Publications
| Title | Abstract | Year Filter | PMID(sorted ascending) Filter |
|---|
| tess line: a laboratory line of the musk shrew (suncus murinus, insectivora), triple-homozygous for the curly hair (ch), cream coat-color (cr) and red-eyed dilution (rd) genes and segregating the sucrase deficients (suc/suc). | the tess line, the first tester line of the suncus has been developed. the tess shrews are homozygous for three morphological mutant genes, ch, cr and rd. the gene (suc) for sucrase activity deficiency in intestinal brush-border membranes also exists in the line, and its frequency was 34.3%. the deficients could easily be identified by the drastic body-weight losing up to more than 15% of the initial weight, that aroused two days after replacement of the drinking water for its 10%-sucrose soluti ... | 1994 | 8119332 |
| adenosine induces contractions in suncus ileum. | purinoceptor-mediated responses were characterized in the ileum of suncus murinus. adenosine as well as adenosine 5'-triphosphate (atp) contracted the ileum in a concentration-dependent manner. contractile responses to transmural electrical stimulation were attenuated by adenosine only at high concentrations. theophylline competitively blocked the adenosine-induced contraction. atropine also inhibited the adenosine-induced contraction but in a non-competitive manner. the atp-induced contraction ... | 1993 | 8121076 |
| activities of drug-metabolizing enzymes in the liver of suncus murinus: possible lack of n-acetyltransferase activity in liver cytosol. | the amounts of several drug-metabolizing enzymes in livers of suncus murinus (suncus) were studied in comparison with rats. the content of cytochrome p450 in suncus was less than one third that seen in rats. activities of glutathione s-transferase, udp-glucuronyltransferase and arylhydroxycarbon hydroxylase in suncus were less than half those in rats. activity of flavin-containing monooxygenase in suncus was 71% that of rats. interestingly, n-acetyltransferase (nat) activity in suncus liver cyto ... | 1994 | 8153148 |
| distribution and steroid dependence of aromatase enzyme immunoreactivity in limbic nuclei of the female musk shrew brain. | in the female musk shrew (suncus murinus) neural aromatization of testosterone to estradiol is critical for the expression of sexual behavior. to localize the brain regions capable of aromatization, we used immunocytochemistry to map the distribution of aromatase enzyme. aromatase immunoreactivity (arom-ir) has a discrete distribution primarily limited to the lateral septum (ls), central nuclei of the amygdala (ce) and the bed nucleus of the stria terminalis (bst). in these nuclei the intensity ... | 1994 | 8156384 |
| effects of iron and deferoxamine on cisplatin-induced emesis: further evidence for the role of free radicals. | the effects of ferric chloride and deferoxamine, an iron chelator, on cisplatin-induced emesis were studied in suncus murinus. pretreatment with ferric chloride (fecl3, 16-64 mg/kg) increased the number of 20 mg/kg cisplatin-induced vomiting episodes. deferoxamine (256 mg/kg) significantly reduced the number of vomiting episodes and prolonged the latency. these results further support the involvement of free radicals in the generation of cisplatin-induced emesis. | 1993 | 8181539 |
| distinctive features of the gametes and reproductive tracts of the asian musk shrew, suncus murinus. | insectivora are of special interest as the most primitive of the eutherian mammals, but essentially nothing is known of their gamete function. in this respect, the asian musk shrew (suncus murinus), investigated in the present study, displays many idiosyncrasies. in the epididymis, the giant acrosome undergoes further stabilization, its unusual resilience being especially evident in a "rim" created by a persistent close alignment of the outer acrosomal and overlying plasma membranes. however, un ... | 1994 | 8199263 |
| identification of hairs of three asian commensal mammals: suncus murinus, bandicota bengalensis, and rattus exulans. | hairs of 3 major asian commensal mammals, suncus murinus (l.), bandicota bengalensis (gray and hardwicke), and rattus exulans (peale), were studied, identified, and compared with those of better-known commensal species to provide an overview of their hair morphologies. techniques were developed for authentic hair specimen collection and rapid slide mounting to aid in the timely analysis of food products. the study showed that hairs of b. bengalensis and r. exulans are easily identified to the re ... | 1994 | 8199475 |
| oxygenation of unsaturated fatty acids by hepatic microsomes of musk shrew (suncus murinus). | the cytochrome p-450-dependent monooxygenase in musk shrew (suncus; suncus murinus) liver microsomes metabolized unsaturated fatty acids (oleic, linoleic, alpha-linolenic and arachidonic acids) to a variety of oxygenated products. alpha-linolenic acid was the most active substrate. the oxygenation activity increased with an increase in the number of cis double-bonds in the c18 fatty acids. this suggests that the introduction of cis double-bonds in c18 fatty acids is important for the binding of ... | 1994 | 8205390 |
| effect of starving and refeeding on lipid metabolism in suncus. | we have previously reported that fatty liver is easily induced in a novel experimental animal, suncus murinus (suncus) by withholding food, and that apolipoprotein b (apo b) is not actively synthesized in the liver. in the present paper we describe the effect of starving and refeeding on lipid and lipoprotein metabolism in suncus, in order to explore the mechanisms of induction of fatty liver by starving and of its improvement by refeeding. starvation induced increase in triglyceride content and ... | 1994 | 8206866 |
| involvement of free radicals in cisplatin-induced emesis in suncus murinus. | the participation of free radicals in cisplatin-induced emesis was investigated in the house musk shrew, suncus murinus. thiobarbituric acid (tba) values, which indicate the degree of lipid peroxidation, in brain, liver and small intestine were increased significantly 60 min after the treatment with cisplatin (20 mg/kg, i.p.). moreover, cisplatin (20 mg/kg, i.p.)-induced emesis was prevented by intraperitoneal injection of n-(2-mercaptopropionyl)glycine (mpg), a radical scavenging agent, with id ... | 1993 | 8223958 |
| presence and differential distribution of distinct forms of immunoreactive gonadotropin-releasing hormone in the musk shrew brain. | gonadotropin-releasing hormone (gnrh) immunoreactive cells and fibers were revealed in olfactory regions, the ventral forebrain, and in the midbrain of the musk shrew (suncus murinus). immunoreactive neurons in olfactory and telencephalic areas were specific for the mammalian form of gnrh. cell bodies in the midbrain, however, cross-reacted with an antibody specific for chicken-ii gnrh. high-performance liquid chromatography and radioimmunoassay analyses confirmed these results; high levels of c ... | 1993 | 8264863 |
| blood supply to the cranial venae cavae and the heart in the laboratory shrew (suncus murinus). | the blood supply to the cranial venae cavae on both sides and to the heart was studied macroscopically in 40 adult laboratory shrews (suncus murinus) of both sexes injected either with neoprene latex into the abdominal aorta (25 animals) or with mercox into the left ventricle (15 animals). the 1st branch of the left subclavian artery in 23 animals of the 1st group ramified caudal to the aortic arch and descended between the aorta and the trachea to supply mainly the large left cranial vena cava ... | 1993 | 8300430 |
| characterization of mycoplasma strains isolated from house musk shrews (suncus murinus) and their infectivity in mice and rats. | five mycoplasma strains isolated from house musk shrews (suncus murinus) in the central institute for experimental animals were characterized and compared with three murine mycoplasma strains, mycoplasma pulmonis m 53, m. arthritidis pg6, and m. neurolyticum type a, and with reference strain g3-5 previously isolated from a house musk shrew. these isolates fermented glucose, but did not hydrolyze urea and arginine, passed through membrane filters of 450 nm pore size, were sensitive to digitonin, ... | 1993 | 8354358 |
| [fine structure of the vomeronasal organ in the house musk shrew (suncus murinus)]. | fine structure of the vomeronasal organ (vno) was examined in an insectivore, house musk shrew (suncus murinus), from a viewpoint of comparative anatomy. the vno was a pair of tubular structure, about 6mm in length, and situated at the base of the nasal septum. the medial wall of the lumen of the vno was lined with the sensory epithelium (se) consisting of sensory, supporting and basal cells, while the respiratory epithelium (re) lining the lateral wall was pseudostratified and covered with micr ... | 1993 | 8354364 |
| [lectin histochemical studies on the musk gland in the house musk shrew (suncus murinus)]. | the musk gland of the adult house musk shrews (suncus murinus) of both sexes was studied lectin histochemically. the musk gland was a kind of scent gland, consisted of congregation of branched or unbranched simple tubuloalveolar gland holocrine in nature and was attached by an apocrine gland-like structure (sweat gland) in the deeper layer of its periphery. acinar cells of the musk gland were distinguishable into three type from basal to luminal parts of the acinus; immature cells, mature cells ... | 1993 | 8354366 |
| x-irradiation-induced emesis in suncus murinus. | x-irradiation-induced emesis was investigated in suncus murinus, a house musk shrew. whole body x-irradiation caused emesis, and the calculated ed50 value that induced emesis in 50% of animals was 429 cgy. at the irradiation dose of 800 cgy all the animals vomited 10.0 +/- 2.4 times with a latency of 20.0 +/- 2.9 min. the emetogenic effect of x-irradiation was dependent on the part of the body exposed. abdominal x-irradiation at 1000 cgy caused emesis in all animals studied, whereas the same dos ... | 1993 | 8360859 |
| characterization of serum lipoproteins from suncus: a candidate animal model for abetalipoproteinemia. | we have previously reported that fatty liver was induced in a novel experimental animal, suncus murinus (suncus), by 24-h fasting and that apolipoprotein b (apo b) was not actively synthesized in the liver. however, a faint signal of apo b mrna was detected in the liver, suggesting possible synthesis of apo b. small amounts of vldl and ldl have been separated from suncus serum by ultracentrifugation. electron microscopic study of the lipoproteins revealed the existence of small particles in vldl ... | 1993 | 8370676 |
| esophageal carcinoma in house musk shrews, suncus murinus (insectivora), induced by n-methyl-n'-nitro-n-nitrosoguanidine. | female 6-week-old shrews were given a solution of n-methyl-n'-nitro-n-nitrosoguanidine (mnng) at a concentration of 50 micrograms/ml or 100 micrograms/ml in the drinking water. all 11 shrews receiving 100 micrograms/ml mnng died 8-13 days after the beginning of carcinogen administration and 6 of the 20 shrews receiving 50 micrograms/ml mnng died after 10-54 days. when animals were between 43 and 54 weeks of age, multiple esophageal lesions were evoked in all 14 that had received 50 micrograms/ml ... | 1993 | 8408184 |
| embryonic development of the house shrew (suncus murinus). ii. embryos at stages 11 and 12 with 13 to 29 pairs of somites, showing limb bud formation and closed cephalic neural tube. | the embryonic development of the laboratory house shrew (suncus murinus) was observed during the period from 13 to 29 pairs of somites and was compared with that of other mammalian species. this period ranged from 10 to 12 days after fertilization. embryos were allocated to stages 11a-c and 12a-c according to somitic count. these embryos were characterized by the following features. 1. the curvature of the body became gradually enhanced, changing from a parenthesis-like to a bracket-like shape. ... | 1993 | 8430900 |
| [diurnal rhythms in locomotor activity of the house musk shrew, suncus murinus]. | a diurnal rhythm of locomotor activity in male and female house musk shrews (jic:sun) aged approximately one year was observed under a schedule of 12 hr light and 12 hr darkness (light on at 07:00) over a period of 10 days. in general, the pattern of locomotor activity was similar in both sexes, with around 24-hr diurnal rhythm. a few typical patterns of locomotor activity in these animals were as follows: a. locomotion interval was close in the light phase, while was sparse in the dark phase. b ... | 1993 | 8462628 |
| [innervation of the external ear in humans and the musk shrew]. | the external ear appears only in mammals and possesses a great diversity of forms. in addition, multiple nerves are distributed in the external ear. the nerves which are distributed in the external ear were investigated in humans and in the musk shrew (suncus murinus) in a macroscopic study. the following results were obtained. cranial nerves (cn) v, vii, x and cervical nerves supply the auricle and the external meatus in both humans and the musk shrew. branches of the third division of cn v sup ... | 1993 | 8463885 |
| comparison of nucleotide sequences from upstream of the dq52 gene to the s mu region of immunoglobulin heavy-chain gene loci between suncus murinus, mouse and human. | the nucleotide sequence of a 4621 base pair fragment of dna, from a position upstream of dsq52 to the s mu region within immunoglobulin heavy-chain gene loci of suncus murinus was determined. the sequence contained one d gene, three jh genes and an enhancer. suncus murinus is an insectivore and is one of the most primitive mammals. both primates and rodents are thought to have originated from insectivores and to have evolved separately. we also determined the nucleotide sequence of a region betw ... | 1993 | 8464428 |
| co-existence of gonadotrophins (fsh, lh) and thyrotrophin (tsh) in single anterior pituitary cells of the musk shrew, suncus murinus. | according to recent immunocytochemical studies of anterior pituitary cells, it is obvious that the "one cell-one hormone" theory must be modified. many pituitary morphologists have demonstrated that there are some cells that contain two hormones. in this study, we demonstrate by means of immuno-electronmicroscopy the co-existence of gonadotrophins (fsh and lh) and thyrotrophin (tsh) in the same anterior pituitary cells of the musk shrew. these cells were remarkably altered in their ultrastructur ... | 1993 | 8513484 |
| muscle study of the musk shrew (suncus murinus riukiuanus). i. gluteal and thigh muscles. | the gluteal and thigh muscles of the musk shrew (suncus murinus riukiuanus) were macroscopically studied. the sartorius was not observed in any of the specimens examined. the gracilis was divided into two bellies. the semitendinosus had two heads of origin, the ischial and vertebral. however, most of the gluteal and thigh muscles of this animal were quite similar with respect to origin, insertion, and also nerve supply to those muscles of rodents and primates, including human beings. all the glu ... | 1993 | 8517115 |
| emetic responses of sorex unguiculatus. | we have shown previously that suncus murinus, a species of the insectivore, can vomit in response to various emetogenic stimuli. in the present study we investigated whether or not sorex unguiculatus, which belongs to different subfamily (soricinae) of insectivore, vomits in response to emetogenic drugs. subcutaneous injection of veratrine and oral administration of copper sulfate caused emesis in the animal. histological study showed that bilateral structure of the area postrema was not importa ... | 1993 | 8519299 |
| distribution of taste buds on the epiglottis of the rat and house shrew, with special reference to air and food pathways. | we investigated the positioning of the epiglottis in the pharyngo-laryngeal region and the distribution of taste buds on the epiglottis in the rat and house shrew, animals which have different feeding habits. in the fixed samples of both species, when the mouth was closed or slightly opened, the epiglottis was found to protrude into the nasopharyngeal hiatus above the soft palate. but it retracted from its position when the mouth was widely opened. in omnivorous rats (n = 6), the mean number (me ... | 1995 | 8559556 |
| experimental models for carcinogenesis in the house musk shrew, suncus murinus, insectivora. | animal carcinogenicity studies have mainly been performed on rodents. from the phylogenetic point of view, animals closer to humans must be included in these studies. insectivora are considered to be the most primitive placental mammals and much closer to the early primates than rodents. among the insectivora, the house musk shrew (suncus murinus, family soracidae), has been bred under laboratory condition. this animal is small having a short life span, and a comparatively low incidence of spont ... | 1995 | 8573996 |
| marked depression of radiation-induced emesis by olfactory bulbectomy or pre-exposure using low doses. | acute emetic response to relatively low-doses of x-irradiation on suncus (suncus murinus) was examined. the behaviors recorded for each subject, using a video-cassette recorder system, were (1) the number of emesis, during exposure to a dose of 3.0 gy; (2) emesis threshold. results showed that the emetic threshold was observed at 0.85 gy, and the number of radioemesis during exposure was 29. however, the observed threshold dose became 2.22 gy following olfactory bulbectomy. the emetic number dec ... | 1996 | 8631391 |
| development of a laboratory colony of the musk shrew (suncus murinus, insectivora) exhibiting a high incidence of spontaneous diabetes mellitus. | 1996 | 8699804 | |
| [parasitic infections among wild rats from two areas of kaohsiung]. | wild rats including four strains were captured for examination of parasitic infections. the numbers were 101 from areas of kaohsiung harbor and 98 from areas of kaohsiung airport. most of the examined wild rats were rattus norvegicus and second most were suncus murinus. the infection rates of intestinal helminths in rats of both areas did not display any significant difference. the overall infection rate was 29.6%. the infection rate was highest in r. norvegicus and the most frequently found par ... | 1996 | 8709181 |
| presence and structure of anal and vaginal tonsils in the laboratory shrew (suncus murinus). | in all the laboratory shrews (suncus murinus) examined, a pair of tonsil-like structures was found at the boundary between the anus and the ostium urogenitoanalis. moreover, the same tissues were recognized between the vagina and the ostium urogenitoanalis in 9 of the 13 females examined. they indicated clear epitheliolymphocyte symbiosis around both mucosal crypts (anal and vaginal crypts) and outer lymph nodules including the germinal centers, and were demarcated from other tissues by the fibr ... | 1996 | 8712373 |
| the broad-spectrum anti-emetic activity of the novel non-peptide tachykinin nk1 receptor antagonist gr203040. | 1. following our earlier observations that the tachykinin nk1 receptor antagonist cp-99,994 is an effective anti-emetic in ferrets, we have examined the anti-emetic effects of a more potent and novel nk1 receptor antagonist, gr203040, against various emetic stimuli in the ferret, dog and house musk shrew (suncus murinus). 2. in ferrets, gr203040 (0.1 mg kg-1 s.c. or i.v.) is effective against emesis induced by radiation, cisplatin, cyclophosphamide, copper sulphate, ipecacuanha or morphine. 3. i ... | 1995 | 8719790 |
| enantiospecific inhibition of emesis induced by nicotine in the house musk shrew (suncus murinus) by the neurokinin1 (nk1) receptor antagonist cp-99,994. | effects of the nk1 receptor antagonist cp-99,994 on nicotine-induced emesis were examined in suncus murinus. cp-99,994 (3 and 10 mg/kg i.p.) attenuated emesis to (-)nicotine (4 mg/kg s.c.). cp-100,263 (3 and 10 mg/kg i.p.), the enantiomer of cp-99,994 with 1000 fold lower affinity for the nk1 receptor was without effect and rp67580 reduced emesis only at a dose of 30 mg/kg i.p. responses to nk1 antagonists were ranked according to their affinities for the suncus murinus nk1 receptor. | 1995 | 8788968 |
| prevalence of rat fleas in and around delhi (india) area and their susceptibility status to insecticides. | a rapid survey in delhi and surrounding areas was undertaken in september 1994, during plague outbreak in district beed (maharashtra) and surat (gujarat) to monitor rodent/flea population and to determine susceptibility status of fleas to insecticides. the five rodent species in order of their prevalence were rattus rattus (86.06%), mus musculus (15.33%), suncus murinus (2.47%), bandicoota indica (0.48%) and b. bengalensis (0.48%). two flea species, xenopsylla cheopis and x. astia, were captured ... | 1996 | 8806038 |
| liver apoptosis after dimethylnitrosamine administration in shrews. | female house musk shrews (suncus murinus, insectivora) were given a single i.p. dose of 30 mg/kg dimethylnitrosamine (dmn) at 8 weeks of age which was lethal 36 to 48 hrs after dosing. liver tissues were collected from shrews killed 3, 6, 16, 24 and 36 hrs after treatment, and the sequential development of the lesions was characterized. dmn induced acute centrilobular cell injury. in 6 hrs, a few cells became apoptotic in the centrilobular area; the number increased at 16 hrs and 24 hrs, and was ... | 1996 | 8811299 |
| the pharmacology of the emetic response to upper gastrointestinal tract stimulation in suncus murinus. | this paper is the first to describe aspects of the mechanics of retching in the insectivore suncus murinus (house musk shrew) and in an animal of such a small size (approximately 50 g). in anaesthetised animals using the novel stimulus of mechanical stimulation of the upper gastrointestinal tract as the provocative stimulus the frequency of retching was found to be about 4 retches/s, a much higher frequency than in other species (dog, cat, ferret). these studies show that quantification of retch ... | 1996 | 8836619 |
| hair growth and skin in the kinky-coat (kc) musk shrew, suncus murinus. | hair growth and skin structure were examined in kinky coat (kc) musk shrews, suncus murinus. the first hair growth cycle and the development of hair bulbs were normal. histological characteristics of hair follicles and bulbs were similar in kc/kc and normal +/kc shrews. the mean thickness of epidermis and dermis did not differ significantly between the kc/kc and +/kc shrews. and no histological abnormalities were observed in the epidermis, dermis and hypodermis of the kc/kc shrews. consequently, ... | 1996 | 8840138 |
| the anti-emetic activity of gk-128 in suncus murinus. | in suncus murinus, various emetic responses and the anti-emetic activity of a new 5-hydroxytryptamine3 (5-ht3) receptor antagonist, gk-128 (2-[(2-methylimidazol-1-yl) methyl benzo[f]thiochromen-1-one monohydrochloride hemihydrate), were investigated. cancer chemotherapeutic agents, cisplatin and cyclophosphamide, dose-dependently induced emesis of long-lasting duration. the 5-ht3 receptor agonist, 2-methyl-5-ht, and copper sulfate also induced emesis of short duration. however, another 5-ht3 rec ... | 1995 | 8846809 |
| chemical features of monoaminergic and non-monoaminergic neurons in the brain of laboratory shrew (suncus murinus) are changed by systemic administration of monoamine precursors. | 5-hydroxy-l-tryptophan (5-htp) and l-3,4-dihydroxyphenylalanine (l-dopa) were injected intraperitoneally (i.p.) into the laboratory shrew (suncus murinus). immunocytochemical and immunofluorescence studies were carried out on serial or same sections of the brain, which were reacted with specific antisera to dopamine (da) or serotonin (5-ht) produced in our laboratory. we observed that cell bodies and nerve terminals of many catecholaminergic (canergic) neurons exhibited 5-htp uptake and conversi ... | 1995 | 8848292 |
| developmental pattern of axonal pathways in the house shrew maxillary nerve. | the topographic patterns of peripheral receptors and effectors seem to contribute to the construction of the neuronal circuit in the central nervous system (cns) in mammals. many patterns replicating those of the periphery have been found in the cns, and fasciculation has been regarded as having a central role in the pattern replication. the house shrew, suncus murinus, is an excellent species in which to study this topic because it has a vibrissae system arranged in a single ordered fashion and ... | 1996 | 8849667 |
| [mechanisms of cytotoxic drug-induced emesis and its prevention]. | in this review, i have attempted to provide an overview of the pathways by which cytotoxic drugs induce emesis. the mechanisms of serotonin 5-ht3 antagonists and new antiemetics are also discussed. old data especially from the experiments employing area postrema ablation must be re-evaluated because it is likely that the operation has damaged other important nucleus in the brain stem. therefore, the concept of the chemoreceptor trigger zone and "vomiting center" proposed by borison et al. in 195 ... | 1996 | 8855716 |
| prophylactic effect of serotonin uptake inhibitors against motion sickness in suncus murinus. | the prophylactic effect of serotonin uptake inhibitors, imipramine and fluoxetine, against motion sickness was investigated in suncus murinus. imipramine (s.c.) and fluoxetine (i.p.) inhibited motion-induced emesis dose dependently with id50 values of 1.7 and 26 mg/kg, respectively. the results suggest that increasing the concentration of serotonin in the synaptic cleft can prevent motion-induced emesis and that serotonin uptake inhibitors are effective as anti-motion sickness drugs. | 1996 | 8864690 |
| gr205171: a novel antagonist with high affinity for the tachykinin nk1 receptor, and potent broad-spectrum anti-emetic activity. | it has been demonstrated recently that antagonists of the tachykinin nk1 receptor, specifically cp-99,994 and gr203040, possess anti-emetic activity in a range of species. to optimise this activity, a series of analogues based around the structure of gr203040 have been synthesised and their affinity at the human tachykinin nk1 receptor determined. in addition, the potency of these analogues to inhibit emesis induced in the ferret by whole-body x-irradiation has been examined. a range of substitu ... | 1996 | 8876035 |
| seroepidemiology of hantaan virus infection in taiwan. | in order to investigate the infection rate of hantaan virus in taiwan, a total of 6,536 human serum samples were collected from residents, selected by stratified random sampling, from 19 townships covering four different ethnic groups: aborigines, fukien taiwanese, hakka taiwanese, and mainland chinese. serum samples were screened for hantaan virus antibodies by indirect immunofluorescence. the prototype hantaan virus (76/118)-infected vero e6 cells were used as the viral antigen for the antibod ... | 1996 | 8950687 |
| distribution of alpha- and beta-subunits of glycoprotein hormones in thyrogonadotroph in the anterior pituitary cells of the musk shrew (suncus murinus). | in order to examine the distribution pattern of alpha- and beta-subunits of glycoprotein hormones in small and large granules in the thyrogonadotrophs of the musk shrew, we used an antiserum against a synthesized peptide consisting of the sequence 37-53 of the rat alpha-subunit, which is highly conservative among several mammalian species, and also antisera to lh beta, fsh beta and tsh beta. both alpha- and lh beta-subunits were colocalized in what appeared at the light-microscopic level to be t ... | 1996 | 8993627 |
| ethanol-induced emesis in the house musk shrew, suncus murinus. | ethanol-induced emesis were investigated using suncus murinus and the emetogenic mechanisms of ethanol were compared with those of cisplatin. intraperitoneal injection of ethanol caused dose-dependent emesis with ed50 value of 22.3% (v/v) when injection volume was adjusted to 4 ml/kg. intraperitoneal and subcutaneous injection of acetaldehyde also caused dose-dependent emesis (ed50 = 3.5% (v/v) with an extremely shorter latency (6% i.p.: 1.0 +/- 0.3 min cf. 40% ethanol: 13.0 +/- 1.9 min). neithe ... | 1997 | 9010480 |
| robertsonian chromosomal variation in the house musk shrew (suncus murinus, insectivora:soricidae) and the colonization history of the species. | a high-resolution g-banding technique was used to identify five metacentrics that characterize suncus murinus from sri lanka. these metacentrics were shown to be the product of robertsonian fusion of acrocentric chromosomes identical to those in the standard karyotype defined by m.b. rogatcheva et al. two of the metacentrics in the sri lankan shrews (rb(10.12) and rb(14.15)) were the same as those reported by c.h. sam et al. in malayan populations of s. murinus. this finding provides strong supp ... | 1997 | 9061910 |
| opposite effects of isoniazid and fasting on the expression of cyp2e1 protein and mrna in house musk shrew (suncus murinus). | the effects of isoniazid and fasting on hepatic cyp2e1 in the suncus were investigated. aniline hydroxylation and n-nitrosodimethylamine demethylation, which are known to be catalyzed by cyp2e1, in liver microsomes were induced and suppressed by the treatment with isoniazid and the fasting, respectively. immunoblot analysis indicated that cyp2e1 protein in liver microsomes from isoniazid-treated suncus was increased in contrast to the result with the fasting of the suncus. northern blot analysis ... | 1997 | 9063569 |
| laboratory suncus: a new model animal for tonsil research. | palatine and tubal tonsils of normal and horseradish peroxidase (hrp) sensitized laboratory suncuses (suncus murinus) were examined by immunoelectron microscopy. the individual tonsil consisted of lymphoepithelial symbiosis containing m cells and a lymph nodule. the high-endothelial venules and efferent lymphatics were situated in the parafollicular region of the nodule. staining of the frozen tonsil sections by our recently developed anti-suncus t and b lymphocyte monoclonal antibodies revealed ... | 1996 | 9082781 |
| preference of lymphocyte-homing to high endothelial venules in palatine tonsils of musk shrew (suncus murinus). | we studied the lymphocyte-homing to palatine tonsils of the musk shrew, a new experimental animal originally developed in japan. the tonsils of the animals have typically high endothelial venules (hev) in the parafollicular region. the in vivo migration test showed that blood-circulating lymphocytes were able to home to the tonsils through the hev. the in vitro lymphocyte-hev binding assay clearly indicated the binding preference of the lymphocytes to be the tonsillar hev. first, binding of b ce ... | 1996 | 9082798 |
| coexistence of tyrosine hydroxylase and serotonin in the raphe nucleus of the laboratory shrew (suncus murinus) during postnatal life. | immunoreactivity (ir) of tyrosine hydoroxylase (th), which is the rate-limiting enzyme of catecholamine (ca) synthesis, was observed in the serotonergic neurons of the raphe nucleus (rn) of the newborn laboratory shrew from postnatal day (p) 0 to p14. using an immunohistochemical method involving highly specific antibodies produced in our laboratory, we found that these rn neurons were th-, gtp cyclohydrolase i-, aromatic l-amino acid decarboxylase-immunoreactive, but dopa- and dopamine-immunone ... | 1997 | 9088574 |
| comparative anatomical studies on the thyroid and thymic arteries. v. house musk shrew (suncus murinus). | the thyroid and thymic arteries were investigated in 36 male and 36 female house musk shrews. the superior thyroid artery was constant. the artery arose, in the most instances, from the external carotid arteries. the artery, in about one fourth instances, sent both the superior and inferior branches supplying the gland and the former branch terminated in the superior and inferior laryngeal arteries. the latter branch was independent in the remaining instances. the superior laryngeal artery was i ... | 1997 | 9128061 |
| involvement of a peripheral mechanism in the emesis induced by cardiac glycosides in suncus murinus. | the ability of three cardiac glycosides, ouabain, digitonin and digitoxin, to induce emesis and their mechanism(s) of action were investigated in suncus murinus. the intraperitoneal injection of ouabain but not digitonin nor digitoxin caused vomiting in a dose-dependent manner. however, the administration of ouabain into the cerebroventricle did not cause emesis. ouabain-induced emesis was partly prevented by surgical abdominal vagotomy. pretreatment with tropisetron, a selective 5-ht3 (5-hydrox ... | 1997 | 9178926 |
| low activity of aldehyde dehydrogenase (aldh) in liver of suncus murinus: possible explanation for high sensitivity to alcohol. | suncus murinus (suncus) is an animal species highly sensitive to ethanol (lin, s.-c., saito, h., yohro, t. and shiga, j.,j. toxicol. env. health, 18: 575-587, 1986). to elucidate the mechanism involved in sensitivity to alcohol, we investigated that properties of alcohol dehydrogenase (adh) and aldehyde dehydrogenase (aldh) in the suncus in comparison with the rat. the activities of aldh in microsomes and mitochondria of suncus livers were lower than those in rat livers, although the activity of ... | 1997 | 9198008 |
| significance of the localization of large granules in the thyrogonadotrophs of the musk shrew (suncus murinus). | in order to examine the significance of small round and large granules in the thyrogonadotrophs of the musk shrew, we investigated the differences of numbers, distribution patterns and/or immunoreactivities of the large granules in the thyrogonadotrophs among the newborn, infant and adult musk shrews. as a result, we observed that the thyrogonadotrophs exist in newborn musk shrew, but the large granules were few in number and immunoreactivity on the granules was weak. the ratio of the number of ... | 1997 | 9225488 |
| ovulation induction and gamete transport in the female tract of the musk shrew, suncus murinus. | the musk shrew suncus murinus was studied with regard to induction of ovulation, the genesis and role of the vaginal copulation plug, and the behaviour of gametes and embryos within the fallopian tube. ovulation occurred about 15 h after ejaculation, which required a mean of 5.2 (range 2-10) intromittent thrusts. since ovulation occurred also after five thrusts without ejaculation, and after ejaculation without plug formation or sperm deposition, the primary stimulus for this seemed to be the th ... | 1997 | 9227365 |
| the unusual state of the cumulus oophorus and of sperm behaviour within it, in the musk shrew, suncus murinus. | in the musk shrew, suncus murinus, the behaviour of the cumulus-egg complex and its interaction with spermatozoa were unusual in several respects. the cumulus oophorus was ovulated about 15.5 h after mating or treatment with hcg as a hyaluronidase-insensitive matrix-free ball of cells which remained for relatively long periods of about 14 h around fertilized, and for about 24 h around unfertilized eggs. as a probable function of the small number of up to about 10 or 20 spermatozoa that generally ... | 1997 | 9227366 |
| blood supply to the retina in the laboratory shrew (suncus murinus). | the blood supply to both retinae was studied light microscopically and by scanning electron microscopy in 48 adult laboratory shrews (suncus murinus) of both sexes. thirty-eight of the animals were injected into the left ventricle with neoprene latex (du pont. 601a) or with mercox (dai nippon ink ltd., cl-2r) to elucidate the blood supply to the retina from the ophthalmic artery. the remaining animals were kept for histological study of the retina. the central retinal artery, originating from th ... | 1997 | 9229077 |
| superovulation induction in the house musk shrew (suncus murinus). | the number of ovulated oocytes in the adult house musk shrews was examined by natural mating. the positive rate of ovulation was 83.3%, and the mean number of ovulated oocytes was 4.4 +/- 1.9 (mean +/- sd). the induction of superovulation was examined by administering either pregnant mare's serum gonadotropin (pmsg) or human chorionic gonadotropin (hcg), exogenous gonadotropin, to house musk shrews. as a result, the number of ovulated oocytes were within the number of oocytes ovulated spontaneou ... | 1997 | 9250478 |
| antiemetic effects of morphine on motion- and drug-induced emesis in suncus murinus. | emetic and antiemetic effects of morphine were investigated in suncus murinus. subcutaneous (up to 30 mg/kg) or intracerebroventricular administration (50 micrograms) of morphine failed to cause emesis. however, pretreatment with morphine (s.c.) prevented the emesis induced by nicotine (10 mg/kg, i.p.), copper sulfate (40 mg/kg, p.o.), cisplatin (20 mg/kg, i.p.) and motion stimulus. these results suggest that morphine has only antiemetic potency and may block a common mechanism for the emetic re ... | 1997 | 9255411 |
| male/female differences in drug-induced emesis and motion sickness in suncus murinus. | in order to elucidate possible male/female differences in emesis, the effects of various emetogenic drugs (cisplatin, copper sulfate, veratrine, nicotine, serotonin) and motion stimulus were compared between male and female suncus murinus. cisplatin (ip), nicotine (sc), veratrine (sc) and copper sulfate (po) induced dose-dependent emesis in either sex, and there was no apparent difference in estimated ed50 values. however, male animals tended to be more susceptible to serotonin-induced emesis. t ... | 1997 | 9258999 |
| the period of ovulation and presence of the first polar body of ova ovulated in the house musk shrew (suncus murinus). | the period of ovulation in mature house musk shrews was examined in a natural mating group and a superovulation group treated with gonadotropin. in the natural mating group, ovulation started 14 hr after mating in 3 of the 7 house musk shrews (42.8%), and occurred in all 5 house musk shrews by 15 hr after mating. in the superovulation group, ovulation started 13 hr after the administration of hcg in 3 of the 5 house musk shrews, and was observed in all 5 shrews by 16 hr after the administration. ... | 1997 | 9353637 |
| pepsinogens and pepsins from house musk shrew, suncus murinus: purification, characterization, determination of the amino-acid sequences of the activation segments, and analysis of proteolytic specificities. | three pepsinogens, namely, pepsinogens a, c-1, and c-2, were purified from gastric mucosa of adult house musk shrew (suncus murinus) by conventional chromatographic and gel filtration procedures. the molecular masses were 40, 39, and 41 kda for pepsinogens a, c-1, and c-2, respectively. pepsinogen c-2 contains an asn-linked carbohydrate chain(s) of about 2 kda. each pepsinogen was converted to pepsin through an intermediate form under acidic conditions. by nh2-terminal sequence analysis of these ... | 1997 | 9354369 |
| behavioral regulation of gonadotropin-releasing hormone production. | in vertebrates reproductive readiness requires coordination between the sexes. behavioral interactions with potential mates can initiate the neuroendocrine events that are required for successful copulation, ovulation, and fertilization. regardless of the efferent pathway used, their targets are the neurons that produce and secrete gonadotropin-releasing hormone (gnrh). several excellent animal models are currently under use to study the relationship between behavior and gnrh. in the musk shrew ... | 1997 | 9370211 |
| [chromosome coupling in robertsonian heterozygotes in common (sorex araneus) and musk (suncus murinus) shrews]. | 1997 | 9376804 | |
| [geography of chromosomes of natural populations of the shrews sorex araneus and suncus murinus]. | the geographic distribution of chromosome races of two shrew species (sorex araneus and suncus murinus) was analyzed on the basis of published data and personal results. it was shown that expansion of both species was accompanied by fixation of different chromosome rearrangements (mainly robertsonian translocations) in isolates. chromosome polymorphism studied from the viewpoint of ecology and geography of these species allows reconstruction of their evolutionary history and understanding of the ... | 1997 | 9378305 |
| selective inhibitors of cyclic amp-specific phosphodiesterase: heterocycle-condensed purines. | to reverse the adverse reactions of alkylxanthines and to develop novel inhibitors of cyclic amp-specific phosphodiesterase (pde iv), a series of heterocycle-condensed purines were designed and synthesized. some of these new compounds had similar or more potent and selective inhibitory activity against pde iv than known pde iv inhibitors. the tracheal-relaxant activity of these compounds was closely correlated with their pde iv-inhibitory activity. moreover, these purine analogues did not have a ... | 1997 | 9379444 |
| localization of the genes for major ribosomal rna on chromosomes of the house musk shrew, suncus murinus, at meiotic and mitotic cells by fluorescence in situ hybridization and silver staining. | the genes for major ribosomal rna were localized on chromosomes 5pter-p15, 9q64-qter, and 13q38-qter of the house musk shrew, suncus murinus (insectivora, soricidae) by silver staining of mitotic metaphase and meiotic pachytene spreads and fluorescence in situ hybridization using the human 28s-rna genes as a probe to mitotic metaphase spreads. the data presented indicate a correlation between sites of in situ hybridization and silver staining. the finding of nuclear materials in mitosis was in a ... | 1997 | 9418261 |
| distribution pattern of hnf-3beta proteins in developing embryos of two mammalian species, the house shrew and the mouse. | the pattern of expression of hnf-3beta in organizing centers and axial structures during early vertebrate development suggests an important role for this protein in the establishment of the vertebrate body plan. to establish whether the pattern of expression during embryogenesis is species specific, a comparative immunohistochemical study of two mammalian species, the house shrew, insectivore, and the mouse was carried out; it is difficult to obtain accurate morphological differences from the st ... | 1997 | 9493826 |
| segregation analysis of animal pedigree data from inter-population crosses. | the general method of segregation analysis of pedigree data has been developed and widely used in human genetics. we modified this method to examine pedigree data coming from inter-population crosses. these kinds of pedigrees are common in laboratory and farm animal breeding. this paper describes a rationale for the method and illustrates its application to the study of inheritance of litter size and of male sterility in hybrid stock of the house musk shrew (suncus murinus) derived from crosses ... | 1997 | 9511225 |
| a new spontaneous animal model of niddm without obesity in the musk shrew. | the eds (early-onset diabetes in suncus) colony has been developed as a new closed breeding colony of the musk shrew (suncus murinus, insectivora) exhibiting a high incidence of spontaneous diabetes mellitus. we investigated the characteristic features of diabetic shrews in this colony. all diabetic shrews are characterized by glycosuria (tes-tape value > or = 3+), hyperglycemia (23.3 +/- 0.8 mmol/l) and polyuria, and they were affected by the age of 3 months. cumulative incidence (64.1% in male ... | 1998 | 9515557 |
| oxidation of fatty acids by kidney microsomes of musk shrew (suncus murinus). | substrate specificity and other properties of a fatty acid monooxygenase system in kidney microsomes of the japanese house musk shrew (suncus murinus) were examined. the suncus kidney microsomes catalyzed the hydroxylation of various saturated and unsaturated fatty acids to the omega- and (omega-1)-hydroxy derivatives. laurate was most effectively hydroxylated among saturated and unsaturated fatty acids. the specific activity (53.79 +/- 5.59 [mean +/- sd, n = 6] nmol/nmol cytochrome p450/min) of ... | 1998 | 9530812 |
| serotonergic neurons are present and innervate blood vessels in the olfactory bulb of the laboratory shrew, suncus murinus. | the distribution and characteristics of serotonin-immunoreactivity in the olfactory bulb of the laboratory shrew (suncus murinus, insectivore) was studied immunohistochemically. serotonergic neurons were found only in the subependymal layer of the main olfactory bulb. these neurons were 8-12 microm in size and bipolar in shape. these serotonergic neurons had smooth nerve fibers which innervate blood vessels located mainly in the subependymal layer of the main olfactory bulb. on the other hand, o ... | 1998 | 9535111 |
| chromosome pairing in inter-racial hybrids of the house musk shrew (suncus murinus, insectivora, soricidae). | two chromosome races of the house shrew suncus murinus that differ from each other for five robertsonian translocations (8.17, 9.13, 10.12, 11.16, and 14.15), heterochromatic insertions in chromosomes 7 and x, and multiple rearrangements in the y chromosome were crossed and then intercrossed in captivity to produce a hybrid stock. electron-microscopic analysis of synaptonemal complexes in fertile and sterile hybrid males was carried out. meiosis in sterile males did not progress beyond pachytene ... | 1998 | 9549061 |
| entomological and rodent surveillance in plague-suspected areas during september 1994 and thereafter. | studies carried out in the states of maharashtra, gujarat, uttar pradesh and union territory of delhi after the bubonic plague outbreak during 1994 revealed the presence of seven species of rodents, viz. rattus rattus, r. norvegicus, mus. musculus, tatera indica, suncus murinus, bandicoota bengalensis and b. indica. the flea species encountered were xenopsylla cheopis and x. astia. the x. cheopis and x. astia index recorded in different areas of beed district of maharashtra; surat, vadodra and b ... | 1997 | 9556751 |
| open eyelids at birth, a new mutation in the musk shrew, suncus murinus. | the mutation designated "open eyelids at birth" arose spontaneously in the ban strain of the musk shrew (suncus murinus). this is the first report on this kind of mutation in the shrew. mating experiments suggested that the mutant character is controlled by an autosomal recessive gene with about 43% penetrance. the symbol oeb(open eyelids at birth) was proposed for the mutant gene. affected shrews were fully viable and fertile. phenotypically, the affected shrews were characterized by one or bot ... | 1998 | 9606420 |
| phylogenetic positions of insectivora in eutheria inferred from mitochondrial cytochrome c oxidase subunit ii gene. | for the elucidation of the phylogenetic position of insectivora in eutheria, we have sequenced the cytochrome c oxidase subunit ii (coii) gene of mitochondria for three insectivoran species [musk screw (suncus murinus), shrew mole (urotrichus talpoides), japanese mole (mogera wogura)] and analyzed these amino acid sequences with neighbor-joining (nj) method and maximum likelihood (ml) method. nj analysis shows polyphyly of insectivora and chiroptera. assuming that each of primates, ferungulata, ... | 1998 | 9615624 |
| branches of the vagus nerve destined for the heart and the adjoining great vessels in the house shrew, suncus murinus, with reference to the terminology of the vagal cardiac branches. | in order to help to organize the understanding of the bewildering complexities of the innervation of the mammalian heart by the vagus nerve and to clear up of confusions as regards the vagus cardiac branches, we scrutinized these branches in the adult house shrew, suncus murinus, under a stereomicroscope. a number of branches were given off from the vagus nerve not only to the heart, but also to the adjoining great vessels, both outflowing and inflowing. when compared from the developmental view ... | 1998 | 9617080 |
| isolation and characterization of helicobacter species from the stomach of the house musk shrew (suncus murinus) with chronic gastritis. | a gram-negative, motile bacterium with bipolar sheathed flagella (one at each end) was isolated from the stomach of house musk shrews (suncus murinus) with chronic gastritis. the isolates grew at 37 degrees c under microaerophilic conditions, but not under aerobic conditions; rapidly hydrolyzed urea; were catalase, oxidase, alkaline phosphatase, and arginine aminopeptidase positive; reduced nitrate to nitrite; and were resistant to cephalothin and nalidixic acid, but sensitive to tetracycline, e ... | 1998 | 9625789 |
| brainstem topology of the vagal motoneurons projecting to the esophagus and stomach in the house musk shrew, suncus murinus. | the central origin of vagal efferents innervating the esophagus and stomach in the house musk shrew, suncus murinus, was studied using the retrograde tracing technique. the animals were perfused with fixative 48-72 h after hrp injection and sections were processed by hrp histochemistry. hrp application into the gastroesophagus resulted in bilateral labelling of neurons in the dorsal motor nucleus of the vagus nerve (dmx) and ambiguous nucleus (an). labelled neurons in the dmx were observed from ... | 1998 | 9626945 |
| molecular cloning of sucrase-isomaltase cdna in the house musk shrew suncus murinus and identification of a mutation responsible for isolated sucrase deficiency. | isolated sucrase deficiency has been demonstrated in a line of house musk shrew, suncus murinus (laboratory name: suncus). this animal belongs to the order insectivore and is phylogenetically different from ordinarily used laboratory animals. they are believed to have evolved with mainly animal food without sucrose. to study the molecular basis of the sucrase deficiency in suncus, we cloned 6. 0-kilobase (kb) sucrase-isomaltase (si, ec 3.2.1.48-10) cdna from suncus intestinal cdna library. the c ... | 1998 | 9632713 |
| neuromuscular transmission and innervation in the urinary bladder of the insectivore suncus murinus. | in isolated preparations of the urinary bladder detrusor of the house musk shrew suncus murinus (order: insectivora; family: soricidae), electrical field stimulation (0.5-32 pulses/s) evoked neurogenic contractile responses that were markedly attenuated by atropine (1 microm). the non-cholinergic component was reduced but not abolished by the p2-purinoceptor antagonist, suramin (300 microm). thus, neuromuscular transmission in the suncus urinary bladder is effected by cholinergic and purinergic ... | 1998 | 9672121 |
| inheritance of litter size at birth in the house musk shrew (suncus murinus, insectivora, soricidae). | in this research we estimated the contribution of a major-gene effect to the control of litter size in hybrids between two local populations of the house musk shrew (suncus murinus). segregation analysis was performed on the basis of a mixed polygene and major-gene model. the model presumes that two parental populations may differ from each other in gene frequencies and in the values of polygenic effects but not in the major-gene contribution of the trait. moreover, the peculiarity of the trait- ... | 1998 | 9674383 |
| co-localization of estrogen receptor and aromatase enzyme immunoreactivities in adult musk shrew brain. | estrogens are produced by the aromatization of androgens. these steroids exert their actions after binding to their receptors. past studies have shown that estrogen receptors (er) and aromatase enzyme (arom) reside in many of the same brain regions. few studies, however, have examined the neural co-localization of these important components involved in estrogen-activated behaviors. in the present study we examined the co-localization of er and arom immunoreactive (ir) neurons in musk shrew (sunc ... | 1998 | 9698499 |
| an xxy sex chromosome constitution in a house musk shrew (suncus murinus l.) with testicular hypoplasia. | an adult male house muck shrew with an xxy sex chromosome constitution was found in a laboratory-bred colony. maternal origin of the additional x chromosome was demonstrated. the external appearance of the animal was normal, but the testes were small and displayed a high density of interstitial cells. the seminiferous tubules were narrow and contained only sertoli cells. | 1998 | 9713381 |
| ascending projections from the area postrema and the nucleus of the solitary tract of suncus murinus: anterograde tracing study using phaseolus vulgaris leucoagglutinin. | suncus murinus (suncus) is a new experimental animal model for research on the mechanisms underlying emesis. in the present study, we examined the ascending projections from the area postrema (ap) and the nucleus of the solitary tract (nts) in suncus based on anterograde transport of phaseolus vulgaris leucoagglutinin. the ap projected heavily to the dorsal vagal complex, especially in the commissural and medial subnuclei of the nts, and the dorsal motor nucleus of the vagus. some ascending fibe ... | 1998 | 9715082 |
| toxin-induced iddm (insulin dependent diabetes mellitus) in the musk shrew. | we administered streptozotocin (stz) and alloxan (al) to the musk shrew (suncus murinus, insectivora) to determine the effective diabetogenic dose of the two toxins for this species. a single intraperitoneal (i.p.) injection of 75 mg/kgbw or the consecutive 5-day s injection of 25 mg/kgbw of stz to non-fasted shrews, effectively (100%) induced hyperglycemia (> or = 300 mg/dl) with hypoinsulinaemia (< 30% of control level) in male shrews at 10 days after administration. morphological studies show ... | 1998 | 9718069 |
| the endotheliochorial interhemal membrane of the indian musk shrew, suncus murinus: an ultrastructural study. | even though the chorioallantoic placenta of suncus has been previously investigated with light and electron microscopy, controversies related to its structure still remain. to resolve these, suncus murinus placentae from several (early and late limb bud, advanced pregnancy, and full term) were examined by electron microscopy. the interhemal membrane of suncus comprises a maternal endothelium with basal lamina, syncytial trophoblast with its basal lamina, fetal mesenchyme, and fetal capillary end ... | 2003 | 9719774 |
| brainstem origin of the efferent components of the cervical vagus nerve in the house musk shrew, suncus murinus. | the brainstem origin of the efferent neurons of the vagus nerve in the house musk shrew, an animal species which has been recently used in researches on emesis, was studied using the retrograde tracing method. the vagus nerve was exposed and cut at the mid-cervical level below the nodose ganglion. horseradish peroxidase was applied to the proximal end of the cut nerve. the brainstem was sectioned and processed histochemically with the tetramethylbenzidine method. the horseradish peroxidase injec ... | 1998 | 9722195 |
| appearance and distribution of two ca2+-binding proteins during development of the cochlea in the musk shrew. | in the developing cochlea of the musk shrew, suncus murinus, the localization of two ca2+-binding protein, calbindin and calmodulin, which are thought to play different roles in the nervous system, was examined during gestational and postpartum periods. calbindin is thought to play a ca2+ buffering role, while calmodulin activates other proteins. cochleae from the musk shrews sacrificed from gestational day (gd) 15 to postnatal day (pp) 9 and as adults, were immunohistochemically analyzed. the l ... | 1998 | 9733905 |
| chromosomal segregation and fertility in robertsonian chromosomal heterozygotes of the house musk shrew (suncus murinus, insectivora, soricidae). | crucial to our understanding of chromosomal variation and evolution in mammals are detailed studies of chromosomal heterozygotes, with analyses of chromosomal segregation and chromosome-derived infertility. we studied segregation and fertility in hybrids between karyotypic races of the house musk shrew suncus murinus. these individuals were heterozygous for up to five robertsonian fusions (rbs) and an insertion of heterochromatin in an autosome. all variant chromosomes showed mendelian segregati ... | 1998 | 9800372 |
| induction of fos-like immunoreactivity in musk shrews after mating. | in many mammalian species the neuroendocrine regulation of male and female reproductive behavior is sexually dimorphic. by contrast, many features of female sexual behavior in the musk shrew (suncus murinus) more closely resemble those of males than of females of other species. female musk shrews require testosterone (t), which is neurally aromatized to estrogen, to induce sexual behavior. aromatization occurs in the medial preoptic area (mpoa), and this region is critical for the expression of ... | 1998 | 9804874 |
| parvalbumin immunoreactive neurons in the main olfactory bulb of the house musk shrew, suncus murinus. | the distribution, morphological features, and postnatal development of parvalbumin (pv) immunoreactive neurons in the main olfactory bulb (mob) of the house musk shrew, suncus murinus, were studied to report for the first time on pv positive bulbar interneurons in the order insectivora. in adult animals, pv neurons are distributed in the glomerular layer (gl), the external plexiform layer (epl), the internal plexiform layer (ipl) and the granule cell layer (gcl) of the mob. these neurons were id ... | 1998 | 9807013 |
| [update on plague in madagascar]. | after a thirty year period of successful control, bubonic plague showed the first signs of return in madagascar where a fatal outbreak occurred in antananarivo in 1978. a second outbreak was observed in mahajanga in 1991 after more than a half century. in 1997, 459 confirmed or presumptive cases were reported, as compared to 150 to 250 cases during the last years. however the actual extent of this recrudescence must be placed in the perspective of a more efficient control program that has led to ... | 1998 | 9812306 |
| sex differences in mammalian and chicken-ii gonadotropin-releasing hormone immunoreactivity in musk shrew brain. | many vertebrates have more than one molecular form of gonadotropin-releasing hormone (gnrh) present in brain. in all cases documented to date, gnrh neurons located in the forebrain are critical players in the brain-pituitary-gonadal feedback axis although the details of how steroids regulate gnrh remain elusive. the function of the second form, usually produced in cells in the midbrain, is not known. it has been hypothesized that this gnrh acts as a neurotransmitter. in the musk shrew (suncus mu ... | 1998 | 9843640 |
| neonatal androgen affects copulatory behavior in the female musk shrew. | the role of neonatal testosterone in the development of copulatory behavior was examined in an insectivore, the musk shrew (suncus murinus). female musk shrews were treated with testosterone propionate (tp) for the first 5 days of life and then tested in adulthood for either female or male-like copulatory behavior. early tp had a masculinizing effect; neonatally treated animals mounted a stimulus female more frequently, and with shorter latencies, in response to adult testosterone treatment than ... | 1998 | 9878272 |
| inhibition of anaesthetic-induced emesis by a nk1 or 5-ht3 receptor antagonist in the house musk shrew, suncus murinus. | the effects of a nk1 antagonist, gr205171, and a 5-ht3 antagonist, ondansetron, in a novel model of post-anaesthesia-induced emesis in suncus murinus is described. gr205171 (1 and 3 mg k(-1) s.c) and ondansetron (3 mg kg(-1) s.c.) each significantly inhibited emesis. this model may be useful for studying drugs to treat post-operative nausea and vomiting in man. | 1998 | 9886687 |
| inheritance of male hybrid sterility in the house musk shrew (suncus murinus, insectivora, soricidae). | two geographic races of the house musk shrew (suncus murinus) were crossed and intercrossed in the laboratory. many cases of male sterility were detected among the hybrids. segregation analysis of the pedigree data showed that the inheritance of male sterility in interracial hybrids of s. murinus can be described within the framework of monogene polyallele model with sterility of a single allele combination. this model is similar if not identical to that proposed by dobzhansky and muller. | 1998 | 9924792 |
| inhibition of emesis by tachykinin nk1 receptor antagonists in suncus murinus (house musk shrew). | the anti-emetic potential of cp-122,721 ((+)-2s,3s)-3-(2-methoxy-5-trifluoromethoxybenzyl)amino-2-phenylpi peridine), cp-99,994 ((+)-(2s,3s)-3-(2-methoxybenzylamino)-2-phenylpiperidine), cp-100,263 ((-)-(2r,3r)-3-(2-methoxybenzylamino)-2-phenylpiperidine), rp 67580 ((3r, 7ar)-7,7-diphenyl-2-[1-imino-2-(2-methoxyphenyl)ethyl] po-hydroisoindol-4-one), fk 888 (n2-[(4r)-4-hydroxy-1-(1-methyl-1h-in-dole-3-yl)carbonyl-l-propyl] -n-methyl-n-phenylmethyl-1-3-(2-naphthyl)-alaninamide) and gr 82334 ([d-pr ... | 1999 | 10082206 |
| temporal aspects of female musk shrew (suncus murinus) sexual behavior. | the effects of testing condition on sexual behavior were examined in female musk shrews (suncus murinus). females were tested in 2 conditions, a pair test and a paced test. the pair test was similar to traditional sex test conditions in which the female and male are placed into the same chamber together until mating occurs. the paced condition allowed the female to leave the male's chamber and revisit him at will, thus "pacing" the interaction. females displayed receptivity continuously for 14 d ... | 1999 | 10098271 |