Publications
| Title | Abstract | Year Filter | PMID(sorted ascending) Filter |
|---|
| interactions of the exchange inhibitory peptide with na-ca exchange in bovine cardiac sarcolemmal vesicles and ferret red cells. | the na-ca exchange inhibitory peptide (xip), which corresponds to residues 251-270 of the na-ca exchange protein, specifically inhibits exchange activity (li, z., nicoll, d. a, collins, a., hilgemann, d. w., filoteo, a. g., penniston, j. t., weiss, j. n., tomich, j. m., and philipson, k. d. (1991) j. biol. chem. 266, 1014-1020). we have found that xip decreased na+i-dependent ca2+ uptake to 46 and 20% of control in mixed and inside-out bovine sarcolemmal (sl) vesicles, respectively, and to 22% o ... | 1992 | 1517221 |
| jaw-muscle activity in ferrets, mustela putorius furo. | electromyographical (emg) activity was recorded bilaterally from the masseter and temporalis muscles of alert ferrets (mustela putorius furo) during mastication and crushing. electromyographic activity was also recorded during biting while a bite-force transducer placed between the carnassial teeth registered forces ranging from 1.5 to 48.8 n. linear regression analysis demonstrates that temporalis and masseter emg activity are linearly related to bite force. electromyographic activity from the ... | 1992 | 1518073 |
| nicotine increases ciliary beat frequency by a direct effect on respiratory cilia. | we studied the direct effects of nicotine on the ciliary beat frequency (cbf) undisturbed by interference from mucus secretion by using epithelial strips from ferret tracheae which contain no goblet cells and, because the glands were left behind in the submucosa, no gland tissue either. strips were studied in a chamber perfused with medium m-199 at 37 degrees c at a perfusion rate of 1.6 ml min-1 using a perfusion pump (braun, melsungen). cbf was determined photometrically, the signal being subj ... | 1992 | 1521039 |
| induced periapical lesions in ferret canines: histologic and radiographic evaluation. | ferrets have been utilized in endodontic research to study periapical responses. however, various aspects of induction and healing of periapical pathosis in ferrets are unclear. this study evaluated the radiographic and histopathologic features of induced periapical lesions. periapical pathosis was consistently produced in 8 canines of 2 ferrets by extirpating the pulp, leaving the cavities open for a week, then sealing for 12 weeks. the resulting lesions were evaluated radiographically every tw ... | 1992 | 1521506 |
| pulp response to bases and cavity depths. | in cavities of ferret canines, preparation depth and bases were compared as to their effect on odontoblasts and to rate of dentin formation. these were measured by injecting 3h-proline at 0, 20 and 40 days post-preparation. odontoblast activity was determined by label density in each band; inter-band distances indicated the amount of dentin formed. correlations were by pearson's coefficient. the following were determined: 1) cavity depth (remaining dentin thickness) was the major factor in odont ... | 1992 | 1524748 |
| responses of sagittally aligned purkinje cells during perturbed locomotion: synchronous activation of climbing fiber inputs. | 1. these experiments were performed to test the hypothesis that climbing fiber inputs to sagittally aligned purkinje cells located in a single folium are activated synchronously in response to a perturbation of the step cycle that interrupts the trajectory of the ipsilateral forelimb. 2. the experiments were performed in acutely decerebrate ferrets capable of walking spontaneously on a moving treadmill. a multiple single-unit recording technique was employed utilizing a fixed array of five sagit ... | 1992 | 1527576 |
| visual projections routed to the auditory pathway in ferrets: receptive fields of visual neurons in primary auditory cortex. | how does cortex that normally processes inputs from one sensory modality respond when provided with input from a different modality? we have addressed such a question with an experimental preparation in which retinal input is routed to the auditory pathway in ferrets. following neonatal surgical manipulations, a specific population of retinal ganglion cells is induced to innervate the auditory thalamus and provides visual input to cells in auditory cortex (sur et al., 1988). we have now examined ... | 1992 | 1527604 |
| novel 5-ht3 antagonists. isoquinolinones and 3-aryl-2-pyridones. | synthesis and pharmacological evaluation of a series of 1,2-dihydro-1-[(5-methyl-1-imidazol-4-yl)methyl]-2-oxopyridine 5-ht3 antagonists are described. the key pharmacophoric elements were defined as a basic nitrogen, a linking group capable of hydrogen bonding interactions, and an aromatic moiety. 1,2-dihydro-2-oxopyridine moiety could be a good linking group because of its nicely planar structure. the steric limitations of the aromatic moiety were investigated by x-ray analysis and computer an ... | 1992 | 1527780 |
| 'reverse use-dependent' effects of 4-aminopyridine on the transient outward potassium current in ferret right ventricular myocytes. | 1992 | 1529768 | |
| mr lymphography with iron oxide compound ami-227: studies in ferrets with filariasis. | the purpose of this study was to assess the mr lymphographic potential of ami-227 to reduce the signal intensity of hyperplastic inflammatory lymph nodes by using ferrets with filariasis as the animal model. both interstitial and iv modes of administration were studied. | 1992 | 1529857 |
| dat-582, a novel serotonin3 receptor antagonist, is a potent and long-lasting antiemetic agent in the ferret and dog. | the antiemetic effects of a novel serotonin3 receptor antagonist, dat-582 [(6r)-(-)-n-[1-methyl-4-(3-methylbenzyl)hexahydro-1h-1,4- diazepin-6-yl]-1h-indazole-3-carboxamide dihydrochloride] were compared with those of the existing serotonin3 receptor antagonists, ondansetron and granisetron, in experimental animals. in ferrets, dat-582 (0.003-0.1 mg/kg i.v. twice) dose-relatedly prolonged the latency to the first emetic episode and decreased the number of emetic episodes induced by cisplatin (10 ... | 1992 | 1532032 |
| activation of two types of fibres in ferret, mustela putorius furo, cremaster muscle. | some contractile, histochemical, morphological and electrophysiological properties of ferret, mustela putorius furo, cremaster muscle have been estimated. histochemical fibre typing revealed the presence of two types of fibres (type i 66.2%, type ii 33.8%). morphometry performed on atpase-stained transverse sections showed that type i was composed of a large amount (40%) of small (less than 1400 microns2) cells. in mammalian ringer two groups of fibres could be recognized on the basis of the val ... | 1992 | 1534331 |
| effect of haemodynamic pressure overload of the adult ferret right ventricle on inotropic responsiveness to external calcium and rest periods. | the inotropic effects of external calcium concentration ([ca2+]o] and rest periods have been compared in papillary muscles isolated from control (n = 4) and pressure-overloaded right (n = 5) ventricles of adult ferrets. hypertrophy was induced by pulmonary artery clipping for 30-45 days. under control conditions (3 mm [ca2+]o, 0.1 hz), the isometric twitch force of hypertrophied muscles was decreased by 75%, time to peak was increased by 30% and time to half-relaxation was increased by 50% compa ... | 1992 | 1535435 |
| endogenous arachidonic acid metabolism by calcium ionophore stimulated ferret lungs. effect of age, hypoxia. | we have studied the metabolism of endogenous arachidonic acid by isolated perfused lungs of ferrets when stimulated with calcium ionophore a23187 at two ages, neonatal (2- to 3-week-old) and adult (greater than 6 months). we have also determined the effect of hypoxia on lung metabolism of arachidonic acid in the two age groups. lungs were perfused with kreb's bicarbonate buffer in a recirculating system and eicosanoid production was stimulated by addition of a23187 (5 microm). eicosanoids produc ... | 1992 | 1538590 |
| proteoglycan secretory components of surface epithelial cells in postnatal ferret trachea. | 1992 | 1541184 | |
| effects of endothelin-1 on tracheal submucosal gland secretion and epithelial function in the ferret. | 1992 | 1541210 | |
| pituitary adenylate cyclase activating peptide: a novel vasoactive intestinal peptide-like neuropeptide in the gut. | pituitary adenylate cyclase activating peptide (pacap) is a vasoactive intestinal peptide (vip)-like hypothalamic peptide occurring in two forms, pacap-27 and the c-terminally extended pacap-38. the predicted rat and human pacap sequence is identical to the isolated ovine one. in the present study, the occurrence and distribution of pacap-like peptides were examined in the gut of several species by immunocytochemistry and immunochemistry using an antibody raised against pacap-27. pacap-like immu ... | 1992 | 1542417 |
| distemper vaccination in ferrets. | 1992 | 1546441 | |
| mouse model for pneumocystis carinii pneumonia that uses natural transmission to initiate infection. | animal models for pneumocystis carinii, for the most part, have been limited to immunosuppressed rats and ferrets, while a dependable mouse model has been more difficult to develop. a p. carinii mouse model has now been established with several strains of mice, including c3heb/fej, c3hen, balb/c, dba/2n, and balb/c nu/nu (athymic). in lieu of using invasive methods for initiating p. carinii infections, mice harboring p. carinii transmitted the disease to mice without latent infection via short-t ... | 1992 | 1548065 |
| development of high-affinity 5-ht3 receptor antagonists. 2. two novel tricyclic benzamides. | two new classes of potent 5-ht3 agents have been developed and examined as inhibitors of cytotoxic drug induced emesis in the ferret and dog. the absolute configuration of the most active molecules 10 and 18 have been determined by x-ray crystallography. these two compounds are more potent than known 5-ht3 receptor antagonists both in vivo and in vitro in blocking 5-ht3 receptor activation and preventing chemotherapeutic induced emesis. compared with 5-ht3 antagonists, such as gr 38032f, zacopri ... | 1992 | 1548679 |
| [effects of magnesium on early post-depolarization and trigger activity induced by cesium on purkinje fibers in ferrets]. | the effects of magnesium (mg) on afterdepolarisations and cesium-induced activity were studied in 15 preparations of ferret purkinje fibres. when the perfusion medium was enriched with mg to concentrations of 5 mm, the duration of the action potentials stopped increasing and the diastolic membrane potential was stabilised despite persistent exposure to cesium. a suppressor effect of mg on the high and low voltage early afterdepolarisations was observed which was significant at 2.2 mm (p less tha ... | 1992 | 1550438 |
| endocardial endothelium modulates myofilament ca2+ responsiveness in aequorin-loaded ferret myocardium. | the influence of selective removal of the endocardial endothelium (by a 1-second exposure to the detergent triton x-100, 0.5%) on myofilament ca2+ responsiveness and intracellular ca2+ transients was studied in ferret papillary muscles loaded with the ca(2+)-regulated bioluminescent indicator aequorin. the removal of endocardial endothelium produced three major effects: 1) a decrease in peak developed tension and an early onset in isometric relaxation without corresponding changes in the intrace ... | 1992 | 1551201 |
| role of transsarcolemmal ca2+ entry in the negative inotropic effect of nitrous oxide in isolated ferret myocardium. | the purpose of this study was to investigate the effects of nitrous oxide (n2o) on transsarcolemmal calcium influx in isolated ferret right ventricular myocardium. using a range of loading conditions, papillary muscles were equilibrated in 50% nitrogen (n2) or 50% n2o in oxygen in the presence and absence of ryanodine, a specific inhibitor of calcium release from the sarcoplasmic reticulum. after equilibration in 50% n2o or 50% n2 in oxygen, peak developed force, peak isotonic shortening, and ma ... | 1992 | 1554125 |
| comparative vaginal cytology of the estrous cycle of black-footed ferrets (mustela nigripes), siberian polecats (m. eversmanni), and domestic ferrets (m. putorius furo). | vaginal cytology and vulva size were used to characterize the reproductive cycle of female black-footed ferrets (mustela nigripes), siberian polecats (m. eversmanni), and domestic ferrets (m. putorius furo). emphasis was on black-footed ferrets because of the need to breed these critically endangered animals and on siberian polecats because of the close taxonomic relationship to black-footed ferrets. vaginal cytology of the 3 species of ferret is similar. proestrus was characterized by an increa ... | 1992 | 1554767 |
| malignant lymphoma in ferrets: clinical and pathological findings in 19 cases. | the clinical and pathological findings in 19 ferrets (mustela putorius furo) with malignant lymphoma are reviewed. peripubescent ferrets had rapidly progressive stage iv high grade immunoblastic or small non-cleaved cell lymphoma. adult ferrets had stage ii or iv low grade diffuse small lymphocytic (dsl) lymphoma, stage iv high grade small non-cleaved cell lymphoma, or stage iv high grade immunoblastic polymorphous (ibp) lymphoma. three ferrets had concurrent ibp and dsl lymphoma involving diffe ... | 1992 | 1556256 |
| eosinophilic gastroenteritis with splendore-hoeppli material in the ferret (mustela putorius furo). | eosinophilic gastroenteritis, focal or diffuse with eosinophilic infiltrations of the stomach or intestine, has been described in human beings, cats, dogs, and horses. in this paper, we describe infiltration of the gastrointestinal tract with eosinophils accompanied by a circulating eosinophilia in six ferrets (mustela putorius furo). clinical signs included chronic weight loss, anorexia, and diarrhea. the small intestines from five ferrets had diffuse infiltrates of eosinophils. this resulted i ... | 1992 | 1557863 |
| contraction of single vascular smooth muscle cells by phenylephrine at constant [ca2+]i. | the mechanism of alpha-adrenergic agonist-mediated force generation was investigated in single hyperpermeable vascular smooth muscle cells. by use of a previously described method, force was recorded from individual ferret aortic cells made hyperpermeable by exposure to saponin. when the cells were clamped at pca 7, addition of protein kinase m (pkm), the constitutively active form of protein kinase c (pkc), caused a sustained increase in force, which was reversible upon addition of the pkc pseu ... | 1992 | 1558185 |
| effect of ketamine hcl on norepinephrine disposition in isolated ferret ventricular myocardium. | the purpose of this study was to determine if ketamine altered the release or disposition of norepinephrine at adrenergic nerve terminals in isolated ferret myocardium. in superfused right ventricular strips, the effect of ketamine on norepinephrine release and uptake was determined. dihydroxyphenylglycol, the intraneuronally derived metabolite of norepinephrine, served as an index of neuronal uptake and was also measured in superfusate. pharmacological manipulation of selective aspects of adren ... | 1992 | 1560358 |
| interactions of ibuprofen with influenza infection and hyperammonemia in an animal model of reye's syndrome. | we have previously reported that a single meal of an arginine-free diet rapidly induces hyperammonemia in young ferrets and that aspirin administration in conjunction with influenza b infection and arginine-free diet results in clinical and biochemical alterations consistent with reye's syndrome. the objective of the present study was to test whether ibuprofen administration, either alone or in combination with influenza infection and arginine-free diet, produces a similar effect. two-mo-old fer ... | 1992 | 1561011 |
| distemper vaccination in ferrets. | 1992 | 1561749 | |
| sylvatic american trypanosomiasis in argentina. trypanosoma cruzi infection in mammals from the chaco forest in santiago del estero. | trypanosoma cruzi infection in sylvatic mammals of the quebracho woods of the eastern part of santiago del estero province, argentina, was studied from october 1984 to december 1987. 301 mammals of 20 different species were caught. t. cruzi, characterized biologically and biochemically, was isolated by xenodiagnosis from 23 of 72 (32%) didelphis albiventris opposums, 2/36 (5.5%) conepatus chinga skunks, and one ferret (galictis cuja). 53 opossum refuges were located and triatomine bugs were foun ... | 1992 | 1566301 |
| a ferret model of acute multifocal gastrointestinal infarction. | based on the demonstration of mural granulomatous vasculitis in crohn's disease, it was hypothesized that this vasculitis may account for the discontinuous pattern of lesions in this condition. accordingly, the present study investigated the histological changes produced by interruption of the submucosal and mucosal microcirculation in the ferret midgut. two techniques were used. first, up to 30 adjacent vasa recta were ligated using microsurgical techniques; this produced no evidence of ischemi ... | 1992 | 1568569 |
| periapical innervation of the ferret canine one year after pulpectomy. | previous studies have shown that, following removal of the dental pulp and its replacement with a filling material, the nerves in the periapical region proliferate within an area of chronic inflammation. this study examined these responses in the ferret in more detail, both quantitatively and in three dimensions, 12 months after pulpectomy which was followed by obturation with gutta percha and zinc oxide and eugenol sealer. the results were compared with the responses after three months. the bas ... | 1992 | 1573078 |
| effects of reduced external sodium concentration and multivalent cations on caffeine contractures in young ferret atrial trabeculae. | the characteristics of caffeine (1.25-80 mm) transient contractures have been examined in small atrial trabeculae (diameters 50-250 microns) isolated from young (1-1.5 months) ferret hearts. in the control medium, the half-saturation constant and the maximum contracture strength (at infinite caffeine concentration) were 37.8 +/- 10.2 mm and 0.9 +/- 0.2 kn.kg-1 (n = 11), respectively. the contractile response to caffeine was markedly enhanced following reduction of external sodium (70-0 mm). the ... | 1992 | 1581856 |
| c-terminal modifications of nonpeptide renin inhibitors: improved oral bioavailability via modification of physicochemical properties. | we describe the development of a series of soluble, potent, and bioavailable nonpeptide renin inhibitors. these inhibitors derived from a series of novel nonpeptide renin inhibitors which were recently identified in our laboratories, by alteration of the nature of the c-terminus (p2') of the molecules. introduction of basic substituents into modified hydroxyethylene dipeptide isosteres gave inhibitors with improved solubility as well as improved potency against human plasma renin. in addition, t ... | 1992 | 1588555 |
| mechanisms of intrinsic tone in ferret vascular smooth muscle. | 1. circular strips from ferret aorta were used to investigate the mechanism of the intrinsic basal tone. 2. determinations of stiffness using small sinusoidal length changes showed an abolition of both stiffness and force with cooling, but the temperature dependence of the change in active stiffness did not parallel that of force. at temperatures below 22 degrees c there appeared to be a relatively large population of attached, non-force-generating cross-bridges, indicating that separate mechani ... | 1992 | 1593466 |
| platelet-activating factor relaxes ferret tracheal smooth muscle and reduces transepithelial potential difference in vitro. | 1. the effects of platelet activating factor (paf) were examined on the smooth muscle tone, mucus volume, lysozyme and albumin outputs and potential difference (pd) across the ferret tracheal wall. 2. paf (0.1-10 microm) had no direct effect on mucus volume, lysozyme or albumin output from the ferret trachea. paf produced concentration-dependent relaxations of the tracheal smooth muscle and reductions in pd across the tracheal wall. there was no change in the histological appearance of the trach ... | 1992 | 1596685 |
| paf-induced muscarinic cholinoceptor hyperresponsiveness of ferret tracheal smooth muscle and gland secretion in vitro. | 1. the effects of exposure of the ferret trachea in vitro to platelet activating factor (paf) were examined on methacholine-induced smooth muscle contraction, mucus volume and lysozyme outputs, and albumin transport across the tracheal epithelium. 2. methacholine (0.1-30 microm) produced concentration-dependent increases in tracheal smooth muscle tone and mucus volume, lysozyme and albumin outputs from the trachea. 3. the concentration-response curves for methacholine-induced smooth muscle contr ... | 1992 | 1596686 |
| lymphatic imaging in experimental filariasis using magnetic resonance. | to evaluate acquired lymphatic abnormalities caused by filariasis, the authors examined the peripheral lymphatic system in normal ferrets and those chronically infected with brugia malayi using magnetic resonance imaging (mri). the findings were compared with previously obtained lymphangioscintigraphic (las) images in ferrets both with and without experimental filariasis. | 1992 | 1601619 |
| intracellular calcium and ventricular function. effects of nisoldipine on global ischemia in the isovolumic, coronary-perfused heart. | ischemia-induced ventricular dysfunction has been shown to be associated with increased diastolic and systolic intracellular concentrations of free, ionized calcium ([ca2+]i). the present study was designed to determine the effects of the ca2+ antagonist nisoldipine on the relationship between [ca2+]i and left ventricular contraction and relaxation during ischemia and reperfusion on a beat-to-beat basis. nine isovolumic coronary-perfused ferret hearts were made globally ischemic for 3 min and re ... | 1992 | 1602012 |
| changes in intracellular free calcium concentration during long exposures to simulated ischemia in isolated mammalian ventricular muscle. | intracellular free calcium concentration ([ca2+]i) was measured in isolated ferret ventricular papillary muscles during and after long exposures to ischemia. all experiments were performed at 37 degrees c, and the muscles were stimulated at 1 hz. ischemia was simulated by changing from superfusion with oxygenated tyrode's solution to superfusion with water-saturated gas (95% n2-5% co2), thus simultaneously stopping oxygenation and restricting the extracellular space. [ca2+]i was measured with ae ... | 1992 | 1606668 |
| rapid development of the auditory brainstem response threshold in individual ferrets. | the development of the ferret auditory system was examined using the auditory brainstem response (abr). longitudinal recordings were obtained under short-acting anaesthesia from individual animals at 4-h or 24-h intervals. particular attention was focused on the period from postnatal day (p) 26 to p32 when the ferret auditory system becomes functional. abr thresholds to click stimuli presented in a free-field were found to decline precipitously within a 4-h period during the first 24 h following ... | 1992 | 1606688 |
| pyloric adenocarcinoma in a ferret. | pyloric adenocarcinoma was diagnosed in a ferret with clinical signs of gastric distention. the development of this tumor may be related to helicobacter mustelae infection in the gastric mucosa of ferrets. pyloric adenocarcinoma has only recently been reported in ferrets and should be considered as a differential diagnosis for gastric distention in this species. | 1992 | 1607319 |
| zoonoses of house pets other than dogs, cats and birds. | in addition to dogs, cats and birds, which are the most frequent house pets, rabbits, rodents, fish and turtles are also vertebrate species that commonly share the home environment. lizards, snakes and ferrets are less common pets. these species can transmit numerous diseases, especially to children who are more likely to be in close contact with them. the author presents a general review of zoonoses and potential zoonoses transmitted by rabbits, rodents and cold blooded vertebrates. zoonoses tr ... | 1992 | 1608686 |
| effect of mebeverine hydrochloride on jejunal motility and epithelial transport in the anesthetized ferret. | previous in vitro and in vivo studies demonstrate that mebeverine, administered to isolated smooth muscle preparations or given intravenously, (i.v.), acts as an antispasmodic agent and may be useful in treating intestinal hypermotility. whether mebeverine affects intestinal mucosal transport is, however, unknown. the aim of the present study was to characterize the effect of mebeverine on both small intestinal motor activity and electrogenic epithelial transport in the urethane anesthetized fer ... | 1992 | 1612107 |
| an ultrastructural study of helicobacter mustelae and evidence of a specific association with gastric mucosa. | the ultrastructure of helicobacter mustelae, a natural inhabitant of the ferret stomach, has been studied and compared with the human gastroduodenal pathogen h. pylori. h. mustelae is a short, slightly curved rod, 2 microns x 0.5 micron, with four or more sheathed flagella. the most common flagellar configuration is a single flagellum at one terminus, bipolar arrangement at the other end and a lateral flagellum. dense inclusion bodies were observed below the flagellar insertion sites. it is sugg ... | 1992 | 1613782 |
| arachidonic acid increases cholinergic secretory responsiveness of ferret tracheal glands. | the purpose of this study was to determine if arachidonic acid could alter ferret tracheal gland secretory responsiveness to a cholinergic agonist. we prepared glandular explants and incubated the explants in medium containing [3h]glucosamine. secretory responsiveness was expressed as the percent change in basal secretion of acid-precipitable [3h]glucosamine-labeled glycoconjugates induced by the addition of agonist with and without arachidonic acid [mean +/- se (n)]. addition of 10(-3) m arachi ... | 1992 | 1616053 |
| effects of endothelin, platelet activating factor and thromboxane a2 in ferret lungs. | we have compared the effects of three vasoactive agents, endothelin, platelet activating factor and thromboxane a2 analogue, u 46,619, in the pulmonary circulation of ferrets. lungs of nine adult ferrets, body weight 1.06 +/- 0.27 kg, were isolated and perfused with sheep red blood cells suspended in kreb's solution with 2 g% dextran 70 (hematocrit 33 +/- 6%), under conditions of constant flow in zone 3. endothelin-1 (et: 0.1-1.35 micrograms/kg), platelet activating factor (paf: 0.5-5.5 microgra ... | 1992 | 1626132 |
| subacute toxicity and maximum tolerable dose of sertaconazole in repeated administration studies. | 28-day oral and dermal subacute toxicity studies of 7-chloro-3-[1-(2,4-dichlorophenyl)-2-(1h-imidazol-1-yl) ethoxy-methyl] benzo [b] thiophene (sertaconazole, fi-7045, cas 99592-32-2), were carried out. the oral studies included the evaluation of subacute toxicity in rat (dose levels of 50, 150 and 300 mg/kg) and maximum tolerable dose in repeated administration in ferrets (consecutive dose levels in accordance with a geometric progression of 50, 75, 112.5, 168 and 250 mg/kg), which were the ani ... | 1992 | 1627193 |
| chronic toxicity studies of sertaconazole after oral administration to rats and ferrets. | six-month chronic oral toxicity studies of 7-chloro-3-[1-(2, 4-dichlorophenyl)-2-(1h-imidazol-1-yl)ethoxy-methyl] benzo[b]thiophene (sertaconazole, fi-7045, cas 99592-32-2) were carried out in rats and ferrets. the dose levels used were 50, 150 and 300 mg/kg in rats and 50, 150 and 250 mg/kg in ferrets. there was no mortality associated with the drug in either of the two species. the results obtained show that the toxic effects may be summarized as a smaller body weight increase in rats at 150 a ... | 1992 | 1627194 |
| midline and lateral field sound localization in the ferret (mustela putorius): contribution of the superior olivary complex. | 1. the ability of ferrets to localize sound in space was determined before and after unilateral or bilateral lesions of the superior olivary complex (soc). lesions were made by pressure injection of kainic acid into the soc through a stereotaxically positioned glass micropipette. the lesions destroyed the cell bodies in the superior olive without disrupting fibers of passage in the trapezoid body or other pathways in the auditory brain stem. the integrity of fibers was demonstrated by protargol ... | 1992 | 1629768 |
| visual callosal projections in the adult ferret. | the laminar and tangential organization of visual callosal projections of areas 17 and 18 were investigated in the adult ferret, using histochemical methods to visualize axonally transported horseradish peroxidase (hrp). normal adult ferrets were given injections of hrp throughout one visual cortex or had gelfoam soaked in hrp applied to the transected corpus callosum. the ferret callosal cell distribution has a greater tangential extent in area 18 than in area 17. in addition, the radial organi ... | 1992 | 1633130 |
| action potential duration and endocardial modulation of myocardial contraction in the ferret. | endocardial endothelium releases substances which modulate myocardial contraction. selective endocardial removal abbreviates contraction by removing a contraction prolonging substance "endocardin". the aim of the study was to investigate whether changes in action potential duration underlie these contractile effects. | 1992 | 1638571 |
| strain rate effects on tensile failure properties of the common carotid artery and jugular veins of ferrets. | we have recently reported the insensitivity of tensile failure properties of human cerebral bridging veins to strain rate. due to data scattering, however, concerns remain regarding this finding. to pursue the issue further, the common carotid arteries and external and internal jugular veins from seven ferrets were stretched longitudinally in vitro at either a low strain rate of 0.2-2.0 s-1 or a high rate of approximately 200 s-1. the ultimate stretch ratios and loads were found to be independen ... | 1992 | 1639836 |
| parvovirus-associated syndrome (aleutian disease) in two ferrets. | there is a paucity of information regarding natural aleutian disease, caused by a parvovirus in ferrets. with the increasing popularity of ferrets as household pets and laboratory animals, and with the advent of a usda-approved rabies vaccine, the occurrence and the etiopathogenesis of naturally acquired diseases in ferrets needs to be documented. we present the clinical and laboratory findings associated with aleutian disease in 2 domestic ferrets, one with the chronic wasting form of the disea ... | 1992 | 1644626 |
| okadaic acid, a protein phosphatase inhibitor, increases the calcium transients in isolated ferret ventricular muscle. | okadaic acid is a protein phosphatase inhibitor which has been found to produce a marked positive inotropic effect in isolated cardiac muscle. using aequorin-injected ferret papillary muscles, we demonstrate that the increase in tension seen with okadaic acid is accompanied by a simultaneous increase in the amplitude of the calcium transients. by comparison with the effects of changing the extracellular calcium concentration, it is shown that the increase in calcium transient amplitude can accou ... | 1991 | 1647801 |
| the effects of ph changes on human and ferret detrusor muscle function. | 1. the effects of altering extracellular ph on the electrically evoked contractions of ferret and human bladder (detrusor) smooth muscle have been investigated. ph was varied by changing superfusate pco2 or nahco3 concentration. acidosis increased force when superfusate pco2 was raised but decreased force when the nahco3 concentration was reduced. 2. intracellular ph (phi) in isolated ferret detrusor cells was measured separately by epifluorescence microscopy. extracellular ph changes caused by ... | 1991 | 1653318 |
| the antiemetic profile of y-25130, a new selective 5-ht3 receptor antagonist. | y-25130( (+/-)n-(1-azabicyclo[2.2.2]oct-3-yl)-6-chloro-4-methyl-3-oxo-3,4-dihydro - 2h-1,4-benzoxazine-8-carboxamide hydrochloride) is a potent and selective 5-ht3 receptor antagonist free of dopamine receptor blocking activity. this compound was effective against emesis induced in animals by cytotoxic drugs or by total body x-radiation. when given prophylactically, the doses required to completely inhibit cisplatin-induced emesis in dogs and doxorubicin and cyclophosphamide-induced emesis in fe ... | 1991 | 1654255 |
| spinal dracunculiasis in an experimentally infected ferret. | 1991 | 1658452 | |
| in vitro cytopathogenicity and in vivo virulence of two strains of canine parainfluenza virus. | in vivo and in vitro properties of two strains of canine parainfluenza virus (cpiv) were investigated. one strain, designated cpiv(+), induced syncytial giant cell formation and cytolysis in vitro, whereas the second strain, cpiv(-), caused only a mild strand-forming cytopathic effect with few, small syncytial giant cells. vero cells infected with cpiv(+) or cpiv(-) were 100% positive for cpiv antigen as determined by immunofluorescent staining; however, 100% of cpiv(+) and less than 10% of cpiv ... | 1991 | 1659020 |
| the actions of fentanyl to inhibit drug-induced emesis. | the ability of fentanyl to inhibit drug-induced emesis was investigated in the ferret. initial studies established that morphine, in small doses (0.025-0.5 mg/kg s.c.), induced emesis in the ferret that decreased at the larger doses of 1 and 2 mg/kg (s.c.). fentanyl (10-80 micrograms/kg s.c.) failed to induce emesis but in this dose range prevented the emesis induced by morphine (0.5 mg/kg s.c.), apomorphine (0.25 mg/kg s.c.), copper sulphate (100 mg/kg intragastric) and cisplatin (10 mg/kg i.v. ... | 1991 | 1661861 |
| preliminary evidence for the involvement of the putative 5-ht4 receptor in zacopride- and copper sulphate-induced vomiting in the ferret. | previous studies of the mechanism of zacopride-induced emesis in ferrets have concluded that it is mediated predominantly by an antagonist effect on 5-ht3 receptors although the possibility of a contribution from an agonist effect at 5-ht4 receptors was not excluded. this study shows that zacopride (200 micrograms/kg p.o.)-induced emesis can be blocked by a 'high dose' (1000 micrograms/kg) of ics205930 but not by a low dose (100 micrograms/kg) or by 'high doses' (1000 micrograms/kg) of another m ... | 1991 | 1663456 |
| intranasal infection of ferrets (mustela putorius furo) with canine parainfluenza virus. | immunocompetent and cyclophosphamide-immunosuppressed ferrets were intranasally infected with canine parainfluenza virus (cpiv) and observed for clinical signs, histopathologic lesions, the immunocytochemical demonstration of cpiv antigen in the respiratory tract and scanning electron microscopic alterations of the tracheal epithelium until 36 days post infection (p.i.). in both groups, clinical signs were minimal, restricted to the upper respiratory tract and consisted of cough elicited by trac ... | 1991 | 1663681 |
| organisation of the visceral solitary tract nucleus in the ferret as defined by the distribution of choline acetyltransferase and nerve growth factor receptor immunoreactivity. | the cholinergic innervation of the visceral component of the nucleus of the solitary tract in the ferret was investigated by using choline acetyltransferase immunocytochemistry. the subdivisions of the ferret solitary tract nucleus as defined by nissl architectonics were found to correspond to most of those previously assigned to the cat solitary tract nucleus. the subnuclei of the ferret solitary tract nucleus were also outlined by using immunohistochemical and histochemical methods to stain fo ... | 1991 | 1667621 |
| cisplatin-evoked induction of c-fos protein in the brainstem of the ferret: the effect of cervical vagotomy and the anti-emetic 5-ht3 receptor antagonist granisetron (brl 43694). | we have monitored the expression of c-fos protein in the medulla oblongata of the ferret, using immunocytochemistry, to identify the brainstem pathways involved in the mediation of nausea and vomiting caused by the antineoplastic drug cisplatin. cisplatin administration resulted in c-fos-like immunoreactivity (fli) in the area postrema, the nucleus of the solitary tract, and in scattered cells within the ependymal lining of the fourth ventricle. unilateral cervical vagotomy greatly reduced fli i ... | 1991 | 1668810 |
| effect of capsaicin on nasal secretion in anesthetized ferrets. | in urethan-anesthetized ferrets, we investigated the nasal response to capsaicin infused via a catheter inserted retrogradely into the lingual artery. capsaicin dose-dependently increased fluid output from the nose (nasal fluid output) and the lateral nasal gland (glandular fluid output). the secretory response to capsaicin (80 nmol/kg ia) was completely blocked by atropine and hexamethonium, indicating that a cholinergic reflex mediates capsaicin-induced nasal hypersecretion in this model. the ... | 1991 | 1672688 |
| cholinergic input to dopaminergic neurons in the substantia nigra: a double immunocytochemical study. | in order to determine whether the cholinergic fibres that innervate the substantia nigra make synaptic contact with dopaminergic neurons of the substantia nigra pars compacta, a double immunocytochemical study was carried out in the rat and ferret. sections of perfusion-fixed mesencephalon were incubated first to reveal choline acetyltransferase immunoreactivity to label the cholinergic terminals and then tyrosine hydroxylase immunoreactivity to label the dopaminergic neurons. each antigen was l ... | 1991 | 1678502 |
| receptor-mediated camp production in adult and infant ferret tracheal epithelium. | tracheal epithelial cells obtained from adult and infant ferrets were grown in primary culture in vitro. cells from adult animals grew readily, and many ciliated cells were observed in the cultures. successful cultures were derived from infant animals, but cell number in infant and adult cultures began to decrease after 6 d. receptor-mediated activation of adenylate cyclase was determined by incubating monolayers of adult or neonatal cells with beta-adrenergic agonists, prostaglandin e2 (pge2) a ... | 1991 | 1679920 |
| early development of the nucleus basalis-cortical projection but late expression of its cholinergic function. | the aim of this study was to examine the development of the basalocortical pathway by using choline acetyltransferase and nerve growth factor receptor immunocytochemistry, acetylcholinesterase histochemistry and retrograde axonal transport. the observations were made in the ferret because in this species brain development occurs over a much more protracted period than in the rat. staining for choline acetyltransferase immunoreactivity in the brain was minimal before birth. adult levels of staini ... | 1991 | 1682850 |
| evidence that vasoactive intestinal peptide (vip) is an inhibitory transmitter in the ferret gastric corpus. | 1991 | 1686329 | |
| mechanism for the emetic side effect of xanthine bronchodilators. | the usefulness of xanthine bronchodilators in the treatment of asthma is often limited by the side effects of nausea and vomiting. we investigated the mechanism of emesis induced by xanthines, by examining the roles of phosphodiesterase (pde) inhibition and adenosine antagonism. theophylline, enprofylline, 8-phenyltheophylline and isobutylmethylxanthine (ibmx), as well as vehicle, were given to ferrets at doses ranging from 0.1 to 150 mg/kg i.p. the potencies of these compounds in producing emet ... | 1990 | 1689799 |
| peptide-containing nerve fibers in the circumvallate papillae. | the occurrence and distribution of an array of neuropeptides and dopamine-beta-hydroxylase in the circumvallate papillae of monkey, pig, cow, ferret, cat, rat and mouse was studied by immunocytochemistry. the animals were chosen to represent species with different diets. substance p/neurokinin a- and calcitonin gene-related peptide-containing fibers were numerous in the circumvallate papillae of all animals examined, with the highest frequency in monkey, pig, cow, rat and mouse; in ferret and ca ... | 1990 | 1691515 |
| effects of substance p and vasoactive intestinal polypeptide on contractile activity and epithelial transport in the ferret jejunum. | previous studies in the ferret demonstrated that vagal nerve stimulation induced an atropine-resistant water secretion. substance p and vasoactive intestinal polypeptide are possible mediators of this secretory response. the objectives of this study were to investigate the in vivo effects of substance p and vasoactive intestinal polypeptide on the jejunal musculature and epithelium. substance p caused an increase in jejunal motility, water secretion, and transmural potential difference. choliner ... | 1990 | 1692548 |
| auditory brainstem of the ferret: bilateral cochlear lesions in infancy do not affect the number of neurons projecting from the cochlear nucleus to the inferior colliculus. | unilateral cochlear removal in infancy produces a number of changes in the structure and physiology of the central auditory system. to test the role that interaural competition plays in this plasticity, ferrets were reared with bilateral cochlear removals from the fourth postnatal week; before the time of the normal onset of auditory function. the totality of the removals was confirmed using brainstem response audiometry and cochlear histology. following 3-month survival, the animals were inject ... | 1990 | 1694743 |
| positive inotropy contributes to the hemodynamic mechanism of action of flosequinan (bts 49465) in the intact dog. | flosequinan (bts 49465) is a putative, selective direct-acting balanced vasodilator currently undergoing evaluation for the treatment of congestive heart failure (chf) and hypertension. we examined the pharmacologic action of flosequinan and compared it to milrinone and nitroprusside (snp). in ferret papillary muscle, in vitro, flosequinan (1-100 microm) increased the rate of force development up to 116%. the effect was not blocked by nadolol (10 microm). flosequinan was less effective than milr ... | 1990 | 1694912 |
| [stimulation of mucous glands of the respiratory tract by neuropeptides: comparison of exogenous administration and endogenous liberation]. | exogenous substance p is a powerful stimulant of tracheal gland secretion but the contribution of endogenous neuropeptides to neurogenic gland secretion is unknown. using the ussing chamber technique, we measured the secretion of radiolabeled macromolecules from submucosal glands in the ferret. neurokinins caused gland secretion through a neurokinin-1 (nk-1) receptor. gland secretion caused by electric field stimulation of postganglionic nerve endings was not inhibited by a substance p antagonis ... | 1990 | 1695001 |
| modulation of ca2+ transients and contractile properties by beta-adrenoceptor stimulation in ferret ventricular muscles. | 1. the mechanism of modulation of ca2+ transients and contraction by beta-adrenoceptor stimulation was studied in ferret ventricular muscles using aequorin to measure intracellular ca2+. 2. peaks of tension and light transients were increased by isoprenaline (10(-9) - 5 x 10(-7) m) which also abbreviated their time courses. 3. time-to-peak tension was significantly shortened by 5 x 10(-9) m-isoprenaline and time-to-peak light was abbreviated by 10(-9) m-isoprenaline. 4. the time for the light to ... | 1990 | 1696985 |
| excitation-contraction coupling model to estimate the recirculating fraction of activator calcium in intact cardiac muscle. | potentiated contractions were evoked with rapid pace pause maneuver in 14 length-clamped ferret papillary muscles paced 12 times/min at 25 degrees c. at 1.25 mm [ca2+]o the average steady-state force was 2.94 +/- 1.08 g/mm2 and the potentiated contraction averaged 10.96 +/- 1.61 g/mm2. at 5.0 mm [ca2+]o the steady-state force increased to 6.18 +/- 1.23 g/mm2 and the potentiated contraction averaged 12.08 +/- 1.15 g/mm2. under the conditions of these experiments the potentiated contraction obtain ... | 1990 | 1697217 |
| use of dna restriction endonuclease digest and ribosomal rna gene probe patterns to fingerprint helicobacter pylori and helicobacter mustelae isolated from human and animal hosts. | variation amongst strains of helicobacter pylori and helicobacter mustelae was examined by dna restriction endonuclease digestion and rrna gene patterns generated using a non-radioactive probe. chromosomal dna was extracted from 30 cultures of h. pylori from human, rhesus monkey and pig gastric mucosa, and from three h. mustelae isolates from ferret gastric mucosa. dna fingerprinting with hae iii and hind iii showed h. mustelae was relatively homogeneous but revealed genomic heterogeneity within ... | 1990 | 1698260 |
| development of the lateral geniculate nucleus: interactions between retinal afferent, cytoarchitectonic, and glial cell process lamination in ferrets and tree shrews. | we have studied the relationship of retinal afferents, glial cell processes, and neuronal cytoarchitectonics in the lateral geniculate nucleus (lgn) of two species: tree shrews (tupaia belangeri) and ferrets (mustela putoris). both species are relatively immature at birth, allowing the development of these features to be studied in the perinatal period. retinal afferents, visualized by intraocular injection of a wheat germ agglutinin/horseradish peroxidase conjugate (wga-hrp), are apparently the ... | 1990 | 1698826 |
| visual projections induced into the auditory pathway of ferrets. i. novel inputs to primary auditory cortex (ai) from the lp/pulvinar complex and the topography of the mgn-ai projection. | the organization of cortical circuitry responsible for processing sensory information is a subject of intense examination. however, it is not known whether cortical cells in different sensory cortices process information in a way that is specific to the modality of their input, or whether there are commonalities in processing circuitry across different cortices. in our laboratory, this question has been investigated at the level of the geniculocortical pathway by routing information of one senso ... | 1990 | 1698829 |
| the topographic relationship between shifting binocular maps in the developing dorsal lateral geniculate nucleus. | the major mammalian subcortical visual structures receive topographically ordered projections from both eyes. in the adult dorsal lateral geniculate nucleus (dlgn) each projection terminates in separate restricted regions of the nucleus. this pattern is different during development. initially in ferrets the projections from each eye to the dlgn overlap throughout this structure. although the projections do not occupy regions that are appropriate given the adult pattern, they are both retinotopic ... | 1990 | 1704850 |
| bleomycin chemotherapy for metastatic squamous cell carcinoma in a ferret. | bleomycin, an antitumor antibiotic, was effective in temporarily reducing the size of a metastatic squamous cell carcinoma in a ferret. the tumor had recurred after previous excision and had metastasized to the right submandibular lymph node. the ferret was treated without effect at a dosage of 10 u/m2, sc, once a week. the dosage was increased to 20 u/m2 once a week, and reduction of tumor size was observed. | 1991 | 1704878 |
| somatodendritic morphology of on- and off-cells in the rostral ventromedial medulla. | the rostral ventromedial medulla (rvm) contains two classes of physiologically defined neurons, on-cells and off-cells, that are implicated in nociceptive modulation. in a continuing effort to detail the neural circuitry that underlies the activity of these two distinct neuronal types, the somatodendritic morphology of on- and off-cells was studied in the cat, rat, and ferret. in lightly anesthetized animals, on-cells increased and off-cells decreased their discharge rate during a withdrawal ref ... | 1990 | 1706357 |
| emesis-related biochemical and histopathological changes induced by cisplatin in the ferret. | cisplatin is an effective antineoplastic agent that causes severe vomiting due to unknown mechanism. the ferret, an animal model useful in the determination of emetic activity, was used to clarify the emesis-related biochemical and histopathological changes that were induced by cisplatin. cisplatin (5 to 10 mg/kg) was administered intraperitoneally and a 7-10 mg/kg i.p. dose evoked dose-dependent emesis in the ferret. almost all cisplatin-vomiting episodes occurred within a 6 hour observation pe ... | 1990 | 1707101 |
| tachykinin receptors mediating airway macromolecular secretion. | three tachykinin receptor types, termed nk1, nk2, and nk3, can be distinguished by the relative potency of various peptides in eliciting tissue responses. airway macromolecular secretion is stimulated by the tachykinin substance p (sp). the purposes of this study were to determine the tachykinin receptor subtype responsible for this stimulation, and to examine the possible involvement of other neurotransmitters in mediating this effect. ferret tracheal explants maintained in organ culture were l ... | 1991 | 1708071 |
| sensory innervation of the mystacial pad fur of the ferret. | the guard and vellus hairs on the muzzles of many mammalian species possess a complex sensory innervation. the observation in the primate that the sources of the endings may be segregated by afferent type to separate terminal nerve branches prompted us to examine the innervation of the mystacial fur on the ferret muzzle. sections were prepared with reduced silver techniques and serially reconstructed for analysis. the types and orientations of sensory endings in the ferret are similar to those d ... | 1991 | 1708478 |
| effects of 8-bromo-cyclic gmp on contraction and on inotropic response of ferret cardiac muscle. | the effects of guanosine 3':5'-cyclic monophosphate (cgmp) on cardiac contraction are not established. using isolated electrically-stimulated ferret papillary muscle at 29 degrees c, 2.0 mm calcium we investigated the effects of 8-bromo-cgmp on (a) basal contraction for comparison with the effects of reduction in extracellular calcium or of reduction in resting muscle length; (b) contraction of preparations stimulated by isoprenaline, the dihydropyridine calcium agonist bay k8644 or post-extrasy ... | 1991 | 1709973 |
| the effects of calcitonin gene-related peptide on submucosal gland secretion and epithelial albumin transport in the ferret trachea in vitro. | 1. we have examined the effect of calcitonin gene-related peptide (cgrp) on basal mucus volume, lysozyme and albumin outputs from the ferret whole trachea in vitro, and on the outputs produced by methacholine and substance p (sp). we have also examined the effect of inhibiting neutral enkephalinase with thiorphan on the responses to cgrp. 2. cgrp (1-100 nm) produced small concentration-dependent increases in basal mucus volume, lysozyme and albumin outputs. these effect of cgrp were enhanced by ... | 1991 | 1710527 |
| characterisation of the urease from helicobacter pylori and comparison with the ureases from related spiral gastric bacteria. | the urease enzyme of helicobacter pylori was partially purified from whole cell extracts and found to have a molecular weight of 484 +/- 12 kda. ten monoclonal antibodies (mabs) were produced against four different epitopes of the native enzyme. these mabs also recognised the ureases of h. pylori-like organisms isolated from monkeys and pigs and the h. mustelae urease from ferrets. the urease enzymes of each of these organisms were found to be of the same molecular weight. the urease enzyme of h ... | 1991 | 1711875 |
| efficacy of a monoclonal antibody (moab 60.3) in reducing myocardial injury resulting from ischemia/reperfusion in the ferret. | the myocardial salvage efficacy of a monoclonal antibody (moab 60.3) directed at the cdw 18 membrane antigen complex essential for normal neutrophil function was evaluated in a ferret occlusion/reperfusion model. when infused i.v. over a 10-min interval beginning at the 45th minute of a 90-min occlusion at a fixed dose of 2 mg/kg, the antibody afforded 33 and 45% reductions in infarct size following reperfusion intervals of 6 and 24 h, respectively. administration of that same dose via the left ... | 1991 | 1714009 |
| presence of a cholinergic projection from ventral striatum to amygdala that is not immunoreactive for ngf receptor. | by combining the retrograde axonal transport of a fluorescent dye with nerve growth factor (ngf) receptor or choline acetyltransferase (chat) immunocytochemistry, we show that the cholinergic neurons that project most strongly to the basolateral nucleus of the amygdala in the ferret do not possess ngf receptor immunoreactivity in their soma and are situated in the ventral striatum, an area known to receive a massive reciprocal projection from the basolateral nucleus of the amygdala. | 1991 | 1715538 |
| is nerve growth factor required for the survival of retinal ganglion cells during development? | staining for nerve growth factor receptor was observed in the ferret's retinal ganglion cell layer, optic nerve and tract, and in the lateral geniculate nucleus and superficial layers of the superior colliculus in the prenatal period, but had disappeared by birth. thus the incidence of this transient staining does not correspond with the ganglion cell death that is known to occur in the ferret retina during the first postnatal week. | 1991 | 1715802 |
| a golgi study of dendritic development in the dorsal lateral geniculate nucleus of normal ferrets. | the development of neurons in the dorsal lateral geniculate nucleus (dlgn) of pigmented ferrets was studied by using the golgi-hortega technique. in adult ferrets, four dlgn cell classes were defined on the basis of somatic and dendritic morphology. classes 1 and 2 were divided into stellate and oriented subtypes. class 1 and 4 cells are characterized by filiform appendages, class 2 cells by club-like appendages, and class 3 cells by stalked appendages. at birth, dlgn neurons have simple dendrit ... | 1991 | 1716647 |
| factors released from endocardium of the ferret and pig modulate myocardial contraction. | 1. in isolated heart muscle preparations, selective removal of the endocardium results in a characteristic and unusual negative inotropic effect. possible mechanisms for this effect were investigated in this study. 2. in endocardium-intact preparations of ferret papillary muscle, 8-bromo-cyclic gmp, sodium nitroprusside, atrial natriuretic peptide (anp) and substance p each induced changes in contractile behaviour similar to selective endocardial removal, and each significantly elevated myocardi ... | 1991 | 1716674 |
| patchy intrinsic connections of the ferret primary auditory cortex. | small iontophoretic injections, of the leucoagglutinin extracted from phaseolus vulgaris (pha-l), were made at a depth of 600 microns, into the ferret primary auditory cortex (ai). the lectin anterogradely labelled the axons of pyramidal cells located in the upper layers. the axons had collaterals which terminated in 5-8 columns within ai. the columns were 0.25-0.8 mm in diameter and, based on their position, appeared to be in areas of cortex where the cells would have higher and lower as well a ... | 1991 | 1717047 |
| effects of new and potent methanesulfonanilide class iii antiarrhythmic agents on myocardial refractoriness and contractility in isolated cardiac muscle. | the effects of the new and potent methanesulfonanilide class iii antiarrhythmic agents (e-4031, uk-66,914, and uk-68,798) on myocardial refractoriness and contractility were compared to those of d-sotalol in ferret isometrically contracting right ventricular papillary muscle preparations. during 1 hz pacing at 37 degrees c, the four class iii agents elicited concentration-dependent increases in ventricular effective refractory period (erp), with a relative order of potency of uk-68,798 greater t ... | 1991 | 1720841 |
| alterations of intracellular calcium homeostasis and myocardial energetics in acute adriamycin-induced heart failure. | to elucidate the mechanism of acute contractile failure induced by adriamycin, the intracellular concentrations of free calcium ([ca2+]i) and energy-related phosphate compounds were determined in isolated ferret hearts. the time-averaged [ca2+]i was measured at 10 min resolution using fluorine nuclear magnetic resonance (nmr) spectroscopy and the nmr-sensitive ca2+ indicator 5f-bapta. [ca2+]i significantly increased from a control of 381 +/- 66 nm (mean +/- sem, n = 5) to 789 +/- 171 nm during 3 ... | 1991 | 1720844 |
| triggered activity as a possible mechanism for arrhythmias in ventricular hypertrophy. | to study the cellular mechanisms of arrhythmias occurring in cardiac hypertrophy, we performed standard microelectrode studies on papillary muscles isolated from control (group n) and hypertrophied ferrets right ventricles. different stages of hypertrophy, induced by pulmonary banding, were studied: 10-22 days (group h1), 4-6 weeks (h2), and 5 1/2-6 months (h3). during the development of hypertrophy, under beta-adrenergic stimulation, triggered activity (ta) induced by delayed afterdepolarizatio ... | 1991 | 1721166 |
| neural regulation of lysozyme secretion from tracheal submucosal glands of ferrets in vivo. | to investigate how central and peripheral nerves affect lysozyme secretion from tracheal submucosal glands in ferrets we injected substance p (20 nmol/kg in 200 microliters) intracisternally or intravenously into anesthetized artificially ventilated ferrets. we collected 3-ml samples from a perfused (3 ml/5 min) segment of trachea in situ during 15 min before and 45 min after injection of substance p. content of lysozyme, a specific marker of tracheal submucosal gland serous cell secretion in fe ... | 1991 | 1721905 |