Publications
| Title | Abstract | Year Filter | PMID(sorted ascending) Filter |
|---|
| [quantitative fluorogenic real-time pcr assay for respiratory syncytial virus detection]. | to establish a rapid and objective quantitative fluorogenic real-time pcr assay for early detection of human respiratory syncytial virus (hrsv). | 2005 | 16027084 |
| ten-year analysis of adenovirus type 7 molecular epidemiology in korea, 1995-2004: implication of fiber diversity. | adenovirus type 7 (ad7) is frequently responsible for severe respiratory infections, especially in young infants. since the ad7 epidemics have been associated with severe childhood pneumonia and significant mortality in korea, 1995-1999, continuous surveillance was necessary for ad7 related diseases. | 2006 | 16458589 |
| influence of sv40 genome on the replication of an adenovirus-sv40 "hybrid" population. | feldman, l. a. (baylor university college of medicine, houston, tex.), j. l. melnick, and f. rapp. influence of sv40 genome on the replication of an adenovirus-sv40 "hybrid" population. j. bacteriol. 90:778-782. 1965.-replication of a type 7 adenovirus-sv40 hybrid population in primary african green monkey kidney cells was accompanied by the formation of sv40 tumor antigen, adenovirus antigens, and cytopathic changes characteristic of adenovirus infection. prior infection of the cultures with sv ... | 1965 | 16562080 |
| detection of biologically active adenovirions unable to plaque in human cells. | butel, janet s. (baylor university college of medicine, houston, tex.), joseph l. melnick, and fred rapp. detection of biologically active adenovirions unable to plaque in human cells. j. bacteriol. 92:433-438. 1966.-plaque formation in green monkey kidney (gmk) cells by a defective simian virus 40-adenovirus 7 "hybrid" population (para-adenovirus 7) was enhanced by the addition of excess adenovirions. adenovirus types 2, 7, and 12 were capable of providing enhancement, although none of these vi ... | 1966 | 16562132 |
| density differences between hybrid and nonhybrid particles in two adenovirus-simian virus 40 hybrid populations. | the adenovirus 7-simian virus 40 hybrid virus population e46(+) was subjected to fixed-angle equilibrium density gradient centrifugation in cscl. a difference in buoyant density between the hybrid virion and its nonhybrid adenovirus 7 counterpart was noted, the hybrid virion possessing the lower buoyant density. this difference in buoyant density appeared to be accentuated in a population of adenovirus 2(+t7), a derivative of e46(+) in which the adenovirus 7-simian virus 40 genome had been trans ... | 1970 | 16789126 |
| simian virus 40 dna segment of the adenovirus 7-simian virus 40 hybrid, e46, and its transcription during permissive infection of monkey kidney cells. | nucleic acid hybridization methodology has been used to investigate the span of the simian virus 40 (sv40) dna segment in the adenovirus 7-sv40 hybrid, e46(+), and the extent of its transcription in lytically infected monkey kidney cells. the sv40 segment of e46(+) comprises approximately 62% of the sv40 genome; it originates in the proximal region of hin-g (the g fragment derived by cleavage of intact sv40 dna with haemophilus influenzae restriction endonuclease), extends sequentially through a ... | 1975 | 16789154 |
| structure of the dna of the adenovirus 7-simian virus 40 hybrid, e46, by electron microscopy. | the dna molecule of the adenovirus 7-simian virus (sv) 40 hybrid, e46(+), contains a single substitution of sv40 dna located about 0.05 adenovirus 7 lengths from one end (arbitrarily designated the left end). the left to right direction in the sv40 dna segment of the hybrid corresponds to the clockwise direction in the sv40 physical map. the left end point of the segment maps at about sv40 map position 0.50 +/- 0.01 and the right end point at about sv40 map position 0.66 +/- 0.01. the region bet ... | 1975 | 16789158 |
| a slow spread of adenovirus type 7 infection after its re-emergence in yamagata, japan, in 1995. | we have continued the epidemiological study on adenovirus type 7 (ad7), which re-emerged in 1995 in yamagata, japan. between 1999 and 2004, we isolated only four strains from 10,778 throat swab specimens among children with acute respiratory infections. a serological survey of 303 specimens revealed the antibody-positive rate against ad7 to be 0-7.4% in children under 10 years of age in 2005, although it was 3.3-16.7% in 1997 and 0% in 1993. our results suggest that a re-emergence does not alway ... | 2006 | 16858147 |
| calcium-dependent viral internalization is required for adenovirus type 7 induction of il-8 protein. | the host response to adenovirus (ad) infection involves induction of cytokines in lung epithelia. we have demonstrated induction of the lung neutrophil chemokine interleukin-8 (il-8) by ad7, a major lung pathogen, in a549 lung epithelial cells and lung tissue through activation of the erk signaling pathway. however, the mechanism of il-8 induction is still unclear. in this paper, we first showed that ad7 viral gene expression is not essential for il-8 induction as psoralen-uv inactivation of ad7 ... | 2006 | 16890267 |
| association of bovine respiratory disease with clinical status and acute phase proteins in calves. | eighty-four calves with respiratory disease from 18 herds in different parts of finland were chosen for a study evaluating the capacity of different respiratory pathogens to cause changes in different acute phase protein concentrations, white blood cell (wbc) count and clinical signs. the selected acute phase proteins were fibrinogen, haptoglobin, serum amyloid-a, lipopolysaccharide binding protein and alpha1-acid glycoprotein. from each calf, a paired blood sample was obtained for serological s ... | 2007 | 17258318 |
| antiviral activity of arbidol against influenza a virus, respiratory syncytial virus, rhinovirus, coxsackie virus and adenovirus in vitro and in vivo. | arbidol, ethyl-6-bromo-4-[(dimethylamino)-methyl]-5-hydroxy-1-methyl-2-[(phenylthio)methyl]-in dole-3-carboxylate hydrochloride monohydrate, is an antiviral chemical agent. in this report, we studied the antiviral activity of arbidol against a panel of human respiratory viruses, namely influenza a virus (flu-a, a/pr/8/34 h1n1), respiratory syncytial virus (rsv), human rhinovirus type 14 (hrv 14), coxsackie virus b3 (cvb3) and adenovirus type 7 (adv-7) in vitro in cell culture. arbidol was found ... | 2007 | 17497238 |
| adenovirus multiplication: genetic relatedness of tumorigenic human adenovirus types 7, 12, and 18. | hybridization measurements among the dna's of six weakly tumorigenic strains of human adenovirus type 7 reveal that all six strains are very closely related (83- to 110-percent nucleotide sequence homology). the dna homology between these six type 7 strains and nontumorigenic types 2 and 4 is 32 percent and 52 percent, respectively. the 10- to 20-percent homology between the type 7 dna's and those of "potent" tumorigenic types 12 and 18 indicates a very low degree of genetic relatedness. these d ... | 1965 | 17751853 |
| etiology of acute diarrhea in children and adults in tunis, tunisia, with emphasis on diarrheagenic escherichia coli: prevalence, phenotyping, and molecular epidemiology. | a total of 271 stool specimens were collected from children (diarrheagenic, n = 115 and control, n = 54) and adults (diarrheagenic, n = 73 and control, n = 29) from tunis, tunisia, and processed to detect bacterial enteropathogens, parasites, and viruses. diarrheagenic escherichia coli (dec) were identified by their virulence genes (polymerase chain reaction) and adherence patterns (tissue culture assays). the most frequently isolated enteric pathogens from diarrheagenic children were enterotoxi ... | 2007 | 17827382 |
| [identification and typing for adenovirus by multiplex nest-pcr]. | to develop a rapid, sensitive and specific method in identifying and typing on adenovirus from clinical specimens. | 2007 | 18080566 |
| evaluation of the pathogenic potential of cervid adenovirus in calves. | four 3-month-old jersey calves and three 3-month-old holstein calves were inoculated with cervid adenovirus and monitored for clinical signs until necropsied between 10 and 42 days postinoculation. the neonatal jersey calves had received colostrum, and the holstein calves were colostrum deprived. preinoculation and postinoculation serum samples were tested for antibodies to the cervid adenovirus, bovine adenovirus type 6, bovine adenovirus type 7, and goat adenovirus type 1. virus isolation was ... | 2008 | 18182505 |
| serologic and hexon phylogenetic analysis of ruminant adenoviruses. | the objectives of this study were to determine the antigenic relationship among ruminant adenoviruses and determine their phylogenetic relationship based on the deduced hexon gene amino acid sequence. results of reciprocal cross-neutralization tests demonstrated antigenic relationships in either one or both directions among bovine adenovirus type 6 (badv-6), badv-7, ovine adenovirus type 7 (oadv-7), caprine adenovirus type 1 (gadv-1), and deer adenovirus (odocoileus adenovirus 1, odadv-1). no an ... | 2008 | 18340400 |
| health evaluation of free-ranging humboldt penguins (spheniscus humboldti) in peru. | as part of ongoing ecological studies of humboldt penguins (spheniscus humboldti) at punta san juan, ica department, peru, health surveys were conducted in november 1992, 1993, and 1994. in the three surveys, 98 birds in total were handled for examination, and blood was collected for laboratory analysis from 90 of these birds. all birds seemed to be in good condition. body weights of females were significantly lower in 1994 than in the other years. fleas (parapsyllus humboldti) and ticks (ornith ... | 2008 | 18459309 |
| rate of concurrent otitis media in upper respiratory tract infections with specific viruses. | to estimate the coincidence of new otitis media (om) for first nasopharyngeal detections of the more common viruses by polymerase chain reaction (pcr). new om episodes are usually coincident with a viral upper respiratory tract infection (vurti), but there are conflicting data regarding the association between specific viruses and om. | 2009 | 19153302 |
| [sequence analysis for hexon genes of types 3, 7 and 11 of adenoviruses identified in beijing]. | the objective of this study was to develop a rapid, sensitive and specific method for identifying and typing for adenovirus from clinical specimens and to learn about the viruses identified in beijing on the molecular bases. | 2008 | 19173889 |
| adenovirus infections within a family cohort in iran. | adenovirus is one of the most frequent viruses associated with acute respiratory infections (ari). there is limited information of its transmission within the community. | 2009 | 19598232 |
| prevalence of diarrhea viruses in hospitalized children in hong kong in 2008. | a total of 209 stool samples were collected from pediatric patients admitted for acute gastroenteritis in a hospital in hong kong, during an 8-month period from january to august 2008, and were tested for the presence of rotavirus, norovirus, sapovirus, adenovirus, and astrovirus using a multiplex rt-pcr assay. the most common virus was rotavirus group a (59 of 209, 28%, mainly serotypes g1, g2, g3, and g9), followed by norovirus group ii (48 of 209, 23%), adenovirus (7 of 209, 3%, serotypes 2, ... | 2009 | 19774686 |
| ovine atadenovirus, a novel and highly immunogenic vector in prime-boost studies of a candidate hiv-1 vaccine. | ovine adenovirus type 7 (oadv) is the prototype member of the genus atadenovirus. no immunity to the virus has so far been detected in human sera. we describe the construction and evaluation of a candidate hiv-1 vaccine based on oadv and its utilisation alone and in combination with plasmid-, human adenovirus type 5 (hadv5; a mastadenovirus)-, and modified vaccinia ankara (mva)-vectored vaccines. all vectors expressed hiva, an immunogen consisting of hiv-1 clade a consensus gag-derived protein c ... | 2009 | 19853074 |
| human lung innate immune cytokine response to adenovirus type 7. | adenovirus (ad) type 7 can cause severe infection, including pneumonia, in military recruits and children. the initial inflammation is a neutrophilic interstitial infiltration with neutrophilic alveolitis. subsequently, monocytes become evident and, finally, there is a predominantly lymphocytic infiltrate. we have established that ad7 infection of epithelial cells stimulates release of the neutrophil chemotaxin interleukin (il)-8, and have extended these studies to a human lung tissue model. her ... | 2010 | 20071488 |
| repair of large cranial defects by hbmp-2 expressing bone marrow stromal cells: comparison between alginate and collagen type i systems. | despite a wide range of available sources for bone repair, significant limitations persist. to bioengineer bone, we have previously transferred adenovirus-mediated human bmp-2 gene into autologous bone marrow stromal cells (msc). we have successfully repaired large, full thickness, cranial defects using this approach. we report now the effectiveness of various hydrogels as the scaffold for this type of bone regeneration, comparing specifically alginate with type i collagen. cultured msc of minia ... | 2010 | 20186742 |
| noroviruses as cause of gastroenteritis in elderly patients. | background and aims. gastroenteritis is one of the infections that are particularly important to the elderly people. the knowledge of the main pathogens causing gastroenteritis in this group of patients, whose number will be dramatically increased in coming decades, is essential. the contribution of group a rotavirus, adenovirus type 41 and 42, norovirus and astrovirus as cause of gastroenteritis among patients of all ages, especially those with more than 65 years old over an extended time perio ... | 2010 | 20460955 |
| adenovirus serotype 7 associated with a severe lower respiratory tract disease outbreak in infants in shaanxi province, china. | pneumonia caused by adenovirus infection is usually severe especially with adenovirus serotype 7 commonly associated with lower respiratory tract disease outbreaks. we reported an outbreak of 70 cases of severe pneumonia with one death of infants in shaanxi province, china. sampling showed adenovirus 7 (ad7) as the primary pathogen with some co-infections. | 2011 | 21241515 |
| complete genome analysis of a novel e3-partial-deleted human adenovirus type 7 strain isolated in southern china. | human adenovirus (hadv) is a causative agent of acute respiratory disease, which is prevalent throughout the world. recently there are some reports which found that the hadv-3 and hadv-5 genomes were very stable across 50 years of time and space. but more and more recombinant genomes have been identified in emergent hadv pathogens and it is a pathway for the molecular evolution of types. in our paper, we found a hadv-7 gz07 strain isolated from a child with acute respiratory disease, whose genom ... | 2011 | 21371333 |
| construction of gene transfer vectors based on simian adenovirus 7. | the complete nucleotide sequence of an isolate of simian adenovirus 7 (sadv-7) was determined. the genome organization of this isolate was found to be similar to that of other primate adenoviruses with two principal notable points; severe truncation of the e1a and e1b 19k proteins and an e3 region encoding only the 12.5k homolog. the viral gene products of sadv-7 are most closely related to simian adenovirus 1 (sadv-1), and like sadv-1, are related to the human adenovirus species hadv-f, such as ... | 2011 | 21562118 |
| [pneumonia due to adenovirus type 7: a case report in a healthy infant.] | a 15-month-old boy treated with amoxicillin and clavulanic acid therapy for 8 days was admitted for persistent gastroenteritis and fever. he received ceftriaxone for pneumonia modified on day 4 for cefotaxime and josamycin due to extension of alveolar lesions. on day 7, persistent fever and worsened respiratory distress led to addition of rifampicin. the child was then admitted to an intensive care unit. a hemophagocytic syndrome was suspected based on clinical signs and laboratory findings and ... | 2011 | 21571511 |
| A naturally occurring human adenovirus type 7 variant with a 1743 bp deletion in the E3 cassette. | Human adenovirus type 7 (HAdV-7) is an important cause of acute respiratory disease (ARD). Different genomic variants of HAdV-7 have been described, designated 7a to 7l. In a previous study to investigate risk factors for ARD and wheezing, nasopharyngeal samples were collected from 90 ill children seeking medical attention in Ribeir+úo Preto, SP, Brazil. HAdVs were identified in 31 samples and were characterized by serum neutralization and genome restriction analysis. Eleven HAdVs were identifie ... | 2011 | 21677090 |
| an outbreak of adenovirus type 7 in a residential facility for severely disabled children. | background:: adenoviruses cause a variety of clinical symptoms, involving the respiratory, gastrointestinal, urogenital, and neurologic systems. only a few of the 55 known serotypes of adenovirus that affect humans can cause outbreaks of respiratory tract infection. aim:: to describe the characteristics and clinical manifestations of severe respiratory disease contracted by 8 physically and cognitively disabled children during a very short outbreak of adenovirus serotype 7 infection in a residen ... | 2011 | 21694661 |
| adenovirus pneumonia in an immunocompetent adult. | adenovirus pneumonias are reported relatively commonly in pediatric or immunocompromised patients, but the clinical presentation of adenovirus pneumonia in immunocompetent hosts is not well known. we treated an immunocompetent 42-year-old man with mild adenovirus pneumonia following pharyngitis and conjunctivitis. diagnosis was established on the basis of chest radiologic findings, detection of adenovirus type 7 dna by pcr assay in material obtained from bronchoalveolar lavage (bal), and a great ... | 2012 | 22350400 |
| infectious etiologies of transient neutropenia in previously healthy children. | healthy children presenting with neutropenia are often hospitalized and treated empirically with antibiotics without an evidence of infection. the objective of this study was to investigate the infectious causes of isolated transient neutropenia in otherwise previously healthy children. | 2012 | 22414904 |
| human adenovirus type 7 outbreak in police training center, malaysia, 2011. | in march 2011, an outbreak of acute respiratory disease was reported at the kuala lumpur (malaysia) police training centre. approximately 100 trainees were hospitalized and 5 were admitted to the intensive care unit. three of these 5 trainees died. human adenovirus type 7 was identified as the etiologic agent. | 2012 | 22515984 |
| synthesis, pharmacological activity evaluation and molecular modeling of new polynuclear heterocyclic compounds containing benzimidazole derivatives. | novel heterocyclic compounds containing benzimidazole derivatives were synthesized from 2-(1h-benzimidazol-2-yl) acetonitrile (1) and arylhydrazononitrile derivative 2 was obtained via coupling of 1 with 4-methyl phenyldiazonium salt, which was then reacted with hydroxylamine hydrochloride to give amidooxime derivative 3. this product was cyclized into the corresponding oxadiazole derivative 4 upon reflux in acetic anhydride. compound 4 was refluxed in dmf in the presence of triethylamine to giv ... | 2012 | 23263801 |
| complete genome sequence of human adenovirus type 7 associated with fatal infant pneumonia. | the chinese human adenovirus 7 (hadv7) 0901hz/shx/chn/2009 was isolated from the hydrothorax fluid of an infant with fatal pneumonia in shaanxi, china, in 2009. comparison of the entire genome with the genomes of the other 10 strains of hadv7 from genbank revealed homologies of 89.9 to 99.9%, with geographic polymorphism among hadv-7 field strains circulating in mainland china. | 2013 | 23409258 |
| a retrospective study of disease in elasmobranchs. | this report reviews diseases of 1546 elasmobranchs representing at least 60 species submitted to northwest zoopath from 1994 to 2010. cownose rays (rhinoptera bonasus) (78), southern rays (dasyatis americana) (75), dusky smooth-hounds (mustelus canis) (74), bonnethead sharks (sphyrna tiburo) (66), and bamboo sharks (hemiscylliidae) (56) were the most commonly submitted species. infectious/inflammatory disease was most common (33.5%) followed by nutritional (11.9%, mostly emaciation), traumatic ( ... | 2013 | 23528944 |
| synthesis and antiviral evalution of some novel pyrazoles and pyrazolo[3,4-d]pyridazines bearing 5,6,7,8-tetrahydronaphthalene. | the enaminone 2 was reacted with hydrazonyl halides 3a-d to afford the corresponding pyrazole derivatives (6a-d) which reacted with hydrazine hydrate to afford the new pyrazolo[3,4-d]pyridazine derivatives 7a-d, respectively. in addition, compound 2 was reacted with some primary aromatic amines to afford the corresponding secondary enaminones 10a-c and reacted with sulfapyridine or sulfapyrimidine to afford the corresponding sulfonamide derivatives 12a and 12b. evaluation of these new compounds ... | 2013 | 23610964 |
| outbreak of acute respiratory disease caused by human adenovirus type 7 in a military training camp in shaanxi, china. | outbreaks of ard associated with hadv have been reported in military populations in many countries. here, we report an ard outbreak caused by hadv-7 in a military training camp in shaanxi province, china, from february to march of 2012. epidemic data and samples from the patients were collected, and viral nucleotides from samples and viral isolations were detected and sequenced. igg and iga antibodies against hadv, and the neutralization antibodies against the viral strain isolated in this outbr ... | 2013 | 23734976 |
| antiviral activity of folium isatidis derived extracts in vitro and in vivo. | folium isatidis is a native chinese herbaceous plant widely used for medicinal purposes for thousands of years. however, few studies have focused on the leaves of isatis indigotica. in this report, we isolated a series of four fractions (i-iv) from folium isatidis and explored the antiviral activity of each tested extract. the extracts were active against a panel of rna and dna viruses in vitro, namely influenza a virus (iav), coxsackie virus b3 (cvb3), respiratory syncytial virus (rsv), and ade ... | 2013 | 23895163 |
| molecular classification of human adenovirus type 7 isolated from acute respiratory disease outbreak (ard) in korea, 2005-2006. | to assess the genomic characteristics of human adenoviruses (hadvs) that caused small-scale epidemics in korea and compare sequence analysis and restriction fragment length polymorphism (rflp). | 2010 | 24159434 |
| vaccines within vaccines: the use of adenovirus types 4 and 7 as influenza vaccine vectors. | adenovirus types 4 and 7 (ad4 and ad7) are associated with acute respiratory distress (ard). in order to prevent widespread ad-associated ard (ad-ard) the united states military immunizes new recruits using a safe and effective lyophilized wildtype ad4 and ad7 delivered orally in an enteric-coated capsule. we cloned ad4 and ad7 and modified them to express either a gfp-luciferase (gfpluc) fusion gene or a centralized influenza h1 hemagglutinin (ha1-con). balb/c mice were injected with gfpluc exp ... | 2014 | 24280656 |
| impact of human adenovirus serotype 7 in hospitalized children with severe fatal pneumonia in the philippines. | human adenovirus (hadv) serotype 7 is an important etiological agent of severe childhood pneumonia. the aim of this study was to define the role of hadv7 and to describe its clinical and molecular epidemiological characteristics in the philippines in 2011. hadvs were detected by viral culture, and a partial region of hexon gene was sequenced. a total of 700 patients were enrolled, of which 22 (3.1%) died. nine (1.3%) hadv cases were confirmed, of which 7 were positive for hadv7, 1 for hadv3, and ... | 2014 | 24647252 |
| antigenic variability among two subtypes of human adenovirus serotype 7. | human adenovirus type 7 (hadv-7) is one of the major serotypes responsible for acute respiratory infection. it is important to investigate the antigenic variabilities of different hadv-7 genomic subtypes for vaccine development. phylogenetic analysis of global hadv-7 strains and major antigen proteins showed that hadv-7 could be classified into two subtypes. there were three highly variable regions (hvr1, hvr4, and hvr7) in the hexon protein that varied between subtypes. within each of the subty ... | 2014 | 24760574 |
| increased mucosal cd4+ t cell activation in rhesus macaques following vaccination with an adenoviral vector. | the possibility that vaccination with adenovirus (adv) vectors increased mucosal t cell activation remains a central hypothesis to explain the potential enhancement of hiv acquisition within the step trial. modeling this within rhesus macaques is complicated because human adenoviruses, including human adenovirus type 5 (hadv-5), are not endogenous to macaques. here, we tested whether vaccination with a rhesus macaque-derived adenoviral vector (simian adenovirus 7 [sadv-7]) enhances mucosal t cel ... | 2014 | 24829340 |
| generation of neutralizing monoclonal antibodies against a conformational epitope of human adenovirus type 7 (hadv-7) incorporated in capsid encoded in a hadv-3-based vector. | the generation of monoclonal antibodies (mabs) by epitope-based immunization is difficult because the immunogenicity of simple peptides is poor and t cells must be potently stimulated and immunological memory elicited. a strategy in which antigen is incorporated into the adenoviral capsid protein has been used previously to develop antibody responses against several vaccine targets and may offer a solution to this problem. in this study, we used a similar strategy to develop hadv-7-neutralizing ... | 2014 | 25054273 |
| human adenovirus type 7 infection associated with severe and fatal acute lower respiratory illness and nosocomial transmission. | a 23-year-old male died of severe pneumonia and respiratory failure in a tertiary hospital in beijing, and 4 out of 55 close contacts developed fever. molecular analysis confirmed human adenovirus type 7 (hadv7) as the causative agent. we highlight the importance of early diagnosis and treatment and proper transmission control of hadv7. | 2015 | 25520444 |
| novel antiviral compounds against gastroenteric viral infections. | viral gastroenteritis is a serious viral infection which affects a large number of individuals around the world, most of them being children. the infection may occur due to different viruses, for example, coxsackievirus, adenovirus, and rotavirus. there is no available cure for such infections, and the treatment mainly depends on hospitalization and administration of nutritional supports. a new antiviral agent against gastroenteritis viral infection will be a breakthrough in healthcare. pyrrole ... | 2015 | 25704120 |
| heterologous prime-boost regimens with a recombinant chimpanzee adenoviral vector and adjuvanted f4 protein elicit polyfunctional hiv-1-specific t-cell responses in macaques. | hiv-1-specific cd4+ and cd8+ t lymphocytes are important for hiv-1 replication control. f4/as01 consists of f4 recombinant fusion protein (containing clade b gag/p24, pol/rt, nef and gag/p17) formulated in as01 adjuvant system, and was shown to induce f4-specific polyfunctional cd4+ t-cell responses in humans. while replication-incompetent recombinant hiv-1/siv antigen-expressing human adenoviral vectors can elicit high-frequency antigen-specific cd8+ t-cell responses, their use is hampered by w ... | 2015 | 25856308 |
| crystal structure of the fibre head domain of bovine adenovirus 4, a ruminant atadenovirus. | in adenoviruses, primary host cell recognition is generally performed by the head domains of their homo-trimeric fibre proteins. this first interaction is reversible. a secondary, irreversible interaction subsequently takes place via other adenovirus capsid proteins and leads to a productive infection. although many fibre head structures are known for human mastadenoviruses, not many animal adenovirus fibre head structures have been determined, especially not from those belonging to adenovirus g ... | 2015 | 25994880 |
| severe pediatric adenovirus 7 disease in singapore linked to recent outbreaks across asia. | during november 2012-july 2013, a marked increase of adenovirus type 7 (ad7) infections associated with severe disease was documented among pediatric patients in singapore. phylogenetic analysis revealed close genetic links with severe ad7 outbreaks in china, taiwan, and other parts of asia. | 2015 | 26079293 |
| prevalence of respiratory virus in symptomatic children in private physician office settings in five communities of the state of veracruz, mexico. | acute respiratory tract infections are the leading cause of morbidity and mortality in children worldwide. many studies have described the frequency of viruses in hospitalized patients, but studies describing the prevalence of viruses in the community setting are limited, particularly in developing countries, where most of the deaths from serious respiratory diseases occur. the aim of this study was to evaluate the diversity of respiratory viruses in the community setting using molecular diagnos ... | 2015 | 26108920 |
| significant transplantation-related mortality from respiratory virus infections within the first one hundred days in children after hematopoietic stem cell transplantation. | respiratory viral infections (rvi) are important in hematopoietic stem cell transplantations (hsct) and knowledge regarding incidence, morbidity, mortality, and long-term pulmonary complications is limited. we report a study to evaluate incidence and outcomes, both short and long-term, of rvi in children receiving hsct. between january 2000 and december 2012, 844 patients underwent hematopoietic stem cell transplantation (hsct) at the hospital for sick children: 491 were allogeneic and 353 were ... | 2015 | 26117558 |
| efficient induction of cross-presentating human b cell by transduction with human adenovirus type 7 vector. | although human autologous b cells represent a promising alternative to dendritic cells (dcs) for easy large-scale preparation, the naive human b cells are always poor at antigen presentation. the safe and effective usage record of human adenovirus type 7 (hadv7) live vaccines makes it attractive as a promising vaccine vector candidate. to investigate whether hadv7 vector could be used to induce the human b cells cross-presentation, in the present study, we constructed the e3-defective recombinan ... | 2016 | 26620361 |
| effective concentration, recovery, and detection of infectious adenoviruses from environmental waters. | current application of fecal indicator bacteria (fib) as an indicator of sewage contamination has its limitation and other alternative indicator systems are needed for enhanced monitoring of recreational water quality. to explore the potential use of human enteric viruses (hev) as a potential indicator, human adenovirus type 7 (hadv-7) was tested in this study as a model virus. through spiked hadv-7 into the sample seawater, different procedures for viral concentration and elution were comparati ... | 2016 | 26763204 |
| evaluation of epidemiological and clinical features of influenza and other respiratory viruses. | in our study, we aimed to clinically and epidemiologically evaluate respiratory tract infections the viral agents of which were detected by molecular methods and to compare influenza and other respiratory tract viruses in this context. | 2015 | 26884691 |
| adenovirus type 7 pneumonia in children who died from measles-associated pneumonia, hanoi, vietnam, 2014. | during a 2014 measles outbreak in vietnam, postmortem pathologic examination of hospitalized children who died showed that adenovirus type 7 pneumonia was a contributory cause of death in children with measles-associated immune suppression. adenovirus type 7 pneumonia should be recognized as a major cause of secondary infection after measles. | 2016 | 26926035 |
| human adenovirus associated with severe respiratory infection, oregon, usa, 2013-2014. | several human adenoviruses (hadvs) can cause respiratory infections, some severe. hadv-b7, which can cause severe respiratory disease, has not been recently reported in the united states but is reemerging in asia. during october 2013-july 2014, oregon health authorities identified 198 persons with respiratory symptoms and an hadv-positive respiratory tract specimen. among 136 (69%) hospitalized persons, 31% were admitted to the intensive care unit and 18% required mechanical ventilation; 5 patie ... | 2016 | 27191834 |
| severe pneumonia caused by adenovirus 7 in pregnant woman: case report and review of the literature. | we report a rare case of adenoviral pneumonia in a previously healthy pregnant woman at 26(+4) weeks' gestation. she presented with persistent high fever, cough for 5 days, and developed progressive dyspnea with hypoxemic respiratory failure and bilateral pulmonary infiltrates with pleural effusions. aggressive supportive care and timely obstetrical management saved the mother and prevented preterm delivery and fetal anomaly. | 2016 | 27325617 |
| epidemiology and transmission characteristics of human adenovirus type 7 caused acute respiratory disease outbreak in military trainees in east china. | human adenovirus type 7 (hadv7) is globally attracting great concern as its high morbidity and severity in respiratory diseases, especially in asia. | 2016 | 27347341 |
| respiratory microbes present in the nasopharynx of children hospitalised with suspected pulmonary tuberculosis in cape town, south africa. | lower respiratory tract infection in children is increasingly thought to be polymicrobial in origin. children with symptoms suggestive of pulmonary tuberculosis (ptb) may have tuberculosis, other respiratory tract infections or co-infection with mycobacterium tuberculosis and other pathogens. we aimed to identify the presence of potential respiratory pathogens in nasopharyngeal (np) samples from children with suspected ptb. | 2016 | 27776489 |
| complete genome sequence of human adenovirus 7 associated with fatal adult pneumonia. | human adenovirus 7 (hadv7) 19bovlb/volgograd/rus/2014 was isolated from the autopsy material from an adult with fatal pneumonia in volgograd, russia, in march 2014. whole-genome sequencing of the virus isolate was performed. | 2016 | 27789645 |
| development of a one-run real-time pcr detection system for pathogens associated with bovine respiratory disease complex. | bovine respiratory disease complex (brdc) is frequently found in cattle worldwide. the etiology of brdc is complicated by infections with multiple pathogens, making identification of the causal pathogen difficult. here, we developed a detection system by applying taqman real-time pcr (dembo respiratory-pcr) to screen a broad range of microbes associated with brdc in a single run. we selected 16 bovine respiratory pathogens (bovine viral diarrhea virus, bovine coronavirus, bovine parainfluenza vi ... | 2017 | 28070089 |
| molecular characterisation of fowl adenovirus type 7 isolated from poultry associated with inclusion body hepatitis in poland. | the fowl adenovirus field strain fadv-jsn-5/10j (genbank accession number kp879219) was isolated from the intestine of a 7-week-old chicken diagnosed with inclusion body hepatitis and simultaneously with marek's disease, and for that reason, it was chosen for molecular study. it was identified as fowl adenovirus genotype 7 (species fowl aviadenovirus e) based on nucleotide sequence analysis of the loop l1 region of the hexon gene. nucleotide sequence alignment of this strain, fadv-7 reference st ... | 2017 | 28160143 |
| an outbreak of acute respiratory disease caused by a virus associated rna ii gene mutation strain of human adenovirus 7 in china, 2015. | human adenovirus 7 (hadv-7) strains are a major cause of acute respiratory disease (ard) among adults and children, associated with fatal pneumonia. an ard outbreak caused by hadv-7 that involved 739 college students was reported in this article. to better understand the underlying cause of this large-scale epidemic, virus strains were isolated from infected patients and sequence variations of the whole genome sequence were detected. evolutionary trees and alignment results indicated that the ma ... | 2017 | 28225804 |
| clinical features of community acquired adenovirus pneumonia during the 2011 community outbreak in southern taiwan: role of host immune response. | human adenovirus 7 (hadv-7) was responsible for a significant number of fatalities during the 2011 community outbreak in taiwan. the mechanisms underlying the pathogenesis of severe adenovirus infections in non-immunocompromised individuals remain unclear. adenovirus pneumonia was associated with pleural effusion in a number of patients from the 2011 outbreak suggesting that similar to bacterial pneumonia, patients diagnosed with adenovirus pneumonia who have pleural effusion are more severely a ... | 2017 | 28270104 |
| bacterial and viral pathogen spectra of acute respiratory infections in under-5 children in hospital settings in dhaka city. | the study aimed to examine for the first time the spectra of viral and bacterial pathogens along with the antibiotic susceptibility of the isolated bacteria in under-5 children with acute respiratory infections (aris) in hospital settings of dhaka, bangladesh. nasal swabs were collected from 200 under-five children hospitalized with clinical signs of aris. nasal swabs from 30 asymptomatic children were also collected. screening of viral pathogens targeted ten respiratory viruses using rt-qpcr. b ... | 2017 | 28346512 |
| co-infection of fowl adenovirus with different immunosuppressive viruses in a chicken flock. | in poultry, fowl adenovirus (fadv) and immunosuppressive virus co-infection is likely to cause decreased egg production, inclusion body hepatitis, and pericardial effusion syndrome. in this study, fowl adenovirus infection was found in parental and descendent generations of chickens. we used quantitative polymerase chain reaction (pcr) and dot blot hybridization to detect the infection of reticuloendotheliosis (rev), avian leukosis virus (alv), and chicken infectious anemia virus (ciav) in 480 p ... | 2018 | 29509913 |