Publications
| Title | Abstract | Year Filter | PMID(sorted ascending) Filter |
|---|
| enhancement of non-specific immune response in sea cucumber (apostichopus japonicus) by astragalus membranaceus and its polysaccharides. | in this study, the immunostimulatory effect of oral administration of different preparations (conventional fine powder [cp] and superfine powder [sp]) of astragalus membranaceus root or its polysaccharides (aps) in sea cucumber (apostichopus japonicus) was investigated. sea cucumbers with an average initial weight of 49.3 +/- 5.65 g were fed with a diet containing 3% cp or sp or 0.3% aps over a period of 60 days. the non-specific humoral (phenoloxidase, lysozyme and agglutination titer) and cell ... | 2009 | 19748588 |
| compound astragalus and salvia miltiorrhiza extract inhibits cell invasion by modulating transforming growth factor-beta/smad in hepg2 cell. | compound astragalus and salvia miltiorrhiza extract (case) is made up of astragalosides, astragalus polysaccharide and salvianolic acids extracted from astragalus membranaceus bunge (leguminosae) and salvia miltiorhiza bunge (lamiaceae) with a standard ratio. previous reports showed that case inhibited hepatic fibrosis by mediating transforming growth factor (tgf)-beta/smad signaling. this study further investigated the effect of case on hepatoma hepg2 cells stimulated by tgf-beta(1) and its pot ... | 2010 | 19793165 |
| astragalus polysaccharide improves insulin sensitivity in kkay mice: regulation of pkb/glut4 signaling in skeletal muscle. | astragalus polysaccharide (aps) is an important bioactive component of astragalus membranaceus bunge (leguminosae) that has been used in traditional chinese medicine for treating diabetes. | 2010 | 19800959 |
| the two isomers of hdtic compounds from astragali radix slow down telomere shortening rate via attenuating oxidative stress and increasing dna repair ability in human fetal lung diploid fibroblast cells. | 4-hydroxy-5-hydroxymethyl-[1,3]dioxolan-2,6'-spirane-5',6',7',8'-tetrahydro-indolizine-3'-carbaldehyde (hdtic)-1 and hdtic-2 are two isomers extracted from astragalus membranaceus (fisch) bunge var. mongholicus (bge) hsiao. our previous study had demonstrated that they could extend the lifespan of human fetal lung diploid fibroblasts (2bs). to investigate the mechanisms of the hdtic-induced delay of replicative senescence, in this study, we assessed the effects of these two compounds on telomere ... | 2010 | 19839736 |
| discrimination of polysaccharides from traditional chinese medicines using saccharide mapping--enzymatic digestion followed by chromatographic analysis. | polysaccharides isolated from traditional chinese medicines (tcms) exhibit multiple pharmacological activities. however, quality control of polysaccharides is a challenge because of their complicate structure and macro-molecular mass. in this study, saccharide mapping based on specific enzymatic digestion of polysaccharides and chromatographic analysis was proposed to discriminate the polysaccharides from different tcms. endo-carbohydrase such as glucanase, arabinanase, xylanase, galactanase, ce ... | 2010 | 19850432 |
| the effects of astragalus membranaceus on repeated restraint stress-induced biochemical and behavioral responses. | astragalus membranaceus (am) is a useful korean herb that has been clinically prescribed for stress-related illness. the objective of the present study was to examine the anti-stress effects of am on repeated stress-induced alterations of anxiety, learning and memory in rats. restraint stress was administered for 14 days (2h/day) and am (400mg/kg) given by oral administration, in the am group, for the same period. starting on the eighth day, the rats were tested for spatial memory on the morris ... | 2009 | 19885016 |
| evaluation of the adjuvant properties of astragalus membranaceus and scutellaria baicalensis georgi in the immune protection induced by uv-attenuated toxoplasma gondii in mouse models. | human vaccines are not available and current anti-toxoplasma treatment is disappointing. to investigate the possible adjuvant effect of aqueous extracts obtained from medicinal herbs of astragalus membranaceus (am) and scutellaria baicalensis georgi (sb) on the immune response to toxoplasma gondii in the mouse models induced by ultraviolet (uv)-attenuated t. gondii, this paper studies the possible vaccination strategies to help combat infections with toxoplasma and looking towards developing new ... | 2010 | 19887128 |
| effects of astragalus polysaccharide on the erythroid lineage and microarray analysis in k562 cells. | astragalus polysaccharide (aps), obtained from astragalus membranaceus, displays a range of activities in many systems, including the promotion of immune responses, anti-inflammation, and the protection of vessels. it possesses potent pharmacological activity on differentiation to the erythroid lineage. | 2010 | 19922785 |
| [analysis and identification of huangqi and its counterfeit ciguogancao by two dimensional corrlation infrared spectroscopy]. | standard huangqi (astragalus membranaceus (fisch) bge. var. monghlicus (bge.) hsiao) and its counterfeit ciguogancao (glychrrhiza pallidiflora maxim.) can be discriminated and identified by using multi-steps infrared maro--fingerprint method. in the 1d-ir spectra, the peak intensity at 1 737 cm(-1) for ciguogancao, which is the stretching vibration peak of c==o, is much stronger than that of huangqi. it's proved that the organic ester compounds in ciguogancao are much more than huangqi. in the s ... | 2009 | 19950637 |
| effect of a novel botanical agent drynol cibotin on human osteoblast cells and implications for osteoporosis: promotion of cell growth, calcium uptake and collagen production. | osteoporosis is a widespread problem afflicting millions of people. drynol cibotinis is a newly developed proprietary botanical combination of eight botanicals including angelica sinensis, glycine max, wild yam, ligustrum lucidum, astragalus membranaceus, cuscuta chinensis, psoraleae corylifoliae, and drynaria fortune. each of the botanicals has been used in traditional chinese medicine to treat osteoporosis. the effect of drynol cibotinis, with the specific combination of these anti-osteoporosi ... | 2010 | 19953582 |
| effect of astragalus membranaceus and angelica sinensis combined with enalapril in rats with obstructive uropathy. | ace inhibitors (acei) reduce renal tubulointerstitial fibrosis but are not completely effective. combined extract of astragalus membranaceus and angelica sinensis (a&a) is a traditional antifibrotic agent in china. the present investigation aimed to determine whether an acei (enalapril) and a&a together have a better antifibrotic effect in unilateral ureteral obstruction (uuo) than monotherapy with either agent. male sprague-dawley rats (n = 4 per group) had either sham operation or uuo alone, w ... | 2010 | 19960445 |
| [effects of astragalus membranaceus on cytokine secretion of peripheral dendritic cells in children with henoch-schonlein purpura in the acute phase]. | to explore the effects of astragalus membranaceus (am) on the cytokines secretion of peripheral dendritic cells (dc), including interleukin-10, -12, and -18 (il-10, il-12 and il-18), in children with henoch-schonlein purpura (hsp) in the acute phase; and to study the immunological regulation mechanism of am. | 2009 | 19960975 |
| [effects of inoculating am fungi on physiological characters and nutritional components of astragalus membranaceus under different n application levels]. | a pot culture with unsterilized soil as growth substrate showed that am fungi had significant effects on the growth of astragalus membranaceus (fabaceae) under different n application levels. inoculation with am fungi promoted the am infection of a. membranaceus roots, but high n application level suppressed the infection. inoculating am fungi increased the growth rate, soluble protein and sugar contents, and sod, pod and cat activities of a. membranaceus. under 50 and 100 mg x kg(-1) of n appli ... | 2009 | 20030131 |
| effects of cycloartane saponins from hairy roots of astragalus membranaceus bge., on human tumor cell targets. | for the first time three different natural compounds, isolated from hairy roots of astragalus membranaceus, cultivated in airlift bioreactor were tested for their cytotoxic potential and apoptosis induction in a panel of human tumor cell lines. root cultures, cultivated in bioreactor gave 18.5 g l(-1) dry wt roots with the highest astragaloside production in vitro up to now - 1.64% (astragaloside i), 1.12% (astragaloside ii) and 1.08% (astragaloside iii). in this manner the production in airlift ... | 2010 | 20060881 |
| [astragalus membranaceus improves endothelial-dependent vasodilator function in obese rats]. | to investigate the effect of astragalus membranaceus (am) on endothelial-dependent (edv) and non- dependent (eiv) vascular relaxation in ex vivo thoracic aortic rings of obese rats. | 2010 | 20117973 |
| biphasic positive effect of formononetin on metabolic activity of human normal and osteoarthritic subchondral osteoblasts. | osteoarthritis is a multifactorial disease characterized by loss of articular cartilage and subchondral plate thickening. therefore, biochemical analysis of the underlying bone tissue has provided important information for treatment of osteoarthritis. in this study, we determined the potential role of formononetin, a phytoestrogen isolated from astragalus membranaceus to alter the expression of metabolic markers and cytokine production of human normal osteoblasts (obs) and osteoarthritis subchon ... | 2010 | 20138155 |
| effect of astragalus membranaceus in rats on peripheral nerve regeneration: in vitro and in vivo studies. | this study provides in vitro and in vivo evaluation of astragalus membranaceus (am) on peripheral nerve regeneration. | 2010 | 20154555 |
| characterization of novel astragaloside malonates from radix astragali by hplc with esi quadrupole tof ms. | a structurally identified new compound named malonylastragaloside i was isolated and obtained from radix astragali. this novel compound was found to be unstable especially under high temperature and ph value. using sonication extraction, addition of formic acid, and an efficient medium pressure ods c(18) column chromatography method, a high yield of 40 mg of this compound was obtained from 150 g of powdered crude herbal medicine. malonylastragaloside i was structurally characterized by nmr and e ... | 2010 | 20162633 |
| geodermatophilus ruber sp. nov., isolated from rhizosphere soil of a medicinal plant. | a novel actinobacterial strain, designated cpcc 201356(t), was isolated from a rhizosphere soil sample of the medicinal plant astragalus membranaceus and subjected to a polyphasic taxonomic analysis. good growth occurred at 20-32 °c, at ph 7.0-7.5 and with 0-1 % (w/v) nacl. colonies on r2a and isp 2 agar were light red to red, round and lacked aerial mycelium; cells adhered to the agar. the peptidoglycan contained meso-diaminopimelic acid as the diagnostic diamino acid. the predominant menaquino ... | 2011 | 20190022 |
| altered expression of genes profiles modulated by a combination of astragali radix and angelicae sinensis radix in obstructed rat kidney. | the decoction of a combination of two chinese herbs, astragali radix (the roots of astragalus membranaceus var. mongholicus) and angelicae sinensis radix (the roots of angelica sinensis), here named as a&a, has been demonstrated to have renoprotective effects in several animal models and may be considered as a complementary therapeutic medicine for chronic kidney disease. in this study, genomic approaches were employed to identify expression signatures in the obstructed kidney, which may be link ... | 2010 | 20195958 |
| [study on extraction and purification of polysaccharides from astragalus membranaceus]. | to optimize the extraction and purification procedure for polysaccharides from astragalus membranaceus. | 2009 | 20218299 |
| comparison of the immunoregulatory function of different constituents in radix astragali and radix hedysari. | radix astragali (ra), known as "huangqi" in china, is one of the most popular herbal medicines known worldwide to reinforce "qi". ra is traditionally prepared from the dried roots of astragalus membranaceus (mjhq) and a. membranaceus var. mongholicus (mghq). radix hedysari is named "hongqi" (hq), which is similar to ra. we assessed and compared the chemical constituents and bioactivity of ra and hq. different constituents were extracted into five major parts and were analyzed using different met ... | 2010 | 20224658 |
| qi-shao-shuang-gan, a combination of astragalus membranaceus saponins with paeonia lactiflora glycosides, ameliorates polymicrobial sepsis induced by cecal ligation and puncture in mice. | the present study was performed to investigate the anti-septic effects of qi-shao-shuang-gan (qssg), a combination of astragalus membranaceus saponins (sam) and paeonia lactiflora glycosides (gpl), in septic mice induced by cecal ligation and puncture. qssg was shown to elevate the survival rate of mice, decrease infiltration of polymorphonuclear leukocytes into livers and lungs, lower serum levels of myeloperoxidase, nitric oxide, and lactate dehydrogenase, and decrease mrna expressions of indu ... | 2011 | 20237952 |
| remission of membranous nephropathy after therapy with astragalus membranaceus. | 2010 | 20338467 | |
| astragaloside iv improves homocysteine-induced acute phase endothelial dysfunction via antioxidation. | astragaloside iv, the major active component extracted from astragalus membranaceus, exerts multipotent activities under pathophysiological conditions. hyperhomocysteinemia, an independent risk factor for cardiovascular disease, induces oxidative stress leading to endothelial dysfunction. we investigated the effect of astragaloside iv on acute phase endothelial dysfunction induced by homocysteine. in a concentration-dependent manner, endothelial dysfunction was induced by homocysteine. in organ ... | 2010 | 20410599 |
| discrimination of geographical origin and adulteration of radix astragali using fourier transform infrared spectroscopy and chemometric methods. | radix astragali, one of most widely used and important traditional chinese medicines, is cultivated in different geographical regions. because of varying growing conditions, the qualities of radix astragali vary, which can give rise to differences in clinical therapy. detecting adulteration is a routine requirement in pharmaceutical practice. | 2012 | 20602337 |
| peroxyl radical scavenging capacity of extracts and isolated components from selected medicinal plants. | we determined the ability of extracts and active components isolated from nine medicinal plants, poncirus trifoliata, astragalus membranaceus, magnolia obovata, salvia miltiorrhiza, angelica dahurica, cornus officinalis, cnidium officinale, pueraria lobata and ostericum koreanum, to neutralize peroxyl radicals using the total oxyradical scavenging capacity (tosc) assay. peroxyl radicals were generated from thermal homolysis of 2,2'-azobis(2-methylpropionamidine) dihydrochloride, which oxidize al ... | 2010 | 20607491 |
| the protective effects of the traditional chinese herbs against renal damage induced by extracorporeal shock wave lithotripsy: a clinical study. | extracorporeal shock wave lithotripsy (eswl)-induced renal damage can occur as a result of multiple mechanisms. we have reported previously that astragalus membranaceus, salvia miltiorrhiza, a decoction of six drugs containing rhizoma rehmanniae preparata and supplements of a few traditional chinese medicinal herbs for invigorating the kidney and excreting calculus, have a protective effect on renal injury induced by high-energy shock waves (hesw) in rabbits. in this clinical study we further in ... | 2011 | 20607528 |
| herbal medicines for viral myocarditis. | herbal medicines are being used for treating viral diseases including viral myocarditis, and many controlled trials have been done to investigate their efficacy. | 2010 | 20614436 |
| preventive effects of a fractioned polysaccharide from a traditional chinese herbal medical formula (yu ping feng san) on carbon tetrachloride-induced hepatic fibrosis. | the study was to investigate the prevention effects and possible mechanism of yu ping feng san fractioned polysaccharide (ypf-p) on ccl(4)-induced liver fibrosis in rats. | 2010 | 20636883 |
| astragalus saponins modulate mtor and erk signaling to promote apoptosis through the extrinsic pathway in ht-29 colon cancer cells. | we have previously demonstrated that the total saponins of astragalus membranaceus (ast) possess potential anti-tumorigenic effects in human colon cancer cells and tumor xenografts. in the present study, the proapoptotic effects of ast were investigated in native and cytokine-induced ht-29 cells to further unveil its mechanism of action. growth-inhibitory action of ast (60 microg/ml) was demonstrated in native ht-29 cells, which was exaggerated in tumor necrosis factor (tnf) (5 ng/ml)-induced ce ... | 2010 | 20664949 |
| [transformation of astragaloside iv in bidirectional solid fermenting of astragalus membranaceus]. | to study the transformation of astragaloside iv in bidirectional solid fermenting of astragalus membranaceus var. mongholicus. | 2010 | 20681294 |
| [effects of heavy metal on astragalus membranaceus seeds germination and physiological target]. | to study the effects of heavy metals on germination and antioxidant systems of the seeds of astragalus membranaceus. | 2010 | 20707058 |
| [ecological environment of cultivated astragali radix and market specification of prepared slices]. | astragali radix is derived from roots of astragalus membranaceus var. mongholicus and a. membranaceus. the exhaustion of wild astragali radix has made cultivated astragali radix possess the commercial market of astragali radix. so the ecological environment of cultivated astragali radix should be investigated through field survey. through investigation, we found that a. membranaceus var. mongholicus are cultivated in hengshan mountain of shanxi province, longnan of gansu province, south of inner ... | 2010 | 20707062 |
| dna barcoding provides distinction between radix astragali and its adulterants. | based on variable nuclear and/or organellar dna sequences among vastly divergent species as well as morphologically indistinguishable species, dna barcoding is widely applicable in species identification, biodiversity studies, forensic analyses, and authentication of medicinal plants. the roots of astragalus membranaceus and a. membranaceus var. mongholica are commonly used as radix astragali in several asian countries, including china, japan, and korea. however, in addition to the two species r ... | 2010 | 20821298 |
| regulation of inflammatory gene expression in pbmcs by immunostimulatory botanicals. | many hundreds of botanicals are used in complementary and alternative medicine for therapeutic use as antimicrobials and immune stimulators. while there exists many centuries of anecdotal evidence and few clinical studies on the activity and efficacy of these botanicals, limited scientific evidence exists on the ability of these botanicals to modulate the immune and inflammatory responses. using botanogenomics (or herbogenomics), this study provides novel insight into inflammatory genes which ar ... | 2010 | 20838436 |
| meta-analysis of the clinical value of astragalus membranaceus in diabetic nephropathy. | nowadays diabetic nephropathy (dn) has become a serious problem. astragalus membranaceus is a traditional herb used for thousands of years in china and east asia for kidney disease. in modern medicine, astragalus shows significant renal protective effect in dn. we aimed to systematically review the randomized and semi-randomized control trials to ascertain its role in the treatment of dn. | 2011 | 20951192 |
| formononetin accelerates wound repair by the regulation of early growth response factor-1 transcription factor through the phosphorylation of the erk and p38 mapk pathways. | formononetin, a phytoestrogen from the root of astragalus membranaceus, is used as a blood enhancer and to improve blood microcirculation in complementary and alternative medicine. the present study investigated the influence of formononetin on the expression of early growth response factor-1 (egr-1) and growth factors contributing to wound healing. formononetin significantly increased growth factors such as transforming growth factor-beta 1 (tgf-β1), vascular endothelial growth factor (vegf), p ... | 2010 | 20959155 |
| the herbal formula ht042 induces longitudinal bone growth in adolescent female rats. | the effect of ht042, a blend of three herbal extracts, on longitudinal bone growth was investigated in short- and long-term rat models. in the short-term model, we divided female sprague-dawley rats (3 weeks old) into six groups, according to treatment: vehicle, ht042 (100 mg/kg), phlomis umbrosa (100 mg/kg), astragalus membranaceus (100 mg/kg), and eleutherococcus senticosus (100 mg/kg) were administered twice daily, and recombinant human growth hormone (rhgh) (1 iu) was subcutaneously injected ... | 2010 | 21091251 |
| astragalus membranaceus injection delayed allograft survival related with cd4+ cd25+ regulatory t cells. | recently it has been reported that astragalus membranaceus injection (ami) inhibits immune responses, but whether it affects alloimmunity is not clear. it has been shown that the cd4(+) cd25(+) regulatory t cells (treg) down-regulate immune responses. the aim of our study was to investigate the effects of ami on allograft survival and its relation to treg. | 2010 | 21094858 |
| inhibitory effects of two major isoflavonoids in radix astragali on high glucose-induced mesangial cells proliferation and ages-induced endothelial cells apoptosis. | radix astragali, the dried roots of astragalus membranaceus var. mongholicus, is well known to have a protective effect on diabetic nephropathy. however, the effects of isoflavonoids in radix astragali on glomerular cells, which play a key role in the development of diabetic vascular complications, remain largely unknown. thus, the purpose of this study was to investigate in vitro the effect of calycosin and calycosin-7-o- β-d-glucoside, two major isoflavonoids in radix astragali, on high glucos ... | 2010 | 21157685 |
| [the effect of astragalus membranaceus (fisch) bge. on lipid peroxidation and no level of myocardium from rats with diabetic nephropathy]. | to study the effect of astragalus membranaceus (fisch) bge. on the lipid peroxidation and no level of myocardium from rats with diabetic nephropathly. | 2001 | 21171416 |
| [effect of astragalus membranaceus on the proliferation, osteogenic capacity and structure of periodontal ligament cells in vitro]. | to investigate the effect of astragalus membranaceus (aps) on the proliferation, osteogenic capacity and structure of periodontal ligament cells (pdlcs) in vitro. | 2010 | 21179698 |
| biological analysis of herbal medicines used for the treatment of liver diseases. | herbal medicines have been used to treat liver disorders for thousands of years in the east and have now become a promising therapy internationally for pathological liver conditions. biological analysis of hepatoprotective herbs is an important issue from the pharmacokinetic perspective in developing new therapeutic managements for liver disease. the biological analysis focuses on the pretreatment methods, separation and quantification of herbal medicines in biological samples. we have compiled ... | 2011 | 21204110 |
| new isoflavonoid glycosides and related constituents from astragali radix ( astragalus membranaceus ) and their inhibitory activity on nitric oxide production. | twenty-four secondary metabolites, including 16 isoflavonoids, 7 astragalasides, and 1 benzoquinone, have been isolated from the roots of astragalus membranaceus (astragali radix). among these isolated isoflavonoids, (-)-methylinissolin 3-o-β-d-(6'-acetyl)-glucoside (1), (-)-methylinissolin 3-o-β-d-{6'-[(e)-but-2-enoyl]}-glucoside (2), and calycosin 7-o-β-d-(6''-acetyl)-glucoside (3) have been identified as new compounds on the basis of spectroscopic analysis; (-)-methylinissolin 3-o-β-d-glucosi ... | 2011 | 21280630 |
| [effect of astragalus membranaceus polysaccharide on the expression of inflammation cytokines in thp-1 cells]. | 2010 | 21328973 | |
| [effects of astragalus heteropolysaccharides on erythrocyte immune adherence function of mice with adjuvant-induced arthritis]. | astragalus heteropolysaccharides (ahps) is obtained from the dried roots of astragalus membranaceus (fisch.) bunge var. mongholious (bunge) hsiao. in the present study, we observed its effects on erythrocyte immune adherence function in mice with adjuvant-induced arthritis (aa). the mice were treated intragastrically with ahps of 1 000, 500, and 250 mg x kg(-1) x d(-1) separately and treated with tripterygium glycosides (tg) of 60 mg x kg(-1) x d(-1) as positive control. the number of complement ... | 2009 | 21351470 |
| [a taxonomic study on the original plant of radix astragali]. | there are dispute about the status of taxonomy among astragalus membranaceus (fisch.) bge, a. membranaceus (fisch.) bge. var. mongholicus (bge.) hsiao. and a. pallidipurpureus stat. nov. the varieties and taxa of the complex are still in need of revision. with molecular biology study used trnh-psba intergenic region, the taxonomic revision of radix astragali has been made. a. pallidipurpureus stat. nov is suggested as a new species. | 2009 | 21351481 |
| [protective effects of astragalus membranaceus on free fatty acid-induced vascular endothelial cell dysfunction]. | to investigate whether astragalus membranaceus (am) can protect endothelium-dependent vasodilatation (edv) function of aorta from the damage induced by high level of free fatty acid (ffa). | 2011 | 21355300 |
| xiang-qi-tang increases avian pathogenic escherichia coli-induced survival rate and regulates serum levels of tumor necrosis factor alpha, interleukin-1 and soluble endothelial protein c receptor in chicken. | xiang-qi-tang (xqt) is a chinese herbal formula containing rhizoma cyperi, andrographis paniculata and astragalus membranaceus. the present study investigated the effects of xqt on the mortality and inflammatory mediators in a chicken model challenged with avian pathogenic escherichia coli (apec). to detect the effect of xqt, the chickens were pretreated with the formula 12 h before being challenged with 10(8) colony forming unit (cfu) of apec. the results showed that 0.6 g/kg xqt significantly ... | 2011 | 21372388 |
| the telomerase activator ta-65 elongates short telomeres and increases health span of adult/old mice without increasing cancer incidence. | here, we show that a small-molecule activator of telomerase (ta-65) purified from the root of astragalus membranaceus is capable of increasing average telomere length and decreasing the percentage of critically short telomeres and of dna damage in haploinsufficient mouse embryonic fibroblasts (mefs) that harbor critically short telomeres and a single copy of the telomerase rna terc gene (g3 terc(+/-) mefs). importantly, ta-65 does not cause telomere elongation or rescue dna damage in similarly t ... | 2011 | 21426483 |
| astragalus membranaceus extract promotes neovascularisation by vegf pathway in rat model of ischemic injury. | astragalus membranaceus extract (ame) is a widely used herbal product for the treatment of cardiovascular diseases in china. the present study aimed to evaluate the cardiac protective effects of ame, and to probe the underlying molecular mechanism related to angiogenesis. in this study, ame with 75 microg/ml significantly increased proliferation, migration and tube formation on human umbilical vein endothelial cells (huvecs). moreover, in vivo experiments on rats with ligation of left anterior d ... | 2011 | 21434579 |
| ultraviolet irradiation induces accumulation of isoflavonoids and transcription of genes of enzymes involved in the calycosin-7-o-β-d-glucoside pathway in astragalus membranaceus bge. var. mongholicus (bge.) hsiao. | isoflavonoids are a group of phenolic secondary metabolites found almost exclusively in leguminous plants. formononetin, calycosin and calycosin-7-o-β-d-glucoside (cg) are isoflavonoid products in the cg pathway. accumulation of the three isoflavonoids plus daidzein and expression of six genes of enzymes involved in the cg pathway were studied in astragalus membranaceus bge. var. mongholicus (bge.) hsiao with ultraviolet (uv) irradiation. our results showed that (1) main isoflavonoids in roots, ... | 2011 | 21438882 |
| astragaloside iv inhibits adenovirus replication and apoptosis in a549 cells in vitro. | astragaloside iv, purified from the chinese medical herb astragalus membranaceus (fisch) bge and astragalus caspicus bieb, is an important natural product with multiple pharmacological actions. this study investigated the anti-advs effect of astragaloside iv on hadv-3 (human adenovirus type 3) in a549 cell. | 2011 | 21492171 |
| astragaloside iv attenuates impulse noise-induced trauma in guinea pig. | abstract conclusion. these results suggest that the beneficial effect of astragaloside iv on impulse noise-induced hearing loss may be due to its ability to inhibit inducible nitric oxide synthase (inos) and prevent the formation of reactive nitrogen species (rns). objective: astragaloside iv is the major active constituent of astragalus membranaceus, which has been widely used for the treatment of diseases in china due to its antioxidant properties. inos and rns are involved in damage induced b ... | 2011 | 21526907 |
| astragaloside iv improves metabolic syndrome and endothelium dysfunction in fructose-fed rats. | the prevalence of metabolic syndrome has increased in modern society and the condition is proving to be a common precursor of cardiovascular disease. the aim of the present study was to investigate whether astragaloside iv, a major active constituent of astragalus membranaceus (fisch) bge., is able to prevent the development of hypertension and endothelial dysfunction in fructose-fed rats. rats were fed with 10% fructose in their drinking water for 8 weeks. from the beginning of week 5, two grou ... | 2011 | 21555978 |
| astragaloside iv stimulates angiogenesis and increases hif-1{alpha} accumulation via pi3k/akt pathway. | astragaloside iv is the major active constituent of astragalus membranaceus, which has been widely used for the treatment of cardiovascular diseases in china. this study aims to determine the angiogenic effect of astragaloside iv and its underlying mechanism. we employed 3-(4,5-dimeth-ylthiazol-2-yl)-2,5-diphenyl-tetrazolium bromide (mtt) assay, western blotting, real-time pcr and immunofluorescence to detect the effect of astragaloside iv on proliferation of human umbilical vein endothelial cel ... | 2011 | 21576377 |
| [regulation of vitreoscilla hemoglobin on biosynthesis of astragaloside iv]. | in the present study, the regulation of vitreoscilla hemoglobin (vhb) on astragaloside iv biosynthesis was investigated. an intermediate expression vector consisting of the camv35s promoter fused to the vgb and nopaline synthase terminator was transferred into astragalus membranaceus via agrobacterium rhizogenes. the transgenic hairy roots were confirmed by pcr amplification and southern blot hybridization. the expression of vgb in transgenic hairy roots was confirmed by rt-pcr. after 15 days cu ... | 2011 | 21626794 |
| molecular cloning, characterization and expression of a chalcone reductase gene from astragalus membranaceus bge. var. mongholicus (bge.) hsiao. | a chalcone reductase (chr) gene was isolated from astragalus membranaceus bge. var. mongholicus (bge.) hsiao (a. mongholicus). the full-length cdna of a. mongholicus chr, designated as amchr (genbank accession no. hm357239), was 1196 bp long. it had a 957 bp open reading frame encoding a 318-amino acid protein of 35 kda, a 67 bp 5' non-coding region and a 172 bp 3'-untranslated region. the putative amchr protein showed striking similarity to chr from other leguminous species. two-dimensional str ... | 2011 | 21647549 |
| protection of chinese herbs against adenine-induced chronic renal failure in rats. | the aim of the study is to evaluate the efficacy of chinese herbs (angelica sinensis, ligusticum wallichii, salvia miltiorrhiza, rhizoma dioscoreae, rhodiola crenilata, astragalus membranaceus and angelica sinensis) on adenine-induced chronic renal failure in rats. 30 age-matched male wistar rats were divided into three groups. rats in group a (n = 10), b (n = 10) and c (n = 10) were fed a standard laboratory chow and allowed tap water ad libitum. in group b and c, renal failure was induced by t ... | 2010 | 21731165 |
| a ten-year audit of traditional chinese medicine and other natural product research published in the chinese medical journal (2000-2009). | clinical research encompasses a wide variety of disciplines. traditional chinese medicine (tcm) and natural product research have made great contributions to preventing and treating illness. the number and content of original research reports evaluating tcm and natural products have not previously been described. information in this area will identify areas of relative strength and weakness in terms of knowledge gaps with respect to clinical conditions and natural product remedies. | 2011 | 21740755 |
| antifibrotic effect of the chinese herbs modified danggui buxue decoction () on adriamycin-induced nephropathy in rats. | objective: to investigate the antifibrotic effect of the chinese herbs modified danggui buxue decoction (, mdbd) on adraimycin-induced nephropathy in rats. methods: thirty-two male sprague dawley albino rats were randomly divided into 4 groups: the control, model, and two treatment groups, with 8 in each group. nephropathy was induced in the latter 3 groups by intravenous injection of adriamycin. rats in the two treatment groups received intragastric administration of benazepri (a positive contr ... | 2011 | 21805297 |
| astragalus saponins modulate cell invasiveness and angiogenesis in human gastric adenocarcinoma cells. | aim of the study: we had reported that astragalus saponins (ast) exert promising anti-tumorigenic effects by suppressing the growth of ht-29 human colon cancer cells and tumor xenograft. in the present study, we further investigated the anti-angiogenic property of ast in human gastric adenocarcinoma cells (ags) and attempted to elucidate the underlying mechanism. materials and methods: viability of ags cells was measured by using the mtt reduction method. western blotting was performed to examin ... | 2011 | 21864667 |
| study of the relationship between genetics and geography in determining the quality of astragali radix. | astragali radix (ar), prepared from the roots of astragalus membranaceus (fisch. ex link) bunge or its variey, a. membranaceus (fisch. ex link) bunge var. mongholicus (bunge) hsiao., is one of the most used and valuable traditional chinese medicines (tcms). historically, hunyuan, shanxi province in china is the geo-authentic producing area of ar and crude ar from here called "geo-authentic." according to tradition, geo-authentic tcms define both authenticity and quality. however, no scientific i ... | 2011 | 21881225 |
| inhibition of polyglutamine-mediated proteotoxicity by astragalus membranaceus polysaccharide through the daf-16/foxo transcription factor in caenorhabditis elegans. | late-onset neurodegenerative diseases are characterized by progressive accumulation of aggregation-prone proteins and global disruption of the proteostasis network, e.g. abnormal polyq (polyglutamine) aggregation in huntington's disease. astragalus membranaceus polysaccharide (astragalan) has recently been shown to modulate aging and proteotoxic stress pathways. using caenorhabditis elegans models, we now show that astragalan not only reduces polyq aggregation, but also alleviates the associated ... | 2012 | 21892924 |
| Treatment with Astragalus membranaceus produces antioxidative effects and attenuates intestinal mucosa injury induced by intestinal ischemia-reperfusion in rats. | Astragalus membranaceus, also known as huang qi, a traditional Chinese medicine, is often used in formulas for deficiency of vital energy characterized by limb weakness, pale face, and dizziness. Previous studies have shown that Astragalus membranaceus could attenuate intestinal ischemia-reperfusion injury induced by hemorrhagic shock in rats; however, the underlying mechanism still remains unclear. Using a hemorrhagic shock rat model to examine the effect of Astragalus membranaceus on intestina ... | 2011 | 21905279 |
| astragalus polysaccharide injection integrated with vinorelbine and cisplatin for patients with advanced non-small cell lung cancer: effects on quality of life and survival. | a platinum-based two-drug regimen is currently the standard of care for patients with advanced non-small-cell lung cancer (nsclc). however, chemotherapy-induced side effects still remain a significant clinical problem. astragalus polysaccharide (aps) is a polysaccharide isolated from the radix of astragalus membranaceus, a commonly used herbal compound in traditional chinese medicine. aps was reported to increase tumor response, stabilize and improve performance status, and reduce chemotherapy t ... | 2012 | 21928106 |
| Studies on cell migration model in intestinal epithelial restitution for pharmacological research. | To set up a suitable IEC-6 migration model for pharmacological research and observe the effect of complex polysaccharide from Astragalus membranaceus (Fisch.) Bge. var. mongholicus (Bge.) Hsiao to IEC-6 cell migration. | 2011 | 21954562 |
| protective effect of astragaloside iv against matrix metalloproteinase-1 expression in ultraviolet-irradiated human dermal fibroblasts. | ultraviolet (uv) irradiation induces skin photoaging associated with up-regulated matrix metalloproteinase (mmp) expression. inhibition of mmp expression is suggested to alleviate photoaging induced by uv irradiation. astragaloside iv (as-iv), one of the main active ingredients of astragalus membranaceus (fisch) bge, has been reported to have various biological activities. however, its anti-photoaging effect has not been examined to date. in the present study, we observed the effect of as-iv on ... | 2011 | 21975818 |
| [comparative study of wild and cultivated astragali radix in daqingshan district in wuchuan of neimenggu]. | to make a comparative study on wild and cultivated astragali radix in wuchuan, neimenggu where is one of the geo-authentic producing areas of astragalus membranaceus var. mongholicus. | 2011 | 22007536 |
| Mesorhizobium silamurunense sp. nov., a novel species nodulated with Astragalus species in China. | Four rhizobial strains representing a previously defined novel group in the genus Mesorhizobium associated with Astragalus species in China were further characterized using a polyphasic approach. Phylogenetic analysis of 16S rRNA gene sequences showed that these Gram-negative bacteria belonged to the genus Mesorhizobium with Mesorhizobium plurifarium LMG 11892T as the closest neighbour sharing a sequence similarity of 99.8%. Polyphasic taxonomic methods including comparative sequence analysis of ... | 2011 | 22058324 |
| astragalus polysaccharides enhance the humoral and cellular immune responses of hepatitis b surface antigen vaccination through inhibiting the expression of transforming growth factor β and the frequency of regulatory t cells. | astragalus polysaccharides (aps), extracted from the root of astragalus membranaceus, a traditional chinese medicinal herb, have extensive pharmacological and strong immunomodulatory effects. in this study, the potential adjuvant effect of aps on humoral and cellular immune responses to hepatitis b subunit vaccine was investigated. coadministration of aps with recombinant hepatitis b surface antigen significantly increased antigen-specific antibody production, t-cell proliferation and ctl (cytot ... | 2011 | 22077226 |
| astragaloside iv attenuates complement membranous attack complex induced podocyte injury through the mapk pathway. | membranous nephropathy (mn) is the most common cause of idiopathic nephrotic syndrome in adults and the cause is known to be due to the injury of podocytes located in the glomeruli. astragalus membranaceus has been used for the treatment of patients with mn in china for a long time. the beneficial effect of astragalus membranaceus on proteinuria of patients with mn has been well documented. however, the mechanism of astragalus membranaceu in alleviation of mn is still not completely understood. ... | 2012 | 22086717 |
| a standardized extract from paeonia lactiflora and astragalus membranaceus attenuates liver fibrosis induced by porcine serum in rats. | paeonia lactiflora and astragalus membranaceus are two popular traditional chinese medicines, commonly used in chinese herb prescription to treat liver disease. the extract prepared from the roots of paeonia lactiflora and astragalus membranaceus (pae) demonstrated better hepatoprotective activity than the herbs used individually as shown in our previous studies. this study was carried out to investigate the effects of pae on liver fibr ... | 2011 | 22109673 |
| Danggui Buxue Tang attenuates eosinophil infiltration and airway hyperresponsiveness in asthmatic mice. | Danggui Buxue Tang (DBT), an herbal formula containing Angelica sinensis (AS) and Astragalus membranaceus (AM) (AS:AM = 1:5, designated as DBT1 here), has been used in Chinese medicine to enhance qi and blood circulation. In addition, DBT has served as a treatment for atopic dermatitis in dogs in Taiwan. It also may improve fibrosis in a rat model of pulmonary fibrosis. | 2011 | 22123379 |
| astragalus membranaceus lectin (aml) induces caspase-dependent apoptosis in human leukemia cells. | objectives: recently, plant lectins have attracted great interest due to their various biological activities such as anti-cancer, anti-fungal and anti-viral activities. we have reported earlier concerning anti-proliferation of human cancer cell lines by a galactose-binding lectin (aml), from a chinese herb, astragalus membranaceus. in the present study, detailed investigations into the mechanism of such anti-proliferation properties have been carried out. materials and methods: mechanism of ap ... | 2011 | 22172162 |
| in vitro effects of aqueous extracts of astragalus membranaceus and scutellaria baicalensis georgi on toxoplasma gondii. | toxoplasma gondii is a parasite that infects animals and humans worldwide. the standard treatment for toxoplasmosis is limiting due to toxic adverse effects, thus there is a need to identify new drugs that are less toxic. both astragalus membranaceus and scutellaria baicalensis georgi are popular traditional chinese herbs widely used for the treatment of various inflammatory diseases in asia, and we have previously demonstrated that water extracts of a. membranaceus (ame) and s. baicalensis geor ... | 2011 | 22179265 |
| astragaloside iv inhibits apoptotic cell death in the guinea pig cochlea exposed to impulse noise. | the results suggest that the beneficial effect of astragaloside iv on impulse noise-induced hearing loss may be due to its ability to inhibit reactive oxygen species (ros) and prevent apoptosis. | 2012 | 22217340 |
| nutrient and metal analyses of chinese herbal products marketed for veterinary use. | many chinese herbs and herbal mixtures are fed to domestic animals for their reputed medicinal properties. these herbs could contribute to the intake of essential nutrients and toxic metals, but their composition is mostly unknown. the purpose of this study was to measure major nutrient (crude protein, crude fat, carbohydrate, fibre) and mineral (ca, p, mg, k, na, fe, zn, cu, mn, mo, s, al, cd, ni, pb) concentrations in samples of fourteen combination formulas labelled for veterinary use and com ... | 2013 | 22289051 |
| metabolite profiling and pharmacokinetics of herbal compounds following oral administration of a cardiovascular multi-herb medicine (qishen yiqi pills) in rats. | qishen yiqi pills (qy pills) are a type of standardized cardiovascular herbal medicine, which contain four component herbs, i.e., astragalus membranaceus (huangqi), salvia miltiorrhiza (danshen), panax notoginseng (sanqi), and dalbergia odorifera (jiangxiang). after oral administration of qy pills, the in vivo exposure types of each component herb in rats were first uncovered and identified according to a target-directed strategy based on hyphenated chromatography techniques. the dominated metab ... | 2012 | 22292791 |
| herb-drug interaction of 50 chinese herbal medicines on cyp3a4 activity in vitro and in vivo. | the purpose of this study is to evaluate the effects of chinese herbal medicines on the enzymatic activity of cyp3a4 and the possible metabolism-based herb-drug interactions in human liver microsomes and in rats. fifty single-herbal preparations were screened for the activity of cyp3a4 using human liver microsomes for an in vitro probe reaction study. the enzymatic activity of cyp3a4 was estimated by determing the 6β-hydroxytestosterone metabolized from testosterone performed on a liquid chromat ... | 2012 | 22298448 |
| effects of jin-ying-tang on staphylococcus aureus-induced mastitis in rabbit. | the present study was performed to investigate the effects of jin-ying-tang (jyt), a chinese herbal formula containing lonicera japonica, herba taraxaci, fructus trichosanthis, fructus forsythia, radix et rhizoma rhei, astragalus membranaceus, angelica sinensis, on rabbit mastitis induced by staphylococcus aureus. suckling rabbits were challenged with 1.5 × 10(7) colony forming unit (cfu) of s. aureus at the base of the third pair teats, and they were treated and pretreated with jyt to detect th ... | 2012 | 22303901 |
| a novel infusible botanically-derived drug, pg2, for cancer-related fatigue: a phase ii double-blind, randomized placebo-controlled study. | this study investigated the efficacy of the botanical-derived drug, pg2, a partially purified extract of astragalus membranaceus, as a complementary and palliative medicine for managing cancer-related fatigue (crf). | 2012 | 22309959 |
| skeletal growth and igf levels in rats after ht042 treatment. | ht042, a new herbal prescription consisting of astragalus membranaceus, phlomis umbrosa and eleutherococcus senticosus, is used in traditional korean medicine to stimulate growth in children. this study was conducted to investigate the effects of ht042 on skeletal growth, insulin-like growth factor-1 (igf-1) and insulin-like growth factor binding protein-3 (igfbp-3) levels, and oestrogenic activity in female rats. female sprague-dawley rats were divided into control, recombinant human growth hor ... | 2012 | 22388791 |
| inhibitory effect of astragalus polysaccharides on lipopolysaccharide-induced tnf-a and il-1β production in thp-1 cells. | astragalus polysaccharides (aps), one of main bioactive components in astragalus membranaceus bunge, has been reported to possess anti-inflammatory activities, but the molecular mechanisms behind this activity are largely unknown. this study aimed to investigate expression of inflammatory cytokines and the mapk/nf-κb pathway in human thp-1 macrophages induced by lipopolysaccharide (lps). the results showed that the concentrations of tnf-a and il-1β released from lps stimulated thp-1 cells increa ... | 2012 | 22410422 |
| astragaloside iv regulates expression of atp-sensitive potassium channel subunits after ischemia-reperfusion in rat ventricular cardiomyocytes. | astragaloside iv (asiv) is the major effective component extracted from the chinese herb astragalus membranaceus, which has been widely used to treat cardiovascular disease. recent studies have shown that asiv can potentially protect the heart from myocardial ischemic injury, but the mechanisms of action are unknown. atp-sensitive potassium (katp) channels are activated during ischemia and exert a compensatory protective effect on cardiomyocytes. we therefore examined the effects of asiv on katp ... | 2011 | 22462239 |
| chinese herb astragalus membranaceus enhances recovery of hemorrhagic stroke: double-blind, placebo-controlled, randomized study. | we tested the effect of astragalus membranaceus (am) on acute hemorrhagic stroke. seventy-eight patients were randomly assigned to group a (3 g of am three times/day for 14 days); or group b (3 g of placebo herb). a total of 68 patients (group a 36, group b 32) completed the trial. the increase of functional independence measure scale score between baseline and week 4 was 24.53 ± 23.40, and between baseline and week 12 was 34.69 ± 28.89, in the group a was greater than 11.97 ± 11.48 and 23.94 ± ... | 2012 | 22474516 |
| inhibiting effect of astragalus polysaccharides on the functions of cd4+cd25 hightreg cells in the tumor microenvironment of human hepatocellular carcinoma. | astragalus polysaccharides (aps), the main active extract from astragalus membranaceus (a traditional chinese medicinal herb), is associated with a variety of immunomodulatory activities. the purpose of the present study was to examine the effect of aps on the function of treg cells in the tumor microenvironment of human hepatocellular carcinoma (hcc) and to identify the pharmacologic mechanism of aps responsible for the anti-chemotactic activity in cd4+cd25hightreg cells in tumor site of hcc. | 2012 | 22490576 |
| anti-atherosclerotic function of astragali radix extract: downregulation of adhesion molecules in vitro and in vivo. | atherosclerosis is considered to be a chronic inflammatory disease. astragali radix extract (are) is one of the major active ingredients extracted from the root of astragalus membranaceus bge. although are has an anti-inflammatory function, its anti-atherosclerotic effects and mechanisms have not yet been elucidated. | 2012 | 22536886 |
| astragalus membranaceus ameliorates reproductive toxicity induced by cyclophosphamide in male mice. | the root of astragalus membranaceus b(unge) (am) is a medicinal herb that has been capable of reducing the adverse effects of conventional chemotherapy. to investigate the effects of am on cyclophosphamide (cp)-induced reproductive toxicity in mouse testes, 5-week-old male imprinting control region mice were divided into five groups; cp was treated on the first day of each week for 5 weeks (100 mg/kg, i.p.), and am was treated for 5 days a week for 5 weeks. at the end of the treatment period, th ... | 2012 | 22674751 |
| isolation of anti-inflammatory fractions and compounds from the root of astragalus membranaceus. | foot ulceration, if not treated properly, will eventually result in amputation. inflammation may impede the wound healing process if not properly controlled. the root of astragalus membranaceus (ar) is one of the chinese herbs commonly found in chinese herbal formulae used for treating foot ulcer. in this study, we aimed to identify the active fractions and/or compounds from ar aqueous extract, which are responsible for the anti-inflammatory effect using in vitro bioassay-guided fractionation. t ... | 2013 | 22693074 |
| astragaloside iv downregulates β-catenin in rat keratinocytes to counter licl-induced inhibition of proliferation and migration. | re-epithelialization is a crucial step towards wound healing. the traditional chinese medicine, astragalus membranaceus (fisch) bge, has been used for hundreds of years for many kinds of ulcerated wounds. recent research has identified the active compound in this drug as astragaloside iv (as-iv), but the underlying molecular mechanisms of its therapeutic action on keratinocytes remain poorly understood. in this study, we used an in vitro model of ulcer-like wound processes, lithium chloride (lic ... | 2012 | 22693536 |
| astragalus embranaceus extract activates immune response in macrophages via heparanase. | astragalus membranaceus (am), a traditional chinese medicinal herb, has immunoregulatory properties in many diseases. we investigated the effects and mechanism of astragalus membranaceus extract (ame) in the macrophage migration and immune response mediator release. the viability of ana-1 macrophages treated with ame was evaluated by the mtt method. the secretion and mrna levels of il-1β and tnf-a were measured by elisa and rt-pcr, respectively. macrophage migration was assayed by transwell assa ... | 2012 | 22695229 |
| [modulation of aberrant extracellular matrix degradation systems by astragali radix and angelicae sinensis radix decoction (a&a) in interstitial fibrotic kidney]. | the imbalance between extracellular matrix (ecm) synthesis and degradation induces the excessive ecm deposition and thus renal fibrosis. the decoction (a&a) which is a combination of two chinese herbs, astragalus membranaceus var. mongholicus and angelica sinensis, has been shown to alleviate ecm production in animal models of chronic kidney diseases. in this paper, the effect of a&a on ecm degradation was investigated with interstitial fibrosis in rats. | 2012 | 22741467 |
| the effect of astragalin on the vegf production of cultured müller cells under high glucose conditions. | diabetic retinopathy (dr) is a severe complication of diabetes mellitus (dm) and often causes vision loss or even blindness. vascular endothelial growth factor (vegf) in the retina, which is mainly derived from müller cells, is a crucial biological factor in the development of dr. astragalin is extracted from astragalus membranaceus and has many pharmacological properties. studies showed that astragalin has beneficial effects on hyperglycemia. to evaluate the effect of astragalin in preventing a ... | 2012 | 22766709 |
| effects of astragalus polysaccharides on p-glycoprotein efflux pump function and protein expression in h22 hepatoma cells in vitro. | astragalus polysaccharides (aps) are active constituents of astragalus membranaceus. they have been widely studied, especially with respect to their immunopotentiating properties, their ability to counteract the side effects of chemotherapeutic drugs, and their anticancer properties. however, the mechanism by which aps inhibit cancer and the issue of whether that mechanism involves the reversal of multidrug resistance (mdr) is not completely clear. the present paper describes an investigation of ... | 2012 | 22784390 |
| [effects of astragalus membranaceus and potentilla discolor mixture on insulin resistance and its related mrna expressions in kkay mice with type 2 diabetes]. | to investigate the effects of astragalus membranaceus and potentilla discolor mixture (apm) on insulin resistance (ir) and mrna expressions of ir-related genes, including phosphatidylinositol 3-kinase (pi3-k), phosphoenolpyruvate carboxykinase (pepck) and peroxisome proliferator-activated receptor γ coactivator 1 (pgc1) in kkay mice with early type 2 diabetes and to explore the gene regulation mechanisms of amp. | 2012 | 22805090 |
| breastdefend™ prevents breast-to-lung cancer metastases in an orthotopic animal model of triple-negative human breast cancer. | we have recently demonstrated that a natural dietary supplement breastdefend (bd), which contains extracts from medicinal mushrooms (coriolus versicolor, ganoderma lucidum, phellinus linteus), medicinal herbs (scutellaria barbata, astragalus membranaceus, curcuma longa), and purified biologically active nutritional compounds (diindolylmethane and quercetin), inhibits proliferation and metastatic behavior of mda-mb-231 invasive human breast cancer cells in vitro. in the present study, we evaluate ... | 2012 | 22842551 |
| formononetin attenuates il-1β-induced apoptosis and nf-κb activation in ins-1 cells. | several studies suggest that the inflammation plays a role in the pathogenesis of some glucose disorders in adults. exposure of pancreatic β-cells to cytokines, such as interleukin-1β (il-1β), is thought to contribute to β-cell apoptosis. one important event triggered by il-1β is induction of nitric oxide synthase (inos), an enzyme that catalyzes intracellular generation of the cytotoxic free radical no. recent work have suggested that formononetin, as an o-methylated isoflavone found in a numbe ... | 2012 | 22922276 |
| astragalus membranaceus inhibits inflammation via phospho-p38 mitogen-activated protein kinase (mapk) and nuclear factor (nf)-κb pathways in advanced glycation end product-stimulated macrophages. | advanced glycation end products (ages) and inflammation contribute to the development of diabetic complications. astragalus membranaceus has properties of immunological regulation in many diseases. the aim of this study was to determine the function of a. membranaceus extract (ame) on the age-induced inflammatory response in ana-1 macrophages. the viability of cells treated with ame or ages was evaluated with the mtt [3-(4,5-dimethyl-2-thiazolyl)-2,5-diphenyl-2h-tetrazolium bromide] method. the ... | 2012 | 22942709 |