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pyogenic liver abscess secondary to disseminated streptococcus anginosus from sigmoid diverticulitis.pyogenic liver abscess secondary to dissemination from sigmoid diverticulitis is rare. streptococcus anginosus has been linked to abscesses but has been rarely reported from a sigmoid diverticulitis source. we report a case of liver abscess in which the source was confounding but eventually was traced to sigmoid diverticulitis on laparotomy.201121572613
the role of bacteria in oral cancer.despite the widening interest in the possible association between bacteria and different stages of cancer development, our knowledge in its relation to oral cancers remains inadequate. the aim of this review article is to derive a better understanding on the role of various micro-organisms in the etiogenesis of oral cancers through all the available data on the pubmed. different bacteria have been proposed to induce carcinogenesis either through induction of chronic inflammation or by interferen ...201021584217
experimental alveolitis in rats: microbiological, acute phase response and histometric characterization of delayed alveolar healing.the pathogenesis of alveolitis is not well known and therefore experimental situations that mimic some features of this disease should be developed.201121625744
congenital alterations of nemo glutamic acid 223 result in hypohidrotic ectodermal dysplasia and immunodeficiency with normal serum igg levels.hypomorphic mutations in the nuclear factor-+¦b (nf-+¦b) essential modulator (nemo) gene result in a variable syndrome of somatic and immunologic abnormalities. clinically relevant genotype-phenotype associations are essential to understanding this complex disease.201121704885
high-level fluorescence labeling of gram-positive pathogens.fluorescence labeling of bacterial pathogens has a broad range of interesting applications including the observation of living bacteria within host cells. we constructed a novel vector based on the e. coli streptococcal shuttle plasmid pat28 that can propagate in numerous bacterial species from different genera. the plasmid harbors a promoterless copy of the green fluorescent variant gene egfp under the control of the camp-factor gene (cfb) promoter of streptococcus agalactiae and was designated ...201121731607
splenic abscess and multiple brain abscesses caused by streptococcus intermedius in a young healthy man.we report a case of splenic abscess with multiple brain abscesses caused by streptococcus intermedius in a healthy young man without any identifiable risk factors, which resolved with percutaneous drainage and antibiotics. streptococcus intermedius, a member of the streptococcus anginosus group, is a common commensal organism of the oral cavity and gastrointestinal tract, and it is a known cause of deep-seated infections. suppurative infections caused by streptococcus anginosus group are sometim ...201121738290
concurrent postpartum uterine and abdominal wall dehiscence and streptococcus anginosus infection.: postpartum uterine scar dehiscence is a rare but potentially lethal complication of cesarean deliveries.201121768850
antibiotic effects on bacterial profile in osteonecrosis of the jaw.oral diseases (2011) 18, 85-95 objective:  oral infection is considered to play a critical role in the pathogenesis of bisphosphonate-related osteonecrosis of the jaw (bronj), and antibiotic therapy has become a mainstay of bronj therapy. this study was aimed to investigate the effect of antibiotics on bacterial diversity in bronj tissues. materials and methods:  the bacterial profile from soft tissues associated with the bronj lesion was determined using 16s rrna-based denaturing gradient gel e ...201221883710
[analysis of predominant bacterial species and clinical backgrounds in lung abscess patients].we reviewed the clinicopathological characteristics of lung abscesses retrospectively. we analyzed 89 patients hospitalized from july 1984 to may 2009. most were men (76/89). there were large proportions with alcohol consumption (29.2%) and dental caries or gingivitis (60.7%). furthermore, those without other diseases accounted for only 13.5%. predominant infectious species were clear in 43 cases (48.3%) including identification of bacteria. the identification rate of predominant bacteria improv ...201122073605
man with shoulder pain after a fall. necrotizing fasciitis. 201122098998
organization of the capsule biosynthesis gene locus of the oral streptococcus streptococcus anginosus.the capsular polysaccharide (cps) of the important oral streptococcus streptococcus anginosus, which causes endocarditis, and the genes for its synthesis have not been clarified. in this study, we investigated the gene locus required for cps synthesis in s. anginosus. southern hybridization using the cpse gene of the well-characterized bacterium s. agalactiae revealed that there is a similar gene in the genome of s. anginosus. by using the colony hybridization technique and inverse pcr, we isola ...201122100898
[Abscess in the spleen in a 28 year-old, previously healthy man].A 28 year-old, previously healthy man was hospitalised with acute abdominal pain and a high fever. During six months the patient had suffered from severe pain in his left shoulder, left part of the thorax and over time also in the upper part of the abdomen. When hospitalised he showed biochemical signs of infection and a computer tomography of the abdomen revealed an 11 cm abscess in the spleen. Non-haemolytic streptococci were found after aspiration. Initially the abscess was treated with antib ...201122118655
intrathecal granuloma and intramedullary abscess associated with an intrathecal morphine pump.objective and importance. several previous reports have documented cord compression resulting from the formation of an intrathecal inflammatory mass in patients using intrathecal drug delivery systems. we present the first reported case of an intramedullary abscess and intrathecal inflammatory mass associated with an intrathecal drug delivery system. clinical presentation. a 47-year-old man was transferred to our institution from an outside hospital with a 3-week history of the inability to am ...200722151806
brain abscess in the computed tomography era: a 10-year experience from auckland, new zealand.notes were reviewed for 68 patients with brain abscess diagnosed at auckland hospital, auckland, new zealand between 1978 and 1988. mean age was 30 years (range one week to 74 years). there were 48 men and 40% were maori or pacific island polynesians. seventy-two per cent of patients had headache, 54% had fever and 72% had lateralizing neurological signs. thirty-one per cent of abscesses were associated with contiguous infection (otic, sinus, dental). forty-four per cent were in the frontal lobe ...199322346451
microbiological analysis of a prospective, randomized, double-blind trial comparing moxifloxacin and clindamycin in the treatment of odontogenic infiltrates and abscesses.the objective of this study was to identify the oral pathogens found in odontogenic infections, to determine their susceptibilities to amoxicillin-clavulanic acid (amc), clindamycin (cli), doxycycline (dox), levofloxacin (lvx), moxifloxacin (mxf), and penicillin (pen), and to search for associations between specific pathogens and types of infection. swabs from patients enrolled in a randomized, double-blind phase ii trial comparing mxf with cli for the treatment of odontogenic abscesses or infla ...201222354306
milleri group streptococcus--a stepchild in the viridans family.the purpose of this investigation was to provide a comprehensive review of the pathogenic role and spectrum of disease of milleri group streptococci, with special attention to bloodstream invasion and to possible differential roles among the three species. all consecutive isolates of milleri group streptococci from any anatomic source, during a 37-month period, in a tertiary care teaching hospital in tel-aviv, israel, were thoroughly investigated. identification to the species level was performe ...201222391759
endogenous endophthalmitis and liver abscesses.we present a case of endogenous endophthalmitis secondary to liver abscesses, in a patient with no previous medical comorbidities or risk factors for immunosuppression. the patient presented with acute painless loss of vision and feeling generally unwell. investigations revealed streptococcus anginosus-constellatus bacteraemia, and evidence of diverticular disease that likely predisposed to the liver abscesses. due to prompt diagnosis and administration of antibiotics, the patient had a good vis ...201222423344
[analysis of diversity of vaginal microbiota in healthy chinese women by using dna-fingerprinting].to analyze the diversity of healthy women's vaginal dominant flora in different physiological states with pcr-denaturing gradient gel electrophoresis (pcr-dgge), to establish the basis for the future study of lower genital tract infections, and to provide a theoretical basis for the development of vaginal probiotics adapted to chinese females.201222517004
prevalence of β-hemolytic groups c and f streptococci in patients with acute pharyngitis.the roles of group c and f streptococci in causing endemic pharyngitis are still controversial, although group c streptococci are implicated in the outbreaks of pharyngitis and associated disorders.201122540078
pantoea agglomerans in immunodeficient patients with different respiratory symptoms.the aim of this paper was to determine in 32 patients from 4 different mexican hospitals the frequency of opportunistic bacteria in the 2010 to 2011 time period. the patients were divided in 4 groups. group 1 included 21 hiv positive patients with acute respiratory syndrome. four hiv positive patients with tuberculosis symptoms were included in group 2; two patients with tuberculosis symptoms and one asymptomatic person formed group 3. reference group 4 included 4 patients from whom 4 strains of ...201222619600
ascending necrotizing fasciitis of the face following odontogenic infection.necrotizing fasciitis (nf) of the face is a rare but extremely dangerous complication of dental infection associated with a nearly 30% mortality rate. this infection spreads rapidly along the superficial fascial planes of the head and neck and can lead to severe disfigurement. reports in the literature of cases of nf of the face caused by dental infection are few. we report such a case in a 36-year-old woman and review the current standards of diagnosis and management. the patient initially pres ...201222627436
structural insights into catalysis by βc-s lyase from streptococcus anginosus.hydrogen sulfide (h(2)s) is a causative agent of oral malodor and may play an important role in the pathogenicity of oral bacteria such as streptococcus anginosus. in this microorganism, h(2)s production is associated with βc-s lyase (lcd) encoded by lcd gene, which is a pyridoxal 5'-phosphate (plp)-dependent enzyme that catalyzes the α,β-elimination of sulfur-containing amino acids. when lcd acts on l-cysteine, h(2)s is produced along with pyruvate and ammonia. to understand the h(2)s-producing ...201222674431
[problems with identification of beta-hemolytic streptococcus resistant to bacitracin isolated from patients with pharyngitis].the genus streptococcus comprises a number of species characterized by a differential pathogenic potential. these bacteria can be considered as members of microbial physiological flora but they can also cause mild infections or severe, life threatening conditions. the majority of infections of streptococcal etiology are caused by beta-hemolysing species. the predominant causative agent of bacterial pharyngitis is streptococcus pyogenes. this species usually doesn't give rise to any identificatio ...201222808724
real-time monitoring of the adherence of streptococcus anginosus group bacteria to extracellular matrix decorin and biglycan proteoglycans in biofilm formation.members of the streptococcus anginosus group (sags) are significant pathogens. however, their pathogenic mechanisms are incompletely understood. this study investigates the adherence of sags to the matrix proteoglycans decorin and biglycan of soft gingival and alveolar bone. recombinant chondroitin 4-sulphate(c4s)-conjugated decorin and biglycan were synthesised using mammalian expression systems. c4s-conjugated decorin/biglycan and dermatan sulphate (ds) decorin/biglycan were isolated from ovin ...201222835945
neurological picture. multiple intracranial abscesses due to streptococcus anginosus in a previously well individual. 201222851610
pediatric focal intracranial suppuration: a uk single-center experience.brain abscess (ba) and subdural empyema (sde) are uncommon but clinically important conditions in childhood. treatment involves surgery and prolonged courses of antibiotics. there is no consensus on the optimal approach. the objective was to review management and outcome of ba and sde in a single uk center.201222864509
uv-c-irradiation sublethal stress does not alter antibiotic susceptibility of the viridans group streptococci to β-lactam, macrolide, and fluoroquinolone antibiotic agents.previous work has indicated that environmental stresses on bacteria might lead to an upregulation of stress response. led curing lights (315-400 nm) and other uv lights used in tooth whitening cosmetic procedures might act as stresses. we examined the effect of uv-c light, as a high-energy surrogate to the lower-energy uv-a light used in such instruments, to examine its effect on the antibiotic susceptibility of viridans group streptococci.201122887906
streptococcus anginosus group disseminated infection: case report and review of literature.streptococcus anginosus group is widely known for its ability to cause invasive pyogenic infections. there are very few reports of disseminated infections sustained by members of this streptococcal group. we report a case of a highly disseminated infection and analyse previous literature reports. disseminated pyogenic infection has been defined as an infection affecting two or more of the following organs/systems: central nervous system, lung, liver and spleen. we performed a pubmed search using ...201222992554
presumed hydrogen sulfide-mediated neurotoxicity after streptococcus anginosus group meningitis.hydrogen sulfide is an environmental toxicant and gaseous neurotransmitter. it is produced enterically by sulfur-reducing bacteria and invasive pathogens including streptococcus anginosus group, salmonella and citrobacter. we describe putative focal hydrogen sulfide neurotoxicity after streptococcus constellatus meningitis, treated with adjunctive sodium nitrite and hyperbaric oxygen therapy.201323014355
antibacterial activity of various antibiotics against oral streptococci isolated in the oral cavity.a total of 550 oral streptococci: 270 streptococcus mitis, 110 streptococcus sanguis, 90 streptococcus anginosus, 50 streptococcus mutans, 30 streptococcus salivarius, were isolated from dental plaque and gengival crevices of patients and tested for their susceptibility to 12 β-lactam antibiotics and to 5 non-β-lactam antibiotics, using the microdiluition method. overall, a reduced susceptibility to penicillin was recorded in 13.4% of cases. the percentage of strains resistant to penicillin appe ...201723058035
subgingival microflora in inflammatory bowel disease patients with untreated periodontitis.to analyze the subgingival microflora composition of inflammatory bowel disease (ibd) patients with untreated chronic periodontitis and compare them with systemically healthy controls also having untreated chronic periodontitis.201323060013
microbiology and management of pediatric liver abscesses: two cases caused by streptococcus anginosus group.pyogenic liver abscesses in the pediatric population are rare occurrences in the developed world. we present two cases of previously healthy males presenting with fever and abdominal pain found to have liver abscesses due to organisms in the streptococcus anginosus group. the microbiology of s. anginosus along with the management and recommended treatment in children with liver abscesses is discussed.201223119195
taxonomy of the anginosus group of the genus streptococcus and description of streptococcus anginosus subsp. whileyi subsp. nov. and streptococcus constellatus subsp. viborgensis subsp. nov.the anginosus group of the genus streptococcus has been the subject of much taxonomic confusion, which has hampered the full appreciation of its clinical significance. the purpose of this study was to critically re-examine the taxonomy of the anginosus group, with special attention to β-haemolytic, lancefield group c strains, using multilocus sequence analysis (mlsa) combined with 16s rrna gene sequence and phenotypic analyses. phylogenetic analysis of concatenated sequences of seven housekeepin ...201323223817
development of an ex vivo coculture system to model pulpal infection by streptococcus anginosus group bacteria.streptococcus anginosus group (sag) bacteria are opportunistic pathogens and a major cause of pulpal infection and subsequent abscess formation. understanding of the processes involved in sag oral infections has been limited by the lack of an appropriate model system.201323228257
validation of a quantitative real-time pcr assay and comparison with fluorescence microscopy and selective agar plate counting for species-specific quantification of an in vitro subgingival biofilm model.subgingival biofilms are the prime etiological factor of periodontal disease. owing to their complex polymicrobial nature, quantification of individual bacterial species within the biofilm for research and diagnostic purposes can be methodologically challenging. the aims of this study were to establish a quantitative real-time pcr (qpcr) assay to quantify the bacteria used in our 10-species in vitro 'subgingival' biofilm model and to compare the quantitative outcome with fluorescence microscopy ...201223278531
novel twin streptolysin s-like peptides encoded in the sag operon homologue of beta-hemolytic streptococcus anginosus.streptococcus anginosus is a member of the anginosus group streptococci, which form part of the normal human oral flora. in contrast to the pyogenic group streptococci, our knowledge of the virulence factors of the anginosus group streptococci, including s. anginosus, is not sufficient to allow a clear understanding of the basis of their pathogenicity. generally, hemolysins are thought to be important virulence factors in streptococcal infections. in the present study, a sag operon homologue was ...201323292771
[streptococcus intermedius: a rare cause of brain abscess in children].streptococcus intermedius is a member of the streptococcus anginosus group, also known as the streptococcus milleri group. although this is a commensal agent of the mouth and upper airways, it has been recognized as an important pathogen in the formation of abscesses. however, it has rarely been involved in the formation of brain abscess in children. we report 4 pediatric cases of brain abscess caused by s. intermedius. three boys and 1 girl, all aged over 2 years, were admitted for a febrile me ...201323375710
the significance of streptococcus anginosus group in intracranial complications of pediatric rhinosinusitis.to assess the significance of the streptococcus anginosus group in intracranial complications of pediatric patients with rhinosinusitis.201323429946
two cases of bacterial suppurative thyroiditis caused by streptococcus anginosus.acute suppurative thyroiditis (ast) is a rare clinical condition. streptococcus anginosus has a propensity of producing empyema in the head and neck. here, we reported two cases of ast caused by s. anginosus. a 44-year-old man presented with anterior neck tender swelling and odynophagia for 12 days. he had thyrotoxicosis. he was initially diagnosed as thyroid cancer due to the misleading computed tomography report. fine needle aspiration (fna) yielded pus and neutrophils. s. anginosus was isolat ...201323435638
streptococcus anginosus group and osteomyelitis: a single centre clinical experience.the streptococcus anginosus group comprises three species of bacteria classified within the viridans streptococci. this group is known for abscess formation and endocarditis. while a variety of sites in the body claim anginosus streptococci as an agent of infection, osteomyelitis is unusual. the objective of this study was to describe a series of patients with osteomyelitis due to s anginosus group pathogens in terms of demographics, comorbidities, presentation and outcomes.201323515349
a silent acute abdomen in a patient with spinal cord injury.a 52-year-old man with cervical spondylosis sustained a hyperextension injury to the neck and subsequently developed central cord syndrome after 2 weeks. the diagnosis was confirmed clinically and on mri. during the admission he was febrile from streptococcus anginosus bacteraemia from a gum infection and was started on penicillin. this resulted in pseudomembranous colitis with abdominal distension and bloody diarrhoea but a lack of expected abdominal complaints. unfortunately his neurology dete ...201323536647
identification of β-haemolysin-encoding genes in streptococcus anginosus.streptococcus anginosus is an emerging pathogen, but little is known about its virulence factors. to detect the genes responsible for β-haemolysis we performed genomic mutagenesis of the β-haemolytic s. anginosus type strain atcc 12395 using the vector pghost9:iss1. integration site analysis of 15 non-haemolytic mutants identified a gene cluster with high homology to the genes of the streptolysin s (sls) encoding sag gene cluster of s. pyogenes. the gene cluster harbours 10 open reading frames d ...201323594064
identification, clinical aspects, susceptibility pattern, and molecular epidemiology of beta-haemolytic group g streptococcus anginosus group isolates from central taiwan.no literature is available on the prevalence and clinical aspects of beta-haemolytic group g streptococcus anginosus group in central taiwan. in this study, we used 16s rrna gene sequencing and 16s-23s rdna intergenic spacer sequencing (where necessary) as the gold standard for molecular identification. twenty-seven s. anginosus group isolates were identified from 273 beta-haemolytic ggs isolates collected from patients in central taiwan between february 2007 and august 2011. of the 27 isolates, ...201323632249
validation of antibiotic efficacy on in vitro subgingival biofilms.systemic antibiotics are often used as adjunctive treatment modalities for periodontal diseases. testing of antimicrobial efficacy can be relevant only if the bacteria are in the form of biofilms rather than the planktonic state, and at concentrations of physiologic relevance, i.e., reachable in the periodontal pocket. the aim of the present study is to test the antimicrobial efficacy of five common antibiotic schemes at physiologically relevant concentrations on a multispecies in vitro biofilm ...201423659420
the epidemiology, antibiotic resistance and post-discharge course of peritonsillar abscesses in london, ontario.peritonsillar abscesses (pta) are a common complication of tonsillitis. recent global epidemiological data regarding ptas have demonstrated increasing antimicrobial resistance patterns. no similar studies have been conducted in canada and no canadian study has examined the post-discharge course of treated patients.201323663820
[streptococcus anginosus pancreatic abscess after dental extraction]. 201623726739
[bifrontal cerebritis and brain abscess caused by sreptococcus anginosus group: report of one case].the etiology of brain abscesses is mostly polymicrobial. streptococci and anaerobic bacteria are the most commonly isolated pathogens. we report a previously healthy female without predisposing factors, presenting with a bifrontal cerebritis caused by a streptococcus anginosus group infection. the patient developed a brain abscess and a subdural collection with severe intracranial hypertension of fatal evolution. the etiologic diagnosis was made culturing the material obtained from the subdural ...201323732422
lincosamide resistance mediated by lnu(c) (l phenotype) in a streptococcus anginosus clinical isolate.unique resistance to lincosamides (l phenotype) due to the production of nucleotidyltransferases (lnu) is uncommon among gram-positive bacteria. the aim of the study was to characterize the l phenotype in a clinical isolate of the streptococcus milleri group.201323812683
duodenal-mucosal bacteria associated with celiac disease in children.celiac disease (cd) is an immune-mediated enteropathy triggered by the ingestion of cereal gluten proteins. this disorder is associated with imbalances in the gut microbiota composition that could be involved in the pathogenesis of cd. the aim of this study was to characterize the composition and diversity of the cultivable duodenal mucosa-associated bacteria of cd patients and control children. duodenal biopsy specimens from patients with active disease on a gluten-containing diet (n = 32), pat ...201323835180
periocular necrotizing fasciitis causing blindness.periocular necrotizing fasciitis is a rare but potentially devastating disease, accompanied by high rates of morbidity and mortality.201323868053
[three cases of liver abscess associated with the streptococcus anginosus group].reports of pyogenic liver abscess (pla) caused by the streptococcus anginosus group (sag) have increased. coinfection with sag and anaerobic bacteria enhances the tendency for abscess formation. furthermore, it has been reported that sag infection results in pylethrombophlebitis as a complication. we experienced 3 cases of pla caused by sag: one case was complicated by the development of pylethrombophlebitis and the other 2 cases had coinfection with anaerobic bacteria. we report these cases tog ...201323912007
fournier's gangrene of the penis caused by streptococcus dysgalactiae subspecies equisimilis: case report and incidence study in a tertiary-care hospital.fournier's gangrene is a rare necrotizing soft tissue infection of the scrotum and penis. we report, to our knowledge, the first case of fournier's gangrene caused by streptococcus dysgalactiae subsp. equisimilis (sdse), a strain of pyogenic β-hemolytic streptococci that is increasingly being recognized as an important human pathogen.201323957431
rapid detection of gram-positive organisms by use of the verigene gram-positive blood culture nucleic acid test and the bact/alert pediatric fan system in a multicenter pediatric evaluation.assays that expedite the reporting of organism identification and antibiotic susceptibility status in positive blood cultures can fast track interventions that improve clinical outcomes. we evaluated the verigene gram-positive blood culture nucleic acid test (bc-gp) in two pediatric hospitals. positive bact/alert pediatric fan blood cultures with gram-positive organisms were tested using the bc-gp in tandem with routine laboratory procedures. to test organisms underrepresented in the clinical bl ...201323966484
tunel analysis of dna fragmentation in mouse unfertilized oocytes: the effect of microorganisms within human follicular fluid collected during ivf cycles.recently we reported the presence of bacteria within follicular fluid. previous studies have reported that dna fragmentation in human spermatozoa after in vivo or in vitro incubation with bacteria results in early embryo demise and a reduced rate of ongoing pregnancy, but the effect of bacteria on oocytes is unknown. this study examined the dna within mouse oocytes after 12 hours' incubation within human follicular fluids (n=5), which were collected from women undergoing in vitro fertilization ( ...201323972717
the predominant bacteria isolated from radicular cysts.to detect predominant bacteria associated with radicular cysts and discuss in light of the literature.201324011184
iatrogenic sinistral hypertension complicating screening colonoscopy.colonoscopy is widely accepted as the gold-standard screening technique for detecting malignancies in the distal gastrointestinal tract in patients with symptoms suggestive of colon cancer. however, this procedure is not without risk, including colonic perforation. we report a patient who was managed conservatively after colonoscopy induced perforation. eighteen months after appearing to make a full recovery, he presented with an upper gastrointestinal bleed. oesophago-gastro-duodenoscopy (ogd) ...201324024063
evaluation of the nanosphere verigene gram-positive blood culture assay with the versatrek blood culture system and assessment of possible impact on selected patients.the verigene gram-positive blood culture (bc-gp) assay (nanosphere, northbrook, il) is a molecular method for the rapid identification of gram-positive organisms and resistance markers directly from blood culture bottles. a total of 148 versatrek redox 1 40-ml aerobic bottles demonstrating gram-positive bacteria were tested. results were compared with those from conventional biochemical and matrix-assisted laser desorption ionization-time of flight (maldi-tof) identifications. we obtained isolat ...201324048531
microarray analysis of microbiota of gingival lesions in noma patients.noma (cancrum oris) is a gangrenous disease of unknown etiology affecting the maxillo-facial region of young children in extremely limited resource countries. in an attempt to better understand the microbiological events occurring during this disease, we used phylogenetic and low-density microarrays targeting the 16s rrna gene to characterize the gingival flora of acute noma and acute necrotizing gingivitis (ang) lesions, and compared them to healthy control subjects of the same geographical and ...201324086784
fatal streptococcus anginosus-associated pneumonia in a captive sumatran orangutan (pongo abelii).bacterial infections commonly affect the lungs and air sacs of orangutans; culture and identification is rarely performed and may have clinical relevance.201424117447
invasive streptococcus anginosus group infection-does the species predict the outcome?to determine whether there is an association between the species of streptococcus anginosus group (sag) bacteria and the clinical outcome.201424215937
oral status in patients with early rheumatoid arthritis: a prospective, case-control study.patients with ra suffer from a higher risk of periodontal attachment loss and increased oral inflammation. we hypothesize that there are pathogenetic and immunological interactions between these diseases that go beyond impaired manual dexterity accompanying advanced ra. the primary objective of the present study was to determine whether a loss of alveolar bone can be detected in ra patients during the early course of the disease.201424273047
streptococcus anginosus, tooth extraction and brain abscess. 201424334300
impact of early colonizers on in vitro subgingival biofilm formation.the aim of this study was to investigate the impact of early colonizing species on the structure and the composition of the bacterial community developing in a subgingival 10-species biofilm model system. the model included streptococcus oralis, streptococcus anginosus, actinomycesoris, fusobacterium nucleatum subsp. nucleatum, veillonella dispar, campylobacter rectus, prevotella intermedia, porphyromonas gingivalis, tannerella forsythia, and treponema denticola. based on literature, we consider ...201324340084
phylogenetic relationship and virulence inference of streptococcus anginosus group: curated annotation and whole-genome comparative analysis support distinct species designation.the streptococcus anginosus group (sag) represents three closely related species of the viridans group streptococci recognized as commensal bacteria of the oral, gastrointestinal and urogenital tracts. the sag also cause severe invasive infections, and are pathogens during cystic fibrosis (cf) pulmonary exacerbation. little genomic information or description of virulence mechanisms is currently available for sag. we conducted intra and inter species whole-genome comparative analyses with 59 publ ...201324341328
dental abscess: a microbiological review.dental abscess is a frequently occurring infectious process known to the health practice. the fate of the infection depends on the virulence of the bacteria, host resistance factors, and regional anatomy. serious consequences arising from the spread of a dental abscess lead to significant morbidity and mortality. acute dental abscess is polymicrobial, comprising of strict anaerobes, such as anaerobic cocci, prevotella, fusobacterium species, and facultative anaerobes, such as viridans group stre ...201324348613
descending necrotizing mediastinitis: a modified algorithmic approach to define a new standard of care.descending necrotizing mediastinitis (dnm) is a highly morbid infectious process. this uncommon disease process has carried historically a substantial burden of morbidity and mortality. in this study we hypothesized that application of a prospective modified management algorithm would decrease the morbidity and mortality from this highly destructive process.201324351133
pneumonia and empyema caused by streptococcus intermedius that shows the diagnostic importance of evaluating the microbiota in the lower respiratory tract.the bacterial species in the streptococcus anginosus group (s. constellatus, s. anginosus, s. intermedius) are important causative pathogens of bacterial pneumonia, pulmonary abscesses and empyema. however, the bacteria in this group are primarily oral resident bacteria and unable to grow significantly on ordinary aerobic culture media. we experienced a case of pneumonia and empyema caused by streptococcus intermedius detected using a 16s rrna gene sequencing analysis of bronchoalveolar lavage f ...201424390528
streptococcus anginosus pyogenic liver abscess following a screening colonoscopy.a previously healthy 58-year-old man presented with a septic thrombosis of the right hepatic vein and a pyogenic liver abscess (pla) one week after undergoing a screening colonoscopy. blood cultures and a radiological drainage specimen were both positive for streptococcus anginosus. evolution was favourable after six weeks of antibiotherapy. to the authors' knowledge, the present report is the first to describe a pla following a screening colonoscopy with no intervention. the authors hypothesize ...201324421818
role of bacteria in oral carcinogenesis.oral cancer is the most common cancer diagnosed in indian men and is the leading cause of cancer deaths. it is considered as a multistep and multifactorial disease. besides accumulation of genetic mutations, numerous other carcinogens are involved. in this category, viral and chemical carcinogens are well studied and documented. however, in the oral cavity, the role of microbiota in carcinogenesis is not known. microbial populations on mouth mucosa differ between healthy and malignant sites, and ...201224455519
stent hypersensitivity and infection in sinus cavities.persistent mucosal inflammation, granulation tissue formation, hypersensitivity, and multifactorial infection are newly described complications of retained drug-eluting stents from endoscopic sinus surgery for refractory rhinosinusitis. in an important report published in allergy and rhinology, a 45-year-old male patient suffering from recalcitrant chronic rhinosinusitis underwent functional endoscopic sinus surgery and was found, for the first time, to have steroid-eluting catheters that were i ...201324498522
a streptolysin s homologue is essential for β-haemolytic streptococcus constellatus subsp. constellatus cytotoxicity.streptococcus constellatus is a member of the anginosus group streptococci (ags) and primarily inhabits the human oral cavity. s. constellatus is composed of three subspecies: s. constellatus subsp. constellatus (scc), s. constellatus subsp. pharyngis and the newly described subspecies s. constellatus subsp. viborgensis. although previous studies have established that scc contains β-haemolytic strains, the factor(s) responsible for β-haemolysis in β-haemolytic scc (β-scc) has yet to be clarified ...201424600025
an unusual case of streptococcus anginosus group pyomyositis diagnosed using direct 16s ribosomal dna sequencing.bacteria belonging to the streptococcus anginosus group (streptococcus intermedius, streptococcus constellatus and streptococcus anginosus) are capable of causing serious pyogenic infections, with a tendency for abscess formation. the present article reports a case of s anginosus group pyomyositis in a 47-year-old man. the pathogen was recovered from one of two blood cultures obtained from the patient, but speciation was initially not performed because the organism was considered to be a contami ...201424634686
bacterial profile of dentine caries and the impact of ph on bacterial population diversity.dental caries is caused by the release of organic acids from fermentative bacteria, which results in the dissolution of hydroxyapatite matrices of enamel and dentine. while low environmental ph is proposed to cause a shift in the consortium of oral bacteria, favouring the development of caries, the impact of this variable has been overlooked in microbial population studies. this study aimed to detail the zonal composition of the microbiota associated with carious dentine lesions with reference t ...201424675997
64-year-old male with septic arthritis of the pubic symphysis.septic arthritis of the pubic symphysis is a rare disease. typical clinical features include fever, pubic or groin pain, pain with hip motion, and painful or waddling gait. identified predisposing factors to develop an infection in pubic joint include female incontinence surgery or postpartum period; sports, especially soccer; pelvic malignancy; and intravenous drug abuse. the most often identified microorganisms were staphylococcus aureus and pseudomonas aeruginosa. osteomyelitis complicates th ...201124765337
antibiotic susceptibilities, streptococcal pyrogenic exotoxin gene profiles among clinical isolates of group c or g streptococcus dysgalactiae subsp. equisimilis & of group g s. anginosus group at a tertiary care centre.group c and group g streptococci (together gcgs) are often regarded as commensal bacteria and their role in streptococcal disease burden is under-recognized. while reports of recovery of gcgs from normally sterile body sites are increasing, their resistance to macrolides, fluoroquinolone further warrants all invasive β haemolytic streptococci to be identified to the species level and accurately tested for antimicrobial susceptibility. this study was aimed to determine the prevalence, clinical pr ...201424820839
molecular pathogenicity of streptococcus anginosus.streptococcus anginosus and the closely related species streptococcus constellatus and streptococcus intermedius, are primarily commensals of the mucosa. the true pathogenic potential of this group has been under-recognized for a long time because of difficulties in correct species identification as well as the commensal nature of these species. in recent years, streptococci of the s. anginosus group have been increasingly found as relevant microbial pathogens in abscesses and blood cultures and ...201424848553
the potential role of lung microbiota in lung cancer attributed to household coal burning exposures.bacteria influence site-specific disease etiology and the host's ability to metabolize xenobiotics, such as polycyclic aromatic hydrocarbons (pahs). lung cancer in xuanwei, china has been attributed to pah-rich household air pollution from burning coal. this study seeks to explore the role of lung microbiota in lung cancer among never smoking xuanwei women and how coal burning may influence these associations. dna from sputum and buccal samples of never smoking lung cancer cases (n = 8, in dupli ...201424895247
identification of the 'streptococcus anginosus group' by matrix-assisted laser desorption ionization--time-of-flight mass spectrometry.matrix-assisted laser desorption/ionization time-of-flight mass spectrometry (maldi-tof ms) provides rapid, accurate and cost-effective identification of a range of bacteria and is rapidly changing the face of routine diagnostic microbiology. however, certain groups of bacteria, for example streptococci (in particular viridans or non-haemolytic streptococci), are less reliably identified by this method. we studied the performance of maldi-tof ms for identification of the 'streptococcus anginosus ...201424917618
cavernosal abscess due to streptococcus anginosus: a case report and comprehensive review of the literature.corpus cavernosum abscesses are uncommon with only 23 prior reports in the literature. several precipitating factors for cavernosal infections have been described including injection therapy for erectile dysfunction, trauma, and priapism. common causal organisms include staphylococcus aureus, streptococci, and bacteroides. we report a unique case of a corpus cavernosum abscess due to proctitis with hematological seeding and review the literature on cavernosal abscesses.201324917758
development of species-specific quantitative real-time pcr primers for detecting anginosus group streptococci based on the rpob.in this study, we introduced species-specific quantitative real-time pcr (qpcr) primers designed based on a dna-dependent rna polymerase beta-subunit gene for detecting anginosus group streptococci (ags), streptococcus anginosus, s. constellatus, and s. intermedius. the specificity of the qpcr primers was confirmed by conventional pcr with the genomic dnas of 76 strains regarding 44 bacterial species including the type strain for the target species. the standard curves revealed the lower detecti ...201424942606
colonisation of gingival epithelia by subgingival biofilms in vitro: role of "red complex" bacteria.biofilm formation on tooth surface results in colonisation and invasion of the juxtaposed gingival tissue, eliciting strong inflammatory responses that lead to periodontal disease. this in vitro study investigated the colonisation of human gingival multi-layered epithelium by multi-species subgingival biofilms, and evaluated the relative effects of the "red complex" species (porphyromonas gingivalis, tannerella forsythia and treponema denticola).201424949828
vang element insertions within a conserved chromosomal site conferring vancomycin resistance to streptococcus agalactiae and streptococcus anginosus.three vancomycin-resistant streptococcal strains carrying vang elements (two invasive streptococcus agalactiae isolates [gbs-ny and gbs-nm, both serotype ii and multilocus sequence type 22] and one streptococcus anginosus [sa]) were examined. the 45,585-bp elements found within sa and gbs-ny were nearly identical (together designated vang-1) and shared near-identity over an ~15-kb overlap with a previously described vang element from enterococcus faecalis. unexpectedly, vang-1 shared much less h ...201425053786
molecular analysis of streptococcus anginosus-derived saga peptides.saga1 and saga2 molecules produced from beta-hemolytic streptococcus anginosus subsp. anginosus are composed of a leader peptide and a propeptide, and their mature form has hemolytic activity as a well-known streptococcal peptide toxin, streptolysin. the function of these saga molecules is thought to be dependent on intra-molecular heterocycle formation. in this study, we examined the heterocycle-involved molecular features of saga1, saga2, and s. pyogenes saga (spysaga), focusing on their heter ...201425075110
competence for genetic transformation in streptococcus pneumoniae: mutations in σa bypass the comw requirement.competence for genetic transformation in the genus streptococcus depends on an alternative sigma factor, σ(x), for coordinated synthesis of 23 proteins, which together establish the x state by permitting lysis of incompetent streptococci, uptake of dna fragments, and integration of strands of that dna into the resident genome. initiation of transient accumulation of high levels of σ(x) is coordinated between cells by transcription factors linked to peptide pheromone signals. in streptococcus pne ...201425112479
neurological picture. multiple intracranial arteritis and hypothyroidism secondary to streptococcus anginosus infection. 201525143631
chromosomal islands of streptococcus pyogenes and related streptococci: molecular switches for survival and virulence.streptococcus pyogenes is a significant pathogen of humans, annually causing over 700,000,000 infections and 500,000 deaths. virulence in s. pyogenes is closely linked to mobile genetic elements like phages and chromosomal islands (ci). s. pyogenes phage-like chromosomal islands (spyci) confer a complex mutator phenotype on their host. spyci integrate into the 5' end of dna mismatch repair (mmr) gene mutl, which also disrupts downstream operon genes lmrp, ruva, and tag. during early logarithmic ...201425161960
streptococcus intermedius bacteremia and liver abscess following a routine dental cleaning.streptococcus intermedius is a member of the streptococcus anginosus group of bacteria. this group is part of the normal flora of the oropharynx, genitourinary, and gastrointestinal tracts; however, they have been known to cause a variety of purulent infections including meningitis, endocarditis, and abscesses, even in immunocompetent hosts. in particular, s. intermedius has been associated with the development of liver and brain abscesses. there have been several case reports of s. intermedius ...201425197585
secondary aortoduodenal fistula following endovascular repair of inflammatory abdominal aortic aneurysm due to streptococcus anginosus infection: a case report and literature review.aortoenteric fistula is a rare but very serious complication of both surgical and endovascular abdominal aortic reconstruction. since the advent of endovascular abdominal aortic aneurysm repair (evar), 20 cases of aortoduodenal fistula associated with aortic stent grafts have been reported.(1) however, only a handful has been reported following inflammatory abdominal aortic aneurysm repair. it most commonly presents with bleeding, usually from the upper gastro-intestinal tract. with recent advan ...201425201477
streptococcus anginosus infections: crossing tissue planes.streptococcus anginosus has long been recognized to cause invasive pyogenic infections. this holds true for thoracic infections where s. anginosus has a propensity for abscess and empyema formation. early diagnosis is important given the significant morbidity and mortality associated with thoracic s. anginosus infections. yet, distinguishing thoracic s. anginosus clinically is difficult. we present three cases of thoracic s. anginosus that demonstrated radiographic extension across tissue planes ...201425288003
activity of oritavancin against gram-positive clinical isolates responsible for documented skin and soft-tissue infections in european and us hospitals (2010-13).to assess oritavancin activity in vitro against clinically relevant gram-positive pathogens causing skin and soft-tissue infections (sstis) in european and us hospitals.201525362568
antimicrobial activity of preparation bioaron c.the antimicrobial activity of sirupus bioaron c, a preparation, whose main ingredient is an extract from the leaves of aloe arborescens, was tested against different microorganisms isolated from patients with upper respiratory tract infections. the experiments were performed on 40 strains: 20 strains of anaerobic bacteria, 13 strains of aerobic bacteria and 7 strains of yeast-like fungi from the genus candida and on 18 reference strains (atcc). the antimicrobial activity of bioaron c (mbc and mf ...201425362808
streptolysin s of streptococcus anginosus exhibits broad-range hemolytic activity.streptococcus anginosus is a commensal of mucous membranes and an emerging human pathogen. some strains, including the type strain, display a prominent β-hemolytic phenotype. a gene cluster (sag), encoding a variant of streptolysin s (sls) has recently been identified as the genetic background for β-hemolysin production in s. anginosus. in this study, we further characterized the hemolytic and cytolytic activity of the s. anginosus hemolysin in comparison with other streptococcal hemolysins. the ...201525381594
oral bacterial dna findings in pericardial fluid.we recently reported that large amounts of oral bacterial dna can be found in thrombus aspirates of myocardial infarction patients. some case reports describe bacterial findings in pericardial fluid, mostly done with conventional culturing and a few with pcr; in purulent pericarditis, nevertheless, bacterial pcr has not been used as a diagnostic method before.201425412607
subperiosteal abscess of the orbit: evolving pathogens and the therapeutic protocol.because of widespread antibiotic use, immunization against selective species, and the emergence of hypervirulent organisms, we sought to determine changes over time in the bacteriology of sinusitis-related subperiosteal abscess (spa) of the orbit and their impact on patient outcomes under a uniform management protocol.201525439602
simultaneous bilateral decortications via video-assisted thoracic surgery for bilateral empyema.bilateral empyema is a rare and life-threatening condition that is difficult to treat. we herein report a case of bilateral empyema that was treated with simultaneous bilateral decortications via video-assisted thoracic surgery (vats).201525528031
[bacteria isolated from surgical infections and its susceptibilities to antimicrobial agents--special references to bacteria isolated between april 2010 and march 2011].bacteria isolated from surgical infections during the period from april 2010 to march 2011 were investigated in a multicenter study in japan, and the following results were obtained. in this series, 631 strains including 25 strains of candida spp. were isolated from 170 (81.7%) of 208 patients with surgical infections. four hundred and twenty two strains were isolated from primary infections, and 184 strains were isolated from surgical site infection. from primary infections, anaerobic gram-nega ...201425549405
establishment of an oral infection model resembling the periodontal pocket in a perfusion bioreactor system.periodontal infection involves a complex interplay between oral biofilms, gingival tissues and cells of the immune system in a dynamic microenvironment. a humanized in vitro model that reduces the need for experimental animal models, while recapitulating key biological events in a periodontal pocket, would constitute a technical advancement in the study of periodontal disease. the aim of this study was to use a dynamic perfusion bioreactor in order to develop a gingival epithelial-fibroblast-mon ...201525587671
ventricular septal defect and bivalvular endocarditis.a 63-year-old man presented with generalized fatigue, chills, malaise, dyspnea, intermittent fevers, and 50-pound weight loss of 4 months' duration. blood cultures were positive for pan-sensitive streptococcus anginosus. transesophageal echocardiography showed an 11 mm × 3 mm mobile mass attached to the mitral valve, a 16 mm × 16 mm mobile mass attached to the pulmonary valve, and a small membranous ventricular septal defect. the patient received 12 weeks of intravenous (iv) antibiotics with eve ...201725625086
surrogate analysis of vancomycin to predict susceptible categorization of dalbavancin.dalbavancin (dal) represents a recently approved addition for the treatment of acute bacterial skin and skin structure infections (absssis). newly released antimicrobial agents are rarely found on commercial susceptibility testing devices, and surrogate testing may be an option for clinical microbiology laboratories. a total of 33,688 staphylococcus aureus, 2800 viridans group streptococci (vgs), and 5722 β-hemolytic streptococci (bhs) were included in this cross-susceptibility (dal versus vanco ...201525724854
quantification of pseudomonas aeruginosa in multispecies biofilms using pma-qpcr.multispecies biofilms are an important healthcare problem and may lead to persistent infections. these infections are difficult to treat, as cells in a biofilm are highly resistant to antimicrobial agents. while increasingly being recognized as important, the properties of multispecies biofilms remain poorly studied. in order to do so, the quantification of the individual species is needed. the current cultivation-based approaches can lead to an underestimation of the actual cell number and are ...201525755923
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