Publications
| Title | Abstract | Year Filter | PMID(sorted ascending) Filter |
|---|
| trypanosoma cruzi: cultivation in macromolecule-free semisynthetic and synthetic media. | 1978 | 365557 | |
| [differentiation by microimmunofluorescence of t. cruzi and t. cruzi-like strains from t. conorhini and t. rangeli, using protection from the sponge aaptos papillata (author's transl)]. | carbohydrates containing terminal nonreducting d n-acetylgalactosamin or d n-acetylglucosamin were identified at the cell surface of trypanosoma cruzi by an indirect immunofluorescence test using the lectin of the sponge aaptos papillata. with the method described in this study t. cruzi and t. cruzi-like strains are easy to distinguish from t. rangeli, but not from t. conorhini. the immunofluorescence test presented here may be very helpful for certain diagnostic problems. | 1978 | 366941 |
| in vitro and in vivo evaluation of the toxicity of 1,4-naphthoquinone and 1,2-naphthoquinone derivatives against trypanosoma cruzi. | the toxic effect of lapachol, beta-lapachone and several 1,2-naphthoquinone derivatives on the growth, viability and infectivity of trypanosoma cruzi were compared. beta-lapachone was the most active compound in vitro. no inhibition was observed in suspensions which contained inactivated foetal calf serum or rabbit haemoglobin solution. the infectivity of trypomastigotes in mice was not affected when cells were previously incubated with beta-lapachone or one of several other naphthoquinone deriv ... | 1978 | 367298 |
| growth of trypanosoma cruzi in vitro, unaffected by sodium salicylate. | 1978 | 367301 | |
| ceramide and inositol content of the lipopeptidophosphoglycan from trypanosoma cruzi. | 1978 | 369561 | |
| [wild reservoirs and vectors of trypanosoma cruzi. lxx. behavior of t. cruzi strains isolated from wild animals, in the ricman and robson test]. | 1978 | 370918 | |
| [the kinetoplast of trypanosoma cruzi during cell differentiation (proceedings)]. | 1978 | 373536 | |
| selective inhibition of k-dna synthesis of trypanosoma cruzi and leishmania tarentolae by berenil and ethidium bromide [proceedings]. | 1978 | 373537 | |
| [phospholipid metabolism in t. cruzi (proceedings)]. | 1978 | 373538 | |
| drugs inducing generation of free radicals in trypanosoma cruzi [proceedings]. | 1978 | 373539 | |
| [changes in the t. cruzi membrane induced by immune serum. i. phospholipid metabolism (proceedings)]. | 1978 | 373540 | |
| [characterization of sub-cellular fractions of trypanosomatidae (proceedings)]. | 1978 | 373541 | |
| trypanosoma cruzi cell surface proteins: identification of one major glycoprotein. | 1979 | 374115 | |
| evidence for the plasma membrane localization of carbohydrate-containing macromolecules from epimastigote forms of trypanosoma cruzi. | 1979 | 374124 | |
| isolation of trypanosoma cruzi from the blood of infected mice by column chromatography. | trypomastogotes of three strains of trypanosoma cruzi were isolated from the blood of infected mice employing lymphoprep for separation of the red blood cells and a column of deae cellulose for removal of white cells and platelets. an average recovery of 45 to 58 percent of actively motile, infective organisms, free of contaminating blood cells was obtained. protein and carbohydrate assays of the separated organisms revealed significant differences between the tulahuen, a reticulotropic strain, ... | 1979 | 375218 |
| [effect of hormones (progesterone and testosterone) on the pathogenicity of trypanosoma cruzi]. | 1978 | 375351 | |
| [comparative study of the pathogenicity of 4 strains of t. cruzi in white mice]. | 1978 | 375352 | |
| effect of polyamines on protein kinases activities from trypanosoma cruzi. | an interaction of polyamines with protein kinases activities from t. cruzi epimastigotes is demonstrated. spermine and spermidine and less pronounced putrescine are found to inhibit protein kinases activities. in the extract of t. cruzi three protein kinases are distinguished on account of molecular weight (greater than 200 000, 95 000 and 40 000) and preference for acceptor proteins (phosvitin and histones). especially the activity of the high molecular weight protein kinase which phosphorylate ... | 1979 | 375514 |
| activation of macrophages in vivo and in vitro. correlation between hydrogen peroxide release and killing of trypanosoma cruzi. | as reported previously, mouse peritoneal macrophages could be activated to kill intracellular trypomastigotes of trypanosoma cruzi, the agent of chagas' disease, in either of two ways: by immunizing and boosting the mice (3), or by culturing resident or inflammatory macrophages in spleen cell factor(s) (scf) in vitro (2). macrophages activated in vivo became less trypanocidal with time in culture, and cells activated in vitro lost trypanocidal capacity when csf was removed (2). in the present st ... | 1979 | 376774 |
| effect of purification by deae-cellulose column on infectivity of trypanosoma cruzi blood forms. | 1979 | 376814 | |
| characterization by sedimentation analysis of kinetoplast dna from trypanosoma cruzi at different stages of culture. | the kinetoplast dna networks of trypanosoma cruzi exist under two forms which have been studied by equilibrium density centrifugation in cscl gradients containing ethidium bromide and by band sedimentation analysis. the relative proportion of the two forms has been measured and varies significantly between the exponential and stationary phase of growth, suggesting that one of these forms is a replicative intermediate. both forms exhibit very high sedimentation coefficients. the sedimentation vel ... | 1979 | 377236 |
| epoxide hydrase in trypanosoma cruzi epimastigotes. | 1. microsomal fractions from trypanosoma cruzi epimastigotes catalyze the hydration of styrene oxide to styrene glycol. the activity is linear up to 45 min of incubation, is proportional to microsomal protein concentration within certain range, and has an optimum ph of 8.5. 2. double-reciprocal plots indicate a km value of 5.3 . 10(-4) m for styrene oxide and a v of 29.6 pmol of styrene glycol formed/min per mg protein at 37 degrees c. 4-chlorophenyl-2,3-epoxypropyl either (ki = 2.08 . 10(-4) m) ... | 1979 | 378266 |
| trypanosoma cruzi: defined medium for continuous cultivation of virulent parasites. | 1979 | 378678 | |
| [trypanosoma cruzi in cultures of spinal ganglia of chick embryo, seen in intereference contrast and electron microscopy (proceedings)]. | 1979 | 380424 | |
| a re-examination of purine and pyrimidine synthesis in the three main forms of trypanosoma cruzi. | 1979 | 383542 | |
| a morphological study of the interaction between trypanosoma cruzi and rat eosinophils, neutrophils and macrophages in vitro. | the interaction between trypomastigotes of t. cruzi and purified rat eosinophils, neutrophils and macrophages has been studied. macrophages induced by dextran, became infected and the parasites multiplied as amastigotes, eventually being released as trypomastigotes into the medium. eosinophils show an antibody-dependent phagocytosis, while neutrophil phagocytosis is enhanced by antibody. electron microscopy showed that once inside the granulocyte phagosome, the trypomastigotes transform to amast ... | 1979 | 383733 |
| electron microscopic study of trypanosoma cruzi. | 1979 | 383971 | |
| acetate oxidation by bloodstream forms of trypanosoma cruzi. | bloodstream forms of trypanosoma cruzi had a substantial increase in respiration in the presence of acetate. oxidation of acetate took place via the tricarboxylic acid cycle and involved an antimycin a-sensitive respiratory pathway. oxygen uptake in the presence of acetate was a sensitive to antimycin a inhibition as was co2 production. there was a 6--7% residual o2 uptake which was not inhibited by high antimycin concentrations. human anti-t. cruzi sera had no effect on oxygen uptake. | 1979 | 385857 |
| isolation of pure metacyclic trypomastigotes of trypanosoma cruzi from triatomine bugs by use of a deae-cellulose column. | 1979 | 390110 | |
| [effect of antimycin a on the respiration and growth of trypanosoma cruzi]. | 1979 | 390297 | |
| two forms of 'malic' enzyme with different regulatory properties in trypanosoma cruzi. | 1. cell-free extracts from culture epimastigotes of trypanosoma cruzi contained two forms of nadp+-linked 'malic' enzyme (ec 1.1.1.40), i and ii, with the same molecular weight but different electrophoretic mobilities and kinetic and regulatory properties. 2. the apparent km for l-malate was lower for 'malic' enzyme i, with hyperbolic kinetics, whereas the kinetic pattern for 'malic' enzyme ii was slightly sigmoidal (h 1.4). the kinetics for nadph were hyperbolic for 'malic' enzyme i, and very c ... | 1979 | 393256 |
| antibody-induced capping of the intracellular stage of trypanosoma cruzi. | intracellular-stage trypanosoma cruzi were isolated from infected mice. the effect of specific human antibodies on the membrane surface antigens was studied in vitro, using the immunofluorescent technique. the immune serum induced the aggregation of surface antigens, forming polar caps on the amastigotes. | 1979 | 393632 |
| [immunoenzymatic diagnosis (elisa) of human african trypanosomiasis. (a comparative study of several antigens) (author's transl)]. | a comparative study, by elisa, of purified exoantigen and of five crude antigenic extracts from several strains of t.b. gambiense and t.b. brucei has shown a wide range of results. the best sensitivity is obtained with virulent strains from human origin. for more accuracy, an association of such antigens would be preferable. | 1979 | 393937 |
| [lectin receptors on the surface of trypanosoma cruzi epimastigotes]. | 1979 | 393950 | |
| purine metabolism in trypanosomatids. | purine nucleotide biosynthesis was studied in culture forms of trypanosoma cruzi strain y, crithidia deanei (a reduviid trypanosomatid with an endosymbiote) and an aposymbiotic strain of c. deanei (obtained by curing c. deanei with chloramphenicol). trypanosoma cruzi was found to synthesize purine nucleotides only fring incorporated into both adenine and guanine nucleotides. similar results were obtained with guanine, indicating that this flagellate has a system for the interconversion of purine ... | 1979 | 395295 |
| [studies on the persistence of the infectivity of trypanosoma cruzi. ii. persistence of infectivity of t. cruzi in dead bugs (author's transl)]. | investigations into the viability time of t. cruzi in dead bugs experimentally infected with "peru" strain showed a maximum of 9 days for dipetalogaster maximus and 8 for triatoma infestans maintained at ambient temperature (26 degrees c). on refrigeration survival was increased to 60 days. in routine xenodiagnosis in the refrigerator 90 day survival was noted of both t. cruzi and the vector bug. | 1979 | 396604 |
| trypanosoma cruzi: interaction with vertebrate cells. dna synthesis and growth of intracellular amastigotes and their relationship to host cell dna synthesis and growth. | dna synthesis of intracellular trypanosoma cruzi amastigotes, following the infection of bovine embryo skeletal muscle (besm) cells, was studied by autoradiography. after penetration, there was a prereplicative lag period (similar to or approximately 12 h) followed by a synchronous round of dna synthesis which was found to be independent of parasite number/besm cell cand the host cell dna synthesis cycle. parasite reproduction occurred, for the first time, at approximately 21 h postinfection. it ... | 1979 | 397342 |
| [insects and protozoa capable of inhibiting the breeding of triatomidae and the detection of trypanosoma cruzi in fecal material from triatomidae]. | 1977 | 397544 | |
| genetic modification of macrophage functions in relation to antibody responsiveness and resistance to infection. | 1979 | 397751 | |
| [various aspects of the behavior of wild strains of trypanosoma cruzi in mice and calomys callosus (rodentia)]. | 1979 | 398584 | |
| electronmicroscopic observations on lysis of trypanosoma cruzi epimastigote by normal rabbit serum. | the lytic effects of serum from a non-immunized rabbit on epimastigotes of trypanosome cruzi were studied by electronmicroscopy. the first detectable change was the appearance of a fuzzy deposit over the whole surface of the epimastigote. soon after this, pellicular microtubules disappeared without change of axonemal microtubules. circular lesions were observed by negative staining, corresponding to the lesion of antibody-mediated lysis caused by complement. | 1979 | 399585 |
| [chronic chagas myocarditis in mexico. 3d case confirmed by parasitoscopic examination]. | 1979 | 400305 | |
| glutamate dehydrogenase and aspartate aminotransferase in trypanosoma cruzi. | 1. the cultured, epimastigote-form of trypanosoma cruzi contains nadp-linked glutamate dehydrogenase (ec 1.4.1.4), with a molecular weight of about 280,000, similar to the enzyme from plasmodium chabaudi and different from the enzymes from higher animal sources. 2. t. cruzi also contains aspartate aminotransferase (ec 2.6.1.1), with properties similar to those of the enzyme from mammals. 3. the concerted action of the transaminase and glutamate dehydrogenase might be responsible for the producti ... | 1977 | 400947 |
| lipid composition of trypanosoma cruzi. | 1. lipid composition of trypanosoma cruzi epimastigote form in culture consist of 35% of phospholipids and 65% of neutral lipids. 2. among the phospholipids, phosphatidylcholine is the more abundant (44%), followed by phosphatidylethanolamine (28%), phosphatidylinositol (12%), sphingomyelin (4%), and smaller amounts of cardiolipin, phosphatidic acid, lysolecithin, phosphatidylserine (traces), and an unidentified phospholipid (3%). 3. pulse labeling with 32p showed highest specific incorporation ... | 1977 | 400952 |
| inhibition of the nadp-linked glutamate dehydrogenase from trypanosoma cruzi by sulfhydryl reagents. | 1. the nadp-linked glutamate dehydrogenase purified from epimastigotes of trypanosoma cruzi was strongly, but not completely, inhibited by sulfhydryl reagents, in the presence of tris-hcl or phosphate buffers. 2. the enzyme modified by preincubation with o-iodosobenzoate had a kinetic behaviour different from that shown by the enzyme modified with other inhibitors, such as n-ethylmaleimide or p-chloromercuribenzoate. 3. the inhibition by o-iodosobenzoate was additive with the inhibition by the o ... | 1979 | 400963 |
| immunosuppression and circulating trypanosoma cruzi in a kidney transplant recipient. | 1977 | 402046 | |
| trypanosoma cruzi: immune destruction of parasitized mouse fibroblasts in vitro. | 1977 | 402286 | |
| chagas' disease with cardiopathy and hemiplegia. | 1977 | 402619 | |
| human behaviour and the propagation of chagaś disease. | during 12 months, 26 households with 172 residents in são felipe, bahia, brazil, entertained 74 different guests who were potentially exposed to attack by panstrongylus megistus for an average of about 23 nights per guest per year. during the same period 52 of the residents spent an average of about two weeks a year away from home. these exchanges established contact with 79 other households in the district. these and other observations reinforce the opinion that human behaviour plays an importa ... | 1976 | 402723 |
| trypanosoma cruzi: infection of normal and activated mouse macrophages. | 1977 | 403086 | |
| the evi antibody in acute chagaś disease. | 1977 | 403265 | |
| [studies on wild reservoirs and vectors of trypanosoma cruzi. lxiii: natural infection of the marsupial caluromys lanatus ochropus (wagner, 1842) by t. cruzi]. | 1977 | 403576 | |
| [studies on wild vectors and reservoirs of trypanosoma cruzi. lxii: evolution of t. cruzi in the coelomic cavity of triatomines]. | 1977 | 403578 | |
| survival of arboviruses in trypanosome-infected triatomines. | the potential of triatomines to maintain arboviruses was demonstrated by the ability of rhodinius prolixus with experimentally punctured abdomen to harbor venezuelan equine encephalitis (vee) virus for at least 4 months and st. louis encephalitis virus for 1 month. at 30 days after infection vee virus was found at low titers in trypanosoma cruzi-infected r. prolixus and at moderate titers in t. rangeli-infected r. neglectus. transmission of vee virus by bite of punctured bugs was successful 2 we ... | 1977 | 403822 |
| cellular immunity in chronic chagas' disease. | the cellular immune response was assessed in 20 patients with chronic chagas' disease (american trypanosomiasis). thymus-derived lymphocyte function was determined in vivo by cutaneous reactivity to several antigens including a soluble preparation derived from trypanosoma cruzi and sensitization to 2,4-dinitrochlorobenzene. the in vitro t-cell reactivity was investigated by the proliferative response to phytohemagglutinin and to t. cruzi antigen and by inhibition of leukocyte migration with the ... | 1977 | 404317 |
| serological methods in the diagnosis of chagas' disease. | 1977 | 404735 | |
| effect of the injection of ribosomes and rna from crithidia fasciculata on the experimental infection of mice by trypanosoma cruzi. | immunization of mice with crithidia fasciculata (live suspension, ribosomal fraction and purified rna) induced a certain degree of protection (decrease of parasitaemia) against infection with trypanosoma cruzi. | 1977 | 404736 |
| immunization of mice against trypanosoma cruzi. the effect of size of dose, and route of injection, of immunizing and challenge inocula. | groups of cd-1 mice were immunized with a vaccine prepared from freeze-thawed cultured epimastigotes of trypanosoma cruzi, strain y, with or without saponin as adjuvant. the vaccine was injected by the subcutaneous (s.c.) or intraperitoneal (i.p.) route. immunized and control mice were challenged with homologous blood trypomastigotes by the s.c. or i.p. route and the former route was found to produce a far more severe and uniform infection in both control and immunized mice. subcutaneous challen ... | 1977 | 404742 |
| effect of length of treatment with bayer 2502 on isolation of trypanosoma cruzi and resistance to challenge in the mouse. | the effect of length of treatment of trypanosoma cruzi with bayer 2502 (bay 2502, lampit, nifurtimox) on resistance to challenge and parasite isolation was studied in two experiments. in each, 200 mice were divided into groups of 20, infected with t. cruzi, and then treated with bay 2502 for 1 to 8 consecutive weeks. sixteen weeks after exposure, 10 mice from each experimental group were challenged with 150,000 trypomastigotes. the remainder were maintaned for 8 more weeks and killed for isolati ... | 1977 | 405877 |
| antiprotozoal thiazoles. 2. 2-(5-nitro-2-furyl-, thiazolyl-, and 1-methylimidazolyl-)thiazoles. | ten 2-substituted 4-thiazolecarboxaldehyde hydrazones bearing 5-nitro-2-furyl, 5-nitro-2-thiazolyl, and 1-methyl-5-nitro-2-imidazolyl functions have been prepared and screened for activity against trypanosoma cruzi infections in mice. the results permitted the ranking of these substituents in decreasing order of activity: 1-methyl-5-nitro-2-imidazolyl greater than 5-nitro-2-furyl greater than 5-nitro-2-thiazolyl, the last being inactive. some structural features of the side chain necessary for o ... | 1977 | 406399 |
| [congenital chagas' disease]. | 2006 | 406498 | |
| [studies on wild disease reservoirs and vectors of trypanosoma cruzi: lxiv. natural infection of the rodent dasyprocta aguti (linnaeus, 1766) by t. cruzi]. | 1977 | 406645 | |
| [studies on the wild reservoirs and vectors of trypanosoma cruzi. lxv. natural infection of the monkey callithrix geoffroyi (humboldt, 1812) by t. cruzi]. | 1977 | 406646 | |
| gastric secretory and motility studies in chronic chagasic patients. | in chagas' disease, the degeneration of the nerve cells of the intramural parasympathetic ganglia of the stomach causes a wide range of motor and secretory disturbances of the organ. to assess and to correlate the alterations of these two gastric functions, electromanometric and secretory studies were performed in 22 chagasic patients and in 12 control individuals. the gastric antrum electromanometric records were carried out in basal conditions and under the stimulation of methacholine chloride ... | 1977 | 406781 |
| naturally occurring trypanosomiasis (chagas' disease) in dogs. | nine fatal cases of canine american trypanosomiasis (chagas' disease) were encountered from november, 1972, through november, 1975. of the 9 cases, 7 occurred in dogs from 5 central texas counties, and all but one case was diagnosed during the months of september, october, or november. the source of infection was discovered in only one case--that being a doghouse heavily infested with triatoma lectularius occulta. each of 6 bugs collected had infective forms of the protozoan, trypanosoma cruzi. ... | 1977 | 407202 |
| the identification by isoenzyme patterns of two distinct strain-groups of trypanosoma cruzi, circulating independently in a rural area of brazil. | culture forms of 17 trypanosoma cruzi stocks, primarily isolated from a rural area of endemic chagas disease at são felipe, bahia, brazil, were compared by the electrophoretic patterns of six enzymes: aspartate aminotransferase, alanine aminotransferase, glucose-6-phosphate dehydrogenase, malate dehydrogenase (decarb-oxylating) (nadp+), glucosephosphate isomerase and phosphoglucomutase. two markedly distinct combinations of isoenzyme patterns were seen, justifying the arrangement of the 17 stock ... | 1977 | 407674 |
| passive immunization of mice against trypanosoma cruzi using convalescent mouse serum. | groups of 10 mice were infected by the s.c. injection of blood trypomastigotes of trypanosoma cruzi, strains "y" and "tulahuen". they were injected i.p. with convalescent mouse-anti-t. cruzi serum (cmats) at various times. a single dose of cmats (y) was most effective when injected one day after homologous infection -31 of 40 mice survived the infection, whereas all controls, both untreated and injected with normal serum, died. cmats was significantly less effective in treating mice infected wit ... | 1977 | 407684 |
| suppression of cell-mediated immunity in experimental chagas' disease. | the effect of acute infection with the tulahuén strain of trypanosoma cruzi on the cellular immune response in swiss mice was studied. mice were immunized with either freund's complete adjuvant or oxazolone, a skin sensitizing agent, and subsequently skin-tested with either bcg protoplasm or oxazolone to detect delayed hypersensitivity. depression of the response to these antigens was observed in infected mice during the stage of marked parasitemia. mice which were responsive to oxazolone before ... | 1977 | 407736 |
| search for trypanosoma rangeli in endemic areas of trypanosoma cruzi in argentina and brazil. | because the presence of trypanosoma rangeli in argentina and brazil has not been confirmed, a serach was carried out in man and triatomine insects. fifty-nine of 207 persons (28.5%) were infected when studied with one or more xenodiagnosis (40 triatoma infestans/xenodiagnosis); 0.1% to 13% of 7,821 bugs' feces and 4% of 875 dissected midguts showed t. cruzi in giemsa stained smears. one of 6,980 hemolymph samples and 1/875 salivary glands showed few flagellates which may have originated in the g ... | 1977 | 407809 |
| [natural infection of calomys musculinus (rodentia, cricetidae) by trypanosoma cruzi]. | in the rural area of las higueras, río cuarto, córdoba, argentina, a trypanosoma was isolated from a wild rodent (c. musculinus). the trypanosome was classified as trypanosoma cruzi because of the following characteristics: morphology as described by hoare for the schizotrypanum sub-genus: thin shaped, pointed back end, nucleus placed approximately in the middle of the body, prominent and subterminal kinetoplast and short free flagellum. the size measurements were as follows: total lengh 22.02 + ... | 1977 | 408884 |
| [serologic prevalence of chagas' disease in the southern area of the state of rio grande do sul (brazil)]. | 2006 | 408895 | |
| [experimental study on the resistance of a strain of trypanosoma cruzi to bay 2502]. | 1977 | 408896 | |
| [results of reactions for the diagnosis of chagas' disease performed on sera of patients with visceral leishmaniasis]. | 2006 | 408897 | |
| [pathogenesis of chagas' disease. special emphasis on the chronic aspect]. | 1977 | 410076 | |
| [leukocyte migration inhibition with soluble and particulate antigens (author's transl]. | studies were carried out with the leukocyte migration inhibition tests using soluble and particulate antigens (ppd, somatic antigens of t. cruzi, m. bovis (bcg) and leukocytes from patients sensitized to ppd and patients with chronic chagas' disease. the results obtained showed that the stimulatory capacity of particulate antigens are greater than that of soluble antigens. | 1977 | 410077 |
| protection against challenge of mice experimentally infected with trypanosoma cruzi. | 1977 | 410127 | |
| carlos chagas and chagas' disease. | 1977 | 410319 | |
| fixation of trypanosomatids for electron microscopy with the glutaraldehyde-tannic acid method. | epimastigotes from trypanosoma cruzi and promastigotes from herpetomonas samuelpessoai were fixed with glutaraldehyde-tannic acid. different concentrations of tannic acid were tested. with this technique the cellular membranes appear in negative contrast offering the same aspect as seen in cells fixed in glutaraldehyde only without post-fixation in osmium tetraoxide. an electron-dense deposit appears on the surface which possibly represents positively charged groups. the structure of the sub-pel ... | 1977 | 411272 |
| [supraventricular paroxysmal tachycardia with aberrant conduction in a patient with chagas' disease. report of a case]. | 1977 | 411460 | |
| an endemic focus of trypanosoma cruzi infection in a subhuman primate research colony. | leishmanial forms of trypanosoma cruzi with multifocal pseudocysts were identified in a deceased adult female rhesus monkey (macaca mulatta) that had been maintained in an outdoor primate colony in southern texas. subsequent clinical investigation of the remainder of the colony identified 20 additional monkeys seropositive for t cruzi. concurrent epizootiologic surveys confirmed the presence of sylvatic reservoirs and triatomine vectors of t cruzi infection and identified a natural t cruzi trans ... | 1977 | 411770 |
| pteridines. 41. synthesis and dihydrofolate reductase inhibitory activity of some cycloalka[g]pteridines. | a number of homologous 2,4-diaminocycloalka[g]pteridines varying in ring size from 5 to 15 were prepared by (a) condensation of aminomalononitrile tosylate with alpha-oximinocycloalkanones, deoxygenation of the resulting 2-amino-3-cyanocycloalka[b]pyrazine 1-oxides, and guanidine cyclization; (b) guanidine cyclization of the above pyrazine 1-oxides to give 2,4-diaminocycloalka[g]pteridine 8-oxides, followed by deoxygenation; or (c) condensation of 2,4,5,6-tetraaminopyrimidine with a cycloalka-1, ... | 1977 | 411935 |
| diagnosis of chagas' cardiomyopathy. non-invasive techniques. | the natural history of chagas' disease and its manifestations when the heart is involved are detailed clinically and pathologically. three phases are recognized: the acute phase, lasting from 1-3 months, the latent phase, which may last from 10-20 years, and the chronic phase, which has the most serious manifestations. this phase is subdivided into three clinical stages. an analysis of the varied cardiac manifestations on 235 patients is included. | 2004 | 412174 |
| trypanosoma cruzi infection in mice chronically infected with toxoplasma gondii. | 1977 | 412940 | |
| [trypanosoma cruzi: the action of specific rabbit immune serums on the growth of epimastigotes in diphasic media]. | 1977 | 413180 | |
| [serologic diagnosis of human trypanosoma cruzi infection. comparative study of complement fixation, immunofluorescence, hemagglutination and floculation tests in 3,624 serum samples]. | 1977 | 413181 | |
| tissue reacting ig in children parasitaemic with trypanosoma cruzi. | 1977 | 413220 | |
| immunoprophylaxis against chagas' disease. | 1977 | 413341 | |
| experiments on immunoprophylaxis against chagas' disease. | 1977 | 413342 | |
| immunofluorescent vascular pattern due to evi antibody of chagas' disease. its diagnostic value. | one hundred fifty-six of 1,250 sera from patients with presumed connective tissue and related diseases showed vascular staining on mouse liver cryostat sections when they were routinely checked for antinuclear factor by the indirect immunofluorescence test. in a third of the cases, the vascular immunofluorescent pattern was given by the evi antibody reacting with the plasma membrane of striated muscle fibers and endothelial cells, as has been recently described to occur in chagas' disease. this ... | 1978 | 413431 |
| a precipitin test for the diagnosis of human abdominal angiostrongyliasis. | a precipitin reaction was observed when sera of cotton rats infected either naturally or experimentally with angiostrongylus costaricensis were tested by gel double-diffusion against sera obtained from three biopsy-confirmed human cases of a. costaricensis. with immunoelectrophoresis, the antigen was demonstrated in the serum of infected rats. the antibody in the human serum was mostly of the igg type. no cross reactions were seen with sera from individuals infected with the common intestinal he ... | 1977 | 413446 |
| trypanosoma cruzi: uptake and intracellular fate in normal and activated cells. | 1977 | 413447 | |
| renin production in chagas' disease. | in six controls and ten patients with chagas' disease (trypanosomiasis cruzi), plasma renin activity was measured in peripheral venous blood, after 12 hours lying supine, and subsequently in an upright position at 5, 15, 30, 60 and 240 minutes. evidence of a postganglionic autonomic defect at the sympathetic efferent kidney innervation was observed, probably in two stages corresponding to the clinical form of the disease: the first (asymptomatic or intermediate clinical form) with high renin pro ... | 1977 | 413591 |
| trypanosoma cruzi: nifurtimox's effect on infectivity. | 1977 | 413732 | |
| isolation and properties of flagella of trypanosomatids. | a procedufe is described for the isolation of flagella of crithidia fasciculata, herpetomonas samuelpessoai and leishmania tarentolae in a highly purified state and giving reasonably good yield. the 3 types of flagella give a similar electrophoretic pattern of proteins. it is shown that h. samuelpessoai and, to a lesser extent, c. fasciculata flagella confer protection against trypanosoma cruzi infection. | 1977 | 413911 |
| exacerbation of experimental trypanosoma cruzi infection in mice by concomitant malaria. | the effect of malaria on the chronic phase of chagas' disease was investigated in mice. the animals were given plasmodium bergheri-infected red blood cells 2 to 12 months after their initial inoculation with trypomastigotes of 3 different strains of trypanosoma cruzi (y. cl and gilmar). in all the experiments carried out with one of the strains (cl), a somewhat variable but always considerable percentage of mice (average 39%) relapsed in to the acute phase of chagas' disease. this relapse was ch ... | 1977 | 413912 |
| antigens of the subcellular fractions of trypanosoma cruzi. ii. flagellar and membrane fraction. | a method for isolation of membrane and flagellar fractions from trypanosoma cruzi epimastigotes, and descriptions of their ultrastructural characteristics and antigenic activity are presented. electron-microscopic observation revealed that the membrane fraction resembled vesicles, as occurs frequently when the pressure-depressure method is used for cell disruption. the flagellar fraction revealed flagella and some membranes, both related and unrelated to the flagellar structure. flagellar and me ... | 1977 | 413914 |
| [congenital chagas' disease in the triângulo mineiro (report of a case)]. | 1977 | 414341 | |
| the sensitivity of culture methods to detect experimental infections of trypanosoma cruzi and comparison with xenodiagnosis. | 1977 | 414342 | |
| [the course of trypanosoma cruzi infection in nonsplenectomized spe rats with and without haemobartonella muris infection (author's transl)]. | rats were infected with h. muris from the first to the second week of their life. four weeks later 20 of the infected rats were inoculated with 1.5 x 10(5) t. cruzi. control animals were given the same number of parasites. in both experimental groups no hemoflagellate could be seen in blood smears four weeks after infection. the comparison of the course of infection of t. cruzi in rats with and without h. muris was made using t- and wilcoxon-test for pair differences. rats with h. muris infectio ... | 1977 | 414392 |
| cell-mediated immunity in chagas' disease: alterations induced by treatment with a trypanocidal drug (nifurtimox). | peripheral leucocyte migration inhibition (lmi) with trypanosoma cruzi-specific antigens, measured as a migration index (mi), was studied in chronic chagas' disease patients. the mi of untreated patients with polymerized antigens from culture forms (epimastigotes) of t. cruzi was significantly lower than that of controls. in contrast, when chronic chagas' patients were treated with nifurtimox, 10 mg/kg/day for 2 months, the mi was not different from control values. treated and untreated patients ... | 1977 | 414867 |