Publications
| Title | Abstract | Year Filter | PMID(sorted ascending) Filter |
|---|
| application of the turkey herpesvirus vaccine by the aerogenic route for the prevention of marek's disease. | recently in laboratory and field trials, birds were vaccinated with cell-free hvt vaccine by aerosol spray. in laboratory trials, birds vaccinated by aerosol spray were as well protected against challenge with virulent md (ga isolate) as those vaccinated by subcutaneous inoculation. birds were vaccinated with a sprayer (spraying systems company, wheaton, illinois) which emits a particle size in which 90% are less than microns. the chicks were sprayed with 1,000 to 10,000 pfu per bird dose and r ... | 1976 | 182596 |
| cause of "nakanuke" in chickens. i. occurrence of "nakanuke" in chicken inoculated with the cells showed coexistence or c-type virus and turkey herpesvirus. | 1975 | 183038 | |
| cause of "nakanuke" in chickens. ii. isolation of c-type virus from material infected with turkey herpesvirus. | 1975 | 183039 | |
| appearance in vivo of single-stranded complementary ends on parental herpesvirus dna. | intracellular forms of pseudorabies virus parental dna were examined before and after the onset of viral dna synthesis. before initiation of synthesis, parental viral dna acquires single-stranded ends. circular and concatemeric molecules are also observed, indicating that the single-stranded ends are complementary. viral dna replication is initiated at an internal site within the dna molecule, giving rise to characteristic replicative loops with single-stranded regions in the trans position. suc ... | 1976 | 183205 |
| virus peneumonia following measles: a virological and histological study of autopsy material. | adenovirus, measles virus and herpesvirus were found to be responsible for the serious non-bacterial bronchiolar and interstitial necrosis in post-measles pneumonia in underprivlieged non-white children less than 4 years of age in cape town. secondary bacterial bronchopneumonia, possibly antibiotically suppressed, proved to be less important in accounting for the extensive lung damage in 18 fatal cases that were examined virologically and histologically. | 1976 | 183294 |
| proteins of herpesvirus type 2. ii. studies demonstrating a correlation between a tumor-associated antigen (ag-4) and a virion protein. | 1976 | 183355 | |
| [differentiation of antibodies against turkey herpesvirus and 2 serotypes of marek's disease virus in the sera of farm chickens]. | 1976 | 183416 | |
| antibodies to adeno-associated satellite virus and herpes simplex in sera from cancer patients and normal adults. | the ecologic aspects of the distribution of adeno-associated satellite virus (asv) in the human population are of great interest because of its unconditional defectiveness and dependence on adenovirus for full and herpesvirus for partial complementation. adenoviruses and herpesviruses are extremely common and persistent infections in man. we have developed immunofluorescent procedures for detecting the presence of satellite virus antibodies in human sera. the percentage of sera with antibodies t ... | 1976 | 183503 |
| the mechanism of recurrent infection by herpesvirus hominis. | 1976 | 183607 | |
| [the neuronal torres bodies in experimental yellow fever encephalomyelitis. an additional example of the heterogeneous nature of cowdry type a intranuclear inclusions]. | in experimental yellow fever virus encephalomyelitis of adult albino mice, the occurrence of intranuclear inclusions within nerve cells, in particular, within spinal and bulbar motoneurons, is a constant finding. the light microscopic features of these so-called neuronal torres bodies correspond entirely to the criteria laid down by cowdry for the type a intranuclear inclusions. at the ultrastructural level, these karyoplasmic formations consist of haphazardly distributed patches of an essential ... | 1976 | 183626 |
| [herpesvirus-induced autoantibodies in animals (author's transl)]. | after immunization with autologous testicle cells which were infected with herpes virus hominis type 1 or 2, histologically homogeneous, eosinophilie pas-positive substances could be detected in five out of six rabbits, mainly within the interstitium. these substances have been found by immunofluorescence microscopic techniques to be antibodies against testicle tissue. | 1976 | 183633 |
| duck viral enteritis: a comparison of replication by ccl-141 and primary cultures of duck embryo fibroblasts. | cultures of primary cells and a line of fibroblast-like cells from the pekin duck were both compared for their replication of the herpesvirus of duck viral enteritis. the two kinds of cells were equally accurate for quantifying virus upon isolation. also, one-step growth curves showed that in both kinds of cultures new virus appeared by the 18th hour and that infectivity peaked at about 36 hours. primary cultures yielded about 5.6 times as much virus as did the cell line, though plaques were mor ... | 1976 | 183645 |
| marek's disease vaccine breaks: differences in viremia of vaccinated chickens between those with and without marek's disease. | viremia with turkey herpesvirus (hvt) and/or marek's disease (md) herpesvirus (mdhv) was examined in chickens from three different commercial flocks experiencing "vaccine breaks" following vaccination with hvt vaccine against md. in all groups of sample chickens from the flocks, the incidence of detectable hvt viremia was significantly less in the md-affected than in the healthy penmates, and incidence of md was significantly higher in the birds without detectable hvt viremia than in the viremic ... | 1976 | 183650 |
| the role of herpesvirus saimiri genomes in oncogenic transformation of primate cells. | 1975 | 183689 | |
| correspondence between t cell suppression and adlc titers during herpesvirus saimiri (hvs) infection in owl monkeys. | 1975 | 183696 | |
| lymphocyte responsiveness in squirrel, cebus and marmoset monkeys infected with herpesvirus saimiri. | 1975 | 183704 | |
| antilymphocytic factor derived from a herpesvirus saimiri lymphoid tumor cell line. | 1975 | 183705 | |
| reactivation of squirrel monkey heart isolate (herpesvirus saimiri strain) from latently infected human cell cultures and induction of malignant lymphoma in marmoset monkeys. | 1975 | 183706 | |
| induction of angioid sarcoma and fibrosarcoma by a guinea pig herpesvirus-transformed hamster cell line. | 1975 | 183707 | |
| regulation of herpesvirus gene expression in biochemical transformed cells: investigations of virus-specified regulatory functions. | 1975 | 183722 | |
| characterization of a spontaneous undifferentiated carcinoma from an african green monkey (cercopithecus aethiops). | an adult male african green monkey (cercopithecus aethiops) with an undifferentiated carcinoma, probably originating from the nasal mucosa, was received from the akron, ohio zoo. cultivation of this tumor in vitro resulted in a mixture of fibroblastic and epithelial cells which was subsequently separated using differential trypsinization. the neoplastic nature of the cultured epithelial cells was verified by their ability to transplant into athymic nude, or antithymocyte serum-treated mice, wher ... | 1976 | 184033 |
| morphological observations on the replication of herpesvirus saimiri in monkey kidney cell cultures. | owl and african green monkey kidney cell cultures have been infected with 1 p.f.u./cell of herpesvirus saimiri and sample cultures have been taken for examination by electron microscopy at 3 to 6 hourly intervals over a period of 7 days; the experiments were repeated several times. the peculiarly slow replication cycle of herpesvirus saimiri has enabled distinct cytoplasmic and nuclear phases in virus maturation to be clearly distinguished; the overall fine structural features were similar in bo ... | 1976 | 184242 |
| antigens and dna of a chimpanzee agent related to epstein-barr virus. | biological and biochemical studies of the herpesvirus of chimpanzees previously demonstrated to be antigenically related to human epstein-barr virus (ebv) indicated that the agent is similar to ebv in that: (i) leukocyte culture of chimpanzees whose sera contained antibody against ebv capsid antigen could yield long-term lymphoblastoid cell lines (ch-lcl) with b-cell characteristics; (ii) the dna of ch-lcl contained sequences homologous to approximately 35 to 45% of human ebv; (iii) ch-lcl conta ... | 1976 | 184297 |
| letter: mortalities in parma wallabies (macropus parma) associated with probable herpesvirus. | 1976 | 184775 | |
| effect of neutral red and light on herpesvirus hominis type 1 in cell culture. | various concentrations of neutral red were added to monolayers of muscle-skin fibroblasts after adsorption of herpesvirus hominis type 1. the concentration necessary to reduce plaque counts was found to be 10(-5.5) m. at the same time, the minimal toxic concentration of neutral red for muscle-skin fibroblasts was determined by the concentration that reduced the plaques of a challenge virus, vesicular stomatitis virus, that was applied after treatment with neutral red and light. the minimal toxic ... | 1976 | 185301 |
| cell surface antigens detected in cell lines established from lymphomatous papio hamadryas and macaca arctoides monkeys. | cell surface antigens associated with bone marrow cell cultures from leukemic monkeys of species papio hamadryas and macacus arctoides were visualized by means of an indirect immunofluorescence method with sera from leukemic baboons. the same immune serum gave two types of immunofluorescence, depending on the origin of the target cells. fluorescence of the ring-reaction type was seen with papio hamadryas bone marrow cell cultures growing in suspension and containing the baboon herpesvirus, where ... | 1976 | 185533 |
| herpesvirus hominis type ii infections in asymptomatic pregnant women. | this study was designed to determine the incidence of previous and current herpesvirus hominis type ii infections in asymptomatic pregnant women. sera were obtained from 985 patients for detection of type i and ii herpesvirus hominis antibodies. in addition 770 cervical and 211 amniotic fluid cultures for herpesvirus hominis type ii were performed. identification of previous herpesvirus hominis infection was determined in 352 patients (35.7%) by calculation of a type ii/i antibody index of 85 or ... | 1976 | 185552 |
| observed relationship between herpetic lesions and antigenic type of herpesvirus hominis. | of 171 available strains of herpesvirus hominis isolated in this laboratory during the period 1950 to 1975, 166 could be readily typed as hv-1 or hv-2 by indirect immunofluorescence, while 5 have so far been untypable. of 72 typable isolates from genitalia and nearby skin, all were hv-2. of 81 typable isolates from mouth, eye or skin above the waist, 68(84%) were hv-1 and 13(16%) were hv-2. of isolates from the eye only, 46 of 54(87%) were hv-1, 7(13%) were hv-2, and 1 could not be typed. when s ... | 1976 | 185733 |
| latent infections by herpes simplex virus in experimental animals. | studies in experimental animals, initially the rabbit and more recently the mouse, have been a great importance in establishing present day concepts concerning the phenomenon of herpesvirus latency. these early observations coupled with more recent knowledge of virological consequences following surgical manipulation of the trigeminal tract have led to a general hypothesis for the natural history of herpetic infections: the infection follows a circuit from skin, mucous membrane, or eye (the prim ... | 1976 | 185738 |
| immunology of herpesvirus infection: immunity to herpes simplex virus in eye infections. | a gereral, overall pattern of the temporal relationship and interaction between cell and antibody-mediated immune responses following herpes simplex virus infection of the rabbit cornea can be synthesized from our studies. cell-mediated immunity (cmi) appears early following infection, at a time when mononuclear and lymphocytic cellular proliferation occur at the limbus. interaction between specifically immune lymphocytes with virus antigens are detected by lymphocyte blastogenesis and migration ... | 1976 | 185741 |
| herpesvirus hominis type 2 meningoencephalitis following renal transplantation. | herpesvirus hominis (hvh) type 2 meningoencephalitis, confirmed by isolation of the virus from cerebrospinal fluid and brain biopsy specimens, is described in a 44 year old man following renal transplantation. an hvh type 2 genital infection developed two weeks after renal transplantation, which was followed by meningoencephalitis 10 days later. subsequently an intracerebral hemorrhage developed with evidence of diffuse vasculitis on arteriography. in a second transplant patient a similar clinic ... | 1976 | 185900 |
| antiviral effect of pyran against systemic infection of mice with herpes simplex virus type 2. | the immunomodulator pyran markedly protected 5-week-old mice from lethal intravenous infection with herpes simplex virus type 2. the 50% lethal dose was increased almost 100-fold in pyran-treated mice as compared with controls. although the protection was not as marked in older mice (10 and 16 weeks old), there was a significant increase in mean survival time. when the pathogenesis of herpesvirus disease was monitored in control and drug-treated mice, the effect of pyran was most evident in the ... | 1976 | 185945 |
| antiviral activity of bl-3849a, a low-molecular-weight oral interferon inducer. | oral administration of bl-3849a to adult mice resulted in peak serum interferon titers of 4,000 units from 15 to 30 h after administration, with detectable levels persisting until 48 h. after intraperitoneal (i.p.) inoculation, peak serum interferon titers of 1,000 to 3,000 units were noted between 9 and 18 h. multiple injections of the inducer by either route resulted in a marked decrease in the interferon response with each successive dose. in mice infected intranasally with the rochester mous ... | 1976 | 185953 |
| herpesvirus hominis hepatitis and disseminated intravascular coagulation. occurrence in an adult with pemphigus vulgaris. | herpesvirus hominis (hvh) hepatitis, a rarely recognized manifestation of hvh infection in adults, occurred in a 36-year-old woman who had received prednisone therapy for pemphigus vulgaris continuously for seven years. after an acute terminal illness that was characterized by fulminant hepatic failure and disseminated intravascular coagulation (dic), postmortem examination disclosed massive hepatic necrosis. herpesvirus hominis (type 1) was isolated from the liver. the association of disseminat ... | 1976 | 185974 |
| [cytological and histochemical studies on cell cultures infected with bovine herpesvirus type 2]. | cell cultures of embryonic calf kidney which had been infected with bovid herpes virus 2 were examined for cytological and histochemical changes. the morphological changes recorded from cells damaged by virus infection included the formation of gigant syncytial cells and intranuclear inclusions of cowdry type a. the cytological changes in the infected cells were accompanied by variation in enzyme activity. recordable were rise in lactate dehydrogenase and alkaline phosphatase as well as decline ... | 1976 | 185979 |
| equine herpesviruses: type 3 as an abortigenic agent. | the inoculation of equine herpesvirus type 3 (ehv3) strain 65/61 into the amniotic cavity of a mare 6-7 months pregnant resulted in abortion 11 days later. following abortion typical lesions of coital exanthema were not observed in the genital tract of the mare, nor was ehv3 isolated from her. serological evidence, however, indicated that the mare was infected with ehv3 following inoculation. grossly the foetal disease was characterised by placentitis, focal ulcerative dermatitis, focal necrosis ... | 1976 | 186003 |
| turkey herpesvirus infection in chickens: induction of lymphoproliferative lesions and characterization of vaccinal immunity against marek's disease. | chickens vaccinated at hatching with high doses of turkey herpesvirus (hvt) developed viremia that peaked in titer around the 12th day and gradually declined. hvt infection also induced mild microscopic lymphoproliferative lesions in the nerves and gonads. these lesions were most prominent around the 12th day and then regressed. the fact that such lesions were also induced by hvt in cyclophosphamide-treated chicks suggests that they were t-cell-dependent. some of the cells in early hvt lesions a ... | 1976 | 186008 |
| avian cell cultures grown in an open system (dishes) without co2 incubator, and their use for virus cultivation. | an organic buffer, n-2-hydroxyethylpiperazine-n'-2-ethanesulfonic acid (hepes), in a culture medium made it possible to culture chick embryo fibroblast (cef), duck embryo fibroblast (def), and chick kidney (ck) cells in an open system (dishes) under incubation in a bacteriological incubator, requiring no co2 incubation. cef, def, and ck cells cultured with this system were suitable for cultivation of avain viruses such as newcastle disease virus, celo virus, marek's disease virus, and turkey her ... | 1976 | 186014 |
| antibody responses to membrane antigens in monkeys infected with herpesvirus saimiri. | the antibody response to herpesvirus saimiri (hsv)-induced membrane antigens (ma) was followed in hsv-infected owl monkeys using the membrane immunofluorescence (mf) and antibody-dependent lymphocyte cytotoxicity (adlc) assays. these responses were correlated with the loss of t-cell responsiveness to general mitogens. antibody titers to ma as determined by adlc but not mf increased to remarkably high titers in those monkeys that developed malignant disease following virus infection, while remain ... | 1976 | 186415 |
| properties of a baboon lymphotropic herpesvirus related to epstein-barr virus. | three lymphoblastoid cell lines were established from splenic lymphocytes of a lymphomatous baboon (papio hamadryas) by co-cultivation of the lymphocytes with x-irradiated cells of marmoset or baboon lymphoblastoid cell cultures; the baboon splenic lymphocytes failed to grow when cultured alone. a herpesvirus, associated with each cell line, was identified by immunofluorescence, molecular hybridization and electron microscopy. antigenic comparison with epstein-barr virus (ebv) showed that the ba ... | 1976 | 186420 |
| chronic herpesvirus saimiri infection in an owl monkey. | an adult owl monkey (aotus tricirgatus) used for immunologic studies of herpesvirus saimiri (hvs) developed early, late, membrane, and neutralizing antibodies to hvs approximately 3 weeks after the beginning of the experiment. hvs was isolated by the cocultivation of peripheral blood for over 1 year. no clinical, gross, or histopathologic findings of malignancy were exhibited by the animal. the hvs isolate from the animal was indistinguishable biologically and serologically from the original hvs ... | 1976 | 186615 |
| horizontal transmission of turkey herpesvirus to chickens. 5. airborne transmission between chickens. | airborne transmission of turkey herpesvirus (hvt) between chickens was studied in two trials using an experimental line of white leghorns. hvt either did not spread or spread poorly to chickens that had been exposed for 8 weeks to the exhaust air from a cage containing donor chickens inoculated with hvt at 8 weeks of age. there was no airborne transmission of hvt to chickens that had been exposed for 4 weeks. this study indicated a possible by an infrequent spread of hvt between chickens via air ... | 1976 | 186771 |
| latent herpesvirus hominis from trigeminal and sacral dorsal root ganglia of cebus monkeys. | 1976 | 186804 | |
| herpesviruses and cancer in man and subhuman primates. | because there is strong evidence for the involvement of epstein-barr virus in the etiology of burkitt's lymphoma and nasopharyngeal carcinoma, we have discussed the relationship of epstein-barr virus to these two diseases in the context of geographic distribution, pathology, epidemiology, genetics, immunovirology, and biochemistry. we have also discussed the relationship of epstein-barr virus to other diseases, both malignant and non-malignant. although the etiologic relationship of herpes simpl ... | 1976 | 187259 |
| [cutaneous herpesvirus infections and malignant blood disorders. epidemiology]. | one hundred and ten skin infections with herpes virus were seen in a uniform group of 1,002 lymphoma-leukaemias dominated by non-hodgkin's lymphoma (385) and hodgkin's disease (327). they appeared with a significantly increased frequency in the course of hodgkin's disease, and between the ages of 60 and 69 for the other groups. in the hodgkin's cases they appeared characteristically during complete remission and in the others during the active phase of their disease. only exceptionally was there ... | 1976 | 187272 |
| inhibition of herpesvirus saimiri replication by phosphonoacetic acid, benzo(a)pyrene, and methylcholanthrene. | the present investigations were undertaken to determine the possible effects of two carcinogenic polycyclic aromatic hydrocarbons, benzo(a)pyrene and 3-methylcholanthrene on herpesvirus saimiri replication. the results from these experiments were compared with the effects of phosphonoacetic acid on the virus replication cycle. phosphonoacetic acid inhibited the synthesis of virus-induced intracellular late antigens, membrane antigens and infectious virus but not the synthesis of the early antige ... | 1977 | 187336 |
| herpesvirus saimiri-induced malignant lymphoma in rabbits. | of 9 new zealand white rabbits inoculated at multiple sc and im sites with a single dose of herpesvirus saimiri (hvs), 2 developed malignant lymphomas 40-50 days post inoculation. at least 1 animal developed a terminal leukemic phase of the disease. hvs was isolated from the oral and conjunctival swabs and blood and tissue lymphocytes, but not from monolayer cell cultures derived from kidney or lung tissues of the diseased animals. the inoculated rabbits developed low titers of neutralizing anti ... | 1976 | 187760 |
| characteristics of jmv marek's disease tumor: a nonproductively infected transplantable cell lacking in rescuable virus. | cells of the jmv marek's disease (md) tumor, originally produced by rapid serial passage of md lymphoma cells in chickens, were characterized to determine whether they were of host or donor origin and to ascertain certain virus-host cell interrelationships. differences noted in blood group b surface alloantigens between tumor cells and host lymphocytes indicated a probable nonhost origin (i.e., transplantability) of the tumor. jmv spleen tumors contained predominantly large lymphoblasts bearing ... | 1976 | 187779 |
| oncornavirus particles in lymphoid cultures from a howler monkey with herpesvirus saimiri-induced disease. | budding and extracellular oncornavirus particles were observed in cells of lymphoid cultures derived from the spleen, lymph node, and blood of a howler monkey (alouatta caraya) that developed a malignant lymphoproliferative disease after infection with herpesvirus saimiri. the various possible sources of origin of these particles are discussed. | 1976 | 187783 |
| mononuclear cell fraction carrying herpesvirus saimiri in persistently infected squirrel monkeys. | circulating lymphocytes from squirrel monkeys persistently infected with herpesvirus saimiri (hvs) were separated into b- and t-lymphocyte fractions by a rosette-enrichment technique. hvs was isolated only from lymphocyte fractions forming rosettes or from unseparated lymphocytes; this indicated that t-lymphocytes were the target cells for hvs in the natural host, squirrel monkeys. | 1976 | 187784 |
| [development and study of an experimental herpesvirus vaccine]. | the strains suitable for the development of herpesvirus vaccine were selected as a result of studies on numerous herpes virus strains isolated from patients with relapsing herpes infection of various localizations. infectious tissue culture antigens were obtained by roller cultivation of chick embryo fibroblast cultures infected with herpesvirus in the presence of 0.2% human serum albumin. a high immunogenic and antigenic activity of the experimental vaccines prepared from these antigens was est ... | 1976 | 188256 |
| infection of cattle with bovid herpesvirus. | 1976 | 188739 | |
| interferon induction by radioprotective mercaptoalkylamines and derived thiophosphates. | radioprotective thiols (five mercaptoalkylamines and four derived thiophosphates) induced interferon and resistance to virus infection. interferon production occurred in human and mouse nonlymphoid cell cultures. one of the thiols, s,2-aminoethylisothiourea, given intraperitoneally, protected mice against two unrelated viruses--semliki forest virus and herpesvirus hominis type 1. two structurally different radioprotective thiols--the disulfide cystamine and l-cysteine--were unable to induce the ... | 1977 | 188764 |
| sequential immunofluorescence and infectivity studies on the replication of herpesvirus saimiri in owl monkey kidney cells. | methods are described for the preparation and authentication of a highly specific antiserum against herpesvirus saimiri (hvs) capsid antigens. the antiserum was used in immunofluorescence tests to follow the development of capsid antigens in hvs-infected owl monkey kidney cells throughout the virus replication cycle in parallel with sequential titrations of virus infectivity in both cells and medium. fluorescence was detected as a round or oval, bright green area of staining at the centre of the ... | 1977 | 188981 |
| frog lysozyme. iv. isozyme of lysozyme and the lucké renal adenocarcinoma. | the normal kidney of the frog rana pipiens contains eight isozymes of lysozyme. three of these, however, were not present in five lucke renal adenocarcinomas. no isozymes were found to be unique to the tumor kidneys. of the five isozymes detected in tumor kidneys, only one was uniformly present, a second was present in four of five tumors, and the appearance of the other three was highly variable, although no tumor kidney contained all of them. the uniform absence of the three isozymes and the v ... | 1977 | 189053 |
| herpes simplex virus resistance and sensitivity to phosphonoacetic acid. | phosphonoacetic acid (paa) inhibited the synthesis of herpes simplex virus dna in infected cells and the activity of the virus-specific dna polymerase in vitro. in the presence of concentrations of paa sufficient to prevent virus growth and virus dna synthesis, normal amounts of early virus proteins (alpha- and beta-groups) were made, but late virus proteins (gamma-group) were reduced to less than 15% of amounts made in untreated infected cells. this residual paa-insensitive synthesis of gamma-p ... | 1977 | 189089 |
| herpesvirus infection. | 1977 | 189100 | |
| inoculation experiment of marek's disease vaccine contaminated with a reticuloendotheliosis virus. | two-day-old chicks were inoculated with one or ten doses of marek's disease (md) vaccine originated from the herpesvirus of turkeys (hvt) and contaminated with a reticuloendotheliosis virus (rev). as a result, they presented such symptoms as abnormality in the vane of remiges, undergrowth, anemia, and leg paralysis. these symptoms were the same as those induced by the same vaccine among chicks in the field. control chicks which had been placed in the same house as those inoculated with the vacci ... | 1976 | 189219 |
| demonstration of a herpesvirus from piglets with lesions of aujeszky's disease in new zealand. | 1976 | 189261 | |
| naturally-occurring neonatal canine herpesvirus infection. | the detailed clinical and epidemiological history and the pathology of neonatal canine herpesvirus (chv) disease in a naturally infected litter of pups is reported. herpesvirus was isolated from the brain, lung, liver, spleen, kidney and intestine of one of the affected litter which died on day 10 after whelping. the isolation of virus correlated with the distinctive gross and histological changes in these organs. herpesvirus was isolated also from the anterior vagina of the bitch 18 days after ... | 1976 | 189479 |
| in vitro cytotoxicity of serum and peripheral blood leukocytes for equine herpesvirus type 1-infected target cells. | the immune response in horses following experimental infection with equine herpesvirus type 1 (ehv-1) was assessed by measuring cytotoxicity for ehv-1-infected target cells. a technique was developed, using [125i]5-iodo-2'-deoxyuridine ([125i]iudr)-labeled equine fetal kidney cells infected with ehv-1 as the target cells. it was shown that peripheral blood leukocytes from a recovered horse were capable of lysing target cells, as measured by the loss of radio-active label. following the experimen ... | 1977 | 189645 |
| absence of horizontal transmission of herpesvirus saimiri between experimentally infected and noninfected owl monkeys. | we did not detect cell-free herpesviurs saimiri (hvs) in the oropharyngeal secretions of owl monkeys with leukemia or lymphoma induced by this virus. these animals failed to transmit either virus or disease to their uninoculated cage-mates or room-mates. comparison of oropharyngeal secretions of hvs from owl monkeys and squirrel monkeys may provide insight as to how human herpesviruses are maintained in the oropharynx. | 1976 | 189906 |
| persistence of herpesvirus nucleic acid in normal and transformed human cells - a review. | 1975 | 190112 | |
| structure and function of herpesvirus saimira dna. | two types of genomes are present in hvs stocks: (1) the defective h-genome consisting of highly reiterated heavy (71% c+g) sequences; and (2) the m-genome, which carries the whole genetic information of hvs and is infectious in tissue culture. the sequences in the m-genome are made up of 70% unique l-dna (with 36% c + g) and 30% h-dna, which is highly repetitive. h-sequences in the m-genome are clustered at the ends of the molecule. | 1975 | 190116 |
| studies of the dna of herpesvirus saimiri. | 1975 | 190117 | |
| partial purification and biochemical characterization of herpesvirus saimiri. | hvs propagated in vero cells was labelled with 3h-leucine and purified by isopycnic flotation in sucrose. electron microscopic examination revealed both complete and incomplete hvs. no significant contamination with cellular debris was noted. polyacrylamide gel electrophoresis analysis of solubilized virus revealed at least 12 proteins varying in molecular weight from 8 000 to 200 000 daltons. | 1975 | 190128 |
| altered fucolipid patterns in cells transformed by herpesvirus type 2. | 1975 | 190140 | |
| rna synthesis in cells infected with herpes simplex virus: analysis of high molecular weight and symmetrical viral transcripts in herpesvirus infected cells. | 1975 | 190144 | |
| some biological properties of herpesvirus saimiri from chronically infected monolayer and suspension cultures. | hvs-mest cells, which are adherent, produced more infectious hvs at 37 degress c than at 33 degrees c. this was paralleled by the appearance of ea and la in rounded cells and cf antigen in the cell cultures. in contrast, mlc-1 cells, which grow in suspension, produced hardly any infectious virus, but did produce more hvs s antigen than did the hvs-mest cells. production of s antigen in mlc-1 cells was augmented by treatment of the cells with budr. hvs-mest cells could be superinfected with hvs, ... | 1975 | 190156 |
| properties of the dna polymerase induced by marek's disease herpesvirus, strain ga, upon infection of duck embryo fibroblasts. | 1975 | 190161 | |
| persistent infection with bovine herpesvirus-1 (infectious bovine rhinotracheitis virus) in cultured hamster cells. | bovine herpesvirus-1 infection in hamster embryo cells was found to be dependent upon input multiplicity; productive infection was achieved at input multiplicities greater than one, while persistent infection was established when input multiplicities were about 0.5. this persistence was characterized by a noncyclic, minimal degree of cytopathic effect with a low level of released virus. maintenance of the persistently infected cultures did not require external supportive measures. subcultivation ... | 1976 | 190164 |
| herpesvirus infection and cervical anaplasia: a seroepidemiological study. | in a cohort of 23,146 pregnant females followed for 37-56 months subsequent to collection of prenatal sera, 57 cases of carcinoma of the cervix were encountered. three controls were selected for each case from the residual cohort matched to cases for age, residence, number of prior cytology smears taken, and the data of entry to the study. the antibody activity to herpesvirus type 1 and type 2 was examined by the indirect hemagglutination test. the proportion of cases positive for hsv-2 infectio ... | 1977 | 190174 |
| fatal generalized feline viral rhinotracheitis in a young adult cat. | a 7-month-old cat died following a 17-day illness. necropsy findings included sharply demarcated lingual ulcers and multifocal necrotic hepatitis. intranuclear inclusions were found in the lesions, and a herpesvirus was recovered from specimens of liver and tongue. the virus was identified by neutralization with specific antiserum as feline rhinotracheitis virus. | 1977 | 190195 |
| the direct antiviral cytotoxicity by bovine lymphocytes is not restricted by genetic incompatibility of lymphocytes and target cells. | experiments were designed to determine if in the ox a requirement for genetic compatibility between antiviral cytotoxic cells and target cells was needed for cytotoxicity to occur. unrelated bovine animals were immunized with vaccinia or ibr virus (a herpesvirus), and pbl were collected at various times for measurement of their cytotoxicity against autologous or heterologous uninfected or virus-infected fibroblasts. in all instances, cytotoxicity was expressed against heterologous as well as aut ... | 1977 | 190317 |
| experimental infection of monkeys with herpesvirus suis (aujeszky's-disease virus). | monkeys were infected intranasally with herpesvirus suis. after an incubation period of 7 to 13 days the animals became acutely ill and rapidly died. clinical signs included salivation, incoordination, ataxia and epileptiform convulsions, but not pruritus. histopathological changes were confined to the central nervous system, and consisted of destruction of neurones with the formation of intranuclear inclusion bodies, gliosis and perivascular cuffing. virus was isolated from the brain and spinal ... | 1977 | 190402 |
| viruses isolated from captive and free-ranging wild ruminants in alberta. | nasal secretions, leukocytes and preputial or vaginal swabs from a group of 15 captive wild ruminants, comprising six pronghorn antelope (antilocapra americana), seven fallow deer (dama dama) and two mule deer (odocoileus hemionus), and from 50 free-ranging pronghorns in southern alberta, were examined for viral agents. captive animals were given injections of dexamethasone daily for 6 days in attempts to reactivate latent infections. specimens were collected at 2-3 day intervals from days 0 to ... | 1977 | 190422 |
| herpesvirus sylvilagus in cottontail rabbits: evidence of shedding but not transplacental transmission. | herpesvirus sylvilagus was inoculated into five cottontail rabbits (sylvilagus floridanus) at various stages of pregnancy; they subsequently had litters in the laboratory. three other cottontails chronically infected with the virus were bred and bore young in large outdoor pens. thirty-four living neonates and dead fetuses were weighed, measured and aseptically necropsied. a total of 31 liver, spleen and kidney samples, 16 lymph node, 28 heart and 10 brain samples were collected and processed fo ... | 1977 | 190423 |
| herpesvirus sylvilagus in cottontail rabbits: attempted laboratory transmission by two insect species. | the vector potential of the rabbit flea (cediopsylla simplex) and a mosquito (aedes triseriatus) was investigated for herpesvirus sylvilagus transmission among cottontail rabbits (sylvilagus floridanus). twelve groups of 12-50 fleas were fed on three viremic cottontails for 2-21 days before transfer to 12 susceptible rabbits. standard interrupted feeding trials employed five groups of 6-12 mosquitoes, two viremic donor cottontails anf five healthy recipients. no evidence of virus was detected fr ... | 1977 | 190425 |
| microbial agents of the owl monkey (aotus trivirgatus). | a survey of the microbial flora in the owl monkey (aotus trivirgatus) has led to the isolation of numerous bacterial, fungal, and viral agents. some of the bacterial and fungal agents, particularly dermatophilus, pasteurella, salmonella, shigella, yersinia, streptococcus, staphylococcus, and candida are known pathogens. viruses belonging to the herpesvirus, adenovirus, paramyxovirus, and papovavirus groups have been isolated from the owl monkey. most of these viruses were recovered as latent age ... | 1976 | 190470 |
| the owl monkey (aotus trivirgatus) as an animal model for viral diseases and oncologic studies. | the owl monkey (aotus trivirgatus) has been shown to be an excellent model for studies of oncogenic and non-oncogenic viruses. studies at this institution have been primarily concerned with herpesvirus saimiri, the epstein-barr virus, h tamarinus, and h simplex. these studies have shown that h saimiri is oncogenic when inoculated into primates, that the malignancy induced by h saimiri can be naturally transmitted from the squirrel monkey to the owl monkey, that in vitro pathogenicity of h saimir ... | 1976 | 190472 |
| studies of cultured lymphocytes of the owl monkey (aotus trivirgatus) infected with herpesvirus saimiri. | the lymphocytes of five owl monkeys (aotus trivirgatus) infected with herpesvirus saimiri and three control monkeys were studied. lymphocytes were separated on ficoll-hypaque gradients, incubated in suspension cultures, and prepared for electron microscopic and immunofluorescent study at 24, 48, and 72 hours after the beginning of culture. buffy coats of whole blood obtained immediately after bleeding were also prepared for study. at the time of the study, four of the five infected monkeys had d ... | 1976 | 190473 |
| eb virus in the owl monkey (aotus trivirgatus). | owl monkeys (aotus trivirgatus) were inoculated with eb (epstein-barr) virus-containing material or virion-free control material. one out of three animals given the virus died after 14 weeks with a reticuloproliferative disease compatible with malignant lymphoma. a cell line was established from an abnormal lymph node of the diseased monkey and was found by electronmicroscopy to carry a herpesvirus identified as eb virus by two types of immunofluorescence test, by its biological behavior and by ... | 1976 | 190474 |
| measurement of antibodies to herpesvirus hominis by indirect immunofluorescent antibody method. | antibodies to herpesvirus hominis (hvh) were evaluated by indirect immunofluorescent antibody (fa) method. frozen sections of hvh infected mouse brain provided antigens for fa staining. our data indicate that indirect fa staining is a rapid, sensitive, and reproducible method for measurement of antibodies to hvh. indirect fa method can be applied as an additional tool for the measurement of antibodies to hvh and can be applied for epidemiological survey of hvh infections. | 1977 | 190522 |
| herpesvirus antigens. | 1977 | 190572 | |
| structure and function of herpesvirus genomes. ii. ecorl, sbal, and hindiii endonuclease cleavage sites on herpes simplex virus. | 1977 | 190767 | |
| herpesvirus transcription: altered regulation induced by fudr. | 1977 | 190769 | |
| [virus-induced autoimmunity phenomena in experimental animals (author's transl)]. | it may happen that the virus infection causes changes of the immunogenicity of the host cells that may theoretically result in disturbances of the "self-recognition" of the organism. in this paper we report on the immunization of rabbits by autologous testes cells infected with herpes-virus hominis (hvh) types 1 and 2. | 1977 | 191276 |
| a comparison of the pathogenicity of three strains of bovid herpesvirus 2 in calves. | the isolates of bovid herpesvirus 2 share common morphological, physical and antigenic features, but differences in their pathogenicity for cattle have been found among the strains. in order to investigate this aspect in more detail a comparative study was made of the skin lesions produced in calves by three strains of the virus: allerton ba, bovine mammilitis and 69/1l0. the results show that allerton ba was less pathogenic for calves than the other two strains used in the experiment. this conc ... | 1976 | 191339 |
| the gross and histological findings in the liver of pigs with aujeszky's disease. | the gross and histological changes were studied in the liver of young pigs naturally infected with aujeszky's disease. in the majority of the cases examined it was possible to detect small necrotic foci, scattered throughout the liver parenchyma, which corresponded histologically with intralobular or plurilobular areas of coagulative necrosis. at the periphery of the larger necrotic foci, inclusion bodies were also found in the hepatocytes of 9 of the 17 pigs examined. these intranuclear inclusi ... | 1976 | 191340 |
| ultrastructural and immunofluorescent studies of the replication of herpesvirus saimiri in cultured lymphocytes of infected owl monkeys. | the lymphocytes of five owl monkeys infected with herpesvirus saimiri (hvs) and of three control owl monkeys were studied by electron microscopic (em) and immunofluorescent (if) techniques. buffy coats of whole blood immediately after bleeding were also prepared for study. at the time of the study, two of the five infected monkeys were leukaemic; within 50 days after the study, four of the five had died with malignant lymphoma and lymphocytic leukaemia. hvs virions were demonstrated by em and hv ... | 1975 | 191352 |
| immunological aspects of herpesvirus infections in primates. | 1975 | 191354 | |
| induction of herpesvirus saimiri lymphoma in new zealand white rabbits inoculated intravenously. | 1975 | 191364 | |
| analysis and description of procedures used in the study of the relationship of herpes simplex virus "non-virion" antigens to certain cancers. | after a brief review of the relationship of herpes simplex viruses to certain human cancers, a description is given of procedures used in the study of herpesvirus "non-virion" antigens, and various points on which disagreement currently exists are discussed. complement-fixation tests on these markers with both cancer and control sera as well as with "non-virion" antisera, which did not react with non-anti-complementary stored virion antigens, are described, and it is suggested that another param ... | 1975 | 191373 |
| studies of the nature of herpesvirus-induced tumour-associated antigens induced by herpes simplex virus type 1 and further analysis of their relationship with squamous-cell carcinomas of the head and neck region. | the differences seen in levels of antibody response to hsv-taa between non-laryngeal and laryngeal cancers in cured and untreated patient populations were due to the use of filtered sera. in previous and present studies using unfiltered sera, these differences were not noted. of unfiltered sera from patients with squamous-cell carcinomas of the head and neck, 89% (49 out of 55) were positive for cf reactivity to hsv-taa, and 44% of these unfiltered sera had titres of 1:4 or greater to 44 microng ... | 1975 | 191376 |
| induction of serum antibodies in non-human primates with a killed oncogenic herpesvirus (herpesvirus saimiri). | 1975 | 191378 | |
| in vitro attenuation of herpesvirus saimiri by serial passage in dog fetal lung continuous cultures. | 1975 | 191379 | |
| herpesvirus type 2-induced tumour-specific antigen (ag-4) and specific antibody in patients with cervical cancer and controls. | 1975 | 191387 | |
| isolation from a transmissible lymphoid tumour (tlt) lymphoblastoid cell line of a herpesvirus similar to marek's disease virus. | a chicken lymphoblastoid cell line (tlt)-6855 originally established from an avian oncornavirus-induced lymphoma (siegfried and olson, 1972) was studied for the presence and expression of marek's disease virus (mdv) genome. by nucleic acid hybridization a significant amount of mdv dna was found in this cell line. this virus dna, however, was not expressed in either virus-specific intracellular or membrane antigens or the md-associated tumour-specific surface antigen (matsa). moreover, mdv-specif ... | 1977 | 191411 |
| the presence of herpesvirus saimiri genomes in virus-transformed cells. | herpesvirus saimiri (h. salmiri) -transformed cells contained both types of viral dna, unique l-dna and highly repetetive h-dna. dna from spleen and lymph-node autopsies of two tumor-bearing marmoset monkeys contained 0.14-0.75% viral l-dna -and 0.115-1.08% h-dna. this amount of h-dna would be equivalent to the presence of 14-130 m-genomes per diploid tumor tissue cell. six virus-transformed lymphoid cell lines, two of them virus-producing, contained 0.69-2.27% h-dna and more than 0.72-1.95% l-d ... | 1977 | 191414 |
| cell-mediated immune responses in recurrent herpesvirus infections. i. lymphocyte proliferation assay. | studies in immunosuppressed and immunodeficient patients indicate that the cell-mediated immune response appears to be responsible for controlling reactivated herpesvirus infections. in this study, the various parameters of a herpesvirus (types 1 and 2) antigen specific lymphocyte proliferation assay were optimized and used to evaluate individuals with clinical, recurrent hsv-1 and hsv-2 infections. normal individuals with neutralizing antibody to hsv-1 or hsv-2 responded to virus antigen in cul ... | 1977 | 191528 |