Publications

organization of the epaxial muscles in terrestrial and arboreal primates.	the erector spinae muscles of the patas monkey hamadryas baboon, and spider monkey were dissected and the origins and insertions were described in detail. in the two terrestrial monkeys, a well-developed thoracolumbar segment of the muscle was observed. this trait seems to correlate to the sagittal movement of this region required in the pronograde quadrupedal locomotion. on the other hand, the erector spinae muscle of the spider monkey is quantitatively not so well developed and the arrangement ...	1996	8953747
fetal ultrasonography: normal biometric ranges in the baboon (papio hamadryas).	normal biometric ranges for fetal growth in a captive breeding baboon (papio hamadryas) colony are described. measurements include crownrump length, biparietal diameter, binocular distance, head circumference, abdominal circumference, femur length and amniotic fluid index. the pattern of fetal growth is compared with other baboon subspecies and man. the uses and limitations of such data for breeding colony management and optimum utilisation of experimentally derived data are discussed.	1996	9029398
changes of extracellular matrix in a baboon (papio hamadryas) model of insulin dependent diabetes: studies using electron microscopy and x-ray diffraction techniques.	extracellular matrix plays an important role in many physiological functions and its abnormalities are thought to play a key role in the pathogenesis of diabetic complications. in this paper we used the techniques of electron microscopy, immunostaining and x-ray diffraction to document some of the early events in the changes of extracellular matrix in a model of insulin dependent diabetes in baboons. our results show that thickening of basement membrane and enlargement of mesangium are demonstra ...	1996	9031807
precision grips, hand morphology, and tools.	this study asks whether there are discernable links between precision gripping, tool behaviors, and hand morphology in modern hominoids, which may guide functional interpretation of early hominid hand morphology. findings from a three-pronged investigation answer this question in the affirmative, as follows: (1) experimental manufacture of early prehistoric tools provides evidence of connections between distinctive human precision grips and effective tool making. (a connection is not found betwe ...	1997	9034041
conservation of human chromosome 18 in baboons (papio hamadryas): a linkage map of eight human microsatellites.	a panel of 25 microsatellite loci known to map to human chromosome 18 was screened for length polymorphisms in a multigenerational pedigree of baboons (papio hamadryas). eight of these loci were polymorphic in the baboon pedigrees, with observed heterozygosity values ranging from 0.16 to 0.88. all eight loci show strong evidence of linkage. the most likely map order among the microsatellite loci for papio is completely compatible with the locus order found in the human genome, and sex difference ...	1996	9067425
the response of group-housed baboons to three enrichment toys.	the behaviour of group-housed baboons was compared before and after the provision of durable cage toys. one adult male hamadryas baboon and 13 adult female olive baboons living in a large enclosure were observed after they were given seven nylon bones, seven kong toys and seven plaque attackers. observations were conducted four times per week on each subject over a 6-week period. abnormal, cage-directed, inactive and self-directed behaviours all significantly decreased after the provision of the ...	1997	9121112
simian t-lymphotropic virus type 1 (stlv-1) infection in wild yellow baboons (papio hamadryas cynocephalus) from mikumi national park, tanzania.	serum and peripheral blood leukocytes from wild yellow baboons (papio hamadryas cynocephalus) were tested for the presence of stlv-1-specific antibodies and proviral dna. fourteen of 30 sera tested positive by radioimmunoprecipitation assay (ripa) with htlv-1. among 36 dna samples tested by pcr 15 were positive by double nested pcr for a fragment of the stlv-1 env gene, the most sensitive assay among pcr tests employed. of 30 animals that were tested both serologically and by pcr in only 1 case ...	1997	9123842
[morpho-immunologic phenotypes of t-cell non-hodgkin's malignant lymphoma in baboons and their connection with with t-lymphotropic retrovirus stlv-1].	8 cytological types were detected among 58 cases of t-nhl of papio hamadryas according to human updated kiel classification (1988). 5 of them were of low grade (lymphocytic, prolymphocytic, t-zone, angioimmunoblastic, small cell pleomorphic) and 3-of high grade (medium and large cell pleomorphic, immunoblastic, large cell anaplastic cd30/ki-1+). there are differences in a tumor structure and generalization in baboon and human lymphomas in spite of significant similarities. stlv-1 presence (antib ...	1997	9139601
[preparation and characteristics of cultured strains of hepatitis a virus from humans and monkeys].	cultural strains of hepatitis a virus (hav) have been isolated from spontaneously infected macaca mulatta (hav-mm), papio hamadryas (hav-ph), african green monkeys cercopithecus aethiops (hav-ca), and patients (hav-h). the strains replicate in continuous cells lines agmk, 4647, vero, and frhk-4. agmk and 4647 cells are the most permissive at 32 degrees c. virus propagation was not associated with the cytopathic effect and could be detected by enzyme immunoassay (eia), immune electron microscopy ...	1997	9182400
complete nucleotide sequence of the new simian t-lymphotropic virus, stlv-ph969 from a hamadryas baboon, and unusual features of its long terminal repeat.	a third type of primate t-lymphotropic virus, ptlv-l, with stlv-ph969 as a prototype, has recently been isolated from an african baboon (papio hamadryas). classification of this virus has been based on partial sequence analysis of cdna from a virus-producing cell line, ph969. we obtained the complete nucleotide sequence of this virus with a proviral genome of 8,916 bp. all major genes, homologous in all human t-cell lymphotropic virus (htlv)-related viruses, and their corresponding mrnas, includ ...	1997	9188619
[quantitative patterns in the clinical manifestations of radiation sickness in large laboratory animals exposed to radiation at superlethal doses. the quantitative patterns in the manifestations of radiation sickness in monkeys].	radiation sickness manifestations have been studied in two species (macaca fascicularis and papio hamadryas) exposed to electron and gamma-neutron radiations in a wide supralethal doses range. dose-response relationships have been calculated for mortality and some clinical manifestations of the intestinal and cerebral forms of radiation sickness. higher radiosensitivity of baboons in comparison with macaca fascicularis and clinically more dangerous damage due to electrons as compared to gamma-ne ...	1997	9244532
[follow-up study of the evolution of the quantitative eeg in intraventricular infusion of nerve growth factor in an aged baboon].	the animal model of aged monkeys is a good homologue of alzheimer's disease in humans, in which it has been shown that there is disproportionate slowing of the eeg when compared with healthy subjects paired for age. this is found both on the conventional eeg and quantitatively. in the latter, relative energy has been the measurement most commonly used for diagnosis and follow-up with various treatments. the follow-up parameters evaluated in this study were: absolute and relative energy of the qu ...	1997	9244612
genetics of adult body mass and maintenance of adult body mass in captive baboons (papio hamadryas subspecies).	adult body mass and changes in mass during an individual's life are important indicators of general health and reproductive fitness. therefore, characterization of the factors that influence normal variation in body mass has important implications for colony management and husbandry. the main objective of this study was to quantify the genetic contribution to adult body mass and its maintenance in baboons. intra-individual mean and variance in body mass were calculated from multiple weight measu ...	1997	9261509
[study of the effectiveness of recombinant alpha2-interferon and its inducers in primates with orthopoxvirus infection].	the interferon-inducing and antiviral activities of high-molecular interferon inducers larifan and rifastin and of gene engineering human alpha 2-interferon were studied in monkeys infected with smallpox. these agents appreciably prolonged the life span of infected monkeys. for green monkeys the drug efficacies were as follows: larifan protected 50%, rifastin 86%, and realderon 50% (if used for treatment) and 80% (if used for urgent prophylaxis) of animals from death; for papio hamadryas the eff ...	1997	9304302
ontogenetic changes in genetic regulation of fetal morphometrics in baboons (papio hamadryas subspp.).	it is known that different genes are expressed during ontogeny; however, it is unclear how variation in that expression is associated with changes in growth patterns. the objective of this study is to assess how genetic variation in fetal morphology changes with ontogeny in baboons. longitudinal measures of the head and femur (60 to 180 days gestation) were available for 892 pregnancies. we used a genetic model that allowed both the genetic and environmental variances (sigma 2g and sigma 2e) to ...	1997	9353978
androgen effects on bioactive and immunoreactive gonadotrophin levels during puberty in male baboons.	the effect of androgens on changes in circulating lh and fsh during pubertal development was examined longitudinally in a 3 year study in male hamadryas baboons. baboon lh and fsh were measured by a species-specific radioimmunoassay and bioactive lh (b-lh) was measured by the mouse in vitro leydig cell bioassay. control baboons (n = 5) progressed normally through puberty. eight baboons were castrated prepubertally; of these four received testosterone implants at the chronological age (ca) of cli ...	1997	9364367
growth and hormone characteristics of pubertal development in the hamadryas baboon.	the semi-longitudinal collection of growth measurements in male and female hamadryas baboons has enabled documentation of the timing of puberty and the development of sexually dimorphic growth patterns in body weight, crown-rump length (crl), limb lengths, and muscle mass. in addition, another sexually dimorphic characteristic appears to be the presence of a pubertal growth spurt in body weight, and possibly crl, in male but not female baboons. serum testosterone levels rose during male developm ...	1997	9379482
phylogenetic analysis of a simian t lymphotropic virus type i from a hamadryas baboon.		1997	9390755
effects of ketamine sedation on glucose clearance, insulin secretion and counterregulatory hormone production in baboons (papio hamadryas).	since the effects of ketamine sedation seem to differ between subspecies of baboons, we assessed the endocrine response to an intravenous glucose tolerance test (ivgtt) in 12 hamadryas baboons. the first phase insulin secretion, basal insulin, and glucose levels, as well as the glucose clearance, were significantly lower in sedated baboons as compared to fully awake animals. glucagon and cortisol were significantly higher, while growth hormone was lower during ketamine sedation. papio hamadryas ...	1997	9438225
male fights of hamadryas baboons	an attempt is made to develop a model of male fights which can account for the stylized facts, observed by kummer and his team, for hamadryas baboons. by two special versions of the general model it is shown that these observations can be consistently explained by one mathematical model which may deserve some interest for its own sake. to demonstrate the relative advantages of our approach we also analyse an ad hoc-type of model.copyright 1998 academic press limited copyright 1998 academic press ...	1998	9473387
establishment of a method for analysis of chimerism in a baboon model (papio hamadryas) of islet/bone marrow transplantation.		1998	9532174
isolation of mycobacterium bovis from baboons, leopards and a sea-lion.	this study reports on two series of cases of mycobacterium bovis infection in zoo animals. the first was in a captive population of baboons (papio hamadryas) and the second in a mixed group of wild mammals, including four leopards (panthera uncia and panthera pardus) and a sea-lion (otaria byrona). the isolation and identification of strains of m. bovis confirmed the presence of m. bovis infections in both zoos. the epidemiological study using genetic markers such as the is6110-based dna fingerp ...	1998	9601152
[characteristics of experimental models of hepatitis a in papio hamadryas].	hepatitis a (ha) was induced in 14 papio hamadryas by strain vha-ph isolated from this species of monkeys with spontaneous infection, strain vha-mm isolated from macaca mulatta, and a unique strain vha-h3 isolated from a patient; this latter strain is pathogenic for macaca mulatta in experiment. all infected seronegative animals developed a disease with virological, serological, biochemical, and morphological signs characteristic of human ha, but the duration of these signs manifestation varied. ...	1998	9606873
astroglial interlaminar processes in the cerebral cortex of prosimians and old world monkeys.	previous observations have shown that astrocytes with interlaminar processes are present in the cerebral cortex of humans and new and old world monkeys, but not in the rodent. the present report furthers the analysis of possible evolutionary aspects regarding the expression of such astroglial features. a comparison between young and adult microcebus murinus, a prosimian, and old world monkeys (macaca mulatta and papio hamadryas) is presented. brain samples were processed for glial fibrillary aci ...	1998	9623670
evolution of the primate androgen receptor: a structural basis for disease.	androgen effects mediated by the androgen receptor (ar) are essential for male reproductive development and virilization. comparison of ar dna coding sequence from five primate species, homo sapiens (human), pan troglodytes (chimpanzee), papio hamadryas (baboon), macaca fascicularis (macaque), and eulemur fulvus collaris (collared brown lemur), supports their phylogeny with complete conservation of the dna and steroid binding domain protein sequence. a linear increase in trinucleotide repeat exp ...	1998	9732460
a baboon (papio hamadryas) with an isochromosome for the long arm of the x.	a 5.5-yr-old female baboon was evaluated for sexual immaturity. she was small for her age and had normal external female genitalia. however, she lacked cyclical perineal turgescence and displayed atypical coloration of the perineal skin. laparoscopy revealed a small uterus and absence of both ovaries. cytogenetic analysis revealed a 42,x,i(x)(q10) karyotype. dna analysis using loci dxs1683, which maps to xp22.1, and dxs297, which maps to xq27.3, was consistent with inheritance of the normal x ch ...	1998	9763665
baboon/human homologies examined by spectral karyotyping (sky): a visual comparison.	baboon (papio hamadryas) metaphase chromosomes were analyzed using spectral karyotyping (sky), a technique combining fluorescence microscopy, ccd-imaging, and fourier spectroscopy. results from a comparison of sky analyses using probes derived from human chromosomes on baboon metaphases were consistent with the majority of comparative gene mapping data between the two species. these data were also compatible with earlier studies comparing macaque and human chromosomes. human (hsa) chromosome 2 w ...	1998	9763666
[cytogenetic characteristics t-lymphoid cell lines of hamadryas baboon (papio hamadryas)].		1998	9825147
imaging dopamine d4 receptors in the living primate brain: a positron emission tomography study using the novel d1/d4 antagonist [11c]sdz glc 756.	the dopamine d4 receptor has lately attracted interest since it has been hypothesized to be involved in the pathogenesis and pharmacotherapy of neuropsychiatric diseases. the present study provides first in vivo evidence of dopamine d4 receptors in primate brain using a [11c]benzo[g]quinoline, the novel radioligand [11c]sdz glc 756 ([11c]glc: in vitro dissociation constants at human receptor clones [nm]: 1.10 at d1; 0.40 at d2; 25 at d3; 0.18 at d4.2; 6.03 at d5). dynamic positron emission tomog ...	1998	9826226
teratoma with trisomy 16 in a baboon (papio hamadryas).	a teratoma was found during a planned cesarean section in a 10-year-old primigravida baboon. this teratoma had a female sex chromosome complement and trisomy for chromosome 16. this is the first report of a teratoma in a baboon and the first report of a chromosomal abnormality in a nonhuman primate teratoma. it is also the first case in a nonhuman primate to address the mechanism of origin. through the use of genetic markers from human chromosomes 5, 8 and 17, the origin of the teratoma was show ...	1998	9839905
identification of evolutionarily invariant sequences in the protein c gene promoter.	recent studies on human protein c gene expression have revealed the presence of three transcription factor binding sites in close proximity to the transcription start site. binding sites for the liver-enriched hepatocyte nuclear factors 1 and 3 (hnf-1 and hnf-3, respectively) are located immediately upstream of the transcription start site, whereas just downstream of the start site a presently unidentified transcription factor may bind. to identify other candidate transcription factor binding si ...	1998	9847407
molecular timing of primate divergences as estimated by two nonprimate calibration points.	the complete mitochondrial dna (mtdna) molecule of the hamadryas baboon, papio hamadryas, was sequenced and included in a molecular analysis of 24 complete mammalian mtdnas. the particular aim of the study was to time the divergence between cercopithecoidea and hominoidea. that divergence, set at 30 million years before present (mybp) was a fundamental reference for the original proposal of recent hominoid divergences, according to which the split among gorilla, chimpanzee, and homo took place 5 ...	1998	9847414
verreaux's eagles (aquila verreauxi) as potential predators of hamadryas baboons (papio hamadryas hamadryas) in eritrea.	in this paper we describe for the first time encounters of verreaux's eagle (aquila verreauxi) with hamadryas baboons (papio hamadryas hamadryas) in the central highlands of eritrea (15 degrees 22' n, 38 degrees 58' e, 2300 m). during 12 h of observation on 4 days, we observed four encounters of verreaux's eagles with baboons, of which three can be classified as possible attacks. the baboons always responded with alarm calls. in three cases some immatures rushed to adult group members and clung ...	1999	9888722
pleiotropy and genotype by diet interaction in a baboon model for atherosclerosis: a multivariate quantitative genetic analysis of hdl subfractions in two dietary environments.	we investigated dietary effects on pleiotropic relationships among 3 hdl cholesterol (c) subfractions (hdl1-c, hdl2-c, and hdl3-c; levels quantified by gradient gel electrophoresis) for 942 pedigreed baboons (papio hamadryas) who were fed a basal (chow) diet and a high cholesterol, saturated fat (hcsf) challenge diet. using multivariate maximum likelihood methods we estimated heritabilities for all 6 traits, genetic and environmental correlations (rhog and rhoe) between them, and the additive ge ...	1999	10195946
female dominance and female social relationships among yellow baboons (papio hamadryas cynocephalus).	adult females in a female-bonded, cercopithecine species such as baboons are characterized by hierarchically ranked matrilines, i.e., female offspring assume rankings just beneath those of their mothers. in this system of closely ranked matrilines, a female should engage in significantly more affiliative interactions with those individuals who are closely ranked to herself than with those individuals who are more distantly ranked. we examine the hypothesis that females in this troop of feral yel ...	1999	10206209
cerebrospinal fluid monoaminergic metabolites differ in wild anubis and hybrid (anubis hamadryas) baboons: possible relationships to life history and behavior.	the article reports monoaminergic metabolite [homovanillic acid (hva), 5-hydroxyindoleacetic acid (5-hiaa), and 3-methoxy-4-hydroxyphenylglycol (mhpg)], values from the cerebrospinal fluid (csf) of 27 wild baboons (papio hamadryas) aged 40 to 140 months. animals were either anubis, or anubis with hamadryas admixture; males of the latter subspecies generally have a reduced tendency to disperse from their natal groups. overall, the values and interrelationships among the csf monoamine metabolites ...	1999	10327421
an alu insertion polymorphism in a baboon hybrid zone.	a novel polymerase chain reaction (pcr) primer pair was used to analyze the frequency of insertion of the first described, nonhuman, baboon-specific alu repetitive element in populations from the papio hamadryas anubis and the papio hamadryas hamadryas subspecies, and from a number of anubis-hamadryas hybrids. the alu insertion is found in intron 7 of the baboon lipoprotein lipase (lpl) gene. each of the populations had different frequencies for the insertion, and the hybrids examined had a freq ...	1999	10342460
[evoked potentials in the sacred baboon: long-term follow-up of intracerebroventricular infusion of nerve growth factor].	it is well known that in aged animals cognitive deficit occurs, homologous with that occurring in alzheimer's disease in humans, and as has been shown in others species, this may be attenuated by administration of nerve growth factor (ngf). therefore the basic aim of this study was to make an electrophysiological evaluation of the repercussion that there might be after long-term administration of this neurotropin in the sacred baboon (papio hamadryas) comparing aged with young animals.	2009	10363290
biochemistry and haematology values for the baboon (papio hamadryas): the effects of sex, growth, development and age.	a retrospective study evaluated the influence of sex and age on plasma biochemistry and haematology parameters in a captive-bred colony of baboons. over 1,140 etda and heparin blood samples were obtained from 160 clinically normal baboons between the ages of 11 months and 11 years. data for these blood tests were analysed for the effects of sex, age and sex age interactions. sex, age and sex age interactions were detected for many plasma biochemistry and haematological parameters. the reference ...	1999	10372537
[growing divergence inside primate t cell lymphotropic viruses].	during our studies on the evolution of the ptlvs, we have isolated and genomically characterized two divergent simian t-lymphotropic viruses, not belonging to the previously well-established ptlv lineages. stlv-ph969 has been isolated from an eritrean sacred baboon (papio hamadryas), with an htlv-like indeterminate serological profile. the entire 8916 nt long genomic sequence, was obtained from a cdna library of ph969 mrna, in combination with a pcr based strategy. all open reading frames (orf) ...	1999	10379197
long-term survival and function of intrahepatic islet allografts in baboons treated with humanized anti-cd154.	clinical islet cell transplantation has resulted in insulin independence in a limited number of cases. rejection, recurrence of autoimmunity, and impairment of normal islet function by conventional immunosuppressive drugs, e.g., steroids, tacrolimus, and cyclosporin a, may all contribute to islet allograft loss. furthermore, intraportal infusion of allogeneic islets results in the activation of intrahepatic macrophages and endothelial cells, followed by production of proinflammatory mediators th ...	1999	10389857
histopathological and parasitological changes in baboons (papio hamadryas) experimentally infected with baboon and human isolates of schistosoma mansoni from saudi arabia: a comparative study.		1999	10474648
the discovery of two new divergent stlvs has implications for the evolution and epidemiology of htlvs.	we have isolated and characterised two divergent simian t-lymphotropic viruses (stlv), not belonging to the established human and simian t-lymphotropic virus lineages htlv-1/stlv-1 and htlv-2. stlv-l, from an eritrean sacred baboon (papio hamadryas), has been typed as a third type of simian t-lymphotropic virus, distinct from htlv-1/stlv-1 and htlv-2. the other virus, isolated from congolese bonobos (pan paniscus), is a distinct member of the htlv-2 clade and has been designated stlv-2. the isol ...	1999	10479777
new world, but not old world, monkeys carry several genes encoding beta-microseminoprotein.	it was shown by southern hybridization that cotton-top tamarin and common marmoset, new world monkeys, carry three or more genes encoding beta-microseminoprotein, also known as psp94. in contrast, the genomes of old world monkeys, as represented by rhesus macaque and sacred baboon, contain a single gene. clones containing three different genes encoding beta-microseminoprotein were isolated from a cotton-top tamarin genomic library. they carry two complete genes of four exons and a third gene lac ...	1999	10491085
cytogenetic and fertility studies of a rheboon, rhesus macaque (macaca mulatta) x baboon (papio hamadryas) cross: further support for a single karyotype nomenclature.	historically, two different numbering systems have been used to describe the baboon and macaque karyotypes. however, g-banding studies and, more recently, fluorescence in situ hybridization results have shown that the two karyotypes are virtually identical. to confirm this hypothesis, cytogenetic analysis of an unusual animal, a rheboon, was undertaken. the rheboon reported here, an 18-year-old male, is the only long-term survivor of 26 pregnancies resulting from matings between female baboons ( ...	1999	10502238
low-dose nitro-l-arginine administration in baboon (papio hamadryas) pregnancy.	1. the purpose of the present study was to examine the effect of nitric oxide (no) inhibition on mean arterial pressure (map), endothelin (et) and the renin-aldosterone system in pregnancy in the non-human primate (baboon). 2. twenty pregnant baboons (papio hamadryas) were examined prospectively after the administration of an oral no inhibitor in different phases of pregnancy. haemodynamic responses to no inhibition, evidence of pre-eclampsia and the renin-aldosterone system were examined under ...	1999	10561803
molecular phylogeny of old world monkeys (cercopithecidae) as inferred from gamma-globin dna sequences.	dna sequence data of the nuclear-encoded gamma1-gamma2-globin duplication region were used to examine the phylogenetic relationships of 16 cercopithecid (old world monkey) species representing 12 extant genera. morphology- and molecular-based hypotheses of old world monkey branching patterns are generally congruent, except for generic relationships within the subtribe papionina. the cercopithecids divide into colobines (leaf-eating monkeys) and cercopithecines (cheek-pouched monkeys). the colobi ...	1999	10603263
"rodent-like" and "primate-like" types of astroglial architecture in the adult cerebral cortex of mammals: a comparative study.	previous observations disclosed that astroglia with interlaminar processes were present in the cerebral cortex of adult new and old world monkeys, but not in the rat, and scarcely in the prosimian microcebus murinus. the present report is a more systematic and comprehensive comparative analysis of the occurrence of such processes in the cerebral cortex of several mammalian species. brain samples were obtained from adult individuals from the following orders: carnivora (canine), rodentia (rat and ...	2000	10672363
functional and structural abnormalities in the nerves of type i diabetic baboons: aminoguanidine treatment does not improve nerve function.	to improve understanding of the pathophysiology of diabetic neuropathy and to establish a primate model for experimental studies, we examined nerve changes in baboons with type i (insulin-dependent) diabetes mellitus. we also examined the effect of aminoguanidine (an inhibitor of the formation of advanced glycation end products) on nerve function.	2000	10672451
immune and pathophysiological processes in baboons experimentally infected with ebola virus adapted to guinea pigs.	the dynamics of pathophysiological and immunological parameters monitored in monkeys papio hamadryas infected with the guinea pig-adapted ebola virus strain demonstrated that this viral strain preserved its virulence for monkeys and caused the disease with characteristic features similar to those caused by non-adapted ebola virus. however, certain previously unknown patterns have been observed: (1) prolongation of the febrile period by two days; (2) extended period was characterized by stability ...	2000	10714441
filamentous tau pathology in nerve cells, astrocytes, and oligodendrocytes of aged baboons.	intracellular filamentous inclusions containing abnormally phosphorylated tau protein are hallmarks of several human neurodegenerative disorders. this study reveals tau-positive cytoskeletal abnormalities in neurons and glial cells of aged baboons. the brains of four baboons (papio hamadryas, 20-30 yr of age) were examined using the gallyas silver technique for neurofibrillary changes and phosphorylation-dependent anti-tau antibodies (at8, at100, at270, phf-1, tg-3). conspicuous changes were not ...	2000	10744034
absence of evidence of infection with divergent primate t-lymphotropic viruses in united states blood donors who have seroindeterminate htlv test results.	recent identification of divergent simian or primate t-lymphotropic viruses (stlvs; ptlvs) in bonobos (formerly called pygmy chimpanzees; pan paniscus; viruses: stlvpan-p and stlvpp1664) and a baboon (papio hamadryas; viruses: stlvph969 or ptlv-l) have raised the possibility of human infection with these viruses. divergent ptlv-infected primate sera show p24 bands on htlv-i western blots (wbs). it was investigated whether infection by divergent ptlv-like viruses could explain a subset of united ...	2000	10773057
two takeovers in wild hamadryas baboons.		2006	10828697
changes of hormonal function of the adrenal and gonadal glands in baboons of different age groups.	the purpose of this study was to characterize the changes of hormonal function of the adrenals and gonads during aging in male baboons (papio hamadryas). basal levels of plasma dehydroepiandrosterone, dehydroepiandrosterone sulfate, pregnenolone, and 17-hydroxypregnenolone progressively decrease with age from 10-15 years when analyzed by specific radioimmunoassay. however, no significant changes were found in cortisol and 11-desoxycortisol concentrations. the levels of sexual hormones did not di ...	2000	10870672
infection of nonhuman primate cells by pig endogenous retrovirus.	the ongoing shortage of human donor organs for transplantation has catalyzed new interest in the application of pig organs (xenotransplantation). one of the biggest concerns about the transplantation of porcine grafts into humans is the transmission of pig endogenous retroviruses (perv) to the recipients or even to other members of the community. although nonhuman primate models are excellently suited to mimic clinical xenotransplantation settings, their value for risk assessment of perv transmi ...	2000	10906227
conservation in decay accelerating factor (daf) structure among primates.	the decay accelerating factor (daf, cd55) protects self cells from activation of autologous complement on their surfaces. it functions to disable the c3 convertases, the central amplification enzymes of the cascade. its active site(s) are contained within four approximately 60 amino acid long units, termed complement control protein repeats (ccps), which are suspended above the cell surface on a 68 amino acid long serine/threonine (s/t)-rich cushion that derives from three exons. we previously p ...	2000	10906393
a genetic linkage map of the baboon (papio hamadryas) genome based on human microsatellite polymorphisms.	a first-generation genetic linkage map of the baboon (papio hamadryas) genome was developed for use in biomedical and evolutionary genetics. pedigreed baboons (n = 694) were selected from the breeding colony maintained by the southwest foundation for biomedical research. to facilitate comparison with the human genome, the baboon linkage map consists primarily of human microsatellite loci amplified using published human pcr primers. genotypes for 325 human microsatellites and 6 novel baboon micro ...	2000	10936045
the core dry-season diet of yellow baboons (papio hamadryas cynocephalus)in ruaha national park, tanzania.		2000	11093039
sexual swellings in female hamadryas baboons after male take-overs: "deceptive" swellings as a possible female counter-strategy against infanticide.	in many primate species, male intanticide is assumed to pose a serious risk for infants, and therefore female counter-strategies are expected. these counter-strategies may include changes in the females' reproductive behavior and physiology, e.g., mating with multiple males and prolonged receptivity. since the risk of infanticide is particularly high when a new male enters the group or when a male rises in rank, we studied the changes in female reproductive conditions, e.g., post-partum amenorrh ...	2000	11132110
pregnancy-specific glycoprotein (psg) in baboon (papio hamadryas): family size, domain structure, and prediction of a functional region in primate psgs.	pregnancy-specific glycoprotein (psg) constitutes a major component of serum of pregnant women and appears to be essential for a successful pregnancy. its function is, however, still unknown. because of the evolutionary divergence between human and rodent psg, functional studies may require a primate animal model. we have characterized psg transcripts in a baboon placenta cdna library and analyzed baboon genomic dna. the main psg isoform had the domain structure n-a1-b2-c similar to the human ty ...	2001	11133662
catarrhine phylogeny: noncoding dna evidence for a diphyletic origin of the mangabeys and for a human-chimpanzee clade.	maximum-parsimony and maximum-likelihood analyses of two of the serum albumin gene's intron sequences from 24 catarrhines (17 cercopithecid and 7 hominid) and 3 platyrrhines (an outgroup to the catarrhines) yielded results on catarrhine phylogeny that are congruent with those obtained with noncoding sequences of the gamma(1)-gamma(2) globin gene genomic region, using only those flanking and intergenic gamma sequences that in their history were not involved in gene conversion. a data set that com ...	2001	11161738
the effects of the menstrual cycle, pregnancy and early lactation on haematology and plasma biochemistry in the baboon (papio hamadryas).	the changes in the haematology and clinical biochemistry associated with the different stages of the menstrual cycle, gestation and lactation in the baboon (papio hamadryas) were evaluated in a prospective longitudinal study. serial edta and heparin blood samples were collected from 12 baboons. haemoglobin concentration, haematorcrit, red blood cell and white blood cell counts were decreased in the luteal compared to the follicular phase (p<0.001); the reverse effect was observed for platelet co ...	2000	11168833
class i mhc expression in the yellow baboon.	mhc class i molecules play a crucial role in the immune response to pathogens and vaccines and in self/non-self recognition. therefore, characterization of mhc class i gene expression of papio subspecies is a prerequisite for studies of immunology and transplantation in the baboon (papio hamadryas). to elucidate mhc class i expression and variation within papio subspecies and to further investigate the evolution of a and b loci in old world primates, we have characterized the expressed class i r ...	2001	11238644
comparative analysis of natural killer cell activity, lymphoproliferation and lymphocyte surface antigen expression in nonhuman primates housed at the cirmf primate center, gabon.	six different species of nonhuman primates housed at the cirmf primate center, cynomolgus monkeys (macaca fascicularis), rhesus monkeys (macaca mulatta), mandrills (mandrillus sphinx), vervets (cercopithecus aethiops pygerythrus), chimpanzees (pan troglodyte) and baboons (papio hamadryas), were evaluated for their natural killer cell activity and for the ability of their peripheral blood mononuclear cells to proliferate in response to known mitogens (concanavalin a, phytohemagglutinin and staphy ...	2001	11396861
characterization of baboon (papio hamadryas) milk proteins.	the major proteins of baboon milk were identified as beta-lactoglobulin (beta lg), alpha-lactalbumin (alpha la), lysozyme, lactoferrin, casein, and albumin by immobiline isoelectric focusing, sds-page, immunoblotting of gels with rabbit antisera to human alpha la, lysozyme, and albumin and bovine beta lg and casein, and n-terminal sequencing of proteins blotted from gels. the first 30 n-terminal residues of baboon beta lg are identical to those of macaque (macaca fasicularis) beta lg except for ...	2001	11444021
cardiovascular structure and function in baboons with type 1 diabetes -- a transvenous ultrasound study.	diabetes mellitus is an important risk factor for both macrovascular and cardiac disease in humans. the availability of a novel intravenous ultrasound probe allows detailed interrogation of a large proportion of the vasculature, as well as the heart, during the same examination. six male baboons (papio hamadryas) with type 1 diabetes and known microangiopathy, and six control animals were studied. vascular structure in the major large arteries and cardiac function were studied using transvenous ...	2016	11457668
rank and grooming reciprocity among females in a mixed-sex group of captive hamadryas baboons.	in a mixed-sex, captive group of hamadryas baboons (papio hamadryas hamadryas) we investigated whether female grooming relationships are affected by their dominance ranks. seyfarth's [1977] grooming for support model and barrett et al.'s [1999] biological market model both predict that in primate groups where competition for monopolizable resources is high, grooming among females is based, at least partly, on the interchange of grooming for rank-related benefits, and that rank thus influences th ...	2001	11536314
trace elements concentrations from papio hamadryas teeth sequences.		2001	11603830
a proper study for mankind: analogies from the papionin monkeys and their implications for human evolution.	this paper's theme is that analogies drawn from the cercopithecine tribe papionini, especially the african subtribe papionina (baboons, mangabeys, and mandrills), can be a valuable source of insights about the evolution of the human tribe, hominini, to complement homologies found in extant humans and/or african apes. analogies, involving a "likeness of relations" of the form "a is to b, as x is to y," can be usefully derived from nonhomologous (homoplastic) resemblances in morphology, behavior, ...	2001	11786995
high prevalence of simian t-lymphotropic virus type l in wild ethiopian baboons.	simian t-cell leukemia viruses (stlvs) are the simian counterparts of human t-cell leukemia viruses (htlvs). a novel, divergent type of stlv (stlv-l) from captive baboons was reported in 1994, but its natural prevalence remained unclear. we investigated the prevalence of stlv-l in 519 blood samples from wild-living nonhuman primates in ethiopia. seropositive monkeys having cross-reactive antibodies against htlv were found among 22 out of 40 hamadryas baboons, 8 of 96 anubis baboons, 24 of 50 bab ...	2002	11799159
the nucleotide sequences of the parathyroid gene in primates (suborder anthropoidea).	nucleotide sequences of the parathyroid (pth) gene of 12 species of primates belonging to suborder anthropoidea were examined. the pth gene contains one intron that separates two exons that code the sequence of prepro and pth, respectively. the intron of the pth gene in cebus apella, callithrix jacchus, and saguinus oedipus was 102 bp long, whereas a 103-bp intron was observed in the remaining species. phylogenetic analysis using the nucleotide sequences of pth revealed that these 12 species of ...	2002	11825036
effectiveness of human microsatellite loci for assessing paternity in a captive colony of vervets (chlorocebus aethiops sabaeus).	microsatellite polymorphisms are playing an increasingly vital role in primatological research, and are particularly useful for paternity exclusion in both wild and captive populations. although vervet monkeys (chlorocebus aethiops) are commonly studied in both settings, few previous studies have utilized microsatellite markers for assessing genetic variation in this species. in a pilot project to assess paternity in the ucla-va vervet monkey research colony (vmrc), we screened 55 commercially a ...	2002	11948640
effects of aging on hypothalamic-pituitary-adrenal system function in non-human primates.	the study was aimed at characterizing the changes in hypothalamic-pituitary-adrenal (hpa) axis function during aging in monkey models (papio hamadryas and macaca mulatta). it has been established by specific radioimmunoassay and enzyme immunoassay that basal plasma levels of adrenal androgenes (dehydroepiandrosterone-dhea, dehydroepiandrosterone sulfate-dheas) and the early precursors of steroid hormones (pregnenolone and 17-hydroxypregnenolone) progressively decrease with age in baboons and mac ...	2002	12044968
composition of psoas major muscle fibers compared among humans, orangutans, and monkeys.	in primate species the m. psoas major, the only muscle simultaneously controlling the spinal column and lower extremity, is expected to reflect morpho-functional adaptation to diversified locomotor behavior. by using histochemical analysis with sudan black b staining, composition of different types of muscle fibers in the psoas major was compared between 2 japanese macaques, 2 hamadryas baboons, 2 anubis baboons, 2 orangutans, and 17 humans. the comparison has revealed unique features of this mu ...	2002	12050900
the aging baboon: comparative demography in a non-human primate.	why do closely related primate genera vary in longevity, and what does this teach us about human aging? life tables of female baboons (papio hamadryas) in two wild populations of east africa and in a large captive population in san antonio, texas, provide striking similarities and contrasts to human mortality patterns. for captive baboons at the southwest foundation for biomedical research, we estimate the doubling time of adult mortality rate as 4.8 years. wild females in free-living population ...	2002	12082185
[prediction of the severity of damage and disruption of work ability in reaction of the body to alcohol load prior to radiation exposure in the superlethal range].	in experiments on 121 white non-linear rats, 44 papio hamadryas and 29 macaca fascicularis, animals' reactions on the alcohol impact (ai) and following exposure to supralethal doses were compared. the animals were intravenously injected with 5% ethanol in the glucose solution, 2.1 g/kg for rats and 0.46-0.51 g/kg for monkeys. monkeys' response to ai was scored in four-point scale by estimating of abnormalities in motor activity, coordination of motion and changes in conditioned reflex activity. ...	2002	12125263
the effects of aminoguanidine on renal changes in a baboon model of type 1 diabetes.	the efficacy of aminoguanidine (ag) on primary prevention of diabetic nephropathy was investigated in a nonhuman primate model of type 1 diabetes over a period of 4 years.	2002	12126789
housing and care of monkeys and apes in laboratories: adaptations allowing essential species-specific behaviour.	during the last two decades an increasing amount of attention has been paid to the housing and care of monkeys and apes in laboratories, as has been done with the housing and care of other categories of captive animals. the purpose of this review is to develop recommendations for adaptations of housing and care from our knowledge of the daily behavioural activity of monkeys and apes in natural conditions and in enriched laboratory conditions. this review deals mainly with adaptations of daily ho ...	2002	12144737
experimental mycoplasma infection in monkeys.	experimental mycoplasma infection was studied in papio hamadryas, macaca mulatta, and macaca nemestrina infected with mycoplasma (m. pneumoniae and m. hominis) and ureaplasma (u. urealyticum).	2002	12170317
virus safety in xenotransplantation: first exploratory in vivo studies in small laboratory animals and non-human primates.	for xenotransplantation, the transplantation of animal cells, tissues and organs into human recipients, to date, pigs are favored as potential donors. beside ethical, immunological, physiological and technical problems, the microbiological safety of the xenograft has to be guaranteed. it will be possible to eliminate all of the known porcine microorgansims in the nearby future by vaccinating or specified pathogen-free breeding. thus, the main risk will come from the porcine endogenous retrovirus ...	2002	12180842
ranging behavior, group size and behavioral flexibility in ethiopian hamadryas baboons (papio hamadryas hamadryas).	this study reports group size, home range size, daily path lengths, seasonal effects on ranging behavior and qualitative information on diet for a population of hamadryas baboons inhabiting the lowlands of the northern rift valley in central ethiopia. the minimum home range size and daily path length for this population are similar to those reported for other populations of hamadryas baboons in ethiopia and saudi arabia. group sizes, however, are much larger than those in most other hamadryas po ...	2002	12207056
divergent simian t-cell lymphotropic virus type 3 (stlv-3) in wild-caught papio hamadryas papio from senegal: widespread distribution of stlv-3 in africa.	among eight samples obtained from a french primatology research center, six adult guinea baboons (papio hamadryas papio), caught in the wild in senegal, had a peculiar human t-cell leukemia virus type 2 (htlv-2)-like western blot seroreactivity (p24(+), gd21(+), k55(+/-)). partial sequence analyses of the tax genes (433 bp) indicated that these baboons were infected by a novel divergent simian t-cell lymphotropic virus (stlv). analyses of the complete proviral sequence (8,892 bp) for one of thes ...	2003	12477886
life history and the competitive environment: trajectories of growth, maturation, and reproductive output among chacma baboons.	the social environment is a key feature influencing primate life histories. chacma baboons (papio hamadryas ursinus) are a female-bonded species with a strict linear dominance hierarchy. in this species, the allocation of energy to competing demands of growth and reproduction is hypothesized to vary as a function of competitive ability, which in turn increases with social rank. since growth rate is a major component of life history models, measures of age-specific growth were used to analyze var ...	2003	12489139
detection by pcr and isolation assays of the anaerobic intestinal spirochete brachyspira aalborgi from the feces of captive nonhuman primates.	the purpose of this study was to investigate the presence of the anaerobic intestinal spirochetes brachyspira aalborgi and brachyspira pilosicoli in the feces of captive nonhuman primates (n = 35) from 19 species housed at the zoological gardens, perth, western australia. both spirochete species are known to infect human beings. dna was extracted from freshly collected feces with a commercially available qiaamp dna stool minikit and subjected to pcr protocols amplifying portions of the 16s rrna ...	2003	12624050
discordance of endothelial nitric oxide synthase in the arterial wall and its circulating products in baboons: interactions with redox metabolism.	although peripheral arteries and circulating factors have been frequently used to assess systemic or central arterial, such as coronary artery, endothelial nitric oxide synthase (enos) functions, there is no direct evidence to support that they are related.	2003	12662158
the relative lengths and weights of metacarpals and metatarsals in baboons (papio hamadryas).	the lengths and weights of metacarpals and metatarsals were measured in two collections of baboon skeletons-33 animals, all born and raised in the wild, and 60 animals, nearly all born and raised in captivity. for both length and weight, ratios were constructed for all possible pairings of the five bones in each individual hand and foot. the pattern of results was not identical for the two collections, but substantial sex differences existed in both collections for many of the ratios calculated. ...	2003	12694645
pollical oblique ligament in humans and non-human primates.	a morphological study of the oblique ligament in the thumb is presented. the ligament was consistently described in human specimens and compared with dissections of non-human primates from different species. the oblique ligament was found in some, but not all, specimens in each of the following species examined: chimpanzee, orangutan, gibbon, anubis baboon, hamadryas baboon, squirrel monkey, lemur and marmoset. a revised identity of the oblique ligament is proposed as a reinforced distal border ...	2003	12739617
genetics of leptin expression in baboons.	leptin gene expression is higher in females than in males, and is regulated by many factors including energy intake and insulin, but little is known about the inheritance of leptin gene expression. we have investigated leptin (lep) gene express-ion, to determine whether it is heritable, and whether the difference in lep expression between males and females has a genetic component.	2003	12821961
hematology and blood biochemistry in infant baboons (papio hamadryas).	although published normative reference standards for hematologic and clinical chemistry measures are available for adult baboons, their applicability to infants has not been addressed. we analyzed these measures in 110 infant baboons (55 females and 55 males) from a large breeding colony at the southwest regional primate research center in san antonio, texas. the sample consists of olive baboons and olive/yellow baboon hybrids, 1 week to 12 months of age. we produced cross-sectional reference va ...	2003	12823623
numerity of a socially housed hamadryas baboon (papio hamadryas) and a socially housed squirrel monkey (saimiri sciureus).	to extend a study conducted by e. m. brannon and h. s. terrace (1998, 2000), the authors trained 1 hamadryas baboon (papio hamadryas) and 1 squirrel monkey (saimiri sciureus) to respond to stimuli representing the numerosities 1-4 in ascending order. when tested with novel stimuli of the same numerosities, both subjects' performance appeared to be based on the numerical attributes of stimuli. subjects were then tested on their ability to order pairs of numerosities derived from the values 1-9. b ...	2003	12856792
infant mortality after takeovers in wild ethiopian hamadryas baboons.	in this work we report the first observational evidence of infanticide in wild hamadryas baboons. the study group inhabits the lowlands of the northern rift valley in ethiopia and has been under observation for over 1,200 hr, on and off, since october 1996. here we report observations from august and september 2002 of the consequences of two takeovers of known females with black infants. after the first takeover, the respective infant disappeared and was presumed dead within 11 days of the takeo ...	2003	12874842
effect of diet on dental development in four species of catarrhine primates.	in this study, dental development is described in two pairs of closely related catarrhine primate species that differ in their degree of folivory: 1) hylobates lar and symphalangus syndactylus, and 2) papio hamadryas hamadryas and semnopithecus entellus. growth increments in histological thin sections are used to reconstruct the chronology of dental development to determine how dental development is accelerated in the more folivorous species of each pair. although anterior tooth formation appear ...	2003	12966517
the arnold-chiari malformation in a sacred baboon (papio hamadryas).		1955	13295936
[histochemical observations on bone marrow cellular elements. iv. cytotopochemistry of bone marrow cellule in papio hamadryas].		2006	13404142
studies on spontaneous primary encephalitides in the monkey. i. a polio-encephalitis with predilection for the brain stem in the baboon (papio hamadryas).		1959	13642086
studies on spontaneous primary encephalitides in the monkey. ii. encephalitis with a cortico-striate predilection in the baboon (papio hamadryas).		1959	13642087
[on the "hybrid" antigen in monkeys (theropithecus gelada x papio hamadryas)].		1963	14077733
[the karyotype of papio hamadryas].		2015	14277064
gene expression profiling of alcoholic liver disease in the baboon (papio hamadryas) and human liver.	the molecular pathogenesis of alcoholic liver disease (ald) is not well understood. gene expression profiling has the potential to identify new pathways and altered molecules in ald. gene expression profiles of ald in a baboon model and humans were compared using dna arrays. reverse transcriptase-polymerase chain reaction and immunohistochemistry were used for downstream analysis of array results. cdna array analysis revealed differential expression of several novel genes and pathways in additio ...	2003	14633604
bone mineral density reference standards in adult baboons (papio hamadryas) by sex and age.	osteoporosis is a progressive condition involving structural deterioration of bone tissue, leading to skeletal fragility and an increased susceptibility to fractures due to low bone mass and high rates of bone turnover. areal bone mineral density (abmd) serves as the most reliable predictor of susceptibility to osteoporotic fracture. the development of animal models, including old world monkeys, has been essential to studies of bone mineral density. these animals, including the baboon, exhibit m ...	2003	14678847