Publications
| Title | Abstract | Year Filter | PMID(sorted ascending) Filter |
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| necrotic colitis in two cats - a description of the lesions. | the lesions in two cases of necrotic colitis in old cats are described. both had gross lesions of a necrotic, hemorrhagic colitis without gross lesions in the small intestine. histologically the lesions resembled those of feline panleukopenia virus infection, namely: necrosis and loss of crypt epithelium, dilation of crypts and lining of crypts by flattened epithelium, subsequent collapse of the lamina propria and hemorrhage from subepithelial capillaries. both grossly and histologically these l ... | 1982 | 17422154 |
| a serologic assessment of exposure to viral pathogens and leptospira in an urban raccoon (procyon lotor) population inhabiting a large zoological park. | in urban environments, raccoons (procyon lotor) may act as reservoirs for an array of pathogenic organisms, presenting spillover risks for human, domestic animal, and captive (zoo) animal populations. over 5 yr, 159 raccoons from a high-density raccoon population in st. louis, missouri (usa), were surveyed for exposure to canine distemper virus (cdv), canine adenovirus 1 (cav-1); feline parvovirus (fpv; =feline panleukopenia), and several serovars of leptospira interrogans. exposure to each of t ... | 2007 | 17469271 |
| evaluation of tongue as a complementary sample for the diagnosis of parvoviral infection in dogs and cats. | diagnosis of canine parvovirus type 2 and feline panleukopenia virus infection in dogs and cats may be hampered by the severity of enteric lesions, secondary bacterial overgrowth, and rapid onset of autolysis. in contrast to small intestine, tongue epithelium is less sensitive to postmortem changes. sections of tongue and small intestine from 11 dogs and 11 cats with a clinical history and gross and microscopic lesions compatible with canine and feline parvoviral infection were examined for parv ... | 2007 | 17609353 |
| concurrent infection of a cat with cowpox virus and feline parvovirus. | concurrent infection with cowpox and feline parvovirus was diagnosed in a 5-month-old male european short hair cat. microscopical examination of the facial skin, ears and foot pads revealed multifocal to coalescing, ulcerative to necrotizing dermatitis and panniculitis with ballooning epidermal degeneration and eosinophilic cytoplasmic inclusion bodies. immunohistochemistry, polymerase chain reaction testing and virus isolation confirmed infection with a strain of cowpox virus similar to that is ... | 2007 | 17645887 |
| evaluation of the association of bartonella species, feline herpesvirus 1, feline calicivirus, feline leukemia virus and feline immunodeficiency virus with chronic feline gingivostomatitis. | gingivostomatitis (gs) is a significant condition in cats because of oral discomfort and associated periodontal disease. several infectious agents have been associated with the presence of gs, but a causal relationship is unclear. the cats in this study were housed together, had a history of flea exposure, and were vaccinated with a modified live fvrcp product. there were nine cats with active gs and 36 unaffected cats at the time of sample collection. serum was tested for feline leukemia virus ... | 2008 | 17766156 |
| specific identification of feline panleukopenia virus and its rapid differentiation from canine parvoviruses using minor groove binder probes. | taking into account reports of the isolation of canine parvoviruses (cpvs) from faecal samples of cats, we developed a real-time pcr assay, based on minor groove binder (mgb) probe technology, for rapid discrimination between true feline panleukopenia viruses (fplvs) from cpvs. the assay takes advantage of a single nucleotide polymorphism at position 3753 of the viral genome (corresponding to residue 323 of the capsid vp2 protein) and of the ability of mgb probes to bind specifically only to per ... | 2008 | 17850892 |
| seroepizootiological survey for selected viral infections in captive asiatic lions (panthera leo persica) from western india. | infectious diseases have been responsible for large-scale declines in many endangered animals. disease outbreaks in small populations have probably led to the eventual extinction of such endangered animals in the wild. the endangered asiatic lion (panthera leo persica) population may also face such threats. this was evident from this study on captive asiatic lions from western india, which were sampled from december 1998 to march 1999. fifty-six asiatic lions, including 17 hybrid lions (afro-asi ... | 2007 | 17939348 |
| naturally occurring parvovirus-associated feline hypogranular cerebellar hypoplasia-- a comparison to experimentally-induced lesions using immunohistology. | three cases of feline cerebellar hypoplasia are presented. at the time of examination, the ages of the cats ranged from 2 months to 1 year. necropsy revealed cerebellar and pons hypoplasia. polymerase chain reaction for parvoviral deoxyribonucleic acid was positive in cerebellar tissue. cell-specific immunolabeling was used to characterize the lesions, which were characterized into 2 types. in type 1 lesions, the cortex was nearly agranular, with an extremely thin molecular layer; the purkinje c ... | 2007 | 18039896 |
| comparison of different in-house test systems to detect parvovirus in faeces of cats. | in-house tests for the identification of faecal parvovirus antigen are now available. the majority of these are licensed for canine parvovirus only; but anecdotal information suggests that they will detect feline panleukopenia virus (fpv) as well. this prospective study was designed to compare five commercially available test systems. in total, 200 faecal samples from randomly selected healthy cats (148) and cats with diarrhoea (52) were tested and compared with the results of examination by ele ... | 2008 | 18243743 |
| complete protection of cats against feline panleukopenia virus challenge by a recombinant canine adenovirus type 2 expressing vp2 from fpv. | feline panleukopenia virus (fpv) is an important infectious pathogen of all members of the family felidae. here, we describe construction of a replication-competent recombinant canine adenovirus type 2 (cav-2) expressing the vp2 protein of fpv (cav-2-vp2) by transfection of mdck cells with recombinant cav-2 genome carrying a vp2 expression cassette. ten 3-month-old cats were vaccinated with the recombinant virus with two boosters at 15-day intervals. all cats developed neutralizing antibodies of ... | 2008 | 18313810 |
| combined administration in a single injection of a feline multivalent modified live vaccine against fhv, fcv, and fplv together with a recombinant felv vaccine is both safe and efficacious for all four major feline viral pathogens. | nobivac tricat, a lyophilised trivalent modified live attenuated vaccine is routinely used to protect cats against three commonly diagnosed feline viral pathogens namely herpesvirus, calicivirus and panleukopenia virus. the recognition of feline leukaemia virus (felv) as an important viral pathogen has prompted the development of an efficacious liquid recombinant subunit felv vaccine (p45 envelope protein). lyophilised tricat vaccine was dissolved in the liquid felv vaccine and no detectable del ... | 2008 | 18448375 |
| parvovirus infection in domestic companion animals. | parvovirus infects a wide variety of species. the rapid evolution, environmental resistance, high dose of viral shedding, and interspecies transmission have made some strains of parvovirus infection difficult to control within domestic animal populations. some parvoviruses in companion animals, such as canine parvovirus (cpv) 1 and feline parvovirus, have demonstrated minimal evolution over time. in contrast, cpv 2 has shown wide adaptability with rapid evolution and frequent mutations. this art ... | 2008 | 18501282 |
| compatibility between a rabies vaccine and a combined vaccine against feline rhinotracheitis, fcv, fplv and felv, and chlamydophila felis. | 2008 | 18503070 | |
| effects of anesthesia and surgery on serologic responses to vaccination in kittens. | to determine the effects of anesthesia and surgery on serologic responses to vaccination in kittens. | 2008 | 18593319 |
| ocelots on barro colorado island are infected with feline immunodeficiency virus but not other common feline and canine viruses. | transmission of pathogens from domestic animals to wildlife populations (spill-over) has precipitated local wildlife extinctions in multiple geographic locations. identifying such events before they cause population declines requires differentiating spillover from endemic disease, a challenge complicated by a lack of baseline data from wildlife populations that are isolated from domestic animals. we tested sera collected from 12 ocelots (leopardus pardalis) native to barro colorado island, panam ... | 2008 | 18689668 |
| onset of immunity in kittens after vaccination with a non-adjuvanted vaccine against feline panleucopenia, feline calicivirus and feline herpesvirus. | the induction of a quick onset of immunity against feline parvovirus (fpv), feline herpesvirus (fhv) and feline calicivirus (fcv) is critical both in young kittens after the decline of maternal antibodies and in cats at high risk of exposure. the onset of immunity for the core components was evaluated in 8-9 week old specific pathogen free kittens by challenge 1 week after vaccination with a combined modified live (fpv, fhv) and inactivated (fcv) vaccine. the protection obtained 1 week after vac ... | 2009 | 18694649 |
| phylogenetic analysis reveals the emergence, evolution and dispersal of carnivore parvoviruses. | canine parvovirus (cpv), first recognized as an emerging virus of dogs in 1978, resulted from a successful cross-species transmission. cpv emerged from the endemic feline panleukopenia virus (fpv), or from a closely related parvovirus of another host. here we refine our current understanding of the evolution and population dynamics of fpv and cpv. by analysing nearly full-length viral sequences we show that the majority of substitutions distinguishing cpv from fpv are located in the capsid prote ... | 2008 | 18753238 |
| genetic analysis of feline panleukopenia viruses from cats with gastroenteritis. | thirty-nine parvovirus strains contained in faecal samples collected in italy (n=34) and uk (n=5) from cats with feline panleukopenia were characterized at the molecular level. all viruses were proven to be true feline panleukopenia virus (fplv) strains by a minor groove binder probe assay, which is able to discriminate between fplv and the closely related canine parvovirus type 2. by using sequence analysis of the vp2 gene, it was found that the fplv strains detected in italy and uk were highly ... | 2008 | 18753239 |
| within-host genetic diversity of endemic and emerging parvoviruses of dogs and cats. | viral emergence can result from the adaptation of endemic pathogens to new or altered host environments, a process that is strongly influenced by the underlying sequence diversity. to determine the extent and structure of intrahost genetic diversity in a recently emerged single-stranded dna virus, we analyzed viral population structures during natural infections of animals with canine parvovirus (cpv) or its ancestor, feline panleukopenia virus (fpv). we compared infections that occurred shortly ... | 2008 | 18768982 |
| feline panleukopenia virus, feline herpesvirus-1, and feline calicivirus antibody responses in seronegative specific pathogen-free cats after a single administration of two different modified live fvrcp vaccines. | two groups of feline panleukopenia virus (fpv), feline calicivirus (fcv), and feline herpesvirus-1 (fhv-1) seronegative cats (five cats per group) were administered one of two modified live feline viral rhinotracheitis, calicivirus, and panleukopenia virus (fvrcp) vaccines and the serological responses to each agent were followed over 28 days. while all cats developed detectable fpv and fcv antibody titers; only two cats developed detectable fhv-1 antibody titers using the criteria described by ... | 2009 | 18782676 |
| activation of p38 mapk by feline infectious peritonitis virus regulates pro-inflammatory cytokine production in primary blood-derived feline mononuclear cells. | feline infectious peritonitis (fip) is an invariably fatal disease of cats caused by systemic infection with a feline coronavirus (fcov) termed feline infectious peritonitis virus (fipv). the lethal pathology associated with fip (granulomatous inflammation and t-cell lymphopenia) is thought to be mediated by aberrant modulation of the immune system due to infection of cells such as monocytes and macrophages. overproduction of pro-inflammatory cytokines occurs in cats with fip, and has been sugge ... | 2009 | 19058829 |
| characterization of a continuous feline mammary epithelial cell line susceptible to feline epitheliotropic viruses. | mucosal epithelial cells are the primary targets for many common viral pathogens of cats. viral infection of epithelia can damage or disrupt the epithelial barrier that protects underlying tissues. in vitro cell culture systems are an effective means to study how viruses infect and disrupt epithelial barriers, however no true continuous or immortalized feline epithelial cell culture lines are available. a continuous cell culture of feline mammary epithelial cells (fmec ucd-04-2) that forms tight ... | 2009 | 19103225 |
| recombination between vaccine and field strains of canine parvovirus is revealed by isolation of virus in canine and feline cell cultures. | canine parvovirus type 2 (cpv) is a pathogen that causes severe hemorrhagic gastroenteritis with a high fatality rate in pups worldwide. since cpv emerged in the late 1970s, its origin has been explored with the conclusion that cpv originated from feline panleukopenia virus or a closely related virus. both high mutation rate and recombination are assumed to be key factors in the evolution of parvoviruses. here we provide evidence for natural recombination in cpv isolated from dogs in cell cultur ... | 2008 | 19122396 |
| parvovirus infection in a eurasian lynx (lynx lynx) and in a european wildcat (felis silvestris silvestris). | a eurasian lynx and a european wildcat from the same wildlife park were submitted for necropsy examination after sudden death and after death following a clinical history of lethargy, respectively. neither animal had been vaccinated against feline parvovirus (feline panleukopenia virus). feral domestic cats were widespread in the area of the wildlife park and a number of these animals that had been captured had recently died from parvovirus infection. gross and microscopical findings in the two ... | 2009 | 19135211 |
| feline parvovirus infection in an asian palm civet (paradoxurus hermaphroditus). | 2009 | 19218594 | |
| the swedish breeding cat: population description, infectious diseases and reproductive performance evaluated by a questionnaire. | the questionnaire based study gives a combined description of management, infectious diseases and reproductive performance in breeding catteries during 1 year. the mean number of cats per cattery was 6.1, and 25% of the breeders let some of their cats have free access to outdoors. breeders reported that infection with feline panleukopenia virus, feline immunodeficiency virus or feline leukaemia virus was uncommon, but 8% of the breeders had sold or had themselves owned a cat that died of feline ... | 2009 | 19254857 |
| evidence for recombination between feline panleukopenia virus and canine parvovirus type 2. | canine parvovirus type 2 (cpv) is a virulent pathogen that emerged in the late 1970s, probably originating from feline panleukopenia virus (fplv) or a closely related carnivore parvovirus belonging to the feline parvovirus (fpv) subspecies. in contrast to fplv, cpv has evolved rapidly since its emergence. the original antigenic type of cpv disappeared more than two decades ago and several new antigenic as well as genetic cpv variants have appeared and spread in the field. both high mutation rate ... | 2009 | 19420841 |
| feline panleukopenia. abcd guidelines on prevention and management. | overview: feline panleukopenia virus (fpv) infects all felids as well as raccoons, mink and foxes. this pathogen may survive in the environment for several months and is highly resistant to some disinfectants. infection: transmission occurs via the faecal-oral route. indirect contact is the most common route of infection, and fpv may be carried by fomites (shoes, clothing), which means indoor cats are also at risk. intrauterine virus transmission and infection of neonates can occur. disease sign ... | 2009 | 19481033 |
| seroprevalence of viral infections in domestic cats in costa rica. | a cross-sectional survey of a convenient sample of domestic cats from costa rica's greater metropolitan area was carried out to determine the prevalence of antibodies against feline herpesvirus type 1 (fhv-1), feline parvovirus (fpv), feline immunodeficiency virus (fiv) and antigens of feline leukemia virus (felv). blood samples were collected from at least 96 cats from june 1998 to december 2001; data related to the individual cats and household variables were obtained using a questionnaire. an ... | 2009 | 19498296 |
| fatal infection with feline panleukopenia virus in two captive wild carnivores (panthera tigris and panthera leo). | two cases of fatal infection caused by parvovirus in a white tiger (panthera tigris) and an african lion (panthera leo) at the lisbon zoo (portugal) are described. gross findings at necropsy were catharral enteritis in the tiger and severe hemorrhagic enteritis in the lion. histopathologic examination revealed, in both animals, intestinal crypt necrosis and lymphocyte depletion in the germinal centers of the mesenteric lymph nodes. bacteriologic examination was negative for common bacterial path ... | 2009 | 19569486 |
| [preparation of the vaccine with inactivated feline panleukopenia virus isolated from tiger and the preliminary application]. | to prepare a vaccine with inactivated feline panleukopenia virus (fpv) isolated from siberian tigers and to evaluate its immunological effect. | 2009 | 19637573 |
| early steps in cell infection by parvoviruses: host-specific differences in cell receptor binding but similar endosomal trafficking. | canine parvovirus (cpv) and feline panleukopenia virus (fpv) are closely related parvoviruses that differ in their host ranges for cats and dogs. both viruses bind their host transferrin receptor (tfr), enter cells by clathrin-mediated endocytosis, and traffic with that receptor through endosomal pathways. infection by these viruses appears to be inefficient and slow, with low numbers of virions infecting the cell after a number of hours. species-specific binding to tfr controls viral host range ... | 2009 | 19656887 |
| isolation and characterization of feline panleukopenia virus from a diarrheic monkey. | a feline panleukopenia virus (fpv) mutant, monkey/bj-22/2008/chn, was isolated from intestinal contents of a diarrheic monkey in beijing, china. the virus was identified by morphology and physicochemical characteristics, and specific fragments were obtained by pcr using consensus primers of parvovirus and specific primers of fpv. sequence of the full-length vp2 gene of the isolated fpv was determined and analyzed by comparison with reference fpv and canine parvovirus (cpv) isolates, showing high ... | 2010 | 20044220 |
| antibodies against crandell rees feline kidney (crfk) cell line antigens, alpha-enolase, and annexin a2 in vaccinated and crfk hyperinoculated cats. | cats inoculated with feline herpesvirus 1, calicivirus, and panleukopenia (fvrcp) vaccines grown on the crandell rees feline kidney (crfk) cell line have been shown to develop anti-crfk antibodies. the identities of common crfk antigens are unknown. | 2010 | 20136712 |
| binding site on the transferrin receptor for the parvovirus capsid and effects of altered affinity on cell uptake and infection. | canine parvovirus (cpv) and its relative feline panleukopenia virus (fpv) bind the transferrin receptor type 1 (tfr) to infect their host cells but show differences in the interactions with the feline and canine tfrs that determine viral host range and tissue tropism. we changed apical and protease-like domain residues by introducing point mutations and adding or removing glycosylation signals, and we then examined the interactions of those mutant tfrs with the capsids. most substitutions had li ... | 2010 | 20200243 |
| detection of feline panleukopenia virus using a commercial elisa for canine parvovirus. | feline panleukopenia virus (fpv) is a significant pathogen of cats. rapid virus detection is critical for treatment and management, especially in populations in which spread may occur. this study investigated the ability of the snap canine parvovirus antigen test kit (snap parvo, idexx laboratories) to detect fpv with confirmation of viral identity by polymerase chain reaction (pcr) assay and genetic sequencing on fecal samples (n = 97) from cats with suspected fpv infection. fifty-five samples ... | 2009 | 20425728 |
| quantitation of virus using laser-based scanning of near-infrared fluorophores replaces manual plate reading in a virus titration assay. | a method was developed for quantitation of a virus titration assay for minimally cytopathic and noncytopathic viruses that utilizes laser-based scanning of near-infrared (nir) fluorophores. this automated method bypasses the need for manual plate reading thus eliminating human bias and error. the image data is translated by li-cor's odyssey software into numerical data which is used directly in the virus titer calculations. | 2010 | 20438762 |
| does a feline leukemia virus infection pave the way for bartonella henselae infection in cats? | domestic cats serve as the reservoir hosts of bartonella henselae and may develop mild clinical symptoms or none after experimental infection. in humans, b. henselae infection can result in self-limiting cat scratch disease. however, immunocompromised patients may suffer from more-severe courses of infection or may even develop the potentially lethal disease bacillary angiomatosis. it was reasoned that cats with immunocompromising viral infections may react similarly to b. henselae infection. th ... | 2010 | 20610682 |
| phylogenetic analysis of feline panleukopenia virus (fplv) strains in korean cats. | sixteen korean feline panleukopenia virus (fplv) strains were compared with 48 non-korean strains and two vaccine strains to conduct phylogenetic analysis of the fplvs currently circulating among cats in korea. most of the residues that discriminate between fplvs and canine parvoviruses (cpv-2, -2a, -2b, and -2c), including 80-lys, 93-lys, 103-val, 323-asp, 564-asn, and 568-ala, were conserved in the korean flpvs; however, exceptions were observed in two strains, namely k50/08 (80-gln) and v142 ... | 2011 | 20627272 |
| genetic variability and viral seroconversion in an outcrossing vertebrate population. | inverse correlations between genetic variability and parasitism are important concerns for conservation biologists. we examined correlations between neutral genetic variability and the presence of antibodies to canine distemper virus (cdv) and feline parvovirus (fpv) in a free-ranging population of raccoons. over 3 years there was a strong relationship between age and seroprevalence rates. most young animals were seronegative to cdv and fpv, but the oldest age class was greater than 80 per cent ... | 2011 | 20667873 |
| prognostic factors in cats with feline panleukopenia. | feline panleukopenia is a highly contagious and often lethal disease. | 2010 | 21039863 |
| successive deaths of a captive snow leopard (uncia uncia) and a serval (leptailurus serval) by infection with feline panleukopenia virus at sapporo maruyama zoo. | feline parvoviruses were isolated from frozen samples of intestines taken from a snow leopard (uncia uncia) and a serval (leptailurus serval) that died successively at sapporo maruyama zoo in hokkaido, japan. isolates possessed an antigenic epitope for both the feline panleukopenia virus (fplv) and mink enteritis virus, identified with a hemagglutination inhibition test. sequencing analyses of the vp2 region of the isolates revealed that the two isolates were identical and of the fplv-type. thes ... | 2010 | 21116104 |
| genetic complexity and multiple infections with more parvovirus species in naturally infected cats. | abstract: parvoviruses of carnivores include three closely related autonomous parvoviruses: canine parvovirus (cpv), feline panleukopenia virus (fpv) and mink enteritis virus (mev). these viruses cause a variety of serious diseases, especially in young patients, since they have a remarkable predilection for replication in rapidly dividing cells. fpv is not the only parvovirus species which infects cats; in addition to mev, the new variants of canine parvovirus, cpv-2a, 2b and 2c have also penetr ... | 2011 | 21366901 |
| results of molecular diagnostic assays targeting feline herpesvirus-1 and feline calicivirus in adult cats administered modified live vaccines. | in this pilot study, 12 adult, gang-housed cats that were known to be previously exposed (n=12) to feline herpesvirus-1 (fhv-1) and/or vaccinated against (n=2) feline calicivirus (fcv) and fhv-1 were randomly assigned to one of two groups of six cats each. nasal and pharyngeal samples were collected from each cat on days -7, -3, and 0 prior to vaccination and on days 3, 7, 10, 14, 17, 21, and 28 after vaccination with an fhv-1, fcv, and panleukopenia (fvrcp) vaccine developed for intranasal (six ... | 2011 | 21439879 |
| when cats' ways of life interact with their viruses: a study in 15 natural populations of owned and unowned cats (felis silvestris catus). | in natural populations, virus circulation is influenced by host behavior and physiological characteristics. cat populations exhibit a great variability in social and spatial structure, the existence of different ways of life within a same population may also result in different epidemiological patterns. to test this hypothesis, we used a logistic regression to analyze the risk factors of feline immunodeficiency virus (fiv), feline herpes virus (fhv), feline calicivirus (fcv), and feline parvovir ... | 2011 | 21705099 |
| detection of protective antibody titers against feline panleukopenia virus, feline herpesvirus-1, and feline calicivirus in shelter cats using a point-of-care elisa. | serum antibody titers are a useful measurement of protection against infection (feline panleukopenia virus [fpv]) or clinical disease (feline herpesvirus-1 [fhv] and feline calicivirus [fcv]), and their determination has been recommended as part of disease outbreak management in animal shelters. the objective of this study was to determine the sensitivity, specificity, and inter-observer and inter-assay agreement of two semi-quantitative point-of-care assays for the detection of protective antib ... | 2011 | 21885311 |
| mixed infection by feline astrovirus and feline panleukopenia virus in a domestic cat with gastroenteritis and panleukopenia. | astroviruses are important pathogens of human beings and animals. feline astroviruses have been identified by electron microscopy in the feces of either asymptomatic or symptomatic cats, and experimental infection with one isolate was shown to induce enteric clinical signs and virus excretion, thus suggesting a possible role as enteric pathogen. however, due to the lack of specific diagnostic assays, feline astroviruses are not included in the diagnostic algorithms of feline infectious diseases, ... | 2011 | 21908295 |
| [Origin and evolution of canine parvovirus--a review]. | Canine parvovirus (CPV-2), first recognized in 1978 as a new pathogen of dogs, was probably derived from a very closely related virus in cats, feline panleukopaenia virus (FPLV) or a closely related carnivore parvovirus (FPLV-like virus). CPV-2 is responsible for either myocarditis or fatal gastroenteritis in pups with high morbidity and mortality. Shortly after its emergence, CPV-2 has become endemic in the global dog population. The original CPV-2 continued to evolve, and was subsequently repl ... | 2011 | 22043787 |
| the role of evolutionary intermediates in the host adaptation of canine parvovirus. | the adaptation of viruses to new hosts is a poorly understood process likely involving a variety of viral structures and functions that allow efficient replication and spread. canine parvovirus (cpv) emerged in the late 1970s as a host-range variant of a virus related to feline panleukopenia virus (fpv). within a few years of its emergence in dogs, there was a worldwide replacement of the initial virus strain (cpv type 2) by a variant (cpv type 2a) characterized by four amino acid differences in ... | 2011 | 22114336 |
| [Feline panleukopenia - different course of disease in cats younger versus older than 6 months of age?]. | Objective: The aim of this study was to evaluate differences between young cats (< 6 months) and adult cats (= 6 months) with feline panleukopenia with respect to clinical signs, laboratory abnormalities, environmental conditions, vaccination status, and outcome. Material and methods: Medical records of 244 cats diagnosed with panleukopenia between 1990 and 2007 at the Clinic of Small Animal Medicine, Ludwig-Maximilians University of Munich, Germany, were evaluated retrospectively. Cats that ... | 2011 | 22143661 |
| characterization of the partial vp2 gene region of canine parvoviruses in domestic cats from turkey. | canine parvoviruses (cpvs) is a category comprising three closely related viruses, cpv, feline panleukopenia virus (fplv), and mink enteritis virus, all of which cause serious diseases, especially in young cats. in this study, molecular detection and genetic analysis of a partial vp2 gene region of cpvs from domestic cats living in turkey between 2006 and 2010 was performed by pcr amplification and sequence analysis. the results indicated that cpv-2a, cpv-2c, and fplv were circulating in vaccina ... | 2011 | 22207487 |
| canine parvovirus in asymptomatic feline carriers. | canine parvovirus (cpv) and feline panleukopaenia virus (fplv) are two closely related viruses, which are known to cause severe disease in younger unvaccinated animals. as well as causing disease in their respective hosts, cpv has recently acquired the feline host range, allowing it to infect both cats and dogs. as well as causing disease in dogs, there is evidence that under some circumstances cpv may also cause disease in cats. this study has investigated the prevalence of parvoviruses in the ... | 2011 | 22257775 |
| effects of maternally-derived antibodies on serologic responses to vaccination in kittens. | the optimal vaccination protocol to induce immunity in kittens with maternal antibodies is unknown. the objective of this study was to determine the effects of maternally-derived antibody (mda) on serologic responses to vaccination in kittens. vaccination with a modified live virus (mlv) product was more effective than an inactivated (ia) product at inducing protective antibody titers (pat) against feline panleukopenia virus (fpv). ia vaccination against feline herpesvirus-1 (fhv) and feline cal ... | 2012 | 22314087 |
| feline panleukopenia virus, feline herpesvirus-1 and feline calicivirus antibody responses in seronegative specific pathogen-free kittens after parenteral administration of an inactivated fvrcp vaccine or a modified live fvrcp vaccine. | two groups of feline panleukopenia (fpv), feline calicivirus (fcv) and feline herpesvirus 1 (fhv-1) seronegative kittens (six cats per group) were administered one of two feline viral rhinotracheitis, calcivirus and panleukopenia (fvrcp) vaccines subcutaneously (one inactivated and one modified live) and the serological responses to each agent were followed over 49 days (days 0, 2, 5, 7, 10, 14, 21, 28, 35, 42, 49). while the kittens administered the modified live fpv vaccine were more likely to ... | 2012 | 22314095 |
| typing of canine parvovirus isolates using mini-sequencing based single nucleotide polymorphism analysis. | the antigenic types of canine parvovirus (cpv) are defined based on differences in the amino acids of the major capsid protein vp2. type specificity is conferred by a limited number of amino acid changes and in particular by few nucleotide substitutions. pcr based methods are not particularly suitable for typing circulating variants which differ in a few specific nucleotide substitutions. assays for determining snps can detect efficiently nucleotide substitutions and can thus be adapted to ident ... | 2012 | 22374103 |
| identification of parvovirus in the bone marrow of eight cats. | to determine if canine parvovirus (cpv) or feline panleucopenia virus (fpv) genomic sequences are present in adult feline bone marrow samples. | 2012 | 22443328 |
| in vitro assessment of the feline cell-mediated immune response against feline panleukopeniavirus, calicivirus and felid herpesvirus 1 using 5-bromo-2'-deoxyuridine labeling. | in this study an in vitro assay was optimized to detect feline proliferating lymphocytes as an assessment for the cell-mediated immune response. for this purpose, 5-bromo-2'-deoxyuridine (brdu) labeling was chosen because of its sensitivity and the possibility of further characterization of proliferating cells. the assay was optimized by selecting the best batch and concentration of fetal bovine serum, β-mercaptoethanol concentration, cell density, brdu incubation time and antigen presenting cel ... | 2012 | 22460172 |
| vaccination against feline panleukopenia: implications from a field study in kittens. | feline panleukopenia (fpl) is a serious disease of cats that can be prevented by vaccination. kittens are routinely vaccinated repeatedly during their first months of life. by this time maternally derived antibodies (mda) can interfere with vaccination and inhibit the development of active immunity. the efficacy of primary vaccination under field conditions was questioned by frequent reports to the paul-ehrlich-institut on outbreaks of fpl in vaccinated breeding catteries. we therefore initiated ... | 2012 | 22613093 |
| ultrasonographic diagnosis of a fibrinonecrotic colonic cast in a kitten with feline panleukopenia virus. | ultrasonography of a cat with diarrhoea and vomiting revealed a multi-layered, discrete linear structure within the large intestine with retention of the intestinal layers which could potentially be confused with an intestinal intussusception. the structure was ultimately expelled from the large intestine during defecation, and confirmed as a fibrinonecrotic cast. the origin of the fibrinonecrotic cast was assumed to be an intestinal pseudo-membrane formed in enteritis caused by immune suppressi ... | 2012 | 22690914 |
| antibody response to vaccines for rhinotracheitis, caliciviral disease, panleukopenia, feline leukemia, and rabies in tigers (panthera tigris) and lions (panthera leo). | this article presents the results of a study of captive tigers (panthera tigris) and lions (panthera leo) vaccinated with a recombinant vaccine against feline leukemia virus; an inactivated adjuvanted vaccine against rabies virus; and a multivalent modified live vaccine against feline herpesvirus, calicivirus, and panleukopenia virus. the aim of the study was to assess the immune response and safety of the vaccines and to compare the effects of the administration of single (1 ml) and double (2 m ... | 2012 | 22779227 |
| enteropathogens identified in cats entering a florida animal shelter with normal feces or diarrhea. | to determine the frequency of enteropathogens in cats entering an animal shelter with normal feces or diarrhea. | 2012 | 22812469 |
| exposure to selected pathogens in to selected pathogens in geoffroy's cats and domestic carnivores from central argentina. | wild carnivores share a high percentage of parasites and viruses with closely related domestic carnivores. because of increased overlap and potential contact with domestic species, we conducted a retrospective serosurvey for 11 common carnivore pathogens in 40 geoffroy's cats (leopardus geoffroyi) sampled between 2000 and 2008 within or near two protected areas in central argentina (lihué calel national park, la pampa, and campos del tuyú national park, buenos aires), as well as five domestic ca ... | 2012 | 23060491 |
| prevalence of serum antibody titers against feline panleukopenia virus, feline herpesvirus 1, and feline calicivirus in cats entering a florida animal shelter. | to determine the proportion of cats entering a florida animal shelter with serum antibody titers against feline panleukopenia virus (fpv), feline herpesvirus 1 (fhv1), and feline calicivirus (fcv) and to identify factors associated with seropositivity. | 2012 | 23113524 |
| on-line capillary electrophoresis for enhanced detection sensitivity of feline panleukopenia virus. | a rapid on-line capillary electrophoresis (ce) method for highly sensitive detection of dna molecules with specific lengths was developed based on the combination of base stacking (bs) and programmed field strength gradients (pfsg). the bs method has been performed for on-column concentration to improve detection sensitivity without any modification of the ce system. pfsg increased the electrophoretic velocity of dna molecules, which effectively decreased analysis time. using the bs and pfsg com ... | 2012 | 23153639 |
| expression of transferrin receptor 1, proliferating cell nuclear antigen, p27(kip1) and calbindin in the fetal and neonatal feline cerebellar cortex. | cerebellar cortices from feline fetuses with estimated gestational ages of 40-66days and from kittens aged 2days to 2months, all negative for feline panleukopenia virus (fpv) infection, were analysed for expression of the transferrin receptor 1 (trfr1), proliferating cell nuclear antigen (pcna), p27(kip1) and calbindin. trfr1, the receptor used by fpv to enter target cells, was expressed in capillary endothelial cells in the cerebellum at all fetal stages investigated and in purkinje cells of a ... | 2013 | 23159675 |
| identification of feline panleukopenia virus proteins expressed in purkinje cell nuclei of cats with cerebellar hypoplasia. | parvoviruses depend on initiation of host cell division for their replication. undefined parvoviral proteins have been detected in purkinje cells of the cerebellum after experimental feline panleukopenia virus (fpv) infection of neonatal kittens and in naturally occurring cases of feline cerebellar hypoplasia. in this study, a parvoviral protein in the nucleus of purkinje cells of kittens with cerebellar hypoplasia was shown by immunoprecipitation to be the fpv viral capsid protein vp2. in pcr-c ... | 2013 | 23159676 |
| frequent cross-species transmission of parvoviruses among diverse carnivore hosts. | although parvoviruses are commonly described in domestic carnivores, little is known about their biodiversity in nondomestic species. a phylogenetic analysis of vp2 gene sequences from puma, coyote, gray wolf, bobcat, raccoon, and striped skunk revealed two major groups related to either feline panleukopenia virus ("fpv-like") or canine parvovirus ("cpv-like"). cross-species transmission was commonplace, with multiple introductions into each host species but, with the exception of raccoons, rela ... | 2013 | 23221559 |
| fast parallel detection of feline panleukopenia virus dna by multi-channel microchip electrophoresis with programmed step electric field strength. | a multi-channel microchip electrophoresis using a programmed step electric field strength (psefs) method was investigated for fast parallel detection of feline panleukopenia virus (fpv) dna. an expanded laser beam, a 10× objective lens, and a charge-coupled device camera were used to simultaneously detect the separations in three parallel channels using laser-induced fluorescence detection. the parallel separations of a 100-bp dna ladder were demonstrated on the system using a sieving gel matrix ... | 2013 | 23233436 |
| canine and feline parvoviruses preferentially recognize the non-human cell surface sialic acid n-glycolylneuraminic acid. | feline panleukopenia virus (fpv) is a pathogen whose canine-adapted form (canine parvovirus (cpv)) emerged in 1978. these viruses infect by binding host transferrin receptor type-1 (tfr), but also hemagglutinate erythrocytes. we show that hemagglutination involves selective recognition of the non-human sialic acid n-glycolylneuraminic acid (neu5gc) but not n-acetylneuraminic acid (neu5ac), which differs by only one oxygen atom from neu5gc. overexpression of α2-6 sialyltransferase did not change ... | 2013 | 23497940 |
| snapshot of viral infections in wild carnivores reveals ubiquity of parvovirus and susceptibility of egyptian mongoose to feline panleukopenia virus. | the exposure of wild carnivores to viral pathogens, with emphasis on parvovirus (cpv/fplv), was assessed based on the molecular screening of tissue samples from 128 hunted or accidentally road-killed animals collected in portugal from 2008 to 2011, including egyptian mongoose (herpestes ichneumon, n = 99), red fox (vulpes vulpes, n = 19), stone marten (martes foina, n = 3), common genet (genetta genetta, n = 3) and eurasian badger (meles meles, n = 4). a high prevalence of parvovirus dna (63%) w ... | 2013 | 23527182 |
| feline panleukopenia virus: its interesting evolution and current problems in immunoprophylaxis against a serious pathogen. | vaccination of cats against feline panleukopenia virus (fpv) has been a routine part of feline medicine for the past 40 or more years, and many of the same vaccines that were first developed in the 1960s are still in routine use today. however, there has been significant evolution of the virus in the last 40 years, in particular the emergence of canine parvovirus (cpv) in dogs in the late 1970s, which was a host range variant of the fpv-like virus, and the world-wide spread of the cpv-derived vi ... | 2013 | 23561891 |
| co-infection with feline and canine parvovirus in a cat. | in this study we reported a case of co-infection with canine parvovirus (cpv) type 2a and feline panleukopenia virus (fpv) in a 3-month-old male kitten, with the presence of a parvovirus variant which is a true intermediate between cpv and fpv. the report of a viral variant which contained fpv- and cpv-specific epitopes stresses the importance of the mechanism of multistep mutation in the production of new variants and in the emergence of new viruses. this type of multistep adaptation has alread ... | 2015 | 23564594 |
| risk factors for exposure to feline pathogens in california mountain lions (puma concolor). | the primary challenge to mountain lion population viability in california is habitat loss and fragmentation. these habitat impacts could enhance disease risk by increasing contact with domestic animals and by altering patterns of exposure to other wild felids. we performed a serologic survey for feline pathogens in california mountain lions (puma concolor) using 490 samples from 45 counties collected from 1990 to 2008. most mountain lions sampled were killed because of depredation or public safe ... | 2013 | 23568903 |
| an updated taqman real-time pcr for canine and feline parvoviruses. | canine parvovirus type 2 (cpv-2) emerged in late 1970s from the feline panleukopenia virus (fplv) and developed, since then, into novel genetic and antigenic variants (cpv-2a, -2b and -2c). canine and feline parvoviruses cause an acute enteric disease in their hosts, with high level of viral shedding. in this study, a quantitative taqman pcr for detection and quantitation of canine and feline parvoviruses in serum and fecal samples was developed. the primers were designed based upon the entire g ... | 2013 | 23680092 |
| prevention of infectious diseases in cat shelters: abcd guidelines. | recommendations are given in relation to infectious diseases in rescue shelters. the abcd recognises that there is a wide variation in the design and management of shelters, and that these largely reflect local pressures. these guidelines are written with this diverse audience in mind; they point to the ideal, and also provide for some level of compromise where this ideal cannot immediately be attained. in addition consideration should be given to general requirements in order to optimise overal ... | 2013 | 23813812 |
| case series of feline panleukopenia virus in an animal shelter. | the aim of this study was to describe a series of confirmed and suspected cases of feline panleukopenia virus (fpv) and in-contact cats in an adoption-guarantee shelter in an fpv-endemic area by reviewing shelter records over a 10-month period (january-october 2010). cats were divided into three groups: in-contact group - asymptomatic cats that were housed with a fpv fecal antigen (ag)-positive cat/kitten as part of a litter group (n = 66); fpv-survivors group (fpv-infected survivors) - tested f ... | 2014 | 23873047 |
| tail vaccination in cats: a pilot study. | feline injection site sarcomas affect 1-10 cats per every 10,000 vaccinated and are associated with high mortality. radical resection may be curative, but is often associated with prolonged recovery, disfigurement and loss of function when tumors occur at currently recommended injection sites. the objective of this study was to assess alternatives to currently recommended vaccination sites in terms of preference by oncology practitioners, ease of injection and serological responses. surgical, ra ... | 2014 | 24108201 |
| enteropathogen co-infection in uk cats with diarrhoea. | individual enteropathogen infections in healthy and clinically ill cats are well described, but prevalence and patterns of enteropathogen co-infection have only been reported on a limited basis. we studied enteropathogen co-infection in diarrhoeic uk cats using results of a real time pcr assay for 8 enteropathogenic species; feline coronavirus (co), feline panleukopenia virus (pa), clostridium perfringens (cl), salmonella enterica (sa), giardia spp. (gi), tritrichomonas foetus (tr), cryptosporid ... | 2014 | 24410914 |
| prevalence of antibodies against feline panleukopenia virus in client-owned cats in southern germany. | feline panleukopenia is a frequent and commonly fatal disease of cats. recent published studies have raised suspicions that some cats fail to develop antibodies after vaccination. the purpose of this study was to assess the prevalence of antibodies against feline panleukopenia virus (fpv) in cats in southern germany, and to identify factors that are associated with a lack of antibodies. in total, 350 cats presented to the clinic of small animal medicine, ludwig-maximilians-universitaet were rand ... | 2014 | 24461646 |
| evaluation of an in-house dot enzyme-linked immunosorbent assay to detect antibodies against feline panleukopenia virus. | measuring antibody titres to determine a cat's immunity to core diseases instead of just administering annual vaccinations has not been established in germany so far. an in-house test kit for the detection of antibodies against feline panleukopenia virus (fpv), feline herpesvirus-1 and feline calicivirus-- the immunocomb feline vaccicheck--is now available in several european countries. the aim of this study was to assess the quality of the immunocomb feline vaccicheck to determine antibodies by ... | 2014 | 24496322 |
| canine parvovirus 2c infection in a cat with severe clinical disease. | canine parvovirus 2 (cpv-2) is considered the main pathogen responsible for acute gastroenteritis in dogs, causing vomiting and hemorrhagic enteritis mainly. however, infection in cats by cpv variants causes clinical signs similar to feline panleukopenia virus. the current study reports a case of cpv-2c in a domestic cat, in portugal. the findings suggest that more surveys are needed to know the true prevalence and significance of cats in cpv epidemiology worldwide. | 2014 | 24670953 |
| severe, diffuse fibrinonecrotic pleuropneumonia in a cat affected by multiple viral infection. | this communication describes the coinfection with feline panleukopenia virus (fpv), feline herpesvirus 1 (fehv-1), feline calicivirus (fcv) and feline coronavirus (fcov) in a 1 year‑old domestic cat living in a feline shelter. the cat was referred to veterinary hospital with clinical signs related to diffuse gastro-intestinal inflammation, it had developed a severe pneumopathy with fibrinous exudation in all body cavities and died 8 days after initial presentation. pathological findings and biom ... | 2014 | 24817332 |
| effect of high-dose ciclosporin on the immune response to primary and booster vaccination in immunocompetent cats. | ciclosporin (atopica oral solution for cats 100 mg/ml; novartis animal health) was recently approved for use in cats with feline hypersensitivity dermatitis. the immunosuppressant effect of ciclosporin on the ability of cats to mount an immune response following vaccination was determined. thirty-two healthy, immunocompetent adult cats (16 cats/group) were treated with either ciclosporin for 56 days at a dose of 24 mg/kg once daily or sham dosed. prior to treatment, cats had an adequate antibody ... | 2015 | 24820998 |
| efficacy of passively transferred antibodies in cats with acute viral upper respiratory tract infection. | a commercial hyperimmune serum, containing antibodies against feline calicivirus (fcv), feline herpesvirus 1 (fhv-1), and feline panleukopenia virus, is available for treatment of cats with feline upper respiratory tract disease (furtd), but its efficacy has not been rigorously evaluated in scientific studies. the aim of this randomised, placebo-controlled, double-blind clinical trial was to evaluate the efficacy of passive immunisation in cats with acute viral furtd caused by fcv and/or fhv-1 i ... | 2014 | 24929533 |
| faecal virome of cats in an animal shelter. | we describe the metagenomics-derived feline enteric virome in the faeces of 25 cats from a single shelter in california. more than 90 % of the recognizable viral reads were related to mammalian viruses and the rest to bacterial viruses. eight viral families were detected: astroviridae, coronaviridae, parvoviridae, circoviridae, herpesviridae, anelloviridae, caliciviridae and picobirnaviridae. six previously known viruses were also identified: feline coronavirus type 1, felid herpes 1, feline cal ... | 2014 | 25078300 |
| host-specific parvovirus evolution in nature is recapitulated by in vitro adaptation to different carnivore species. | canine parvovirus (cpv) emerged as a new pandemic pathogen of dogs in the 1970s and is closely related to feline panleukopenia virus (fpv), a parvovirus of cats and related carnivores. although both viruses have wide host ranges, analysis of viral sequences recovered from different wild carnivore species, as shown here, demonstrated that>95% were derived from cpv-like viruses, suggesting that cpv is dominant in sylvatic cycles. many viral sequences showed host-specific mutations in their capsid ... | 2014 | 25375184 |
| a ten-year molecular survey on parvoviruses infecting carnivores in bulgaria. | parvoviruses represent the most important infectious agents that are responsible for severe to fatal disease in carnivores. this study reports the results of a 10-year molecular survey conducted on carnivores in bulgaria (n = 344), including 262 dogs and 19 cats with gastroenteritis, and 57 hunted wild carnivores. real-time polymerase chain reaction (qpcr), followed by virus characterization by minor groove binder (mgb) probe assays, detected 216 parvovirus positive dogs with a predominance of c ... | 2016 | 25382194 |
| development of a nanoparticle-assisted pcr (nanopcr) assay for detection of mink enteritis virus (mev) and genetic characterization of the ns1 gene in four chinese mev strains. | mink enteritis virus (mev) causes mink viral enteritis, an acute and highly contagious disease whose symptoms include violent diarrhea, and which is characterized by high morbidity and mortality. nanoparticle-assisted polymerase chain reaction (nanopcr) is a recently developed technique for the rapid detection of bacterial and viral dna. here we describe a novel nanopcr assay for the clinical detection and epidemiological characterization of mev. | 2015 | 25582057 |
| complete genome sequence of feline panleukopenia virus strain hrb-cs1, isolated from a domestic cat in northeastern china. | here, we report the complete genome sequence of feline panleukopenia virus (fplv) strain hrb-cs1, isolated from a dead domestic cat showing enteric symptoms in china in 2014. the genome of hrb-cs1 was sequenced and analyzed, which will help to understand the genetic characteristics and evolution of fplv in china. | 2015 | 25814618 |
| an insulated isothermal pcr method on a field-deployable device for rapid and sensitive detection of canine parvovirus type 2 at points of need. | canine parvovirus type 2 (cpv-2), including subtypes 2a, 2b and 2c, causes an acute enteric disease in both domestic and wild animals. rapid and sensitive diagnosis aids effective disease management at points of need (pon). a commercially available, field-deployable and user-friendly system, designed with insulated isothermal pcr (iipcr) technology, displays excellent sensitivity and specificity for nucleic acid detection. an iipcr method was developed for on-site detection of all circulating cp ... | 2015 | 25889355 |
| feline panleukopenia virus in cerebral neurons of young and adult cats. | perinatal infections with feline panleukopenia virus (fpv) have long been known to be associated with cerebellar hypoplasia in kittens due to productive infection of dividing neuroblasts. fpv, like other parvoviruses, requires dividing cells to replicate which explains the usual tropism of the virus for the digestive tract, lymphoid tissues and bone marrow in older animals. | 2016 | 26895627 |
| genetic analysis of feline panleukopenia virus full-length vp2 gene in domestic cats between 2006-2008 and 2012-2014, portugal. | feline panleukopenia virus (fpv) and canine parvovirus (cpv) are two closely related viruses, which cause acute gastroenteritis in carnivores, and cats may be infected by strains of both viruses. the viruses are found worldwide and may have changing host ranges and genetic variation that can be found around the world in some cases. here, we screened a portuguese population of cats by a conventional pcr assay for the presence of fpv/cpv viruses in faecal samples and tissues between 2006-2008 and ... | 2016 | 26924760 |
| feline panleukopaenia virus in captive non-domestic felids in south africa. | an outbreak of feline panleukopaenia virus (fplv) infection was diagnosed by pathology, electron microscopy and polymerase chain reaction (pcr) in vaccinated captive-bred subadult cheetahs in south africa. subsequent to this disease outbreak, 12 cases of fplv diagnosed on histology were confirmed by pcr in captive african black-footed cat, caracal, cheetah, lion, ocelot and serval. phylogenetic analyses of the viral capsid protein gene on pcr-positive samples, vaccine and national center for bio ... | 2016 | 27380652 |
| molecular characterisation of parvoviruses from domestic cats reveals emergence of newer variants in india. | the present study was undertaken to characterise the viral polypeptide 2 (vp2) gene of parvovirus from domestic cats in india. | 2016 | 27502089 |
| surveillance for viral and parasitic pathogens in a vulnerable african lion (panthera leo) population in the northern tuli game reserve, botswana. | african lion ( panthera leo ) numbers are decreasing rapidly and populations are becoming smaller and more fragmented. infectious diseases are one of numerous issues threatening free-ranging lion populations, and low-density populations are particularly at risk. we collected data on the prevalence and diversity of viral and parasitic pathogens in a small lion population in eastern botswana. during 2012 and 2014, blood samples were collected from 59% (n=13) of the adult-subadult lions in the nort ... | 2017 | 27669009 |
| serosurvey for selected viral pathogens among sympatric species of the african large predator guild in northern botswana. | the recent increase in the creation of transboundary protected areas and wildlife corridors between them lends importance to information on pathogen prevalence and transmission among wildlife species that will become connected. one such initiative is the kavango zambezi transfrontier conservation area of which botswana's okavango delta constitutes a major contribution for wildlife and ecosystems. between 2008 and 2011, we collected serum samples from 14 lions ( panthera leo ), four leopards ( pa ... | 2017 | 27763827 |
| cell cycle s phase markers are expressed in cerebral neuron nuclei of cats infected by the feline panleukopenia virus. | the cell cycle-associated neuronal death hypothesis, which has been proposed as a common mechanism for most neurodegenerative diseases, is notably supported by evidencing cell cycle effectors in neurons. however, in naturally occurring nervous system diseases, these markers are not expressed in neuron nuclei but in cytoplasmic compartments. in other respects, the feline panleukopenia virus (fpv) is able to complete its cycle in mature brain neurons in the feline species. as a parvovirus, the fpv ... | 2016 | 27830988 |
| identification of inonotus obliquus polysaccharide with broad-spectrum antiviral activity against multi-feline viruses. | inonotus obliquus polysaccharides (iops) are a potential drug for the prevention and treatment of cancer, cardiopathy, diabetes, aids, pancreatitis and other diseases. in this study, we found that iop can act as a broad-spectrum antiviral drug against feline viruses in the in vitro experiment. using cell models of feline calicivirus (fcv), we demonstrated that iop treatment was capable of exhibiting anti-fcv strain f9 activity in cell-based assays and also showed low cytotoxicity. investigation ... | 2017 | 27865960 |
| recombinase polymerase amplification assay-a simple, fast and cost-effective alternative to real time pcr for specific detection of feline herpesvirus-1. | feline herpesvirus 1 (fhv-1), an enveloped dsdna virus, is one of the major pathogens of feline upper respiratory tract disease (urtd) and ocular disease. currently, polymerase chain reaction (pcr) remains the gold standard diagnostic tool for fhv-1 infection but is relatively expensive, requires well-equipped laboratories and is not suitable for field tests. recombinase polymerase amplification (rpa), an isothermal gene amplification technology, has been explored for the molecular diagnosis of ... | 2017 | 28045956 |
| feline panleucopenia virus ns2 suppresses the host ifn-β induction by disrupting the interaction between tbk1 and sting. | feline panleucopenia virus (fpv) is a highly infectious pathogen that causes severe diseases in pets, economically important animals and wildlife in china. although fpv was identified several years ago, little is known about how it overcomes the host innate immunity. in the present study, we demonstrated that infection with the fpv strain philips-roxane failed to activate the interferon β (ifn-β) pathway but could antagonize the induction of ifn stimulated by sendai virus (sev) in f81 cells. sub ... | 2017 | 28125002 |