Publications

comparative therapeutic efficacy of teicoplanin and vancomycin in normal and in neutropenic mice infected with staphylococcus haemolyticus.	this study describes the evaluation of a murine bacteraemia model for assessing antibiotic efficacy in normal and neutropenic mice infected with coagulase-negative staphylococci. in one such evaluation, it was found that there was no significant (p greater than 0.05) difference in the ability of teicoplanin or vancomycin to protect normal or neutropenic cd-1 mice, lethally-infected with staphylococcus haemolyticus. however, about a four-fold increase of either antibiotic was needed to protect th ...	1991	1838105
[community epidemiology].		2007	1853100
[generalities on the immunological mechanisms of graft rejection].		2007	1853117
presence and localization of a 30-kda basic fibroblast growth factor-like protein in rodent testes.	we have used a recently characterized rabbit antiserum against basic fibroblast growth factor (bfgf), which recognizes various forms of bfgf, to examine the presence and localization of bfgf in the testes of adult rats and mice and the 5-day-old rat. in western blots of testicular homogenates of adult rats and mice and immature rats, immunoreactive single bands at approximately 30 kda were detected. immunocytochemistry revealed specific staining restricted to the tubular compartment. in 5-day-ol ...	1991	1855483
body mass index variations: centiles from birth to 87 years.	this report provides body mass index (weight/height2) values for the french population from birth to the age of 87 years. bmi curves increase during the first year, decrease until the age of 6, increase again up to 65 years and decrease thereafter. these variations reflect the total changes of fat body mass during life. the 50th centile values of wt/ht2 at the ages of 20, 40, 60, 80 years are 21.5, 24.6, 25.4, 24.4 kg/m2 for men and 20.6, 22.6, 24.1, 23.4 kg/m2 for women. the values for the 3rd, ...	2007	1855495
optimal conditions for long-term photoreceptor cell rescue in rcs rats: the necessity for healthy rpe transplants.	retinal pigment epithelial (rpe) cells from normal long-evans, healthy royal college of surgeons (rcs) pigmented congenic (rdy+p+) and rcs pigmented dystrophic rats were transplanted into retinas of rcs non-pigmented dystrophic rats at post-natal days 17 and 26 (p17 and p26). when examined at p60, rescued photoreceptor cells were found in all transplanted groups. in addition, a small, but significant increase in the outer nuclear layer (onl) thickness was detected in retinas injected with vehicl ...	1991	1855542
a qualitative approach to cell growth modeling and simulation for cancer chemotherapy.	a qualitative model of cell growth, based on qualitative process theory, is presented. the model can be used to analyze the effects of the interaction of antiproliferative drugs on cells when the effects of each specific drug are known, mainly when designing multi-drug protocols for optimal cancer treatment.	2007	1855803
endogenous n-nitrosation and cancer of the biliary tract.	evidence is presented that n-nitroso compounds occur in bile from patients who have undergone surgery for gallstones or had gastrectomy and from unoperated persons. it is unlikely, therefore, that local formation of nitrosamines can account for the excess risk for gallbladder cancer in the first two groups. gastric formation remains the likeliest hypothesis.	2007	1855836
bacterial formation of n-nitroso compounds in the rat stomach after omeprazole-induced achlorhydria.	n-nitrosamine formation by bacteria in the achlorhydric stomach has been proposed as an important factor in the development of gastric cancer. thus, the effect of the presence of bacteria in the stomach on endogenous nitrosation was investigated in rats given omeprazole (an inhibitor of gastric h+, k((+)-atpase) which reduces gastric secretion sufficiently to allow survival of a bacterial suspension of escherichia coli or pseudomonas. when rats were given both thiazolidine 4-carboxylic acid and ...	1991	1855848
some 'sort of vascular phenomenon'.		2006	1867603
infectious crystalline keratopathy caused by candida albicans.	two patients developed corneal opacities resembling infectious crystalline keratopathy. predisposing factors included a recent corneal transplant with suture replacement in one patient and postradiation keratoconjunctivitis with disposable therapeutic contact-lens wear in the other patient. both patients were using a topically applied corticosteroid and an aminoglycoside antimicrobial. smears of corneal scrapings showed numerous yeasts without inflammatory cells. culturing yielded candida albica ...	1991	1882943
adjuvant chemotherapy of high-grade osteosarcoma of the extremity. updated results of the multi-institutional osteosarcoma study.	the multi-institutional osteosarcoma study (mios) was designed to determine whether intensive multiagent adjuvant chemotherapy improves the outcome of patients with nonmetastatic high-grade osteosarcoma of the extremity as compared with concurrent controls. after definitive surgery of the primary tumor, patients were randomly assigned to immediate adjuvant chemotherapy or to observation without adjuvant treatment. updated results of this trial indicate that the projected six-year event-free surv ...	2004	1884563
antimicrobial activity of cefpirome. an update compared to five third-generation cephalosporins against nearly 6000 recent clinical isolates from five medical centers.	cefpirome, cefotaxime, ceftazidime, cefoperazone, ceftizoxime, and ceftriaxone were tested against approximately 6000 fresh clinical isolates from five medical centers. for 3031 strains of enterobacteriaceae tested, cefpirome consistently had the lowest mic50s and lowest percentage of resistant strains. cefpirome was also the most active agent against the 2138 gram-positive cocci tested; staphylococcus haemolyticus was uniformly resistant to all agents tested. against 791 nonenteric gram-negativ ...	1991	1889187
relative quantification of collagen mrna in fibroblasts by a radioactive polymerase chain reaction technique.	a radioactive polymerase chain reaction (pcr) method has been developed for the relative quantification of the human alpha-2 chain of type i collagen [hu alpha-2(i)] in cells. cdnas generated by reverse transcription from the total pool of cytoplasmic rna serve as a template for polymerase chain reaction amplification of a hu alpha-2(i) cdna primed by two sequence-specific synthetic oligonucleotides. the distinctive 390 bp hu alpha-2(i) cdna and two aval fragments of 220 and 170 bp are identifie ...	1991	1890540
identification of regulatory properties of metabolic networks by graph theoretical modeling.	an earlier graph theoretical model of metabolic and gene-expression networks has been modified and extended to include the effect of electrical potentials on binding constants, representation of uncatalyzed processes, and treatment of parallel reactions catalyzed by a single enzyme. formal operations on the graph, which are facilitated by a set of standardized guidelines, identify the feedback signals in the network and rank them according to their influence. the technique was applied to a model ...	2007	1890846
submicromolar manganese dependence of golgi vesicular galactosyltransferase (lactose synthetase).	1. manganese(ii) buffers were set up with inorganic triphosphate, trimethylenediaminetetraacetate and tetramethylenediaminetetraacetate to study the mn dependence of beta 1,4-galactosyltransferase (lactose synthetase) in preparations of rat mammary gland. 2. in intact particulate preparations, treated with the calcium ionophore a23187, lactose synthesis was abolished by chelators and restored by bivalent transition metal ions in a manner characteristic of activation site i of the pure enzyme. ni ...	1991	1899383
new prosthetic venous collar anastomotic technique: combining the best of other procedures.		2007	1913097
expanded polytetrafluoroethylene patch in hernia repair: a review of clinical experience.	the use of an implantable prosthetic material is often needed to repair inguinal and incisional hernias, especially when the local tissue is of poor quality or there is a large defect that would cause excessive tension if closed without patching with prosthetic material. an expanded polytetrafluoroethylene (eptfe) patch was used in 37 patients between may 1986 and may 1990 to repair 25 direct inguinal and 12 incisional hernias. there was one recurrence in the group of patients with incisional he ...	2007	1913399
molecular cloning, purification, and properties of a plasmid-encoded chloramphenicol acetyltransferase from staphylococcus haemolyticus.	a small chloramphenicol resistance (cmr) plasmid of approximately 3.75 kb, designated pscs5, was isolated from staphylococcus haemolyticus. this plasmid encoded an inducible chloramphenicol acetyltransferase (cat; ec 2.3.1.28). the cat gene of pscs5 was cloned into the escherichia coli plasmid vector pbluescript skii+. it differed in its nucleotide sequence and deduced amino acid sequence from the cat genes described previously in staphylococci and other gram-positive bacteria. the cat enzyme wa ...	1991	1929282
nucleotide sequence and phylogeny of a chloramphenicol acetyltransferase encoded by the plasmid pscs7 from staphylococcus aureus.	the nucleotide sequence of the chloramphenicol acetyltransferase gene (cat) and its regulatory region, encoded by the plasmid pscs7 from staphylococcus aureus, was determined. the structural cat gene encoded a protein of 209 amino acids, which represented one monomer of the enzyme chloramphenicol acetyltransferase (cat). comparisons between the amino acid sequences of the pscs7-encoded cat from s. aureus and the previously sequenced cat variants from s. aureus, staphylococcus intermedius, staphy ...	1991	1929326
general practice as a career.		2007	1932976
effects of induced elated and depressed mood on self-focused attention.	recent accounts of depression propose a central role for increased self-focus in the onset and maintenance of depression. the present study investigated whether there might also be a converse effect of depressed mood increasing self-focus. a state measure of self-focused attention was administered to normal subjects before and after induction of depressed or happy mood. compared to happy subjects, depressed subjects showed more negative and less positive self-focus. positive and negative externa ...	2007	1933048
definitions of disc disease.		2007	1933095
enhanced healing of 30 microns gore-tex ptfe microarterial prostheses by alcohol-pretreatment.	polytetrafluoroethylene (ptfe) microvascular prostheses with a fibril length of 30 microns were pretreated with alcohol (n = 18), implanted into the abdominal aorta of rats and were evaluated at 1 day (n = 3), 1 week (n = 3), 3 weeks (n = 6) and 6 weeks (n = 6) to determine whether alcohol-pretreatment might improve their healing. untreated ptfe microvascular prostheses (n = 18) functioned as controls (all prostheses: length 10 mm, i.d. 1.5 mm). the alcohol-pretreated ptfe microarterial prosthes ...	1991	1933114
identification of methicillin-resistant strains of staphylococci by polymerase chain reaction.	a simple and reliable method using a polymerase chain reaction (pcr) was devised to identify methicillin-resistant staphylococci. by using lysates of the strain to be tested as templates and 22-mer oligonucleotides as primers, a 533-bp region of meca, the structural gene of a low-affinity penicillin-binding protein (pbp 2'), was amplified by pcr and detected by agarose gel electrophoresis. results obtained by this method were compared with those obtained by broth microdilution mic determination ...	1991	1939577
modifying attitudes toward persons with hearing impairments. a comprehensive review of the research.	negative attitudes toward persons with hearing impairments adversely affect their opportunities and self-concepts. thus, modifying such attitudes is of concern to educators and researchers. an exhaustive search of the literature yielded 12 reports of research on modifying attitudes toward persons with hearing impairments. the research results were mixed--some studies even yielded negative attitude outcomes--and the quality of the studies was not high. of the treatments studied, properly structur ...	2007	1950947
neither heparin nor acetylsalicylic acid influence the clinical course in human plasmodium falciparum malaria: a prospective randomized study.	procoagulant alterations and thrombocytopenia in falciparum malaria correlate with parasitemia, serum levels of tumor necrosis factor alpha (tnf alpha), and clinical severity. thus, heparin or acetylsalicylic acid (asa), which are used frequently to prevent thrombosis and (in the case of asa) to control fever, could be potentially beneficial. we randomized 97 patients with falciparum malaria into three groups: 33 patients received low-dose heparin subcutaneously, 31 received asa intravenously, a ...	1991	1951871
the effect of prophylaxis with chloroquine and proguanil on delayed-type hypersensitivity and antibody production following vaccination with diphtheria, tetanus, polio, and pneumococcal vaccines.	in vitro studies have shown that anti-malarial drugs suppress immunity. in this study, the effects of chloroquine and proguanil (paludrine) on the cellular and humoral immune system were measured by two in vivo methods: 1) cell-mediated immunity (delayed cutaneous hypersensitivity) i.e., skin tests with seven delayed-type common antigens (multitest) and 2) humoral immunity by measurement of specific antibody response to vaccination. sixty healthy young individuals were randomized into four group ...	1991	1951872
evaluation of restriction endonuclease fingerprinting of chromosomal dna and plasmid profile analysis for characterization of multiresistant coagulase-negative staphylococci in bacteremic neonates.	a procedure was developed for restriction endonuclease fingerprinting (ref) of the chromosomal dna of coagulase-negative staphylococci. a total of 48 isolates comprising 29 staphylococcus epidermidis and 19 staphylococcus haemolyticus isolates from blood and mucocutaneous sites of 15 premature neonates were characterized by ref, plasmid profile (pp) analysis, antimicrobial susceptibility testing, biotyping, and slime production. on the basis of ref analysis of chromosomal dna, the 48 coagulase-n ...	1990	1968906
evaluation of the staph-zym system with staphylococci isolated from bovine intramammary infections.	a total of 148 staphylococci isolated from bovine intramammary infections were used to evaluate the staph-zym system (rosco, taastrup, denmark). the overall accuracy of the system was 91.9%. the system correctly identified all strains of staphylococcus aureus, staphylococcus simulans, and staphylococcus xylosus and 95% of staphylococcus intermedius strains. of 33 staphylococcus hyicus strains, 31 (93.9%) were classified correctly by the staph-zym system, as well as 8 (80%) of 10 staphylococcus c ...	1991	1993769
cost consciousness.		2007	1995750
epidemiology of campylobacter enteritis.	campylobacter enteritis is the commonest form of infective diarrhoea in most developed countries of the world. in england and wales laboratory reports indicate an annual incidence of about 85/100,000, but the true rate is probably nearer 1100/100,000. measured costs run to many millions of pounds per year. most infections are sporadic and believed to be foodborne; large outbreaks are infrequent and mostly due to the consumption of raw milk or unchlorinated water. raw meats and animal products, n ...	1991	2018709
occurrence of staphylococcus lugdunensis in consecutive clinical cultures and relationship of isolation to infection.	consecutive record review over a 63-month period revealed 229 staphylococcus lugdunensis isolates, or 10.1% of the staphylococcal species that were not staphylococcus aureus or staphylococcus epidermidis. a total of 155 s. lugdunensis specimens were isolated from sites over the entire bodies of the 143 patients studied. the most common clinical diagnoses were skin and skin structure infections (55.4%) and blood and vascular catheter infections (17.4%). for 40% of the reviewed specimens, s. lugdu ...	1991	2037657
flumazenil therapy in benzodiazepine self-poisoning.		2007	2045270
a convenient method for differentiation of coagulase-negative staphylococci isolated from bovine mammary glands.	the utility of trehalose-mannitol broth and arabinose-cellobiose broth for identification of staphylococcus epidermidis and novobiocin-resistant staphylococci was determined using 236 coagulase-negative staphylococci isolated from bovine mammary glands. none of the 49 s. epidermidis strains was positive in trehalose-mannitol broth; whereas, all strains of staphylococcus hyicus, staphylococcus chromogenes, staphylococcus haemolyticus, staphylococcus hominis, staphylococcus warneri, and staphyloco ...	1991	2045549
insulin degradation in vivo: a high-performance liquid chromatographic analysis.	the metabolism of insulin in vivo was investigated using an isocratic reversed-phase high-performance liquid chromatographic (rp-hplc) method. after intravenous injection of a14-[125i]insulin into normals, eight labelled insulin derivatives were found in plasma (peaks 1-8). two of them (peaks 1 and 7) showed an elution pattern identical with those of reference [125i]monoiodotyrosine and intact a14-[125i]insulin, respectively. of the other six peaks, five (2-6) eluted before and one (peak 8) afte ...	2004	2094722
fracture strength of class i versus class ii restored premolars tested at the marginal ridge. 2. cavosurface bonding and cavosurface plus internal enamel bonding.	the purpose of this study was to test the difference between the strength of the marginal ridge of extracted teeth with a class i composite resin restoration and the strength of the marginal ridge of teeth with a class ii amalgam restoration with retention grooves. a statistically significant difference in fracture strengths was found among groups. no statistically significant difference was found among restored preparations, beveling technique, and restorative material. statistically significan ...	2002	2094870
basal ganglia-thalamocortical circuits: parallel substrates for motor, oculomotor, "prefrontal" and "limbic" functions.	the central theme of the "segregated circuits" hypothesis is that structural convergence and functional integration occurs within, rather than between, each of the identified circuits. admittedly, the anatomical evidence upon which this scheme is based remains incomplete. the hypothesis continues to be predicated largely on comparisons of anterograde and retrograde labeling studies carried out in different sets of animals. only in the case of the "motor" circuit has evidence for the continuity o ...	2002	2094891
comparative study of hemolytic substances produced by coagulase-negative staphylococcus strains.	hemolytic substances h7, h62, and e56, produced by staphylococcus haemolyticus 7 and 62 and s. epidermidis 56, respectively, were purified. h7 and h62 are probably similar on the basis of their isoelectric focusing profiles in 8 m urea and complete immunological identity as revealed by immunodiffusion with rabbit anti-h7 and anti-e56 sera. for e56, we observed seven bands instead of three in isoelectric focusing and only partial immunological identity with h7 and h62. however, h7 and e56 were si ...	1990	2114358
[successful resection of mediastinal and abdominal recurrent tumors of esophageal leiomyosarcoma 12 years after surgery].	a 57-year-old woman admitted to our hospital in october, 1988 because of the tumor of the abdominal wall and abnormal shadows of right chest wall and right upper mediastinum. her esophagus had been resected and reconstructed by the stomach roll because of the esophageal leiomyosarcoma in may, 1976. clinical examinations revealed that the abdominal mass and chest shadows were the recurrence of the leiomyosarcoma. the abdominal tumor was resected on 17th october, 1988. on 14th december, 1988 right ...	2007	2137887
failure of teicoplanin therapy in two neutropenic patients with staphylococcal septicemia who recovered after administration of vancomycin.	a report is given on two neutropenic patients with staphylococcal septicemia caused by staphylococcus haemolyticus and staphylococcus aureus (both strains methicillin-resistant) who failed to respond to therapy with teicoplanin. both strains were resistant to teicoplanin (mic 16 and 8 mg/l respectively), but remained sensitive to vancomycin (mic 2 and 4 mg/l respectively). replacement of teicoplanin with vancomycin led to full recovery of both patients and their discharge from hospital. these tw ...	1990	2138543
selection of vancomycin- and teicoplanin-resistant staphylococcus haemolyticus during teicoplanin treatment of s. epidermidis infection.		1990	2140112
phage-typing of coagulase-negative staphylococci. factors influencing typability.	factors influencing the phage-typability of coagulase-negative micrococcaceae have been studied in 2,778 clinical isolates comprising a) 209 consecutive isolates from one laboratory, b) 2,107 clinical strains submitted for phage-typing for epidemiological reasons, and c) 462 strains representing all isolates of presumed clinical significance found in two laboratories during one month. the reproducibility was acceptable at duplicate repeated typing of the same strains as well as by typing epidemi ...	1990	2141261
[the use of teicoplanin in neutropenic patients: values and limits].	the efficacy and the safety of teicoplanin were evaluated for the treatment of febrile episodes in neutropenic patients. a total of 18 patients received teicoplanin once daily as an intravenous injection of 200 mg in 6 patients (after a loading dose of 400 mg) or 400 mg in 12 patients (loading dose: 800 mg). the mean duration of therapy was 15.9 days (range 9 to 39 days). in all patients teicoplanin was combined with another antibiotic usually a beta-lactam. thirteen of 18 patients were successf ...	1990	2143573
in vitro activity of ly264826, a new glycopeptide antibiotic, against gram-positive bacteria isolated from patients with cancer.	the in vitro activity of ly264826, a novel glycopeptide antibiotic produced by amycolatopsis orientalis, was compared with those of vancomycin, teicoplanin, and oxacillin against 311 gram-positive clinical isolates from patients with cancer, ly264826 had lower mics for 90% of isolates (mic90) than vancomycin for all species tested. it was active against oxacillin-resistant isolates including staphylococcus aureus (mic90, 0.5 micrograms/ml), staphylococcus haemolyticus (mic90, 2.0 micrograms/ml), ...	1990	2149921
sulfation of tyrosine residues in coagulation factor v.	sulfation of human coagulation factor v was investigated by biosynthetically labeling the products of hepg2 cells with [35s]sulfate. there was abundant incorporation of the sulfate label into a product identified as factor v by immunoprecipitation, lability to proteases, affinity for the lectin jacalin, and sodium dodecyl sulfate-polyacrylamide gel electrophoresis. two or more sites in factor v incorporated sulfate as indicated by labeling of different peptide chains of factor va. the 150-kd act ...	1990	2168225
[stimulation methods of reflexotherapy in the treatment of vertebrogenic lumbosacral pain syndromes (a review)].		2007	2168618
[osmotic homeostasis and blood rheology in patients in the acute period of ischemic cerebral infarction].	the authors describe the role of changes in osmotic homeostasis and hemorheology in the pathogenesis of ischemic brain stroke. 48 patients experiencing an acute period of ischemic brain stroke were examined. for this purpose the following methods were employed: measurements of blood, urine and csf osmolality by knauer osmometer; glucose and urea by the enzymatic assay; blood electrolytes by flame photometer; aggregation of platelets, red blood cells, blood viscosity, fibrinogen, hematocrit; the ...	2007	2175076
collagens synthesized by healing fractures.	several extracellular matrices are formed by healing fractures, and the collagens within these matrices have been identified in rabbit and rat fracture models. type iii collagen is the major collagen of the fibrous matrix that forms along the periosteal surface. type i collagen is secreted in large amounts as trabeculae of bone develop within the fibrous tissue. type v collagen is found in both the fibrous tissue and bone; it is particularly associated with blood vessels. type ii collagen is the ...	1990	2189630
ventilatory management of ards: can it affect the outcome?	animal studies have demonstrated that mechanical ventilation with high peak inspiratory pressure (pip) results in acute lung injury characterised by hyaline membranes, granulocyte infiltration and increased pulmonary and systemic vascular permeability. this can result in progressive respiratory failure and death. in surfactant deficient lungs this occurs with tidal volumes (vt) as low as 12 ml/kg, and pip as low as 25 cm h2o, values which are frequently used clinically. the mechanisms resulting ...	1990	2193041
a method to determine the end point of decalcification of hard tissue and bone.	a method for decalcification end point determination of mineralized tissue is described. the calcium content of the decalcification solution was determined colorimetrically with a "continuous automatic analyzer" with a high degree of accuracy. the end point method used has been tested on two decalcification methods, 5% nitric acid with or without ultrasonic treatment. the results suggest it is possible to quantitate the decalcification process.	2001	2193429
[complete denture with liquid cushion].		2008	2203631
alpha-thalassemia: prenatal diagnosis and neonatal implications.	homozygous alpha-thalassemia major, or bart's hemoglobinopathy, is the most common etiology of nonimmune hydrops in those of oriental descent. the prenatal diagnosis can now be made utilizing dna hybridization technique from fetal cells obtained by either amniocentesis or chorionic villus sampling. a case is reviewed documenting the utilization of dna studies in managing patients known or suspected to have a history of alpha-thalassemia major.	2007	2222628
characterization of the cdna coding for mouse prothrombin and localization of the gene on mouse chromosome 2.	a series of overlapping cdnas coding for mouse prothrombin (coagulation factor ii) have been isolated and the composite dna sequence has been determined. the complete prothrombin cdna is 1,987 bp in length [excluding the poly(a) tail] and codes for 18 bp of 5' untranslated sequence, an open reading frame coding for 618 amino acids, a stop codon, and a 3' untranslated region of 112 bp followed by a poly(a) tail. the translated amino acid sequence predicts a molecular weight of 66,087, which inclu ...	1990	2222810
trends in canadian tobacco consumption, 1980-89.		1990	2224718
trends in canadian tobacco consumption, 1980-89.		1990	2224718
chemotherapy-related hemolytic-uremic syndrome after the treatment of head and neck cancer. a case report.	a 62-year-old woman who was being treated for squamous cell carcinoma of the head and neck developed a chemotherapy-related hemolytic-uremic syndrome during the second cycle of neoadjuvant chemotherapy consisting of cisplatin, bleomycin, and methotrexate. though the syndrome was suspected early, attempts at reversing the hematologic and renal abnormalities were unsuccessful. at postmortem examination, the characteristic microvascular lesions of the hemolytic-uremic syndrome were found in the kid ...	2007	2224786
chemotherapy-related hemolytic-uremic syndrome after the treatment of head and neck cancer. a case report.	a 62-year-old woman who was being treated for squamous cell carcinoma of the head and neck developed a chemotherapy-related hemolytic-uremic syndrome during the second cycle of neoadjuvant chemotherapy consisting of cisplatin, bleomycin, and methotrexate. though the syndrome was suspected early, attempts at reversing the hematologic and renal abnormalities were unsuccessful. at postmortem examination, the characteristic microvascular lesions of the hemolytic-uremic syndrome were found in the kid ...	2007	2224786
comparative in vitro activity of cefpirome and cefepime, two new cephalosporins.	in in vitro tests the broad-spectrum cephalosporins cefpirome and cefepime were highly active against enterobacteriaceae, although often less so against strains resistant to amoxicillin-clavulanate and ticarcillin-clavulanate, and against most strains of acinetobacter spp. and aeromonas hydrophila. they were also active against pseudomonas aeruginosa, although strains with non-plasmid mediated beta-lactam resistance were sometimes less sensitive. other pseudomonas spp. varied in their sensitivit ...	1990	2226498
vancomycin resistance in staphylococcus haemolyticus causing colonization and bloodstream infection.	the increase in the incidence of infections due to beta-lactam-resistant coagulase-negative staphylococci has resulted in expanded use of vancomycin for such infections. despite this, coagulase-negative staphylococci have remained susceptible to vancomycin in recent years. this report describes a strain of staphylococcus haemolyticus with increased resistance to vancomycin (mic, 8.0 to 16 micrograms/ml). s. haemolyticus was initially isolated from a patient with acute leukemia and neutropenia in ...	1990	2229388
development of a malignant tumor in a liver transplant graft procured from a donor with a cerebral neoplasm.		2007	2238063
development of a malignant tumor in a liver transplant graft procured from a donor with a cerebral neoplasm.		2007	2238063
sister chromatid exchanges in the lymphocytes of tuberculosis patients receiving short-term chemotherapy.	the frequency of sister chromatid exchanges was estimated in tuberculosis patients undergoing three different short term chemotherapy regimens (2shrz, 2hrz and 2h2r2z2), to evaluate the possible genetic damage caused by anti-tuberculous drugs. of the three combinations studied, two combinations (2shrz and 2hrz), which were administered daily, enhanced the frequency of sister chromatid exchanges significantly (p less than 0.05), while the third bi-weekly combination (2h2r2z2) did not show any sig ...	2007	2238122
sister chromatid exchanges in the lymphocytes of tuberculosis patients receiving short-term chemotherapy.	the frequency of sister chromatid exchanges was estimated in tuberculosis patients undergoing three different short term chemotherapy regimens (2shrz, 2hrz and 2h2r2z2), to evaluate the possible genetic damage caused by anti-tuberculous drugs. of the three combinations studied, two combinations (2shrz and 2hrz), which were administered daily, enhanced the frequency of sister chromatid exchanges significantly (p less than 0.05), while the third bi-weekly combination (2h2r2z2) did not show any sig ...	2007	2238122
[formalized dietary advice in hypercholesterolemia. results in 110 men diagnosed by selective screening in general practice].	in connection with a screening investigation for high blood cholesterol in middle-aged men in general practice in the municipality of copenhagen, all participants with cholesterol values greater than or equal to 7.5 mmol/l were given brief advice by their own general practitioner and were invited to come for fasting blood lipid tests approximately ten days later. in cases with continued cholesterol greater than or equal to 6.8 mmol/l, the participants together with wives or partners were invited ...	2007	2238224
[formalized dietary advice in hypercholesterolemia. results in 110 men diagnosed by selective screening in general practice].	in connection with a screening investigation for high blood cholesterol in middle-aged men in general practice in the municipality of copenhagen, all participants with cholesterol values greater than or equal to 7.5 mmol/l were given brief advice by their own general practitioner and were invited to come for fasting blood lipid tests approximately ten days later. in cases with continued cholesterol greater than or equal to 6.8 mmol/l, the participants together with wives or partners were invited ...	2007	2238224
desferrioxamine provocative test: methodology for estimating iron and total iron binding capacity.		2006	2242435
neonatal monosodium glutamate abolishes corticotropin-releasing factor-induced epileptogenic activity in rats.	intracerebroventricular (i.c.v.) injection of rat corticotropin-releasing factor (rcrf) at doses of 5-20 micrograms in rats induces epileptogenic activity characterized by pacemaker-like spikes localized in the hippocampal leads. such an effect was still present in rats neonatally treated with saline but was absent in those neonatally treated with monosodium glutamate (msg), a treatment that caused marked changes in the concentration of several brain neurotransmitters and neuropeptides in hypoth ...	1990	2245800
neonatal monosodium glutamate abolishes corticotropin-releasing factor-induced epileptogenic activity in rats.	intracerebroventricular (i.c.v.) injection of rat corticotropin-releasing factor (rcrf) at doses of 5-20 micrograms in rats induces epileptogenic activity characterized by pacemaker-like spikes localized in the hippocampal leads. such an effect was still present in rats neonatally treated with saline but was absent in those neonatally treated with monosodium glutamate (msg), a treatment that caused marked changes in the concentration of several brain neurotransmitters and neuropeptides in hypoth ...	1990	2245800
[parathyroid gland].		2008	2258659
tardive eating dystonia.	after cessation of long-term treatment with haloperidol, a 77-year-old man developed severe dyskinetic-dystonic movements involving mainly the tongue and associated also with oromandibular dystonia and blepharospasm that were manifested exclusively during the process of eating and that interfered with feeding. there were no spontaneous involuntary movements nor were they apparent during any other simple or complex activations of the orofacial musculature.	1990	2259358
structural aspects of pathology in alzheimer's disease.	the characteristic lesions of alzheimer's disease, neurofibrillary tangles and neuritic plaques, are the sites of accumulation of abnormal fibrillar material. the structure of the paired helical filament from tangles has been analysed by electron microscopy and biochemical studies have shown that it contains microtubule associated protein tau as a component. fibrils of beta-amyloid in the neuritic plaque arise by polymerization of a small proteolytic fragment of a much larger precursor protein. ...	2008	2268679
[the history of the organization of museums and exhibitions of industrial hygiene and worker protection].		2008	2276671
measuring our success in meeting 1990 hypertension health objectives.		2008	2276934
presence of an additional penicillin-binding protein in methicillin-resistant staphylococcus epidermidis, staphylococcus haemolyticus, staphylococcus hominis, and staphylococcus simulans with a low affinity for methicillin, cephalothin, and cefamandole.	the presence of an additional penicillin-binding protein (pbp) was demonstrated in methicillin-resistant strains of staphylococcus epidermidis, s. haemolyticus, s. hominis, and s. simulans. in these four species, the apparent molecular mass of this protein was analogous to that of pbp 2' of methicillin-resistant s. aureus sr 1550-9. it exhibited a low affinity for methicillin, cephalothin, and cefamandole; and its synthesis was methicillin inducible. peptide mapping of this pbp from the four spe ...	1990	2285281
mathematical modeling of antimicrobial susceptibility data of staphylococcus haemolyticus for 11 antimicrobial agents, including three experimental glycopeptides and an experimental lipoglycopeptide.	antimicrobial mic data were obtained for 96 strains of staphylococcus haemolyticus and the following 11 antimicrobial agents: methicillin, gentamicin, rifampin, fusidic acid, ciprofloxacin, vancomycin, teicoplanin; three experimental glycopeptides, mdl 62,873, mdl 62,208, and mdl 62,224; and an experimental lipoglycopeptide, ramoplanin. resistance to methicillin and gentamicin was present in over 50% of the strains, although resistance to the other agents was present in less than 10%. it is show ...	1990	2285289
fulminant falciparum malaria.	a case of fulminant falciparum malaria with a 35% parasitaemia, shock and subcoma was treated successfully by using parenteral chemotherapy, exchange transfusion, dexamethasone, circulatory support and mechanical ventilation. pathophysiology and complications of falciparum malaria are discussed. the treatment of severe malaria should aim for a fast reduction in parasitaemia and toxic products. an exchange transfusion can be additive to parenteral chemotherapy. blocking the over-reacting cell-med ...	1990	2286734
[a case of recurrent circinate erythematous psoriasis (lapière)].	the authors report a case of infantile recurrent circinate erythematous psoriasis, as described by lapière, in a nine year old child. particular features of the case are the relative rarity of the disease that shows a benign chronic recurrent course.	2008	2289816
high-performance liquid chromatography of retinoids in blood.		2008	2292964
selection for vancomycin resistance in clinical isolates of staphylococcus haemolyticus.	killing curves were used to characterize staphylococcus haemolyticus isolates previously reported to contain subpopulations showing increased resistance to vancomycin. results suggested that vancomycin and teicoplanin were ineffective at a concentration of 8 micrograms/ml and growth was seen between 24 and 48 h. conversely, the lipopeptide antibiotic daptomycin at the same concentration rapidly killed tested strains by 6 h. various staphylococcal strains were examined to determine if vancomycin ...	1990	2295858
reactivity of coagulase-negative staphylococci isolated from cow and goat milk with monoclonal antibodies to staphylococcus aureus capsular polysaccharide types 5 and 8.	monoclonal antibodies to staphylococcus aureus capsular polysaccharide types 5 and 8 were used in an enzyme-linked immunosorbent assay to serotype 74 and 42 coagulase-negative isolates from cow and goat milk, respectively. eighteen (15.5%) isolates were typable: 13 staphylococcus haemolyticus, 1 s. hyicus, 1 s. simulans, and 1 s. warneri from bovine origin and 2 s. lentus from caprine origin. type 5 was predominant, accounting for about 89% of typable isolates. reactivity with monoclonal antibod ...	1990	2312680
peripheral teflon catheters. potential source for bacterial contamination of orthopedic implants?	to detect low numbers of bacterial cells on teflon catheters removed from peripheral veins, 74 catheter tips were incubated in thioglycollate media for up to ten days. fifteen (20.3%) of the catheters were found to be culture-positive. propionibacterium acnes was isolated from seven, staphylococcus epidermidis from six, and staphylococcus haemolyticus and staphylococcus hominis from one each, all common skin organisms associated with infection of implants. an increase in documentation of bacteri ...	1990	2323139
staphylococcal enterotoxins direct and trigger ctl killing of autologous hla-dr+ mononuclear leukocytes and freshly prepared leukemia cells.	attempts have been made to induce cytolytic t cells to kill target cells that do not express the appropriate target molecules by crosslinking the t cells and the target cells in various ways. one successful strategy has been to use heteroconjugates or bispecific monoclonal antibodies reacting with t cell molecules with activating properties (e.g., mab directed to cd3/tcr) and target cell surface antigens. in this report we show that staphylococcal enterotoxins (se) direct human t lymphocytes to ...	1990	2383900
[empirical treatment of febrile episodes in granulocytopenic patients with a combination of piperacillin and ofloxacin. preliminary study].	we evaluated the efficacy and toxicity of piperacillin-ofloxacin as an empiric treatment of fever in patients with neutropenia. 24 febrile episodes occurring in 21 patients (mean neutropenia: 204/mm3) were treated. the neutropenia was due to an hematologic malignancy in 6 cases and to chemotherapy in 15 cases. fever was related to septicemia in 4 cases, urinary tract infection in 1 case, other infectious sites without microbiological documentation in 11 cases, and was of unknown origin in 8 case ...	1990	2385453
haemophilus influenzae bartholinitis.		1990	2387300
effects of retrograde flow on measured blood volume, disse space, intracellular water space and drug extraction in the perfused rat liver: characterization by the multiple indicator dilution technique.	previous rat liver perfusion studies had shown a preferential derecruitment of downstream (phenacetin o-de-ethylation) in relation to upstream (acetaminophen sulfation) hepatocyte activities with reductions in prograde (normal) flow, with substrates entering from the portal vein and exiting the hepatic vein. the reduction in metabolic activities was found associated with a reduction in accessible intracellular water space (pang et al., j. pharmacokinet. biopharm. 16: 595, 1988). in the present s ...	1990	2395120
keratinolytic activity of cutaneous and oral bacteria.	a test was developed to measure the keratinolytic activity of cutaneous and oral bacteria. keratin, labeled with fluorescein isothiocyanate, was used in a phosphate buffer (ph 7.2) with 1 mm dithiothreitol. the degradation of keratin was estimated by measuring the fluorescence of the degradation products in the supernatant of the reaction mixtures in a luminescence spectrometer. several oral and cutaneous bacteria were investigated: bacteroides gingivalis, bacteroides intermedius, treponema dent ...	1987	2434427
comparison of the acute phase response of cultured morris hepatoma 7777 cells and of rat hepatocytes.	isolated morris hepatoma cells (line 7777) or adult rat hepatocytes were cultured for 3 days and daily production of four plasma proteins was estimated in the cell media by rocket immunoelectrophoresis with monospecific antisera. addition of cytokines from rat peritoneal macrophages to cultured hepatocytes or hepatoma cells augmented accumulation in the medium of two positive acute phase proteins: fibrinogen (fib) and cysteine proteinase inhibitor (cpi). at the same time synthesis of alpha-fetop ...	1987	2443154
blast colonies containing hemopoietic progenitor cells can give rise to abelson virus (a-mulv)-transformed cell lines.	we have established an in vitro system with which to examine the ability of abelson murine leukemia virus (a-mulv) to infect early hemopoietic progenitor cells. blast cell colonies containing less than 100 cells were shown to contain up to 85% of cells with secondary hemopoietic colony-forming ability. infection of cells from these blast colonies resulted in generation of transformed mast cell lines when a feeder was provided. morphological examination of cells taken from infected cultures at va ...	1988	2446900
activation of the mas oncogene during transfection of monoblastic cell line dna.	using the tumorigenicity assay, we observed an activation of the mas oncogene during transfection of human acute myelocytic leukemia (ctv-2) dna. respective transfectants contained amplified mas sequences characterized by rearrangements in 5' and 3' noncoding regions that were transcribed into a 3.3 kb mas rna species. our data represent the second report on activation of the mas gene.	1988	2453759
monitoring during sedation for endoscopy.		2008	2493279
[studies of the antigenic structure of trichophyton equinum].	in the studies on antigenic structure of t. equinum double diffusion precipitation test in agar gel and immunoelectrophoresis were used. while preparing precipitation sera in rabbits it was manifested that the best results are achieved by immunization with live antigen. in the group of metabolic antigens and water extracts of the strains of t. equinum which were tested, 10-11 serologically+ active fractions were found whereas in protein component only l1 fraction. in comparative studies based on ...	1989	2518619
[value of 2-dimensional echocardiography in infective endocarditis].	we analyzed the two dimensional echocardiograms (2d echo) of 41 patients with infective endocarditis (ie). the diagnosis of endocarditis was based on typical clinical findings, positive blood cultures or anatomical findings at operation or necropsy. age ranged from 21 to 73 years. endocarditis was localized in a native valve in 30 patients (aortic 18, mitral 11 and tricuspid 1), a biologic prosthesis in 9 (mitral 4, aortic 4, unknown 1) and a mechanical valve in 4 (aortic 3, mitral 1). the echoc ...	2008	2519354
[biliary scintigraphy in patients with functional disorders of oddi's sphincter].	the appearance of biliary pain after cholecystectomy in patients with normal ultrasonic and cholangiographic studies has been attributed to functional alterations of the sphincter of oddi. we performed dynamic cholescyntigraphic studies of the biliary tract in 32 cholecystectomized patients, at least six months after the operation: 27 were asymptomatic (control group) and 5 had clinical and laboratory findings suggesting temporary functional obstruction of the sphincter of oddi. in this group we ...	2008	2519463
[staphylococcus haemolyticus. bacterial resistance to teicoplanin and associated morpho-structural aspects].	to improve our understanding of the bases of teicoplanin resistance we studied a "one-step" mutant of s. haemolyticus from a morphological point of view. the results show that the organization of peptidoglycan is altered in the resistant s. haemolyticus strain. it is suggested that the alterations, including the spongier cell wall structure, may prevent the teicoplanin from reaching its target.	1989	2533873
susceptibility of gram positive cocci to teicoplanin. three year survey (1984-1986) at perugia university.	from 1984 to 1986, 1038 gram positive cocci (865 staphylococci and 173 enterococci) have been tested for sensitivity to teicoplanin by the agar diffusion method: only one strain (staphylococcus haemolyticus) resulted to have no zone of inhibition around the teicoplanin disk. all staphylococcus haemolyticus strains showed higher mic: 2.79 mcg/ml after 24h of incubation and 20.50 mcg/ml after 48h. the reduced teicoplanin sensitivity of staphylococcus haemolyticus was not detected by the agar diffu ...	1989	2535245
activities of daptomycin and teicoplanin against staphylococcus haemolyticus and staphylococcus epidermidis, including evaluation of susceptibility testing recommendations.	the in vitro activities of daptomycin, teicoplanin, and three other antimicrobial agents were determined against 105 strains of staphylococcus haemolyticus and 92 strains of staphylococcus epidermidis. the mics for 90% of strains tested (mic90s) of fusidic acid and rifampin were less than or equal to 0.25 microgram/ml. the mic90s of daptomycin and vancomycin were less than or equal to 4 micrograms/ml. teicoplanin had a comparable mic90 of less than or equal to 4 micrograms/ml for isolates of s. ...	1989	2543286
a b-type pdgf receptor lacking most of the intracellular domain escapes degradation after ligand binding.	the characteristics of the human b-type platelet-derived-growth-factor (pdgf) receptor expressed in chinese hamster ovary (cho) cells, were compared with those of a mutant receptor lacking all but 19 amino acids of the intracellular domain. the transfected wild-type receptor was synthesized as a 160-kda precursor that was processed to 190 kda. each cho cell expressed 30,000-100,000 receptors which bound pdgf-bb with a kd of about 0.5 nm. analysis of pdgf-ab binding yielded non-linear scatchard p ...	1989	2546765
intensive chemotherapy in sclc.		2008	2546777
rfrap: a computer program for analysis of complex hla rflps. assignment of restriction fragments to haplotypes by segregation analysis.	the availability of hla class ii cdna probes has led to the development of a powerful method for the discrimination of genetic variation in this region of the major histocompatibility complex. there are problems with this approach which reduce its usefulness, including the hybridization of a probe with multiple restriction fragments (rfs) from the same locus or of two different cdna probes with the same rf (cross-hybridizing). these problems may now be largely overcome by the relatively simple c ...	2008	2565894