Publications
| Title | Abstract | Year Filter | PMID(sorted ascending) Filter |
|---|
| high speed liquid chromatography, 14c-radioassay and spectrophotometry for measuring antipyrine plasma half-life in rhesus monkeys (macaca mulatta). | 6 male rhesus monkeys (macaca mulatta) were treated with 14ch3-n-antipyrine (15 mg/kg, i.v.). antipyrine plasma half-lives (aph) were determined using hslc, radiometric, and spectrophotometric methods. aphs obtained by hslc analysis of plasma extracts were lower than radiometric and spectrophotometric determinations. the three procedures were investigated to determine if coextraction of metabolites might be responsible for differences in aph. all three solvent systems extract significant quantit ... | 1978 | 98774 |
| experimental spinal cord trauma, ii: blood flow, tissue oxygen, evoked potentials in both paretic and plegic monkeys. | graded clinical motor deficits were produced in a series of rhesus monkeys subjected to experimental spinal cord trauma from a variety of impact loads. an argon washout technique was used to measure spinal cord blood flow; tissue oxygen carbon dioxide, and somatosensory evoked potentials (seps) were also monitored. each animal received a clinical grade and, after a week of study, the spinal cords were removed for histopathological grading. blood flow in paraplegic animals was significantly decre ... | 1978 | 98856 |
| experimental spinal cord trauma, iii: therapeutic effect of immobilization and pharmacologic agents. | a wide variety of pharmacologic agents has been suggested to serve as therapeutic adjuncts in the management of acute spinal cord trauma. the present study was conducted to determine what effect, if any, these agents have when they are added to immobilization of the spinal column, the most widely used clinical measure. rhesus monkeys were subjected to different levels of experimental spinal cord injury with and without subsequent immobilization by means of a figure of eight ligature. in the cont ... | 1978 | 98857 |
| an ontogenic study of the acute inflammatory response in the fetal rhesus monkey. ii. the mediation of increased vascular permeability by histamine, compound 48/80 and bradykinin. | vascular permeability as a function of age was evaluated quantitatively and morphologically in skin of fetal rhesus monkeys given vasoactive mediators. the response was examined at 90, 120 or 150 days of gestation or at birth and compared to the response of yearling rhesus monkeys. skin sites were challenged with histamine, compound 48/80 or bradykinin. evans' blue and horseradish peroxidase were used as markers of vascular integrity. evans' blue was quantitated spectrophotometrically. vascular ... | 1978 | 98895 |
| [the question of the validity of haptoglobin/g-streptococci relations in nonhuman sera]. | the relationship between haptoglobin type and the agglutinability of some group g streptococci, which was observed in humans, could also be demonstrated in animal sera. in humans the haptoglobin type hp 1-1 is correlated with a lacking or very low agglutinability. sera of 10 rhesus monkeys showed hp-type 1-1 and agglutinated the streptococci only to dilutions of the serum up to 1:4. the sera of 48 pigs contained an hp 1-1 like type and a streptococcus agglutination titer of max. 1:10. seven ahap ... | 1977 | 98943 |
| determination of disaturated lecithin in rhesus monkey amniotic fluid as an index of fetal lung maturity. | although increased concentrations of total lecithin in amniotic fluid allow prenatal assessment of fetal lung maturation, it has become clear that routine use of the l/s index may lead to a substantial number of inaccurate predictions. since disaturated lecithin (dl) is a more specific marker of pulmonary surfactant than total lecithin, we developed a convenient method for measuring this phospholipid in amniotic fluid, and then evaluated its level in pregnant rhesus monkeys of 120 to 163 days of ... | 1978 | 99039 |
| protraction of maxilla in rhesus monkeys by controlled extraoral forces. | 1978 | 99041 | |
| the effect of complement depletion on bacterial lipopolysaccharide (lps)-induced hemodynamic and hematologic changes in the rhesus monkey. | lipopolysaccharide (lps) isolated from salmonella minnesota r595 or from escherichia coli 0111:b4 induces hypotension in rhesus monkeys with normal complement levels. this hypotension is accompanied by decreased total peripheral resistance. the depletion of c3 and terminal complement components by prior intraperitoneal administration of the anticomplementary protein cobra factor did not alter the hemodynamic changes which occur following the rapid injection of 5 mg/kg of r595 lps, the infusion o ... | 1978 | 99042 |
| congenital hydrocephalus. animal model: congenital hydrocephalus produced by attenuated influenza a virus vaccine in rhesus monkeys. | 1978 | 99044 | |
| hyaline membrane disease. effect of surfactant prophylaxis on lung morphology in premature primates. | neonatal lung morphology was evaluated in 12 rhesus monkeys delivered by caesarean section 1 month before term and cared for as human premature neonates. in 6 monkeys, 0.20 to 0.27 ml of natural rabbit surfactant (sa) was instilled intratracheally before the first breath; the other 6 served as controls. histology and morphometry of the controls' lungs revealed changes typical of hyaline membrane disease (hmd) in human premature infants, whereas the sa-treated lungs showed improved alveolar expan ... | 1978 | 99046 |
| antiserums for immunofluorescent enumeration of human t lymphocytes utilizing fluoresceinated staphylococcal protein a. | five lots (100 ml or more) of heterologous antiserums specific for human t lymphocytes were prepared using human or rhesus monkey thymocytes as immunogens. after appropriate adsorptions, these antiserums reacted by immunofluorescence with 68% of human peripheral blood mononuclear cells and 98% of human thymocytes, with e-rosette--positive cells but not with eac-rosette--positive cells or five human b-lymphoblastoid-cell lines. blocking experiments showed that rhesus monkey thymocytes share thymi ... | 1978 | 99047 |
| tissue reacting antibodies in a rhesus monkey with long-term trypanosoma cruzi infection. | immunoglobulins (igs) reacting against endothelial and vascular structures and striated muscle cells as well as against cells from a peripheral nerve were detected by indirect immunofluorescent test (iif) in a rhesus monkey infected for 29 yr with trypanosoma cruzi. anti-t. cruzi antibodies in this monkey showed a titer of 1:128 in the iif test and the direct agglutination test. tissue-reacting igs were bound in vivo to the tissues, as was established by direct treatment of a biopsy of the delto ... | 1978 | 99060 |
| radioimmunoassay for serum myoglobin. | a column flow-through radioimmune assay for serum myoglobin has been developed. the assay uses antibodies to human or rhesus monkey myoglobin coupled to sepharose by cyanogen bromide activation and myoglobin labeled by the chloramine-t method. the labeled myoglobin is stable over two to three half-lives. serum myoglobin levels were elevated when serum was taken up to 12 hours after myocardial infarction and generally elevated up to 24 hours. a continued or repeated elevation of serum myoglobin p ... | 1978 | 99074 |
| [hormonal control of thyroxine-binding globulin synthesis and metabolism (author's transl)]. | serum thyroxine-binding globulin (tbg), the major plasma transport protein for thyroid hormones in man, was shown to be altered under the influence of estrogen and in hypothyroidism. in order to study these alterations, we used an animal model. synthesis of tbg was demonstrated in hepatocytes isolated from adult rhesus monkeys, and in a monkey hepatocarcinoma continuous cell culture line (nclp-6-e). when the hepatocytes were obtained from monkeys pretreated with beta-estradiol (e2), a specific 2 ... | 1978 | 99075 |
| electromyography of craniofacial musculature during oral respiration in the rhesus monkey (macaca mulatta). | 1978 | 99127 | |
| prenatal removal of frontal association cortex in the fetal rhesus monkey: anatomical and functional consequences in postnatal life. | anatomical and behavioral consequences were examined following bilateral or unilateral resections of the presumptive dorsolateral prefrontal cortex in 4 rhesus monkey fetuses at e102 (102nd embryonic day), e104, e106 and e119, with subsequent replacement in utero and delivery at later stages of development. unoperated monkeys of appropriate pre- and postnatal ages served as controls for certain features of morphogenesis and tectogenesis. monkeys given comparable unilateral or bilateral lesions a ... | 1978 | 99206 |
| the course of facial nerve innervation for the levator veli palatini muscle. | the present study was designed to determine the motor nerve pathway of the facial nerve to the levator veli palatini muscle. the experiments were carried out on 10 anesthetized rhesus monkeys. recorded and analyzed were evoked emg responses of the levator veli palatini and the orbicularis oris muscles by electrical stimulation to both the facial nerve and its branch within the cranium. muscle action potentials (m-waves) from the two muscles could be recognized on stimulating the facial nerve at ... | 1978 | 99274 |
| rosette formation of human null lymphocytes with rhesus monkey erythrocytes. | human null lymphocytes which lack b- and t-lymphocyte markers were found to form spontaneous rosettes with uncoated rhesus monkey erythrocytes. rosette-forming null lymphocytes were determined in null lymphocyte-enriched preparations of healthy persons and of patients with lymphoproliferative diseases. quantitative determinations of these rosette-forming lymphocytes and other cells bearing b- or t-cell markers showed that some, and not all, of the null lymphocytes possess this rosette-forming ca ... | 1978 | 99280 |
| the effects of naloxone on behavior maintained by cocaine and heroin injections in the rhesus monkey. | the effects of repeated administration of naloxone on heroin and cocaine self-administration in non-dependent rhesus monkeys were investigated. animals lever pressing for intravenous heroin (6 micron/kg) and cocaine (100 or 200 micron/kg) were treated for 7--10 days with naloxone at a fixed dose prior to each session. low pretreatment doses of naloxone increased rate of responding maintained by herion. the pattern of responding over the 10-day period of treatment with the higher doses of naloxon ... | 1978 | 99296 |
| visual cortex ablation and thresholds for successively presented stimuli in rhesus monkeys: i. orientation. | rhesus monkeys were trained to discriminate gratings of different orientation presented one at a time. the smallest difference they could reliably detect was determined before and after removal of either inferotemporal, foveal prestriate or lateral striate cortex. four animals with inferotemporal lesions had significantly higher thresholds after operation, which did not improve after extensive practice. two monkeys with lateral striate ablation, and 1 out of 3 animals with foveal prestriate lesi ... | 1978 | 99326 |
| lymphocyte isolation, rosette formation, and mitogen stimulation in rhesus monkeys. | over 70% of rhesus monkey peripheral mononuclear cells were isolated on sodium metrizoate-ficoll gradients with greater than 98% purity. rhesus blood contained 47.8% active e, 58.2% total e, and 30.2% eac rosette forming cells. optimal conditions for mitogen studies were determined using phytohemagglutinin, concanavalin a, pokeweed mitogen, lipopolysaccharide and streptolysin o. | 1978 | 99337 |
| sexual behavior of laboratory- and wild-born male rhesus monkeys. | 1978 | 99357 | |
| sero-survey of rhesus monkeys for bacterial and viral antibodies. | 1978 | 99364 | |
| the effect of acetazolamide on cerebral blood flow and oxygen utilization in the rhesus monkey. | the brain is critically dependent for its moment to moment function and survival on an adequate supply of oxygen. the enzyme carbonic anhydrase (ec 4.2.1.1) may play an important role in oxygen delivery to brain tissue by facilitating the hydration of metabolically produced carbon dioxide in erythrocytes in brain capillaries, thus permitting the bohr effect to occur. we examined the effect of 30 mg/kg i.v. acetazolamide, a potent inhibitor of carbonic anhydrase, upon cerebral blood flow and oxyg ... | 1978 | 99455 |
| the hypothalamic magnocellular system of the rhesus monkey: an immunocytochemical study. | the hypothalamic magnocellular system of the adult female rhesus monkey is studied here, using immunoperoxidase technique and antisera to estrogen stimulated neurophysin (esn), nicotine stimulated neurophysin (nsn), oxytocin (ot) and vasopressin (vp). these observations confirm and enlarge previous descriptions by others using gomori techniques. it is apparent from this study that the magnocellular system spreads through a broader area than is generally accepted. a group of cells ventral to the ... | 1978 | 99459 |
| profound hypoxia in papio anubis and macaca mulatta--physiological and neuropathological effects. i. abrupt exposure following normoxia. ii. abrupt exposure following moderate hypoxia. | lightly anaesthetized and spontaneously breathing p. anubis (pa) and m. mulatta (mm) inhaled at ambient pressure 3.2% oxygen (identical to 37,500 ft or 11,430 m) from air and also after pre-exposure to 14% oxygen (identical to 10,000 ft or 3,048 m). the eeg, ecg, respiratory rate, arterial and cerebral venous sinus pressures, end-tidal po2 and pco2 and body temperature were recorded. arterial and cerebral venous sinus blood gases, ph and pyruvate and lactate contents were estimated. before hypox ... | 2001 | 99492 |
| an electron-microscopic analysis of axonal alterations following blunt contusion of the spinal cord of the rhesus monkey (macaca mulatta). | following contusion (500 g-cm) at upper thoracic levels, sections from the spinal cords of 13 rhesus monkeys were examined with the electron microscope. survival times ranged from 4 hr to 10 weeks. samples were taken from the lesion site, from areas 3 and 10 mm rostral and caudal to the lesion center, and from the lumbosacral cord. four hours postoperatively, several small axons located close to the grey matter at the lesion site exhibit abnormal accumulations of organelles including mitochondri ... | 1978 | 99494 |
| the paratrigeminal nucleus. i. neurons and synaptic organization. | the paratrigeminal nucleus, a diffuse collection of neurons on the lateral medullary surface, lies embedded in the fibres of the restiform body, ascending spinocerebellar tract and the spinal tract of the trigeminal nerve. its rostrocaudal extent is approximately 1500--2000 micrometer in the rat, 2800--3500 micrometer in the rhesus monkey, and 5000--6000 micrometer in the human, where it is a well-defined nucleus. in golgi preparations the neuronal somata are generally fusiform, ranging from 8-- ... | 1978 | 99495 |
| the paratrigeminal nucleus. ii. identification and inter-relations of catecholamine axons, indoleamine axons, and substance p immunoreactive cells in the neuropil. | the localization of three different putative neurotransmitters -- indoleamine, catecholamine, and substance p -- was studied in the paratrigeminal nucleus of the rat and rhesus monkey at the light and electron microscope level by autoradiography following administration of [3h]5-hydroxytryptamine, or [3h]norepinephrine, and by immunocytochemistry using the unlabelled anti-substance p antiserum peroxidase--antiperoxidase technique. the paratrigeminal neurons are not monoaminergic but certain cell ... | 1978 | 99496 |
| artificial menstrual cycles, behaviour and the role of androgens in female rhesus monkeys. | 1978 | 99669 | |
| skf 525-a inhibition of hepatic monooxygenase activity in rhesus monkeys. | pretreatment of 3 male rhesus monkeys (macaca mulatta) with skf 525-a(20 mg/kg, i.m.) 3 h prior to to injecting 14ch3-n-antipyrine (30 mg/kg, i.v.) increased antipyrine plasma half-life (aph) 240--500%; measurements of aph made 4, 8 and 11 days after skf 525-a treatment were also higher than control values. increases correspond to decreased plasma levels of 3-hydroxymethylantipyrine and 4-hydroxyantipyrine and decreased rates of aldrin epoxidation in liver biopsy homogenates. comparison of hslc ... | 1978 | 99753 |
| regeneration of skeletal muscle after grafting in monkeys. | twenty-five palmaris longus muscles were transplanted into the forearm (orthotopic autografts) or into the face (heterotopic autografts) in 15 rhesus monkeys. these muscles were transplanted with or without anastomosis to a motor nerve. no significant difference was observed long-term between the grafts done with or without prior denervation of the muscle. the forearm muscle grafts without neurorrhaphies formed a static, fibrous sling which did not contract. the forearm autografts with neurorrha ... | 1978 | 99759 |
| site of action of oestrogens in controlling the release of lh and fsh in the rhesus monkey. | 1978 | 99781 | |
| the effect of ethanol on the metabolism of chronically-administered l-alpha-acetylmethadol (laam) in the rhesus monkey. | the metabolism of 3h-laam was studied in monkeys treated acutely and chronically with 2 mg/kg laam via intragastric catheter three times weekly. from the 15th week, 250 mg/kg ethanol every 2 hours (3g/kg/day) was also administered. this dose of ethanol did not impair the metabolism of laam in monkeys. | 1978 | 99782 |
| processes controlling arm movements in monkeys. | the experiments identify some of the processes underlying arm movements in rhesus monkeys. three monkeys were trained to point to a target with the hand and forearm and to hold that position for about 1 second to obtain a reward. forearm movements were performed without sight of the arm before and after bilateral dorsal rhizotomy. in both intact and deafferented animals, we unexpectedly displaced the forearm prior to movement initiation and observed that the arm moved accurately to the target. t ... | 1978 | 99813 |
| [comparative study of radiation-protective effectiveness of mexamine and gas hypoxic mixture in experiments on rhesus monkeys]. | 1978 | 99900 | |
| pituitary and ovarian hormonal response to 48 h gonadotrophin releasing hormone (gnrh) infusions in female rhesus monkeys. | 1978 | 99938 | |
| histochemical studies on the morphology of the golgi apparatus and its relation to catecholamine biosynthesis in the locus coeruleus of rhesus and crab-eating monkeys. | detailed histochemical studies have been conducted on the distribution of thiamine pyrophosphatase (tppase), l-gulonolactone oxidase (glo), and nad-linked xylitol dehydrogenase (xdh) in every component of the locus coeruleus (lc) of healthy adult male rhesus and crab-eating monkeys in order to clearify the morphology of the golgi apparatus (ga) and its relation to biosynthesis of catechol-amines in this special nucleus of the primate (na nucleus a 6 as defined in the rhesus monkey by german and ... | 1978 | 99950 |
| lumbar spondylectomy in the subhuman primate. | removal of the 2nd or 3rd lumbar vertebrae (or both) has been accomplished in the subhuman primate (macaca mulatta). variations between this animal and the dog in posture, vertebral column anatomy, and spinal cord blood supply made no apparent difference in the results when compared with those in previous experiments. all macaques were able to clinb and to use their hind legs in a normal manner within 3 days after surgical operation. once hair had regrown over the surgical incision, persons not ... | 1978 | 100028 |
| rosette formation by human lymphoid cells with monkey red blood cells. | the present paper describes a study on rosette formation by human lymphoid cells with monkey erythrocytes (mrbc) obtained from two species: african green monkey (cercopithecus aethiops) and rhesus monkey (macaca mulata). all the lymphocyte preparations obtained from peripheral blood, tonsils, thymocytes, bone-marrow and spleen biopsies formed rosettes in variable proportions with erythrocytes obtained from these two monkey species tested. cells of established lymphoblastoid cell lines characteri ... | 1978 | 100044 |
| localization and detection of visual stimuli following superior colliculus lesions in rhesus monkeys. | rhesus monkeys were trained to fixate a central stimulus and to detect and localize a 50 msec light flash presented 6-80 degrees on either side of the central stimulus. following large lesions of the superior colliculus, they showed persistent deficits in localizing flashes presented 43-80 degrees from the fixation stimulus. however, they were not consistently impaired when the flashes were presented more centrally, and their performance with peripheral stimuli improved when the stimulus duratio ... | 1978 | 100175 |
| [animal experimental tests of a new filling material (isocap)]. | an experimental investigation with animals (rhesus monkeys) concerning pulp tolerance to two premeasured dosages of calcium hydroxide cement (reocap and reocap-e) as well as a pre-measured dosage of filling material (isocap) in an injection capsule was carried out (78 class v cavities). as with the negative controls, a very slight reaction, or none at all, developed in response to the two calcium hydroxide cements and the new filling material, with and without application of capping material. wh ... | 1978 | 100305 |
| cerebellar regulation of phonation in rhesus monkey (macaca mulatta). | five rhesus monkeys (macaca mulatta) were trained to emit a "coo" vocalization with a duration of at least 500 msec. after stable performance was achieved cerebellar lesions were introduced, and various pre- and postlesion measures of phonation and of laryngeal emg activity were compared to assess the effects of the lesions. the phonatory changes were interpreted with respect to possible laryngeal or respiratory modifications. the relation between fundamental frequency and intensity of phonation ... | 1978 | 100336 |
| conflicting visual-vestibular stimulation and vestibular nucleus activity in alert monkeys. | in alert rhesus monkeys (macaca mulatta) neuronal activity of vestibular nuclei was recorded during pure vestibular and conflicting visual-vestibular stimulation. pure vestibular stimulation consisted of rotating the monkey about the vertical axis in complete darkness. during conflicting visual-vestibular stimulation the monkeys were rotated in the light within a vertically striped cylinder mechanically coupled to the turntable. the conflict is that although the monkey is accelerated, there is n ... | 1978 | 100338 |
| histochemical localization of cholinesterases in the neural tissue of the pineal in the rhesus monkey. | the neural tissue of the monkey pineal contains both acetyl and butyryl cholinesterases. acetylcholinesterase was localized in the cisternae of the nuclear membrane, rough endoplasmic reticulum, on the plasma membrane of the neurones, and on the axolemma of both non-myelinated and myelinated fibres. the enzyme was not found in the axosomatic or axo-dendritic synapses. it is therefore suggested that the pineal neurones have a cholinergic function rather than a cholinoceptive one. | 1978 | 100342 |
| intercellular junctions in the ciliary epithelium. | the fine structure of the intercellular junctions in the ciliary epithelium of rhesus monkeys and rabbits was studied with conventional electron microscopy of thin-sectioned specimens and the freeze-fracturing technique. in the rhesus monkey, a zonula occludens, zonula adhaerens, gap junctions, and desmosomes interconnect the nonpigmented cells, whereas gap junctions, puncta adhaerentia, and desmosomes connect pigmented to nonpigmented cells, and pigmented cells to one another. in the rabbit, de ... | 1978 | 100466 |
| pigment epithelial windows and drusen: an animal model. | aging rhesus monkeys, both controls and those undergoing long-term administration of investigational oral contraceptive steroids, developed widespread hyperfluorescent dots at the posterior pole. the dots were considered to represent drusen. histologic (including electron microscopic) study showed the "drusen" in some of the animals to be almost exclusively pigment epithelial windows produced by a lipoidal degeneration of the pigment epithelial cells. the experiment provided a fortuitous model f ... | 1978 | 100467 |
| identification of rickettsia rickettsii in formalin-fixed, paraffin-embedded tissues by immunofluorescence. | with slight modification of a trypsin digestion technique, rickettsia rickettsii were demonstrated specifically by immunofluorescence staining in formalin-fixed, paraffin-embedded tissue sections from a human, rhesus monkey, and guinea pig with rocky mountain spotted fever and in infected membranes from a chicken embryo. tissues were cut at 4 micron and, using geltain as a tissue adhesive, were hydrated in a routine manner. sections were then digested in refrigerated 0.1% trypsin for 16 h, washe ... | 1978 | 100509 |
| quantitative multiregional csf kinetics using serial, metrizamide enhanced computed tomography. | two rhesus monkeys studied by serial metrizamide (amipaque) enhanced computer tomography (ct) imaging were used to quantitatively analyze cerebrospinal fluid (csf) kinetics in multiple anatomical regions. time--density curves were generated for the cisterna magna, suprasellar cistern, quadrigeminal cistern, and sylvian fissure, if clinical, biochemical, and routine static ct scanning indicate a profile suggesting normal pressure hydrocephalus, then csf kinetics may be quantitatively and dynamica ... | 1978 | 100534 |
| pharmacokinetics and metabolism of hexachlorobenzene in the rat and the rhesus monkey. | 1978 | 100539 | |
| biliary excretion of diethylstilbestrol in the rhesus monkey. | the biliary excretion of diethylstilbestrol in the bile fistula rhesus monkey was investigated during exogenous taurocholate- and taurodehydrocholate-induced choleresis. following intravenous administration, 36% of the dose was excreted into the bile (as diethylstilbestrol monoglucuronide) and 53% in the urine (as diethylstilbestrol monoglucuronide plus more polar unidentified metabolites). during the steady-state infusion of diethylstilbestrol, with taurocholate-induced choleresis, a bile flow ... | 1978 | 100590 |
| pharmacokinetics of carbamazepine-10,11- epoxide before and after autoinduction in rhesus monkeys. | 1978 | 100595 | |
| identification of endogenous gamma-hydroxybutyrate in human and bovine brain and its regional distribution in human, guinea pig and rhesus monkey brain. | gamma-hydroxybutyric acid (ghb), a compound that has interesting neuropharmacological actions when administered systemically, was shown by means of gas chromatography-mass spectrometry to be present in postmortem samples of human brain in concentrations ranging from 2 to 20 nmol/g. tissue samples from the basal ganglia contained 2 to 3 times as much ghb as tissue samples from cortical regions. the regional brain distribution of ghb was examined in the guinea pig and rhesus monkey and found to pa ... | 1978 | 100596 |
| the effect of dietary crude fiber levels on rhesus monkeys during quarantine. | a study was conducted to determine the effect of dietary crude fiber level on intestinal disorders in the feral rheusus monkey (macaca mulatta) during the first 60 days of the quarantine period. three experimental baked diets containing 2.4%, 7.0%, and 9.8% crude fiber and a commercially extruded diet containing 2.2% crude fiber were fed during the study. the morbidity rate of intestinal disorders at the 7% crude fiber level was 1.4%, which was significantly less (p less than 0.05) than the 11.1 ... | 1978 | 100649 |
| antigenic relationship of two strains of simian hemorrhagic fever virus. | serological comparison of the prototype and an epizootic (corbell) strain of simian hemorrhagic fever virus revealed that the two viruses were serologically similar. the prototype strain differs from the corbell strain in that the latter cannot be cultivated in vitro. serological comparison of the prototype virus grown in tissue culture and its homologous antibody and the prototype and corbell viruses recovered from rhesus monkey serum and their homologous antibodies showed differences and sugge ... | 1978 | 100652 |
| aortic total glycosaminoglycan and dermatan sulfate changes in atherosclerotic rhesus monkeys. | the composition and content of aortic glycosaminoglycans were studied in groups of rhesus monkeys fed control or atherogenic diets for 9 or 19 months. aortic uronic acid content was significantly increased in both groups of monkeys with atherosclerosis. the major glycosaminoglycan in both control and atherosclerotic aortas was chondroitin sulfate with lesser amounts of heparan sulfate, dermatan sulfate, and hyaluronic acid. dermatan sulfate was the only glycosaminoglycan to show a statistically ... | 1978 | 100655 |
| brief communication. comparative pharmacology of norcocaine in m. mulatta and m. fascicularis. | norcocaine was administered intravenously (0.05, 0.5, 5.0 mg/kg) to three chaired unanesthetized male rhesus monkeys and to three chaired male cynomolgus monkeys. respiration rate, heart rate and rectal temperature were monitored. in the rhesus monkeys tachycardia and hyperventilation resulted. however, similar qualitative and quantitative changes were not observed in the cynomolgus species. there was a statistically significant difference in the response to norcocaine across species. these resu ... | 1978 | 100791 |
| annual cycles of aggression and plasma testosterone in captive male rhesus monkeys. | 1978 | 100805 | |
| hypophysial responses to continuous and intermittent delivery of hypopthalamic gonadotropin-releasing hormone. | in rhesus monkeys with hypothalamic lesions that abolish gonadotropic hormone release by the pituitary gland, the constant infusion of exogenous gonadotropin-releasing hormone (gnrh) fails to restore sustained gonadotropin secretion. in marked contrast, intermittent administration of the synthetic decapeptide once per hour, the physiological frequency of gonadotropin release in the monkeys, reestablishes pituitary gonadotropin secretion. this phenomenon is attributable to the pattern of gnrh del ... | 1978 | 100883 |
| toxicology studies of linear alkylbenzene sulphonate (las) in rhesus monkeys. ii. the disposition of [14c] las after oral or subcutaneous administration. | the disposition of radioactivity has been studied after administration of single and repeated oral or subcutaneous doses of [14c] las to rhesus monkeys. after single 30 mg/kg oral doses the radioactivity was rapidly excreted, mostly during the first 24 h. means of 71.2% and 23.1% of the dose were excreted in the urine and faeces respectively during 5 days. similarly, after single 1 mg/kg subcutaneous doses, means of 64.1% and 10.9% were excreted in urine and faeces respectively during 5 days, mo ... | 1978 | 100903 |
| influence of a single blood transfusion on kidney allograft survival in unrelated rhesus monkeys. | a prospective study was performed in moderately immunosuppressed unrelated rhesus monkeys to investigate the influence of a single transfusion on kidney allograft survival. the recipients received either whole citrated blood or plasma-free transfusates consisting of pure red blood cell or lymphocyte suspensions. except for one group, in which blood and kidney donors were optimally matched, transfusions and kidney allografts were disparate for two to four a/b locus antigens with the recipients. t ... | 1978 | 100915 |
| descending monoaminergic pathways in the primate spinal cord. | the distribution of monoamine axons and terminals within the spinal cord of a primate (macaca mulatta) was studied with the falck-hillarp histofluorescence technique for the demonstration of biogenic amines. catecholamine and indoleamine varicosities appeared qualitatively similar to those previously reported for the rat although the indoleamine terminals were difficult to visualize and were not studied in great detail. catecholamine fibers innervate the substantia gelatinosa, marginal layer, in ... | 1978 | 101068 |
| plasma cortisol in the chronic rhesus monkey preparation (macaca mulatta). | the short- and long-term effects of surgical procedures and chair restraint on total plasma cortisol were assessed in the chronic rhesus monkey preparation. three nonpregnant and six pregnant animals were sampled daily, morning and evening. fetal plasma specimens were obtained simultaneously from the pregnant animals. in the nonpregnant rhesus monkey, a circadian rhythm is present the day following venous catheterization and chair restraint, with individual values similar to those in trained, un ... | 1978 | 101086 |
| vasectomy in rhesus monkeys. iv. electron microscopic studies of the seminiferous epithelium. | 1978 | 101096 | |
| sensory discriminability comparisons in human and monkey with implications for the study of central nervous correlates. | psychophysical measurements of sensory discriminability were obtained from rhesus monkeys and humans to suprathreshold electrical cutaneous stimulation by employing a two-choice discrimination task and a signal detection theoretical analysis. sensory discriminatory capacities were found to be similar for monkeys and humans. choice-latency data permitted the construction of relative operating characteristic (roc) functions for both groups. these functions provided similar descriptions of the hypo ... | 1977 | 101114 |
| antimalarial activities of various 9-phenanthrenemethanols with special attention to wr-122,455 and wr-171,669. | pilot appraisals of the activities of 16 specially selected 9-phenanthrenemethanols against acute infections with plasmodium falciparum in owl monkeys showed that all were more active than the reference compound, wr-33,063. wr-122,455, the most active derivative, and wr-171,669, ranked sixth, were selected for study in human volunteers. to assist this undertaking, appraisals of both compounds in owl monkeys infected with various strains of p. falciparum were expanded. these assessments showed: ( ... | 1978 | 101127 |
| metabolism of prostacyclin. oxidation by rhesus monkey lung 15-hydroxyl prostaglandin dehydrogenase. | 1978 | 101144 | |
| gastric antisecretory effects of propantheline bromide and metiamide in rhesus monkeys. | the effects of propantheline bromide (pb) and metiamide (m), two dissimilar classes of gastric secretory inhibitors, were studied in chronic gastric fistula rhesus monkeys. basal and stimulated gastric secretory studies were conducted in conscious monkeys. multiple s.c. injections of either histamine or pentagastrin were given hourly for four consecutive hours. one hour after the injection of the stimulants a constant plateau of gastric secretion was reached, and the test compounds were then adm ... | 1978 | 101158 |
| e.e.g. monitoring for the control of anaesthesia produced by the infusion of althesin in primates. | the continuous infusion of althesin under electroencephalographic (e.e.g.) control provided a constant level of light anaesthesia for periods of 1--5.5 h during experimental brain hypoxia in spontaneously breathing baboons and rhesus monkeys. polygraphic records (respiration, heart rate, arterial pressure, cerebral venous sinus pressure, end-tidal gas concentrations) and also estimation of blood-gas tensions, ph, and concentrations of pyruvate and lactate demonstrated a steady physiological stat ... | 1978 | 101225 |
| effect of psychosocial stimuli and limbic lesions on prolactin at rest and following stress. | many of the factors altering corticosterone in the rat have similar effects on prolactin. resting prolactin, like corticosterone, is higher in animals housed singly than in those multiply housed. unlike corticosterone, gentling did not lower prolactin. an exquisite sensitivity to environmental stimuli which results in rapid elevations in prolactin levels has been indentified in the rat which is considerably greater than that for corticosterone. like corticosterone, the pattern of prolactin stres ... | 1977 | 101322 |
| interceptive activity of azastene in rhesus monkeys. | azastene is an orally effective "luteolytic" agent in rhesus monkeys. in nonpregnant monkeys it reverses the human chorionic gonadotropin-stimulated increase in progesterone production and delay in the onset of menstruation, and, in inseminated monkeys, it prevents pregnancy if given for 5 days beginning on day 24 of the menstrual cycle. the drug is also effective in terminating pregnancy if given for 5 days beginning on approximately day 26, day 50, or day 80 of gestation. concurrent progestero ... | 1978 | 101392 |
| influence of progesterone on sexual behavior in castrated male rhesus monkeys treated with testosterone. | 1978 | 101436 | |
| effect of testosterone propionate on electrical activity of brain in intact & gonadectomized rhesus monkeys. | 1978 | 101442 | |
| mortality of monkeys after exposure to fission neutrons and the effect of autologous bone marrow transplantation. | in order to assess the risk of exposure to ionizing radiation in man, and to evaluate the results of therapeutic measures, the mortality of rhesus monkeys irradiated with x-rays and fission neutrons and the effect of autologous bone marrow transplantation have been investigated. the ld50/30d values for x- and neutron-irradiated monkeys amount to 525 and 260 rad respectively, resulting in an r.b.e. of approximately 2 for the occurrence of the bone marrow syndrome. protection of the animals by aut ... | 1978 | 101475 |
| chronic pyelonephritis. an electron microscopic study in nonhuman primates. | the rhesus monkey (macaca mulatta) proved to be a successful model for the ultrastructural study of ascending nonobstructive pyelonephritis. the most severe kidney damage occurred where the inflammatory response was greatest, and these areas overlaid a dilated or clubbed calyx. the most prominent ultrastructural changes were in the renal tubular cells that showed swollen mitochondria with ruptured inner membranes, dilated endoplasmic reticulum, and flocculent and irregular basal laminae. no reco ... | 1978 | 101481 |
| maternal separations in rhesus monkeys within a social context. | 1978 | 101552 | |
| a study of the effect of slow-reacting substances of anaphylaxis on the rhesus monkey airway. | slow-reacting substance of anaphylaxis (srs-a) generated from rat peritoneal mast cells was aerosolized to the airways of a group of rhesus monkeys with established airway responses to ascaris antigen. a selective effect of srs-a on pulmonary resistance and a lesser but significant effect on compliance was observed which differed from antigen, histamine, carbocholine, or prostaglandin (pg) f2alpha responses. the airway recovery from the pr change is slower than that from histamine and simulated ... | 1978 | 101573 |
| specific change in the direction of prostaglandin synthesis by intra-uterine tissues of the rhesus monkey (macaca mulatta) during late pregnancy. | the rates of production of prostaglandin e (pge), prostaglandin f (pgf) and 13, 14-dihydro-15-oxo-prostaglandin f (pgfm) by intra-uterine tissues from pregnant monkeys in vitro have been determined using a method of tissue superfusion. the amnion, chorion, placenta, decidua basalis, decidua parietalis and myometrium were obtained at caesarean section during late pregnancy. production of pge by all tissues was significantly lower at term than during late pregnancy, whereas production of pgf by th ... | 1978 | 101638 |
| production of thromboxane b2 by the intra-uterine tissues from late pregnant rhesus monkeys (macaca mulatta) in vitro. | the rates of production of thromboxane b2 in vitro by intra-uterine tissues obtained from late pregnant monkeys by caesarean section have been determined. the general quantitative order of rates of production was decidua basalis = decidua parietalis greater than placenta greater than chorion greater than amnion = myometrium. myometrial production of thromboxane b2 was greater at term than during late pregnancy; no other tissue showed a significant trend with advancing gestation. these data demon ... | 1978 | 101641 |
| influences of season and age on maturation in vitro of rhesus monkey oocytes. | oocytes obtained from antral follicles of adult and adolescent rhesus monkeys during the annual breeding season extruded polar bodies in vitro at significantly higher rates (50--60%) than oocytes from animals of similar age during the non-breeding season ((20--30%) or from infant and prepubertal females at any time of the year (20--30%). the proportion of oocytes degenerating in culture was greatest in groups where maturation was highest. | 1978 | 101658 |
| transmission of hepatitis b to the rhesus monkey. studies on the humoral and cell-mediated immune response. | the susceptibility of the rhesus monkey (macaca mulatta) to hepatitis b virus was enhanced by the induction of chronic infection with plasmodium inuei. | 1978 | 101663 |
| blood groups of macaques:a comparative study. | distribution of the human-type and of the simian-type blood groups in rhesus, crab-eating, bonnet, pig-tailed and stump-tailed macaques revealed significant similarities and differences among these species. human-type a--b-o blood groups cut across taxonomic lines and seem less value for taxonomic purposes than the simian-type blood groups detected by cross-reacting isoimmune rhesus monkey sera. | 1978 | 101667 |
| the course of development of glucose intolerance in the monkey (macaca mulatta). | longitudinal studies of the rhesus monkey reveal a syndrome of diabetes mellitus in those that become middle-aged and obese. the sequence of events in the development of the disease progresses from normoinsulinemia with normoglycemia through stages of hyperinsulinemia followed by below normal insulin levels with hyperglycemia and glycosuria. we believe the rhesus to be an excellent nonhuman primate model for maturity-onset diabetes in humans. | 1978 | 101670 |
| gamma hydroxybutyrate in the monkey. iv. dopaminergic mechanisms. | the electrical seizure activity and trancelike state induced in the rhesus monkey by gamma-hydroxybutyrate (ghb) were abolished by dextroamphetamine. dextroamphetamine blockade of this neurophysiologic effect was overcome with chlorpromazine, a dopamine receptor blocker. these results suggest that the electroencephalographic (eeg) and behavioral effects of ghb are related to effects on dopaminergic systems. such a relationship, if substantiated by further studies, might indicate that anticonvuls ... | 1978 | 101898 |
| effects of passive immunization against morphine on heroin self-administration. | antimorphine antibodies produced in rhesus monkeys immunized with morphine-6-hemisuccinate-bsa were passively administered to recipient monkeys trained to self-administer heroin and cocaine. following antibody administration, changes in heroin self-administration behavior were observed which were similar to those achieved with low doses of naloxone. both manipulations increased heroin self-administration without affecting cocaine responding. | 1978 | 101989 |
| short-term memory in the rhesus monkey: effects of dopamine blockade via acute haloperidol administration. | the effects of dopaminergic blockade on recent or short-term memory (stm) were evaluated in test-sophisticated rhesus monkeys. each monkey was tested under several doses of the antidopaminergic haloperidol (0.006 to 0.05 mg/kg), in an automated, delayed-response procedure. the same procedure and test apparatus had previously been used to demonstrate profound stm impairments in aged rhesus monkeys and strikingly similar deficits in young monkeys given the anticholinergic scopolamine. the results ... | 1978 | 101990 |
| a sensitive radioimmunoassay for 6-keto-prostaglandin f1alpha: preliminary observations on circulating concentrations. | a radioimmunoassay for 6-keto-prostaglandin f1alpha (6-keto-pgf1alpha) is reported. the mean least detectable mass of 6-keto-pgf1alpha is 1.45 pg and the mean mass of added 6-keto-pgf1alpha required to displace zero-point binding by 50% is 94.2 pg. cross-reactivities of the antiserum with all the prostaglandins and related compounds tested are less than 0.1% except for pge2 and pgf2alpha which are respectively 0.16% and 0.80%. the assay is both accurate and reproducible and measured levels are i ... | 1978 | 102000 |
| neuronal plasticity in primate telencephalon: anomalous projections induced by prenatal removal of frontal cortex. | when the dorsolateral prefrontal cortex in one hemisphere of a rhesus monkey is resected 6 weeks before birth and the fetus survives to postnatal ages, neurons of the corresponding cortex in the intact hemisphere issue a greatly expanded projection to the contralateral caudate nucleus in addition to a normal projection to the ipsilateral caudate. the enhancement of the crossed prefronto-caudate pathway after prenatal neurosurgery provides direct evidence for lesion-induced neuronal rearrangement ... | 1978 | 102031 |
| trichomonal granuloma of the pelvic cavity in a rhesus monkey. | 1978 | 102073 | |
| experimental group b streptococcal infection in the rhesus monkey. i. disease production in the neonate. | group b streptococci (gbs) are responsible for serious infections of newborn infants. an experimental model for gbs infection was developed in the newborn rhesus monkey in order to obtain more information concerning the pathogenesis of such infections. a series of 29 newborn monkeys were inoculated with either type ic or type iii gbs or sterile broth. fatal neonatal meningitis without associated pneumonia was produced consistently following intracerebral inoculation with either type ic or type i ... | 1978 | 102197 |
| neural control of gonadotropin secretion in primates. | in the rhesus monkey, there is abundant evidence to indicate that ovarian secretions, mainly estradiol-17beta, control "tonic" as well as "cyclic" secretion of gonadotropins during the menstrual cycle. this mechanism of control ensures coordination of ovarian morphology and anterior pituitary secretory patterns. the primary site of action of estradiol in controlling both "tonic" and "cyclic" secretion of gonadotropins has been circumscribed to the medial basal hypothalamic-pituitary unit. a modu ... | 1978 | 102199 |
| metric characteristics of the canine dental complex in prenatally androgenized female rhesus monkeys (macaca mulatta). | permanent maxillary canine teeth (c1) are appreciably larger in males than in females in most nonhominid anthropoidea. mandibular canines (c1) and mandibular first premolars (p3), against which c1 are sharpened in honing behavior, reflect commensurate sexual dimorphism. these three teeth constitute the canine dental complex. the canine complex crown metrics of seven mature genetically female rhesus macaques, androgenized by prenatal exposure to testosterone propionate, were compared with a contr ... | 1978 | 102208 |
| a quantitative estimation of the depletion of the granules of argyrophile cells in the gastrointestinal tract of reserpine treated rhesus monkeys. | the depletion of the granules of argyrophile cells following administration of reserpine has been studied at various levels of the gastrointestinal tract of the rhesus monkey. granulation of the cells has been estimated by the photometric method of singh(1976). the argyrophile cells that persist after reserpine administration show a statistically significant reduction in their granulation as compared to cells of untreated controls (p less than 0.001). | 1978 | 102216 |
| spermatophagy in the seminiferous tubules and excurrent ducts of the testis in rhesus monkey and in man. | the fine structure of cells capable of phagocytosing spermatozoa in the testes and epididymes of monkeys and men was studied by means of transmission and scanning electron microscopy. both resident cells, such as sertoli cells and epithelia of the rete testis, and free cells, such as macrophages (spermatophages) were found to phagocytose spermatozoa or fragments of spermatozoa in the seminiferous tubules and excurrent ducts. the spermatophages develop from precursor cells which invade the semini ... | 1978 | 102218 |
| distribution of tissue water and electrolytes in normal rhesus macaques. | techniques for the determination of water and electrolytes in individual tissues of normal rhesus macaques (macaca mulatta) are described. base-line values are presented for intracellular and extracellular distributions of water and electrolytes in 14 tissues, including skin, skeletal muscle (gastrocnemius), cardiac muscle (left ventricle), lung, diaphragm, liver, renal cortex, outer medulla and inner medulla, cerebral cortex, cerebellum, thalamus-hypothalamus complex, medulla oblongata, and spi ... | 2000 | 102224 |
| a behavioral analysis of complete unilateral section of the pyramidal tract at the medullary level in macaca mulatta. | ten macaca mulatta monkeys were operantly conditioned to perform three motor paradigms designed to evaluate single and combination finger movements. eight of these monkeys were retested after left medullary pyramidotomy; 2 monkeys underwent left medullary pyramidotomy prior to conditioning. all animals were tested for three years after operation. monkeys with a completely sectioned medullary pyramid could, with time, perform difficult motor paradigms that required: (1) both individual and combin ... | 1978 | 102241 |
| semi-automated detection of emesis in the rhesus monkey. | the use of a video recorder and the inclusion of a marker dye in material fed to rhesus monkeys has eliminated the need for the constant presence of an observer to detect an emetic response. | 1978 | 102332 |
| influence of ovarian hormones on prolactin release in the rhesus monkey. | 1978 | 102374 | |
| chemical occlusion of rhesus monkey oviducts with chloroquine. | fertility control through chemical occlusion of the oviducts with chloroquine was investigated in rhesus monkeys (m.m.). chloroquine was instilled retrograde through the tubal ostium after laparotomising the monkeys as a 10, 50 and 100% suspension (w/v) in aqueous carboxymethyl cellulose (cmc) solution which was used as a carrier vehicle. complete occlusion of the fallopian tubes at the uterotubal junction and also the intramural portions resulted in 15 days after a single instillation. | 1978 | 102485 |
| [goal-directed behavior of experimental monkeys (macaca mulatta) defined by the relative novelty of the experimental situation]. | 1978 | 102506 |