal response of dba-i mice to vaccinia virus infection. | 1966 | 5954584 | |
| vaccinia virus hi-antibody blocked by a non-haemagglutinating extract of vaccinia infected cam. | 1966 | 5954974 | |
| on the neoplastic transformation induced by vaccinia virus in primary cultures of mouse embryos. | 1966 | 5961914 | |
| the reaction of vaccinia virus with deoxycholate. | 1966 | 5965994 | |
| method for enchancement of electron microscopic visualization of embedded antigen by bridging osmium to uranium antibody with thiocarbohydrazide. | 1966 | 5969756 | |
| cultivation and immunological studies of the pox group of viruses. i. propagation of vaccinia virus in hamster kidney cell culture. | 1966 | 5969955 | |
| synthesis of dna and protein in cells infected with vaccinia virus. | 1966 | 5971691 | |
| [pyodermia chancriformis]. | 1966 | 5976210 | |
| simultaneous infection with foot and mouth disease and vaccinia virus. | 1966 | 5977007 | |
| effect of concomitant treatment by cortisone and n-ethylisatin beta-thiosemicarbazone on neurovaccinia virus infected mice. | 1966 | 5980557 | |
| the wet preservation of vaccinia virus. | 1966 | 5982354 | |
| [a simple and rapid method for differentiation between vaccine (poxvirus officinale) and cow pox virus (poxvirus bovis)]. | 1966 | 5984723 | |
| effect of n-ethylisatin beta-thiosemicarbazone and anticonvulsant drugs on tonic convulsions in neurovaccinia-infected mice. | 1966 | 5985283 | |
| evaluation of antiviral compounds by suppression of tail lesions in vaccinia-infected mice. | 1966 | 5985284 | |
| [investigation on the formation of serum antibodies after revaccination with vaccinia virus]. | 1966 | 5990063 | |
| [the determination of the density of viruses in a cesium chloride-water gradient. comparative studies of vaccinia virus and ectromelia virus]. | 1966 | 5991313 | |
| [a modified method of inoculation of chorioallantoic membranes for virus cultivation]. | 1966 | 5992407 | |
| [effect of some inhibitors on the formation of the factor of nucleocapside deproteinization in vaccinia virus]. | 1966 | 5994933 | |
| [on the demonstration of airborne viruses. experiments on the sedimentation of viruses in aerosols]. | 1966 | 5995378 | |
| a simplified plaque technique for titration of pox virus and its antibodies in chick embryo cells. | 1966 | 6006243 | |
| experiences with improvement of the neutralization reaction with vaccinia virus in chick fibroblast cultures. | 1966 | 6006816 | |
| [effects of histone on the intracellular development of vaccinia virus]. | 1966 | 6008708 | |
| [clinical and experimental studies on the passive transferability of vaccinal tissue allergie. "cellular transfer" of delayed type hypersensitivity]. | 1966 | 6011443 | |
| [virus inhibition in vitro by 6-azalumazine]. | 1966 | 6014906 | |
| methisazone in progressive vaccinia. | 1967 | 6018450 | |
| effect of interferon on early enzyme and viral dna synthesis in vaccinia virus infections. | 1967 | 6025067 | |
| vaccinial vulvo-vaginitis. | 1967 | 6027655 | |
| [relations between rectal temperature and skin temperature in animals and the dermo-virulence of some "cold" and "warm" mutants of vaccinia virus]. | 1967 | 6031419 | |
| [absence of a relation between sensitivity to interferon, interferon production and virulence of "cold" and "warm" mutants of vaccinia virus]. | 1967 | 6048200 | |
| hybridization and sedimentation studies on "early" and "late" vaccinia messenger rna. | 1967 | 6049681 | |
| loss of interferon activity from the medium of cell cultures producing interferon. | 1967 | 6050682 | |
| studies on the mechanism of action of interferon: inhibition of thymidine kinase induction in vaccinia virus-infected chick embryo cells. | 1967 | 6053307 | |
| structure and antiviral activity of substituted potassium benzylaminothiomethane-sulphonates and allied compounds. | 1967 | 6055246 | |
| mode of antiviral action of potassium benzylaminothiomethane sulphonate and some derivatives. | 1967 | 6055255 | |
| some potential antiviral agents. | 1967 | 6055256 | |
| a simple method for reduction of non-specific fluorescence. | 1967 | 6055951 | |
| water as a factor in the photoinactivation of vaccinia virus. | 1967 | 6060236 | |
| antiviral action of oxidized spermine: inactivation of certain animal viruses. | 1967 | 6060573 | |
| influence of the physical state of formalinized vaccinia virus particles on surviving plaque titer: evidence for multiplicity reactivation. | 1967 | 6060970 | |
| studies on vaccinia virus dna. | 1967 | 6062174 | |
| the effect of deoxyribonuclease on the synthesis of dna of vaccinia virus. | 1967 | 6062181 | |
| vaccinia epidemic and epizootic in el salvador. | 1967 | 6067215 | |
| relation of the pfu value to the volume of inoculum in the titration of vaccinia virus on the chorioallantoic membrane of the chick embryo. | 1967 | 6070332 | |
| transference of maternal passive immunity to vaccinia virus in mice. | 1967 | 6075255 | |
| [thermomimetic effect of urea on the development of vaccinia virus]. | 1967 | 6076177 | |
| [influence of supraoptimal temperatures on the development of vaccinia virus in cell cultures. 3. cytologic study of the synthesis of viral antigens]. | 1967 | 6077390 | |
| influence of tissue differentiation on susceptibility to virus infection. | 1967 | 6081699 | |
| studies on the standardization of smallpox vaccine. 3. an assay with a rabbit preliminarily immunized by passive immunization. | 1967 | 6081786 | |
| the virus of molluscum contagiosum and its adsorption to mouse embryo cells in culture. | 1967 | 6082334 | |
| respiratory infection of mice with vaccinia virus. | 1967 | 6082340 | |
| cell cultures of spotted souslik--preliminary characterization of their growth and sensitivity to viruses. | cell cultures from the cutaneo-muscular tissue of fetuses (se), and from lungs (sl), kidneys (sk), testes (ste) of adult spotted sousliks were obtained. cells from lungs (sl) were viable at 4 degrees c three times longer than fibroblastic cells of human embryos (hef). at 37 degrees c the growth rate of sl, hef and l929 cells was similar. however, at 26 degrees c sl cells grew faster than hef or l929 cells and their population doubling time was shorter. the cultures of se, sl and sk cells were se ... | 1984 | 6085465 |
| 5' end labeling of rna with capping and methylating enzymes. | 1981 | 6086038 | |
| organization of rna transcripts from a vaccinia virus early gene cluster. | the detailed organization of the rnas transcribed from an early gene cluster encoded by vaccinia virus has been determined from the information derived from several complementary techniques. these include hybrid selection coupled with cell-free translation to locate dna sequences complementary to mrnas encoding specific polypeptides; rna filter hybridization to size and locate on the dna mature rnas as well as higher-molecular-weight rnas; s1 nuclease mapping to precisely locate the 5' and 3' en ... | 1984 | 6086946 |
| [biological activity of transition metal complexes. 5. effect of dimethyl sulfoxide on the cytotoxic, antiviral and antitumoral properties of cis-dichlorodiammineplatinum (ii): "cisplatin"]. | in water or dimethyl sulfoxide solutions cis-platinum is subject of time depending solvolytic reactions leading to compounds with different biological effectivity. whereas the inactivation of vaccinia, vesicular stomatitis and adeno virus type 5 was not changed if dimethyl sulfoxide or dimethyl formamide instead of destilled water were used as solvents, long time stored solutions of cis-platinum in dimethyl sulfoxide were tolerated by cells cultivated in vitro in 8-25 times higher concentrations ... | 1984 | 6087577 |
| regulation of expression and nucleotide sequence of a late vaccinia virus gene. | a subset of vaccinia virus genes are expressed only after dna replication. to investigate the regulation of such transcriptional units, a representative gene encoding a major late polypeptide (mr, 28,000) was mapped and sequenced. translatable mrnas were heterogeneous in length and overlapped several early genes downstream. the 5' end of the message was located, and the dna segment upstream was excised and ligated to the coding sequence of the easily assayable procaryotic chloramphenicol acetylt ... | 1984 | 6088791 |
| [neutralizing virus antibodies in human immunoglobulins for intravenous use]. | neutralizing antibodies against measles, poliomyelitis, rubella, herpes simplex, influenza and vaccinia viruses were measured in batches of a representative selection of human immunoglobulins for intravenous use licensed in the federal republic of germany. rubella antibodies were also examined by haemagglutination-inhibition tests. where available, reference preparations were used, and antibody levels expressed in i. u. all preparations contained significant amounts of the examined antibodies, w ... | 1984 | 6090309 |
| identification of the dna sequences encoding the large subunit of the mrna-capping enzyme of vaccinia virus. | the dna sequences encoding the large subunit of the mrna-capping enzyme of vaccinia virus were located on the viral genome. the formation of an enzyme-guanylate covalent intermediate labeled with [alpha-32p]gtp allowed the identification of the large subunit of the capping enzyme and was used to monitor the appearance of the enzyme during the infectious cycle. this assay confirmed that after vaccinia infection, a novel 84,000-molecular-weight polypeptide corresponding to the large subunit was ra ... | 1984 | 6090698 |
| serologic response to human melanoma lines from patients with melanoma undergoing treatment with vaccinia melanoma oncolysates. | specific active tumor immunotherapy methods offer the possibility of increasing the immunogenicity of tumor cells. one of these methods is viral oncolysis, in which tumor cells are modified by viral infection. we prepared vaccinia melanoma oncolysates (vmo) from human melanoma lines infected with vaccinia virus. in a preliminary trial at washington university, sera from 12 patients with melanoma with stage i and ii disease were obtained before and during treatment with vmo. the reactivity of the ... | 1984 | 6091287 |
| antiviral action of 5-amino-2-(2-dimethyl-aminoethyl)benzo-[de]-isoquinolin-1,3-dion e. | a newly synthesized imide derivative of 3-nitro-1,8-naphthalic acid, 5-amino-2-(2-dimethylaminoethyl)benzo-[de]-isoquinolin-1,3-dione (designated m-fa-142), was tested on chick embryo cells against herpes simplex virus type 1 (hsv-1) and vaccinia virus (vv), and on vero cells against african swine fever virus (asfv). at a concentration of 4 micrograms/ml the drug inhibited vv replication by about one order of magnitude, and that of hsv-1 by about three orders of magnitude. a minor effect was sho ... | 1984 | 6091540 |
| rna capping by the vaccinia virus guanylyltransferase. structure of enzyme-guanylate intermediate. | gtp:rna guanylyltransferase isolated from vaccinia virus catalyzes the transfer of gmp from gtp to the 5' terminus of rna via an enzyme-guanylate intermediate. incubation of the purified vaccinia rna guanylyltransferase with [alpha- 32p]gtp and mgcl2 yields [32p]gmp covalently linked to the mr = 95,000 subunit. the bond involves the phosphate moiety of gmp and the ne-amino group of lysine. this was verified by treatment of the isolated 95-kda subunit-[32p]gmp complex with sodium periodate, follo ... | 1984 | 6092377 |
| synthesis and antiviral/antitumor activities of certain 3-deazaguanine nucleosides and nucleotides. | a new procedure for the preparation of the antiviral and antitumor agent 3-deazaguanine (1) and its metabolite 3-deazaguanosine (2) has been developed by reacting methyl 5(4)-(cyanomethyl) imidazole-4(5)-carboxylate (4) and 5-(cyanomethyl)-1- (2,3,5-tri-o-benzoyl-beta-d-ribofuranosyl)imidazole-4-carboxylate (6), respectively, with hydrazine. the 3-deazaguanosine 3',5'-cyclic phosphate (13) was prepared from 5-(cyanomethyl)-1-beta-d-ribofuranosyl-imidazole-4-carboxamide 5'-phosphate. glycosylatio ... | 1984 | 6092634 |
| nucleic acid related compounds. 47. synthesis and biological activities of pyrimidine and purine "acyclic" nucleoside analogues. | various acyclic, i.e., (2-hydroxyethoxy)methyl and (2-acetoxyethoxy)methyl, analogues of pyrimidine and purine nucleosides have been prepared and evaluated for their antiviral, antimetabolic, and cytotoxic properties. all of the pyrimidine analogues, including (e)-5-(2-bromovinyl)-1-[(2-hydroxyethoxy)methyl]uracil (12) and its o-acetyl derivative (13), were virtually devoid of antiviral, cytotoxic, and antimetabolic activities. however, several of the 8-substituted derivatives of 9-[(2-hydroxyet ... | 1984 | 6092636 |
| nucleotide sequence of an immediate-early frog virus 3 gene. | we have used "gene walking" with synthetic oligonucleotides and m13 dideoxynucleotide sequencing techniques to obtain the complete coding and flanking sequences of the gene encoding a major immediate-early rna (molecular weight, 169,000) of frog virus 3. r-loop mapping of the cloned xbai k fragment of frog virus 3 dna with immediate-early rna from infected cells showed that an rna of approximately 500 to 600 nucleotides (the right size to code for the immediate-early viral 18-kilodalton protein ... | 1984 | 6092719 |
| arginine metabolism in infected cell cultures as a marker character for the differentiation of orthopoxviruses. | arginine has been shown to be essential for the replication of several orthopoxviruses in mouse sarcoma 180 cells and in chick embryo fibroblast cultures. both host systems are characterized by their inabilities to utilize citrulline for the biosynthesis of arginine due to deficiencies in the requisite cellular enzymes and cell multiplication is absolutely dependent on the availability of exogenous arginine. virus replication in such cells maintained with citrulline results from the induction of ... | 1984 | 6094662 |
| protection from rabies by a vaccinia virus recombinant containing the rabies virus glycoprotein gene. | inoculation of rabbits and mice with a vaccinia-rabies glycoprotein recombinant (v-rg) virus resulted in rapid induction of high concentrations of rabies virus-neutralizing antibodies and protection from severe intracerebral challenge with several strains of rabies virus. protection from virus challenge also was achieved against the rabies-related duvenhage virus but not against the mokola virus. effective immunization by v-rg depended on the expression of a rabies glycoprotein that registered p ... | 1984 | 6095272 |
| potentiation of interferon's antiviral activity by the mutually synergistic interaction of muifn-alpha/beta and muifn-gamma. | the interaction of the interferons (ifns) that cooperate to potentiate the antiviral action of ifn was studied. serial dilutions of muifn-gamma and muifn-alpha/beta were employed separately and in combination to block virus replication in one-step, virus yield reduction experiments. to calculate the potentiation of ifn activity, protection levels obtained for each combination of muifn-gamma and muifn-alpha/beta were compared with those obtained for the separate ifns. potentiation levels increase ... | 1984 | 6096507 |
| effects of microwave exposure on the hamster immune system. iii. macrophage resistance to vesicular stomatitis virus infection. | exposure of hamsters to microwave (mw) energy (2.45 ghz, 25 mw/cm2, 1 h) resulted in activation of peritoneal macrophages (pm) to a viricidal state restricting the replication of vesicular stomatitis virus (vsv). the pm from mw-exposed hamsters were viricidal as early as 1 day after exposure and remained active for 5 days. immunization of hamsters with vaccinia virus induced viricidal pm by 3 to 4 days and they remained active for 7 days. to test the hypothesis that thermogenic mw exposure resul ... | 1984 | 6097258 |
| genetically engineered poxviruses: a novel approach to the construction of live vaccines. | gene splicing techniques have been used to modify the smallpox vaccine virus thus providing a generic approach for the construction of live vaccines directed against a variety of heterologous infectious disease agents. the technique involves translocating a particular gene from an infectious agent into the genetic material of the smallpox vaccine virus. this unique foreign gene, selected because it contains the information essential for the synthesis of an antigen important in immunity to that p ... | 1984 | 6099648 |
| novel codon utilization within the vaccinia virus thymidine kinase gene. | the nucleotide and predicted amino acid sequences of the thymidine kinase genes encoded by vaccinia virus and herpes simplex virus (type 1) were analyzed, and there was no evidence of any significant homology. the manner in which the triplet code was used by each virus was also examined. the frequencies of codon utilization by the herpes virus gene were very similar to those used by most human genes, whereas the vaccinia virus gene was quite distinct, suggesting novel evolutionary and regulatory ... | 1984 | 6099662 |
| recombinant vaccinia viruses as new live vaccines. | 1984 | 6100668 | |
| use of vaccinia virus as an infectious molecular cloning and expression vector. | 1983 | 6101027 | |
| lack of correlation between complications after smallpox vaccination and the abo blood-group system. | blood group [abo system] distribution was analysed in 245 children with complications after smallpox vaccination. one hundred and thirty-two children had neurological and 113 and skin or mucosal complications. 41.6% of the children were blood-group a or ab. 58.4% were blood group o or b, which was not a significant difference from the normal population [44.7%---48.7% and 51.0%---55.9%, respectively]. the analysis did not show in persons possessing blood groups a or ab an enhanced susceptibility ... | 1980 | 6106028 |
| uptake of viruses by kupffer cells isolated from human liver. | 1980 | 6106759 | |
| study of genome homology of some orthopoxviruses. | homology between dnas of some orthopoxviruses: vaccinia, neurovaccinia, cowpox, ectromelia, variola and white-pox was studied. by the method of molecular hybridization of labelled virion dnas of the viruses studied with an excess of unlabelled vaccinia dna and further treatment of the hybridized products by the single-stranded-specific nuclease s1, it was shown that the concentration of unlabelled vaccinia virus dna, converting 50% of homologous labelled dna into a hybrid, converted under simila ... | 1980 | 6107030 |
| raised cytomegalovirus-antibody level in cerebrospinal fluid of schizophrenic patients. | the serum and cerebrospinal fluid (csf) of 60 schizophrenic patients and 26 controls were analysed for viral antibody against cytomegalovirus (cmv), vaccinia virus, herpes simplex virus type 1 (hsv), and type a influenza virus. a csf/serum antibody ratio more than 2 standard deviations above the mean of the controls suggested local antibody production in the central nervous system. 68% of the patients had an increased csf/serum antibody ratio for cmv antibody, 14% for vaccinia antibody, 4% for h ... | 1980 | 6107453 |
| the search for antiviral agents among corynebacteria. | extracts of strains of corynebacterium diphtheriae var. mitis avirulent, c. hofmannii, c. xerosis, c. parvum and an unidentified corynebacterium species were tested for antiviral activity against laboratory strains of echovirus type 11, adenovirus type 2 and vaccinia, and a recent isolate of herpes simplex virus. unlike a previous study, no appreciable antiviral activity was detected in the extracts tested | 1980 | 6108068 |
| characteristics of the antiviral effect of 9-(s)-(2, 3-dihydroxypropyl)adenine. | 9(s)-(2,3-dihydroxypropyl)adenine (dhpa) at 1--3 mg/ml completely inhibited the replication of vaccinia virus in zp cells; the analogue did not inactivate the virus. formation of a virus component sensitive to dhpa preceded by 2 hr the formation of infectious vaccinia virus. it seems likely that the component inhibited by dhpa is viral mrna. the virus inhibitory effect was not reverted by numerous nucleotides, nucleosides or amino acids. dhpa was not metabolized during the latent period of vacci ... | 1980 | 6111203 |
| effect of n, n'-bis(methylisatin-beta-thiosemicarbazone)-2-methylpiperazine against virus-induced encephalitis in mice). | n,n'-bis(methylisatin-beta-thiosemicarbazone)-2-methylpiperazine (tski-vi) proved to be significantly effective against lethal vaccinia, pseudorabies and mengo virus-induced encephalitis in different strains of mice when administered subcutaneously (s.c.) in doses of 20 mg/kg body weight, twice daily, for a period of five days. the strongest effects occurred in vaccinia virus-infected mice, and the degree of protection was both dose- and virus-dependent. titres of vaccinia virus in brains of inf ... | 1980 | 6111204 |
| rna sequences of opposite polarities transcribed from a large part of vaccinia virus genome are accumulated in the cytoplasm. | labelled vaccinia virus dna was used in saturation-hybridization experiments with rna extracted from virus-infected cells. an excess of "late" cytoplasmic rna converted 45% of dna into dna-rna hybrids, whereas 17% of dna could be converted into hybrids by rna extracted from purified nuclei. rna-rna hybrids obtained from cytoplasmic rna by self-annealing and ribonuclease treatment, were melted and used in hybridization with dna: 36% of dna was hybridized at the maximal concentration used. | 1980 | 6111206 |
| [the pathogenesis of postvaccinal complications]. | paraspecific reactions to vaccines are -- induction of autoimmune mechanisms, -- immunosuppression, -- induction of inflammation (i.e. "reactogenicity"). these undesirable side effects of vaccination are important factors in pathogenesis of postvaccinal complications. using the model of experimental vaccinia virus infection the paraspecific reactions could be demonstrated in several animal species. cell mediated hypersensitivity to brain tissue antigen and basic encephalitogenic protein occurred ... | 1981 | 6112195 |
| replication of poxvirus dna in chick embryo fibroblasts. | replication of vaccinia virus dna in chick embryo fibroblasts at a high multiplicity of infection started after 4-6 hr, reached a maximum at the 12th hr and was completed 18 hr after inoculation (p.i.). an analysis of newly synthesised dnas in the period of the highest rate of synthesis revealed the formation of short (10-30s) fragments which within 30 min were transformed into single-stranded molecules with a sedimentation coefficient of 62s. the final stage of closing of the ends of single-str ... | 1981 | 6112860 |
| the effect of dipyridamole on the multiplication of vaccinia virus in rk13 cells. | 1981 | 6116424 | |
| comparative analysis of the degree of specific humoral immunity, content of serum immunoglobulins and isolation of vaccinia virus in children with post-vaccinal encephalitis after smallpox vaccination. | considerable variations were found in the content of virus neutralizing antibodies (vna) to smallpox in 35 children with postvaccinal encephalitis (pve) which developed after vaccination against smallpox: the titre of vna was high in 7 children, negligible in 14, and in 6 children vna were not present 3-4 weeks after vaccination. dependence of the production of vna on the peculiarities of individual development and premorbid state of the patients as well as on serotherapy was analysed; the role ... | 1981 | 6117594 |
| [results of a study of the pathogenesis of postvaccinal encephalitis]. | the results of 10-year virological and immunological studies in patients with postvaccination encephalitis (pve) developing after smallpox vaccination are analysed. vaccinia virus was isolated from 23 (59%) out of 39 children in the acute stage of pve and for a long period in the protracted course of the disease in 14 out of 24 from the cerebrospinal fluid in 15 out of 33 from the blood, in 8 out of 24 from the throat and in 4 out of 5 from the brain or spinal cord tissue. examinations of 56 ser ... | 1981 | 6117985 |
| antiviral activity of substituted 6-methylmercaptopyrazolo(3,4-d)pyrimidines and their ribosides. | the antiviral activities of pyrazolo(3,4-d)pyrimidines and their nucleosides, divided into 7 groups based on the substituent in position 4 (mercapto-, methylmercapto-, amino-, hydrazine-, dialkyl amino-, oxy-, and methoxyderivatives), were studied against herpes simplex virus type 1 (hsv 1) and vaccinia virus. numerous compounds inhibited the virus yields by 1-4 log cpd50. most antiviral compounds inhibited hsv 1 more than vaccinia virus. only methylmercapto- derivatives inhibited both viruses a ... | 1981 | 6118054 |
| evaluation of hamster natural cytotoxic cells and vaccinia-induced cytotoxic cells for thy-1.2 homologue by using a mouse monoclonal alpha-thy-1.2 antibody. | 1982 | 6126504 | |
| antiviral activity of hetarylhydrazones. | some hetarylhydrazones showed antiviral activity against mengo virus in vitro. the replication of influenza a and b viruses was affected neither in vitro (chick chorioallantoic membranes) nor in vivo (mice). based on dose response curves of the active hetarylhydrazones the compound z 98/69 appeared most effective in vitro. this compound neither inactivated the extracellular virus nor inhibited its adsorption and penetration; it reduced virus replication when added 1-3 hr after mengo virus inocul ... | 1982 | 6127013 |
| animal virus screens for potential teratogens. i. poxvirus morphogenesis. | the growth of poxvirions in cell culture is considered a teratogen screening test, since this virus has a rapid, simple morphogenetic pathway that is dependent upon cell proliferation. vaccinia wr-infected bsc 40 monolayers were exposed to 42 known teratogens and 9 nonteratogens at dosages from 1 microm to 100 mm. after 24 h of infection, the number of functional virions was determined by plaque assay. thirty-three of the 42 teratogens inhibited the virus, 3 teratogens stimulated the virus, and ... | 1982 | 6130636 |
| phenotypic mixing of vesicular stomatitis virus (vsv) with vaccinia virus. | 1982 | 6132548 | |
| [immunofluorescent method of detecting viremia in postvaccinal complications]. | 1983 | 6135280 | |
| transport of antiviral agent 9-(s)-(2,3-dihydroxypropyl) adenine to animal cells. | transport properties of 9-(s)-(2,3-dihydroxypropyl) adenine (dhpa) in cell cultures were studied. transport of dhpa into chick embryo (ce), zp (a cell line derived from rabbit lungs) and hela cells reached equilibrium values after 10 min incubation. the concentration of intracellular dhpa varied from 30 to 50 per cent of that in the medium. dhpa transport was only slightly affected during the lag phase of vaccinia virus replication. the opinion that dhpa is transported into the cell by facilitat ... | 1983 | 6135330 |
| vaccinia virus in postvaccinal encephalitis. | results of virological examination of 239 samples taken from 84 children with neurological complications after smallpox vaccination are described. in postvaccinal encephalitis, vaccinia virus was isolated from blood, cerebrospinal fluid and pharyngeal secretions of 23 out of 40 children (57.5%) as well as from autopsy specimens sampled between 10-35 days after vaccination. during the acute period of disease, virus was detected in 17 out of 31 (54.2%) cerebrospinal fluid specimens. in 3 postvacci ... | 1983 | 6135334 |