Publications
| Title | Abstract | Year Filter | PMID(sorted ascending) Filter |
|---|
| evidence of lifetime susceptibility to tropheryma whipplei in patients with whipple's disease. | 2011 | 21393129 | |
| epidemiologic implications of the first isolation and cultivation of tropheryma whipplei from a saliva sample. | 2011 | 21403085 | |
| changing paradigms in whipple's disease and infection with tropheryma whipplei. | more than a century after its first description through g.h. whipple, the understanding of the chronic multisystemic infection called whipple's disease is still limited. however, within recent years the knowledge about diagnosis and treatment, the pathogenesis, and the biology of the agent itself have been improved by molecular biological and immunological methods. despite the ubiquitous presence of the causative bacterium tropheryma whipplei, whipple's disease is very rare, and immunogenetic ho ... | 2011 | 21461659 |
| infective endocarditis. | infective endocarditis (ie) is lethal if not aggressively treated with antibiotics alone or in combination with surgery. the epidemiology of this condition has substantially changed over the past four decades, especially in industrialized countries. once a disease that predominantly affected young adults with previously well-identified valve disease-mostly chronic rheumatic heart disease-ie now tends to affect older patients and new at-risk groups, including intravenous-drug users, patients with ... | 2011 | 21487430 |
| [thoraco-abdominal aortitis in ankylosing spondylitis: a case report and review of literature.] | we report a case of aortitis in a patient with ankylosing spondylitis revealed by an unexplained persistent inflammation. case study: the diagnosis of ankylosing spondylitis was retained in a 64-year-old woman suffering from inflammatory back and neck pain combined with buttock pain relieved by anti-inflammatory drugs (nsaids) since 2004 and more recent bilateral heel pain in the morning since 2006; sacroiliitis was grade 3 on the right and grade 2 on the left (modified new-york criteria). the p ... | 2011 | 21531097 |
| [diagnostic work-up in whipple's disease with cerebral involvement.] | the diagnostic work-up in the case of a suspected cerebral involvement of whipple's disease involves neuroimaging and analysis of cerebrospinal fluid (csf) including polymerase chain reaction (pcr) assays for tropheryma whipplei. as neurological findings may be complex and unspecific, extracerebral symptoms often lead to the suspicion of whipple's disease. we report the cases of two patients in whom the suspected diagnosis of whipple's disease could not be proved either by endoscopy or by the an ... | 2011 | 21544762 |
| an experimental mouse model to establish tropheryma whipplei as a diarrheal agent. | (see the editorial commentary by wilson et al, on pages 4-5.) tropheryma whipplei has long been considered as a rare bacterium causing a rare disease, whipple's disease. however, recent advances now suggest that t. whipplei is a ubiquitous environmental bacterium that may cause gastroenteritis, commonly associated with viral pathogens. we developed an animal model to support this hypothesis. we found that orally given t. whipplei induced diarrhea in mice, without spreading into the intestines. a ... | 2011 | 21628657 |
| [dementia in whipple's disease?: relevance of infectious etiologies]. | a 69-year old patient who had been treated for joint pain over a long time was admitted because of weight loss and dementia. he was confused and cachectic with edema and skin hyperpigmentation. | 2011 | 21656451 |
| [tropheryma whipplei infection : colonization, self-limiting infection and whipple's disease.] | whipple's disease is a multisystemic infection caused by the ubiquitous bacterium tropheryma whipplei. immunological host factors enable classical whipple's disease; however, t. whipplei can be found in three other clinical conditions: healthy colonization, self-limiting infections, and isolated endocarditis. the genetic predisposition of the host rather than the genotype of the bacterium influences the infection. modern diagnostic methods elucidate the many facets of whipple's disease. in part ... | 2011 | 21667114 |
| progressive dementia associated with ataxia or obesity in patients with tropheryma whipplei encephalitis. | tropheryma whipplei, the agent of whipple's disease, causes localised infections in the absence of histological digestive involvement. our objective is to describe t. whipplei encephalitis. | 2011 | 21676235 |
| whipple's disease: misdiagnosed as sarcoidosis with further tricuspid valve endocarditis and pulmonary embolism - a case report. | gh whipple described a 36-year-old physician in 1907 with gradual loss of weight and strength, stools consisting chiefly of neutral fat and fatty acids, indefinite abdominal signs and a peculiar multiple arthritis. the patient died of this progressive illness. whipple called it intestinal lipodystrophy since he observed accumulation of large masses of neutral fats and fatty acids in the lymph spaces. it was renamed whipple's disease in 1949. an infectious aetiology was suspected as early as whip ... | 2009 | 21686811 |
| reversible pulmonary hypertension in whipple disease: a case report with clinicopathological implications, and literature review. | whipple disease is a rare multisystemic disorder of infectious aetiology caused by tropheryma whipplei. pulmonary hypertension is a rare association for which the underlying pathophysiological mechanism is unclear. our patient was a 54-year-old man with a 1-year history of progressive polyarticular arthritis, and worsening respiratory and gastrointestinal symptoms. pulmonary artery catheterisation demonstrated moderate-to-severe pulmonary hypertension. duodenal biopsies, with electron microscopy ... | 2009 | 21686934 |
| isolated inctracranial whipple's disease-report of a rare case and review of the literature. | whipple's disease (wd) is a rare multisystemic infectious disease that can involve a variety of organs namely the gastrointestinal tract, lymphatic system, heart and nervous system. myorhythmia is a hallmark of wd. isolated cns involvement is very rare. | 2011 | 21696776 |
| complete resolution of primary sclerosing peritonitis ("abdominal cocoon") following long term therapy for tropheryma whipplei: a case report and review of literature. | a 53-year-old man was admitted to our internal medicine unit with intestinal obstruction and signs of systemic inflammatory disease. clinical history was unremarkable until a few months earlier, when he began suffering from achilles tendonitis. diagnostic procedures, including laparotomy, revealed diffuse thickening of the peritoneum resembling sclerosing encapsulating peritonitis. biopsies showed reactive fibrosis. no known secondary causes were found and surgery was technically not feasible. c ... | 2009 | 21709845 |
| a case of tropheryma whipplei infective endocarditis of the aortic and mitral valves in association with psoriatic arthritis and lumbar discitis. | whipple's disease is a chronic condition that is characterized by diarrhea, weight loss and arthropathy, and caused by infection with the fastidious bacterium tropheryma whipplei. although once rare, whipple's disease is being increasingly described owing mainly to advances in molecular genetics and an improved isolation of the organism. whilst cardiac whipple's disease occurs less commonly, especially in the absence of gastrointestinal symptoms, it has become apparent that some cases of culture ... | 2011 | 21714430 |
| [fever and arthritis: rheumatic or whipple's disease?]. | five years ago a 52-year-old patient presented with arthritis of the small and large joints. further symptoms were relapsing fever, unspecific gastrointestinal complaints with meteorism but no diarrhea, fatigue and impaired concentration. subsequently increasing lower back pain developed. a lumbar-disc lesion was already known. | 2011 | 21833885 |
| Contemporary unconventional clinical use of co-trimoxazole. | Clin Microbiol Infect 2012; 18: 8-17 ABSTRACT: In the late 1960s, the combination of trimethoprim and sulphamethoxazole (co-trimoxazole) was introduced into clinical practice and used to treat many infectious diseases, such as urinary tract infections, respiratory infections, sexually transmitted diseases, Gram-negative sepsis, enteric infections and typhoid fever. Subsequently, co-trimoxazole was reported to be effective against numerous bacterial, fungal and protozoal pathogens, including Noca ... | 2012 | 21851485 |
| comment on: evidence of lifetime susceptibility to tropheryma whipplei in patients with whipple's disease. | 2011 | 21856790 | |
| tropheryma whipplei aortic valve endocarditis without systemic whipple's disease. | culture-negative endocarditis is most often the result of prior antimicrobial therapy. tropheryma whipplei is the etiologic agent of whipple's disease, which is typically characterized by diarrhea, weight loss, and intra-abdominal lymphadenopathy. we present the case of a 48-year-old male with whipple's endocarditis of the aortic valve who did not develop signs of systemic whipple's disease. our patient was treated with a regimen that included ceftriaxone for 6 weeks prior to his cardiac surgery ... | 2011 | 21880531 |
| regulatory t cells in patients with whipple's disease. | classical whipple's disease (cwd) is caused by chronic infection with tropheryma whipplei that seems to be associated with an underlying immune defect. the pathognomonic hallmark of cwd is a massive infiltration of the duodenal mucosa with t. whipplei-infected macrophages that disperse systemically to many other organ systems. an alleviated inflammatory reaction and the absence of t. whipplei-specific th1 reactivity support persistence and systemic spread of the pathogen. in this article, we hyp ... | 2011 | 21918190 |
| In vitro activity of pentamidine against Tropheryma whipplei. | Pentamidine is a group I intron splice inhibitor used as a chemotherapeutic agent to treat parasitic infections. It was recently found to be efficient intracellularly against Coxiella burnetii, the bacterial agent of Q fever. This in vitro activity was linked to the presence of self-splicing group I introns that disrupt the 23S rRNA of C. burnetii. However, there are several indications that pentamidine may have a wider range of antibacterial activity. The aim of this study was to determine the ... | 2011 | 22005072 |
| whipple limbic encephalitis. | to describe a relapse of whipple disease revealed by isolated limbic encephalitis with no other signs of systemic involvement. | 2011 | 22084133 |
| treated whipple disease with erythema nodosum leprosum-like lesions: cutaneous pas-positive macrophages slowly decrease with time and are associated with lymphangiectases: a case report. | pathologically, whipple disease (wd) is characterized by the accumulation of myriad macrophages parasitized by tropheryma whipplei (tw) bacilli denoted by periodic acid-schiff (pas) positivity. these pas+ macrophages are typically found in the duodenum associated with lymphangiectasia. recently, we reported the presence of pas+ macrophages and free tw in erythema nodosum leprosum (enl)-like lesions and normal skin in a patient with wd who suffered from the immune reconstitution inflammatory synd ... | 2011 | 22123268 |
| high frequency of tropheryma whipplei in culture-negative endocarditis. | "classical" whipple's disease (cwd) is caused by tropheryma whipplei and is characterized by arthropathy, weight loss, and diarrhea. t. whipplei infectious endocarditis (twie) is rarely reported, either in the context of cwd or as isolated twie without signs of systemic infection. the frequency of twie is unknown, and systematic studies are lacking. here, we performed an observational cohort study on the incidence of t. whipplei infection in explanted heart valves in two german university center ... | 2011 | 22135251 |
| first isolation of tropheryma whipplei from bronchoalveolar fluid and clinical implications. | a patient presented diffuse pulmonary parenchymal micronodules. tropheryma whipplei was detected in the saliva, a bronchial biopsy and bronchoalveolar fluid. pas staining, immunohistochemistry and pcr for t. whipplei were negative in the duodenal biopsies. t. whipplei was isolated from the bronchoalveolar fluid, reinforcing its role as a respiratory pathogen. | 2011 | 22172770 |
| tropheryma whipplei: a common bacterium in rural senegal. | tropheryma whipplei is known as the cause of whipple's disease, but it is also an emerging pathogen, detected in stool, that causes various chronic localized infections without histological digestive involvement and is associated with acute infections, including gastroenteritis and bacteremia. | 2011 | 22206023 |
| a constricting differential--a case of severe anaemia, weight loss and pericarditis due to tropheryma whipplei infection. | 2014 | 22411875 | |
| ocular whipple's disease: therapeutic strategy and long-term follow-up. | to characterize the clinical features of ocular whipple's disease (wd) and determine the long-term prognosis after antibiotic treatment. | 2012 | 22420960 |
| tropheryma whipplei endocarditis without gastrointestinal involvement. | whipple's disease, caused by the bacterium tropheryma whipplei, is a rare chronic multi-system illness commonly affecting the gastrointestinal (gi) tract and presenting with a triad of diarrhoea, weight loss and malabsorption. while 20-55% of patients with a diagnosis of whipple's disease have clinically evident cardiac manifestations, the initial presentation with isolated valvular disease, without any gi symptoms, is rare. whereas cardiac involvement usually involves a single valve, cases of d ... | 2012 | 22499804 |
| [endocarditis caused by rare gram-positive bacteria: investigate for gastrointestinal disorders]. | gemella haemolysans, streptococcus equinus and tropheryma whipplei are rare gram-positive bacteria which may cause endocarditis and are associated with gastrointestinal disorders. we report on three patients with infective endocarditis caused by these microorganisms. g. haemolysans and s. equinus (streptococcus bovis group) were isolated from blood cultures, and t. whipplei was diagnosed by molecular typing of an excised heart valve. the association between endocarditis caused by these microorga ... | 2012 | 22607842 |
| intrafamilial circulation of tropheryma whipplei, france. | tropheryma whipplei, which causes whipple disease, has been detected in 4% of fecal samples from the general adult population of france. to identify t. whipplei within families, we conducted serologic and molecular studies, including genotyping, on saliva, feces, and serum from 74 relatives of 13 patients with classic whipple disease, 5 with localized chronic t. whipplei infection, and 3 carriers. seroprevalence was determined by western blot and compared with 300 persons from the general popula ... | 2012 | 22608161 |
| whipple disease revealed by lung involvement: a case report and literature review. | we report the case of a man with a history of intermittent fever and arthritis who presented with a dry cough and associated lung involvement, who was eventually given the diagnosis of whipple disease. the pulmonary symptoms preceded the development of gi manifestations. five years later, periodic acid-schiff (pas)-positive macrophages were identified in duodenal biopsy specimens and polymerase chain reaction for tropheryma whipplei was positive in the duodenum, stools, saliva, and cerebrospinal ... | 2012 | 22670021 |
| previous immunosuppressive therapy is a risk factor for immune reconstitution inflammatory syndrome in whipple's disease. | whipple's disease is a rare chronic infection caused by tropheryma whipplei. although most patients respond to antibiotics, in some of them the start of the treatment is followed by recurrence of inflammation. since polymerase chain reaction is negative for tropheryma whipplei, this reinflammation cannot be a relapse of whipple's disease itself. very recently, it has been recognised as a complication of whipple's disease and defined immune reconstitution inflammatory syndrome (iris). our aim is ... | 2012 | 22704397 |
| peripheral neuropathy in whipples disease: a case report. | whipples disease is a chronic multisystem inflammatory disease with predominantly gastrointestinal manifestations due to tropheryma whipplei infection. typical neurological abnormalities include dementia, eye movement abnormalities, hypothalamic dysfunction and oculomasticatory myorhythmias. the literature on peripheral neuropathy in whipples disease is sparse and the involvement of peripheral nerves in whipples disease has not been documented convincingly so far. we present a case of whipples d ... | 2012 | 22716061 |
| [whipple's disease: a case report]. | whipple's disease is a chronic, multisystem, infectious disease caused by tropheryma whipplei. it most commonly affects caucasian males, middle-aged. morbus whipple is primarily gastrointestinal disease, manifested as malabsorption syndrome, and diagnosed by endoscopy and intestinal biopsy. extraintestinal manifestations are not rare. | 2012 | 22779299 |
| tropheryma whipplei prevalence strongly suggests human transmission in homeless shelters. | 2013 | 22795221 | |
| cytokine genetic profile in whipple's disease. | whipple's disease (wd) is a very rare chronic systemic condition characterised by a th2/t regulatory (treg) dysregulated immune response versus tropheryma whipplei, a bacterium widely diffuse in the environment. to investigate whether this th2/treg polarised response has a genetic background, we investigated the th1, th2, th17 and treg cytokine genetic profile of 133 patients with wd. thanks to the european consortium on wd (qlg1-ct-2002-01049), the polymorphism of 13 cytokine genes was analysed ... | 2012 | 22847580 |
| central nervous system relapse of whipple's disease. | a 50-year-old man presented with a 12 kg weight loss in 8 months. upper gastrointestinal endoscopy findings showed strong erosion and diffuse bleeding in the duodenum. histopathological findings showed pas staining-positive macrophages consistent with whipple's disease. he was treated with trimethoprim-sulfamethoxazole. his condition initially improved. however, during his 6-year course of treatment he developed a central nervous system relapse. tropheryma whipplei dna was detected by a polymera ... | 2012 | 22864135 |
| [submucosal presentation of whipple's disease: a variant that is easily missed]. | whipple's disease is a multisystem, and often chronic, disease caused by infection with the bacterium tropheryma whipplei, and mainly occurs in middle-aged caucasian men. in most cases, histological detection of large numbers of bacteria-laden macrophages in the mucosa of the small intestine confirms the diagnosis. less commonly, these macrophages may be sparse and predominantly located beneath the mucosa. in these submucosally presenting cases, endoscopic and classic histological clues are abse ... | 2012 | 22971429 |
| whipple's disease: rare disorder and late diagnosis. | whipple's disease is a rare systemic infectious disorder caused by the bacterium tropheryma whipplei. we report the case of a 61-year-old male patient who presented to emergency room complaining of asthenia, arthralgia, anorexia, articular complaints intermittent diarrhea, and a 10-kg weight loss in one year. laboratory tests showed the following results: hb = 7.5 g/dl, albumin = 2.5 mg/dl, weight = 50.3 kg (bmi 17.4 kg/m²). upper gastrointestinal endoscopy revealed areas of focal enanthema in t ... | 2015 | 22983294 |
| tropheryma whipplei crystalline keratopathy: report of a case and updated review of the literature. | purpose. to report a case of tropheryma whipplei infection with crystalline keratopathy and review the recent literature on the presentation, diagnosis, and management of whipple's disease. methods. detailed case presentation and extensive literature search of pubmed for all years through february 2012 using the following search terms: whipple's disease, tropheryma whipplei, corneal deposits, crystalline keratopathy, and uveitis. relevant articles were retrieved and analyzed. english abstracts w ... | 2012 | 22988534 |
| the rise of tropheryma whipplei: a 12-year retrospective study of pcr diagnoses in our reference center. | tropheryma whipplei is the causative agent of classic whipple's disease (wd) and other clinical entities, such as localized infection. asymptomatic carriers have also been reported, mainly based on the testing of fecal samples. our objective was to undertake a retrospective analysis of molecular biology usage for the diagnosis of wd over a 12-year period in our reference center. we tested 27,923 samples from 15,473 patients. the number of patients tested and the number of patients with a positiv ... | 2012 | 23015670 |
| [whipple's disease--a rare and severe systemic infection]. | whipple's disease is a very rare systemic infection caused by the bacterium tropheryma whipplei. if untreated it can be fatal. approximately one thousand infections caused by this microorganism have been reported globally. our two patients with whipple's disease suffered from weight loss, diarrhea and abdominal pain and distention, and were diagnosed with microcytic anemia and significant hypoalbuminemia. in the third patient the manifestation was blood culture negative endocarditis causing aort ... | 2012 | 23025154 |
| whipple's disease. | whipple's disease is a chronic multisystemic infection, due to tropheryma whipplei, a bacterium ubiquitously present in the environment. although it is very rare, its clinical features are non-specific and can affect several different districts. whipple's disease is therefore a condition that should always be kept in mind by doctors working in several branches of medicine, such as internal medicine, gastroenterology, rheumatology, neurology, and cardiology. the condition is fatal if not promptly ... | 2012 | 23073859 |
| tropheryma whipplei aortic valve endocarditis, cured without surgical treatment. | culture-negative endocarditis due to tropheryma whipplei is a rare disease. mostly the diagnosis is made by histologic examination of resected heart valve tissue. | 2012 | 23110725 |
| the role of molecular diagnostics in implant-associated bone and joint infection. | microbiological culture is the conventional method for establishing the diagnosis in implant-associated bone and joint infection, but it may lack both specificity and sensitivity. molecular diagnosis has been an important step in the diagnosis of infectious diseases. we review the principles and the role of molecular diagnosis in improving the aetiological diagnosis of implant-associated bone and joint infection. currently, molecular diagnosis mainly includes conventional broad-range pcr and spe ... | 2012 | 23148447 |
| [role of infectious agents in the emergence of malignant tumors]. | according to the data of the international agency for research on cancer (iarc), at least 6 virus species (hpv, ebv, hhv-8/kshv, htlv-1, hbv, hcv), 4 helminthes species (schistosoma haematobium and japonicum, opisthorchis viverrini, clonorchis sinensis) and i bacterium species (helicobacter pylori) have been proved to be capable of causing the development of cancer. the analysis of the data available shows that merkel cell polyomavirus (mcv), herpes simplex virus (hsv), john cunningham polyomavi ... | 2012 | 23163048 |
| axenic culture of fastidious and intracellular bacteria. | the culture of microorganisms has been the basis of microbiology. however, revolutionary tools such as metagenomics have made it possible to describe uncultivated bacteria, but several breakthroughs have occurred in culture leading to a revival of these techniques. in this review we focus on new applications that have successfully cultivated previously uncultivated bacteria. we also review the axenic cultivation of intracellular bacteria such as tropheryma whipplei and coxiella burnetii. these s ... | 2013 | 23182864 |
| looking for tropheryma whipplei source and reservoir in rural senegal. | tropheryma whipplei, the bacterium linked to whipple's disease, is involved in acute infections and asymptomatic carriage. in rural senegal, the prevalence of t. whipplei is generally high but is not homogeneous throughout households in the same village. we studied environmental samples collected in two senegalese villages and conducted the survey to investigate the difference between households. overall, the comparison between five households with very high t. whipplei prevalence and three hous ... | 2012 | 23249690 |
| tropheryma whipplei as a commensal bacterium. | tropheryma whipplei is the bacterial agent of the well-known and rare whipple's disease, mainly observed among caucasians. this bacterium has recently been involved in other chronic and acute infections. for a long time, the only known source of the bacterium was patients with whipple's disease; however, thanks to the advent of molecular biology, t. whipplei has now been detected in specimens from healthy individuals, mainly in stool and saliva samples. the prevalence of carriage depends on seve ... | 2013 | 23252493 |
| intravenous ceftriaxone, followed by 12 or three months of oral treatment with trimethoprim-sulfamethoxazole in whipple's disease. | there is no agreement on how and for how long whipple's disease should be treated. in a randomized trial it was shown that patients can be cured with ceftriaxone or meropenem followed by trimethoprim-sulfamethoxazole for 12 months. the present study tested whether trimethoprim-sulfamethoxazole for three months is sufficient. | 2013 | 23291038 |
| whipple's disease. | whipple's disease is a chronic, systemic infection caused by tropheryma whipplei. gene amplification, isolation and dna sequencing of t whipplei have extended our knowledge of this pathogen, which is now recognised as a ubiquitous commensal bacterium. the spectrum of signs associated with t whipplei has now been extended beyond the classic form, which affects middle-aged men, and begins with recurrent arthritis followed several years later by digestive problems associated with other diverse clin ... | 2013 | 23291386 |
| first pillcam colon 2 capsule images of whipple's disease: case report and review of the literature. | whipple's disease is a rare chronic systemic infection determined by the gram-positive bacillus tropheryma whipplei. the infection usually mainly involves the small bowel, but sometimes other organs are affected as well. since the current standard clinical and biological tests are nonspecific, diagnosis is very difficult and relies on histopathology. here we present the case of a 52-year-old man with chronic diarrhea and weight loss whose symptoms had been evolving for 2 years and whose diagnosi ... | 2012 | 23293729 |
| two-step bacterial broad-range polymerase chain reaction analysis of heart valve tissue improves bacteriological diagnosis of infective endocarditis. | positive heart valve (hv) culture is a major duke's criterion for the diagnosis of infective endocarditis but is poorly sensitive. two broad-range 16s rdna polymerase chain reaction (pcr) methods were applied to 31 hv samples: first, a real-time method, then conventional end-point pcr was applied to hv samples on which the first pcr was negative. five specific real-time pcr procedures were also used in order to identify bartonella spp., tropheryma whipplei, chlamydophila pneumoniae, mycoplasma p ... | 2013 | 23318112 |
| whipple disease diagnosed with pcr using formalin-fixed paraffin-embedded specimens of the intestinal mucosa. | we herein present the case of a 54-year-old japanese woman with whipple disease diagnosed with polymerase chain reaction (pcr) using formalin-fixed paraffin-embedded (ffpe) specimens. the patient complained of weight loss, diarrhea and arthralgia. an endoscopic examination revealed swollen villi in the duodenum and ileum. pathology demonstrated the presence of numerous macrophages filled with diastase-resistant pas-positive particles. pcr using ffpe specimens amplified a fragment of 16s rdna fro ... | 2013 | 23318851 |
| resolution of whipple disease-induced pulmonary hypertension following antibiotic therapy. | whipple disease is a disorder caused by tropheryma whipplei, a ubiquitous gram-positive bacillus. in addition to gastrointestinal manifestations, many other systems may be involved in whipple disease. pulmonary hypertension (ph) is a rare manifestation of whipple disease, and its clinical course is not well established. we report a case of a 45-year-old woman who presented with typical gastrointestinal manifestations of whipple disease, which was diagnosed by duodenal biopsy. she was also noted ... | 2014 | 23344104 |
| tropheryma whipplei genotypes 1 and 3, central europe. | 2013 | 23347594 | |
| point-of-care laboratory of pathogen diagnosis in rural senegal. | in tropical africa, where the spectrum of the bacterial pathogens that cause fevers is poorly understood and molecular-based diagnostic laboratories are rare, the time lag between test results and patient care is a critical point for treatment of disease. | 2013 | 23350001 |
| immunopathology of immune reconstitution inflammatory syndrome in whipple's disease. | during antimicrobial treatment of classic whipple's disease (cwd), the chronic systemic infection with tropheryma whipplei, immune reconstitution inflammatory syndrome (iris), is a serious complication. the aim of our study was to characterize the immunological processes underlying iris in cwd. following the definition of iris, we describe histological features of iris and immunological parameters of 24 cwd iris patients, 189 cwd patients without iris, and 89 healthy individuals. t cell reconsti ... | 2013 | 23365082 |
| widespread colonization of the lung by tropheryma whipplei in hiv infection. | lung infections caused by opportunistic or virulent pathogens are a principal cause of morbidity and mortality in hiv infection. it is unknown whether hiv infection leads to changes in basal lung microflora, which may contribute to chronic pulmonary complications that increasingly are being recognized in individuals infected with hiv. | 2013 | 23392441 |
| tropheryma whipplei endocarditis relapses after treatment with trimethoprim/sulfamethoxazole. | 2013 | 23507410 | |
| pcr-electrospray ionization mass spectrometry for direct detection of pathogens and antimicrobial resistance from heart valves in patients with infective endocarditis. | microbiological diagnosis is pivotal to the appropriate management and treatment of infective endocarditis. we evaluated pcr-electrospray ionization mass spectrometry (pcr/esi-ms) for bacterial and candidal detection using 83 formalin-fixed paraffin-embedded heart valves from subjects with endocarditis who had positive valve and/or blood cultures, 63 of whom had positive valvular gram stains. pcr/esi-ms yielded 55% positivity with concordant microbiology at the genus/species or organism group le ... | 2013 | 23596241 |
| whipple's disease. | this article reviews the microbiology, pathophysiology, epidemiology, clinical manifestations, diagnostic testing, and treatment of whipple's disease, an illness caused by tropheryma whipplei and characterized by multivariate clinical manifestations including an inflammatory arthropathy. diagnosis is confirmed by tissue sampling with periodic acid-schiff staining and/or polymerase chain reaction. clinical manifestations most frequently manifest in the gastrointestinal tract, musculoskeletal syst ... | 2013 | 23597966 |
| [undiagnosed whipple's disease with a lethal outcome]. | whipples disease is a rare multisystem disease caused by rod-shaped bacteria tropheryma whipplei. although it affects all age groups, the typical patient is a middle-aged white man. the clinical signs are very heterogeneous and depend on the stage of the disease. the most common is abdominal manifestation characterized by weight loss, disability, chronic diarrhea and abdominal pain. untreated whipples disease is almost always fatal. we describe probably the first published case of undiagnosed wh ... | 2013 | 23641716 |
| whipple's disease infection surgical treatment: presentation of a rare case and literature review. | the whipple' disease (w.d.) is a very rare disease with an incidence of 1 per 1.000.000 inhabitants; it is a systemic infection that may mimic a wide spectrum of clinical disorders, which may have a fatal outcome and affects mainly male 40-50 years old. the infective agent is an actinomycete, tropheryma whipplei (t.w.) that was isolated 100 years after first description by wipple, and identified in macrophages of mucosa of the small intestine by biopsy which is characterized by periodic acid-sch ... | 2013 | 23660163 |
| [a rare cause of recurrent monarthritis of the knee]. | isolated monarthritis caused by tropheryma whipplei without involvement of the gastrointestinal tract is rare but is nowadays often described as an early manifestation of the disease. in a male patient with recurrent knee joint arthritis for several years, we could ultimately diagnose whipple's disease based on pcr positive biopsies of synovial tissue and fluid. furthermore, the patient was found to be an asymptomatic t. whipplei carrier. with adequate antibiotic therapy the patient has meanwhil ... | 2013 | 23685853 |
| cell extract-containing medium for culture of intracellular fastidious bacteria. | the culture of fastidious microorganisms is a critical step in infectious disease studies. as a proof-of-concept experiment, we evaluated an empirical medium containing eukaryotic cell extracts for its ability to support the growth of coxiella burnetii. here, we demonstrate the exponential growth of several bacterial strains, including the c. burnetii nine mile phase i and phase ii strains, and c. burnetii isolates from humans and animals. low-oxygen-tension conditions and the presence of small ... | 2013 | 23740722 |
| whipple's disease with gastrointestinal involvement and multiple abdominal adenopathies. | 2013 | 23755972 | |
| [tropheryma whipplei endocarditis]. | whipple's disease is a rare infectious disease caused by the bacterium tropheryma whipplei. usually the course of the disease is characterized by fever, diarrhea, weight loss and polyarthritis. we report on a case with a 10-year course of the disease with endocarditis, myocarditis and involvement of the bone marrow but with negative histological results of the small intestine. | 2014 | 23807487 |
| whipple's disease: our own experience and review of the literature. | whipple's disease is a chronic infectious systemic disease caused by the bacterium tropheryma whipplei. nondeforming arthritis is frequently an initial complaint. gastrointestinal and general symptoms include marked diarrhoea (with serious malabsorption), abdominal pain, prominent weight loss, and low-grade fever. possible neurologic symptoms (up to 20%) might be associated with worse prognosis. diagnosis is based on the clinical picture and small intestinal histology revealing foamy macrophages ... | 2013 | 23843784 |
| [drug therapy of infectious diarrhea. part 2: chronic diarrhea]. | diarrheal diseases are among the most common diseases worldwide. in this review the current treatment recommendations for acute (part 1) and chronic (part 2) infectious diarrhea are summarized and typical enteropathogens are discussed. the second part of the article describes chronic diarrhea, its related pathogens and treatment. in contrast to acute diarrhea which is mainly caused by viral and typical bacterial pathogens, chronic diarrhea has mainly non-infectious origins. protozoal pathogens, ... | 2013 | 23917963 |
| [duodenal biopsy is the most important examination when diagnosing whipple's disease]. | whipple's disease is a rare disease caused by the bacteria tropheryma whipplei. it can present with different disease patterns including arthritis, gastrointestinal symptoms with abdominal pain and diarrhoea, malnutrition, anaemia and neurological symptoms. we present a case of a 71-year-old man who underwent a six-month long, thorough investigation before reaching the right diagnosis. after sufficient treatment the symptoms remitted. physicians should be vigilant of this differential diagnosis ... | 2013 | 23937876 |
| treatment of classic whipple's disease: from in vitro results to clinical outcome. | patients with classic whipple's disease have a lifetime defect in immunity to tropheryma whipplei and frequently develop treatment failures, relapses or reinfections. empirical treatments were tested before culture was possible, but the only in vitro bactericidal treatment consists of a combination of doxycycline and hydroxychloroquine. | 2014 | 23946319 |
| validation of an rpob gene pcr assay for detection of tropheryma whipplei: 10 years' experience in a national reference laboratory. | the performance of a real-time pcr assay targeting the tropheryma whipplei rpob gene was evaluated using test strains and 1,236 clinical specimens in a national reference laboratory. the novel rpob-pcr assay proved to be specific, revealed improved analytical sensitivity, and substantially accelerated detection of t. whipplei dna in clinical specimens. | 2013 | 23966507 |
| [weight loss, dementia and ataxia susceptible to doxycycline: a likely new case report caused by t. whipplei]. | whipple's disease is a rare infectious disease due to tropheryma whipplei, a bacterium rarely causing severe localized neurological infection (only 25 cases reported in the literature), which are more often diagnosed by a positive t. whipplei pcr performed on cerebrospinal fluid. | 2013 | 24075626 |
| tropheryma whipplei pneumonia in a patient with hiv-2 infection. | 2013 | 24127807 | |
| whipple's disease. | whipple's disease is a chronic, systemic infection caused by tropheryma whipplei. gene amplification, isolation and dna sequencing of t whipplei have extended our knowledge of this pathogen, which is now recognised as a ubiquitous commensal bacterium. the spectrum of signs associated with t whipplei has now been extended beyond the classic form, which affects middle-aged men, and begins with recurrent arthritis followed several years later by digestive problems associated with other diverse clin ... | 2013 | 24129033 |
| central nervous system involvement in whipple disease: clinical study of 18 patients and long-term follow-up. | whipple disease (wd) is a rare multisystemic infection with a protean clinical presentation. the central nervous system (cns) is involved in 3 situations: cns involvement in classic wd, cns relapse in previously treated wd, and isolated cns infection. we retrospectively analyzed clinical features, diagnostic workup, brain imaging, cerebrospinal fluid (csf) study, treatment, and follow-up data in 18 patients with wd and cns infection. ten men and 8 women were included with a median age at diagnos ... | 2013 | 24145700 |
| rheumatic and musculoskeletal features of whipple disease: a report of 29 cases. | whipple disease is a rare infection caused by tropheryma whipplei. although patients commonly complain of osteoarticular involvement, musculoskeletal manifestations have been poorly described. we report cases of whipple disease with rheumatic symptoms and describe their clinical presentation, modes of diagnosis, and outcomes. | 2013 | 24187107 |
| tropheryma whipplei endocarditis. | tropheryma whipplei endocarditis differs from classic whipple disease, which primarily affects the gastrointestinal system. we diagnosed 28 cases of t. whipplei endocarditis in marseille, france, and compared them with cases reported in the literature. specimens were analyzed mostly by molecular and histologic techniques. duke criteria were ineffective for diagnosis before heart valve analysis. the disease occurred in men 40-80 years of age, of whom 21 (75%) had arthralgia (75%); 9 (32%) had val ... | 2013 | 24207100 |
| constrictive pleuropericarditis: a dominant clinical manifestation in whipple's disease. | whipple's disease is a rare, multisystemic, chronic infectious disease which classically presents as a wasting illness characterized by polyarthralgia, diarrhea, fever, and lymphadenopathy. pleuropericardial involvement is a common pathologic finding in patients with whipple's disease, but rarely causes clinical symptoms. we report the first case of severe fibrosing pleuropericarditis necessitating pleural decortication in a patient with whipple's disease. | 2013 | 24321135 |
| whipple's in the valleys: a case of whipple's with thrombocytopenia and endocarditis. | this case report details the second described case of whipple's disease-related thrombocytopenia in the medical literature. whipple's disease is a rare multisystem infection caused by the actinomycete tropheryma whipplei, first described by george whipple in 1907. the key clinical manifestations are weight loss, diarrhoea and malabsorption, but arthralgia and endocarditis are also well described. | 2014 | 24459171 |
| lung microbiome for clinicians. new discoveries about bugs in healthy and diseased lungs. | microbes are readily cultured from epithelial surfaces of the skin, mouth, and colon. in the last 10 years, culture-independent dna-based techniques demonstrated that much more complex microbial communities reside on most epithelial surfaces; this includes the lower airways, where bacterial culture had failed to reliably demonstrate resident bacteria. exposure to a diverse bacterial environment is important for adequate immunological development. the most common microbes found in the lower airwa ... | 2014 | 24460444 |
| bacterial lymphadenitis at a major referral hospital in france from 2008 to 2012. | lymph node enlargement is a common medical problem, and in a large number of patients, the causes of lymphadenopathy remain undiagnosed. we report a thorough microbiological analysis of 1,688 lymph node biopsy specimens collected in our bartonellosis reference center. we studied lymph node biopsy samples from patients with suspected regional infectious lymph node enlargement from january 2008 to december 2012. to evaluate a useful strategy for the diagnosis of infectious lymphadenitis, specimens ... | 2014 | 24478415 |
| immune reconstitution inflammatory syndrome associated with bacterial infections. | immune reconstitution inflammatory syndrome (iris) is defined by various clinical manifestations following the initiation of antiretroviral treatment (art) in hiv patients primarily infected with mycobacteria. iris has clinical similarities with lepromatous reactions in patients with leprosy following antibiotic initiation. | 2014 | 24512544 |
| specific cutaneous involvement in whipple disease. | cutaneous lesions in whipple disease (wd) are infrequent, and the histological findings are usually nonspecific. specific cutaneous lesions have rarely been described and usually involve the subcutaneous fat. we report a patient diagnosed with wd, who developed multiple small subcutaneous nodules after antibiotic treatment was administered. in addition to septal panniculitis, the cutaneous biopsy showed a mild granulomatous dermal reaction with pas-positive macrophages characteristic of wd. a po ... | 2014 | 24562051 |
| tropheryma whipplei, the agent of whipple's disease, affects the early to late phagosome transition and survives in a rab5- and rab7-positive compartment. | tropheryma whipplei, the agent of whipple's disease, inhibits phago-lysosome biogenesis to create a suitable niche for its survival and replication in macrophages. to understand the mechanism by which it subverts phagosome maturation, we used biochemical and cell biological approaches to purify and characterise the intracellular compartment where tropheryma whipplei resides using mouse bone-marrow-derived macrophages. we showed that in addition to lamp-1, the tropheryma whipplei phagosome is pos ... | 2014 | 24586722 |
| tropheryma whipplei natural resistance to trimethoprim and sulphonamides in vitro. | 2014 | 24613421 | |
| does tropheryma whipplei contribute to travelers' diarrhea?: a pcr analysis of paired stool samples in french travelers to senegal. | tropheryma whipplei was recently associated with acute infections as gastroenteritis in children. we hypothesize that t. whipplei may be a contributing microbe in traveler's diarrhea. | 2015 | 24630594 |
| tumoural form of whipple's disease simulating carcinomatosis. | whipple's disease is a rare disease caused by the actinomycete bacteria tropheryma whipplei, which cause intestinal infection. the most common symptoms are chronic diarrhoea, weight loss, abdominal pain, arthritis and neurological abnormalities, which can be fatal. this paper reports a case of a 57-year-old brazilian woman with diarrhoea, vomiting, abdominal pain, appetite loss, intermittent fever, malaise, weight loss and malnutrition. migratory polyarthralgia and recurrent visual scotomas prec ... | 2014 | 24690429 |
| an unusual cause of pancytopenia: whipple's disease. | whipple's disease is a systemic infectious disease caused by the bacteria tropheryma whipplei. the most common clinical manifestations of whipple's disease are weight loss (92%), hypoalbuminemia and steatorrhea (91%, respectively), diarrhea (72%), arthralgia (67%), and abdominal pain (55%). neurological signs and symptoms from dementia to oculomasticatory myorhythmia or oculofacioskeletal myorhythmia (pathognomonic of whipple's disease), lymphadenopathy, and fatigue can also be present. pancytop ... | 2014 | 24765256 |
| occurrence of tropheryma whipplei during diarrhea in hajj pilgrims: a pcr analysis of paired rectal swabs. | tropheryma whipplei was recently associated with gastroenteritis in children. we hypothesize that t. whipplei may be a contributing microbe in traveller's diarrhea. | 2014 | 24797353 |
| tropheryma whipplei and whipple's disease. | since its identification, information concerning tropheryma whipplei, the causative agent of whipple's disease (wd), has increased. although t. whipplei is commonly infecting humans, wd is rare. the bacterium is most likely transmitted among humans via the oro-oral and the feco-oral routes. infections result in chronic conditions such as asymptomatic carriage, disseminated whipple's disease, which is usually preceded by arthralgias, and localized infections, such as endocarditis or encephalitis. ... | 2014 | 24877762 |
| whipple's disease. | whipple's disease is a rare chronic multi-systemic infection, caused by gram-positive bacillus tropheryma whipplei. the infection usually involves the small bowel, but other organs may also be involved. the diagnosis is often challenging and can only be made on histopathological examination. this report describes 2 patients presenting with abdominal pain and weight loss who finally were diagnosed to have whipple's disease. one of the patients was a renal transplant recipient. to the best of auth ... | 2014 | 24906280 |
| service evaluation to establish the sensitivity, specificity and additional value of broad-range 16s rdna pcr for the diagnosis of infective endocarditis from resected endocardial material in patients from eight uk and ireland hospitals. | infective endocarditis (ie) can be diagnosed in the clinical microbiology laboratory by culturing explanted heart valve material. we present a service evaluation that examines the sensitivity and specificity of a broad-range 16s rdna polymerase chain reaction (pcr) assay for the detection of the causative microbe in culture-proven and culture-negative cases of ie. a clinical case-note review was performed for 151 patients, from eight uk and ireland hospitals, whose endocardial specimens were ref ... | 2014 | 24930039 |
| [whipple's disease and tropheryma whipplei infections in internal medicine. when to think about it? how to treat?]. | tropheryma whipplei culture and genome sequencing have, thanks to new tools, rationalized both diagnosis and treatment of whipple's disease. whipple's disease involves mainly caucasian male, approximately 50-years-old, suffering from arthralgia, weight loss and diarrhea. a worsening of clinical manifestations after immunosuppressive therapy is frequently observed while antibiotics prescribed for another infection improves the clinical status. clinical manifestations may more rarely suggest lymph ... | 2014 | 24933290 |
| prevalence and risk factor assessment of tropheryma whipplei in a rural community in gabon: a community-based cross-sectional study. | tropheryma whipplei is the causative agent of whipple's disease and has been detected in stools of asymptomatic carriers. colonization has been associated with precarious hygienic conditions. there is a lack of knowledge about the epidemiology and transmission characteristics on a population level, so the aim of this study was to determine the overall and age-specific prevalence of t. whipplei and to identify risk factors for colonization. this molecular epidemiological survey was designed as a ... | 2014 | 24943959 |
| tropheryma whipplei endocarditis: the value of valve polymerase chain reaction in cardiac surgery. | 2014 | 24951019 | |
| isolated whipple's endocarditis: an underestimated diagnosis that requires molecular analysis of surgical material. | tropheryma whipplei is known as the bacterium that causes whipple's disease, a rare systemic illness typically affecting gastrointestinal tract, joints, and central nervous system. in addition, t whipplei infection may present as an isolated endocarditis. although previously regarded as a rare condition, t whipplei has been recognized as a major cause of culture-negative endocarditis when integrating specific molecular analysis of surgical material into the diagnostic algorithm. here, we report ... | 2014 | 24996742 |
| whipple's disease concomitant with candida esophagitis and subsequent giardia lamblia coinfection. | whipple's disease is a rare systemic condition resulting from a chronic infection by tropheryma whipplei. clinical presentation can be widely heterogeneous, often leading to delayed diagnosis and treatment. furthermore, little is known about the underlying pathogenic mechanisms, although several abnormalities in immune cell function have been observed. we describe the case of a 51-year-old woman presenting with dysphagia, odynophagia, long-lasting low-grade fever, and malabsorption syndrome who ... | 2014 | 25014626 |