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electron microscope observations on the behavior of the bacterial cytoplasmic membrane during cellular division.bacterial cells were fixed in oso(4), washed, dehydrated, and embedded in a methacrylate mixture. ultrathin sections were cut on a porter-blum ultramicrotome and were examined in an rca electron microscope, type emu-2d. the sections revealed that the cytoplasmic membrane undergoes a centripetal growth to form a membrane septum. this septum is formed as a double structure. constriction of the daughter cells and deposition of cell wall material lead to the separation of the daughter cells. the bac ...195913809225
surgeon apprentice and naturalist: being incidents from the journal of william l. crowther during the voyage of the barque "emu" from van diemen's land to london dock, february 24 to june 23, 1839. 196013813060
arteriosclerosis in the ostrich, rhea, and emu: naturally occurring lesions of the aortas and coronary arteries. 196514254909
arteriosclerosis in the ostrich, rhea, and emu. 196514318834
aberrant expression of the lhx4 lim-homeobox gene caused by t(1;14)(q25;q32) in chronic myelogenous leukemia in biphenotypic blast crisis.chromosomal aberrations observed in addition to the philadelphia chromosome in chronic myelogenous leukemia (cml) are likely to be involved in disease progression to the blast crisis. we describe here a t(1;14)(q25;q32) as an additional chromosomal aberration in a patient with cml in biphenotypic blast crisis. by use of long-distance inverse polymerase chain reaction (pcr), we cloned the chromosomal breakpoint and revealed that the immunoglobulin heavy chain gene is fused near its emu enhancer r ...200314506703
development of t-cell lymphomas in emu-iex-1 mice.inhibition of apoptosis or abnormal cell survival can result in tumorigenesis by facilitating the insurgence of various mutations. immediate-early response gene x-1 (iex-1), protects t cells from apoptosis induced by the ligation of fas or the t-cell receptor (tcr)/cd3 complex in emu-iex-1 mice that direct the gene expression in both t and b cell lineages under the control of the emu enhancer. consistent with a biased effect of iex-1 towards t cells, emu-iex-1 mice selectively developed t-cell l ...200314534530
hydrothermal synthesis in the system ni(oh)(2)-niso(4): nuclear and magnetic structures and magnetic properties of ni(3)(oh)(2)(so(4))(2)(h(2)o)(2).we present the synthesis, characterization by dt-tga and ir, single crystal x-ray nuclear structure at 300 k, nuclear and magnetic structure from neutron powder diffraction on a deuterated sample at 1.4 k, and magnetic properties as a function of temperature and magnetic field of ni(3)(oh)(2)(so(4))(2)(h(2)o)(2). the structure is formed of chains, parallel to the c-axis, of edge-sharing ni(1)o(6) octahedra, connected by the corners of ni(2)o(6) octahedra to form corrugated sheets along the bc-pl ...200314552637
the beta-globin hs4 insulator confers copy-number dependent expression of igh regulatory elements in stable b cell transfectants.locus control regions (lcr) were first defined by their theoretical ability to enhance the expression of linked genes in a tissue-specific, position-independent and copy-number dependent manner. in fact, few of the so-called lcr identified completely fulfil this definition. for example, the regulatory elements located in 5' (emu) and 3' (hs3a; hs1,2; hs3b; hs4) of the igh locus display some properties of a lcr but lack a copy-number dependence and sometimes display position effects in transgenes ...200314556968
combination of 3' and 5' igh regulatory elements mimics the b-specific endogenous expression pattern of igh genes from pro-b cells to mature b cells in a transgenic mouse model.to ensure the b cell differentiation stage specificity of the intronic emu element and of the locus control region (lcr) that lies downstream of the igh chain locus, we generated transgenic mice harboring a v(h) promoter-gfp reporter gene linked to the 3'lcr region and the emu element. by flow cytometry, gfp(+) lymphocytes were observed amongst pro-b cells (b220(+)cd43(+)cd117(+)) and at all stages of differentiation up to mature b cells (b220(+)igm(+)igd(+)). expression was strictly confined to ...200314572901
pathogenicity of a ratite-origin influenza a h5 virus in ostriches (struthio camelus).ostriches were inoculated with a highly pathogenic avian influenza (hpai) virus of ratite origin, a/emu/texas/39924/93 (h5n2) done clb. the aim of this study was to evaluate the pathogenicity of this isolate for ostriches and to assess the ability of routine virologic and serologic tests to detect infection. avian influenza virus (aiv) was isolated from tracheal swabs from 2 to 12 days postinfection and from cloacal swabs from 3 to 10 days postinfection. aiv was also isolated from a wide range o ...200314575143
distribution of spermatozoa in the outer perivitelline layer from above the germinal disc of emu and ostrich eggs.in the present study, we determined the distribution of spermatozoa in the perivitelline layer above the germinal disc (gd) of emu and ostrich eggs that had been laid at random intervals after mating. eggs were opened, the perivitelline layer overlying the gd region was collected and sperm were visualized with 4',6'-diamidino-2-phenylindole under a fluorescence microscope. to map the distribution of sperm, the gd was divided into six areas (a-f), with a being the centre of the gd and f the area ...200314588183
search for lepton flavor violating decays of a heavy neutral particle in p(-)p collisions at sqrt[s]=1.8 tev.we report on a search for a high mass, narrow width particle that decays directly to emu, etau, or microtau. we use approximately 110 pb(-1) of data collected with the collider detector at fermilab from 1992 to 1995. no evidence of lepton flavor violating decays is found. limits are set on the production and decay of sneutrinos with r-parity violating interactions.200314611332
comparison of thermal insulation performance of fibrous materials for the advanced space suit.the current multi-layer insulation used in the extravehicular mobility unit (emu) will not be effective in the atmosphere of mars due to the presence of interstitial gases. alternative thermal insulation means have been subjected to preliminary evaluation by nasa to attempt to identify a material that will meet the target conductivity of 0.005 w/m-k. this study analyzes numerically the thermal conductivity performance for three of these candidate insulating fiber materials in terms of various de ...200314618923
pathotyping of a newcastle disease virus isolated from emus (dromaius novaehollandiae). 200314620583
targeted overexpression of bcl-xl in b-lymphoid cells results in lymphoproliferative disease and plasma cell malignancies.multiple myeloma is an incurable malignancy, and there is currently no mouse model that fully recapitulates the development and progression of the disease. we now describe a transgenic mouse that expresses a bcl-xl transgene under the control of the 3'kappa immunoglobulin light chain enhancer, which is most active in murine b cells in late developmental stages. these mice developed nonmalignant plasma cell foci in the bone marrow and soft tissues and hyaline tubular casts in the kidneys. median ...200414656874
ferromagnetism in fcc twinned 2.4 nm size pd nanoparticles.the onset of ferromagnetism has been experimentally observed in small pd particles of average diameter 2.4 nm. high-resolution studies reveal that a high percentage of the fcc particle exhibits single and multiple twinning boundaries. the spontaneous magnetization close to 0.02 emu/g seems to indicate that only a small fraction of atoms holds a permanent magnetic moment and contributes to ferromagnetism. the possible origin of ferromagnetism is briefly discussed according to different models rec ...200314683211
high incidence of thymic epithelial tumors in e2f2 transgenic mice.in virtually all human tumors, genetic and epigenetic alterations have been found which affect the ink4/-cyclin d/rb pathway, which regulates cell cycle entry and exit in normal cells. e2f transcription factors are important downstream components of this pathway, which act by controlling the expression of genes involved in dna replication and cell cycle progression. to determine whether e2f2 deregulation promotes proliferation and tumorigenesis in vivo, we generated e2f2 transgenic mice, in whic ...200414684733
differential emu enhancer activity and expression of bob.1/obf.1, oct2, pu.1, and immunoglobulin in reactive b-cell populations, b-cell non-hodgkin lymphomas, and hodgkin lymphomas.it has previously been demonstrated that in cultured and in situ tumour cells of classical hodgkin lymphoma (chl), the immunoglobulin (ig) promoter is inactive and its transcription factors oct2 and/or bob.1/obf.1 are down-regulated. in this study, the analysis of these transcription factors has been extended to a broad spectrum of b-cell malignancies and the findings have been related to the situation in normal b-cells of various differentiation stages and to the expression of ig. furthermore, ...200414694522
apaf-1 and caspase-9 do not act as tumor suppressors in myc-induced lymphomagenesis or mouse embryo fibroblast transformation.based on experiments with cultured fibroblasts, the apoptosis regulators caspase-9 and apaf-1 are hypothesized to function as tumor suppressors. to investigate their in vivo role in lymphomagenesis, an igh enhancer-driven c-myc transgene was crossed onto apaf-1(-/-) and caspase-9(-/-) mice. due to perinatal lethality, emu-myc transgenic apaf-1(-/-) or caspase-9(-/-) fetal liver cells were used to reconstitute lethally irradiated recipient mice. surprisingly, no differences were seen in rate, inc ...200414709542
maternal effects of egg size on emu dromaius novaehollandiae egg composition and hatchling phenotype.parental investment in eggs and, consequently, in offspring can profoundly influence the phenotype, survival and ultimately evolutionary fitness of an organism. avian eggs are excellent model systems to examine maternal allocation of energy translated through egg size variation. we used the natural range in emu dromaius novaehollandiae egg size, from 400 g to >700 g, to examine the influence of maternal investment in eggs on the morphology and physiology of hatchlings. female emus provisioned la ...200414718503
identification of angiotensin i in several vertebrate species: its structural and functional evolution.in order to delineate further the molecular evolution of the renin-angiotensin system in vertebrates, angiotensin i (ang i) has been isolated after incubation of plasma and kidney extracts of emu (dromiceus novaehollandiae), axolotl (ambystoma mexicanum), and sea lamprey (petromyzon marinus). the identified sequences were [asp1, val5, asn9] ang i in emu, [asp1, val5, his9] ang i in axolotl, and [asn1, val5, thr9] ang i in sea lamprey. these results confirmed the previous findings that tetrapods ...200414723880
molecular paramagnetic semiconductor: crystal structures and magnetic and conducting properties of the ni(dmit)(2) salts of 6-oxoverdazyl radical cations (dmit = 1,3-dithiol-2-thione-4,5-dithiolate).four kinds of 1:1 and 1:3 salts of 3-[4-(trimethylammonio)phenyl]-1,5-diphenyl-6-oxoverdazyl radical cation ([1](+)) and its mono- and dimethyl derivatives ([2](+) and [3](+)) with ni(dmit)(2) anions (dmit = 1,3-dithiol-2-thione-4,5-dithiolate) ([1](+)[ni(dmit)(2)](-) (4), [2](+)[ni(dmit)(2)](-) (5), [3](+)[ni(dmit)(2)](-) (6), and [1](+)[ni(dmit)(2)](3)(-) (7)) have been prepared, and the magnetic susceptibilities (chi(m)) have been measured between 1.8 and 300 k. the chi(m) values of salts 5 a ...200414731018
syntheses, structures, and physical properties of nickel bis(dithiolene) complexes containing tetrathiafulvalene (ttf) units.to contribute to the development of single-component molecular metals, several nickel complexes with cyclohexeno-condensed or ethylenedioxy-substituted ttf (tetrathiafulvalene) dithiolate ligands, (r(4)n)(n)[ni(chdt)(2)] [r = me, n = 2 (1); r = (n)bu, n = 1 (2); n = 0 (3)] and (r(4)n)(n)[ni(eodt)(2)] [r = me, n = 2 (4); r = (n)bu, n = 1 (5); n = 0 (6)], were prepared. x-ray structures were determined on the monoanionic species 2 and 5. the tetra-n-butylammonium complex of the monoanionic [ni(chd ...200414753836
osteocyte-based image analysis for quantitation of histologically apparent femoral head osteonecrosis: application to an emu model.femoral head osteonecrosis is often characterized histologically by the presence of empty lacunae in the affected bony regions. the shape, size and location of a necrotic lesion influences prognosis, and can, in principle, be quantified by mapping the distribution of empty lacunae within a femoral head. an algorithm is here described that automatically identifies the locations of osteocyte-filled vs. empty lacunae. the algorithm is applied to necrotic lesions surgically induced in the emu, a lar ...200414965877
magnetite-containing spherical silica nanoparticles for biocatalysis and bioseparations.the simultaneous entrapment of biological macromolecules and nanostructured silica-coated magnetite in sol-gel materials using a reverse-micelle technique leads to a bioactive, mechanically stable, nanometer-sized, and magnetically separable particles. these spherical particles have a typical diameter of 53 +/- 4 nm, a large surface area of 330 m(2)/g, an average pore diameter of 1.5 nm, a total pore volume of 1.427 cm(3)/g and a saturated magnetization (m(s)) of 3.2 emu/g. peroxidase entrapped ...200414987087
treating inflammation: some (needless) difficulties for gaining acceptance of effective natural products and traditional medicines.the quality of so-called 'natural medicines' is extraordinarily variable. lack of resolute pharmacological assays contributes to this hiatus. more stringent evaluation of anti-inflammatory and anti-pyretic activities in rats can help resolve some of the uncertainties surrounding (a) preparations of some herbal products including so-called 'nature's aspirin' (e.g. willowbark, ginger), cat's claw, celery seed, etc., and (b) some animal lipids (e.g. lyprinol(r) (nz mussel), emu and fish oils). thes ...200315035737
gene therapy for lysosomal storage diseases: the lessons and promise of animal models.there are more than 40 different forms of inherited lysosomal storage diseases (lsds) known to occur in humans and the aggregate incidence has been estimated to approach 1 in 7000 live births. most lsds are associated with high morbidity and mortality and represent a significant burden on patients, their families, and health care providers. except for symptomatic therapies, many lsds remain untreatable, and gene therapy is among the only viable treatment options potentially available. therapies ...200415133760
synthesis of zerovalent nanophase metal particles stabilized with poly(ethylene glycol).concurrent sonolysis of iron pentacarbonyl and poly(ethylene glycol)-400 (peg-400) in hexadecane solvent proceeds via zero-order kinetics and results in fe nanoparticles encapsulated in peg-400 (fe-peg). the transmission electron microscopy images show fe-peg consisting of <3 nm fe particles that are evenly dispersed in the peg matrix. mössbauer and x-ray absorption fine structure/x-ray absorption near-edge structure data reveal an ordered peg assembly that helps protect the zerovalent fe core. ...200415274601
evaluation of magnetic behaviour and in vitro biocompatibility of ferritic pm2000 alloy.pm2000 is a ferritic alloy obtained by powder metallurgy and is being investigated for potential applications as a biomaterial. this work aimed to assess the biological compatibility and to determine the influence of the processing route and further recrystallisation treatment on the magnetic behaviour. the magnetic behaviour has been analysed as a function of the hysteresis loop obtained by using an inductive method. the biocompatibility has been tested using human osteoblast-like cells seeded ...200415386963
loss of one allele of arf rescues mdm2 haploinsufficiency effects on apoptosis and lymphoma development.the tumor suppressor p19arf inhibits mdm2, which restricts the activity of p53. complicated feedback and control mechanisms regulate arf, mdm2, and p53 interactions. here we report that arf haploinsufficiency completely rescued the p53-dependent effects of mdm2 haploinsufficiency on b-cell development, survival, and transformation. in contrast to mdm2+/- b cells, mdm2+/- b cells deficient in arf were similar to wild-type b cells in their rates of growth and apoptosis and activation of p53. conse ...200415467748
[preparation and feasibility of superparamagnetic dextran iron oxide nanoparticles as gene carrier].application of magnetic nano- particles as gene carrier in gene therapy of tumor has developed quickly. to obtain a new type non-viral gene introduction and therapy system,which is convenient,and can drive target gene to express highly and stably,this study was designed to explore the preparation of superparamagnetic dextran iron oxide nanoparticles(sdion),and the feasibility of sdion used as gene carrier in vitro.200415473917
identification of the major proteins of the organic matrix of emu (dromaius novaehollandiae) and rhea (rhea americana) eggshell calcified layer.1. the eggshell is a composite consisting of 95% calcite and an organic matrix. 2. while many proteins of the chicken eggshell matrix have already been identified, little is known about the matrix of other birds. 3. isolation of the emu and rhea eggshell matrix and analysis of its major constituents showed that the predominant components were c-type lectin-like proteins related to those of ostrich, chicken and goose. 4. serum albumin, vitelline membrane outer layer protein i (vmo-i) and the turp ...200415484722
magnetoswitchable controlled hydrophilicity/hydrophobicity of electrode surfaces using alkyl-chain-functionalized magnetic particles: application for switchable electrochemistry.magnetic nanoparticles consisting of undecanoate-capped magnetite (average diameter approximately 4.5 nm; saturated magnetization, m(s), 38.5 emu g(-1)) are used to control and switch the hydrophobic or hydrophilic properties of the electrode surface. a two-phase system consisting of an aqueous buffer solution and a toluene phase that includes the suspended capped magnetic nanoparticles is used to control the interfacial properties of the electrode surface. the magnetic attraction of the functio ...200415491206
id2 is dispensable for myc-induced lymphomagenesis.the emu-myc transgenic mouse appears to be an accurate model of human burkitt's lymphoma that bears myc/immunoglobulin gene translocations. id2, a negative regulator of basic helix-loop-helix transcription factors, has also been proposed as a myc target gene that drives the proliferative response of myc by binding to and overriding the checkpoint functions of the retinoblastoma tumor suppressor protein. targeted deletion of id2 in mice results in defects in b-cell development and prevents the de ...200415492249
rare beryllium icosahedra in the intermediate valence compound cebe13.single-crystal x-ray diffraction experiments show that the be atoms in cebe13 form a be12 icosahedra, which is a very unusual structural feature due, in part, to the remarkably low valence electron count of be. magnetization studies show that cebe13 displays intermediate valence behavior, in which valence fluctuations between the ce 4f0 and 4f1 states give rise to enhanced electronic specific heat and magnetic susceptibility. calculations using ab initio theory were used to determine the electro ...200415506745
the regulated long-term delivery of therapeutic proteins by using antigen-specific b lymphocytes.memory lymphocytes are important mediators of the immune response. these cells are long-lived and undergo clonal expansion upon reexposure to specific antigen, differentiating into effector cells that secrete ig or cytokines while maintaining a residual pool of memory t and b lymphocytes. here, the ability of antigen-specific lymphocytes to undergo repeated cycles of antigen-driven clonal expansion and contraction is exploited in a therapeutic protocol aimed at regulating protein delivery. the p ...200415520381
deregulated expression of the myc cellular oncogene drives development of mouse "burkitt-like" lymphomas from naive b cells.chromosomal translocations juxtaposing immunoglobulin (ig) and myc genes are the hallmarks of human burkitt lymphoma (bl), with deregulated myc expression being a critical factor in pathogenesis. by inserting an intact mouse myc gene into the mouse genome, proximal to the ig enhancer emu, the effect of a precise mimic of the major t(8;14) translocation of human endemic bl (ebl) could be investigated. knock-in mice developed igm-positive b-cell tumors, with most being typical of ebl by histology ...200515522957
cis-acting regulatory sequences promote high-frequency gene conversion between repeated sequences in mammalian cells.in mammalian cells, little is known about the nature of recombination-prone regions of the genome. previously, we reported that the immunoglobulin heavy chain (igh) mu locus behaved as a hotspot for mitotic, intrachromosomal gene conversion (gc) between repeated mu constant (cmu) regions in mouse hybridoma cells. to investigate whether elements within the mu gene regulatory region were required for hotspot activity, gene targeting was used to delete a 9.1 kb segment encompassing the mu gene prom ...200415528639
complex biallelic igh rearrangements in igm-expressing z-138 cell line: involvement of downstream immunoglobulin class switch recombination.chromosomal translocations involving the immunoglobulin (ig) receptor loci usually disrupt and silence these loci. on the basis of observations in follicular lymphoma (fl) with downstream ig heavy chain (igh) class switch recombination (csr), we hypothesized that downstream csr-mediated chromosomal translocations would leave the v(d)j-cmu transcription unit intact, thereby still allowing igm expression from the igh allele involved in the translocation. to test this hypothesis, we analyzed bialle ...200515543623
bcl-2 overexpression leads to increases in suppressor of cytokine signaling-3 expression in b cells and de novo follicular lymphoma.the t(14;18)(q32;q21), resulting in deregulated expression of b-cell-leukemia/lymphoma-2 (bcl-2), represents the genetic hallmark in human follicular lymphomas. substantial evidence supports the hypothesis that the t(14;18) and bcl-2 overexpression are necessary but not solely responsible for neoplastic transformation and require cooperating genetic derangements for neoplastic transformation to occur. to investigate genes that cooperate with bcl-2 to influence cellular signaling pathways importa ...200415561778
[effects of topical emu oil on wound healing in scalded rats].to observe the effect of topical emu oil on wound healing in scalded rats.200415567771
preparation of ferrimagnetic magnetite microspheres for in situ hyperthermic treatment of cancer.ferrimagnetic microspheres 20-30 microm in diameter are useful as thermoseeds for inducing hyperthermia in cancers, especially for tumors located deep inside the body. the microspheres are entrapped in the capillary bed of the tumors when they are implanted through blood vessels and heat cancers locally by their hysteresis loss when placed under an alternating magnetic field. in the present study, preparation of magnetite (fe(3)o(4)) microspheres 20-30 microm in diameter was attempted by melting ...200515585224
search for doubly charged higgs bosons decaying to dileptons in pp collisions at square root of s=1.96 tev.we present the results of a search for doubly charged higgs bosons (h+/-+/-) decaying to dileptons (ll(')) using approximately 240 pb(-1) of pp collision data collected by the cdf ii experiment at the fermilab tevatron. in our search region, given by same-sign ll(') mass m(ll('))>80 gev/c(2) (100 gev/c(2) for ee channel), we observe no evidence for h+/-+/- production. we set limits on sigma(pp -->h++h---->l(+)l('+)l(-)l('-)) as a function of the mass of the h+/-+/- and the chirality of its coupl ...200415601082
[magnetic parameters of the bees apis mellifera mellifera (l.) obtained by squid-magnetometry].it was found using squid-magnetometry that the dependence of the magnetization of a bee on the intensity of the applied magnetic fields has the form of a hysteresis loop. by using the parameters of the loop, the magnetic phases were identified and their characteristics were determined. it was found that the diamagnetic component is significant and has a susceptibility = -1,3335 x 10(-8) gs x cm3/oe. the ferromagnetite phase is represented by a multidomain magnetite with the coercive force of 70- ...200615612556
biodesulfurization using pseudomonas delafieldii in magnetic polyvinyl alcohol beads.to immobilize pseudomonas delafieldii r-8 cells in magnetic polyvinyl alcohol (pva) beads for biodesulfurization.200515612999
combining perimetric suprathreshold and threshold procedures to reduce measurement variability in areas of visual field loss.several current perimetric test strategies use information from neighboring test locations to seed the procedure. when this initial estimate is close to the true threshold, the algorithms terminate quickly with low error. however, when neighboring thresholds are dissimilar, seeding procedures in this manner results in poor accuracy and repeatability. this study aims to develop a test procedure that avoids assumptions based on neighboring locations yet terminates with an acceptable number of pres ...200515630403
synthesis, structure, and magnetism of a 1d compound engineered from a biradical [5,5'-bis(3''-oxide-1''-oxyl-4'',4'',5'',5''-tetramethylimidazolin-2''-yl)-2,2'-bipyridine] and mn(ii)(hfac)2.the synthesis, crystal structure, and magnetic properties of a one-dimensional compound, {[mn(hfac)2]2(biradical)}n (1), resulting from the coordination of bis(hexafluoroacethylacetonato)manganese(ii) [mn(hfac)2] with a biradical obtained by grafting two nitronyl nitroxide radicals in the 5 and 5' positions of a 2,2'-bipyridine ligand are described. compound 1 crystallizes in the triclinic p space group with the following parameters: a = 11.905(2) a, b = 12.911(2) a, c = 20.163(3) a, alpha = 73. ...200515679395
[effects of emu eggshell on sexual function of male mice].to investigate the effects of emu (dromaius novaehollandiae) eggshell produced in guangdong on sexual ability of male mice.200515699007
mdm2 splice variants and their therapeutic implications.mdm2 splice variants have now been identified in many different tumor types, and their expression has been associated with advanced disease. however, published data concerning their function is contradictory, and therefore their role in tumorigenesis and their potential as a therapeutic target are unclear. expression of a specific splice variant, mdm2-b, in a transgenic mouse model results in tumor development; and expression of several splice variants has been shown to enhance tumor formation i ...200515720186
ferromagnetic ordering of fe(iii) d spins of febr4- ions in (ethylenedithiotetrathiafulvalenothioquinone-ethylenedithio-1,3-dithiolemethide) x febr4.the 1:1 salt of a new donor molecule, ethylenedithiotetrathiafulvalenothioquinone-ethylenedithio-1,3-dithiolemethide (1), with febr4- ion, 1 x febr4, was prepared and found to exhibit a room-temperature electrical conductivity of 4 x 10(-2) s cm(-1) and semiconducting behavior with an activation energy of 170 mev. the paramagnetic susceptibility obeyed the curie-weiss law with a curie constant of 4.42 emu k mol(-1) and a weiss temperature of +3.4 k, and below 15 k, this short-range ferromagnetic ...200515732952
insertion of c-myc into igh induces b-cell and plasma-cell neoplasms in mice.we used gene targeting in mice to insert a his(6)-tagged mouse c-myc cdna, myc(his), head to head into the mouse immunoglobulin heavy-chain locus, igh, just 5' of the intronic enhancer, emu. the insertion of myc(his) mimicked both the human t(8;14)(q24;q32) translocation that results in the activation of myc in human endemic burkitt lymphomas and the homologous mouse t(12;15) translocation that deregulates myc in certain mouse plasmacytomas. beginning at the age of 6 months, myc(his) transgenic ...200515735016
the novel ets factor tel2 cooperates with myc in b lymphomagenesis.the human ets family gene tel2/etv7 is highly homologous to tel1/etv6, a frequent target of chromosome translocations in human leukemia and specific solid tumors. here we report that tel2 augments the proliferation and survival of normal mouse b cells and dramatically accelerates lymphoma development in emu-myc transgenic mice. nonetheless, inactivation of the p53 pathway was a hallmark of all tel2/emu-myc lymphomas, indicating that tel2 expression alone is insufficient to bypass this apoptotic ...200515743832
evolution of transcriptional enhancers in the immunoglobulin heavy-chain gene: functional characteristics of the zebrafish emu3' enhancer.past studies of the channel catfish immunoglobulin heavy-chain (igh) locus indicates that it lacks an emu enhancer in the j(h)-cmu1 intron but does have an enhancer, termed emu3', in the mu-delta intergenic region. the positioning of the catfish enhancer downstream of the mu-chain exons is predicted to be unfavorable for antibody-affinity maturation in catfish, and would also have been an impediment to the evolution of class switch recombination, had it existed in early tetrapods. to determine i ...200515756545
histone deacetylase inhibitor trichostatin a reduces anti-dna autoantibody production and represses igh gene transcription.systemic lupus erythematosus is characterized by the presence of autoantibodies and hypergammaglobulinemia. to investigate the role of histone deacetylases (hdacs) in the production of autoantibody and immunoglobulin, we examined the effect of trichostatin a (tsa), a specific inhibitor of hdacs, on anti-dna autoantibody production and igh gene transcription. our results showed that inhibition of hdac activity by tsa markedly reduced anti-dna autoantibody production by t347 cells either by induci ...200515781251
preparation and solid-state characterization of the novel mixed biradical *nsnsc-cnssn*.reduction of the radical-cation [*nssnc-cnsns][asf(6)] with ferrocene affords the novel biradical *nsnsc-cnssn* containing both 1,2,3,5- and 1,3,2,4-isomeric dithiadiazolyl rings. biradicals form centrosymmetric dimers with pi(*)-pi(*) interactions between different isomeric rings. biradical *nsnsc-cnssn* is diamagnetic in the solid state (c = 0.00035, tip = 6.5 x 10(-)(5) emu/oe.mol); however, an increase in paramagnetism was observed upon grinding (c = 0.003, tip = 4.2 x 10(-)(4) emu/oe.mol).200515819539
recurrent chromosomal aberrations in ink4a/arf defective primary lymphomas predict drug responses in vivo.predicting responsiveness to anticancer therapy based on molecular findings at diagnosis is important to optimize treatment decisions. although clinical outcome correlates with distinct mutations in some cancer entities, treatment responses within these lesion-stratified subgroups still remain heterogeneous, underscoring the need for additional prognosticators. we previously demonstrated that defined genetic defects at the ink4a/arf locus, which encodes the tumor suppressors p16ink4a and arf, no ...200515824738
second intermediate host land snails and definitive host animals of brachylaima cribbi in southern australia.this study of infection of southern australian land snails with brachylaima cribbi metacercariae has shown that all commonly encountered native and introduced snails are susceptible second intermediate hosts. the range of infected snails is extensive with metacercariae-infected snails being present in all districts across southern australia. c. virgata has the highest average natural metacercarial infection intensity of 6.1 metacercariae per infected snail. the susceptibility of birds, mammals a ...200515828579
mechanical counter-pressure vs. gas-pressurized spacesuit gloves: grip and sensitivity.an elastic mechanical counter pressure (mcp) glove for spacesuits is under development. in this study we compared handgrip and pinch grip strength levels for the mcp glove and the current extravehicular mobility unit (emu) gas-pressurized glove.200515828639
[anti-inflammatory activity and healing-promoting effects of topical application of emu oil on wound in scalded rats].to investigate the effects of topical application of emu oil on wound healing in scalded rats.200515837639
measurement of the ww production cross section in pp collisions at square root[s]=1.96 tev.we present a measurement of the w boson pair-production cross section in pp collisions at a center-of-mass energy of sqrt[s]=1.96 tev. the data, collected with the run ii d0 detector at fermilab, correspond to an integrated luminosity of 224-252 pb(-1) depending on the final state (ee, emu, or mumu). we observe 25 candidates with a background expectation of 8.1+/-0.6(stat)+/-0.6(syst)+/-0.5(lum) events. the probability for an upward fluctuation of the background to produce the observed signal is ...200515904132
nfkb 1 is dispensable for myc-induced lymphomagenesis.rel/nf-kappab transcription factors are critical arbiters of immune responses, cell survival, and transformation, and are frequently deregulated in cancer. the p50 nf-kappab 1 component of rel/nf-kappab dna-binding dimers regulates genes involved in both cell cycle traverse and apoptosis. nfkb 1 loss accelerates b cell growth and leads to increased b cell turnover in vivo, phenotypes akin to those manifested in b cells of emu-myc transgenic mice, a model of human burkitt lymphoma. interestingly, ...200515940251
successful initiation of combined therapy with valproate sodium injection and divalproex sodium extended-release tablets in the epilepsy monitoring unit.patients in epilepsy monitoring units (emus) often require aggressive initiation or reinitiation of therapy before discharge. we developed a simple dosing scheme using valproate sodium injection (vpa-iv) and divalproex sodium extended-release (vpa-er) tablets to minimize the time required for initiation of therapy, without increasing the likelihood of seizures and adverse effects.200515946337
mif loss impairs myc-induced lymphomagenesis.macrophage migration inhibitory factor (mif) is a potent regulator of inflammation and cell growth. using the emu-myc lymphoma mouse model, we demonstrate that loss of mif markedly delays the onset of b-cell lymphoma development in vivo. the molecular basis for this mif-loss-induced phenotype is the perturbed dna-binding activity of e2f factors and the concomitantly enhanced tumor suppressor activity of the p53 pathway. accordingly, premalignant mif-null emu-myc b-cells are predisposed to delaye ...200515947793
the world's longest surviving paediatric practices: some themes of aboriginal medical ethnobotany in australia.contemporary paediatric practices of australian aboriginal men and women, in more than 100 aboriginal language groups, comprise a living discipline whose origins predate western medicine by tens of millennia. the history of paediatrics acknowledges this surviving continuum of the world's oldest child-care practices. because of the inextricable nexus between aboriginal men and women and the land in which they live, medical ethnobotany forms a major part of the medical aspects of aboriginal child ...200715953330
therapeutically promising pna complementary to a regulatory sequence for c-myc: pharmacokinetics in an animal model of human burkitt's lymphoma.in burkitt's lymphoma (bl) cells c-myc is often translocated in proximity to the emu enhancer of the ig gene locus. this translocation causes c-myc hyperexpression and an increase in the cells' proliferative capacity. a peptide nucleic acid (pna) complementary to enhancer emu intronic sequence (pnaemu), linked to a nuclear localization signal (nls), selectively and specifically blocks the expression of the c-myc oncogene under emu control in vitro, suggesting potential therapeutic use. to explor ...200515989423
ecosystem collapse in pleistocene australia and a human role in megafaunal extinction.most of australia's largest mammals became extinct 50,000 to 45,000 years ago, shortly after humans colonized the continent. without exceptional climate change at that time, a human cause is inferred, but a mechanism remains elusive. a 140,000-year record of dietary delta(13)c documents a permanent reduction in food sources available to the australian emu, beginning about the time of human colonization; a change replicated at three widely separated sites and in the marsupial wombat. we speculate ...200516002615
biocompatible and biodegradable polymer nanofibers displaying superparamagnetic properties.superparamagnetic polymer nanofibers intended for drug delivery and therapy are considered here. magnetite (fe3o4) nanoparticles in the diameter range of 5-10 nm were synthesized in aqueous solution. polymer nanofibers containing magnetite nanoparticles were prepared from commercially available poly(hydroxyethyl methacrylate), phema, and poly-l-lactide (plla) by the electrospinning technique. nanofibers with diameters ranging from 50 to 300 nm were obtained. nanofibers containing up to 35 wt % m ...200516007710
synthesis of magnetic chelator for high-capacity immobilized metal affinity adsorption of protein by cerium initiated graft polymerization.a novel magnetic chelator with high adsorption capacity of protein by immobilized metal affinity adsorption was prepared by cerium (iv) initiated graft polymerization of tentacle-type polymer chains with iminodiacetic acid (ida) chelating group on magnetic particles with hydroxyl groups. the micron-sized magnetic poly(vinyl acetate-divinylbenzene) (pvac-dvb) particles were prepared by a modified suspension polymerization in the presence of oleic acid-coated magnetite nanoparticles and subsequent ...200516008413
biodesulfurization of dibenzothiophene by microbial cells coated with magnetite nanoparticles.microbial cells of pseudomonas delafieldii were coated with magnetic fe3o4 nanoparticles and then immobilized by external application of a magnetic field. magnetic fe3o4 nanoparticles were synthesized by a coprecipitation method followed by modification with ammonium oleate. the surface-modified fe3o4 nanoparticles were monodispersed in an aqueous solution and did not precipitate in over 18 months. using transmission electron microscopy (tem), the average size of the magnetic particles was found ...200516085841
complex regulation of somatic hypermutation by cis-acting sequences in the endogenous igh gene in hybridoma cells.to create high-affinity antibodies, b cells target a high rate of somatic hypermutation (shm) to the ig variable-region genes that encode the antigen-binding site. this mutational process requires transcription and is triggered by activation-induced cytidine deaminase (aid), which converts deoxycytidine to deoxyuridine. mistargeting of aid to non-ig genes is thought to result in the malignant transformation of b cells, but the mechanism responsible for targeting shm to certain dna regions and no ...200516087866
deposition feature of ni nanoparticles on halloysite template and magnetic properties of the composite.a novel cermet composite with ni nanoparticles deposited on a hollow cylindrical halloysite template is fabricated by electroless plating. ni nanoparticles have a uniform distribution on the template, and their average diameter is mainly in the range of 20-30 nm. the halloysite template will be beneficial to make the ni nanoparticles achieve high stability and well-dispersed state. different heat treatment temperatures have a great effect on the crystal structure of ni nanoparticles and the magn ...200516108436
insertion of myc into igh accelerates peritoneal plasmacytomas in mice.gene-targeted mice that contain a his6-tagged mouse c-myc cdna, myc(his), inserted head to head into different sites of the mouse immunoglobulin heavy-chain locus, igh, mimic the chromosomal t(12;15)(igh-myc) translocation that results in the activation of myc in the great majority of mouse plasmacytomas. mice carrying myc(his) just 5' of the intronic heavy-chain enhancer emu (strain imyc(emu)) provide a specific model of the type of t(12;15) found in a subset (approximately 20%) of plasmacytoma ...200516140930
chondroconductive potential of tantalum trabecular metal.mesenchymal stem cells or chondrocytes have been implanted into joints in biodegradable matrices in order to improve the quality of healing cartilage defects; however, insufficient biomechanical strength of the construct at implantation is a limiting factor for clinical application. logically, a construct with better biomechanical characteristics would provide better results. tantalum trabecular metal (ttm) is osteoconductive and mechanically similar to subchondral bone. the objective of this pi ...200516161110
seizures in the elderly: video/eeg monitoring analysis.recently there has been a remarkable increase in the number of elderly people with epilepsy due to the growing size of this segment of the population. the literature provides little information on the characteristics of epileptic and nonepileptic events in the elderly. therefore we report the results of video/eeg recordings in patients aged 60 or older admitted over 2 consecutive years to an epilepsy monitoring unit (emu).200516165402
structure and magnetic properties of (meso-tetraphenylporphinato)manganese(iii) bis(dithiolato)nickelates.the crystal structures of [mntpp]{ni[s2c2h(cn)]2} [mntpp = (meso-tetraphenylporphinato)manganese(iii)] and [mntpp]{ni[s2c2(cn)2]2} have been determined. these salts possess trans-mu-coordination of s = 1/2 {ni[s2c2h(cn)]2}*- and {ni[s(2)c(2)(cn)(2)](2)}*- to mn(iii) and form parallel 1-d coordination polymer chains exhibiting nu(cn) at 2210 and 2200 and 2220 and 2212 cm(-1), respectively. the bis(dithiolato) monoanions are planar and bridge two cations with mnn distances of 2.339(16), and 2.394( ...200516212379
expression of constitutively nuclear cyclin d1 in murine lymphocytes induces b-cell lymphoma.mantle cell lymphoma (mcl) is a b-cell lymphoma characterized by overexpression of cyclin d1 due to the t(11;14) chromosomal translocation. while expression of cyclin d1 correlates with mcl development, expression of wild-type (wt) cyclin d1 transgene in murine lymphocytes is unable to drive b-cell lymphoma. as cyclin d1 mutants that are refractory to nuclear export display heighten oncogenicity in vitro compared with wt d1, we generated mice expressing flag-d1/t286a, a constitutively nuclear mu ...200616247460
ccaat/enhancer binding protein alpha (c/ebpalpha) and c/ebpalpha myeloid oncoproteins induce bcl-2 via interaction of their basic regions with nuclear factor-kappab p50.the cebpa gene is mutated in 10% of acute myeloid leukemia (aml) cases. we find that cebpa and bcl-2 rna levels correlate highly in low-risk human amls, suggesting that inhibition of apoptosis via induction of bcl-2 by ccaat/enhancer binding protein alpha (c/ebpalpha) or its mutant variants contributes to transformation. c/ebpalphap30, lacking a nh2-terminal transactivation domain, or c/ebpalphalz, carrying in-frame mutations in the leucine zipper that prevent dna binding, induced bcl-2 in hemat ...200516254192
synthesis and characterization of nickel nanoparticles by hydrazine reduction in ethylene glycol.the synthesis of nickel nanoparticles by the hydrazine reduction of nickel chloride in ethylene glycol at 60 degrees c without soluble polymer as a protective agent was studied. it was found that an appropriate amount of naoh was necessary for the formation of pure nickel nanoparticles. also, it was not necessary to perform the reaction under a nitrogen atmosphere. by the analyses of x-ray diffraction, high-resolution transmission electron microscopy, and electron diffraction pattern, the result ...200316256507
mitochondrially targeted p53 has tumor suppressor activities in vivo.complex proapoptotic functions are essential for the tumor suppressor activity of p53. we recently described a novel transcription-independent mechanism that involves a rapid proapoptotic action of p53 at the mitochondria and executes the shortest known circuitry of p53 death signaling. here, we examine if this p53-dependent mitochondrial program could be exploited for tumor suppression in vivo. to test this, we engage emu-myc transgenic mice, a well-established model of p53-dependent lymphomage ...200516267022
synthesis, structure, and magnetic ordering of layered (2-d) v-based tris(oxalato)metalates.the reaction of k3[m(iii)(ox)3].3h2o [m = v (1), cr; ox = oxalate], mn(ii)/v(ii), and [n(n-bu)4]br in water leads to the isolation of 2-d v-based coordination polymers, [[n(n-bu)4][mn(ii)v(iii)(ox)3]]n (2), [[n(n-bu)4][v(ii)cr(iii)(ox)3]]n (3), [[n(n-bu)4][v(ii)v(iii)(ox)3]]n (4), and an intermediate in the formation of 4, [[n(n-bu)4][v(ii)v(iii)(ox)3(h2o)2]]n.2.5h2o (4a), while 1-d [v(ii)(ox)(h2o)2]n (5) is obtained by using na2ox and [v(oh2)6]so4 in water. the structures of 1-5 have been inves ...200516270982
molecular and cytological features of the mouse b-cell lymphoma line imycemu-1.myc-induced lymphoblastic b-cell lymphoma (lbl) in imycemu mice may provide a model system for the study of the mechanism by which human myc facilitates the initiation and progression of b cell and plasma cell neoplasms in human beings. we have recently shown that gene-targeted imycemu mice that carry a his6-tagged mouse myc cdna, mychis, just 5' of the immunoglobulin heavy-chain enhancer, emu, are prone to b cell and plasma cell tumors. the predominant tumor (approximately 50%) that arose in th ...200516277667
coexistence of focal and idiopathic generalized epilepsy in the same patient population.to review the clinical, electrographic, radiological, and pathological findings of patients with coexistent idiopathic generalized and partial epilepsy syndromes.200616352448
in vivo bone strain and ontogenetic growth patterns in relation to life-history strategies and performance in two vertebrate taxa: goats and emu.this study examined ontogenetic patterns of limb loading, bone strains, and relative changes in bone geometry to explore the relationship between in vivo mechanics and size-related changes in the limb skeleton of two vertebrate taxa. despite maintaining similar relative limb loads during ontogeny, bone strain magnitudes in the goat radius and emu tibiotarsus generally increased. however, while the strain increases in the emu tibiotarsus were mostly insignificant, strains within the radii of adul ...200616380928
amino acid sequences and phosphorylation sites of emu and rhea eggshell c-type lectin-like proteins.avian calcified eggshell layers contain in their organic matrix one or two c-type lectin-like proteins. previously characterized eggshell proteins of this family are chicken ovocleidin-17 (oc-17), goose ansocalcin and ostrich struthiocalcins 1 and 2 (sca-1, sca-2). in this report we present the amino acid sequences of two emu (dromaius novaehollandiae) (dromaiocalcin-1 and -2; dca-1, dca-2) and of two rhea (rhea americana) (rheacalcin-1 and -2; rca-1, rca-2) c-type lectin-like eggshell proteins, ...200616403478
effect of rapamycin on mouse chronic lymphocytic leukemia and the development of nonhematopoietic malignancies in emu-tcl1 transgenic mice.chronic lymphocytic leukemia (cll) is the most common leukemia in the world. the tcl1 gene, responsible for prolymphocytic t cell leukemia, is also overexpressed in human b cell malignancies and overexpression of the tcl1 protein occurs frequently in cll. aging transgenic mice that overexpress tcl1 under control of the mu immunoglobulin gene enhancer, develop a cd5+ b cell lymphoproliferative disorder mimicking human cll and implicating tcl1 in the pathogenesis of cll. in the current study, we e ...200616424025
anomalous magnetic properties of mechanically milled cobalt oxide nanoparticles.defect induced magnetic properties of coo nanoparticles produced via mechanical ball milling have been assessed by detailed magnetic measurements. a progressive decrease in the particle size and a concomitant increase in the induced strain have been observed with the milling times. the mechanically milled nanoparticles of coo exhibit anomalous magnetic properties such as fm hysteresis when compared with the unmilled coo sample. the presence of weak ferromagnetism, with a highest value of magneti ...200516430143
interaural timing difference circuits in the auditory brainstem of the emu (dromaius novaehollandiae).in the auditory system, precise encoding of temporal information is critical for sound localization, a task with direct behavioral relevance. interaural timing differences (itds) are computed using axonal delay lines and cellular coincidence detectors in nucleus laminaris (nl). we present morphological and physiological data on the timing circuits in the emu, dromaius novaehollandiae, and compare these results with those from the barn owl (tyto alba) and the domestic chick (gallus gallus). emu n ...200616435285
regulation of igh gene assembly: role of the intronic enhancer and 5'dq52 region in targeting dhjh recombination.the assembly of ag receptor genes by v(d)j recombination is regulated by transcriptional promoters and enhancers which control chromatin accessibility at ig and tcr gene segments to the rag-1/rag-2 recombinase complex. paradoxically, germline deletions of the igh enhancer (emu) only modestly reduce d(h)-->j(h) rearrangements when assessed in peripheral b cells. however, deletion of emu severely impairs recombination of v(h) gene segments, which are located over 100 kb away. we now test two alter ...200616456003
overexpressed bcl-x(l) prevents bacterial superantigen-induced apoptosis of thymocytes in vitro.bcl-x, a homologous gene of bcl-2, has an anti-apoptotic function and appears to play a critical role in the development of lymphoid systems. to investigate the effect of overexpressed bcl-x(l) on the development of t lymphocytes, we established two lines of transgenic mice by using emu-chicken bcl-x(l) (cbcl-x(l)) transgene, where the cbcl-x(l) protein was expressed mainly in lymphoid cells. although thymocytes and splenocytes from cbcl-x(l) transgenic mice are resistant to apoptosis in vitro, ...199716465222
plasma cell tumour progression in imycemu gene-insertion mice.the authors have recently reported that gene-targeted imyc(emu) mice that carry a his(6)-tagged mouse myc cdna, myc(his), just 5' of the immunoglobulin heavy-chain enhancer, emu, are prone to 'spontaneous' neoplasms of the b-lymphocyte lineage. the present study has used histological, immunohistochemical, and molecular genetic methods to investigate a subset of these neoplasms referred to as extraosseous plasmacytomas (pcts). it is shown that 20.8% (20/96) of tumour-bearing imyc(emu) mice on a m ...200616482495
ultrastructural evaluation of multiple pass low energy versus single pass high energy radio-frequency treatment.the radio-frequency (rf) device is a system capable of volumetric heating of the mid to deep dermis and selective heating of the fibrous septa strands and fascia layer. clinically, these effects promote dermal collagen production, and tightening of these deep subcutaneous structures. a new technique of using multiple low energy passes has been described which results in lower patient discomfort and fewer side effects. this technique has also been anecdotally described as giving more reproducible ...200616493679
measurement of campylobacter numbers on carcasses in british poultry slaughterhouses.an assessment of the proposed new international organization for standardization quantitative method for campylobacter was undertaken on poultry carcass samples collected after the chilling phase of processing. using a critical differences method, we determined the uncertainty associated with log-transformed campylobacter numbers by dual analyses of 346 samples collected from 22 processing plants located throughout the united kingdom. overall, using log-transformed campylobacter numbers that ran ...200616496586
cellular response to magnetic nanoparticles "pegylated" via surface-initiated atom transfer radical polymerization.a new method to pegylate magnetic nanoparticles with a dense layer of poly(poly(ethylene glycol) monomethacrylate) (p(pegma)) by surface-initiated atom transfer radical polymerization (atrp) is reported. in this approach, an initiator for atrp was first immobilized onto the magnetic nanoparticle surface, and then p(pegma) was grafted onto the surface of magnetic nanoparticle via copper-mediated atrp. the modified nanoparticles were subjected to detailed characterization using ftir, xps, and tga. ...200616529418
[preparation and characterization of superparamagnetic iron oxide nanoparticles].to determine the physical and magnetic properties of superparamagnetic iron oxide (spio) nanoparticle prepared in our laboratory and evaluate its possibility for use as contrast agents in magnetic resonance imaging (mri).200616546740
magnetic and catalytic properties of cu0.5zn0.5fe2o4 nanocrystallite powders.cu0.5zn0.5fe2o4 nanocrystallite powders (average size 13 nm) were synthesized from cu-zn spent catalyst (fertilizers) industries and ferrous sulfate wastes formed during iron and steel making. cu-zn catalyst (22.4% cu and 26.4% zn) was chemically treated with sulfuric acid at temperature 80 degrees c for 1 hr for the complete dissolving of copper and zinc into sulfate solution, then the produced solution was mixed with stoichiometric ratio of ferrous sulfate and the mixture was chemically precip ...200616573080
the magnetic field induced by the bodily tide in the core of the earth.the motion in the liquid core of the earth due to the bodily tide can induce a periodic magnetic field having the frequency sigma of the tide as well as multiple frequencies, including a steady term. the coupling coefficient for the steady term between the convectively inducing and induced fields is estimated to be of the order of sigmah(2)/lambda, where h denotes the height of the equilibrium tide, and lambda = 1/4pikappa, kappa denoting the electrical conductivity of the core. with sigma = 1.4 ...197116591922
transient magnetic effects in a scale model of the earth's core.scale model experiments are described in which the contribution to the dipole magnetic field of a conducting sphere (simulating the earth's core) by initially closed, internal flux loops is measured. a magnetic loop is maintained by constant current in a toroidal coil, in a mercury sphere. the circuit is then opened, which allows the magnetic loop to diffuse and dissipate. the time development of the magnetic effects outside the sphere is recorded, especially the contribution in the dipole mode ...197716592464
laser-assisted synthesis of superparamagnetic fe@au core-shell nanoparticles.a novel method combining wet chemistry for synthesis of an fe core, 532 nm laser irradiation of fe nanoparticles and au powder in liquid medium for deposition of an au shell, and sequential magnetic extraction/acid washing for purification has been developed to fabricate oxidation-resistant fe@au magnetic core-shell nanoparticles. the nanoparticles have been extensively characterized at various stages during and up to several months after completion of the synthesis by a suite of electron micros ...200616599475
synthesis of novel porous magnetic silica microspheres as adsorbents for isolation of genomic dna.an improved procedure is described for preparation of novel mesoporous microspheres consisting of magnetic nanoparticles homogeneously dispersed in a silica matrix. the method is based on a three-step process, involving (i) formation of hematite/silica composite microspheres by urea-formaldehyde polymerization, (ii) calcination of the composite particles to remove the organic constituents, and (iii) in situ transformation of the iron oxide in the composites by hydrogen reductive reaction. the as ...200616599570
algorithm architectures for patient dependent seizure detection.the goal of this work is to determine whether improved performance (compared to patient independent algorithms) can be achieved by an algorithm, developed on the fly, that requires no user input beyond the identification of the first one or two seizures in the record.200616600676
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