Publications
| Title | Abstract | Year Filter | PMID(sorted ascending) Filter |
|---|
| metabolite profiling of panax notoginseng using uplc-esi-ms. | the metabolite profiling of different parts of panax notoginseng was carried out using rapid ultra-performance liquid chromatography-electrospray ionization mass spectrometry (uplc-esi-ms) and multivariate statistical analysis. principal component analysis (pca) of the uplc-esi-ms data showed a clear separation of compositions among the flower buds, roots and rhizomes of p. notoginseng. the saponins accounting for such variations were identified through the corresponding loadings weights and wer ... | 2008 | 18550132 |
| effects of extracts from panax notoginseng and panax ginseng fruit on vascular endothelial cell proliferation and migration in vitro. | to study the effects of extracts from panax notoginseng (epn) and panax ginseng fruit (epgf) on the proliferation and migration of human umbilical vein endothelial cells (huvecs) in vitro. | 2008 | 18568327 |
| panax notoginseng saponins attenuate atherosclerosis in rats by regulating the blood lipid profile and an anti-inflammatory action. | previous studies have reported on the anti-atherosclerotic effects of panax notoginseng saponins (pns). the aim of the present study was to explore the molecular mechanisms responsible for the anti-atherosclerotic effects of pns and the inflammatory response. thirty rats were randomly divided into three groups, namely a control group, a group, in which zymosan a was used to induce inflammation (zym group) and a pns-treated group. rats in the three groups were administered liquid paraffin (i.p.), ... | 2008 | 18637019 |
| ultrasound phonophoresis of panax notoginseng improves the strength of repairing ligament: a rat model. | this study examined the phonophoretic effect of a therapeutic ultrasound coupled with a panax notoginseng (pn) gel and compared it with a therapeutic ultrasound alone for medial collateral ligament repair in rats. twenty mature male sprague-dawley rats receiving surgical transection to the left medial collateral ligament (mcl) were divided randomly into three groups: ultrasound (us, n = 7), ultrasound with pn coupling gel (pnus, n = 7) and control (n = 6). the treatments started on day 3 after s ... | 2008 | 18692299 |
| proteomic analysis of differential protein expression in rat platelets treated with notoginsengnosides. | sanqi, the root of panax notoginseng, is a popularly used traditional chinese medicine with cardiovascular effects. notoginsengnosides (ng) isolated from sanqi could inhibit adp-induced platelet aggregation of rat washed platelets. to identify the possible target proteins of ng in platelets, two-dimensional gel electrophoresis (2-de)-based comparative proteomics was performed and proteins altered in expressional level after ng treatment were identified by maldi-tof ms/ms. treatment of 200 microg ... | 2008 | 18706795 |
| panax notoginseng burk attenuates impairment of learning and memory functions and increases ed1, bdnf and beta-secretase immunoreactive cells in chronic stage ischemia-reperfusion injured rats. | panax notoginseng burk (pn) has been reported to improve blood circulation, as well as learning and memory functions. the purpose of the present study was to investigate the effect of pn on learning and memory functions in chronic cerebral infarct rats. a cerebral infarct animal model was established by blocking the blood flow of both common carotid arteries and right middle cerebral artery for 90 min followed by reperfusion for 4 weeks. pn (0.5 g/kg) was administered orally 3 days per week for ... | 2008 | 18711766 |
| botanical characteristics, pharmacological effects and medicinal components of korean panax ginseng c a meyer. | korean panax ginseng c a meyer is mainly used to maintain the homeostasis of the body, and the pharmacological efficacy of korean ginseng identified by modern science includes improved brain function, pain-relieving effects, preventive effects against tumors as well as anti-tumor activity, enhanced immune system function, anti-diabetic effects, enhanced liver function, adjusted blood pressure, anti-fatigue and anti-stress effects, improved climacteric disorder and sexual functions, as well as an ... | 2008 | 18718180 |
| biodiversity in cultivated panax notoginseng populations. | panax notoginseng is a cultivated ginseng species highly valued for its various pharmacological activities mostly associated with triterpenoid saponin glycosides. it would be of great interest to understand biodiversity in this ginseng species after its long history of domestication. | 2008 | 18718183 |
| rapid and sensitive analysis of multiple bioactive constituents in compound danshen preparations using lc-esi-tof-ms. | by fully optimizing the separation and analytical conditions, a rapid-resolution lc (rrlc, 1.8 microm particle size) coupled with tof-ms method was developed and validated for multiple compounds analysis of traditional chinese medicinal compound preparations (tcmcps). as a typical example, determination of compound danshen preparations (cdps, mainly comprising salvia miltiorrhiza and panax notoginseng), was improved on three groups of bioactive constituents (phenolic acids, diterpenoids, and sap ... | 2008 | 18763250 |
| a rapid ultra-performance liquid chromatography-electrospray ionisation mass spectrometric method for the analysis of saponins in the adventitious roots of panax notoginseng. | saponins are bioactive compounds employed in the prevention and treatment of cardiovascular and cerebrovascular diseases. the adventitious roots of panax notoginseng may offer an alternative source of saponins. identification and determination of saponins in the crude extract is challenging owing to their similar structures and the lack of standards. | 2009 | 18972457 |
| two new dammarane triterpene glycosides from the rhizomes of panax notoginseng. | two new dammarane triterpene glycosides named notoginsenosides rw 1 (1) and rw 2 (2) were isolated from the rhizomes of panax notoginseng, together with 20 known compounds including protopanaxadiol (3), protopanaxatriol (4), ginsenosides rb1 (5), rd (6), re (7), rg1 (8), rg2 (9), 20-(s)-rg3 (10), 20-(r)-rg(3) (11), rh1 (12), rh4 (13), rf (14), 20-o-glucopyranosyl rf (15), notoginsenosides r1 (16), r2 (17), t5 (18), s (19), t (20), and fa (21), and koryoginsenoside r1 (22). based on fabms, hrfabm ... | 2008 | 18985496 |
| influence of ginsenoside rg1, a panaxatriol saponin from panax notoginseng, on renal fibrosis in rats with unilateral ureteral obstruction. | total saponins of panax notoginseng (pns) have been shown to ameliorate renal interstitial fibrosis. ginsenoside rg1, a panaxatriol saponin, is one of the major active molecules from pns. the present study was undertaken to investigate the effect of ginsenoside rg1 on renal fibrosis in rats with unilateral ureteral obstruction (uuo). the rats were randomly divided into 3 groups: sham-operation (n=15), uuo (n=15) and uuo with ginsenoside rg1 treatment (n=15, 50 mg per kg body weight, intraperiton ... | 2008 | 18988308 |
| simultaneous determination of nucleobases, nucleosides and saponins in panax notoginseng using multiple columns high performance liquid chromatography. | a new multiple columns hplc method for simultaneous determination of 16 characteristic components, 5 nucleobases and nucleosides (uracil, cytidine, uridine, guanosine and adenosine), and 11 saponins (notoginsenoside r1, ginsenoside rg1, ginsenoside re, notoginsenoside r4, notoginsenoside fa, ginsenoside rb1, notoginsenoside r2, ginsenoside rg2, ginsenoside rh1, ginsenoside rd and notoginsenoside k), in the root of panax notoginseng, a valued traditional chinese medicinal herb, were developed. no ... | 2008 | 18995982 |
| improving effect of post-treatment with panax notoginseng saponins on lipopolysaccharide-induced microcirculatory disturbance in rat mesentery. | panax notoginseng saponin (pns) is the collective of the major effective components of panax notoginseng. the present study intended to explore the effect of post-treatment of pns on rat mesentery microcirculatory disturbance induced by lipopolysaccharide (lps) continuous challenge. by virtue of a microcirculation observation system, the vascular hemodynamics were determined continuously until 60 min of lps (2 mg/kg/h) infusion through the left femoral vein. after observation, blood was taken fo ... | 2008 | 19029637 |
| antiproliferative effects of different plant parts of panax notoginseng on sw480 human colorectal cancer cells. | the chemical constituents and antiproliferative effects on sw480 human colorectal cancer cells of different plant parts of p. notoginseng were evaluated. the contents of saponins in extracts from root, rhizome, flower and berry of p. notoginseng were determined using high performance liquid chromatography. the contents and proportions of saponins were different among the four plant parts. using the cell counting method, the antiproliferative effects were evaluated and the results indicated all f ... | 2009 | 19048608 |
| saponins isolated from the root of panax notoginseng showed significant anti-diabetic effects in kk-ay mice. | panax notoginseng, a well-known and commonly used traditional chinese herb, has been used in china for six hundred years. panax notoginseng saponins (pns) were extracted from the root of the plant. this is the first study on anti-hyperglycemic and anti-obese effects of pns in genetic model mice. additionally, the preventive effect on diabetic nephropathy was investigated. animals received intraperitoneal injections of pns 50 or 200 mg/kg daily. on day 12, 22 and 30, pns-treated groups had signif ... | 2008 | 19051359 |
| total saponins of panax notoginseng modulate the expression of caspases and attenuate apoptosis in rats following focal cerebral ischemia-reperfusion. | total saponins of panax notoginseng (tspn), main constituents extracted from panax notoginseng, a highly valued traditional chinese medicine, have been shown to be an effective agent on cerebral infarction. | 2009 | 19059471 |
| effect of sugar positions in ginsenosides and their inhibitory potency on na+/k+-atpase activity. | to determine whether ginsenosides with various sugar attachments may act as active components responsible for the cardiac therapeutic effects of ginseng and sanqi (the roots of panax ginseng and panax notoginseng) via the same molecular mechanism triggered by cardiac glycosides, such as ouabain and digoxin. | 2009 | 19060914 |
| ginsenoside rg1, a major active component isolated from panax notoginseng, restrains tubular epithelial to myofibroblast transition in vitro. | the medicinal herb, panax notoginseng, has been used for thousands of years in traditional chinese medicine and possesses anti-fibrosis properties. epithelial-myofibroblast transition (emt) plays an important role in renal tubulointerstitial fibrosis. the present study was designed to examine whether ginsenoside rg1, a major active component isolated from panax notoginseng, has an ability to block this phenotypic transition in rat renal tubular epithelial cells (nrk-52e) induced by transforming ... | 2009 | 19101622 |
| angiogenic effect of saponin extract from panax notoginseng on huvecs in vitro and zebrafish in vivo. | angiogenesis plays an important role in a wide range of physiological processes such as wound healing and fetal development. in fact, many diseases are associated with imbalance in the regulation of angiogenesis in which there is either excessive or insufficient blood vessel formation. panax notoginseng, a blood circulation invigorating herb, is commonly used in traditional chinese medicine to treat circulation-related diseases. however, the biological effects of saponin extract from panax notog ... | 2009 | 19107746 |
| [effect of total saponins from panax notoginseng on expession of melatonin receptor mrna in gastric mucosa of stress rats]. | to observe the effect of total saponins from panax notoginseng (pns) on melatonin receptor (mr) expression and its content in gastric mucosa of stress rats. | 2008 | 19112897 |
| anti-lung cancer effects of novel ginsenoside 25-och(3)-ppd. | 20(s)-25-methoxyl-dammarane-3beta, 12beta, 20-triol (25-och(3)-ppd), a newly identified natural product from panax notoginseng, exhibits activity against a variety of cancer cells. herein, we report the effects of this compound on human a549, h358, and h838 lung cancer cells, and compare these effects with a control lung epithelial cell line, beas-2b. 25-och(3)-ppd decreased survival, inhibited proliferation, and induced apoptosis and g1 cell cycle arrest in the lung cancer cell lines. the p. no ... | 2009 | 19131140 |
| [decolorization and purification of total leaves saponins of panax notoginseng with ion exchange resins]. | the total leaves saponins of panax notoginseng decoloring by adsorption with exchange resins was studied and the decoloring capacity of six anions resins as adsorbent material was evaluated. the decoloring capacity of the selected resins (d296 and dt) was compared by the dynamic adsorption decolorization experiments. removel of coloured compounds in rew solution takes place in two serially coupled different ionic exchange columns, one packed column was d72 cation resin, another anion resin. the ... | 2008 | 19157116 |
| flower extract of panax notoginseng attenuates lipopolysaccharide-induced inflammatory response via blocking of nf-kappab signaling pathway in murine macrophages. | the root of panax notoginseng (pn) is commonly used to treat chronic liver disease with its therapeutic abilities to stop haemorrhage in the circulation, while the pn flower (pn-f) is largely unknown in the biological activities on inflammation and mechanisms of its actions. in this study, the pharmacologic effects of pn-f methanol extract on inflammation were investigated to address potential therapeutic or toxic effects in lps-stimulated mouse macrophage cells, raw264.7 cells. | 2009 | 19162159 |
| phosphatidylinositol 3-kinase activity is required for the induction of differentiation in c6 glioma cells by panaxydol. | panaxydol isolated from the lipophilic fractions of tienchi ginseng (panax notoginseng) induces growth inhibition and differentiation of rat c6 glioma cells. the underlying molecular mechanisms are not completely understood. in the present study, we identified phosphatidylinositol 3-kinase (pi 3-k) as a necessary enzyme for the differentiation of c6 cells treated with panaxydol. the specific pi 3-k inhibitor wortmannin resulted in attenuated differentiation of c6 cells induced by panaxydol, and ... | 2009 | 19179079 |
| [effects of panax notoginseng saponins on antioxidation and preventing dna damage caused by hydroxyl radical]. | scavening effects of panax notoginseng saponins on active oxygen species in the systems of fenton reaction, autoxidation of pyrogallol and riboflavine photosensitization were investigated by the mean of spectrophotometry. the inhibition of panax notoginseg saponins on the damage of dna chain induced by hydroxyl radical by panax notoginseng saponins was observed by the mean of gelose gel electrophoresi and thiobartital spectrophotometry. the results showed that panax notoginseng saponins could sc ... | 2008 | 19180969 |
| [studies on separation and purification of total saponin from flower buds of panax notoginseng by macroporous resins]. | to optimize the technical parameters of separation and purification of total saponin from flower buds of panax notoginseng by macroporous resins. | 2008 | 19180974 |
| temporal expression of cyclooxygenase-2 in peritoneal macrophages of rats and effects of panax notoginseng saponins. | to explore the temporal expression pattern of cyclooxygenase (cox)-2 and effects of panax notogensing saponins (pns) in peritoneal macrophages of rats. | 2009 | 19184357 |
| identification of new trace triterpenoid saponins from the roots of panax notoginseng by high-performance liquid chromatography coupled with electrospray ionization tandem mass spectrometry. | triterpenoid saponins are the major bioactive constituents of panax notoginseng. in the study reported here, the fragmentation behavior of triterpenoid saponins from p. notoginseng was investigated by electrospray ionization tandem mass spectrometry (esi-ms(n))and high-performance liquid chromatography coupled with electrospray ionization tandem mass spectrometry (hplc/esi-ms(n)). analyses revealed that product ions from glycosidic and cross-ring cleavages can give a wealth of structural informa ... | 2009 | 19189343 |
| possible protection by notoginsenoside r1 against glutamate neurotoxicity mediated by n-methyl-d-aspartate receptors composed of an nr1/nr2b subunit assembly. | notoginsenoside r1 (ntr1) is the main active ingredient in panax notoginseng, a herbal medicine widely used in asia for years. the purpose of this study was to investigate pharmacological properties of ntr1 on neurotoxicity of glutamate (glu) in primary cultured mouse cortical neurons along with its possible mechanism of action. we found that ntr1 significantly protected neurons from the loss of cellular viability caused by brief exposure to 10 microm glu for 1 hr in a dose-dependent manner at c ... | 2009 | 19224577 |
| [cloning and characterization of cdna encoding psammosilene tunicoides squalene synthase]. | the total triterpene saponins of psammosilene tunicoides have significant pharmacologic activity. psammosilene tunicoides squalene synthase (pss) is a gateway enzyme to regulate the biosynthesis of total triterpene saponins extracted from the root of psammosilene tunicoides which is an endangered species. in this paper, cdna encoding of pss was cloned by the degenerate primer pcr and rapid-amplification of cdna ends (race). the full-length of cdna of pss is 1663 bp, with an open reading frame (o ... | 2008 | 19244758 |
| panax notoginseng attenuates the infarct volume in rat ischemic brain and the inflammatory response of microglia. | the roots of panax notoginseng (pn) are commonly used as a therapeutic agent to stop hemorrhage and as a tonic to promote health in traditional korean medicine. stroke triggers an inflammatory response that not only plays a central role in the pathogenesis of cerebral ischemia, but also induces secondary damage. this study was designed to investigate the neuroprotective effects of the methanol extract of pn on the infarct volume induced by middle cerebral artery occlusion (mcao) (90-min occlusio ... | 2009 | 19305121 |
| [effects of panax notoginseng saponins on expression of intercellular adhesion molecule-1 in human umbilical vein endothelial cells injury induced by oxidized low-density lipoprotein]. | to study the protective effect of panax notoginseng saponins (pns) on human umbilical vascular endothelial cells (huvecs) injury induced by oxidized low-density lipoprotein (ox-ldl) for investigating the mechanism of pns in treating arteriosclerosis obliterans (aso). | 2008 | 19317166 |
| ginsenoside-rd, a new voltage-independent ca2+ entry blocker, reverses basilar hypertrophic remodeling in stroke-prone renovascular hypertensive rats. | the total saponins of panax notoginseng have been clinically used for the treatment of cardiovascular diseases and stroke in china. our recent study has identified ginsenoside-rd, a purified component of total saponins of p. notoginseng, as an inhibitor to remarkably inhibit voltage-independent ca(2+) entry. we deduced a hypothesis that the inhibition of voltage-independent ca(2+) entry might contribute to its cerebrovascular benefits. ginsenoside-rd was administered to two-kidney, two-clip (2k2 ... | 2009 | 19374845 |
| anticancer activity of panax notoginseng extract 20(s)-25-och3-ppd: targetting beta-catenin signalling. | 1. the wnt/beta-catenin pathway plays a critical role in carcinogenesis and so agents that target wnt/beta-catenin may have potential in cancer prevention and therapy. the aim of the present study was to evaluate the anticancer activity of the novel natural product dammarane-type triterpene sapogenin (20(s)-25-och3-ppd; ppd25) isolated from the leaves of panax notoginseng. 2. the anticancer activity of ppd25 was evaluated in three colon cancer cell lines and in one lung cancer cell line. the eff ... | 2009 | 19413587 |
| [inhibitive effects of panax notoginseng saponins on expression of abeta(1-40), abeta(1-42) protein in samp8's brain]. | to observe inhibitive effects of panax notoginseng saponins on expression of abeta(1-40), abeta(1-42) protein in samp8's brain. | 2009 | 19445128 |
| danshen extracts decrease blood c reactive protein and prevent ischemic stroke recurrence: a controlled pilot study. | the efficacy of a danshen (salvia miltiorrhiza) dripping pill (ddp) for secondary stroke prevention was evaluated in patients with ischemic cerebrovascular disease. the preparation also contained panax notoginseng (sanqi) and dryobalanops camphor. patients who had suffered from ischemic stroke or a transient ischemic attack (tia) within the previous 20 days were managed according to established guidelines, and were divided into groups to receive either ddp or non-ddp treatment according to their ... | 2009 | 19449344 |
| induction of apoptosis in human lung carcinoma cells by the water extract of panax notoginseng is associated with the activation of caspase-3 through downregulation of akt. | the root of panax notoginseng is highly valued and commonly used in oriental medicine. although recent experimental data have revealed the proapoptotic potency of p. notoginseng extracts, the underlying molecular mechanisms of this apoptotic activity have not yet been studied in detail. in the present study, the effects of the water extract of p. notoginseng (wepn) on the growth of human lung carcinoma cells were investigated. it was found that the exposure of a549 and nic-h460 cells to wepn res ... | 2009 | 19513559 |
| ginsenoside rg1 protects rat cardiomyocyte from hypoxia/reoxygenation oxidative injury via antioxidant and intracellular calcium homeostasis. | ginsenoside rg1 is a major active ingredient of panax notoginseng radix which has demonstrated a number of pharmacological actions including a cardioprotective effect in vivo. this study investigated the protective effect and mechanism of ginsenoside rg1 in cardiomyocytes hypoxia/reoxygenation (h/r) model. pretreatment with ginsenoside rg1 (60-120 microm) reduced lactate dehydrogenase release and increased cell viability in a dose-dependent manner. fluorescence analysis demonstrated ginsenoside ... | 2009 | 19530220 |
| dammarane-type triterpene saponins from the flowers of panax notoginseng. | four new dammarane-type triterpene saponins named floranotoginsenosides a (1), b (2), c (3) and d (4), together with five known triterpene saponins, were isolated from the flowers of panax notoginseng. their structures were elucidated on the basis of spectral and chemical evidence. | 2009 | 19556938 |
| adjuvant activities of saponins from traditional chinese medicinal herbs. | new generation vaccines such as recombinant, antigen purified and dna vaccines are poorly immunogenic due to the lack of an innate immune stimulus. therefore, search of new adjuvants for these vaccines has become a topic of interesting. in new adjuvant development, saponins are outstanding candidates. recently, increased attention has been received on plant-derived saponins in search of new adjuvant candidates from traditional chinese medicinal herbs such as panax ginseng, astragalus species, pa ... | 2009 | 19559122 |
| [study on panax notoginseng mobilizing marrow stem cells efferens efficiency of acute myocardial infarction in rats]. | to study the mobilization efficiency effect on bone marrow stem cells by panax notoginseng on acute myocardial infarction in experimental rats. | 2009 | 19623990 |
| [effect of panax notoginseng saponins on vascular intima hyperplasia and pcna expression in rat aorta after balloon angioplasty]. | to explore the effect and the mechanism of panax notoginseng saponins (pns) on the vascular intima hyperplasia and expression of proliferating cell nuclear antigen (pcna) after aortic intima injury induced ballcon in rats. | 2009 | 19624018 |
| relationship between anti-fibrotic effect of panax notoginseng saponins and serum cytokines in rat hepatic fibrosis. | the aim of this study was to investigate the relationship between anti-fibrotic effect of panax notoginseng saponins (pns) and serum cytokines in rat hepatic fibrosis. hepatic fibrosis induced by carbon tetrachloride (ccl(4)) was studied in animal models using sd rats. liver index, serum alanine amino transferase (alt), aspartate amino transferase (ast), transforming growth factor-beta1 (tgf-beta1), tumour necrosis factor-alpha (tnf-alpha), interleukin-6 (il-6) and interleukin-10 (il-10) were me ... | 2009 | 19632202 |
| panax notoginseng saponins attenuate acute lung injury induced by intestinal ischaemia/reperfusion in rats. | acute lung injury remains a challenge for both clinicians and scientists. the effects of panax notoginseng saponins (pns) on acute lung injury induced by intestinal ischaemia/reperfusion (ii/r) were studied in rats. | 2009 | 19659831 |
| antiplatelet and anticoagulant effects of panax notoginseng: comparison of raw and steamed panax notoginseng with panax ginseng and panax quinquefolium. | ethnopharmacological significance: panax notoginseng (burk.) f. h. chen (araliacea) is traditionally used for its hemostatic and cardiovascular effects when raw and as a tonic when steamed. | 2009 | 19665534 |
| [effect of panax notoginseng saponins on syp and tau gene expression in brain of senescence accelerated mouse]. | to study the effect of panax notoginseng saponins (pns) on (synaptophysin, syp) and tau gene expression in the brain tissue in senescence accelerated mouse prone 8 (samp 8). | 2009 | 19673391 |
| total panax notoginsenosides prevent atherosclerosis in apolipoprotein e-knockout mice: role of downregulation of cd40 and mmp-9 expression. | total panax notoginsenosides (tpns) are the main active ingredients in san-chi, the root of panax notoginseng (burk) f.h. chen, which belongs to the araliaceae family and has been used in traditional chinese medicine to treat atherosclerosis. we investigated the effect of tpns on serum lipid levels and cell differentiation antigen 40 (cd40) and matrix metalloproteinase 9 (mmp-9) expression in atherosclerosis in apolipoprotein e-knockout (apoe-ko) mice fed a high-fat, high-cholesterol diet. twent ... | 2009 | 19703533 |
| panax notoginseng reduces atherosclerotic lesions in apoe-deficient mice and inhibits tnf-alpha-induced endothelial adhesion molecule expression and monocyte adhesion. | it is widely recognized that atherogenesis is associated with vascular inflammation. panax notoginseng , a commonly used herb in china, has been shown to possess anti-inflammatory activity. in the present study, the antiatherogenic effect of p. notoginseng saponins (pns) was examined in apolipoprotein e (apoe)-deficient mice. the molecular mechanisms responsible for the antivascular inflammatory effect of pns on human coronary artery endothelial cells (hcaecs) were also investigated in vitro. pn ... | 2009 | 19722574 |
| effect of total saponins of "panax notoginseng root" on aortic intimal hyperplasia and the expressions of cell cycle protein and extracellular matrix in rats. | the effect of total saponins of "panax notoginseng root" on aortic intimal hyperplasia and the expressions of cell cycle protein and extracellular matrix in rats | 2010 | 19748258 |
| [preparation and prescription of enteric coated pellets of panax notoginseng saponins pellets]. | to prepare enteric coated pellets containing panax notoginseng saponins. | 2009 | 19771862 |
| [mechanisms of delay endothelial cell replicative senescence by extracts from panax ginseng, panax notoginseng and ligusticum chuanxiong]. | to explore effect of extracts from panax ginseng, p. notoginseng and ligusticum chuanxiong on human umbilical endothelial cells (huvecs) replicative senescence. | 2009 | 19777843 |
| absorption and disposition of ginsenosides after oral administration of panax notoginseng extract to rats. | panax notoginseng (sanqi) is a cardiovascular herb containing ginsenosides that are believed to be responsible for the therapeutic effects of sanqi. the aim of this study was to evaluate rat exposure to ginsenosides after oral administration of sanqi extract and to identify the key factors affecting their absorption and disposition. ginsenosides were administered to rats, either in the form of sanqi extract or as pure chemicals. the ginsenosides ra(3), rb(1), rd, re, rg(1), and notoginsenoside r ... | 2009 | 19786509 |
| panaxatriol saponins extracted from panax notoginseng induces thioredoxin-1 and prevents 1-methyl-4-phenylpyridinium ion-induced neurotoxicity. | thioredoxin-1 has various biologic activities, including the control of redox balance and the inhibition of apoptosis. the current study was designed to examine the effects of panaxatriol saponins (pts) extracted from panax notoginseng on thioredoxin-1 expression and 1-methyl-4-phenylpyridinium ion-induced injury. | 2010 | 19857566 |
| [interaction between four herb compounds and a western drug by cyp3a4 enzyme metabolism in vitro]. | to explore the interaction between herbal medicines and western drugs based on cyp3a4 enzyme metabolism by using testotesrone as a probe in liver microsome metabolism system in vitro. | 2009 | 19873787 |
| inhibition of arterial myogenic responses by a mixed aqueous extract of salvia miltiorrhiza and panax notoginseng (pasel) showing antihypertensive effects. | the dried roots of danshen (salvia miltiorrhiza) and sanchi (panax notoginseng) have been widely used in traditional chinese medicine for promoting blood circulation as well as various other bodily functions. here we investigated the effects of a mixture of aqueous extracts of danshen and sanchi, named pasel, on blood pressure and vascular contractility in rats. orally administered pasel (62.5 mg/kg and 250 mg/kg, for 5 weeks) lowered the blood pressure of spontaneous hypertensive rats (shr) but ... | 2009 | 19885012 |
| effects of aif on knee osteoarthritis patients: double-blind, randomized placebo-controlled study. | anti-inflammatory factor (aif) is a water soluble extract of three herbs, panax notoginseng (burk.) f. h. chen, rehmannia glutinosa libosch and eleutherococcus senticosus. the present study aimed to investigate the safety and efficacy of herb extracts, aif, on korean knee osteoarthritis patients for six weeks. fifty seven patients with knee osteoarthritis, ranging from 43 to 73 years of age, who fulfilled the "american college of rheumatology" (acr) classification of idiopathic osteoarthritis of ... | 2009 | 19885024 |
| [effects of plasma containing buyang huanwu decoction and its effective components and total panax notoginseng saponins on vascular smooth muscle cell proliferation induced by platelet-derived growth factor]. | to explore the effects of plasma containing buyang huanwu decoction (byhwd), a compound of traditional chinese medicine, and its effective components (alkaloids and glycosides) and total panax notoginseng saponins (tspn) on vascular smooth muscle cell (vsmc) proliferation induced by platelet-derived growth factor (pdgf) in vitro. | 2009 | 19912742 |
| the effects and mechanism of saponins of panax notoginseng on glucose metabolism in 3t3-l1 cells. | this study was carried out to determine the effect of saponins of panax notoginseng (spn), a naturally occurring cardiovascular agent, on: (1) glucose uptake, (2) glut4 translocation and (3) glycogen synthesis in 3t3-l1 adipocytes. electrospray ionization-mass spectrometry (esi-ms) was used to determine the structural characterization of the major active components of spn. 3t3-l1 adipocytes were cultured and treated with 100 nm insulin alone or with 10, 50 and 100 microg/ml of spn. [(3)h]2-deoxy ... | 2009 | 19938225 |
| [effect of panax notoginseng on genes expression of cyp and gst in lung tissues of rats]. | to examine the effects of panax notoginseng on the expression of cytochrome p450 (cyp) genes and glutathione s-transferase (gst) genes in lung tissues of male sd rats. | 2009 | 19943494 |
| [effect of constituents combination on pharmacokinetics of shuxiong tablet]. | to study the effect of combination components on pharmacokinetics of shuxiong tablet to provide evidence for the new recipe. | 2009 | 19943495 |
| notoginsenoside r1 attenuates renal ischemia-reperfusion injury in rats. | ischemia-reperfusion (i/r) injury of the kidney is a complex pathophysiological process and a major cause of acute renal failure. it has been shown that i/r injury is related to inflammatory responses and activation of apoptotic pathways. inhibition of certain elements of inflammatory responses and apoptotic pathway seemed to ameliorate renal i/r injury. as an effective element of panax notoginseng, nr1 has antioxidant, anti-inflammatory, antiapoptotic, and immune-stimulatory activities. therefo ... | 2010 | 20023602 |
| [effect of panax notoginseng on genes expression of cyp and gst in liver tissues of rats]. | to examine the effects of panax notoginseng on the expression of cytochrome p450 (cyp) genes and glutathione s-trans-ferase (gst) genes in liver tissues of male sd rats. | 2009 | 20030096 |
| ultra-high performance liquid chromatography/time-of-flight mass spectrometry (uhplc/tofms) for time-dependent profiling of raw and steamed panax notoginseng. | the metabolic profiles of panax notoginseng and its associated therapeutic values are critically affected by the duration of steaming. the time-dependent steaming effect of p. notoginseng is not well-characterized and there is also no official guideline on its duration of steaming. in this paper, a uhplc/tofms-based metabolomic platform was developed for the qualitative profiling of multiparametric metabolic changes of raw p. notoginseng during the steaming process. our method was successful in ... | 2010 | 20079593 |
| [effects of panax notoginseng saponins on anti-hyperglycemic, anti-obese and prevention from kidney pathological changes in kk-ay mice]. | to observe the effects of panax notoginseng saponins (pns) on anti-hyperglycemic, anti-obese and prevention from kidney pathological changes in a type 2 diabetic kk-ay gene mice model. | 2009 | 20112724 |
| protective effects of ginsenoside rb(3) on oxygen and glucose deprivation-induced ischemic injury in pc12 cells. | to investigate the protective effects of ginsenoside rb(3), a triterpenoid saponin isolated from the leaves of panax notoginseng, on ischemic and reperfusion injury model of pc12 cells and elucidate the related mechanisms. | 2010 | 20140005 |
| panax notoginseng saponins protect rabbit bone marrow stromal cells from hydrogen peroxide-induced apoptosis. | to investigate the effects of panax notoginseng saponins (pnss) on hydrogen peroxide-induced apoptosis in rabbit bone marrow stromal cells (bmscs). | 2010 | 20141735 |
| component analysis and free radical-scavenging potential of panax notoginseng and carthamus tinctorius extracts. | panax notoginseng and carthamus tinctorius are known as traditional medicinal plants, and they also have edible values. to better understand their pharmacological mechanism, the present study assessed the in vitro antioxidant activities of extracts of p. notoginseng (epn) and c. tinctorius (ect). in addition, the main components of epn and ect were determined by hplc. the results show that epn mainly contained saponins, which were effective in scavenging (.)oh and o(.)(2-), while showing a low a ... | 2010 | 20151384 |
| a flavonol glycoside, isolated from roots of panax notoginseng, reduces amyloid-beta-induced neurotoxicity in cultured neurons: signaling transduction and drug development for alzheimer's disease. | a radix notoginseng flavonol glycoside (rnfg), quercetin 3-o-beta-d-xylopyranosyl-beta-d-galactopyranoside, was isolated from roots of panax notoginseng. among different biological properties tested, rnfg possessed a strong activity in preventing amyloid-beta (abeta)-induced cell death. in an in vitro assay, rnfg inhibited the aggregation of abeta in a dose-dependent manner. moreover, application of rnfg in cultured cortical neurons, or pc12 cells, reduced the abeta-induced cell death in time- a ... | 2010 | 20157237 |
| ginsenoside rg1 inhibits beta-secretase activity in vitro and protects against abeta-induced cytotoxicity in pc12 cells. | ginsenoside rg1 (1) is a major active component of panax notoginseng, a chinese herb widely used in traditional chinese medicine to improve learning and memory function. increasing evidence suggests that beta-amyloid peptide (abeta) plays a central role in the pathophysiology of alzheimer's disease (ad). to elucidate the mechanism of 1 on improving the ability of learning and memory, we investigated whether 1 could affect abeta generation or protect abeta-induced neurotoxicity. the results showe ... | 2009 | 20183297 |
| ginsenoside-rg1 from panax notoginseng prevents hepatic fibrosis induced by thioacetamide in rats. | panax notoginseng saponins have recently been reported to suppress liver fibrosis. since ginsenoside-rg1 is the most abundant component of p.notoginseng saponins, we investigated the effect of ginsenoside-rg1 on experimental liver fibrosis in rats. histological analysis revealed that ginsenoside-rg1 significantly improved the extent of liver fibrosis in rats induced by thioacetamide. ginsenoside-rg1 markedly suppressed the serum levels of fibrotic markers and hepatic hydroxyproline content in ra ... | 2010 | 20184879 |
| oligonucleotide microarray with a minimal number of probes for the detection and identification of thirteen genera of plant viruses. | a major challenge facing agriculture at present is the development of techniques that can screen field samples and other plant materials simultaneously for the presence of many viruses. microarray techniques show promise in this regard, as their high throughput nature can potentially detect a range of viruses using a single test. in this paper we present an array that can detect a wide spectrum of 169 plant virus species from 13 different genera. the array was constructed using an automated prob ... | 2010 | 20304013 |
| dynamics of carbendazim residue in panax notoginseng and soil. | to provide scientific information for gap of p. notoginseng and guiding the farmers and enterprises of chinese medicine, dynamics of carbendazim residue in the chinese medicinal herb, p. notoginseng and cultivated soil was studied at wenshan county in 2008. the half lives of carbendazim in p. notoginseng were 5.92-6.82 day (soil), 6.71-6.77 day (fresh leaf), 3.29-3.93 day (fresh root), and 31.50-36.67 day (powder of the dry root) separately. carbendazim residues in p. notoginseng were more stabl ... | 2010 | 20306171 |
| simultaneous determination of three major bioactive saponins of panax notoginseng using liquid chromatography-tandem mass spectrometry and a pharmacokinetic study. | panax notoginseng saponins (pns), the main active components of radix notoginseng, has been used for treating atherosclerosis, cerebral infarction, and cerebral ischemia. ginsenosides rg1, ginsenoside rb1, and notoginsenoside r1 are the main contributors of biological activities, determination of these three saponins is very important for the in vivo evaluation of pns. the present study aims to develop a liquid chromatography-tandem mass spectrometry (lc-ms/ms) method for the simultaneous quanti ... | 2010 | 20331853 |
| alleviation of ovariectomy-induced osteoporosis in rats by panax notoginseng saponins. | to examine the effects of panax notoginseng saponins (pns), the main active components of panax notoginseng, on ovariectomy-induced osteoporosis in rats. a total of 72 six-month-old female rats were randomly assigned to sham-operated group and five ovariectomized (ovx) groups: ovx with distilled water (5 ml/kg/day, p.o.), ovx with graded doses of pns (75, 150, 300 mg/kg/day, p.o.), and ovx with nilestriol (1 mg/kg/week, p.o.). animals were sacrificed after a 13-week treatment course. compared wi ... | 2010 | 20376572 |
| [determination of effective components in different positions of panax notoginseng by hplc]. | a quantitative method was developed by gradient elution for the determination of notoginsenoside r1, ginsenoside rg1, ginsenoside re and ginsenoside rb1 in different positions of panax notoginseng by hplc. the content of 4 kinds saponins in different positions of panax notoginseng were compared. | 2009 | 20432895 |
| anti-diabetic effects of panax notoginseng saponins and its major anti-hyperglycemic components. | panax notoginseng (burk) f.h. chen (araliaceae) is a well-known and commonly used traditional chinese herb for treatment of various diseases, such as hemostasis, edema and odynolysis. | 2010 | 20435129 |
| identification and molecular characterization of a new potyvirus from panax notoginseng. | a potyvirus causing distortion and mosaic symptoms in the herbal plant sanqi (panax notoginseng) was isolated from yunnan province, china, and the complete nucleotide sequence of one isolate and the partial sequences of two other isolates were determined. the viral rna genome comprised 9,750 nt excluding the 3'-terminal poly(a) tail, with the capacity to encode a single polyprotein of 3,089 amino acids. phylogenetic analysis with other completely sequenced potyviruses revealed that the virus in ... | 2010 | 20446003 |
| [effects of astragalosides and panax notoginseng saponins combination on oxidative stress of cerebral ischemic reperfusion injury in mice]. | to investigate the influence of astragalosides (ast) and panax notoginseng saponins (pns) combination on oxidative stress of brain tissues in c57bl/6 mice with cerebral ischemia-reperfusion injury. | 2010 | 20456843 |
| the influence of sam-chil-geun (panax notoginseng) on the serum lipid levels and inflammations of rats with hyperlipidemia induced by poloxamer-407. | atherosclerosis is characterized by the progressive deposition of lipids and inflammatory process. we attempted to develop a chemically-induced hyperlipidemic mice model, using poloxamer-407 and evaluated the lipid lowering and anti-inflammatory effect of p. notoginseng compared with that of atorvastatin, an antihyperlipidemic drug. | 2010 | 20499414 |
| [effects of panax notoginseng saponins on ace2 and tnf-alpha in rats with post-myocardial infarction-ventricular remodeling]. | to research the effects of panax notoginseng saponins (pns) on angiotensin-converting enzymes 2 ( ace2) and tumor necrosis factor-alpha (tnf-alpha) in rats with post-myocardial infarction ventricular remodeling. | 2010 | 20518313 |
| [effect of total saponins from rhizomes and flowers of panax notoginseng on tumor cell induced platelet aggregation]. | to investigate the effects of total saponins from rhizomes and flowers of panax notoginseng on tumor cell induced platelet aggregation (tcipa). | 2010 | 20518315 |
| biotransformation of ginsenoside rb1 to ginsenoside rd by highly substrate-tolerant paecilomyces bainier 229-7. | paecilomyces bainier 229-7 was obtained after uv irradiation for 8min in the presence of 0.4% licl and selection on potato dextrose media containing 30mg/ml saponin from panax notoginseng leaves (spnl). the mutant produces ginsenoside rd from ginsenoside rb1 with a bioconversion rate as high as 94.9% under optimized culture conditions in shake flasks when supplied with 20mg/ml of spnl. scale-up in 10-l fermenter resulted in an 89% bioconversion rate. ginsenoside rd was purified from the culture ... | 2010 | 20605716 |
| [effect of intracoronary injection with xuesaitong in treating post-pci slow-reflow phenomenon in patients with st-segment elevation myocardial infarction]. | to evaluate the effect and safety of xuesaitong (xst, a panax notonginseng extract preparation) via intracoronary injection for treating post-pci slow-reflow phenomenon in patients with st-segment elevation myocardial infarction (stemi) and its impact on patients' prognosis. | 2010 | 20669666 |
| antihepatocarcinoma activity of lactic acid bacteria fermented panax notoginseng. | panax notoginseng was used as the medium for lactic acid bacteria fermentation to manufacture product with antihepatocarcinoma activity. the fermentation broth prepared in a 250 ml erlenmeyer flask was found to possess antiproliferation activity against hepatoma hep3b cells. at the dosage of 500 microg/ml, the viability of hepatoma hep3b cells was approximately 2.2%. when the fermentation was scaled up to a 6.6 l fermenter, it was found that the fermentation broth produced at 37 degrees c for 2 ... | 2010 | 20681639 |
| panax notoginseng saponins attenuate atherogenesis accelerated by zymosan in rabbits. | panax notoginseng saponins (pns) are highly valued traditional chinese medicine. the effects of pns (120 mg/kg, once daily administrated intragastrically (i.g.)) on atherosclerosis induced by a high-cholesterol diet and chronic inflammation, which was derived through zymosan (10 mg/kg, once every 2 d) administration intraperitoneally, were evaluated in rabbits for 8 weeks. a normal group, a simple high-fat diet group, and a zymosan plus high-cholesterol diet group (zym) were used as controls. ty ... | 2010 | 20686226 |
| panax notoginseng saponins decrease cholesterol ester via up-regulating atp-binding cassette transporter a1 in foam cells. | accumulating evidence has indicated that panax notoginseng saponins (pns), the major ingredients in panax notoginseng (burk.) f.h. chen which could be found widely in asia, can attenuate atherogenesis in vivo. this study was designed to examine the relationship of pns with cholesterol ester in foam cells sourced from macrophages and the effect of pns on the expression of atp-binding cassette transporter a1 (abca1). | 2010 | 20727959 |
| [effects of panax notoginseng saponins on immune-neuroendocrine network of sd rats in experimental navigation and intensive exercise]. | the present study aims to study the influences experimental navigation and intensive exercise on immune-neuroendocrine network of the male rats and the effects of pns to this influence. | 2010 | 20815219 |
| protective effect of panaxatriol saponins extracted from panax notoginseng against mptp-induced neurotoxicity in vivo. | panaxatriol saponins (pts), the main constituents extracted from panax notoginseng, a chinese herbal medicine, has been shown to be an effective agent on various diseases. our previous study has demonstrated that pts is an inducer of thioredoxin-1 (trx-1) and has a possible potential as a therapeutic agent for parkinson's disease (pd). however, the effect of pts on 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (mptp)-induced neurotoxicity in vivo is unknown. | 2010 | 20951784 |
| anti-oxidative effects of the biennial flower of panax notoginseng against h2o2-induced cytotoxicity in cultured pc12 cells. | abstract: | 2010 | 21029415 |
| hypolipidemic and antioxidant activities of sanchi (radix notoginseng) in rats fed with a high fat diet. | sanchi, also known as radix notoginseng, is a chinese traditional medicine prepared from roots of the herb panax notoginseng. sanchi is traditionally used as a hemostatic to control internal and external bleeding but also shows diverse bioactivities that include increasing coronary blood flow and reducing myocardial oxygen consumption and blood pressure. although research into the potential cardioprotective effects of sanchi is ongoing in the field of traditional chinese medicine, we sought to e ... | 2010 | 21036582 |
| [action target of ginseng and panax notoginseng extracts on angiogenesis signaling pathway]. | to investigate the action targets of ginseng (gs) and panax notoginseng (pn), chinese herbs for benefiting qi and activating blood circulation, on angiogenesis signaling pathway (vegfr-2-ras-mapk) in human umbilical vein endothelial cells (huvec). | 2010 | 21038657 |
| [influence of astragalosides and panax notoginseng saponins compatibility on mmp-9 and timp-1 after cerebral ischemia-reperfusion in mice]. | to investigate the effect of astragalosides (ast) and panax notoginseng saponins (pns) compatibility on the expression of matrix metalloproteinases-9 (mmp-9) and tissue inhibitor of metal11oproteinase-1 (timp-1) after cerebral ischemia/reperfusion (i/r) injury in mice, to probe into its anti-ischemic brain injury protection mechanism. | 2010 | 21046759 |
| pharmacokinetics of panaxatrol disuccinate sodium, a novel anti-cancer drug from panax notoginseng, in healthy volunteers and patients with advanced solid tumors. | to evaluate single-dose and multiple-dose pharmacokinetics of panaxatrol disuccinate sodium in healthy volunteers and patients with advanced solid tumors. | 2010 | 21052087 |
| 5,6-didehydroginsenosides from the roots of panax notoginseng. | two minor novel dammarane-type saponins - 5,6-didehydroginsenoside rd (1) and 5,6-didehydroginsenoside rb1 (2) - were isolated from the dried roots of panax notoginseng along with sixteen known saponins. the structures of the new compounds were elucidated on the basis of spectroscopic and chemical methods. | 2010 | 21072027 |
| simultaneous determination of three panax notoginseng saponins at sub-nanograms by lc-ms/ms in dog plasma for pharmacokinetics of compound danshen tablets. | compound danshen tablets are composed of panax notoginseng, salvia miltiorrhiza and borneol. the tablets are prescribed for treatment of cardiovascular diseases in china. the present study aimed at developing a specific and sensitive lc-ms/ms method to simultaneously determine three bioactive p. notoginseng saponins, i.e., notoginsenoside r1, ginsenoside rg1 and rb1, in dogs after a single oral administration of the compound tablets in order to obtain the clinically relevant saponin-related phar ... | 2010 | 21081293 |
| traditional herbal remedies that influence cell adhesion molecule activity. | many traditional medicines have demonstrated immune activity, however, research has largely neglected their effects on cell adhesion molecules (cams). this review reports on extracts from 37 medicinal plant species, similar to or replicating traditional preparations, that up- or downregulate either gene or protein activity of cams. the majority of the investigations were in vitro, primarily of the immunoglobulin superfamily of cams, specifically intercellular cell adhesion molecule-1 (icam-1) an ... | 2010 | 21105177 |
| protective effects and mechanism of panax notoginseng saponins on oxidative stress-induced damage and apoptosis of rabbit bone marrow stromal cells. | to investigate the effects and possible mechanism of panax notoginseng saponins (pns) on oxidative stress-induced damage and apoptosis in bone marrow stromal cells (bmscs). | 2010 | 21110178 |
| ginsenoside-rd, a purified component from panax notoginseng saponins, prevents atherosclerosis in apoe knockout mice. | recently, it was revealed that the dysfunction of transmembrane ca(2+) transport, results in an increase in intracellular ca(2+)[ca(2+)](i), which is involved in the process of atherosclerosis. we previously demonstrated that ginsenoside-rd, a purified component from panax notoginseng, is a voltage-independent ca(2+) channels blocker. in this study, we investigated the effects of ginsenoside-rd on atherosclerosis and the underlying mechanisms in apolipoprotein e deficient (apoe(-/-)) mice and ra ... | 2010 | 21122802 |
| [experimental studies of panax notoginseng saponines and ginkgo biloba extracts on preventing acute oxygen toxicity]. | to investigate the preventive effects of panax notoginseng saponines (pns) and ginkgo biloba extracts (gbe) on acute oxygen toxicity and the possible mechanisms. | 2004 | 21166216 |