Publications

[aneurysm of the pancreaticoduodenal arteries and stenosis of the celiac trunk. apropos of a case].	the authors describe the different imaging techniques and their interest. they discuss their etiology. the association with stenosis of the coeliac axis incites to think at a hemodynamic theory.	2009	2681728
airway obstruction due to goiter in older patients.	it has been shown that goiters can progressively enlarge to compress the surrounding trachea or esophagus and result in incapacitating obstructive symptoms or potentially fatal airway obstruction. the potential of a goiter to become hyperactive also exists. recently, we have seen three older patients with longstanding untreated "benign" goiters who presented difficult management decisions. given the likelihood of progressive growth of a goiter and the increased life expectancy of these patients ...	2009	2687351
long-term results of prosthetic therapy in adult cleft lip alveolus and palate patients.	in the framework of the complex rehabilitation of cleft lip and palate patients the final phase of the dental therapy is attained with the definitive prosthetic treatment. this study comprises 148 prosthetically treated patients in the period 1973 to 1986. the results show that there are good preconditions for an undisturbed professional and social development of the cleft lip and palate patients through intensive dental care.	2008	2691535
care of pressure sores: a controlled study of the use of a hydrocolloid dressing compared with wet saline gauze compresses.	an occlusive hydrocolloid dressing (comfeel ulcus) was compared with a conventional wet saline gauze dressing regarding the effect on ulcer cleansing and healing processes, experience of pain and the consumption of nursing time, in a controlled, randomized and partially single-blind study with parallel groups of long-stay patients with pressure sores. after a few weeks' treatment the relative decrease in ulcer areas with time was larger in the group treated with the hydrocolloid dressing. the di ...	2008	2694713
[clinico-morphological characteristics of extrahepatic pathology caused by the hepatitis b virus].	the current literature and the authors data on the clinics and morphology of the extrahepatic (visceral) pathology provoked by the hepatitis virus are analysed.	1989	2698128
[initial experiences with a monoclonal antibody to the progesterone receptor complex].	today, the immuncytochemical demonstration of estrogen receptors can be regarded as established. recently, a monoclonal antibody (mab) against the progesterone receptor-complex became commercially available. the antibody mi 60-10, developed by milgrom and co-workers, is murine and principally directed against the progesterone receptor of the rabbit, but it also attacks an "epitop" of the human receptor. the western-blot analysis shows the antibody having several specific bands against t-47-d cel ...	1989	2703136
sce induction by ccnu and pregnancy.		2009	2704378
lack of co-transmission of rickettsia conorii and ehrlichia canis in human beings in the south of france.	ehrlichia canis is the agent of canine ehrlichiosis, commonly known as canine tropical pancytopenia. this canine disease is frequent in our area, as is mediterranean spotted fever in humans. recently a few cases of human ehrlichiosis have been described in the usa. the supposed vector of both diseases is rhipicephalus sanguineus. in order to evaluate the co-transmission of these two diseases, we selected 498 human sera positive for r. conorii and tested them for ehrlichia canis. none of them wer ...	1989	2707389
brain biocompatibility of a biodegradable, controlled-release polymer in rats.	we report the biocompatibility in the rat brain of a controlled-release, biodegradable polymer, the polyanhydride poly-[bis(p-carboxyphenoxy)propane-sebacic acid] copolymer (pcpp-sa) in a 20:80 formulation. the biodegradable polyanhydride can be used for drug delivery directly into the brain, circumventing the difficulties posed by the blood-brain barrier and avoiding the consequences of having to administer toxic doses systematically to reach therapeutic doses in the central nervous system. the ...	1989	2708412
infection with ehrlichia canis in a child.		1989	2715894
aseptic meningitis associated with ehrlichia canis infection.		1989	2726324
development of neural inducing capacity in dissociated xenopus embryos.	during gastrulation in amphibians, dorsal ectoderm is converted by induction from an epidermal pathway to central nervous system (cns). we show in this report that the ability of the embryo to manufacture this neural inducing signal is not dependent upon intercellular communication between early cleavage and early gastrula stages. this result is consistent with the interpretation that the cell lineage that induces cns formation arises itself by a cell-autonomous mechanism, perhaps specified by m ...	2009	2731653
desipramine isn't when it's disopyramide.		2009	2739015
[efficacy of diltiazem in blood pressure increase caused by exertion].	after examining the properties of the 3 most widely used calcium antagonists, the paper assesses the efficacy of diltiazem in reducing blood pressure rises after exercise in a group of 7 patients with chronic atrial fibrillation. the blood pressure response to a standard load (50 w x 3 m2) on the exercise cycle was monitored in a group of patients under chronic digitalis treatment (phase i) after which the same patients' response to varying doses of diltiazem (180-240 mg/day) was assessed (phase ...	2009	2747939
pharmacokinetic and metabolic studies of high-dose busulphan in adults.	the pharmacokinetics of high-dose busulphan was studied in adult patients with acute myeloblastic leukaemia after oral doses of 1 mg.kg-1 every 6 h for 4 days. the mean steady-state plasma concentration was 1080 ng/ml-1 during the treatment. individual steady-state concentrations after the last dose on average were 32% lower than those predicted from total auc measurements following the first dose. mean elimination half-life in plasma was 2.3 h after the last dose and 3.4 h after the first dose ...	1989	2753072
ehrlichia canis infection in a child.		1989	2771561
[urologic examination and treatment of patients with acute injuries of the spinal medulla].	during a period of one year, nine patients with traumatic lesions of the spinal medulla were examined and treated urologically. the patients were followed-up for 24-36 months and follow-up will continue. all of the patients were treated primarily with sterile intermittent catheterization by the nursing staff. exceptions from this were patients in whom indwelling catheters were necessary on account of complicating conditions. during the acute phase, the patients were examined by a urologist and b ...	2009	2773121
[left ventricular pressure-volume diagram determined by forward and backward formatting of radionuclide ventriculography and analog pressure data].	pressure-volume (pv) loop is of great value for the assessment of left ventricular (lv) function, but its clinical application has been limited by methodological complexity. a new system was developed to make accurate loop with simplified procedure, and was applied to clinical and interventional study. the system constitutes of a mobile gamma camera, a poly-amplifier and a data processor (gms-550u, toshiba medical) installed in cardiac catheterization labo for simultaneous raw data handling and ...	2009	2786583
elevation of factor vii activity and mass in young adults at risk of ischemic heart disease.	the northwick park heart study found that elevation of factor vii in middle-aged subjects was an independent risk factor for subsequent ischemic heart disease. the present study was designed to determine whether factor vii elevation is present at a younger age and whether zymogen or activated factor vii is responsible for this elevation. a group of 20 asymptomatic first degree relatives (mean age 34.9 years) of patients with premature ischemic heart disease were compared with 15 age-matched norm ...	2009	2794283
three views on unified membership.		2009	2797824
three views on unified membership.		2009	2797824
modelling of reference values for size at birth.	data from the swedish medical birth registration, 1977-1981 were used to apply methods of constructing reference standards for size at birth. using clinical information a 'healthy' sub-population was extracted. the conditional distributions of birthweight (bw) and birthlength (bl) for each week of gestational age, and the conditional distribution of birthweight given birthlength were modelled using truncated normal distributions, after making use of box-cox power transformations. spline function ...	2009	2801107
the development of analytical models for human trypanosomiasis.	the idea of biological equilibria is presented and applied first to the case of single species populations. difference and differential descriptions of population changes over time are compared and contrasted. the complications that arise when describing interactions between species are then illustrated for the case of vector-borne diseases, such as malaria. a simple model for malaria is explored and later extended to the case of the african trypanosomiases where more than one vertebrate host sp ...	1989	2802828
human ehrlichiosis: prospective active surveillance in febrile hospitalized patients.	between 1 april 1987 and 30 september 1988 prospective active surveillance of human ehrlichiosis was conducted among febrile patients hospitalized in southeast georgia. if disease of the immune system, bacterial infection, pneumonia, or surgical illness was documented by the end of the first full day of hospitalization, the patient was excluded. of 75 patients enrolled in the study, 8 (10.7%) had a fourfold rise or fall in titer to ehrlichia canis (case-patients). the rate was 5.3 cases/100,000 ...	1989	2809255
[europe 1992: big brother is watching you].		2009	2812101
[europe 1992: big brother is watching you].		2009	2812101
[written information on prescribed drugs provided by pharmacies].		2009	2815030
[written information on prescribed drugs provided by pharmacies].		2009	2815030
allograft tolerance induction in adult mice associated with functional deletion of specific ctl precursors.	rejection of h-2 class i bm 1 mutant skin allografts by b6 recipient mice is mediated by a population of cd8+ anti-bm1 cytotoxic t-lymphocytes that produces and consumes its own t helper factor in response to bm1 skin allografts (dual function ctl). previously we have demonstrated that transfusion of allogeneic lymphocytes across an h-2 class i disparity induces specific long-lasting skin allograft survival. we now show that intravenous injection of allogeneic spleen cells across the bm1 mutant ...	2009	2815256
allograft tolerance induction in adult mice associated with functional deletion of specific ctl precursors.	rejection of h-2 class i bm 1 mutant skin allografts by b6 recipient mice is mediated by a population of cd8+ anti-bm1 cytotoxic t-lymphocytes that produces and consumes its own t helper factor in response to bm1 skin allografts (dual function ctl). previously we have demonstrated that transfusion of allogeneic lymphocytes across an h-2 class i disparity induces specific long-lasting skin allograft survival. we now show that intravenous injection of allogeneic spleen cells across the bm1 mutant ...	2009	2815256
similarities and differences in the regulation of hepatic cytochrome p-450 enzymes by diabetes and fasting in male rats.	the effects of streptozotocin-induced diabetes and fasting on hepatic cytochrome p-450 enzymes in sexually mature male rats were studied by immunochemical techniques and enzyme assays. the level of cytochrome p-450ac (an acetone/ethanol inducible form), 65 pmol/mg microsomal protein in control rats, increased 4- to 5-fold in diabetic rats and 3- and 5-fold in fasting rats. in contrast, p-450 ut-a (a male specific form) decreased drastically from 295 pmol/mg in the control group to about 10% of t ...	1989	2818618
t-butyl-4-hydroxyanisole as an inhibitor of tumor cell respiration.	the effect of t-butyl-4-hydroxyanisole (bha), a widely used food antioxidant additive, on the culture growth, oxygen consumption, and redox state of some electron carriers of intact ta3 and 786a ascites tumor cells has been studied. bha inhibited culture growth and respiration of these two tumor cell lines, by inhibiting the electron flow through the respiratory chain. experiments to determine its site of action showed that bha did not inhibit noticeably the electron flow through cytochrome oxid ...	2010	2818635
reinfection of guinea pigs with herpes simplex virus type 2: failure to establish a second latent ganglionic infection.	guinea pigs were infected with herpes simplex virus type 2 (hsv 2) and at various times thereafter reinfected at a different site with the same or a different strain of hsv 2. viruses were isolated from infected tissues either from the site of primary or secondary infection or from regional ganglia. viral isolates were characterised by dna fingerprinting using restriction endonucleases capable of differentiating between the virus strains used. the second infection resulted in a second site of pe ...	1987	2825951
two mutant alleles of the insulin receptor gene in a patient with extreme insulin resistance.	insulin receptor complementary dna has been cloned from an insulin-resistant patient with leprechaunism whose receptors exhibited multiple abnormalities in insulin binding. the patient is a compound heterozygote, having inherited two different mutant alleles of the insulin receptor gene. one allele contains a missense mutation encoding the substitution of glutamic acid for lysine at position 460 in the alpha subunit of the receptor. the second allele has a nonsense mutation causing premature cha ...	1988	2834824
two mutant alleles of the insulin receptor gene in a patient with extreme insulin resistance.	insulin receptor complementary dna has been cloned from an insulin-resistant patient with leprechaunism whose receptors exhibited multiple abnormalities in insulin binding. the patient is a compound heterozygote, having inherited two different mutant alleles of the insulin receptor gene. one allele contains a missense mutation encoding the substitution of glutamic acid for lysine at position 460 in the alpha subunit of the receptor. the second allele has a nonsense mutation causing premature cha ...	1988	2834824
[possibility of the early diagnosis of the suture incompetence of a large intestine anastomosis].	radionuclide examinations consisting in intraoperative injection of a nonabsorbed radiopharmaceutical preparation into the lumen of adducting portion of the gut were proposed for the detection of incompetence of anastomosis sutures in the early postoperative period. the investigation was performed in 45 patients. complications on the anastomosis were detected in 7 patients: in 5 patients--anastomositis, in 2 patients--incompetence of the anastomosis sutures, the radiopharmaceutical preparation b ...	2010	2836984
effect of dietary fiber on the metabolizable energy of human diets.	two diets consisting of natural foods that differed in fiber content were fed to 12 men for 6 wk each in a crossover design. diet 1 contained 37 g total dietary fiber (tdf) from fruits and vegetables and diet 2 contained 16 g tdf from fruit and vegetable juices in a 2800-kcal menu. seven-day food, urine and fecal composites were made and analyzed for their gross energy, fat, protein and carbohydrate content during the fourth and fifth weeks of each dietary consumption period. the metabolizable e ...	1988	2843615
effect of exercise training in patients with essential hypertension.	the aim of the present study was to examine the effect of regular exercise training in moderate essential hypertension. twenty subjects (one woman and 19 men) trained for 45 minutes three times a week for 12 weeks, to 60% of their maximal heart rate. blood pressure was measured at rest and during a maximal exercise test on bicycle ergometer. all subjects achieved training effect measured as a significant reduction in heart rate at comparable submaximal work level and a significant increase in du ...	2010	2856772
production in nature of compound resembling methylphenyltetrahydropyridine, a possible cause of parkinson's disease.		2007	2857280
the smoking gun.		2010	2857863
thalidomide, orogenital ulcers, and risk of teratogenicity.		2010	2857866
structural bases of the cytolytic mechanisms of entamoeba histolytica.	the cellular bases of the powerful cytolytic activity of the human protozoan parasite entamoeba histolytica were explored by studying the effect of the virulent strain hm1:imss on epithelial monolayers of mdck cells using a combination of time-lapse microcinematography and transmission and scanning electron microscopy. early alterations of the epithelial cell membranes were detected by measuring changes in the transepithelial electrical resistance of mdck monolayers mounted in ussing chambers. t ...	1985	2859368
hepatitis b vaccine with and without polymerised albumin receptors.		2010	2860351
rhesus haemolytic disease treated with high-dose intravenous immunoglobulin.		2010	2860352
truth, trust, and paternalism.	the emphasis on the necessity for fully informed consent in two new books, doctors' dilemmas by m. phillips and j. dawson and whose body is it? by c. faulder, is found to be "lacking in balance" by brewin. the doctor's discretion in dealing with each patient is considered to be the key to determining priorities between paternalism and communication. rigid rules, brewin argues, may not be in the patient's best interest and thus should not be forced on doctors and nurses by "philosophers or expert ...	2010	2863503
therapeutic drug monitoring.		2010	2863512
mechanisms of autoimmunity.		2010	2865458
chronic stimulation modifies the isotonic shortening velocity of denervated rat slow-twitch muscle.	rat soleus muscles were denervated and stimulated in vivo for periods of up to 104 days. stimuli used were trains of 1 ms pulses at 100 hz delivered for periods of 1 s; trains were repeated every 10-100 s. in a majority of animals the tension of the muscles was maintained at about 10% of normal, equivalent to muscles denervated but unstimulated for 20 days. at the longest periods the stimulated muscles developed ten times more tension than ones that were denervated but not stimulated. in denerva ...	1986	2874561
[beta-adrenergic blockers].		2010	2876553
a case of wound botulism.		2010	2882064
striatal grafts in rats with unilateral neostriatal lesions--i. ultrastructural evidence of afferent synaptic inputs from the host nigrostriatal pathway.	tyrosine hydroxylase immunocytochemistry, in combination with golgi impregnation, has been used to study the dopaminergic afferent input to striatal suspension grafts implanted into the previously ibotenic acid-lesioned striatum in adult recipient rats. the rats were perfused for combined light- and electron microscopy at 10-11 months after transplantation, at the end of a series of behavioural experiments and a study of in vivo gaba release, reported in the two accompanying papers. a tyrosine h ...	1988	2898109
the repairability of oxidative free radical mediated damage to dna: a review.	many dna repair enzyme activities are present in both prokaryotic and eukaryotic organisms. among these are dna exo- and endonucleases and dna glycosylases which remove oxidatively damaged portions of the dna molecule, thereby initiating excision-repair. the existence of these enzymes may be taken as evidence that cellular dna is continuously subject to endogenous oxidative stress. many of the lesions introduced by ionizing and ultraviolet radiation are identical to those introduced into dna by ...	2010	2900272
mutational analysis of domain i of pseudomonas exotoxin. mutations in domain i of pseudomonas exotoxin which reduce cell binding and animal toxicity.	pseudomonas exotoxin (pe) is a single polypeptide chain that contains 613 amino acids and is arranged into three structural domains. domain i is responsible for cell recognition, ii for translocation of pe across membranes and iii for adp ribosylation of elongation factor 2. treatment of pe with reagents that react with lysine residues has been shown to lead to a reduction in cytotoxic activity apparently due to a modification of domain i (pirker, r., fitzgerald, d. j. p., hamilton, t. c., ozols ...	1988	2901411
duration of ischemia is vital for collateral development: repeated brief coronary artery occlusions in conscious dogs.	the effects of two types of repeated transient coronary artery occlusions on collateral development were examined in chronically instrumented, conscious dogs. a 2-minute coronary occlusion at 32-minute intervals (group 1, n = 11) or a 15-second occlusion at 4-minute intervals (group 2, n = 7) were repeated day and night without interruption. in both groups, the total duration of coronary occlusions each day was the same (90 minutes). before and after repetitive occlusions of either group, effect ...	1989	2912600
parents and cataract kids. supporting the family to treat the child.		2009	2913319
an outbreak of ehrlichiosis in members of an army reserve unit exposed to ticks.	an outbreak of unexplained illness occurred in members of an army reserve unit after field training in an area of new jersey endemic for lyme disease. nine (12%) of the 74 who attended the exercise had serological evidence of ehrlichia infection, defined as a single rise in titer of antibody to ehrlichia canis greater than or equal to 1:160 four weeks after training. two reservists with early serum samples had documented seroconversion, defined by a four-fold or greater increase in titer of anti ...	1989	2915168
analysis of the early rise in aortic transvalvular gradient after aortic valvuloplasty.	the relationship between dynamic changes in aortic valve gradient and left ventricular ejection performance in the early period after successful percutaneous aortic valvuloplasty has not been described in detail. accordingly 20 adult patients with severe symptomatic calcific aortic stenosis underwent first-pass radionuclide angiography and doppler echocardiography before, immediately after, and 2 to 4 days after the valvuloplasty procedure. a significant (p less than 0.001) reduction in peak-to- ...	2010	2916414
glucocorticoid receptor activation in isolated perfused rat hearts.	the formation of unactivated and activated glucocorticoid receptor complexes was studied in intact, isolated, perfused rat hearts in the presence of [3h]triamcinolone acetonide. receptor activation, as quantified by the dna-cellulose-binding assay, began to increase within 30 s of perfusion and reached a final steady-state level (t 1/2 = 4.6 min) with 46% of the steroid-receptor complexes bound to dna-cellulose. with the use of a linear potassium phosphate (kp) gradient (5-400 mm), unactivated r ...	1989	2919654
diarrhoeal diseases: perceptions and practices in nepal.	a study undertaken in nepal collected information on believed causes of diarrhoea and traditional treatments. natural causes for diarrhoea were more frequently reported than supernatural causes, the most important being teething (75% of respondents reporting it to be a cause) followed by food considered to be 'cold' in the hindu ayurvedic classification (57.5%), stale food (52.5%), hot food (41%) and dirty water (38%). the terminology reported for dehydration however, indicates strong links with ...	2009	2928835
inflammatory pseudotumor of the liver. report of the fine needle aspiration cytologic findings in a case initially misdiagnosed as malignant.	the fine needle aspiration (fna) cytologic features are described in a case of inflammatory pseudotumor of the liver (xanthogranuloma), a disease generally regarded as of unknown etiology. the initial fna findings were those of an acute exudative process, with atypical biliary duct epithelium and hepatocytes. these were interpreted as verifying the radiologic impression of a malignancy. histologic study of subsequently resected nodules revealed the true nature of the case. as the lesion evolved, ...	2010	2929226
plasma beta-endorphin immunoreactivity (pl-beta-ed-ir) in patients with ulcer disease and its management by acute and chronic administration of gastrozepin.	the initial level of pl-beta-ed-ir was significantly lowered in a group of 14 patients with gastroduodenal ulcer disease as compared with healthy volunteers (p less than 0.05). immediately after i.m. administration of 20 mg gastrozepin (g) the pl-beta-ed-ir level increased but not significantly. given orally over two weeks, g (50 mg/day) led to a more than doubling of the initial level (p less than 0.05). controls showed no significant changes. a further meaningful change represented the time re ...	2010	2937705
enzymatic cleavage of various fluorinated pyrimidine nucleosides to 5-fluorouracil and their antiproliferative activities in human and murine tumor cells.		1986	2951016
[accumulation of messenger rna of the atrial natriuretic factor in the rat left ventricle at the compensatory hypertrophy stage in pressure overload].	the atria produce several peptides that have natriuretic and vasoactive properties, collectively called atrial natriuretic factor. all these peptides share a single messenger ribonucleic acid, the amount of which greatly increases in the rat left ventricle when the latter is submitted to chronic volume overload. using the molecular hybridization technique and a desoxyribonucleic acid probe complementary to the atrial natriuretic factor messenger ribonucleic acid, we now report that a very import ...	1987	2957027
[adp ribosylation: knowledge and perspectives].	polyadenosine diphosphate ribose (polyadpr) and polyadpr-polymerase (polyadpr-p) were discovered in our laboratory in 1966. then it has been demonstrated that the enzyme and the polymer exist in all eukaryotic cells and catalyze a transfer of adp-ribose moieties to proteins. ever increasing evidence favours an involvement of the enzyme through protein adp-ribosylation in dna duplication, transcription and repair. recently the existence of poly or oligo adp-ribosyl transferases were demonstrated ...	2010	2957029
[heterogeneity of purinergic p2 receptors at the level of the caudal artery of the rat and the saphenous vein of the dog].	phentolamine (10(-5) m) and an inhibitor of the lipoxygenase pathway, nordihydroguaiaretic acid (n. d. g. a.; 8 10(-6) m) antagonized the atp induced contraction but not antagonized the utp induced contraction on both rat tail artery and dog saphenous vein. we conclude that the receptors to atp are distinct from receptors to utp and that the p2 purinoceptors are an heterogeneous group.	1987	2957036
transport of light in tissue in photodynamic therapy.		2010	2964653
comparative study of biarison and voltaren in acute lumbar pain and lumbo-ischialgia.		2010	2964738
stimulation of growth hormone secretion by central administration of atrial natriuretic polypeptide in the rat.	intracerebroventricular (icv) injection of alpha-human atrial natriuretic polypeptide (alpha hanp) or alpha-rat anp (0.6 and 3 nmol/rat) elicited an increase in plasma gh levels both in conscious freely moving rats and in urethane-anesthetized rats when given at the trough of spontaneous gh secretion. antiserum specific for rat grf did not affect the plasma gh increase induced by icv injection of alpha hanp. intracerebroventricular injection of alpha anp (3 nmol/rat) failed to stimulate gh secre ...	1988	2966063
atrial natriuretic factor: physiologic actions and implications in congestive heart failure.	atrial natriuretic factor (anf) represents a newly recognized hormone of cardiac origin. this peptide is synthesized by the myocardial cells of both atria and released by atrial stretch. the hormone promotes sodium and water excretion by the kidney, inhibits the renin-angiotensin-aldosterone system, and reduces systemic arterial pressure. specific receptors for anf are present in the kidney, adrenal glands, vascular smooth muscle, platelets and central nervous system. congestive heart failure is ...	1987	2978996
origin of leukemic relapse after bone marrow transplantation detected by restriction fragment length polymorphism.	bone marrow transplantation has become an accepted modality in the treatment of acute leukemia. with this therapy, it is possible to obtain long-term disease-free survival. however, leukemia recurs occasionally. in most cases, leukemic relapse is of recipient origin. there have been several reports, though, of leukemia developing in donor cells. these cases have been limited to instances in which there is an easily identifiable chromosome difference or abnormality, usually a sex chromosome. in t ...	2010	2981254
adaptation of ehrlichia sennetsu to canine blood monocytes: preliminary structural and serological studies with cell culture-derived ehrlichia sennetsu.	ehrlichia sennetsu, the causative agent of human sennetsu rickettsiosis, was successfully propagated in primary canine blood monocyte cultures. the growth cycle of this organism appears to be similar to that of ehrlichia canis. the antigen derived from our e. sennetsu cultures was used to develop an indirect fluorescent antibody test for detection and titration of serum antibodies to the organism. using this test system, we found that five human serum samples obtained from patients clinically di ...	1985	2985504
binding characteristics of swine erythrocyte insulin receptors.	crossbred gilts (controls; n = 7) had 8.8 +/- 1.1% (mean +/- sem) maximum binding of [125i]insulin to insulin receptors on erythrocytes. the number of insulin-binding sites per cell was 137 +/- 19, with a binding affinity ranging from 7.4 x 10(7)m-1 to 11.2 x 10(7)m-1 and mean of 8.8 x 10(7)m-1. pregnant sows (n = 5) had a significant increase (p less than 0.01) in maximum binding due to an increase in number of receptor sites per cell. lactating sows fed a high-fiber diet (n = 3) and a low-fibe ...	1985	2996389
the role of structure in the disposition of halogenated aromatic xenobiotics.	halogenated aromatic xenobiotics such as the chlorinated and brominated biphenyls, naphthalenes, dibenzodioxins, and dibenzofurans are widespread environmental contaminants. the number, position, and nature of the halogen atoms as well as the structure of the aromatic rings influence the disposition of these chemicals in living systems. absorption is governed primarily by the physical properties of lipophilicity and solubility. distribution through the blood occurs by nonspecific binding to plas ...	1985	2998745
prevalence of cytomegalovirus antibodies in thai blood donors.	antibodies to cytomegalovirus (cmv) were determined in thai blood donors using the complement fixation (cf) test and enzyme-linked immunosorbent assay (elisa). a total of 203 voluntary blood donors, 181 males and 22 females, who came to the blood bank at siriraj hospital during february 1985, were investigated. their ages ranged from 17 to 53 years (mean 24.3 +/- 6.9). seventy-three out of 156 (46.8%) and 171 out of 203 (84.2%) sera were positive for cmv antibodies as detected by the cf test and ...	1985	3000401
the inhibition of progesterone secretion and the regulation of cyclic nucleotides by atrial natriuretic factor in gonadotropin responsive murine leydig tumor cells.	we have found that atrial natriuretic factor (anf) has a profound effect on testicular cells in altering intracellular cyclic nucleotide levels as well as progesterone secretion. using clonal cultured leydig tumor cells we found that 1 x 10(-8)m anf caused a two thousand-fold elevation in the accumulation of cellular cgmp and inhibited camp in treated cells by more than 90% as compared to the controls. anf (1 x 10(-8)m) also significantly inhibited gonadotropin-stimulated accumulation of camp in ...	1985	3002360
[cyclic amp- and atp-mediated stimulation of dna synthesis following partial hepatectomy by prostaglandin-e1 in d-galactosamine injured liver].	d-galactosamine (d-gal) damaged rats were infused with prostaglandin e1 (pge1) through a peripheral vein for 40 min. before and after partial hepatectomy. dna synthesis following 68% partial hepatectomy was severely inhibited by the pretreatment of d-galactosamine. pge1 infusion (0.5, 1.0 microgram/kg/min) enhanced the dna synthesis inhibited by d-gal 600 mg/kg significantly (p less than 0.01). after 20 min. of pge1 infusion cyclic amp levels of liver tissue was increased as compared with saline ...	1985	3003557
human papillomavirus types 16 and 18 sequences in early cervical neoplasia.	a total of 100 colposcopic biopsies from patients with abnormal papanicolau's tests were surveyed for the presence of human papillomavirus (hpv) types 16 and 18 sequences by spot-blot hybridization. hpv 16 and 18 dna sequences were detected in 58% of the biopsies. none of the cervical intraepithelial neoplasia grade i (cin i) contained hpv 16 while 50% of the cin iii lesions (carcinoma in situ, cis) contained hpv 16. hpv 18-related sequences were equally represented in cin i, ii, and iii. southe ...	1986	3022464
downstream sequences affect transcription initiation from the adenovirus major late promoter.	we analyzed a set of adenovirus-simian virus 40 (sv40) hybrids in which the sv40 t antigen coding sequences are inserted downstream from the adenovirus major late promoter within the first, second, and third segments of the tripartite leader. in infected cells, these viruses give rise to a matched set of hybrid sv40 mrnas that differ only in the number of tripartite leader segments attached to the complete sv40 t antigen coding region. we found that the number of tripartite leader segments prese ...	1986	3023944
cloning and characterization of the high-affinity camp phosphodiesterase of saccharomyces cerevisiae.	a gene, pde2, has been cloned from the yeast saccharomyces cerevisiae that, when present in high copy, reverses the phenotypic effects of ras2val19, a mutant form of the ras2 gene that renders yeast cells sensitive to heat shock and starvation. it has previously been shown that the ras proteins are potent activators of yeast adenylate cyclase. we report here that pde2 encodes a high-affinity camp phosphodiesterase that shares sequence homology with animal cell phosphodiesterases. these results t ...	1986	3025832
human infection with ehrlichia canis, a leukocytic rickettsia.		1987	3029590
benign extraaxial tumors: contrast enhancement with gd-dtpa.	meningiomas, acoustic neuromas, and other benign extraaxial tumors have little contrast with adjacent brain tissue on conventional magnetic resonance (mr) images. the contrast enhancement produced by intravenous administration of 0.1 mmol/kg of gadolinium-dtpa in these tumors was measured on t1 mr images. acoustic neuromas showed the greatest enhancement (average, 310%), meningiomas the next greatest (average, 180%), and neurofibromas, glomus tumors, and pituitary microadenomas the least enhance ...	2010	3031727
benign extraaxial tumors: contrast enhancement with gd-dtpa.	meningiomas, acoustic neuromas, and other benign extraaxial tumors have little contrast with adjacent brain tissue on conventional magnetic resonance (mr) images. the contrast enhancement produced by intravenous administration of 0.1 mmol/kg of gadolinium-dtpa in these tumors was measured on t1 mr images. acoustic neuromas showed the greatest enhancement (average, 310%), meningiomas the next greatest (average, 180%), and neurofibromas, glomus tumors, and pituitary microadenomas the least enhance ...	2010	3031727
childhood infection caused by ehrlichia canis or a closely related organism.		1988	3050859
digitalis. an update of clinical pharmacokinetics, therapeutic monitoring techniques and treatment recommendations.	the intestinal absorption of digoxin is essentially a passive non-saturable diffusion process, although a saturable carrier-mediated component also plays an important role. the bioavailability varies between 40 and 100%: the presence of food may reduce the peak serum concentration, but does not reduce the amount of digoxin absorbed. recent development of a capsule containing a hydroalcoholic vehicle may reduce interindividual variations in absorption. pharmacokinetic analysis of the distribution ...	2008	3052985
inhibition of drug metabolism by quinolone antibiotics.	a number of quinolone antibiotics have been found to reduce the hepatic clearance of coadministered drugs such as theophylline. enoxacin appears to be the most potent inhibitor, consistently decreasing theophylline clearance by more than 50%, while a single study suggests a similar degree of inhibition with pipemidic acid. ciprofloxacin and pefloxacin reduce theophylline clearance to a smaller extent (approximately 20 to 30%). however, with ciprofloxacin, larger changes and theophylline toxicity ...	2005	3052987
[chronic bronchial obstruction and the pathogenesis of emphysema].		2008	3053141
[the respiratory tract and air pollution].		2008	3053144
c-heterochromatin variation and transposition in tumor progression.		2004	3066156
molecular implications of ph (+) myelodysplastic syndrome.	we report a case of 62-year-old japanese male with a myelodysplastic syndrome (mds) with a philadelphia (ph) chromosome. cytogenetic analysis revealed the bone marrow cells to contain a ph chromosome due to t(?;11;22) (?;q11;q11), as well as -5, -7, +8, -12 and an extra ph, in addition to cells with a normal karyotype. molecular analysis using breakpoint cluster region probes (5' bcr and 3' bcr) did not detect a rearrangement within the bcr dna sequences, indicating that the breakpoint at 22q11 ...	1988	3066168
estrogenic control of spermidine/spermine n1-acetyltransferase activity in rat uterus.		1988	3076330
fused maxillary second and third molars: report of a rare case with literature review.		2011	3078009
retropharyngeal hematoma: complication of cervical fracture.		2011	3083373
challenging conventional aminoglycoside dosing regimens. the value of experimental models.	although newer antimicrobials look promising for the treatment of serious gram-negative infections, aminoglycosides still remain part of the mainstay of their therapy. traditional intermittent therapy is based upon the premise that high serum aminoglycoside concentrations are toxic. however, the rate of bacterial killing for aminoglycosides is also a concentration-dependent phenomenon. two animal models of pseudomonas pneumonia were utilized to examine the efficacy of non-traditional aminoglycos ...	1986	3089001
[better integration of the student into the activities of the ward. goal-oriented integration during the first week is of decisive importance].		2011	3090364
[fluoride prevention--concerning the health risk].		2011	3090743
sonographic diagnosis of a chylous mesenteric cyst.		2010	3091647
daily urinary protein loss in schistosoma haematobium infection.	proteinuria was studied in 128 children aged 6 to 18 years with schistosoma haematobium infection in the people's republic of congo. urinary protein concentration in spontaneously voided midday urine of patients with greater than 100 ova/10 ml was significantly higher than in 24-hr urine specimens. median daily urinary protein loss in patients with moderate intensity of infection (100-350 ova/10 ml) was 300 mg and 584 mg/1.73 m2 body surface in heavily infected patients (greater than 350 ova/10 ...	1986	3094395
enzyme histochemistry of human melanomas and pigmented naevi with special reference to alpha-d-mannosidase activity.	a histochemical study of alpha-d-mannosidase revealed that normal human melanocytes (resting state, activated, lentigo simplex) exhibit either no or just detectable activity, as do melanocytes in the initial phase of lentigo maligna. junctional, or occasionally zone a naevocytes displayed a very low enzyme activity. on the other hand, melanocytes in the initial stage of neoplastic transformation (dysplastic naevi, advanced stage of lentigo maligna) and also melanoma cells in disorders of low mal ...	1986	3096914
chronic cardiac toxicity after inhalation of 1,1,1-trichloroethane.	two patients showed evidence of chronic cardiac toxicity after repeated exposure to 1,1,1-trichloroethane. in both cases there was circumstantial evidence of a deterioration after routine anaesthetic use of the related compound halothane. an adolescent boy who sniffed trichloroethane presented with multiple ventricular arrhythmias during tonsillectomy. follow up showed mild chronic left ventricular impairment. a 54 year old man had repeated industrial exposure to trichloroethane and deteriorated ...	1987	3105712
chronic cardiac toxicity after inhalation of 1,1,1-trichloroethane.	two patients showed evidence of chronic cardiac toxicity after repeated exposure to 1,1,1-trichloroethane. in both cases there was circumstantial evidence of a deterioration after routine anaesthetic use of the related compound halothane. an adolescent boy who sniffed trichloroethane presented with multiple ventricular arrhythmias during tonsillectomy. follow up showed mild chronic left ventricular impairment. a 54 year old man had repeated industrial exposure to trichloroethane and deteriorated ...	1987	3105712