Publications
| Title | Abstract | Year Filter | PMID(sorted ascending) Filter |
|---|
| subacute sclerosing panencephalitis and multiple sclerosis: in vitro measles immunity and sensitization to myelin basic protein. | three children with subacute sclerosing panencephalitis (sspe), 12 patients with multiple sclerosis (ms) and 12 healthy persons were studied by the macrophage migration inhibition factor (mif) assay with measles and rubella antigens and with myelin basic protein. for the sspe patients the mean migration indexes +/- standard deviation were 44.1 +/- 10.9 for measles antigen, 38.7 +/- 12.3 for rubella antigen and 49.8 +/- 25.7 for myelin basic protein; for the ms patients the indexes were 103.0 +/- ... | 1978 | 343902 |
| demonstration of antibodies to measles virus by hemolysis-in-gel (hig) test. | 1978 | 345420 | |
| [the pathogenesis of multiple cerebrospinal sclerosis. present state of knowledge and concepts (author's transl)]. | 1978 | 350405 | |
| measles retinopathy during immunosuppression. | a 14-year-old boy had an acute attack of measles while on cytotoxic chemotherapy for a testicular neoplasm. two months later a fatal measles encephalopathy developed, verified by histological, ultrastructural, and immunofluorescent studies. ophthalmoscopy showed progression of flat depigmented areas of the retina as well as prominent lesions mimicking central serous retinopathy or retinitis. histopathological studies showed focal retinal necroses with invasion of pigment-laden macrophages into t ... | 1978 | 352388 |
| measles virus nucleocapsids: large-scale purification and use in radioimmunoassays. | nucleocapsids in quantities approaching 1 mg were purified from 109 measles virus-infected cells. they contained one polypeptide species with a molecular weight of 59,000. antiserum was raised in rabbits against purified nucleocapsids and used in a competitive radioimmunoassay. because of their instability, purified nucleocapsids were not suitable for use in such an assay. instead partially purified nucleocapsids from hep-2 cells persistently infected with measles virus and labeled in vitro with ... | 1978 | 352962 |
| [theories concerning the etiology of multiple sclerosis]. | 1977 | 355032 | |
| measles in africa: a deadly disease. some personal comments. | measles dominate childhood illnesses in tropical africa with a variety and severity of complications virtually unknown in the west. there is no apparent continental variation in measles virus but environmental factors vary widely. the frequent association of severe measles with malnutrition and recent studies indicating impaired humoral, cellular, and mucocutaneous immunologic function in the malnourished may explain this perplexing disease. prevention of early malnutrition combined with lasting ... | 1979 | 367677 |
| selective neuronal, dendritic, and postsynaptic localization of viral antigen in measles-infected mice. | the pathology of acute disease produced by intracerebral inoculation of hamster neurotropic strain of measles virus was studied in adult balb/c mice using immunolabeling techniques at a light and electron microscopic level. brains of animals with acute disease showed an abundance of viral antigen but no inflammatory cells, giant cells, or inclusions. infection was limited to neurons which were rarely necrotic, indicating that the process was not cytolytic. mapping of infected neurons identified ... | 1979 | 368437 |
| epidemiology of multiple sclerosis. | 1978 | 369331 | |
| cyclic expression of antigen and infectious virus in a bhk cell line (0-853) persistently infected with an sspe strain of measles virus. | establishment and characteristics of a baby hamster kidney cell line (bhk 0-853) persistently infected with a subacute sclerosing panencephalitis (sspe) strain of measles virus (lec strain) is described. the persistent infection was easily and repeatedly established and no special conditions were required. there was a predictable fluctuation in expression of virus intracellular and membrane antigens which varied from greater than 90% to less than 1% of the cells demonstrating these antigens duri ... | 1979 | 372496 |
| [preparation and characteristics of diploid cell strains from the tissues of a bovine embryo]. | two strains of diploid cells were prepared from the lung (bel-2) and skin-muscle (smbe-3) tissues of a bovine embryo. according to the results of morphological and karyological studies, these cultures consisted of fibroblast-like cells retaining diploid chromosome number (60) in the process of long-term cultivation. these cell populations have a limited life span (75-80 passages) and 3 growth phases. the species appurtenance of bel-2 and smbe-3 cells was confirmed. the cells were not contaminate ... | 1979 | 373247 |
| subacute sclerosing panencephalitis. immunological findings in saliva and salivary glands. | antimeasles antibody was detected in the saliva of 14 patients with subacute sclerosing panencephalitis. immunofluorescent staining showed antibody in salvary gland biopsy of 7 patients. | 1979 | 378668 |
| frequency, serodiagnosis and epidemiological features of subacute sclerosing panencephalitis (sspe) and epidemiology and vaccination policy for measles in the federal republic of germany (frg). | in the frg, sspe, a slow infection of the brain in children and young adults, known to be associated with a chronic measles virus infection, has an estimated incidence of 2.6 cases per million total population (61 million) and 9.7 cases per million population below the age of 19 years (16 million). in the 156 sspe cases between 1968 and 1977 the characteristic clinical, epidemiological and serological features were found. measles antibodies were present in the csf and the serum titers as measure ... | 1978 | 381072 |
| transmembrane communication in cells chronically infected with measles virus. | the transmembrane association of the measles virus hemagglutinin and hemolysin surface proteins with intracellular viral antigens was studied. rabbit antisera monospecific for measles virus matrix and nucleocapsid proteins and a human antiserum containing specificities for both the hemagglutinin and hemolysin proteins were used to study the co-capping of these proteins in human lu 106 cell-line, chronically infected with measles virus. capping of the surface-associated envelope components was ac ... | 1979 | 381319 |
| affinity for measles virus anti-haemolysin of a residual immunoglobulin m in sera of some patients with multiple sclerosis. | hep2 cells persistently infected with measles virus were treated with trypsin to remove haemagglutinin (ha) and examined unfixed or fixed in acetone by fluorescent antibody methods, comparing those sera specific for structural antigens of the virus. staining patterns combined with the blocking of specific immunofluorescence indicated that igg specific for measles virus haemolysin could be recognized in multiple sclerosis (ms) sera and that in some sera from which rheumatoid factor had been remov ... | 1979 | 383332 |
| detection of igg antibodies specific for measles virus by enzyme-linked immunosorbent assay (elisa). | a solid-phase, enzyme-linked immunosorbent assay (elisa) for determination of igg antibodies against measles virus is described. the assay utilized antigen-coated polystyrene microplates. the antigen consisted of a sonicated extract of measles-infected vero cells. goat and anti-human igg-peroxidase conjugate was used to detect human igg bound to viral antigen. sera taken from 63 healthy adults, 11 young children and 36 patients were evaluated for their igg titer against measles virus. comparison ... | 1979 | 387655 |
| antigen requirements, sensitivity, and specificity of enzyme immunoassays for measles and rubella viral antibodies. | enzyme immunoassay (eia) systems for measles virus and rubella virus were studied from the standpoints of requirements for suitable viral antigens and control antigens, and the sensitivity and specificity of the tests for detecting antibody elicited by past infection (determination of immunity status), and for serodiagnosis of currenet infections. crude or semipurified measles virus antigens were satisfactory for eia, but antigens derived by pelleting virus from infected cell culture fluids were ... | 1979 | 387813 |
| sspe: immunohistochemical demonstration of measles virus antigen(s) in paraffin sections. | we used the indirect immunoperoxidase method to study formalin-fixed, paraffin-embedded brain sections of four autopsied subacute sclerosing panencephalitis (sspe) patients. specific reactions with measles virus antigens was noted in all cases. positive staining was observed in neurons and glia cells and both nucleus and cytoplasm were usually stained in these positive cells. electron microscopy revealed intranuclear and intracytoplasmic nucleocapsids stained with electron-dense reaction product ... | 1979 | 388966 |
| detection of measles virus antigen(s) in peripheral lymphocytes from patients with subacute sclerosing panencephalitis. | peripheral blood lymphocytes from 5 patients with subacute sclerosing panencephalitis (sspe) were stimulated with phytohemagglutinin (pha) and analyzed for the presence of the measles virus antigen(s) by immunofluorescence (if). for detection of viral antigen fluorescein-conjugated globulins from sspe patients or from measles convalescents both with high anti-measles titer were used. peripheral blood lymphocytes from 5 children with measles were used as a positive control. measles virus antigen( ... | 1979 | 389202 |
| immunosuppressive measles encephalitis in a patient with a renal transplant. | an inclusion body encephalitis developed in a patient with a renal transplant that was shown by immunofluorescence and electron microscopic studies to be due to measles virus. measles encephalitis may be an opportunistic infection in children and adults with immunodeficiencies secondary to tumors or to the administration of immunosuppressive drugs. | 1979 | 389214 |
| the sensitivity of measles virus haemolysin to acetone and the preparation of mono-specific human anti-haemolysin by absorption. | the haemolysin of measles virus, either in the virion or in infected cells, is functionally and antigenically sensitive to acetone. absorption of human sera with acetone-treated, measles virus-infected cells removes antibodies to all measles virus structural antigens except haemolysin. the antibody titres of absorbed sera give good correlation in hli, neutralization and fluorescent antibody staining on unfixed infected cells. | 1979 | 392051 |
| [mechanisms of virus-induced and "allergic" demyelinations and their importance for the pathogenesis of multiple sclerosis. 2. the hosts reaction to virus-induced changes in the cns]. | 1979 | 396222 | |
| growth phase related loss of measles virus surface-associated antigens and cytotoxic susceptibility in persistently infected cells. | fluctuations in the expression of measles virus surface-associated antigens in persistently infected human lu 106 cells were analysed by the use of human sera which preferentially reacted with the haemolysin or haemagglutinin component. the variations observed correlated with the proportion of cells expressing surface-antigen, as examined in population analysis by indirect immunofluorescence, a radio-labelled antiglobulin technique and a cytotoxicity assay. microfluorometric analysis revealed no ... | 1979 | 396361 |
| [development of an erythrocyte diagnosticum for detecting measles antibodies]. | 1979 | 400545 | |
| complement activation by measles virus cytotoxic antibodies: alternative pathway c activation by hemagglutination-inhibition antibodies but classical activation by hemolysin antibodies. | antibodies against measles virus hemagglutinating (ha particles and hemolysin were shown to activate c differently. ha antibodies of rabbit or human origin activated c via the alternative pathway in cytotoxicity against chronically measles-infected cells. this cytotoxicity was expressed in c-4 deficient guinea-pig c or in rabbit c in the presence of 3 mm egta (ethylene-glycol-tetraacetic-acid) but not in 3 mm edta (ethylene-diamine-tetraacetic-acid). in contrast, human hemolysin antibodies activ ... | 1977 | 402419 |
| the role of defective interfering particles in persistent infection of vero cells by measles virus. | persistent infections by measles virus were rapidly established in the majority of vero cells when monolayers were infected with virus stocks that had been passed three to five times from an undiluted inoculum. these virus stocks had low infectivity titres but normal haemagglutinin titres and were able to cause interference. the ability of such virus stocks to establish persistent infections seems to be due to the presence of defective interfering particles rather than of virus mutants. measles ... | 1977 | 404394 |
| activity of lactate dehydrogenase, acid and alkaline phosphatases in measles virus-infected monkey kidney cell cultures. | the influence of wild (co-69) and attenuated (l-16) measles virus infection on the activity and activation energy of lactate dehydrogenase (ldh), acid and alkaline phosphatases (p-ase) was tested in r9ca monkey kidney cells at various time intervals after inoculation. with both virus strains significant changes in enzymatic activity occurred especially within the first 24 hours post inoculation. the two stains have a different influence on alkaline p-ase activity variation, which might therefore ... | 1977 | 405793 |
| imbalance of k/lambda ratios associated with high measles antibody titers in fractionated serum immunoglobulins of patients affected with subacute sclerosing panencephalitis. | subacute sclerosing panencephalitis (sspe) is a neurological disease which is characterized not only by the appearance of oligoclonal immunoglobulins in cerebrospinal fluid (csf) and serum but also by high measles antibody titers and disturbed k/lambda ratios, as well in serum as in csf. these findings lead to the hypothesis that specific immunoglobulins are produced by hyperimmunisation against measles and/or measles-like virus. therefore the serum igg from subacute sclerosing panencephalitis p ... | 1977 | 405900 |
| hemagglutination variant of measles virus. | 1977 | 407714 | |
| application of freeze-dried monkey erythrocytes to measles viral hemagglutination and hemagglutination-inhibition tests. | erthrocytes collected from monkey species including grivet, rhesus, and cynomolgus monkeys were stabilized by fixation with glutaraldehyde of a low concentration and were freeze-dried in vacuo. these freeze-dried erythrocytes were compared with fresh erythrocytes for measles viral hemagglutination and hemagglutination inhibition and could be used in both tests instead of fresh erythrocytes. they maintained their initial appearance and sensitivity to measles viral hemagglutinins after storage at ... | 1977 | 408375 |
| [slow infections: development of the problem and classification of the agents]. | 1977 | 408993 | |
| gel-precipitating measles virus antibodies in subacute sclerosing panencephalitis: relation to oligoclonal igg proteins in the cerebrospinal fluid and serum, and the occurrence of two separate fractions of antibody to virus nucleocapsids. | two to five separate gel-precipitating (gp) antibody activities to sonicated measles virus cell pack antigen were detected by double immunodiffusion and immunoelectrophoresis of sera and cerebrospinal fluids (csf) from patients with subacute sclerosing panencephalitis (sspe). the major gp activity was identified as antibody to measles virus nucleocapsids, and a weaker activity as antibody to the virus haemagglutinin. the specificities of the other activities were not determined. evidence is pres ... | 1977 | 411326 |
| isolation and characterization of a defective measles virus from brain biopsies of three patients in iran with subacute sclerosing panencephalitis. | three cytopathic strains of subacute sclerosing panencephalitis (sspe) virus were isolated from brain biopsies of three patients. these strains were isolated and maintained by cocultivation of infected brain cells with fresh vero cells. the biological characteristics of two strains were studied. it was found that these strains remain cell-associated after repeated cocultivations with vero cells and produce plaques under fluid medium or tragacanth overlay. the correlation with measles virus was d ... | 1978 | 412813 |
| subacute sclerosing panencephalitis. clinical and immunological investigations of two cases. | 1977 | 414898 | |
| idiotypy of measles virus nucleocapsid-specific iggkappa antibody in serum and cerebrospinal fluid in subacute sclerosing panencephalitis. | a gel-precipitating anti-idiotypic antiserum was prepared in a rabbit by immunization with measles virus-specific igg isolated from the serum of a patient with subacute sclerosing pancencephalitis (sspe). the idiotypic determinant was associated with an electrophoretically restricted and cathodally migrating iggkappa protein in serum and cerebrospinal fluid (csf) with antibody activity to measles nucleocapsids. the anti-idiotypic antiserum did not precipitate with other oligoclonal populations o ... | 1977 | 415354 |
| latent measles virus infection in vero cells depending on a temperature-sensitive phenomenon. | a latent infection by measles virus in a line of vero cells could be maintained only at 37 degrees c. the conditions of temperature nonpermissiveness were associated with some block in virus production and/or release and with the establishment of an autointerference phenomenon. reduction of the incubation temperature to 33.5 degrees c induced a rather rapid transition from the latent to a lytical infection with a recue of virus. the rescued virus exhibited a restricted capacity to grow at 37 deg ... | 1978 | 416813 |
| antibody-modification of measles "in vitro" infection. | while the involvement of measles-like virus with subacute sclerosing panencephalitis (sspe) has been shown in many laboratories, the possible mechanisms by which a normal measles infection may lead to the chronic condition are unclear. the work reported here demonstrates that the growth and maintenance of vero cells infected with the mv 30 strain of measles, in the presence of multivalent antibody, results in a redistribution of the viral antigens within the cells and an alteration in the proper ... | 1977 | 417148 |
| a paramyxovirus causing fatal gastroenterocolitis in marmoset monkeys. | a paramyxovirus has been isolated, identified and characterized. the virus causes a disease characterized clinically by severe diarrhea, dehydration and death. microscopically the disease is characterized as a proliferative gastroenterocolitis with focal necrosis of the mucosa, by giant syncytial cells and eosinophilic intranuclear and intracytoplasmic inclusions. the virus is closely related to measles virus antigenically. | 1978 | 417328 |
| familial multiple sclerosis: clinical, histocompatibility, and viral serological studies. | evaluation of presumed "multiple sclerosis families" and comparison with recently reported families has led us to the following observations: (1) seven of our original fourteen presumptive multiple sclerosis families had to be eliminated after personal clinical evaluation of family members failed to confirm the diagnosis in a second close relative. (2) no segregation of hla type was noted between affected and unaffected individuals in our seven bona fide multiple sclerosis families, and no consi ... | 1978 | 418737 |
| [measles--giant cell pneumonia]. | 1979 | 423752 | |
| influence of moderate malnutrition on morbidity and antibody response following vaccination with live, attenuated measles virus vaccine. | 1979 | 427297 | |
| a comparison of polypeptides in measles and sspe virus strains. | the polypeptide patterns of twelve subacute sclerosing panencephalitis (sspe) and measles viruses have been compared by slab gel electrophoresis. the polypeptide patterns of nine strains of sspe and measles virus were identical. differences in the np protein and the ha protein of the oddo strain, the p protein of the large plaque variant of the lec strain of sspe and in the m protein of the hu 2 measles strain could not be correlated with biological characteristics such as plaque morphology, ori ... | 1979 | 430032 |
| postvaccine era measles epidemiology. | measles incidence in the united states was calculated from estimates of the united states immunization survey for the years 1965 to 1975. these data were examined according to birth cohorts and cross-sectionally by age to determine the effect of live measles virus vaccine on measles epidemiology. the results showed a high rate of infection for children aged 1 year, followed by a decrease in the infection rates for preschool children, with rates increasing agin at ages 5 and 6 years. it was hypot ... | 1979 | 430684 |
| igg synthesis within the brain in multiple sclerosis and subacute sclerosing panencephalitis. | intracerebral igg synthesis was measured in patients with multiple sclerosis (ms), subacute sclerosing panencephalitis (sspe) and in two control groups--patients with other neurological disorders and patients with non-neurological diseases. significantly increased synthesis was found at all times in sspe (p less than 0.001). significantly elevated values were also found in ms (p less than 0.001), but in this group increased values were found mainly during relapse. these findings emphasize the im ... | 1979 | 436336 |
| neutralizing antibodies to canine distemper and measles virus in multiple sclerosis. | serum neutralizing antibody to canine distemper virus (cdv) was measured in 142 patients with multiple sclerosis (ms), an equal number of age and sex-matched normal controls, and 75 patients with other neurological disorders. an elevated antibody titer was found in the ms population compared to controls. measles-neutralizing antibody was also found to be elevated in 128 patients with ms. the mean ratio of measles to cdv antibody was similar in the control and ms groups, but a wide range of measl ... | 1979 | 438844 |
| pneumonia of atypical measles. | infection with rubeola virus after previous immunization with killed measles virus vaccine produced abnormal chest radiographs in 9 patients. variable pneumonic consolidation occurred in all cases and was mainly lobar or segmental in distribution. four patients had hilar adenopathy, 3 pleural effusion, and in 1 instance a pulmonary nodule remained 9 months after clearing of the acute pneumonia. atypical measles pneumonia is a presumed hypersensitivity response in incompletely immunized patients. | 1979 | 441371 |
| contributions to the diagnosis of subacute sclerosing panencephalitis in children. | 1979 | 441662 | |
| temperature-dependent expression of measles virus structural proteins in persistently infected cells. | 1979 | 442534 | |
| epidemic measles in young adults. clinical, epidemiologic, and serologic studies. | an outbreak of measles at the university of california at los angeles provided the opportunity to study clinical, epidemiologic, and serologic characteristics of the disease in young adults in the present vaccine era. of the 34 cases studied, 18 occurred in persons who thought they were immune. fifteen of 19 seronegative students vaccinated during the epidemic responded with a secondary (igg) antibody response. antibody prevalence studies indicated that 91% of the student population had measles ... | 1979 | 443682 |
| atypical measles in adolescents and young adults. | seven patients, aged 12 to 19 years, had atypical measles. prodromal symptoms of fever, malaise, myalgia, headache, nausea, and vomiting were commonly followed by coryza, sore throat, conjunctivitis, photophobia, nonproductive cough, and pleuritic pain. the characteristic rash was erythematous, maculopapular, and progressed frequently to vesicular, petechial, or purpuric lesions. it initially involved palms and soles with subsequent spread to proximal extremities and the trunk, sparing the face. ... | 1979 | 443683 |
| measles and rubella virus antibodies in patients with multiple sclerosis. a longitudinal study of serum and csf specimens by radioimmunoassay. | a longitudinal study on rubella, measles, and respiratory syncytial virus antibodies in serial serum and csf specimens from 20 multiple sclerosis (ms) patients was performed, using solid-phase radioimmunoassay. albumin and immunoglobulin g (igg) levels were also measured to check the integrity of the blood-brain barrier and the intrathecal igg production. all the patients had local igg production in their cna. a local antibody production against one or more of the viruses studied was evident in ... | 1979 | 444095 |
| subacute sclerosing panencephalitis during pregnancy. a surviving normal infant. | a normal infant was born to a 15-year-old girl who developed subacute sclerosing panencephalitis in the fifth month of pregnancy. the serum measles antibody titers of the infant gradually declined during the first year of life. the child, now age 3, has no neurological abnormalities. | 1979 | 444101 |
| potentiation of experimental allergic encephalomyelitis in hamsters with persistent encephalitis due to measles virus. | to clarify mechanisms underlying acute disseminated encephalomyelitis (ade) in patients with infection due to measles or other viruses, a new animal model was devised. adult hamsters that had clinically recovered from acute encephalitis induced by prior intracerebral injection of the hbs strain of measles virus were challenged with neuroantigen plus adjuvant. such hamsters, which had a high likelihood of carrying persistent hbs measles virus in the central nervous system (cns), exhibited a signi ... | 1979 | 448185 |
| additional evidence against measles vaccine administration to infants less than 12 months of age: altered immune response following active/passive immunization. | quantitative serologic responses following the inoculation of infants less than one year of age with live, further-attenuated measles virus vaccine were compared to those of infants and children inoculated after one year of age. active/passive immunization resulted in reduced antibody formation in some infants especially those less than 9 months of age. thirty-seven infants identified as "vaccine failures" following their initial inoculation at less than one year of age were revaccinated after o ... | 1979 | 448525 |
| characterization of measles virus-specific proteins synthesized in vivo and in vitro from acutely and persistently infected cells. | measles virus protein synthesis has been analyzed in acutely and persistently infected cells. to assess the role of measles in subacute sclerosing panencephalitis (sspe), measles viral proteins synthesized in vivo or in vitro were tested for reactivity with serum from a guinea pig(s) immunized with measles virus and sera from patients with sspe. guinea pig antimeasles virus serum immunoprecipitates the viral polypeptides of 78,000 molecular weight (glycosylated [g]), 70,000 molecular weight (pho ... | 1979 | 448796 |
| antiviral antibody reacting on the plasma membrane alters measles virus expression inside the cell. | 1979 | 450095 | |
| viral pathogenesis and virulence. | 1979 | 450136 | |
| alterations of the thymus and peripheral lymphoid tissues in fatal measles. a review of 14 autopsy cases. | as a result of re-examining 14 autopsy cases of fatal measles, neither aplastic nor hypoplastic thymuses were found even in a case with giant cell pneumonia, but there were degenerative and/or necrotic changes with giant cells mostly in the thymus and less in the peripheral lymphoid organs such as spleen, lymph nodes, peyer's patches and tonsils. this damage of the lymphoid system was associated with the occurrence of complications, particularly of giant cell pneumonia and encephalitis. the lymp ... | 1979 | 452905 |
| serological survey of measles virus infection in children in pondicherry area. | 1979 | 457205 | |
| variable infection of vero cells and homologous interference after co-cultivation with hela cells with persistent defective infection by edmonston measles virus. | the hela subline k11a-hg-1 (line of hela cells persistently infected with edomonston measles virus but containing little or no transmissible infectious virus) was co-cultivated with vero cells. focal syncytia were formed containing measles antigen and accumulations of nucleocapsid-like structures with no detectable production of transmissible infectious virus or positive hemadsorption. the infection aborted between 2 and 3 weeks after preparation of co-cultures. upon subculture of co-cultures, o ... | 1979 | 457258 |
| immunoglobulin g from subacute sclerosing panencephalitis brain as an immunological reagent. | proteins were extracted at ph 2.5 from carefully washed brain homogenates of patients with subacute sclerosing panencephalitis. immunoglobulin g was isolated from the extracts by gel filtration and immunoadsorbent chromatography and was 125i radioiodinated. the labeled immunoglobulin g was reacted with purified measles virus antigens by crossed immunoelectrophoresis and utilized to identify antigens in measles-infected cell cultures and hamster brain tissue subjected to treatment corresponding t ... | 1979 | 457270 |
| classification of peste des petits ruminants virus as the fourth member of the genus morbillivirus. | peste des petits ruminants (ppr) is a virus disease of sheep and goats in west africa. when first described, the virus was considered a variant of rinderpest virus. the biological and physicochemical characteristics of the virus indicate that it is closely related to measles, rinderpest and canine distemper viruses. these three viruses form the genus morbillivirus of the paramyxoviridae. ppr virus is sufficiently distinct from these 3 viruses to justify considering it as the fourth member of the ... | 1979 | 457363 |
| a study of the measles virus-induced proteins incorporated into the cell membrane. | the polypeptide composition of a measles virus isolate from a case of subacute sclerosing panencephalitis, the halle strain, and the distribution of these polypeptides in the cell membrane have been investigated. in purified virus preparations, four major polypeptides were identified with molecular weights corresponding to 80k, 62k, 42k and 37k daltons. a minor band was found at 69k and several others with molecular weights +/- 100k. by specifically labeling the proteins exposed at the surface o ... | 1979 | 457364 |
| multiple sclerosis: etiology and epidemiology. | multiple sclerosis (ms) is a demyelinating, auto-immune disease which affect the central nervous system. the research seems to implicate a small or incomplete slow-growing virus as the causative agent. the measles virus has been suspected because of high titers of measles antibodies in ms patients' serum and cerebrospinal fluid. an immunological deficiency in ms patients may be linked to genetic factors such as hl-a tissue types and histocompatibility antigens. genetics and socioeconomic conditi ... | 1979 | 458098 |
| immune response in subacute sclerosing panencephalitis: reduced antibody response to the matrix protein of measles virus. | immune precipitation was used to study the humoral immune response of patients with subacute sclerosing panencephalitis (sspe). patients with sspe have a progressive infection of the cns by measles or a measles variant despite high serum antibody levels to measles virus as measured by standard serologic techniques. however, when the antibody response to individual measles virus proteins was measured, we found a striking reduction in the ability of sera from patients with sspe to precipitate the ... | 1979 | 458157 |
| temperature sensitivity of subacute sclerosing panencephalitis virus and its ability to establish persistent infection. | 1979 | 461471 | |
| measles virus specific precipitins in sera from patients with chronic active hepatitis. | measles virus specific antibodies in sera from 29 patients with chronic active hepatitis have been examined using standard serological tests and immunoelectrophoretic techniques. significantly raised cf antibody titres against measles virus antigen were demonstrated in 50% of the sera. the major immunoprecipitate obtained by immunoelectrophoresis was shown to contain aggregates of measles virus nucleocapsids. antibodies against the haemagglutinin antigen of the virus envelope were also raised an ... | 1979 | 462137 |
| late-onset malignant astrocytoma in a case of multiple sclerosis. clinical, neuropathological, virological, and tissue culture studies. | an unusual case of concurrent ms and anaplastic astrocytoma is presented. ms was diagnosed in a female patient at the age of 22 years. a left side thalamotomy was performed for relief of severe intention tremor at age 28 and at age 32 she received immunosuppressive therapy for 1 year. at the age of 36 after a severe exacerbation of her symptoms a left side fronto-temporal tumor was diagnosed and a subtotal neurosurgical extirpation was performed. histopathologically, the tumor was an anaplastic ... | 1979 | 463500 |
| enhancement and suppression by actinomycin d of a vero cell nontransmissible measles infection. | the effect of low doses of actinomycin d on vero cell nontransmissible measles infection produced after cocultivation with a hela subline with persistent defective infection by edmonston measles virus was examined by pretreatment of vero cells with the drug and treatment at 1, 4, and 7 days after vero cell infection. pretreatment enhanced focal formation of viral immunofluorescent vero cell syncytia but did not induce synthesis of detectable amounts od cocultures suppressed syncytial formation, ... | 1979 | 468384 |
| [etiological factors and disturbances of local immunity as the origin of recurrent respiratory infections. role of viruses]. | 1979 | 471764 | |
| demonstration of anti-rubella antibody-secreting cells in rheumatoid arthritis patients. | in the present study we describe a plaque-forming cell assay using erythrocytes coated with viral antigen, which detected anti-viral antibody-secreting cells against various viral antigens. these anti-viral antibody-secreting cell were studied in normal individuals with known viral infections and in rheumatoid arthritis patients. rubella anti-viral antibody-secreting cells were present after induction in the peripheral blood of eight out of ten patients. no plaques were seen before induction. sy ... | 1979 | 472665 |
| lysis of measles virus-infected cells by the purified cytolytic alternative complement pathway and antibody. | the dependence of antibody-and-complement-mediated lysis of virus-infected cells on the alternative pathway was examined utilizing the isolated cytolytic alternative pathway--a system consisting of the six purified proteins of the alternative pathway of activation (c3, factors b and d, beta 1h, c3b inactivator and properdin), and the five proteins of the membrane attack pathway (c5--9) of complement. hela cells acutely infected with measles virus were lysed by anti-viral igg and the isolated cyt ... | 1979 | 479760 |
| role of virus variants and cells in maintenance of persistent infection by measles virus. | hamster embryo fibroblasts persistently infected with a derivative of the schwarz vaccine strain of measles virus spontaneously released virus particles with an average buoyant density considerably lower than that of the parental virus. the released virus contained all of the measles virus structural proteins and interfered with replication of standard virus. all of the virus structural proteins were associated with a membrane-free cytoplasmic extract from the persistently infected cells. membra ... | 1979 | 480462 |
| the binding of protein a of immunoglobulin g and of fab and fc fragments. | results are presented to show that protein a (pa) may fix to the fab region of igg outside the antigen binding site. thus, pa-reactive fab fragments were isolated both from specific anti-egg albumin and specific anti-measles virus antibodies. a probable significance of this fab reactivity in the precipitation reaction between igg and pa is discussed. reactive igg from human, guinea pig, rabbit, and porcine normal sera all showed similar avidity towards pa. slight differences between igg subclass ... | 1979 | 484238 |
| lymphocyte-mediated cytotoxicity to measles virus in patients with multiple sclerosis. | 1979 | 487666 | |
| measles virus-specific igm antibodies and igm-class rheumatoid factor in serum and cerebrospinal fluid of subacute sclerosing panencephalitis patients. | 1979 | 487667 | |
| alternative complement pathway-mediated lysis of measles virus infected cells: induction by igg antibody bound to individual viral glycoproteins and comparative efficacy of f(ab')2 and fab' fragments. | 1979 | 489977 | |
| isolation and characterisation of a defective measles virus from a subacute sclerosing panencephalitis patient. | a cytopathic measles virus was isolated from a brain biopsy of a subacute sclerosing panencephalitis (sspe) patient. the agent could be transferred to vero cells by cocultivation, but the infectivity always remained cell-associated -ie, a defective virus infection. the cell-associated nature of the virus was retained through 25 passages in vero cells. intracerebral inoculation of hamsters (2-6 days old) with the cocultured vero cells gave rise to 100% mortality in 5-7 days. the virus retained it ... | 1979 | 490144 |
| hla antigens and the response to influenza a virus. | an attempt was made to confirm a previously reported association between hla type b16 and resistance to infection with live attenuated influenza a virus vaccine. no differences were found either in the ability of influenza virus to attach to fractionated white blood cells from hlb b16 subjects compared to cells from subjects of other hla types, nor in the incidence of antibodies to three consecutive epidemic strains of influenza in sera from b16 subjects and control subjects. the association bet ... | 1979 | 494590 |
| antibodies to the acetylcholine receptor in myasthenic dogs. | antibodies to the achr and anti-striational antibodies have been detected in dogs suffering from myasthenia gravis. the detection of these antibodies adds to the known similarities between the human and canine disease. this animal model will facilitate investigation of agents involved in the induction of spontaneous myasthenia gravis. | 1979 | 500127 |
| cytotoxic antibody to cells infected with measles virus in serum and cerebrospinal fluid of multiple sclerosis and control patients. | sera and cerebrospinal fluids (csfs) from 66 patients selected from a larger sample of multiple sclerosis (ms) and control patients were studied for presence of complement-dependent cytotoxic (ct) antibody against baby hamster kidney cells infected with measles virus, strain lec. the ms group contained 26 patients with clinically definite disease and 7 with probable ms. seventeen of the 33 patients selected from the ms group had hemagglutination-inhibiting (hi) antibody to measles virus in their ... | 1979 | 500802 |
| effect of undiluted passage on the polypeptides of measles virus. | measles virus induces a large polypeptide (l; mol. wt. 180 k), a large glycopolypeptide (h; mol. wt. 80 k), a nucleocapsid associated polypeptide (p; mol. wt. 70 k), a nucleocapsid polypeptide (n; mol. wt. 60 k), a second glycopolypeptide (f0; mol. wt. 60 k), a matrix or membrane polypeptide (m; mol. wt. 37 k) and a small polypeptide (s; mol. wt. 15 k). the second glycopolypeptide (f0) appears to be cleaved in purified measles virus. defective interfering particles accumulate during passage of m ... | 1979 | 501334 |
| cell-free synthesis of measles virus proteins. | polyadenylated mrna extracted from cytoplasm of measles virus-infected vero cells was translated in a cell-free system. three of the polypeptides obtained corresponded to nucleocapsid protein, phosphoprotein, and membrane protein of measles virions. a fourth polypeptide, present in measles virus-infected cells, could be generated by addition of vero cytoplasmic extract and was identified as a cleavage product of the nucleocapsid protein. | 1979 | 501804 |
| [effect in vitro passages on biological properties of attenuated strains of measles virus. ii. immunogenic activity]. | 1979 | 502644 | |
| [chronic measles neuroinfection in syrian hamsters]. | measles neuroinfection was studied in 3-week syrian hamsters inoculated intracerebrally with the neurovirulent edmonston-42 strain of measles virus. the infectious virus was shown to be recoverable from the animals' brains both early after infection (up to 16 days) and at later intervals (28--63 days). at the same intervals (up to 69 days), measles antigen was demonstrated in brain impressions. all the animals under study had rna-containing inclusions in some cells, slight cellular infiltrates a ... | 1979 | 506206 |
| subacute sclerosing panencephalitis after drug-induced immunosuppression. | a girl developed subacute sclerosing panencephalitis (sspe). eight years earlier she had had measles infection contracted shortly after cytotoxic treatment and radiotherapy for a spinal neuroblastoma. the case illustrates that typical sspe, like immunosuppressive measles encephalopathy, can arise after drug-induced immunosuppression, and supports the view that these diseases probably represent opposite ends of a spectrum induced by measles virus infection in an individual with some form of immun ... | 1979 | 507919 |
| [experimental model for studies on viral encephalitis (author's transl)]. | 1979 | 507949 | |
| measles virus-specified polypeptide synthesis in two persistently infected hela cell lines. | measles virus-directed protein synthesis was examined in two hela cell lines (k11 and k11a) that are persistently infected with wild-type measles virus. four viral proteins (h, hemagglutination protein; p, nucleocapsid-associated protein; np, the major nucleocapsid protein; and m, the matrix protein) were readily detected in both cell lines by immune precipitation of [(35)s]methionine-labeled cell extracts followed by sodium dodecyl sulfate-polyacrylamide gel electrophoresis. when analyzed by so ... | 1979 | 513191 |
| efficient propagation of measles virus in suspension cultures. | suspension cultures of a human prostate cell line (ma160) supported abundant growth of the edmonston strain of measles virus. the virus yields obtained with these suspension cultures (150 to 800 pfu/cell) were at least 20- to 100-fold higher than those frequently reported in the literature. monolayer cultures of ma160 cells did not support a virus replication nearly as efficiently (progeny yield, 25 pfu/cell). | 1979 | 513197 |
| follow-up surveillance for antibody in human subjects following live attenuated measles, mumps, and rubella virus vaccines. | 1979 | 515009 | |
| evidence for lack of synthesis of the m polypeptide of measles virus in brain cells in subacute sclerosing panencephalitis. | 1979 | 516455 | |
| growth of measles virus in continuous cell lines derived from the nervous tissues of human and rat. | growth of two measles virus strains, the tycsa and cam, was compared in three continuous cell lines derived from the nervous tissues, human neuroblastoma imr-32, human glioma 118mgc, and rat glioma c-6. the two human neural cells were shown to support the growth of both measles virus strains as efficiently as in the non-neural vero cells. different types of cytopathic effect (cpe) between the two virus strains were noticed in imr-32 cells; the cam strain induced strand-forming type cpe and the t ... | 1979 | 518297 |
| measles sero-immunity in rural non-vaccinated children of busoga district, uganda. | 1979 | 520246 | |
| neurological complications following measles vaccination. | in hamburg 18 cases of neurological complications following vaccination with live measles virus vaccine (including 2 cases of abortive encephalopathy) have been observed between 1971--1978. a causal connection was assumed in 14 cases, that means an incidence of 1 neurological complication per 2,500 vaccinees and an incidence of 1 abortive encephalopathy per 17,650 vaccinees. these results differ from studies of various countries which used the same vaccine strain (schwarz). clinical symptoms, ag ... | 1979 | 520673 |
| measles antibodies and histocompatibility types in multiple sclerosis. | measles antibody titres and hla antigens were determined in 71 white and 11 coloured multiple sclerosis (ms) patients and 71 white and 11 coloured age and sex-matched controls. measles antibody titres were determined by the hemagglutination inhibition test and hla antigens were determined serologically by a micro-lymphocytotoxicity test. measles antibody titres were significantly higher in ms than in control cases and this was true for both female and male patients. no association was observed b ... | 1979 | 521827 |
| modulation of the adherence of human lymphocytes to measles-infected cells by prostaglandin e1: a differential effect on lymphocyte subpopulations. | prostaglandins of the e series (pge) may serve as important regulators of human immune responsiveness. the present study was designed to examine the possibility that pge may effect human lymphocyte function by the modulation of surface receptors. the presence of surface binding sites on human lymphocytes for measles virus antigens was studied using a rosette adherence assay. we observed that the addition of pge1 increased the proportion of measles-infected cells (hela-kll) with adherent lymphocy ... | 1979 | 523674 |
| assay of interferon and viral antibodies in the cerebrospinal fluid in clinical neurology and psychiatry. | cerebrospinal fluids (csf) of 245 neurological and 194 psychiatric patients were tested for viral antibodies and interferon. complement dependent neutralizing antibodies to herpesvirus hominis 1 were found in the csf of patients with encephalitis (50.6%), meningitis (35.4%), lesions of peripheral nerves (36.9%), sclerosis multiplex (41.2%), schizophrenia (31.9%), senile dementia (51.4%), mental retardation (11.1%), ethylism (43.5%). neutralizing antibodies to tick-borne encephalitis virus were f ... | 1979 | 525159 |
| [psoriasis and measles (author's transl)]. | 1979 | 527060 | |
| sspe-biken: a naturally arising hemagglutination-defective mutant of measles virus. | biochemical and genetic methods have been used to investigate a defective variant of measles virus previously isolated from a patient with subacute sclerosing panencephalitis (sspe). since its isolation, this syncytiogenic strain (sspe-biken) has remained cell-associated; infected cells do not hemadsorb and do not release infectious virus. immune precipitation and polyacrylamide gel electrophoresis were used to study the synthesis of measles virion proteins in sspe-biken-infected cells. all of t ... | 1979 | 528985 |
| [eye manifestations of subacute sclerosing panencephalitis]. | a report is given on 10 children with subacute sclerosing panencephalitis (sspe) whose clinical illness began with visual or mental impairment. all patients showed typical clinical and neurologic features and various ophthalmological manifestations. the latter correspond to lesions generally dealt with in a number of reports and demonstrate for the individual case that ophthalmological manifestation can precede clinical manifestation. the ophthalmologist can give an important contribution to the ... | 1979 | 530551 |