Publications
| Title | Abstract | Year Filter | PMID(sorted ascending) Filter |
|---|
| isopenicillin n synthetase of penicillium chrysogenum, an enzyme that converts delta-(l-alpha-aminoadipyl)-l-cysteinyl-d-valine to isopenicillin n. | the tripeptide delta-(l-alpha-aminoadipyl)-l-cysteinyl-d-valine, an intermediate in the penicillin biosynthetic pathway, is converted to isopenicillin n by isopenicillin n synthetase (cyclase) of penicillium chrysogenum. the cyclization required dithiothreitol and was stimulated by ferrous ions and ascorbate. co2+ and mn2+ completely inhibited enzyme activity. optimal temperature and ph were 25 degrees c and 7.8, respectively. the reaction required o2 and was stimulated by increasing the dissolv ... | 1985 | 3922296 |
| polyamine oxidases. | 1985 | 3926555 | |
| [physiological role of vegetable oils during penicillin biosynthesis]. | addition of liquid vegetable oils to nutrient media decreased the intensity of penicillin biosynthesis. the unfavourable effect of the oils was more pronounced at the beginning of the process while they were not completely utilized. sunflower oil is a readily assimilated source of carbon. the rate of its consumption is higher than that of whale oil or lactose. like the majority of readily oxidized sources of carbon, sunflower oil must be a repressor of beta-galactosidase and the enzymes of penic ... | 1985 | 3933416 |
| determination by high-performance liquid chromatography of some compounds involved in the biosynthesis of penicillin and cephalosporin. | a sensitive and convenient method for the simultaneous determination of several of the compounds involved in the biosynthesis of penicillin and cephalosporin is described. the method involves derivatization with a chiral fluorogen (o-phthaldialdehyde with an optically active thiol n-acetyl-l-cysteine), followed by high-performance liquid chromatography on a reverse-phase column as described by aswad (d. w. aswad, 1984, anal. biochem. 137, 405-409). with an analysis time of 1 h it was possible to ... | 1985 | 3934999 |
| [nucleic acid content during the germination of penicillium chrysogenum conidia]. | 1985 | 3935705 | |
| mycotoxins producing fungi and mycoflora of air-dust from taif, saudi arabia. | using the dilution plate method, 70 species and 31 genera were collected from 20 dust samples on glucose (28 genera and 64 species) and cellulose czapek's agar (22 genera and 46 species) at 28 degrees c. the most common fungi were aspergillus niger, a. flavus, a. flavus var. columnaris, phoma glomerata, fusarium oxysporum, penicillium chrysogenum and mucor racemosus; and a. nidulans, phoma humicola, drechslera spicifera and stachybotrys chartarum on the two media, respectively. toxicity test sho ... | 1985 | 3935928 |
| [dependence of the fatty acid composition of the lipids in fungi of the genus penicillium on their natural habitat conditions]. | the fatty acid composition of lipids was studied in penicillium fungi growing in different habitats. saturated fatty acids were represented by lauric, margaric, stearic and palmitic acids (the latter prevailed-- 18%-26%). unsaturated monoene fatty acids were represented by acids from c16:1 to c18:1, diene and triene fatty acids by linoleic and linolenic acids. the predominance of linoleic acid was not found in all cultures of the genus. changes in the fatty acid composition of lipids may be attr ... | 1985 | 3937035 |
| [quantitative dna and rna changes during the initiation of conidia in penicillium chrysogenum strain 9741]. | 1985 | 3937483 | |
| chemical and pharmacological studies of 2-(amino-methyl)acrylophenones. | the structure-activity relationships of nine products of the acrylophenone family have been studied. in a previous report 2-(4-methyl-1-piperazinylmethyl)acrylophenone was shown to be an antimicrotubular drug. the effects of these drugs on the bovine brain tubulin polymerization were determined by a turbidimetric assay. the median inhibitory concentrations (id50) ranged from 1.5 x 10(-5) to 5 x 10(-5) mol/l. their action on the inhibition of 3h-colchicine binding to tubulin was determined by dea ... | 1986 | 3954819 |
| an enzymatic differential assay for urinary diamines, spermidine, and spermine. | subsequent to the hydrolysis of urinary conjugated amines by heating with hydrochloric acid, free amines were isolated by cation-exchange chromatography. spd and spm in an aliquot of amine extract were first oxidized by pao from penicillium chrysogenum, producing put and hydrogen peroxide. dias, which consist of the initially present dias plus put produced by pao, were subsequently oxidized by puo from micrococcus rubens, producing hydrogen peroxide. in an another aliquot of the amine extract di ... | 1985 | 3980559 |
| evidence for two distinct intracellular pools of inorganic sulfate in penicillium notatum. | a strain of penicillium notatum unable to metabolize inorganic sulfate can accumulate sulfate internally to an apparent equilibrium concentration 10(5) greater than that remaining in the medium. the apparent keq is near constant at all initial external sulfate concentrations below that which would eventually exceed the internal capacity of the cells. under equilibrium conditions of zero net flux, external 35so42- exchanges with internal, unlabeled so42- at a rate consistent with the kinetic cons ... | 1985 | 3997782 |
| cultivation of fungi in synthetic and semi-synthetic liquid medium. i. growth characteristics of the fungi and biochemical properties of the isolated antigenic material. | four allergologically important fungi, viz. aspergillus fumigatus, alternaria penicillium notatum, and cladosporium herbarum, were cultured in a pure synthetic medium and the patterns of growth as characterized by the ph, protein and carbohydrate concentration of the culture fluid, were studied. a fumigatus and p. notatum showed a similar growth pattern, characterized by a rapid decrease in the ph of the culture medium (ph 7.4----4.0), while proteins were slowly released and saccharose poorly co ... | 1985 | 4091234 |
| enzymes of gluconate metabolism and glycolysis in penicillium notatum. | in addition to the ability of penicillium notatum to grow on sucrose, glucose, fructose and gluconate, substantial growth occurred on 2-ketogluconate and 5-ketogluconate thereby indicating a diverse sugar metabolism. cell-free extracts contained all the enzymes of the embden-meyerhof-parnas pathway and for both oxidative and non-oxidative pentose phosphate metabolism. despite inconsistencies in results between different assay methods for the conventional entner-doudoroff (ed) enzymes, the data i ... | 1985 | 4091540 |
| mitosis in penicillium chrysogenum and penicillium notatum. | 1971 | 4103466 | |
| [biosynthesis of peptide antibiotics]. | 1972 | 4117354 | |
| lytic plaque formation and variation in virus titre among strains of penicillium chrysogenum. | 1973 | 4124711 | |
| intracellular appearance of penicillium chrysogenum virus. | 1973 | 4126408 | |
| [actinomycin d-o]. | 1974 | 4142853 | |
| centrifugal freeze-drying of spores of penicillium chrysogenum wis 54-1255 from sodium glutamate. | 1972 | 4144846 | |
| proceedings: accelerated stability testing of freeze-dried preparations of penicillium chrysogenum wis54-1255. | 1973 | 4150535 | |
| cytochemical observations on the localization of sulphydryl groups in budding yeast cells and in the phialides of penicillium notatum westling during conidiation. | 1969 | 4189958 | |
| [effect of addition of fats on the intensity of perception of vital dyes by cells of penicillium chrysogenum]. | 1970 | 4191901 | |
| choline sulfatase of pseudomonas aeruginosa. | 1972 | 4196744 | |
| inhibition of cellular protein synthesis by double-stranded rna: inactivation of an initiation factor. | inhibition of protein synthesis in rabbit reticulocyte lysates by double-stranded rna is caused by the inactivation of if-3, an initiation factor required for the recycling of ribosomes and for their binding to messenger rna. the evidence for this is that (i) the inhibition can be overcome by addition of exogenous if-3; (ii) double-stranded rna inactivates stoichiometric amounts of if-3; (iii) double-stranded rna forms a complex with if-3; and (iv) double-stranded dna, which lacks inhibitory act ... | 1973 | 4197930 |
| penicillin production by lysine auxotrophs of penicillium chrysogenum. | 1973 | 4198715 | |
| [structure and biosynthesis of chrysogine, a metabolite of penicillium chrysogenum]. | 1973 | 4199763 | |
| effect of cycloheximide on l-leucine transport by penicillium chrysogenum: involvement of calcium. | cycloheximide (actidione) has an immediate inhibitory effect on amino acid transport by nitrogen-starved or carbon-starved mycelium suspended in phosphate buffer. high concentrations of phosphate alone are slightly inhibitory; cycloheximide appears to potentiate the effect of phosphate. ca(2+) reverses the inhibition of transport caused by phosphate plus cycloheximide. ca(2+) did not relieve the inhibition of protein synthesis. cycloheximide promotes a continual uptake of (45)ca(2+) by the mycel ... | 1973 | 4200128 |
| the production of interferon by chemostat cultures of mouse ls-cells grown in chemically-defined, protein-free medium. | 1973 | 4201834 | |
| formation and properties of protoplasts from antibiotic-producing strains of penicillium chrysogenum and cephalosporium acremonium. | 1973 | 4203925 | |
| the conversion of bisnorbiotin and bisnordethiobiotin to biotin and dethiobiotin, respectively, by microorganisms. | 1973 | 4204631 | |
| effect of fragmentation on interferon induction by double-stranded virus rna. | 1974 | 4208870 | |
| effect of exogenous penicillin on penicillin biosynthesis. | the addition of phenoxymethylpenicillin (10 mg/ml) at any time during the penicillin fermentation inhibited further accumulation of the antibiotic in broth but had no effect on growth. benzylpenicillin, 6-aminopenicillanic acid (6-apa), and some semisynthetic penicillins also showed this effect, but penicillin n, penicilloic acid, cephalosporin c, and 7-aminocephalosporanic acid did not limit penicillin accretion. incorporation of radioactive precursors (cysteine, valine, and sodium phenoxyaceta ... | 1972 | 4208897 |
| microbial models of mammalian metabolism. aromatic hydroxylation. | 1974 | 4209136 | |
| the relationship between hyphal branching, specific growth rate and colony radial growth rate in penicillium chrysogenum. | 1974 | 4209183 | |
| the genetics of penicillium chrysogenum. | 1973 | 4210250 | |
| formation and regeneration of penicillium chrysogenum protoplasts. | 1974 | 4211212 | |
| [comparative characteristics of the mutagenic effect of n-nitroso-n-methylbiuret and uv rays on a culture of penicillium chrysogenum]. | 1974 | 4211352 | |
| biochemistry of penicillin and cephalosporin fermentations. | 1974 | 4211838 | |
| detoxication of carboxin. | 1974 | 4211918 | |
| insensitivity of homocitrate synthase in extracts of penicillium chyrosogenum to feedback inhibition by lysine. | we previously reported that lysine inhibits in vivo homocitrate synthesis in the lysine bradytroph, penicillium chrysogenum l(1), and that such feedback inhibition could explain the known lysine inhibition of penicillin formation. in the present study, it was found that dialyzed cell-free extracts of mutant l(1) converted [1-(14)c]acetate to homocitrate. this homocitrate synthase activity was extremely labile but could be stabilized by high salt concentrations. the ph optimum of the reaction was ... | 1974 | 4212095 |
| penicillium endocarditis of aortic valve prosthesis. | 1974 | 4212231 | |
| the genetics of penicillium chrysogenum. | 1973 | 4212418 | |
| analysis of mathematical models of the effect of ph on fermentation processes and their use for calculating optimal fermentation conditions. | 1973 | 4212941 | |
| application of the continuous maximum principle to fermentation processes. | 1974 | 4212952 | |
| autodilution of fungal spore suspensions for viable counting. | 1974 | 4212960 | |
| kinetic model of secondary metabolite production and its use in computation of optimal conditions. | 1974 | 4213211 | |
| pancreatic ribonuclease: enzymic and physiological properties of a cross-linked dimer. | monomeric ribonuclease a has very low activity toward typically double-stranded rna's; the dimeric form of ribonuclease a obtained by cross linking the enzyme by dimethyl suberimidate has more than 78 times the activity of the monomer toward polyadenylate . polyuridylate and 440 times the activity of the monomer toward the double-stranded rna of a virus from penicillium chrysogenum. the half-life of the dimer in the bloodstream of the rat is 12 times that of the mononmer. | 1974 | 4213284 |
| the effect of fermentation conditions on the filtration characteristics of fermented broths. | 1974 | 4213430 | |
| [the fungal flora of the air in poultry houses]. | 1974 | 4213555 | |
| resistance of bacterial protein synthesis to double-stranded rna. | 1974 | 4214381 | |
| fungal growth rate and the formation of ethylene in soil. | 1974 | 4215868 | |
| alternate pathways of linolenic acid biosynthesis in growing cultures of penicillium chrysogenum. | 1974 | 4216304 | |
| [specificity of the intracellular rnase ii from aspergillus clavatus]. | 1974 | 4218762 | |
| [comparative study of the functions of metal phosphate polymers and condense polyphosphates in penicillium chrysogenum]. | 1973 | 4218853 | |
| [the relationship between the nitrogen metabolism of p. chrysogenum 194 and its mutant and penicillin biosynthesis]. | 1974 | 4219125 | |
| fractionation of nucleic acids from penicillium chrysogenum and associated ribonucleic acid viruses by selective exclusion and retention in agarose gels. | double-stranded nucleic acids from a strain of penicillium chrysogenum containing rna viruses were isolated by agarose-gel filtration, and separated into dna and double-stranded rna fractions by agarose-gel chromatography in 2.5m-nacl. the dna fraction contained less than 1% alkali-labile polynucleotides, and sedimented homogeneously at 8-10s in alkaline sucrose gradients. in cscl gradients it tended to band in the density region of 1.66-1.72g/ml. it had a ;melting' temperature (t(m)) of 75 degr ... | 1974 | 4219136 |
| exocellular deoxyribonuclease i of penicillium chrysogenum: i--partial purification & properties of the enzyme. | 1965 | 4222386 | |
| degeneration of penicillin titre in cultures of penicillium chrysogenum. | 1968 | 4231249 | |
| carbohydrate metabolism of penicillium chrysogenum spores. i. occurrence of tricarboxylic acid cycle enzymes in cell-free extracts of spores. | 1967 | 4233797 | |
| chorismate mutase isozyme patterns in three fungi. | 1973 | 4267751 | |
| a study of the kinetics of hyphal extension and branch initiation of fungal mycelia. | 1974 | 4274556 | |
| isolation and characterization of a double-stranded ribonucleic acid from penicillium chrysogenum. | double-stranded ribonucleic acid has been obtained from cells of the fungus penicillium chrysogenum. this ribonucleic acid appears to be associated with mycophage and is an efficient inducer of interferon its. extraction and partial purification are discussed, and evidence for its double-stranded and ribosidal nature is reviewed. the implications of viral nucleic acid in the life processes of fungi are considered. | 1970 | 4322084 |
| mutagenesis and enrichment of auxotrophs in penicillium chrysogenum. | an efficient method for isolation of auxotrophs of penicillium chyrysogenum involving mutagenesis with ethyl methanesulfonate followed by enrichment with sodium pentachlorophenate was developed. the auxotroph frequencies obtained were 30 to 40%. | 1972 | 4346628 |
| viruses with double-stranded rna genomes. | 1973 | 4355831 | |
| [localization of polymeric iron orthophosphate in penicillium chrysogenum]. | 1973 | 4357912 | |
| the effect of cyclic amp and related compounds on the control of protein synthesis in reticulocyte lysates. | 1974 | 4363751 | |
| [purification and properties of the extracellular alkaline phosphodiesterase of penicillium chrysogenum 152a]. | 1973 | 4364965 | |
| succinate dehydrogenases of mucor rouxii and penicillium duponti. | 1974 | 4371927 | |
| the effect of concentration, time and temperature on the viability of penicillium notatum spores exposed to phenols. | 1967 | 4383695 | |
| isolation and characterization of glutathione reductase from penicillium chrysogenum. | 1968 | 4386798 | |
| glutathione reductase-dependent metabolism of cysteine-s-sulfate by penicillium chrysogenum. | 1968 | 4386799 | |
| [biosynthesis of penicillins: formation of 5-(2-aminoadipyl)-cysteinyl-valine in extracts of penicillium chrysogenum]. | 1970 | 4394867 | |
| purification and properties of penicillium glucose 6-phosphate dehydrogenase. | 1. glucose 6-phosphate dehydrogenase was isolated and partially purified from a thermophilic fungus, penicillium duponti, and a mesophilic fungus, penicillium notatum. 2. the molecular weight of the p. duponti enzyme was found to be 120000+/-10000 by gelfiltration and sucrose-density-gradient-centrifugation techniques. no nadp(+)- or glucose 6-phosphate-induced change in molecular weight could be demonstrated. 3. glucose 6-phosphate dehydrogenase from the thermophilic fungus was more heat-stable ... | 1972 | 4404766 |
| substrate specificity of a highly purified phospholipase b from penicillium notatum. | 1974 | 4429696 | |
| uptake of mercuric chloride and methylmercury chloride from liquid media by aspergillus niger and penicillium notatum. | 1974 | 4433832 | |
| fat formation in preformed fungal mats of penicillium notatum. | 1974 | 4437588 | |
| isolation and characterization of glucose oxidase from mycelium and nutrient of penicillium notatum cultures. | 1974 | 4472163 | |
| properties of viruslike particles of penicillium chrysogenum: one double-stranded rna molecule per particle. | 1972 | 4622292 | |
| survey of microbial contamination of ophthalmic ointments. | 1972 | 4622497 | |
| storage of conidia of penicillium chrysogenum in liquid nitrogen. | conidiated slope cultures of derivative of penicillium chrysogenum wis 54-1255 were stored at -196 or +4 c for a period of 3.5 years. after this time, the viability fell to 68% in the former case and to 4% in the latter. at the end of the experiment, 65 single conidial isolates from each series were tested for penicillin yield. among those from conidia stored at -196 c, the spread of penicillin yields did not differ markedly from that of 65 single conidial isolates made as controls prior to stor ... | 1972 | 4624217 |
| the production of penicillins in soils and seeds by penicillium chrysogenum and the role of penicillin -lactamase in the ecology of soil bacillus. | 1972 | 4624991 | |
| [micorbiological hydroxylation of indolyl-3-acetic acid by fungi]. | 1972 | 4625327 | |
| an examination of penicillium notatum for the presence of penicillium chrysogenum-type virus particles. | 1972 | 4626436 | |
| lysine control of penicillin biosynthesis. | 1972 | 4627139 | |
| biological activity of double-stranded ribonucleic acid fragments. | 1972 | 4627731 | |
| mycoviruses: a new dimension in microbiology. | 1972 | 4628853 | |
| selected aspects of the biosynthesis of penicillins and cephalosporins. | 1972 | 4628918 | |
| binding of ethidium bromide to double-stranded ribonucleic acid. | 1973 | 4630220 | |
| on the mycophage of penicillium chrysogenum. | 1973 | 4631050 | |
| [various patterns in the biosynthesis of penicillins and penicillin-like substances]. | 1972 | 4631725 | |
| purification and some properties of lysophospholipase from penicillium notatum. | 1973 | 4631772 | |
| control of the general amino acid permease of penicillium chrysogenum by transinhibition and turnover. | 1973 | 4632118 | |
| effect of weak acids on amino acid transport by penicillium chrysogenum: evidence for a proton or charge gradient as the driving force. | a variety of weak acids at and below their pk(a) are potent inhibitors of transport in penicillium chrysogenum. the effective compounds include sorbate, benzoate, and propionate (common antifungal agents), indoleacetate (a plant hormone), acetylsalicylate (aspirin), hexachlorophene, and a yellow pigment produced by the mycelia under nutrient-deficient conditions, as well as the classical uncouplers 2,4-dinitrophenol, p-nitrophenol, and azide. the results suggest that a proton gradient or charge ... | 1973 | 4632394 |
| [detection of polymeric calcium, magnesium, and manganese orthophosphates in penicillium chrysogenum]. | 1973 | 4633438 | |
| diphasic production of secondary metabolites by penicillium notatum westling s-52. i. biosynthesis of eitrinin. | 1973 | 4687408 | |
| penicillium notatum catalase: purification and properties. | 1973 | 4707946 | |
| diphasic production of secondary metabolites by penicillium notatum westling s-52. ii. biosynthesis of fatty acids and lipids. | 1973 | 4710013 | |
| chemical changes in the cell walls of conidia of penicillium notatum during germination. | 1973 | 4727802 | |
| ultrastructural changes in the conidia of penicillium notatum during germination. | 1973 | 4727803 | |
| [purification and amino acid composition of the extracellular "alkaline" rnaase of penicillium chrysogenum 152a]. | 1973 | 4781626 |